TWAS hub - PPAP2A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.2210	0.0790	0.00140	0.188	NA	0.091	NA	0.149	9.4e-07	NA	6.8e-04	NA	1.4e-05
2	TCGA	Breast Invasive Carcinoma	0.0616	0.0314	0.00073	0.033	0.016	0.028	NA	0.029	2.2e-07	0.00020	1.7e-06	NA	1.1e-06
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.1350	0.0652	0.00690	0.004	0.027	0.026	NA	0.026	1.0e-01	0.00044	5.2e-04	NA	5.9e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Height	10.7	207.0	392.5	-11.9	-19.8	-9.3
Standing height	9.3	92.1	172.2	-8.3	-13.1	-6.0
Comparative height size at age 10	6.6	36.4	69.4	-4.6	-8.3	-4.3
Sitting height	6.5	45.9	83.9	-6.7	-9.2	-3.0
Waist Hip Ratio (WHR)	6.4	28.7	42.0	-2.7	-6.5	-6.1
Mouth/teeth dental problems: Loose teeth	6.2	7.3	10.3	2.3	3.2	2.5
Trunk fat-free mass	4.9	27.9	52.2	-5.0	-7.2	-2.6
Trunk predicted mass	4.9	28.2	53.3	-4.9	-7.3	-2.7
Hearing aid user	4.9	5.5	12.0	-0.6	2.0	3.5
Age at First Birth	4.5	6.6	10.7	-2.8	-3.3	-1.1
Alzheimer’s Disease (in mother)	4.0	4.7	10.4	0.1	-1.9	-3.2
Hair/balding pattern: Pattern 2	4.0	5.0	10.2	-1.8	1.3	3.2
Pulse wave Arterial Stiffness index	4.0	4.6	10.0	-0.7	-1.8	-3.2
Whole body fat-free mass	3.9	22.4	41.2	-4.8	-6.4	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	3.6	7.5	14.7	-2.4	-3.8	-1.5
Whole body water mass	3.6	20.8	38.1	-4.6	-6.2	-1.8
Diverticular disease/diverticulitis (self-reported)	3.5	4.1	9.4	3.1	1.6	0.7
Arm predicted mass (right)	3.3	16.8	32.8	-3.7	-5.7	-1.9
Heart disease (mother)	3.2	3.9	7.1	-1.2	-2.7	-1.8
Arm fat-free mass (right)	3.1	16.0	30.2	-4.0	-5.5	-1.4
Arm fat-free mass (left)	3.1	15.9	29.6	-4.0	-5.4	-1.6
Arm predicted mass (left)	3.1	15.8	29.6	-3.9	-5.4	-1.5
Basal metabolic rate	3.0	16.8	29.7	-4.4	-5.5	-1.3
Alzheimer’s Disease (including proxy)	2.9	4.2	8.6	0.4	-1.9	-2.9
HbA1C	2.7	3.0	4.7	-1.8	-2.2	-0.9
Loneliness, isolation	2.6	3.6	5.4	2.2	2.3	0.8
Leg fat-free mass (left)	2.5	13.2	21.8	-4.2	-4.7	-0.7
Forced vital capacity (FVC)	2.5	9.5	14.4	-3.8	-3.6	-0.8
Medication: Ibuprofen (e.g. Nurofen)	2.5	3.2	5.3	-0.9	-2.3	-1.9
Forced vital capacity (FVC), Best measure	2.5	9.0	14.4	-3.2	-3.8	-1.5
Comparative body size at age 10	2.5	6.9	14.0	0.5	2.5	3.7
Medication: Lisinopril	2.5	3.2	5.5	1.5	2.3	1.3
Medication: Co-codamol	2.4	2.8	3.4	1.8	1.8	1.3
Heel bone mineral density (BMD) T-score, automated (left)	2.4	5.5	7.2	-2.7	-1.8	2.5
Leg predicted mass (left)	2.4	12.9	21.7	-4.0	-4.7	-0.8
Pulse wave peak to peak time	2.4	2.8	7.6	0.3	0.9	2.8
Leg fat-free mass (right)	2.4	12.7	20.9	-4.1	-4.6	-0.5
Diabetes diagnosed by doctor	2.4	4.0	5.2	-2.3	-2.1	-1.6
Leg predicted mass (right)	2.4	13.0	21.5	-4.2	-4.6	-0.6
Medication: Ibuprofen	2.3	2.8	4.2	-0.4	-2.0	-2.1
Arm fat percentage (left)	2.3	9.3	16.6	1.3	4.1	3.1
Arm fat percentage (right)	2.2	8.6	16.6	1.2	4.1	2.8
Friendships satisfaction	2.2	2.8	4.9	0.4	2.2	1.8
Basal cell carcinoma (self-reported)	2.2	2.6	6.1	0.1	-1.3	-2.5
Vitamin and mineral supplements	2.0	2.7	3.5	1.2	1.8	1.9
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	4.1	2.0	1.6	0.5
Respiratory disease	1.9	4.3	7.5	-2.7	-2.3	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.4	5.5	-2.3	-1.6	2.2
Lung FVC	1.8	9.0	18.4	0.8	4.3	2.8
Townsend deprivation index at recruitment	1.8	2.5	5.7	1.3	2.4	-0.2
Pain type(s) experienced in last month: Hip pain	1.8	2.3	4.1	1.7	-0.1	-2.0
Commuting to job workplace: Cycle	1.8	2.2	4.4	0.5	2.1	1.4
Type 2 Diabetes (T2D) (2018)	1.7	3.1	6.5	-2.6	-1.5	-0.8
Number of treatments/medications taken	1.7	3.0	4.0	-2.0	-1.7	-1.4
Body mass index (BMI)	1.7	7.2	12.7	0.8	3.6	2.9
Father’s age at death	1.7	2.3	4.3	-1.4	-2.1	-0.8
Falls in the last year	1.7	2.3	4.5	-0.5	-1.4	-2.1
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	3.5	-1.9	-1.4	-0.6
Family relationship satisfaction	1.7	2.0	4.3	-2.1	-0.0	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	4.0	1.0	2.0	1.0
Commuting to job workplace: Public transport	1.7	2.0	3.2	-1.8	-1.7	-0.1
Mean Putamen Volume	1.6	1.8	3.2	-0.5	-1.4	-1.8
Heel T-Score	1.6	12.5	32.6	-1.9	-1.1	5.7
Medication: Metformin	1.6	2.2	3.0	-0.9	-1.7	-1.7
Financial difficulties in last 2 years	1.6	2.2	4.4	2.1	1.2	-0.8
Medication: Aspirin	1.6	2.2	3.9	0.2	-2.0	-1.6
Alcohol drinker status: Never	1.6	1.9	3.3	0.8	1.8	1.3
Alzheimer’s Disease (in father)	1.5	1.6	2.3	1.5	-0.8	-1.4
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	4.0	-2.0	-1.6	-0.5
Prospective memory result	1.5	1.8	3.4	1.4	1.9	-0.1
Medication: Aspirin	1.5	2.0	3.2	0.5	-1.8	-1.6
Illnesses of father: None of the above (group 1)	1.5	1.8	4.4	-0.1	2.1	1.0
Blood White Count	1.4	10.1	18.3	-2.0	-4.3	-2.8
Diabetes (mother)	1.4	1.8	4.5	0.0	0.9	2.1
Had other major operations	1.4	1.7	3.8	0.9	-0.8	-1.9
Body fat percentage	1.4	5.5	10.1	1.4	3.2	2.1
Qualifications: nursing, teaching	1.4	2.1	4.9	-2.2	-1.2	0.0
Mineral and other dietary supplements	1.4	1.9	3.5	0.7	1.3	1.9
Financial situation satisfaction	1.4	1.7	2.4	0.7	1.5	1.6
Average weekly spirits intake	1.3	1.6	2.1	-0.9	-1.5	-1.4
Average weekly fortified wine intake	1.3	1.5	2.0	-1.4	-1.4	-0.8
Exposure to tobacco smoke outside home	1.3	1.7	2.5	0.7	1.6	1.5
Osteoporosis (self-reported)	1.3	1.6	3.8	-0.0	-1.0	-2.0
Leg fat percentage (left)	1.3	4.8	9.4	1.7	3.1	1.5
Pack years adult smoking proportion	1.2	1.8	3.6	1.3	1.9	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.9	-2.0	-0.9	-0.1
Medication: Atenolol	1.2	1.5	3.0	0.9	0.8	-1.7
Number of incorrect matches in round	1.2	2.0	3.2	1.8	1.6	-0.2
Qualifications: O levels/GCSEs or equivalent	1.2	1.8	2.5	-1.5	-1.6	-1.0
Gout (self-reported)	1.2	1.7	2.6	-1.6	0.8	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	2.2	-1.5	1.1	0.9
Ever had bowel cancer screening	1.2	1.4	2.2	1.4	-0.2	-1.5
Guilty feelings	1.2	1.9	2.7	-1.3	-1.6	-1.2
Ovarian Cancer	1.1	1.5	3.1	1.1	-0.4	-1.8
Coronary Artery Disease (CAD)	1.1	1.3	2.1	0.3	1.4	1.4
BMI	1.1	6.4	11.4	0.6	3.4	2.7
Sensitivity / hurt feelings	1.1	1.9	5.1	2.2	0.6	-0.3
High blood pressure (mother)	1.1	1.6	2.4	1.1	1.5	1.1
Leg fat percentage (right)	1.1	4.1	8.1	1.7	2.9	1.2
Age at first live birth	1.1	2.0	5.7	-0.5	-2.4	-0.2
Migraine (self-reported)	1.1	1.4	2.8	-1.7	-0.6	1.1
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	2.4	0.5	1.5	1.2
Pack years of smoking	1.1	1.7	3.3	1.3	1.8	0.4
Blood Platelet Count	1.0	11.4	23.8	-2.3	-4.9	-2.3
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.2	1.2	1.5	-0.6
Medication for hormone replacement therapy	1.0	1.2	1.8	1.3	-0.2	-1.3
Trunk fat percentage	1.0	4.0	7.0	0.8	2.6	2.1
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.4	1.6	1.0	-0.1
Had menopause	1.0	1.3	2.4	0.4	-1.6	-1.1
Hip circumference	1.0	4.2	8.6	-1.3	1.5	2.9
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	5.3	-2.3	-2.3	-0.3
Hair/balding pattern: Pattern 4	1.0	2.4	4.6	2.1	-0.4	-1.5
Headache pain in last month	1.0	1.8	3.1	-1.0	-1.1	-1.8
Illnesses of siblings: Diabetes	1.0	1.2	2.5	-1.6	-0.5	0.9
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.7	0.5	-0.1	-2.2
Average weekly beer plus cider intake	1.0	1.4	3.2	-0.6	-1.8	-0.8
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.0	-1.4	-0.2	0.9
Diabetes (father)	0.9	1.2	1.7	0.4	-1.3	-1.3
Weight	0.9	4.3	8.0	-2.8	-2.2	0.3
Medication: Lansoprazole	0.9	1.0	2.2	1.0	1.5	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	5.0	-1.9	-2.2	-0.7
Glaucoma (self-reported)	0.9	1.0	1.7	-0.6	-1.0	-1.3
Neck or shoulder pain in last month	0.9	1.3	2.3	-1.2	-1.5	-0.1
Bipolar Disorder (2011)	0.8	0.8	1.6	-0.8	1.2	0.2
Neuroticism (2016)	0.8	1.1	3.0	-1.7	-0.6	-0.1
Hypothyroidism (self reported)	0.8	1.7	3.1	1.4	1.7	-0.5
Relative age of first facial hair	0.8	1.7	2.4	-1.0	-1.4	-1.5
Supplements: Zinc	0.8	0.9	1.7	-0.3	-1.0	-1.3
Qualifications: None of the above	0.8	1.6	3.5	1.1	1.9	0.4
Diabetes (self-reported)	0.8	1.2	1.7	-1.3	-1.1	-0.9
Medication: Simvastatin	0.8	1.2	1.9	0.9	-1.0	-1.4
Number of live births	0.8	1.1	1.3	1.0	1.1	1.1
Happiness	0.8	0.9	1.4	-0.9	0.8	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	2.4	0.7	1.6	1.0
Birth weight	0.8	1.8	4.2	-2.1	-0.2	1.1
Worry too long after embarrassment	0.8	1.4	2.0	-1.4	-0.3	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.2	-0.2	-0.7	-1.5
Qualifications: College or University degree	0.8	2.5	4.7	-1.7	-2.2	-0.1
Alcohol intake frequency.	0.8	1.9	2.9	1.6	1.7	0.3
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.5	1.6	0.3	-0.3
Average weekly red wine intake	0.8	1.2	2.8	-0.9	-1.7	0.1
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.6	-1.0	-1.3	0.3
Medication for cholesterol	0.8	1.2	2.7	-0.2	0.9	1.6
Age started oral contraceptive pill	0.8	1.0	1.7	0.5	-1.3	-1.1
Major Depression (MDD)	0.7	0.8	1.5	-1.2	-0.9	-0.4
Chronotype (morning person)	0.7	1.6	2.9	1.3	-0.6	-1.7
Hand grip strength (right)	0.7	1.8	2.8	-1.5	-1.7	0.6
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.6	-0.2	1.3	0.9
Qualifications: CSEs or equivalent	0.7	1.0	2.5	1.6	0.6	-0.3
Hair/balding pattern: Pattern 3	0.7	1.0	2.2	0.8	1.5	-0.5
Noisy workplace	0.7	0.9	1.4	1.2	1.1	-0.1
Lung cancer (father)	0.7	0.8	1.8	-1.3	-0.6	0.5
Length of working week for main job	0.7	0.7	1.4	1.2	0.8	-0.3
Medication: Paracetamol	0.7	1.2	3.5	0.2	0.2	-1.9
Shortness of breath walking on level ground	0.7	0.9	1.5	1.2	1.0	-0.4
Medication: Seretide 50 evohaler	0.7	0.8	1.0	-0.7	-1.0	-0.9
Suffer from ‘nerves’	0.7	1.1	2.0	1.4	0.6	-0.9
Knee pain experienced in last month	0.7	1.1	1.6	1.2	1.3	-0.4
Long-standing illness, disability or infirmity	0.7	1.1	1.4	1.1	0.7	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.3	-0.0	-1.1	-1.0
Smoking status: Current	0.7	1.0	1.5	-1.2	-1.0	-0.8
Medication: Blood pressure	0.7	1.4	2.6	1.6	1.0	-0.7
Medication: Bendroflumethiazide	0.7	1.0	2.7	0.7	0.1	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.3	1.1	1.2	0.2
Breast Cancer	0.6	1.4	1.9	1.4	1.4	0.8
Lupus	0.6	0.9	2.3	-1.5	-0.1	0.7
Triglycerides	0.6	0.9	1.9	-1.4	-0.4	-0.8
Impedance of leg (right)	0.6	2.9	6.5	1.0	-1.1	-2.5
Fed-up feelings	0.6	1.0	1.6	0.6	1.3	1.0
Alcohol usually taken with meals	0.6	1.0	1.6	0.9	-1.3	-0.7
Heart attack	0.6	0.8	0.9	0.9	0.9	0.9
Illnesses of siblings	0.6	0.8	1.3	1.0	0.3	-1.1
Worrier / anxious feelings	0.6	1.1	2.2	-0.8	-1.5	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.1	1.7	0.1	-1.2	-1.3
Birth weight of first child	0.6	1.2	2.8	-1.7	-0.4	0.8
Blood clot in the leg (DVT)	0.6	0.8	1.3	-1.0	-1.1	-0.0
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.3	-0.9	-0.3	-1.1
High blood pressure (siblings)	0.6	0.9	1.7	-0.9	0.2	1.3
Wheeze or whistling in the chest in last year	0.6	1.1	2.0	-1.4	-1.1	-0.2
Angina (self-reported)	0.6	0.8	1.7	0.6	1.3	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.3	-1.1	0.6	0.5
Chest pain or discomfort	0.6	0.9	2.6	-0.0	-0.4	-1.6
Supplements: Vitamin C	0.6	0.7	1.0	-0.7	-1.0	-0.9
Illnesses of father: Heart disease	0.6	0.9	1.6	-0.7	-1.3	-0.7
Ever taken oral contraceptive pill	0.6	0.7	1.1	-1.0	0.1	1.0
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.0	-1.0	-0.8	-0.8
Fractured/broken bones in last 5 years	0.6	0.8	1.3	1.1	0.2	-1.1
Cholesterol lowering medication	0.6	0.8	1.2	-0.5	-1.0	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.2	-1.0	-1.1	0.4
Depressed Affect (Nagel 2018)	0.5	1.0	2.0	0.6	1.4	0.9
Schizophrenia (2018)	0.5	1.0	2.5	-1.6	-0.7	-0.1
Primary Biliary Cirrhosis	0.5	0.7	1.6	-0.5	-1.3	-0.4
Schizophrenia (2014)	0.5	1.0	1.4	-1.2	-1.0	-0.8
Ulcerative Colitis	0.5	0.7	1.3	0.7	-0.5	-1.1
Hand grip strength (left)	0.5	1.4	2.6	-1.6	-1.1	0.6
Hearing difficulty/problems: Yes	0.5	0.7	1.6	0.2	1.3	0.7
Current tobacco smoking	0.5	0.8	1.2	-0.9	-1.1	-0.7
High blood pressure	0.5	1.3	3.0	0.9	1.7	0.3
Multivitamins +/- minerals	0.5	0.6	1.0	-1.0	-0.7	-0.5
Supplements: Glucosamine	0.5	0.6	1.3	0.2	-0.7	-1.2
Nervous feelings	0.5	0.9	1.1	1.0	-0.7	-1.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.1	1.1	0.4	-0.9
Peak expiratory flow (PEF)	0.5	1.1	2.8	-1.7	-0.3	0.7
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.8	1.0	1.3	-0.5
Medication: Blood pressure	0.5	0.8	1.6	0.9	1.3	0.3
Medication: Omeprazole	0.5	0.6	0.9	0.9	0.9	-0.4
Breast cancer (self-reported)	0.5	0.6	1.2	-0.8	0.1	1.1
Asthma (self-reported)	0.5	0.9	1.7	-1.3	-0.8	0.6
High cholesterol (Self-reported)	0.5	0.9	1.8	0.1	-1.4	-0.9
Medication: Paracetamol	0.5	0.8	1.9	0.4	0.4	-1.4
Illnesses of father: High blood pressure	0.5	0.7	1.6	1.3	0.0	-0.7
Fasting Glucose	0.4	0.4	0.8	0.7	0.9	0.3
Blood Red Count	0.4	3.6	9.2	-0.9	-3.0	-0.8
Lung FEV1/FVC ratio	0.4	1.8	4.2	2.0	0.8	-0.8
Angina	0.4	0.6	1.5	0.3	1.2	-0.3
Maternal smoking around birth	0.4	0.5	1.2	-0.2	-1.1	-0.6
Relative age voice broke	0.4	0.6	1.4	-0.6	-1.2	0.3
Age when periods started (menarche)	0.4	1.0	2.3	-1.5	-0.8	-0.1
Chronic bronchitis/emphysema (father)	0.4	0.5	1.0	0.2	-0.6	1.0
Impedance of leg (left)	0.4	2.1	4.6	1.1	-0.7	-2.1
Mouth/teeth dental problems: Dentures	0.4	0.6	1.3	-0.4	1.1	0.7
Depression (self-reported)	0.4	0.5	1.0	0.6	-0.1	-1.0
Tense / ‘highly strung’	0.4	0.7	1.8	1.3	-0.1	-0.4
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.8	0.9	0.2	-0.8
Number of full brothers	0.4	0.5	1.0	1.0	0.7	-0.2
Health satisfaction	0.4	0.6	1.4	-0.2	-0.5	-1.2
Medication for pain relief, constipation, heartburn	0.4	0.7	1.9	-0.5	0.1	1.4
Number of full sisters	0.4	0.5	0.6	0.6	0.7	0.8
Overall health rating	0.4	0.8	2.2	0.6	0.2	-1.5
Had major operations	0.4	0.5	0.9	-1.0	-0.7	-0.4
Hypertension (Self-reported)	0.4	1.2	3.0	0.8	1.7	0.3
Commuting to job workplace: Walk	0.4	0.5	1.2	0.2	1.1	0.4
Arm fat mass (left)	0.4	1.7	3.4	-0.6	1.1	1.9
Average weekly champagne plus white wine intake	0.4	0.5	1.4	0.2	1.2	0.3
Ever smoked	0.4	0.8	1.3	-0.8	0.6	1.1
Number of operations (self-reported)	0.4	0.6	1.3	-0.1	-0.7	-1.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.7	0.5	0.8	0.8
Depression (Nagel 2018)	0.3	0.4	1.1	-1.0	-0.2	-0.2
Prostate Cancer	0.3	0.5	0.6	-0.5	-0.8	0.7
Allergy or Eczema	0.3	0.7	2.1	-1.4	-0.4	-0.1
Taking other prescription medications	0.3	0.4	1.2	-1.1	-0.1	-0.2
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.6	-0.8	-0.5	0.2
Mouth/teeth dental problems	0.3	0.4	0.8	-0.4	-0.6	0.9
Alcohol intake versus 10 years previously	0.3	0.5	1.5	1.2	-0.2	-0.2
Pulse rate	0.3	0.6	1.3	-0.1	-0.7	-1.1
Asthma	0.3	0.6	1.0	-1.0	-0.9	0.1
Illnesses of mother	0.3	0.4	0.5	0.4	0.7	0.7
Arm fat mass (right)	0.3	1.4	2.7	-0.3	1.2	1.6
Exposure to tobacco smoke at home	0.3	0.3	0.7	-0.8	0.3	0.3
Pulse wave reflection index	0.3	0.4	0.9	-0.3	-0.4	-1.0
Medication: Amlodipine	0.3	0.4	1.0	0.2	-0.2	-1.0
Age at last live birth	0.3	0.4	1.0	0.3	-1.0	0.5
Back pain experienced in last month	0.3	0.4	0.7	0.9	0.6	0.1
Medication: Gliclazide	0.3	0.3	0.5	-0.7	-0.4	-0.5
Ever depressed for a whole week	0.3	0.3	0.6	0.6	0.8	0.1
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.2	-0.9	-1.1	0.1
Pain experienced in last month	0.3	0.5	1.3	-0.1	0.5	1.1
Heart disease (siblings)	0.3	0.4	0.8	0.1	0.7	0.9
Bipolar Disorder (2018)	0.2	0.3	0.6	0.8	0.6	0.3
Schizophrenia vs Biploar Disorder	0.2	0.3	0.5	-0.4	-0.3	-0.7
Irritable Bowel Disease (IBD)	0.2	0.5	1.3	0.4	0.2	-1.2
Ulcerative Colitis (UC)	0.2	0.3	0.5	0.6	-0.1	-0.7
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	-0.9	0.2	-0.1
Crohns Disease (2012)	0.2	0.3	0.8	-0.1	0.3	-0.9
LDL Cholesterol	0.2	0.3	0.5	-0.4	0.7	0.4
Rheumatoid Arthritis	0.2	0.3	0.6	-0.8	0.5	0.2
Systolic Blood Pressure	0.2	1.2	3.5	-1.9	-0.1	-0.4
Smoking Status	0.2	0.5	1.4	-1.2	0.2	0.2
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	-0.4	-0.7	0.1
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	0.7	0.3	-0.2
Systolic blood pressure, automated reading	0.2	0.5	0.6	0.7	0.8	-0.5
Severe depression (siblings)	0.2	0.2	0.3	-0.5	-0.5	-0.5
Stomach or abdominal pain in last month	0.2	0.2	0.5	-0.1	0.4	0.7
Trunk fat mass	0.2	0.8	1.6	-0.7	0.4	1.3
Hearing difficulty/problems with background noise	0.2	0.4	0.7	-0.3	0.8	0.5
Allergy	0.2	0.4	0.7	0.8	0.6	-0.3
Pain all over the body in last month	0.2	0.2	0.5	-0.1	0.7	-0.2
Medication: Ramipril	0.2	0.3	0.4	-0.7	-0.4	-0.5
Fluid intelligence score	0.2	0.4	1.0	-0.5	-0.1	1.0
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.9	-0.5	-0.3	1.0
Medication: Cholesterol lowering	0.2	0.3	0.6	0.8	-0.3	-0.5
Breastfed as a baby	0.2	0.3	0.7	0.8	-0.1	-0.4
Loud music exposure frequency	0.2	0.2	0.4	-0.5	-0.6	0.3
Eye problems/disorders: None of the above	0.2	0.2	0.5	0.0	0.3	0.7
Emphysema/chronic bronchitis	0.2	0.3	0.5	-0.4	-0.7	-0.3
Medication: Allopurinol	0.2	0.3	0.5	-0.7	0.3	0.5
Pulse rate, automated reading	0.2	0.6	1.2	-0.8	-1.1	-0.0
Mood swings	0.2	0.3	0.6	-0.8	0.2	0.6
Osteoarthritis (self-reported)	0.2	0.3	0.5	0.1	0.7	-0.6
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	0.2	0.7	0.3
Medication: Atorvastatin	0.2	0.3	0.6	0.8	0.1	0.5
Irritability	0.2	0.3	0.7	-0.9	0.2	0.1
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	0.1	-0.6	-0.4
Unable to work because of sickness or disability	0.2	0.3	0.9	0.1	0.9	0.0
Supplements: Calcium	0.2	0.2	0.3	-0.0	-0.5	-0.6
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	-0.7	-0.2	0.0
Neuroticism (Nagel 2018)	0.1	0.3	0.7	0.0	0.5	0.8
Crohns Disease (2017)	0.1	0.2	0.4	-0.2	0.4	-0.6
Reaction Time	0.1	0.1	0.3	0.0	0.1	0.6
HDL Cholesterol	0.1	0.1	0.4	-0.6	-0.2	-0.0
Neuroticism	0.1	0.1	0.3	0.2	0.6	-0.1
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	-0.2	0.5	-0.2
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	-0.4	0.3	0.1
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.0	0.5	0.3
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.3	-0.5	0.3	0.3
Medication: Levothyroxine sodium	0.1	0.1	0.2	0.2	0.5	0.0
Waist circumference	0.1	0.2	0.6	-0.8	-0.3	0.1
Past tobacco smoking	0.1	0.2	0.3	0.4	-0.5	-0.5
Neuroticism score	0.1	0.1	0.2	0.5	0.2	-0.4
Impedance of arm (right)	0.1	0.4	1.0	0.5	0.0	-1.0
Time employed in main current job	0.1	0.1	0.1	-0.1	0.4	-0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.3	-0.1	-0.6	0.4
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	-0.5	0.3	0.4
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	-0.3	-0.4	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.3	0.2	-0.5
Number of children fathered	0.1	0.1	0.2	0.4	0.2	-0.1
Whole body fat mass	0.1	0.4	0.8	-0.5	0.4	0.9
Leg pain on walking	0.1	0.1	0.2	0.4	0.4	0.1
Eye problems/disorders: Cataract	0.1	0.2	0.4	0.2	0.7	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	0.3	0.6	-0.2
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	-0.7	0.3	-0.2
Miserableness	0.1	0.2	0.2	0.4	0.5	-0.4
Wears glasses or contact lenses	0.1	0.1	0.2	-0.0	-0.4	0.3
Mother’s age at death	0.1	0.1	0.1	-0.3	-0.4	0.0
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	-0.4	-0.5	-0.0
Risk taking	0.1	0.1	0.3	-0.3	0.2	0.5
Myopia	0.1	0.2	0.4	0.4	-0.2	-0.6
Alcohol drinker status: Previous	0.1	0.1	0.1	-0.4	-0.1	0.4
Impedance of whole body	0.1	0.7	1.4	0.7	-0.4	-1.2
Leg fat mass (left)	0.1	0.4	0.6	-0.3	0.6	0.8
Intelligence (Savage-Jansen 2018)	0.0	0.0	0.0	0.1	0.0	0.2
Worry (Nagel 2018)	0.0	0.1	0.2	-0.1	-0.5	-0.1
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	0.3	0.0	0.5
Blood Eosinophil Count	0.0	0.4	0.5	-0.3	-0.7	-0.7
Cardiovascular Disease	0.0	0.1	0.3	-0.5	0.1	-0.2
Hair Pigment	0.0	0.9	1.3	-1.0	1.1	0.7
Tanning	0.0	0.3	0.5	-0.6	0.3	0.7
Impedance of arm (left)	0.0	0.1	0.1	0.2	-0.1	-0.3
Mean time to correctly identify matches	0.0	0.1	0.2	0.3	0.0	0.4
Leg fat mass (right)	0.0	0.2	0.3	-0.2	0.5	0.6
Smoking status: Previous	0.0	0.0	0.0	-0.1	0.2	0.2
Diastolic blood pressure, automated reading	0.0	0.0	0.1	-0.3	0.1	-0.1

Hub : Genes

PPAP2A

Models

Trait associations