Hub : Genes

SLC38A9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.111	0.051	0.00570	-0.001	NA	-0.003	NA	-0.003	3.9e-01	NA	6.4e-01	NA	0.71000
2	GTEx	Brain Cerebellum	0.261	0.099	0.00120	0.133	NA	0.090	NA	0.099	9.7e-05	NA	1.3e-03	NA	0.00074
3	GTEx	Testis	0.109	0.048	0.00620	-0.004	NA	-0.005	NA	-0.006	5.5e-01	NA	6.4e-01	NA	0.86000
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.044	0.034	0.00790	0.017	0.021	0.031	NA	0.020	3.4e-02	0.02200	6.6e-03	NA	0.02300
5	TCGA	Brain Lower Grade Glioma	0.186	0.073	0.00480	0.001	0.027	0.036	NA	0.005	2.7e-01	0.00047	5.7e-05	NA	0.08800
6	TCGA	Thyroid Carcinoma	0.032	0.018	0.00014	0.037	0.036	0.034	NA	0.035	1.4e-04	0.00020	2.5e-04	NA	0.00023

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.1	0.1	0.2	-0.4	-0.1	0.5	0.0	-0.4	0.2
Bipolar Disorder or Schizophrenia	0.2	0.4	0.8	-0.9	0.4	0.6	0.5	-0.8	0.1
Depressed Affect (Nagel 2018)	0.9	1.8	3.6	1.9	-1.5	0.5	-1.4	0.6	-1.6
Depression (Nagel 2018)	0.1	0.1	0.3	0.2	0.3	-0.6	0.5	0.3	0.1
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.6	-0.7	0.9	0.2	1.2	0.4	0.4
Neuroticism (Nagel 2018)	0.7	1.6	3.0	1.7	-1.6	0.3	-1.5	0.7	-1.2
Schizophrenia (2018)	0.2	0.4	0.6	-0.8	0.7	0.4	0.6	-0.8	-0.1
Schizophrenia vs Biploar Disorder	0.5	0.7	2.5	1.2	0.0	-0.1	0.1	1.6	0.1
Worry (Nagel 2018)	0.1	0.2	0.4	0.6	-0.6	0.1	-0.4	0.1	-0.2
Alzheimer’s Disease (in mother)	0.9	1.1	2.0	-0.5	1.2	1.0	1.3	-0.1	1.4
Alzheimer’s Disease (in father)	1.2	1.3	3.0	-0.4	1.4	-0.4	1.7	-0.6	1.4
Alzheimer’s Disease (including proxy)	1.8	2.6	5.0	-1.1	1.9	1.0	2.2	-0.7	2.0
Crohns Disease (2017)	0.5	1.0	2.3	-0.0	-1.0	1.0	-1.1	1.5	-0.8
Irritable Bowel Disease (IBD)	0.6	1.4	3.0	0.0	-1.4	1.5	-1.7	-0.2	-1.1
Ulcerative Colitis (UC)	0.6	1.2	2.1	-0.6	-1.0	1.3	-1.4	-1.4	-0.7
Major Depression (MDD)	0.2	0.2	0.8	-0.0	-0.4	0.9	-0.4	0.5	0.1
Reaction Time	0.6	1.2	2.8	-1.3	-0.9	-0.2	-1.3	-1.7	-0.4
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.1	-0.2	1.0	0.7	1.0	0.3	0.5
Breast Cancer	0.1	0.3	0.8	-0.3	-0.5	-0.6	-0.6	0.3	-0.9
Ovarian Cancer	0.4	0.6	2.2	0.9	-0.2	-0.2	-0.5	1.5	0.1
Prostate Cancer	1.0	1.4	5.9	-1.0	0.8	0.0	0.7	2.4	0.5
Age at First Birth	4.5	6.5	13.2	-1.2	2.9	0.7	2.3	3.2	3.6
Bipolar Disorder (2011)	1.5	1.4	2.9	-0.7	-1.2	1.7	-1.0	-1.2	-1.2
Body Mass Index (BMI) (2010)	1.0	1.4	3.1	-0.1	-1.4	1.8	-1.3	-0.2	-1.2
Coronary Artery Disease (CAD)	0.3	0.3	0.9	0.0	-0.6	0.1	-0.8	0.9	-0.5
Crohns Disease (2012)	0.4	0.6	2.4	0.3	-0.4	0.8	-0.5	1.5	-0.2
Mean Putamen Volume	0.8	0.9	2.8	-0.3	-0.6	1.2	-0.5	-1.7	0.6
Fasting Glucose	0.8	1.0	1.7	1.0	-1.3	-0.8	-0.9	0.5	-1.2
HbA1C	1.8	2.0	4.9	-0.0	2.2	1.0	1.2	1.1	1.9
HDL Cholesterol	0.1	0.1	0.3	-0.1	-0.5	-0.3	-0.5	-0.3	-0.3
LDL Cholesterol	0.1	0.2	0.5	0.3	-0.5	0.5	-0.4	-0.7	-0.2
Lupus	0.7	1.1	1.8	-1.2	1.3	0.0	1.0	1.3	0.9
Neuroticism (2016)	0.4	0.6	2.2	0.7	0.2	0.9	0.3	1.5	0.4
Primary Biliary Cirrhosis	0.5	0.7	1.6	0.3	1.2	-0.7	0.7	0.7	1.1
Rheumatoid Arthritis	0.1	0.2	0.7	-0.9	-0.0	-0.1	-0.5	-0.0	-0.5
Schizophrenia (2014)	0.3	0.6	1.1	0.9	1.0	0.8	1.0	-0.1	0.4
Triglycerides	0.3	0.6	0.8	0.2	0.7	0.9	0.7	0.9	0.8
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	0.1	0.2	-0.4	0.1	-0.5	0.2
Ulcerative Colitis	0.4	0.5	2.6	0.1	-0.1	-0.3	-0.7	-1.6	-0.1
Blood Eosinophil Count	0.4	2.8	14.5	0.3	0.9	-3.8	0.3	0.8	0.7
Blood Platelet Count	0.7	8.2	18.7	-2.9	3.1	-0.8	2.7	2.2	4.3
Blood Red Count	0.6	5.9	10.6	-3.2	2.7	0.1	3.0	0.4	2.8
Blood White Count	1.4	10.0	19.7	-2.2	4.1	-0.0	4.0	1.7	4.4
Heel T-Score	0.9	7.3	27.2	-1.1	2.5	-5.2	0.8	-1.6	2.5
BMI	1.3	7.4	15.8	1.2	-4.0	1.6	-3.3	0.4	-3.7
Height	11.3	218.4	432.5	-9.4	19.1	-6.9	17.7	8.2	20.8
Waist Hip Ratio (WHR)	5.3	23.8	48.0	-4.2	5.6	-1.3	6.4	1.9	6.9
Systolic Blood Pressure	0.1	0.4	1.7	0.4	-0.3	0.7	0.0	1.3	0.4
Smoking Status	0.2	0.6	2.3	0.8	-0.1	-0.5	-0.6	-1.5	-0.2
Allergy or Eczema	0.4	1.1	2.4	-0.9	-1.2	-1.2	-1.5	0.8	-0.3
Cardiovascular Disease	0.1	0.2	1.2	0.3	-0.1	0.3	0.1	1.1	0.0
Hypothyroidism (self reported)	1.5	3.4	5.4	1.7	-2.0	2.2	-1.8	-0.2	-2.3
Respiratory disease	1.1	2.3	9.7	-3.1	0.9	1.0	0.1	-0.1	1.6
Type 2 Diabetes (T2D) (2018)	0.6	1.1	1.9	-1.4	1.2	0.0	1.2	0.5	1.3
Lung FEV1/FVC ratio	0.3	1.7	4.4	2.0	-0.5	-2.1	-0.4	0.4	-1.1
Lung FVC	1.1	5.7	14.3	2.1	-2.8	-0.0	-2.6	-1.0	-3.8
Neuroticism	0.6	1.3	2.7	1.3	-1.1	1.6	-1.0	0.6	-1.0
Chronotype (morning person)	0.3	0.6	1.2	0.9	0.7	-1.1	0.5	0.6	0.6
Hair Pigment	0.1	1.5	3.8	1.9	-1.1	1.4	-0.9	0.3	-0.9
Tanning	0.0	0.2	0.5	0.4	0.0	0.0	-0.3	-0.7	-0.6
Hand grip strength (left)	1.0	2.7	4.9	-1.7	1.8	-1.8	2.2	-0.4	1.3
Number of treatments/medications taken	0.9	1.6	2.8	-1.2	1.3	-1.1	1.0	1.1	1.7
Average weekly spirits intake	0.5	0.7	2.2	-0.7	0.3	0.7	0.1	1.5	0.8
Sensitivity / hurt feelings	0.8	1.3	3.9	2.0	-1.0	-0.2	-1.0	1.3	-0.7
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.4	0.8	-0.5	1.2	-0.5	0.1	-0.8
Hearing difficulty/problems: Yes	1.4	2.1	5.6	1.9	-0.6	-0.9	-1.1	2.4	-1.1
Relative age of first facial hair	0.9	1.9	3.6	0.4	1.9	1.2	1.5	-1.2	1.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.4	-0.7	-0.5	-0.9	-0.4	-1.2	-0.3
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.9	-0.3	0.4	0.2	0.8	1.4	1.1
Ever had hysterectomy (womb removed)	1.0	1.1	4.3	-0.2	-0.2	2.1	-0.3	1.5	-0.2
Systolic blood pressure, automated reading	0.3	0.8	2.7	-0.2	-1.1	1.6	-0.2	-0.2	-0.8
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.4	-0.7	-0.8	0.1	-0.4	-1.5	-0.9
Angina	0.4	0.6	2.0	-0.8	-0.1	-1.4	0.4	-0.6	-0.6
Medication for hormone replacement therapy	2.2	2.5	9.1	0.7	1.1	-0.9	1.4	3.0	1.2
Vitamin and mineral supplements	1.7	2.3	4.5	1.0	-1.7	0.4	-1.6	-1.6	-2.1
Supplements: Zinc	0.8	0.9	2.1	-1.1	1.5	0.0	0.9	0.4	1.0
Medication: Co-codamol	1.5	1.7	2.9	1.3	-1.5	0.4	-1.6	-0.6	-1.7
Medication: Metformin	1.0	1.4	2.4	-1.4	1.6	-0.3	1.4	-0.4	1.4
Diabetes (father)	0.7	0.9	2.7	-0.3	1.2	0.0	1.0	-0.3	1.6
Diabetes (mother)	0.6	0.8	2.3	-1.5	-0.1	-1.3	0.6	-0.5	-0.5
Severe depression (siblings)	0.8	0.9	1.9	-1.4	0.6	1.1	0.6	-1.2	-0.0
Pack years adult smoking proportion	0.8	1.2	2.2	1.0	-0.6	1.5	-0.8	-1.4	-1.2
Impedance of leg (right)	0.3	1.4	2.5	-1.0	1.1	-1.3	0.8	-1.1	1.6
Leg fat-free mass (left)	2.2	11.7	21.3	-2.3	4.3	-0.6	4.3	2.5	4.6
Trunk fat percentage	1.4	5.5	10.7	1.0	-3.3	1.5	-3.0	-1.4	-2.8
Hand grip strength (right)	1.2	3.4	6.3	-0.5	2.5	-1.3	2.5	1.7	1.7
Townsend deprivation index at recruitment	0.6	0.9	1.7	0.9	-1.2	0.0	-1.1	-0.3	-1.3
Current tobacco smoking	0.4	0.6	1.3	1.0	0.2	1.2	-0.2	-1.0	0.5
Average weekly fortified wine intake	1.0	1.2	4.1	-2.0	0.8	-0.6	0.8	0.2	1.2
Maternal smoking around birth	0.7	1.0	3.2	-0.4	0.6	-0.8	0.9	1.8	0.9
Fed-up feelings	1.2	2.1	3.3	1.8	-1.4	1.4	-1.4	1.3	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	-0.8	-0.1	-0.5	0.1	0.2	0.7
Relative age voice broke	1.0	1.6	3.6	0.7	1.9	-0.8	1.5	0.5	1.4
Taking other prescription medications	0.2	0.3	0.7	-0.8	0.0	-0.8	-0.2	-0.4	0.2
Age when periods started (menarche)	0.2	0.4	1.2	0.2	-0.3	1.1	-0.5	-0.6	0.5
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	5.5	-0.1	-0.2	2.3	0.0	1.3	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	4.9	-0.5	1.9	-1.6	0.5	1.2	2.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	1.3	1.1	0.1	-0.1	-0.3	-0.1	-0.4
Qualifications: CSEs or equivalent	0.4	0.6	2.6	1.6	0.5	-0.3	0.6	-0.0	-0.5
Serious illness, injury or assault to yourself	0.2	0.3	0.7	0.5	0.5	-0.2	0.6	-0.8	0.3
High blood pressure	0.7	1.8	3.1	1.4	-1.8	-0.5	-1.6	0.4	-1.6
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.7	0.0	-1.4	-1.2	-1.6	-0.3	-0.7
Multivitamins +/- minerals	0.4	0.5	1.1	-0.1	0.8	0.7	0.9	0.0	1.1
Stomach or abdominal pain in last month	0.3	0.4	1.1	-1.1	0.0	-0.8	0.3	-0.8	0.2
Supplements: Glucosamine	0.8	1.0	3.3	0.3	0.4	-1.8	0.6	1.2	0.7
Diverticular disease/diverticulitis (self-reported)	3.9	4.6	9.1	1.2	-2.1	3.0	-2.4	-1.9	-1.8
Medication: Atenolol	0.4	0.5	1.5	0.9	0.5	0.1	0.6	1.2	-0.5
Medication: Levothyroxine sodium	1.1	1.9	2.4	1.0	-1.6	1.1	-1.5	1.5	-1.5
Sitting height	5.6	39.7	85.2	-3.9	8.3	-1.1	7.6	3.1	9.2
Chronic bronchitis/emphysema (father)	0.3	0.4	1.5	1.2	-0.3	-0.7	-0.4	0.4	0.1
High blood pressure (mother)	0.4	0.6	1.9	0.5	-0.2	-1.4	0.3	0.8	-0.9
Body mass index (BMI)	1.7	7.2	14.9	1.1	-3.9	1.4	-3.2	-0.3	-3.8
Impedance of leg (left)	0.2	1.0	2.2	-0.7	1.0	-0.8	0.6	-1.5	1.2
Leg predicted mass (left)	2.2	11.4	20.9	-2.2	4.2	-0.7	4.3	2.5	4.6
Trunk fat mass	0.2	0.8	1.7	0.0	-1.3	1.1	-1.1	-0.4	-0.7
Waist circumference	0.0	0.1	0.3	-0.5	-0.5	0.4	-0.0	0.2	0.1
Number of incorrect matches in round	0.2	0.4	1.0	-0.3	-0.7	0.2	-0.3	-0.8	-1.0
Past tobacco smoking	0.4	0.8	2.7	-1.2	0.3	1.6	0.5	0.4	0.2
Alcohol usually taken with meals	0.2	0.3	0.7	-0.9	0.5	0.4	0.2	-0.3	0.6
Nervous feelings	0.4	0.8	1.9	0.1	1.1	0.9	1.4	-0.4	1.0
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	4.9	-1.4	2.1	-0.2	2.2	0.4	1.5
Hearing difficulty/problems with background noise	1.1	1.7	3.4	1.7	-1.2	-0.8	-1.8	0.8	-1.1
Hair/balding pattern: Pattern 2	1.7	2.2	3.8	-1.7	-1.4	1.0	-1.5	-1.9	-1.1
Had menopause	0.3	0.4	1.0	-0.6	-0.2	0.6	0.0	-0.6	1.0
Had other major operations	0.1	0.1	0.4	-0.4	-0.2	0.7	0.2	0.1	0.2
Forced vital capacity (FVC)	2.5	9.5	16.8	-1.5	4.0	-1.9	4.0	1.5	4.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	4.6	-0.8	1.1	-2.1	-0.3	1.1	1.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.8	-0.9	-0.6	-0.7	-0.1	0.1	-0.4
Qualifications: None of the above	1.2	2.5	5.3	1.1	-1.9	-0.5	-2.3	0.0	-2.1
Financial difficulties in last 2 years	0.6	0.8	1.7	1.3	-0.5	-1.0	-0.5	-0.5	-1.1
Mouth/teeth dental problems	0.4	0.7	3.0	-0.7	0.3	1.7	0.0	-0.6	0.4
Heart attack	1.6	2.1	3.7	1.6	-1.5	0.9	-1.9	0.4	-1.7
Allergy	0.3	0.7	1.8	0.7	0.6	1.3	1.1	0.3	-0.3
Pain all over the body in last month	0.9	1.0	5.1	0.1	-0.4	-2.3	-0.4	-0.3	-0.6
Diabetes (self-reported)	1.2	1.9	3.6	-1.2	1.9	-0.5	1.9	0.3	1.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.5	1.2	-0.6	-0.6	-0.9	-0.1	-0.4
Medication: Ramipril	0.3	0.3	1.1	-0.3	0.4	-0.1	0.5	-1.0	0.7
Medication: Simvastatin	0.7	1.0	1.3	-1.0	1.1	-0.7	1.1	1.1	0.9
Fluid intelligence score	0.2	0.5	2.1	0.6	0.1	1.4	-0.2	0.4	0.2
Illnesses of siblings	0.3	0.4	1.3	1.1	0.2	0.4	0.7	-0.7	-0.5
Neuroticism score	0.4	0.9	2.1	1.4	-0.8	0.7	-0.9	0.8	-0.6
Weight	0.5	2.2	4.6	-1.5	1.5	0.1	1.6	1.3	2.1
Impedance of arm (right)	0.2	0.9	4.4	0.2	-0.5	-0.4	-0.8	-2.1	-0.2
Arm fat percentage (right)	2.9	11.6	23.8	1.5	-4.9	1.6	-4.4	-1.1	-4.5
Trunk fat-free mass	5.2	29.7	55.3	-3.9	6.8	-1.5	6.8	3.6	7.4
Hip circumference	0.9	3.7	6.8	1.2	-2.6	1.2	-2.6	-0.4	-2.5
Time employed in main current job	1.1	1.3	2.7	-0.4	-1.2	-1.4	-0.8	-1.6	-0.8
Alcohol intake versus 10 years previously	0.3	0.5	1.7	0.8	0.3	-1.3	0.4	0.3	0.2
Father’s age at death	1.5	2.1	4.3	-2.1	1.6	-0.3	1.4	0.9	1.7
Worrier / anxious feelings	0.2	0.3	0.8	0.1	0.4	0.4	0.2	0.9	0.9
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	4.3	-1.2	1.9	-0.6	2.1	1.4	1.6
Falls in the last year	0.6	0.8	1.5	-0.7	1.2	-0.0	1.1	-0.3	1.2
Hair/balding pattern: Pattern 3	0.5	0.7	1.3	0.3	-1.0	-0.4	-0.8	1.1	-1.0
Number of live births	0.7	1.0	2.8	0.7	-0.9	0.0	-1.1	-0.5	-1.7
Forced expiratory volume in 1-second (FEV1)	1.7	5.6	8.6	-0.6	2.9	-2.5	2.9	1.9	2.5
Pulse rate	0.2	0.3	0.8	0.6	0.1	-0.6	0.2	0.9	0.2
Happiness	0.1	0.2	0.8	-0.1	-0.4	-0.2	-0.1	0.1	-0.9
Noisy workplace	0.8	1.0	2.9	1.7	-0.9	0.3	-1.0	-0.6	-1.0
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.2	-0.3	0.1	0.2	0.4	0.3	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	0.5	0.0	-0.6	0.2	-0.1	0.7
Mouth/teeth dental problems: Dentures	0.2	0.3	1.7	-0.0	-0.4	-0.1	-0.1	1.3	-0.3
Asthma	0.4	0.8	2.7	-1.6	0.3	-0.1	-0.2	-1.1	0.8
Medication: Ibuprofen (e.g. Nurofen)	3.2	4.0	14.2	-0.2	1.6	0.6	1.8	3.8	1.9
Medication: Cholesterol lowering	0.8	1.2	2.4	-0.7	1.6	-1.2	1.1	1.0	0.9
Depression (self-reported)	1.0	1.2	5.2	-0.6	-0.4	-2.3	0.1	-1.0	-0.3
Medication: Lansoprazole	2.3	2.6	5.8	2.1	-0.9	2.4	-1.5	0.6	-1.4
Prospective memory result	1.2	1.5	2.5	0.8	-1.1	-1.6	-0.8	-1.3	-1.4
Lung cancer (father)	0.4	0.4	1.8	0.4	0.2	0.5	-0.4	1.3	0.4
Illnesses of mother	0.9	1.1	1.5	1.2	-0.6	1.2	-1.0	-1.2	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.4	7.4	-0.4	2.7	-1.8	2.7	1.7	2.3
Pulse wave Arterial Stiffness index	1.2	1.4	2.8	-1.2	1.2	-0.7	1.7	-0.3	1.5
Impedance of arm (left)	0.2	0.7	3.6	0.3	-0.3	0.3	-0.7	-1.9	-0.1
Arm fat mass (right)	0.3	1.2	2.8	0.3	-1.7	0.7	-1.3	0.3	-1.4
Trunk predicted mass	5.3	30.4	56.9	-3.9	6.9	-1.5	6.8	3.6	7.5
Standing height	8.7	86.1	182.7	-6.2	12.2	-3.0	11.1	4.0	13.5
Length of working week for main job	1.2	1.4	3.1	0.7	-1.8	0.3	-1.5	-0.5	-1.5
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.2	0.3	0.2	0.5	-0.2	-0.1
Breastfed as a baby	2.1	2.7	6.2	-0.4	2.5	-0.5	2.2	1.4	1.6
Tense / ‘highly strung’	0.1	0.2	1.2	1.1	0.2	0.3	-0.3	-0.0	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.7	8.2	0.8	-2.0	1.3	-2.1	-2.9	-1.8
Hair/balding pattern: Pattern 4	0.2	0.4	1.5	1.2	-0.0	0.6	0.2	0.6	-0.1
Birth weight of first child	1.0	1.7	6.4	-2.5	0.4	-1.8	0.5	-0.3	0.5
Peak expiratory flow (PEF)	0.4	0.9	2.0	0.4	1.2	1.1	1.4	0.8	0.2
Pulse wave reflection index	0.3	0.4	1.2	-0.4	0.3	0.2	0.3	1.1	0.7
Ever highly irritable/argumentative for 2 days	0.5	0.5	1.7	0.5	-0.5	1.0	-0.2	-1.3	-0.4
Loud music exposure frequency	0.7	0.8	3.1	0.2	-0.0	1.8	0.1	1.2	0.2
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.3	1.0	1.0	0.8	1.2	1.0	1.1
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.1	-0.5	-0.1	-1.4	0.5	0.1	0.4
Blood clot in the leg (DVT)	1.0	1.3	2.4	-0.4	0.8	-1.5	0.6	1.4	1.6
Medication: Paracetamol	0.5	0.7	2.3	-0.1	-1.5	-0.5	-1.1	0.1	-0.8
Headache pain in last month	1.4	2.4	5.4	-2.3	1.1	-1.9	1.6	0.1	1.2
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.1	0.6	-0.7	1.1	-0.2	-0.8	-0.5
Glaucoma (self-reported)	1.5	1.8	6.6	-0.3	1.2	-2.6	1.0	-0.0	1.2
Gout (self-reported)	0.0	0.1	0.2	-0.4	-0.1	0.0	-0.3	-0.0	0.3
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	3.9	0.9	-2.0	1.7	-1.5	0.4	-2.0
Medication: Amlodipine	0.5	0.6	1.7	0.4	0.5	-1.3	0.2	1.3	0.1
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.2	-1.5	0.3	1.0	0.5	-0.6	0.1
Birth weight	0.1	0.2	0.5	0.6	0.7	0.3	0.6	-0.1	0.3
Chronic bronchitis/emphysema (mother)	0.8	1.0	3.2	-1.8	-0.2	-0.6	0.1	-1.4	0.3
High blood pressure (siblings)	0.7	0.9	2.2	-0.8	-0.9	-0.3	-1.5	1.3	-0.6
Forced vital capacity (FVC), Best measure	2.1	7.8	14.5	-1.1	3.6	-1.5	3.5	1.8	3.8
Body fat percentage	1.9	7.4	15.2	1.1	-3.9	1.4	-3.6	-1.3	-3.5
Leg fat percentage (right)	1.7	6.2	14.3	0.7	-3.8	1.2	-3.2	-0.6	-3.2
Arm fat-free mass (right)	3.7	18.8	34.9	-2.8	5.6	-0.7	5.5	2.8	5.9
Exposure to tobacco smoke outside home	2.3	3.0	6.0	1.6	-2.2	0.8	-2.4	-0.7	-1.8
Comparative body size at age 10	2.2	6.2	15.2	0.8	-3.9	-0.1	-3.4	0.7	-3.1
Number of full brothers	0.7	0.9	1.8	1.1	1.0	-1.3	0.5	0.8	0.5
Worry too long after embarrassment	0.4	0.6	2.2	0.9	-0.4	0.3	-0.7	1.5	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.2	0.9	-1.4	0.2	-1.5	-1.4	-1.1
Wheeze or whistling in the chest in last year	0.7	1.2	3.0	-1.7	-0.8	-0.3	-1.0	-1.6	-0.1
Number of children fathered	0.3	0.4	1.1	0.9	0.3	-1.1	0.4	-0.2	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	2.6	-0.8	1.6	0.5	1.4	-0.2	1.2
Age at first live birth	2.6	4.5	7.4	-1.5	2.7	-2.5	2.3	-0.1	2.5
Pulse wave peak to peak time	0.4	0.5	0.9	0.9	-0.4	0.5	-1.0	0.8	-0.6
Health satisfaction	0.1	0.2	0.4	0.5	0.2	0.7	0.5	-0.1	0.1
Shortness of breath walking on level ground	0.7	0.8	2.6	-0.1	-1.2	0.0	-0.9	-0.3	-1.6
Qualifications: College or University degree	0.8	2.6	7.8	-2.8	1.2	-0.9	1.4	-1.2	1.4
Eye problems/disorders: None of the above	0.4	0.5	1.0	-0.9	0.2	1.0	0.3	-0.9	-0.1
Mouth/teeth dental problems: Loose teeth	1.6	1.9	4.3	2.1	-1.3	-0.4	-1.2	-0.3	-2.0
Emphysema/chronic bronchitis	0.9	1.0	5.0	0.5	-0.3	2.2	-0.3	0.8	0.4
Medication for pain relief, constipation, heartburn	0.1	0.2	0.8	0.0	0.5	0.9	-0.0	-0.4	0.2
Neck or shoulder pain in last month	0.2	0.3	0.9	-0.9	0.3	0.3	0.2	0.1	0.9
Medication: Blood pressure	0.9	1.7	3.0	1.3	-1.3	-1.1	-1.7	0.4	-1.5
Angina (self-reported)	0.5	0.6	2.4	-0.4	-0.2	-1.6	0.2	-0.6	-0.8
Migraine (self-reported)	0.3	0.3	0.8	-0.2	-0.6	0.4	-0.9	-0.7	-0.4
Medication: Ibuprofen	2.9	3.5	13.0	0.4	1.5	0.2	1.4	3.6	1.9
Medication: Allopurinol	0.1	0.1	0.5	0.1	-0.4	-0.1	-0.3	-0.7	-0.1
Medication: Omeprazole	0.9	1.0	3.1	1.0	-0.3	-1.4	-0.1	-1.8	-0.1
Medication: Seretide 50 evohaler	0.3	0.3	0.6	-0.3	0.6	0.8	0.2	0.5	0.6
Mean time to correctly identify matches	0.7	1.3	2.4	-1.6	-1.1	0.3	-1.5	-1.2	-0.4
Heart disease (mother)	4.1	5.0	8.5	-2.0	1.9	-1.5	1.8	2.9	2.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.0	-1.4	0.1	0.0	0.3	-1.3	-0.5
Whole body fat mass	0.1	0.5	1.3	-0.3	-1.1	0.8	-0.9	-0.1	-0.7
Leg fat mass (right)	0.1	0.5	1.2	-0.2	-1.1	1.0	-0.7	0.4	-0.7
Arm predicted mass (right)	3.8	19.6	35.8	-2.9	5.7	-0.8	5.7	2.8	6.0
Pulse rate, automated reading	0.2	0.6	1.7	-0.8	-0.7	0.7	-0.2	1.3	0.2
Alcohol intake frequency.	0.6	1.4	3.1	1.0	-1.0	1.8	-0.6	-0.7	-1.5
Comparative height size at age 10	7.5	41.1	75.2	-5.2	8.3	-3.1	7.6	2.9	8.7
Number of full sisters	0.8	0.9	1.8	1.3	-1.0	-0.3	-1.0	-0.4	-1.3
Suffer from ‘nerves’	0.3	0.5	1.2	0.8	-1.1	-0.1	-0.6	0.6	-0.8
Overall health rating	0.6	1.2	4.6	1.3	-0.8	2.2	-0.6	-0.3	-0.2
Chest pain or discomfort	0.3	0.5	1.1	-1.1	0.5	-0.4	1.0	-0.1	0.4
Had major operations	0.5	0.6	1.6	-1.3	0.7	0.1	0.5	-0.8	0.7
Age at last live birth	1.9	2.8	5.2	-1.8	1.6	-2.3	1.3	-1.6	1.3
Family relationship satisfaction	1.1	1.3	2.2	1.5	-1.2	1.4	-1.2	0.9	-0.5
Leg pain on walking	0.1	0.1	0.4	0.2	-0.2	0.2	-0.2	0.6	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.5	0.3	-0.2	-0.6	0.3	-1.2	-0.7
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.2	1.1	0.1	-1.1	0.2	-0.1	0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.4	0.4	-0.4	-0.1	-0.4	0.6	-0.7
Medication: Aspirin	1.1	1.4	2.8	-0.1	1.5	-0.9	1.7	0.7	1.4
Supplements: Vitamin C	0.7	0.9	3.4	-1.0	0.1	0.3	0.2	1.9	0.7
Knee pain experienced in last month	0.9	1.4	2.5	1.6	-1.2	-0.3	-1.4	1.3	-0.8
Hypertension (Self-reported)	0.7	2.0	3.0	1.6	-1.7	-0.5	-1.7	0.3	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	2.5	0.6	-0.3	-0.5	-0.2	1.6	-0.1
Illnesses of father: Heart disease	0.7	1.0	2.8	0.7	1.0	0.5	0.6	1.1	1.7
Illnesses of siblings: Diabetes	0.7	0.9	2.3	-1.0	0.2	1.5	0.2	-1.3	0.5
Smoking status: Previous	0.9	1.4	7.5	0.3	0.4	-2.7	0.3	0.2	0.4
Forced expiratory volume in 1-second (FEV1), predicted	4.9	10.1	18.7	-1.1	4.1	-2.0	3.9	2.2	4.3
Whole body fat-free mass	4.1	23.5	42.9	-3.4	6.1	-1.2	6.1	3.2	6.5
Leg fat-free mass (right)	2.1	11.2	20.0	-2.1	4.3	-0.5	4.3	2.5	4.5
Arm fat percentage (left)	2.9	11.8	23.3	1.6	-4.8	2.0	-4.3	-1.2	-4.5
Average weekly red wine intake	1.7	2.5	4.0	-0.9	2.0	-1.8	1.6	1.1	1.8
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.5	-0.9	1.9	-1.5	1.6	0.2	1.3
Mood swings	0.0	0.0	0.1	0.2	-0.2	0.1	-0.3	0.2	-0.0
Loneliness, isolation	4.3	6.0	9.8	2.1	-3.1	0.8	-3.1	-1.9	-2.8
Long-standing illness, disability or infirmity	0.2	0.2	0.8	0.0	-0.3	0.6	-0.4	-0.9	-0.3
Ever had bowel cancer screening	0.4	0.5	0.8	0.8	-0.6	0.7	-0.8	-0.9	-0.2
Diabetes diagnosed by doctor	2.2	3.6	5.6	-2.1	2.4	-0.7	2.3	-0.1	2.4
Ever had stillbirth, spontaneous miscarriage or termination	5.3	5.7	8.9	-0.8	2.9	-3.0	2.8	1.8	2.2
Friendships satisfaction	1.1	1.4	3.6	0.2	-1.5	0.4	-1.4	0.5	-1.9
Qualifications: nursing, teaching	1.4	2.2	4.9	-2.2	1.5	0.1	1.9	0.2	1.6
Commuting to job workplace: Walk	0.5	0.6	1.3	-0.1	-0.9	0.6	-1.1	-0.2	-1.0
Eye problems/disorders: Cataract	1.3	1.5	2.7	1.6	-1.4	-0.4	-1.4	1.0	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.5	0.8	0.0	-1.2	-0.2	1.1	-0.2
Medication for cholesterol	2.4	3.6	7.1	0.4	-1.8	1.7	-2.3	-2.7	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.4	4.0	2.0	-1.5	-0.9	-1.8	1.6	-1.4
Back pain experienced in last month	0.4	0.6	2.2	1.5	-0.1	-0.9	-0.3	-0.1	-0.5
Mineral and other dietary supplements	1.2	1.6	1.9	1.4	-1.4	1.0	-1.4	-1.1	-1.4
Breast cancer (self-reported)	1.6	1.9	5.3	-1.6	-0.9	1.3	-1.1	-2.3	-0.2
Asthma (self-reported)	0.4	0.7	2.9	-1.7	0.2	-0.0	-0.3	-1.0	0.6
Osteoporosis (self-reported)	0.1	0.2	0.4	0.3	-0.4	-0.7	-0.3	-0.3	-0.0
Osteoarthritis (self-reported)	0.2	0.3	0.9	1.0	-0.5	0.7	-0.3	-0.1	-0.1
Medication: Aspirin	1.1	1.4	3.2	0.1	1.6	-0.7	1.8	0.5	1.4
Medication: Gliclazide	0.2	0.2	0.7	0.0	-0.2	0.8	-0.7	-0.1	0.1
Illnesses of father: None of the above (group 1)	1.4	1.7	3.6	-0.6	-1.4	1.0	-1.0	-1.5	-1.9
Smoking status: Current	0.5	0.8	2.1	1.1	-0.2	1.5	-0.6	-1.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	3.0	1.0	-0.6	-0.5	-0.5	1.7	-1.1
Whole body water mass	3.8	21.9	39.8	-3.1	5.9	-1.1	5.9	3.2	6.3
Leg predicted mass (right)	2.2	11.6	20.8	-2.0	4.4	-0.5	4.3	2.5	4.6
Arm fat mass (left)	0.3	1.2	2.9	0.0	-1.7	0.9	-1.3	0.3	-1.3
Number of self-reported non-cancer illnesses	0.5	0.9	2.4	1.0	-1.0	0.2	-1.5	-0.3	-0.9
Average weekly champagne plus white wine intake	0.7	1.0	4.2	0.4	-0.8	-2.1	-0.8	0.4	-0.7
Miserableness	0.2	0.4	0.7	0.8	-0.2	-0.8	-0.1	-0.7	-0.8
Guilty feelings	0.3	0.4	1.8	0.5	-0.0	1.4	-0.2	0.3	0.4
Wears glasses or contact lenses	0.7	0.8	2.7	-0.7	-0.8	0.3	-1.0	-1.6	0.1
Ever taken oral contraceptive pill	0.4	0.5	1.6	0.7	0.5	-1.3	0.1	-0.4	-0.5
Hearing aid user	1.8	2.0	3.6	0.0	-1.4	1.1	-1.9	1.5	-1.7
Mother’s age at death	0.2	0.2	0.9	-1.0	-0.5	-0.2	-0.2	0.3	-0.3
Financial situation satisfaction	1.1	1.3	2.5	1.0	-1.4	-0.3	-0.9	-1.2	-1.6
Tinnitus: Yes, now most or all of the time	1.9	2.2	4.0	1.6	-2.0	0.9	-1.9	-0.1	-1.6
Commuting to job workplace: Public transport	1.0	1.2	2.7	-0.9	0.9	1.3	0.3	1.2	1.7
Eye problems/disorders: Glaucoma	2.0	2.4	10.6	-0.8	1.0	-3.3	0.8	0.7	1.0
Medication: Blood pressure	0.6	1.2	3.3	1.8	-0.7	-0.2	-0.6	1.5	-0.7
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.6	0.4	0.8	0.7	0.7	-0.1	0.5
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.7	-0.5	1.3	-0.5	1.1	1.6	1.3
High cholesterol (Self-reported)	2.3	4.0	6.7	-2.1	2.4	-0.9	2.6	0.7	2.5
Medication: Bendroflumethiazide	0.1	0.2	0.5	0.7	0.1	0.5	0.1	0.7	-0.4
Medication: Paracetamol	0.9	1.3	3.5	0.4	-1.9	-0.1	-1.5	-0.4	-1.3
Medication: Lisinopril	1.6	2.1	6.1	0.8	-1.3	-0.2	-1.1	2.5	-1.6
Medication: Atorvastatin	0.3	0.4	0.7	-0.8	0.7	-0.6	0.5	0.0	0.8
Illnesses of father: High blood pressure	0.9	1.2	4.5	2.1	0.8	-1.1	0.4	0.7	0.3
Alcohol drinker status: Never	0.8	0.9	2.1	0.1	-0.9	0.7	-1.2	-0.9	-1.5
Ever smoked	0.5	0.9	1.9	1.3	-0.8	0.1	-0.9	-1.4	-0.6
Basal metabolic rate	3.0	16.7	30.5	-3.0	5.1	-1.1	5.1	2.9	5.5
Leg fat percentage (left)	1.9	6.7	14.4	0.8	-3.8	1.5	-3.3	-0.9	-3.4
Arm fat-free mass (left)	3.8	19.2	33.8	-3.3	5.4	-1.2	5.5	3.2	5.8
Number of operations (self-reported)	0.2	0.3	0.9	-0.7	-0.4	0.9	-0.3	-0.3	0.2
Average weekly beer plus cider intake	1.8	2.6	8.6	0.4	1.4	-0.2	1.4	2.9	1.7
Irritability	0.0	0.1	0.2	0.2	-0.3	-0.1	-0.3	-0.2	-0.4
Risk taking	0.2	0.3	1.2	0.2	-0.3	-1.1	-0.2	-0.7	-0.1
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.5	-0.0	0.1	0.4	-0.0	-0.5	0.7
Fractured/broken bones in last 5 years	0.9	1.1	2.5	1.3	1.0	0.4	1.3	1.6	0.2
Age started oral contraceptive pill	0.4	0.5	1.0	-1.0	0.4	0.0	0.9	-0.3	0.9
Diastolic blood pressure, automated reading	0.4	1.2	3.2	0.0	-1.8	1.2	-0.8	1.3	-0.7
Ever depressed for a whole week	0.8	1.0	2.8	0.4	-1.1	0.4	-0.7	-1.7	-1.0
Unable to work because of sickness or disability	0.8	1.1	3.4	1.4	-0.6	-1.8	-0.6	-0.2	-0.6
Commuting to job workplace: Cycle	1.1	1.3	3.5	0.4	-1.5	-0.5	-1.3	0.3	-1.9
Myopia	0.2	0.3	1.2	-1.1	0.2	-0.3	0.3	-0.6	0.3
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.0	-1.2	1.4	0.5	1.3	-0.8	1.2
Cholesterol lowering medication	2.5	3.7	6.0	-2.5	1.9	-1.6	2.3	0.7	2.0
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.1	1.2	-1.2	-0.5	-0.9	-1.5	-0.7
Pain experienced in last month	1.0	1.7	4.6	0.8	-1.3	2.1	-1.2	-0.5	-1.1
Supplements: Calcium	0.2	0.2	0.8	-0.9	-0.1	-0.5	-0.0	-0.2	-0.1
Basal cell carcinoma (self-reported)	1.0	1.2	2.7	-1.4	0.9	-0.5	0.4	1.0	1.6
Heart attack/myocardial infarction (self-reported)	1.5	2.0	3.4	1.5	-1.5	1.1	-1.8	0.4	-1.6
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.6	-0.5	0.8	-1.5	0.6	1.1	1.6
Heart disease (siblings)	0.4	0.5	1.2	-1.1	0.9	-0.4	0.4	0.5	0.7
Alcohol drinker status: Previous	0.9	1.1	4.6	0.1	0.1	-1.3	0.2	2.1	-0.2
Pack years of smoking	0.8	1.2	2.2	0.7	-0.6	1.5	-0.9	-1.4	-1.2
Impedance of whole body	0.1	0.7	3.3	0.1	0.3	-0.5	-0.2	-1.8	0.5
Leg fat mass (left)	0.2	0.7	1.4	-0.1	-1.2	1.1	-0.8	0.1	-0.8
Arm predicted mass (left)	3.7	19.0	33.2	-3.4	5.3	-1.6	5.3	3.2	5.8