TWAS hub - DDX4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0830	0.0250	1.6e-08	0.072	0.083	0.080	0.085	0.078	4.1e-09	2.4e-10	5.0e-10	1.7e-10	8.9e-10
2	ROSMAP	Brain Pre-frontal Cortex	0.0695	0.0241	8.0e-06	0.076	0.036	0.058	0.040	0.072	4.7e-10	1.6e-05	6.5e-08	6.3e-06	1.5e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Height	17.5	336.6	358.0	-17.8	-18.9
Standing height	15.8	156.4	165.6	-12.1	-12.9
Comparative height size at age 10	12.3	67.8	68.1	-8.2	-8.2
Sitting height	10.4	74.0	75.0	-8.6	-8.7
Waist Hip Ratio (WHR)	9.6	43.4	48.6	-7.0	-6.2
Trunk predicted mass	7.8	44.6	44.8	-6.7	-6.7
Trunk fat-free mass	7.5	42.8	43.0	-6.5	-6.6
Age at First Birth	6.0	8.7	9.1	-2.9	-3.0
Alzheimer’s Disease (including proxy)	5.8	8.5	10.2	-3.2	-2.6
Whole body fat-free mass	5.5	31.7	31.9	-5.6	-5.7
Arm predicted mass (right)	5.2	26.7	27.2	-5.2	-5.1
Forced expiratory volume in 1-second (FEV1), predicted	5.2	10.8	11.0	-3.3	-3.2
Arm fat percentage (right)	5.1	20.1	22.5	4.7	4.2
Arm fat-free mass (right)	5.0	25.4	25.6	-5.1	-5.0
Whole body water mass	5.0	28.8	28.9	-5.3	-5.4
Arm fat percentage (left)	4.9	19.5	21.9	4.7	4.1
Arm fat-free mass (left)	4.8	24.2	25.2	-5.0	-4.8
Heart disease (mother)	4.6	5.6	6.6	-2.6	-2.2
Arm predicted mass (left)	4.6	23.6	24.0	-4.9	-4.8
Alzheimer’s Disease (in mother)	4.1	4.8	6.0	-2.4	-1.9
Comparative body size at age 10	3.8	10.6	13.9	2.7	3.7
Hearing aid user	3.8	4.3	5.3	2.3	1.8
Basal metabolic rate	3.8	21.0	21.3	-4.5	-4.6
Body mass index (BMI)	3.6	15.3	15.9	4.0	3.8
Loneliness, isolation	3.6	4.9	6.6	2.6	1.8
Breastfed as a baby	3.5	4.4	4.6	-2.0	-2.1
Diabetes (father)	3.4	4.2	5.4	-1.8	-2.3
Age at first live birth	3.2	5.6	6.4	-2.5	-2.2
Mouth/teeth dental problems: Loose teeth	3.1	3.7	4.8	2.2	1.6
Heart attack	3.0	3.8	4.4	2.1	1.8
Diabetes diagnosed by doctor	3.0	4.9	5.9	-2.4	-2.0
Leg fat percentage (left)	3.0	10.9	12.0	3.5	3.1
Lung FVC	2.9	15.0	16.2	3.7	4.0
Medication: Levothyroxine sodium	2.9	4.8	5.1	2.1	2.3
Pulse wave Arterial Stiffness index	2.9	3.4	3.6	-1.8	-1.9
Body fat percentage	2.9	11.6	14.0	3.7	3.0
Medication: Lisinopril	2.9	3.8	4.9	1.6	2.2
Heart attack/myocardial infarction (self-reported)	2.9	3.8	4.4	2.1	1.8
Qualifications: None of the above	2.8	5.9	6.2	2.5	2.4
Leg fat percentage (right)	2.8	10.1	11.1	3.3	3.0
Alzheimer’s Disease (in father)	2.7	2.9	3.0	-1.7	-1.7
BMI	2.7	15.8	16.7	3.9	4.1
Commuting to job workplace: Public transport	2.7	3.2	3.6	-1.6	-1.9
Vitamin and mineral supplements	2.6	3.6	3.9	2.0	1.8
Leg fat-free mass (left)	2.6	13.8	14.3	-3.6	-3.8
Leg predicted mass (left)	2.5	13.3	13.7	-3.6	-3.7
Tinnitus: Yes, now most or all of the time	2.5	3.0	4.2	2.0	1.3
Basal cell carcinoma (self-reported)	2.5	3.0	3.7	-1.5	-1.9
Leg predicted mass (right)	2.4	12.9	13.1	-3.6	-3.6
Commuting to job workplace: Cycle	2.4	2.9	3.0	1.7	1.7
Hypothyroidism/myxoedema (self-reported)	2.3	4.6	4.8	2.1	2.2
Exposure to tobacco smoke outside home	2.3	3.0	3.9	2.0	1.5
Leg fat-free mass (right)	2.3	12.5	12.7	-3.5	-3.6
Hearing difficulty/problems: Yes	2.2	3.4	4.2	2.1	1.6
Forced vital capacity (FVC)	2.2	8.5	9.6	-3.1	-2.7
Friendships satisfaction	2.2	2.8	3.5	1.4	1.9
High cholesterol (Self-reported)	2.2	3.9	4.5	-1.8	-2.1
Hip circumference	2.1	8.9	11.0	3.3	2.6
Age at last live birth	2.1	3.1	3.4	-1.8	-1.7
Hypertension (Self-reported)	2.1	5.9	7.7	2.0	2.8
Qualifications: nursing, teaching	2.1	3.2	3.7	-1.9	-1.6
Blood White Count	2.0	14.6	14.7	-3.8	-3.8
Hypothyroidism (self reported)	2.0	4.5	5.5	2.4	1.9
High blood pressure	2.0	5.6	7.9	1.8	2.8
Had menopause	2.0	2.6	3.0	-1.5	-1.7
Medication: Blood pressure	2.0	3.5	3.9	2.0	1.7
Trunk fat percentage	1.9	7.8	10.0	3.2	2.4
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.4	6.4	-1.6	-2.5
Ever had prostate specific antigen (PSA) test	1.9	2.2	3.4	-1.0	-1.8
Respiratory disease	1.8	4.0	4.6	-2.1	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.8	5.2	1.5	2.3
Cholesterol lowering medication	1.8	2.6	2.9	-1.7	-1.5
Supplements: Zinc	1.7	1.9	2.2	-1.2	-1.5
Forced vital capacity (FVC), Best measure	1.7	6.4	7.6	-2.8	-2.3
Number of full sisters	1.7	2.0	2.2	1.4	1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	2.3	-1.5	-1.1
Blood Platelet Count	1.6	18.6	23.3	-4.8	-3.7
Father’s age at death	1.6	2.2	2.7	-1.3	-1.6
Length of working week for main job	1.6	1.7	1.9	1.3	1.4
Knee pain experienced in last month	1.6	2.4	3.3	1.8	1.2
Handedness (chirality/laterality): Left-handed	1.6	2.0	2.3	-1.3	-1.5
Eye problems/disorders: Cataract	1.6	1.9	2.0	1.4	1.3
Alcohol drinker status: Previous	1.6	1.8	2.9	0.9	1.7
Headache pain in last month	1.5	2.7	3.7	-1.9	-1.3
Ever depressed for a whole week	1.5	1.8	2.2	1.2	1.5
Mean Putamen Volume	1.4	1.6	1.6	-1.3	-1.3
Medication: Co-codamol	1.4	1.6	2.4	1.6	0.8
Hearing difficulty/problems with background noise	1.4	2.2	3.0	1.7	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	2.6	1.6	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.9	2.7	1.6	1.0
Medication: Paracetamol	1.4	2.1	2.3	1.4	1.5
Vascular/heart problems diagnosed by doctor	1.4	3.8	5.3	-1.5	-2.3
Depressed Affect (Nagel 2018)	1.3	2.7	2.9	1.6	1.7
Multivitamins +/- minerals	1.3	1.7	2.1	-1.4	-1.1
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	2.8	-1.7	-1.1
Falls in the last year	1.3	1.7	1.9	-1.2	-1.4
Illnesses of father: Heart disease	1.3	1.8	2.3	-1.5	-1.1
Heart disease (siblings)	1.3	1.5	3.0	-0.4	-1.7
Body Mass Index (BMI) (2010)	1.2	1.6	2.1	1.1	1.4
HbA1C	1.2	1.3	1.7	-1.0	-1.3
Diabetes (self-reported)	1.2	1.9	1.9	-1.4	-1.4
Qualifications: College or University degree	1.2	3.6	4.7	-2.2	-1.6
Medication: Ibuprofen	1.2	1.4	2.2	-1.5	-0.8
Average weekly red wine intake	1.2	1.8	2.6	-1.0	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	2.3	1.5	0.7
Medication: Blood pressure	1.2	2.2	3.8	0.8	2.0
Neuroticism (Nagel 2018)	1.1	2.7	3.0	1.5	1.7
Medication: Metformin	1.1	1.6	1.7	-1.3	-1.3
High blood pressure (mother)	1.1	1.5	2.2	0.9	1.5
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	1.5	1.2	1.2
Number of live births	1.1	1.5	1.9	1.4	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.1	-1.5	-0.8
Mineral and other dietary supplements	1.1	1.4	1.7	1.3	1.1
Alcohol drinker status: Never	1.1	1.3	1.5	1.2	1.0
Ulcerative Colitis	1.0	1.5	1.5	-1.2	-1.2
Blood Red Count	1.0	9.3	11.8	-3.4	-2.6
Number of treatments/medications taken	1.0	1.8	1.9	-1.4	-1.3
Frequency of depressed mood in last 2 weeks	1.0	1.4	1.7	1.3	1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	3.9	-0.7	-2.0
Prospective memory result	1.0	1.3	1.5	1.0	1.2
Fasting Glucose	0.9	1.1	1.3	1.0	1.1
Heel T-Score	0.9	7.5	11.2	-2.0	-3.3
Relative age of first facial hair	0.9	1.9	2.4	-1.2	-1.5
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.4	0.8	1.2
Alcohol usually taken with meals	0.9	1.4	1.9	-1.0	-1.4
Depression (self-reported)	0.9	1.1	1.5	0.9	1.2
Pulse wave peak to peak time	0.9	1.0	1.0	1.0	1.0
Financial situation satisfaction	0.9	1.1	1.5	0.8	1.2
Impedance of leg (right)	0.8	3.7	4.4	-1.7	-2.1
Fed-up feelings	0.8	1.4	1.5	1.1	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.1	-0.8	-1.1
Illnesses of father: None of the above (group 1)	0.8	1.0	1.3	1.1	0.9
Number of self-reported non-cancer illnesses	0.8	1.4	2.4	1.5	0.6
Wears glasses or contact lenses	0.8	0.9	1.1	-0.8	-1.0
Medication: Atorvastatin	0.8	1.0	1.1	-1.0	-1.0
Neuroticism	0.7	1.7	1.9	1.4	1.2
Medication: Atenolol	0.7	0.9	1.5	0.6	1.2
Mouth/teeth dental problems	0.7	1.0	1.1	-1.0	-1.0
Hair/balding pattern: Pattern 3	0.7	1.1	1.5	0.8	1.2
Arm fat mass (right)	0.7	2.9	3.7	1.9	1.4
Osteoarthritis (self-reported)	0.7	1.0	1.9	1.4	-0.1
Average weekly champagne plus white wine intake	0.7	0.9	1.2	0.8	1.1
Age started oral contraceptive pill	0.7	0.9	1.2	-1.1	-0.8
Hand grip strength (left)	0.6	1.7	1.9	-1.4	-1.2
Medication for hormone replacement therapy	0.6	0.7	1.2	-1.1	-0.3
Townsend deprivation index at recruitment	0.6	0.9	1.2	0.8	1.1
Serious illness, injury or assault to yourself	0.6	0.8	1.1	-0.6	-1.1
Impedance of leg (left)	0.6	2.7	3.3	-1.5	-1.8
Nervous feelings	0.6	1.1	1.5	-0.8	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.3	-1.1	-0.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.1	0.6	1.1
Financial difficulties in last 2 years	0.6	0.8	1.0	0.8	1.0
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	2.7	-1.7	-1.2
Happiness	0.6	0.8	1.4	0.4	1.2
Asthma	0.6	1.2	1.4	-1.2	-1.0
Pulse wave reflection index	0.6	0.8	1.5	-1.2	-0.3
Shortness of breath walking on level ground	0.6	0.7	1.0	0.7	1.0
Medication: Seretide 50 evohaler	0.6	0.7	0.8	-0.9	-0.7
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.1	1.0	0.7
Medication for cholesterol	0.6	1.0	1.9	1.4	0.0
Back pain experienced in last month	0.6	0.9	1.7	1.3	0.4
Breast cancer (self-reported)	0.6	0.7	1.2	-0.5	-1.1
Arm fat mass (left)	0.6	2.6	3.3	1.8	1.4
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.4	-0.2	-1.2
Verbal and Numeric Reasoning (VNR)	0.5	1.1	1.8	-1.4	-0.7
Breast Cancer	0.5	1.1	1.2	1.1	1.0
Smoking Status	0.5	1.1	2.0	1.4	0.5
Cardiovascular Disease	0.5	1.8	2.4	1.0	1.6
Sensitivity / hurt feelings	0.5	0.9	1.0	1.0	0.9
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.1	1.1	0.9
Stomach or abdominal pain in last month	0.5	0.6	0.9	-0.7	-0.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.0	1.0	0.5
Chronic bronchitis/emphysema (father)	0.5	0.6	1.0	1.0	0.5
Hair/balding pattern: Pattern 2	0.5	0.6	0.8	0.6	0.9
Pain all over the body in last month	0.5	0.5	0.8	0.9	0.5
Medication: Ramipril	0.5	0.6	0.7	-0.8	-0.8
Weight	0.5	2.6	3.2	-1.4	-1.8
Illnesses of mother	0.5	0.6	0.8	0.9	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	2.3	-1.5	-0.9
Medication: Paracetamol	0.5	0.9	1.0	1.0	0.9
Medication: Amlodipine	0.5	0.7	1.1	0.5	1.1
High blood pressure (siblings)	0.5	0.8	0.9	0.9	0.8
Alcohol intake frequency.	0.5	1.2	1.7	0.8	1.3
Suffer from ‘nerves’	0.5	0.8	1.2	0.7	1.1
Had major operations	0.5	0.6	0.7	-0.8	-0.7
Ever had bowel cancer screening	0.5	0.6	0.7	0.8	-0.7
Ever taken oral contraceptive pill	0.5	0.6	0.9	0.9	0.5
Medication: Bendroflumethiazide	0.5	0.7	0.7	0.9	0.9
Fractured/broken bones in last 5 years	0.5	0.6	1.1	0.3	1.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	0.7	-0.7	-0.8
Bipolar Disorder (2018)	0.4	0.7	0.9	-0.9	-0.7
Bipolar Disorder (2011)	0.4	0.4	0.4	0.6	0.7
Lupus	0.4	0.6	1.0	-1.0	-0.4
Hand grip strength (right)	0.4	1.1	1.4	-1.2	-0.9
Average weekly fortified wine intake	0.4	0.5	0.9	-0.9	-0.4
Relative age voice broke	0.4	0.6	0.9	-0.5	-0.9
Supplements: Glucosamine	0.4	0.6	1.0	-0.4	-1.0
Medication: Lansoprazole	0.4	0.4	0.6	0.8	0.5
Lung cancer (father)	0.4	0.4	0.7	0.9	0.4
Migraine (self-reported)	0.4	0.5	0.8	0.9	0.3
Asthma (self-reported)	0.4	0.8	1.0	-1.0	-0.8
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.9	-0.9	-0.4
Diastolic blood pressure, automated reading	0.4	1.4	2.7	0.1	1.7
Unable to work because of sickness or disability	0.4	0.5	0.9	0.9	0.4
Crohns Disease (2017)	0.3	0.7	1.5	-0.0	1.2
Coronary Artery Disease (CAD)	0.3	0.4	0.5	0.7	0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	0.7	-0.9	-0.7
Average weekly spirits intake	0.3	0.3	0.4	-0.5	-0.6
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.5	-0.7	-0.3
Pack years adult smoking proportion	0.3	0.5	0.8	0.9	0.5
Qualifications: CSEs or equivalent	0.3	0.5	0.6	0.5	0.8
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.6	-0.5	-0.8
Blood clot in the leg (DVT)	0.3	0.4	0.5	-0.6	-0.7
Glaucoma (self-reported)	0.3	0.4	0.6	-0.3	-0.8
Number of full brothers	0.3	0.4	0.5	-0.5	-0.7
Neck or shoulder pain in last month	0.3	0.4	0.5	-0.6	-0.7
Family relationship satisfaction	0.3	0.3	0.4	0.6	0.6
Long-standing illness, disability or infirmity	0.3	0.4	0.6	0.5	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.6	0.7	0.8
Medication: Aspirin	0.3	0.4	0.6	-0.8	-0.3
Smoking status: Current	0.3	0.4	0.9	0.9	-0.2
Miserableness	0.3	0.5	0.6	0.8	0.6
Pack years of smoking	0.3	0.5	0.8	0.9	0.4
Leg fat mass (left)	0.3	1.0	1.6	1.3	0.7
Depression (Nagel 2018)	0.2	0.3	0.4	0.6	0.5
Intelligence (Savage-Jansen 2018)	0.2	0.8	1.5	-1.2	-0.2
Worry (Nagel 2018)	0.2	0.5	0.6	0.6	0.8
Crohns Disease (2012)	0.2	0.2	0.3	-0.5	0.4
HDL Cholesterol	0.2	0.3	0.3	0.5	0.6
Primary Biliary Cirrhosis	0.2	0.3	0.4	-0.5	-0.7
Allergy or Eczema	0.2	0.5	0.7	0.6	0.8
Lung FEV1/FVC ratio	0.2	1.2	2.0	1.4	0.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.5	-0.0	-0.7
Severe depression (siblings)	0.2	0.3	0.3	-0.4	-0.6
Current tobacco smoking	0.2	0.3	0.3	0.5	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.3	-0.5	-0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.3	-0.3	0.6
Trunk fat mass	0.2	0.8	1.5	1.2	0.4
Past tobacco smoking	0.2	0.3	0.6	-0.8	-0.2
Neuroticism score	0.2	0.5	0.8	0.9	0.5
Mouth/teeth dental problems: Dentures	0.2	0.3	0.5	0.7	0.5
Exposure to tobacco smoke at home	0.2	0.3	0.5	0.7	-0.1
Birth weight of first child	0.2	0.3	0.6	-0.8	-0.3
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.4	-0.6	0.2
Worry too long after embarrassment	0.2	0.3	0.3	0.5	0.6
Number of children fathered	0.2	0.2	0.3	0.6	-0.3
Health satisfaction	0.2	0.3	0.4	-0.4	-0.6
Medication: Allopurinol	0.2	0.3	0.4	0.3	0.7
Medication: Omeprazole	0.2	0.2	0.4	0.1	-0.6
Mean time to correctly identify matches	0.2	0.5	0.8	-0.3	-0.9
Whole body fat mass	0.2	0.9	1.5	1.2	0.5
Leg fat mass (right)	0.2	0.9	1.4	1.2	0.6
Leg pain on walking	0.2	0.3	0.4	0.6	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.3	0.6	0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	0.1	0.6
Medication: Aspirin	0.2	0.3	0.5	-0.7	-0.2
Supplements: Vitamin C	0.2	0.2	0.3	-0.4	-0.5
Commuting to job workplace: Walk	0.2	0.3	0.5	0.7	0.2
Medication: Gliclazide	0.2	0.2	0.3	-0.4	-0.5
Guilty feelings	0.2	0.3	0.6	0.1	-0.8
Ever smoked	0.2	0.4	0.6	0.8	0.3
Average weekly beer plus cider intake	0.2	0.3	0.6	-0.8	-0.2
Pain experienced in last month	0.2	0.3	0.4	0.4	0.6
Impedance of whole body	0.2	1.1	1.8	-0.7	-1.3
Bipolar Disorder or Schizophrenia	0.1	0.1	0.1	-0.3	-0.4
Schizophrenia vs Biploar Disorder	0.1	0.1	0.1	0.3	0.3
Irritable Bowel Disease (IBD)	0.1	0.3	0.5	-0.2	0.7
Ulcerative Colitis (UC)	0.1	0.2	0.3	-0.6	-0.1
Reaction Time	0.1	0.2	0.4	-0.2	-0.6
Ovarian Cancer	0.1	0.2	0.3	-0.1	-0.6
Prostate Cancer	0.1	0.1	0.2	-0.4	-0.0
Neuroticism (2016)	0.1	0.1	0.3	0.1	0.5
Rheumatoid Arthritis	0.1	0.1	0.2	-0.4	0.2
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.1	0.4	0.4
Blood Eosinophil Count	0.1	0.5	0.6	0.8	-0.6
Chronotype (morning person)	0.1	0.1	0.2	0.2	-0.5
Hair Pigment	0.1	2.1	2.4	1.5	1.3
Tanning	0.1	0.7	1.3	1.1	0.2
Diabetes (mother)	0.1	0.1	0.1	0.0	0.4
Taking other prescription medications	0.1	0.1	0.1	0.4	-0.4
Age when periods started (menarche)	0.1	0.3	0.5	-0.7	-0.2
Number of incorrect matches in round	0.1	0.1	0.2	0.4	0.2
Illnesses of siblings	0.1	0.2	0.3	-0.1	0.6
Impedance of arm (right)	0.1	0.3	0.6	-0.0	-0.8
Worrier / anxious feelings	0.1	0.1	0.2	-0.3	-0.4
Pulse rate	0.1	0.2	0.4	-0.1	-0.6
Noisy workplace	0.1	0.1	0.3	0.5	0.0
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.6	-0.8	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.3	-0.4
Impedance of arm (left)	0.1	0.5	0.9	-0.1	-1.0
Tense / ‘highly strung’	0.1	0.1	0.3	0.1	-0.5
Loud music exposure frequency	0.1	0.1	0.1	-0.2	0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.1	-0.3	0.3
Birth weight	0.1	0.3	0.3	-0.5	-0.6
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.3	0.1	-0.6
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	-0.0	-0.5
Eye problems/disorders: None of the above	0.1	0.2	0.3	-0.5	-0.0
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.5	-0.1
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	-0.5	-0.5
Overall health rating	0.1	0.2	0.2	0.3	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	0.3	0.4
Illnesses of siblings: Diabetes	0.1	0.1	0.2	-0.1	-0.5
Osteoporosis (self-reported)	0.1	0.1	0.1	0.4	0.0
Mother’s age at death	0.1	0.1	0.1	-0.1	0.4
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.1	-0.5
Number of operations (self-reported)	0.1	0.2	0.2	-0.3	-0.4
Irritability	0.1	0.1	0.3	0.0	0.5
Risk taking	0.1	0.1	0.1	0.4	0.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.4	-0.2
Schizophrenia (2018)	0.0	0.0	0.1	0.3	0.1
Major Depression (MDD)	0.0	0.0	0.0	-0.2	-0.2
LDL Cholesterol	0.0	0.1	0.1	0.3	0.2
Schizophrenia (2014)	0.0	0.1	0.1	-0.2	-0.4
Triglycerides	0.0	0.1	0.1	-0.3	0.1
Systolic Blood Pressure	0.0	0.1	0.1	-0.1	0.3
Ever had hysterectomy (womb removed)	0.0	0.0	0.0	-0.1	-0.1
Systolic blood pressure, automated reading	0.0	0.1	0.2	-0.1	0.4
Angina	0.0	0.0	0.1	-0.2	-0.1
Maternal smoking around birth	0.0	0.0	0.0	-0.2	-0.1
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	0.2	-0.3
Waist circumference	0.0	0.1	0.2	0.4	0.2
Had other major operations	0.0	0.0	0.0	-0.2	-0.0
Allergy	0.0	0.0	0.0	0.0	-0.1
Medication: Simvastatin	0.0	0.0	0.0	-0.0	-0.0
Fluid intelligence score	0.0	0.0	0.0	-0.2	0.1
Time employed in main current job	0.0	0.0	0.0	0.2	0.1
Alcohol intake versus 10 years previously	0.0	0.0	0.0	0.1	-0.1
Medication: Cholesterol lowering	0.0	0.0	0.1	-0.1	-0.3
Hair/balding pattern: Pattern 4	0.0	0.1	0.1	0.3	-0.2
Peak expiratory flow (PEF)	0.0	0.0	0.0	0.1	0.2
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	-0.0	-0.1
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	-0.3	-0.1
Gout (self-reported)	0.0	0.0	0.0	0.2	0.2
Angina (self-reported)	0.0	0.0	0.0	-0.0	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.1	0.1	0.3	0.2
Pulse rate, automated reading	0.0	0.1	0.2	-0.5	-0.0
Chest pain or discomfort	0.0	0.0	0.0	-0.2	-0.0
Smoking status: Previous	0.0	0.1	0.1	-0.1	-0.3
Mood swings	0.0	0.0	0.0	-0.0	0.1
Illnesses of father: High blood pressure	0.0	0.0	0.0	0.1	-0.0
Myopia	0.0	0.0	0.0	-0.1	-0.1
Supplements: Calcium	0.0	0.0	0.1	-0.3	-0.1

Hub : Genes

DDX4

Models

Trait associations