Best TWAS P=9.56e-09 · Best GWAS P=1.03e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | C11orf1 | 0.06 | 0.06 | lasso | 5 | 0.05 | 4.4e-07 | -5.2 | 5.3 | 1.2e-07 | -0.97 | 0.07 | 0.92 | FALSE |
| 2 | GTEx | Esophagus Mucosa | SIK2 | 0.13 | 0.03 | lasso | 4 | 0.02 | 2.2e-02 | -5.7 | -5.4 | 6.3e-08 | 0.65 | 0.04 | 0.88 | FALSE |
| 3 | GTEx | Muscle Skeletal | C11orf1 | 0.04 | 0.05 | lasso | 4 | 0.02 | 3.5e-03 | -5.6 | 5.6 | 1.6e-08 | -1.00 | 0.03 | 0.94 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | CRYAB | 0.12 | 0.10 | lasso | 5 | 0.07 | 7.7e-05 | -5.6 | -5.7 | 1.6e-08 | 1.00 | 0.04 | 0.96 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | CRYAB | 0.07 | 0.04 | lasso | 10 | 0.02 | 1.3e-02 | -5.2 | -5.3 | 1.1e-07 | 0.98 | 0.05 | 0.89 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | C11orf1 | 0.06 | 0.05 | lasso | 2 | 0.02 | 9.6e-03 | -5.2 | 5.2 | 1.5e-07 | -0.97 | 0.06 | 0.88 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | C11orf1 | 0.04 | 0.02 | lasso | 2 | 0.03 | 2.1e-04 | -5.6 | 5.6 | 2.5e-08 | -1.00 | 0.02 | 0.98 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CRYAB | 0.03 | 0.02 | lasso | 1 | 0.01 | 2.2e-03 | -5.6 | -5.6 | 1.7e-08 | 1.00 | 0.00 | 0.96 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SIK2 | 0.04 | 0.01 | blup | 35 | 0.01 | 6.7e-03 | -5.0 | -5.2 | 2.5e-07 | 0.68 | 0.03 | 0.86 | FALSE |
| 10 | The Cancer Genome Atlas | Colon Adenocarcinoma | C11orf1 | 0.11 | 0.07 | enet | 2 | 0.08 | 3.4e-05 | -5.6 | 5.4 | 5.3e-08 | -0.99 | 0.00 | 0.97 | FALSE |
| 11 | The Cancer Genome Atlas | Colon Adenocarcinoma | FDXACB1 | 0.08 | 0.07 | lasso | 3 | 0.05 | 5.6e-04 | -5.6 | 5.7 | 9.6e-09 | -0.99 | 0.00 | 0.97 | TRUE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C11orf1 | 0.07 | 0.06 | enet | 3 | 0.08 | 7.0e-09 | -5.6 | 5.5 | 3.7e-08 | -0.93 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FDXACB1 | 0.13 | 0.05 | lasso | 1 | 0.05 | 2.4e-06 | -5.6 | 5.6 | 1.7e-08 | -1.00 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Adenocarcinoma | HSPB2 | 0.03 | 0.01 | blup | 5 | 0.03 | 2.3e-04 | -5.6 | -5.1 | 2.7e-07 | 0.85 | 0.00 | 0.93 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FDXACB1 | 0.03 | 0.02 | lasso | 1 | 0.02 | 5.9e-03 | -5.6 | 5.6 | 1.7e-08 | -1.00 | 0.00 | 0.88 | FALSE |