Hub : Genes

CRYAB

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Atrial Appendage	0.1280	0.0600	7.5e-03	-0.002	NA	-0.006	NA	-0.006	4.3e-01	NA	9.5e-01	NA	7.3e-01
2	GTEx	Skin Not Sun Exposed Suprapubic	0.1200	0.0470	5.3e-04	0.104	NA	0.059	NA	0.073	2.6e-06	NA	3.7e-04	NA	7.7e-05
3	GTEx	Skin Sun Exposed Lower leg	0.0700	0.0310	1.3e-03	0.042	NA	0.005	NA	0.017	2.2e-04	NA	1.2e-01	NA	1.3e-02
4	METSIM	Adipose	0.0342	0.0145	8.7e-05	0.031	0.029	0.025	0.027	0.024	1.5e-05	3.2e-05	1.1e-04	4.7e-05	1.5e-04
5	ROSMAP	Brain Pre-frontal Cortex	0.0331	0.0164	7.7e-03	0.001	0.009	0.001	0.006	0.002	2.0e-01	2.3e-02	2.1e-01	5.5e-02	1.4e-01
6	YFS	Blood	0.0166	0.0106	1.3e-02	0.002	0.006	0.014	0.008	0.007	8.2e-02	4.4e-03	1.3e-05	9.5e-04	1.9e-03
7	TCGA	Breast Invasive Carcinoma	0.0269	0.0168	1.7e-03	0.015	0.011	0.009	NA	0.011	3.5e-04	2.2e-03	5.2e-03	NA	2.2e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	2.4	3.8	8.3	2.1	1.8	1.7	-2.0	-2.9	-0.6	1.8
Bipolar Disorder or Schizophrenia	1.1	2.7	7.6	1.7	1.6	1.7	-0.4	-2.8	-0.8	1.6
Depressed Affect (Nagel 2018)	0.3	0.7	1.8	-1.0	-0.4	-0.6	1.3	1.0	-0.5	-0.4
Depression (Nagel 2018)	0.7	1.1	1.9	-1.1	1.0	1.1	1.0	-0.1	-1.4	1.0
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.0	-0.4	-1.3	-1.3	0.3	0.8	-0.1	-1.4
Neuroticism (Nagel 2018)	0.3	0.6	2.3	-0.9	-0.1	-0.0	1.5	1.0	-0.2	0.1
Schizophrenia (2018)	0.3	0.6	1.4	0.5	0.6	0.7	1.0	-1.2	-0.4	0.6
Schizophrenia vs Biploar Disorder	1.1	1.4	3.0	-0.8	-1.2	-1.2	1.7	1.4	-0.1	-1.2
Worry (Nagel 2018)	0.2	0.5	1.6	-0.8	-0.3	-0.5	1.2	0.8	-0.2	-0.3
Alzheimer’s Disease (in mother)	1.4	1.6	4.9	2.0	-0.1	-0.3	-2.2	-1.6	0.3	-0.1
Alzheimer’s Disease (in father)	0.5	0.5	1.2	0.5	-0.7	-0.5	-0.3	-0.9	1.1	-0.7
Alzheimer’s Disease (including proxy)	1.6	2.3	7.1	1.8	-0.5	-1.0	-2.7	-2.0	0.3	-0.5
Crohns Disease (2017)	0.7	1.5	3.4	-1.9	-1.1	-1.3	1.1	1.2	-0.4	-1.2
Irritable Bowel Disease (IBD)	0.5	1.2	3.4	-0.6	1.3	1.1	1.9	0.3	-0.5	1.2
Ulcerative Colitis (UC)	2.2	4.1	8.8	0.5	3.0	2.9	1.6	-0.4	-0.6	2.8
Major Depression (MDD)	0.3	0.3	1.4	-0.0	0.2	0.3	1.2	-0.0	-0.9	0.2
Reaction Time	2.6	4.9	7.9	2.0	2.8	2.4	-0.7	-2.4	-1.7	2.8
Verbal and Numeric Reasoning (VNR)	0.1	0.2	1.2	-1.1	-0.2	-0.0	-0.1	0.4	0.3	-0.2
Breast Cancer	2.3	5.6	9.9	0.1	2.7	3.1	2.4	0.6	-3.0	2.7
Ovarian Cancer	1.0	1.3	3.5	-1.9	1.3	1.1	1.1	0.1	-0.4	1.3
Prostate Cancer	1.2	1.7	4.0	-0.5	1.5	1.8	0.1	-0.0	-2.0	1.5
Age at First Birth	1.2	1.8	6.2	1.1	0.3	0.3	-2.1	-2.5	-0.9	0.3
Bipolar Disorder (2011)	1.2	1.2	4.5	0.4	1.9	0.0	0.0	-2.1	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.6	2.6	-0.4	-0.7	-0.4	-0.2	-0.4	-1.6	-1.0
Coronary Artery Disease (CAD)	2.3	2.7	5.1	0.8	2.0	1.8	-1.5	-1.4	-1.3	2.3
Crohns Disease (2012)	0.3	0.5	1.0	-1.0	-0.7	-1.0	0.1	-0.4	-0.6	-0.7
Mean Putamen Volume	0.5	0.5	1.1	0.3	-1.1	-0.8	0.4	0.7	0.4	-1.0
Fasting Glucose	0.3	0.4	1.0	0.2	-0.8	-1.0	0.1	0.9	-0.2	-0.3
HbA1C	0.7	0.8	4.1	0.2	0.4	0.6	0.1	-0.7	-2.0	0.8
HDL Cholesterol	2.5	4.1	14.5	-2.5	0.0	-0.0	3.8	2.7	0.9	-0.2
LDL Cholesterol	0.1	0.2	0.8	0.4	-0.4	0.1	-0.5	-0.0	-0.9	-0.4
Lupus	1.8	2.8	5.5	0.1	2.1	1.9	0.1	-1.3	-2.3	2.1
Neuroticism (2016)	1.1	1.6	4.3	-2.1	-1.1	-1.2	1.3	0.8	0.5	-1.2
Primary Biliary Cirrhosis	3.5	5.0	8.2	1.4	2.8	2.5	-1.4	-2.8	-0.9	2.9
Rheumatoid Arthritis	0.3	0.4	1.4	1.1	0.1	-0.4	-0.1	-0.7	1.2	0.1
Schizophrenia (2014)	0.3	0.7	2.7	0.9	0.1	0.3	0.3	-1.6	-0.9	0.1
Triglycerides	0.6	1.0	2.6	0.5	-1.0	-1.1	-1.2	0.5	0.3	-1.6
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.1	0.7	0.7	0.8	-0.3	-1.4	-1.5	1.2
Ulcerative Colitis	0.7	1.0	2.2	0.2	1.3	1.5	0.4	-1.2	0.5	1.2
Blood Eosinophil Count	1.4	10.9	22.8	1.9	3.6	3.6	-0.6	-3.3	-4.8	3.6
Blood Platelet Count	0.7	8.2	14.8	0.9	-3.3	-3.9	2.6	1.9	3.1	-3.3
Blood Red Count	0.7	7.2	20.2	1.0	-1.9	-1.2	-4.5	-3.4	3.1	-1.8
Blood White Count	0.3	2.1	5.3	2.3	-0.9	-0.8	-0.8	-2.1	1.4	-0.8
Heel T-Score	1.1	8.8	32.1	0.7	0.1	-0.1	-1.4	5.2	-5.7	0.0
BMI	0.2	1.3	5.0	0.8	-0.7	-0.5	-1.1	-0.9	-2.2	-0.6
Height	0.6	12.2	25.1	-2.6	-5.0	-4.4	-2.2	2.0	0.9	-5.0
Waist Hip Ratio (WHR)	9.7	43.7	139.2	8.6	1.2	1.3	-11.8	-9.3	1.2	1.3
Systolic Blood Pressure	4.1	20.7	49.3	1.6	6.6	7.0	-0.1	-2.7	-0.1	6.5
Smoking Status	0.7	1.6	5.5	-1.5	0.7	0.9	2.4	1.4	0.0	0.7
Allergy or Eczema	5.6	14.6	25.6	-1.4	-5.0	-5.1	1.7	3.6	3.1	-4.9
Cardiovascular Disease	5.5	18.2	40.2	1.5	5.8	6.3	-1.3	-3.6	-1.8	5.8
Hypothyroidism (self reported)	1.3	3.1	10.0	-0.5	1.4	1.5	2.2	-0.6	-3.2	1.4
Respiratory disease	4.3	9.5	18.4	-1.7	-4.2	-4.1	1.7	2.7	-0.0	-4.3
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.8	-0.5	1.0	1.3	0.9	0.1	-1.3	1.0
Lung FEV1/FVC ratio	0.2	0.8	1.5	0.4	-1.0	-0.7	0.5	1.1	-1.2	-0.9
Lung FVC	0.5	2.6	6.0	0.2	2.4	2.5	-0.1	-0.3	0.9	2.4
Neuroticism	0.5	1.2	4.1	-0.4	1.0	0.9	2.0	0.6	-1.1	0.9
Chronotype (morning person)	0.0	0.1	0.5	0.7	0.3	0.1	0.1	-0.1	-0.1	0.3
Hair Pigment	0.2	6.3	13.3	0.6	3.4	3.6	2.2	-0.2	-1.9	3.3
Tanning	0.1	1.3	3.6	1.0	0.0	-0.7	-1.9	-1.2	-1.5	0.1
Hand grip strength (left)	0.6	1.5	3.0	0.2	-1.5	-1.7	-1.3	-0.9	-0.7	-1.6
Number of treatments/medications taken	0.5	1.0	2.9	-0.7	1.1	1.7	-0.1	-0.6	-0.8	1.1
Average weekly spirits intake	0.4	0.5	2.5	-0.0	0.3	0.3	0.7	0.4	-1.6	0.2
Sensitivity / hurt feelings	2.3	4.0	7.7	-1.3	-2.7	-2.7	1.6	1.4	-0.3	-2.8
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.8	-0.9	1.0	1.1	0.9	-0.1	-1.4	1.0
Hearing difficulty/problems: Yes	0.2	0.3	0.5	0.5	-0.5	-0.7	0.3	0.2	0.7	-0.6
Relative age of first facial hair	0.7	1.4	3.2	1.8	-0.0	0.1	-1.8	-1.8	-0.5	0.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	2.4	0.3	0.1	0.4	-1.0	-1.5	-0.4	0.2
Ever used hormone-replacement therapy (HRT)	1.7	2.2	4.4	-1.3	-1.5	-1.5	1.2	2.1	0.8	-1.5
Ever had hysterectomy (womb removed)	1.0	1.2	3.0	-1.0	-0.9	-0.7	1.7	1.4	0.6	-0.9
Systolic blood pressure, automated reading	2.3	6.6	16.5	1.0	3.7	4.1	-0.2	-1.4	-0.1	3.7
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	1.0	1.0	0.3	0.5	0.3	-0.1	-0.1	0.3
Angina	0.3	0.4	1.4	1.0	-0.2	-0.1	-0.6	-0.2	1.2	-0.3
Medication for hormone replacement therapy	0.3	0.3	0.8	-0.0	-0.7	-0.7	0.1	0.4	-0.9	-0.7
Vitamin and mineral supplements	1.1	1.5	2.5	-1.1	1.2	1.2	1.6	1.5	0.3	1.2
Supplements: Zinc	0.3	0.4	1.7	-0.7	0.0	-0.2	0.2	0.4	-1.3	0.0
Medication: Co-codamol	3.5	4.1	7.3	0.1	-2.3	-2.7	0.8	2.6	1.8	-2.3
Medication: Metformin	1.7	2.4	5.2	-0.6	2.2	2.3	1.2	0.5	-0.5	2.2
Diabetes (father)	0.3	0.4	1.5	0.8	0.3	0.0	1.2	-0.4	0.4	0.3
Diabetes (mother)	0.3	0.3	0.6	0.4	0.7	0.7	-0.4	-0.5	-0.4	0.7
Severe depression (siblings)	2.7	3.0	5.7	1.1	2.4	2.2	-0.4	-1.9	0.3	2.3
Pack years adult smoking proportion	0.7	1.1	3.6	1.9	0.1	0.3	-0.8	-1.6	1.0	0.1
Impedance of leg (right)	0.8	3.9	19.5	1.7	-1.1	-1.4	-0.8	-0.3	4.4	-1.1
Leg fat-free mass (left)	0.6	3.2	10.6	-2.1	-1.6	-1.3	-0.5	0.5	-3.3	-1.6
Trunk fat percentage	0.1	0.5	1.8	0.4	-0.8	-0.5	-0.2	-0.1	-1.3	-0.7
Hand grip strength (right)	0.2	0.6	1.2	0.1	-1.0	-1.1	-0.7	-0.3	-0.3	-1.0
Townsend deprivation index at recruitment	1.7	2.5	8.8	-3.0	-1.0	-0.7	1.1	1.9	-1.0	-1.0
Current tobacco smoking	0.6	0.9	2.0	-0.6	-0.9	-0.8	1.0	1.0	1.4	-0.9
Average weekly fortified wine intake	0.3	0.3	1.5	-0.7	0.3	0.2	0.1	-0.4	-1.2	0.2
Maternal smoking around birth	1.5	2.2	4.3	0.5	-2.1	-1.7	-0.8	0.6	1.7	-2.1
Fed-up feelings	1.9	3.5	7.8	-1.9	-1.4	-1.4	2.8	2.5	0.8	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.3	-0.9	-0.1	-0.1	1.5	1.1	-0.6	-0.1
Relative age voice broke	0.4	0.6	1.1	0.0	-1.1	-1.0	-0.5	-0.3	0.9	-1.0
Taking other prescription medications	0.1	0.2	0.5	-0.5	-0.3	0.3	-0.2	-0.7	-0.6	-0.4
Age when periods started (menarche)	0.4	0.9	4.8	-0.3	-0.6	-0.1	-0.4	-0.5	2.2	-0.6
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	2.9	-1.7	-1.0	-0.9	0.7	0.9	-0.9	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	4.7	0.3	-0.0	-0.1	-0.9	1.9	-2.2	-0.0
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	6.5	-1.0	-1.0	-0.7	2.5	1.6	0.3	-1.0
Qualifications: CSEs or equivalent	2.2	3.0	7.1	-1.4	-1.1	-1.4	2.7	2.7	0.3	-1.1
Serious illness, injury or assault to yourself	0.6	0.8	1.5	-0.2	-1.2	-1.1	-0.9	-0.4	-0.7	-1.2
High blood pressure	4.7	13.2	31.6	1.1	5.1	5.6	-0.6	-1.9	-2.1	5.1
Hayfever, allergic rhinitis or eczema	5.7	12.4	20.7	-1.8	-4.5	-4.5	1.7	3.4	3.2	-4.4
Multivitamins +/- minerals	1.4	1.8	3.9	-0.7	-2.0	-2.0	-0.8	-0.2	-0.0	-2.0
Stomach or abdominal pain in last month	0.1	0.2	0.3	-0.5	-0.5	-0.5	0.0	-0.3	0.2	-0.5
Supplements: Glucosamine	0.9	1.2	1.8	-0.1	-1.2	-1.1	-1.3	-0.6	1.3	-1.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.8	0.5	-0.4	-0.6	-0.7	-0.9	-0.6	-0.5
Medication: Atenolol	2.8	3.5	6.6	1.5	2.6	2.5	0.2	-0.9	1.6	2.5
Medication: Levothyroxine sodium	1.3	2.2	13.8	0.1	0.3	0.6	0.7	-0.6	-3.7	0.3
Sitting height	1.3	8.9	15.1	-3.1	-3.9	-3.7	-0.2	1.9	-2.3	-3.8
Chronic bronchitis/emphysema (father)	1.3	1.6	2.9	-0.1	-1.7	-1.4	-0.6	0.3	1.7	-1.7
High blood pressure (mother)	1.6	2.3	5.2	-1.4	1.5	1.8	0.5	0.7	-2.3	1.5
Body mass index (BMI)	0.2	0.9	5.6	-0.3	-0.5	-0.2	-0.0	0.3	-2.4	-0.4
Impedance of leg (left)	0.8	3.8	18.4	2.1	-0.7	-1.1	-1.1	-0.7	4.3	-0.8
Leg predicted mass (left)	0.6	3.2	10.6	-2.0	-1.7	-1.4	-0.7	0.4	-3.3	-1.6
Trunk fat mass	0.2	0.9	3.2	0.1	-1.1	-0.7	-0.7	-0.2	-1.8	-1.0
Waist circumference	1.2	4.6	17.9	2.1	-0.6	-0.1	-4.2	-2.8	-1.1	-0.5
Number of incorrect matches in round	0.3	0.5	1.6	1.3	0.0	0.3	-0.6	-0.7	-0.9	0.1
Past tobacco smoking	0.5	1.0	1.8	1.0	-1.2	-1.3	-0.9	-0.7	0.3	-1.2
Alcohol usually taken with meals	1.2	2.0	2.6	1.2	1.6	1.4	-1.4	-1.6	0.9	1.6
Nervous feelings	0.8	1.6	4.3	-1.5	-0.6	-0.8	1.6	2.1	0.8	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.5	-0.6	-0.0	-0.4	1.6	1.0	-0.3	-0.1
Hearing difficulty/problems with background noise	0.3	0.5	0.7	0.8	0.8	0.5	0.5	-0.7	0.8	0.8
Hair/balding pattern: Pattern 2	0.3	0.4	1.4	1.2	-0.2	-0.2	0.2	0.2	1.2	-0.1
Had menopause	0.1	0.1	0.2	-0.4	-0.4	-0.2	0.1	0.1	-0.4	-0.4
Had other major operations	1.0	1.2	2.2	-0.5	-1.4	-1.2	0.5	0.3	-1.3	-1.5
Forced vital capacity (FVC)	0.4	1.7	3.3	-1.6	-1.2	-1.4	-0.5	0.9	1.8	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.0	2.9	0.4	-0.5	-0.5	-1.2	1.7	-1.4	-0.5
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.4	-1.1	-1.5	-1.5	0.6	0.5	0.7	-1.5
Qualifications: None of the above	0.6	1.4	4.4	-0.9	-0.8	-0.7	1.1	2.1	1.1	-0.9
Financial difficulties in last 2 years	1.9	2.5	4.3	-1.4	-2.0	-2.0	0.1	1.4	1.0	-2.1
Mouth/teeth dental problems	3.3	5.1	14.7	2.5	1.5	1.3	-2.6	-3.8	-1.4	1.4
Heart attack	0.3	0.3	0.7	0.7	-0.4	-0.6	0.2	0.6	0.9	-0.4
Allergy	8.2	19.0	32.1	3.3	5.6	5.7	-2.7	-4.1	-1.7	5.6
Pain all over the body in last month	0.4	0.4	1.3	1.1	0.5	0.3	0.3	-0.3	-0.8	0.5
Diabetes (self-reported)	0.8	1.2	2.2	-0.4	1.1	1.5	1.3	0.2	-1.4	1.1
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.0	0.1	-1.5	-1.7	-0.7	0.9	0.7	-1.5
Medication: Ramipril	2.5	3.3	6.9	0.7	2.6	2.3	-0.4	-1.5	-0.9	2.6
Medication: Simvastatin	2.7	4.0	8.2	1.2	2.1	2.1	-2.1	-2.9	-0.3	2.1
Fluid intelligence score	0.3	0.7	2.7	-0.6	0.1	0.4	-1.7	-1.0	-0.8	0.1
Illnesses of siblings	0.8	1.1	4.6	1.0	-0.6	-0.8	-0.8	-0.1	2.1	-0.6
Neuroticism score	0.5	1.1	3.5	-0.8	-0.8	-1.0	1.9	1.1	-0.4	-0.8
Weight	0.4	2.1	6.1	-1.0	-1.6	-1.2	-1.2	0.1	-2.5	-1.5
Impedance of arm (right)	0.2	0.9	3.9	0.6	-0.6	-0.9	0.4	-0.3	2.0	-0.6
Arm fat percentage (right)	0.1	0.5	3.2	0.3	-0.3	-0.2	-0.0	0.0	-1.8	-0.3
Trunk fat-free mass	0.6	3.4	5.8	-1.8	-2.2	-1.8	-1.5	0.4	-2.4	-2.1
Hip circumference	0.6	2.8	4.5	-2.1	-1.9	-1.7	0.6	1.2	-1.8	-1.8
Time employed in main current job	0.2	0.3	0.8	0.3	0.5	0.5	0.2	-0.1	-0.9	0.6
Alcohol intake versus 10 years previously	1.3	2.0	2.8	-0.8	-1.6	-1.2	1.6	1.4	1.7	-1.5
Father’s age at death	0.8	1.1	5.6	-2.4	-0.3	-0.3	1.0	0.4	-0.9	-0.3
Worrier / anxious feelings	0.5	0.9	2.8	-1.4	0.8	0.5	1.7	0.0	-0.5	0.8
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	8.8	-3.0	0.3	0.3	2.3	1.5	-0.1	0.3
Falls in the last year	0.1	0.1	0.5	0.3	0.1	-0.1	0.7	-0.1	-0.1	0.2
Hair/balding pattern: Pattern 3	0.3	0.5	0.8	0.8	0.9	0.7	-0.2	-0.2	0.9	0.8
Number of live births	2.4	3.4	11.4	-2.0	-0.8	-0.5	2.5	3.4	-0.2	-0.9
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.4	-1.1	-0.6	-0.8	-0.6	0.9	1.2	-0.6
Pulse rate	2.3	3.8	9.2	0.1	-3.0	-2.7	0.1	0.6	0.8	-3.0
Happiness	0.7	0.8	1.7	0.9	1.3	1.0	0.1	-0.7	-0.1	1.3
Noisy workplace	0.2	0.2	0.7	-0.0	0.5	0.4	0.0	-0.5	0.8	0.4
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.8	-0.1	0.2	0.2	-1.5	-1.9	0.1	0.2
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.4	4.5	1.7	2.1	2.0	-0.8	-0.9	0.1	2.1
Mouth/teeth dental problems: Dentures	2.1	3.6	6.2	-1.9	-1.9	-1.4	1.2	2.5	2.2	-1.8
Asthma	6.8	13.3	21.0	-3.5	-4.5	-4.4	2.7	3.6	0.4	-4.6
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	5.1	-2.3	-1.0	-0.8	1.9	1.7	-0.2	-1.0
Medication: Cholesterol lowering	1.7	2.7	5.2	1.3	1.8	1.7	-1.6	-2.3	-0.0	1.9
Depression (self-reported)	0.1	0.1	0.2	-0.4	-0.0	-0.1	-0.4	-0.3	-0.3	-0.1
Medication: Lansoprazole	0.3	0.4	1.6	-0.9	0.2	0.1	0.3	0.0	1.2	0.2
Prospective memory result	1.1	1.3	3.4	-0.6	-1.0	-0.7	1.4	1.1	-1.8	-1.0
Lung cancer (father)	3.9	4.6	10.7	2.3	-2.1	-2.5	-1.0	0.4	3.3	-2.0
Illnesses of mother	1.0	1.3	2.6	1.6	-0.3	-0.6	-1.6	-1.4	1.1	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.3	-1.5	-1.0	-1.0	-0.2	1.2	0.6	-1.1
Pulse wave Arterial Stiffness index	0.8	0.9	1.5	1.1	1.2	1.2	-0.6	-0.5	-0.0	1.2
Impedance of arm (left)	0.2	0.7	2.4	-0.2	-0.6	-0.8	1.0	0.4	1.5	-0.7
Arm fat mass (right)	0.2	0.8	3.7	-0.3	-0.9	-0.6	-0.5	0.2	-1.9	-0.8
Trunk predicted mass	0.6	3.5	5.6	-1.9	-2.2	-1.8	-1.6	0.5	-2.4	-2.1
Standing height	0.5	4.6	8.6	-1.8	-2.9	-2.6	-2.2	0.2	-0.2	-2.9
Length of working week for main job	0.7	0.8	1.7	1.2	0.7	0.8	-0.6	-1.3	-0.4	0.7
Exposure to tobacco smoke at home	1.8	2.0	5.5	-1.3	-0.5	-0.7	2.4	2.4	0.7	-0.5
Breastfed as a baby	0.9	1.2	2.3	1.5	0.9	1.1	-1.3	-1.0	-0.2	0.9
Tense / ‘highly strung’	0.3	0.4	1.1	-0.7	-0.4	-0.5	0.1	0.8	-1.0	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	3.8	-0.7	-1.8	-2.0	0.7	1.0	-0.1	-1.8
Hair/balding pattern: Pattern 4	0.4	0.9	2.7	-0.1	0.5	0.9	-1.6	-1.4	0.1	0.6
Birth weight of first child	2.0	3.5	6.2	-1.7	-2.1	-2.5	1.6	1.6	-1.0	-2.2
Peak expiratory flow (PEF)	0.0	0.1	0.4	0.2	-0.1	-0.1	-0.3	-0.0	0.6	-0.1
Pulse wave reflection index	0.7	0.9	1.5	0.3	1.2	0.9	-0.7	-1.1	-0.9	1.2
Ever highly irritable/argumentative for 2 days	1.7	2.0	2.8	-0.7	-1.6	-1.6	1.6	1.7	0.0	-1.7
Loud music exposure frequency	1.7	1.9	5.8	0.9	-0.3	-0.5	-2.4	-2.4	0.6	-0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.4	-0.6	0.0	0.2	-0.0	-0.5	-0.1	-0.0
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	2.0	-1.1	-0.8	-1.1	1.4	1.0	-0.2	-0.8
Blood clot in the leg (DVT)	0.5	0.6	1.4	-0.3	-0.9	-1.2	0.6	0.3	-0.9	-1.0
Medication: Paracetamol	0.7	1.1	2.3	-1.5	-0.6	-0.4	1.5	1.0	-1.2	-0.6
Headache pain in last month	0.6	1.1	1.6	-1.3	-1.2	-1.2	0.9	1.0	-0.1	-1.2
Medication for cholesterol, blood pressure or diabetes	6.8	11.2	17.8	-2.8	-4.2	-4.2	2.2	3.7	-0.1	-4.2
Glaucoma (self-reported)	0.7	0.8	1.6	0.1	1.2	1.3	0.7	-0.6	0.4	1.2
Gout (self-reported)	0.0	0.1	0.3	-0.5	-0.1	-0.1	-0.2	0.3	0.0	-0.0
Hypothyroidism/myxoedema (self-reported)	1.6	3.1	13.0	-0.3	1.2	1.3	2.0	-0.0	-3.6	1.2
Medication: Amlodipine	1.2	1.6	3.8	-0.0	1.8	2.0	-0.8	-0.7	-0.3	1.8
Medication: Ventolin 100micrograms inhaler	1.9	2.5	4.3	-1.4	-1.5	-1.4	2.1	2.0	-0.5	-1.5
Birth weight	7.0	15.1	28.3	-2.4	-5.3	-5.2	1.6	3.8	0.7	-5.3
Chronic bronchitis/emphysema (mother)	2.9	3.4	6.1	-0.9	-2.4	-2.5	0.8	1.3	1.8	-2.3
High blood pressure (siblings)	1.1	1.6	6.0	-0.3	1.0	1.1	0.3	-1.5	-2.4	0.9
Forced vital capacity (FVC), Best measure	0.4	1.6	2.5	-1.5	-1.5	-1.5	-0.3	0.9	1.0	-1.6
Body fat percentage	0.1	0.5	1.7	0.5	-0.7	-0.5	-0.3	-0.2	-1.3	-0.6
Leg fat percentage (right)	0.1	0.5	0.7	0.8	-0.8	-0.8	-0.5	-0.2	-0.7	-0.8
Arm fat-free mass (right)	0.4	2.1	5.7	-1.4	-1.4	-1.1	-1.5	0.2	-2.4	-1.4
Exposure to tobacco smoke outside home	0.2	0.2	0.4	-0.3	0.7	0.3	0.6	0.0	-0.3	0.7
Comparative body size at age 10	0.1	0.3	0.7	0.7	0.4	0.6	-0.1	-0.8	0.2	0.5
Number of full brothers	1.7	2.1	3.2	-0.9	-1.6	-1.7	1.0	1.3	-1.8	-1.6
Worry too long after embarrassment	0.2	0.3	0.8	-0.2	0.6	0.6	0.2	-0.2	-0.9	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.0	3.6	-1.9	-1.7	-1.2	-0.6	0.2	1.8	-1.7
Wheeze or whistling in the chest in last year	9.2	16.4	31.9	-2.7	-5.7	-5.3	2.1	2.8	1.8	-5.6
Number of children fathered	1.5	1.7	2.8	1.7	-1.2	-1.5	-1.4	-0.0	1.5	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.3	1.1	0.1	0.2	-0.6	-0.2	-0.6	0.0
Age at first live birth	2.6	4.5	9.1	2.7	1.9	1.6	-2.3	-3.0	0.3	1.9
Pulse wave peak to peak time	1.1	1.3	2.1	-1.4	-1.4	-1.4	0.6	0.7	-0.2	-1.4
Health satisfaction	0.8	1.1	2.2	-0.6	-1.5	-1.5	-0.7	0.1	0.4	-1.5
Shortness of breath walking on level ground	3.4	4.0	8.2	-2.9	-1.2	-1.1	2.7	2.7	-1.0	-1.2
Qualifications: College or University degree	2.2	6.8	16.8	1.6	2.2	2.4	-3.2	-4.1	-1.5	2.3
Eye problems/disorders: None of the above	1.2	1.4	2.5	-0.5	-1.4	-1.3	0.0	1.4	-1.6	-1.3
Mouth/teeth dental problems: Loose teeth	2.4	2.8	4.0	-1.9	-2.0	-1.6	0.6	1.7	1.8	-1.9
Emphysema/chronic bronchitis	2.0	2.3	4.5	-1.5	-2.1	-1.4	0.3	0.6	-1.6	-2.1
Medication for pain relief, constipation, heartburn	0.3	0.5	1.5	1.1	0.6	0.2	-0.6	-0.3	1.2	0.6
Neck or shoulder pain in last month	0.7	0.9	2.2	-0.4	-1.3	-1.5	0.6	0.5	-0.4	-1.3
Medication: Blood pressure	5.4	9.5	18.9	2.3	4.1	4.3	-1.1	-2.5	-0.9	4.1
Angina (self-reported)	0.2	0.3	1.1	0.7	-0.4	-0.2	-0.3	0.1	1.1	-0.5
Migraine (self-reported)	0.1	0.1	0.4	0.3	-0.1	0.1	-0.3	-0.1	0.6	-0.0
Medication: Ibuprofen	2.0	2.4	5.0	-2.2	-1.3	-1.1	1.6	2.1	0.8	-1.3
Medication: Allopurinol	0.3	0.3	0.9	-0.9	0.6	0.5	-0.0	0.6	-0.4	0.7
Medication: Omeprazole	0.8	0.9	3.0	1.0	0.3	0.4	-1.7	-1.1	-1.0	0.3
Medication: Seretide 50 evohaler	2.0	2.3	7.9	-2.2	-0.4	-0.1	2.8	1.8	-0.1	-0.4
Mean time to correctly identify matches	3.8	7.3	13.7	2.4	3.7	3.2	0.1	-2.2	-1.8	3.7
Heart disease (mother)	1.6	1.9	2.9	-1.1	1.3	1.6	1.7	0.4	-1.7	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	3.3	-1.8	-0.1	-0.1	1.4	1.3	0.6	-0.0
Whole body fat mass	0.2	0.9	3.3	-0.2	-1.1	-0.8	-0.5	0.2	-1.8	-1.0
Leg fat mass (right)	0.2	0.8	2.2	0.3	-1.0	-0.8	-0.8	-0.2	-1.5	-1.0
Arm predicted mass (right)	0.5	2.5	6.4	-1.8	-1.6	-1.2	-1.1	0.5	-2.5	-1.5
Pulse rate, automated reading	3.3	10.7	23.0	-0.0	-4.8	-4.6	-1.1	0.9	2.6	-4.7
Alcohol intake frequency.	0.6	1.3	5.2	-1.1	0.5	0.5	2.3	1.4	-0.3	0.6
Comparative height size at age 10	0.8	4.5	9.4	-1.6	-3.1	-2.9	-1.1	0.8	-0.3	-3.0
Number of full sisters	0.6	0.7	1.4	-1.1	-0.6	-0.4	1.2	1.2	0.5	-0.6
Suffer from ‘nerves’	2.9	4.5	9.6	-1.3	-1.9	-2.3	3.1	2.9	-0.2	-1.9
Overall health rating	0.6	1.4	2.1	-0.6	-1.4	-1.2	1.3	1.4	0.8	-1.3
Chest pain or discomfort	0.8	1.1	4.8	-0.1	-0.6	-1.0	2.2	0.8	0.4	-0.7
Had major operations	0.2	0.2	0.9	0.9	-0.2	0.0	-0.4	-0.5	-0.1	-0.2
Age at last live birth	0.7	1.0	2.9	1.7	1.1	0.7	-0.1	-0.7	-0.3	1.2
Family relationship satisfaction	0.3	0.4	0.9	-0.8	0.5	0.7	0.3	-1.0	0.3	0.5
Leg pain on walking	0.5	0.6	2.7	0.8	-0.2	0.1	-1.6	-0.6	-0.4	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.1	0.0	-0.1	-0.5	1.0	0.9	-1.1	-0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.4	1.2	-0.1	-0.4	0.2	-0.8	-0.6	-0.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	0.9	-0.4	-1.0	-0.6	-0.5	0.2	0.7	-0.9
Medication: Aspirin	2.8	3.7	6.2	1.9	2.0	2.3	-1.7	-2.5	-0.4	2.1
Supplements: Vitamin C	0.6	0.7	1.9	1.0	0.3	0.4	-0.9	-1.4	-1.0	0.4
Knee pain experienced in last month	0.4	0.6	1.1	-0.3	-1.1	-1.0	0.3	0.9	0.2	-1.0
Hypertension (Self-reported)	5.5	15.4	36.1	1.2	5.5	6.0	-0.8	-2.4	-2.0	5.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.6	-0.4	-0.5	-1.1	0.4	1.2	-0.1	-0.6
Illnesses of father: Heart disease	4.3	5.9	10.8	0.8	2.8	2.7	-3.3	-2.7	-0.3	2.8
Illnesses of siblings: Diabetes	0.9	1.1	3.0	-0.9	-0.6	-0.6	1.5	1.7	-0.8	-0.7
Smoking status: Previous	0.9	1.4	2.9	-0.5	1.6	1.7	0.7	0.5	-0.8	1.6
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	6.4	-0.5	-2.5	-2.2	-1.5	0.4	1.0	-2.5
Whole body fat-free mass	0.6	3.4	7.8	-2.0	-2.0	-1.6	-1.2	0.4	-2.8	-2.0
Leg fat-free mass (right)	0.6	3.1	11.8	-1.9	-1.5	-1.2	-0.7	0.3	-3.4	-1.4
Arm fat percentage (left)	0.2	0.7	4.2	-0.2	-0.4	-0.3	0.4	0.4	-2.0	-0.3
Average weekly red wine intake	1.9	2.8	4.7	2.2	2.0	1.5	-0.8	-1.8	-1.2	1.9
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.1	-0.2	0.2	0.2	-0.7	-1.4	-1.4	0.2
Mood swings	0.1	0.2	0.5	0.4	-0.4	-0.7	0.2	0.3	0.6	-0.4
Loneliness, isolation	0.4	0.6	2.1	-1.5	0.2	0.1	0.4	0.3	-1.4	0.3
Long-standing illness, disability or infirmity	0.5	0.8	2.2	-1.5	-0.7	-0.4	0.9	-0.2	-1.1	-0.7
Ever had bowel cancer screening	4.5	5.3	9.6	1.0	2.6	3.1	-1.3	-2.4	-2.4	2.6
Diabetes diagnosed by doctor	1.4	2.4	4.7	0.3	1.8	2.2	0.6	-0.6	-2.1	1.9
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.2	7.2	0.6	-1.5	-1.5	-2.7	-1.2	0.2	-1.4
Friendships satisfaction	0.1	0.1	0.2	-0.5	0.2	-0.1	0.4	0.5	-0.2	0.2
Qualifications: nursing, teaching	0.7	1.1	4.8	0.7	-0.1	-0.1	-1.6	-2.2	0.1	-0.1
Commuting to job workplace: Walk	0.6	0.6	1.7	-0.7	0.6	1.0	-0.5	-0.7	-1.3	0.6
Eye problems/disorders: Cataract	0.8	0.9	2.6	0.7	0.7	0.4	-1.5	-1.6	0.3	0.6
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	5.1	-1.1	0.6	0.6	1.4	2.3	0.3	0.5
Medication for cholesterol	1.8	2.7	5.9	0.2	-2.0	-2.4	0.3	1.5	1.4	-2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.5	0.9	0.3	0.5	-1.6	-1.4	-1.2	0.3
Back pain experienced in last month	1.0	1.5	2.1	-1.5	-1.4	-1.2	0.9	1.4	0.5	-1.4
Mineral and other dietary supplements	0.4	0.6	1.2	-0.3	-0.3	-0.6	1.1	1.1	-0.9	-0.2
Breast cancer (self-reported)	0.9	1.1	2.9	-0.1	-0.1	0.2	-1.5	-1.6	-1.7	-0.0
Asthma (self-reported)	6.1	12.1	17.5	-3.4	-4.1	-4.0	2.9	3.7	0.5	-4.2
Osteoporosis (self-reported)	0.6	0.8	3.7	-0.6	0.6	0.6	-0.0	-1.9	-0.6	0.6
Osteoarthritis (self-reported)	4.5	5.8	12.0	0.0	-3.4	-3.5	1.2	2.1	0.4	-3.4
Medication: Aspirin	3.7	4.8	7.6	2.1	2.5	2.8	-1.8	-2.4	0.2	2.6
Medication: Gliclazide	2.9	3.3	7.7	0.1	2.7	2.7	0.6	-0.2	-0.3	2.8
Illnesses of father: None of the above (group 1)	2.1	2.6	5.8	-0.8	-1.6	-1.6	1.9	2.4	-0.1	-1.7
Smoking status: Current	0.7	1.2	2.5	-0.8	-1.1	-0.9	1.1	0.9	1.6	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	2.6	1.0	0.2	0.3	-1.6	-0.2	0.1	0.2
Whole body water mass	0.6	3.2	7.0	-1.9	-2.0	-1.6	-1.3	0.4	-2.6	-1.9
Leg predicted mass (right)	0.6	3.1	12.1	-1.9	-1.5	-1.1	-0.7	0.3	-3.5	-1.4
Arm fat mass (left)	0.2	1.0	4.5	-0.5	-1.0	-0.7	-0.2	0.4	-2.1	-0.9
Number of self-reported non-cancer illnesses	0.5	0.9	5.2	-0.3	-0.2	0.3	-0.6	-0.4	-2.3	-0.2
Average weekly champagne plus white wine intake	0.1	0.2	1.0	-0.1	0.1	-0.0	-1.0	-0.1	0.6	0.1
Miserableness	1.9	3.3	8.9	-2.4	-0.1	-0.3	2.3	1.6	-3.0	-0.2
Guilty feelings	0.2	0.3	0.8	-0.8	0.3	0.4	0.9	-0.4	0.3	0.3
Wears glasses or contact lenses	4.1	4.7	8.1	2.0	2.4	2.0	-2.3	-2.8	0.4	2.3
Ever taken oral contraceptive pill	1.4	1.6	3.3	-1.0	-1.3	-1.2	1.1	1.8	-0.2	-1.4
Hearing aid user	0.4	0.5	0.8	0.9	0.7	0.7	-0.1	0.8	0.8	0.7
Mother’s age at death	0.4	0.5	2.2	0.5	0.2	0.4	-0.7	0.4	1.5	0.3
Financial situation satisfaction	1.4	1.7	4.1	-0.3	-2.0	-1.6	0.2	0.2	-1.2	-2.0
Tinnitus: Yes, now most or all of the time	1.2	1.5	2.4	-1.1	-1.3	-1.5	-1.6	-0.8	0.5	-1.3
Commuting to job workplace: Public transport	0.4	0.5	1.3	-0.0	-1.0	-1.2	0.1	0.1	-0.2	-1.0
Eye problems/disorders: Glaucoma	0.3	0.4	1.7	0.2	0.3	0.4	0.5	-0.6	1.3	0.2
Medication: Blood pressure	5.7	10.9	24.1	1.1	4.7	4.9	-0.7	-2.6	-0.3	4.7
Pain type(s) experienced in last month: Hip pain	1.3	1.7	3.8	-1.0	-1.9	-1.9	0.1	0.2	-0.3	-1.9
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.9	-1.7	-0.7	-0.2	0.8	1.0	-0.5	-0.7
High cholesterol (Self-reported)	2.0	3.6	7.6	0.4	2.0	2.4	-1.6	-2.8	-0.4	2.1
Medication: Bendroflumethiazide	4.4	6.7	15.4	0.3	3.9	3.9	0.9	-0.5	-0.5	3.9
Medication: Paracetamol	0.8	1.2	3.0	-1.7	-0.6	-0.2	1.5	1.2	-1.0	-0.6
Medication: Lisinopril	3.5	4.5	8.5	0.7	2.9	2.9	-1.2	-2.1	-0.6	2.8
Medication: Atorvastatin	0.5	0.7	3.5	-0.3	0.6	0.5	-0.0	-0.3	-1.9	0.6
Illnesses of father: High blood pressure	1.2	1.5	2.9	-0.3	1.7	1.4	0.0	-1.1	-1.2	1.7
Alcohol drinker status: Never	0.4	0.5	1.1	-0.1	-0.9	-1.1	0.4	0.6	0.2	-1.0
Ever smoked	0.6	1.0	2.6	-1.4	0.4	0.6	1.6	1.3	0.5	0.4
Basal metabolic rate	0.6	3.4	7.3	-1.8	-2.0	-1.7	-1.3	0.4	-2.7	-2.0
Leg fat percentage (left)	0.1	0.5	1.1	1.0	-0.5	-0.5	-0.7	-0.5	-0.9	-0.5
Arm fat-free mass (left)	0.4	2.1	3.3	-1.1	-1.7	-1.4	-1.7	0.1	-1.8	-1.6
Number of operations (self-reported)	0.5	0.7	1.0	0.9	-0.9	-0.9	-1.0	-0.7	0.4	-1.0
Average weekly beer plus cider intake	0.4	0.6	1.6	0.6	-0.9	-0.8	-1.3	0.0	0.4	-0.9
Irritability	0.5	0.8	3.3	1.8	0.3	0.0	-1.0	-0.8	-0.6	0.3
Risk taking	1.0	1.4	6.2	0.7	-0.3	0.2	-2.5	-1.7	0.1	-0.3
Ever had prostate specific antigen (PSA) test	2.6	3.0	7.7	1.4	1.5	1.5	-2.1	-2.8	-0.7	1.5
Fractured/broken bones in last 5 years	2.3	2.9	5.2	1.8	-1.4	-1.9	-2.3	-1.2	1.8	-1.4
Age started oral contraceptive pill	0.2	0.3	1.0	0.8	0.2	0.2	-0.4	0.1	1.0	0.3
Diastolic blood pressure, automated reading	1.3	3.9	9.1	-1.5	2.6	3.0	-0.1	-1.1	-1.3	2.6
Ever depressed for a whole week	0.7	0.9	1.6	-0.4	-1.3	-1.1	0.9	0.6	0.7	-1.2
Unable to work because of sickness or disability	1.6	2.1	4.6	-1.1	-2.1	-1.9	-0.5	0.7	-0.0	-2.1
Commuting to job workplace: Cycle	0.4	0.5	3.1	-0.2	0.1	0.4	-1.8	-0.6	0.2	0.2
Myopia	2.5	3.6	6.4	1.1	2.4	2.5	-1.4	-2.0	-0.8	2.4
Vascular/heart problems diagnosed by doctor	4.2	11.5	26.7	-1.5	-4.7	-5.2	1.0	2.3	1.4	-4.7
Cholesterol lowering medication	0.6	0.9	3.0	0.8	-0.1	0.1	-1.7	-1.5	-0.5	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.3	1.0	0.1	0.1	-1.5	-0.8	-1.4	0.0
Pain experienced in last month	0.8	1.4	2.4	1.0	1.2	1.3	-1.5	-1.3	0.4	1.2
Supplements: Calcium	1.2	1.3	3.4	0.5	-1.1	-0.9	-1.4	-1.9	-0.4	-1.1
Basal cell carcinoma (self-reported)	1.5	1.8	3.0	1.2	1.2	1.1	-1.7	-1.7	1.2	1.2
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.6	0.7	-0.2	-0.5	0.1	0.5	0.8	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.9	-0.2	-0.5	-0.7	0.5	0.1	-1.0	-0.5
Heart disease (siblings)	1.1	1.3	3.1	-1.8	0.7	1.1	1.6	1.2	-0.4	0.7
Alcohol drinker status: Previous	0.3	0.3	0.8	-0.8	0.3	0.3	0.5	0.9	0.6	0.3
Pack years of smoking	1.1	1.6	5.2	2.3	0.5	0.7	-0.7	-1.7	1.1	0.6
Impedance of whole body	0.3	1.6	7.9	0.9	-0.7	-1.0	0.3	-0.1	2.8	-0.8
Leg fat mass (left)	0.2	0.7	2.7	0.3	-0.8	-0.6	-0.9	-0.3	-1.6	-0.7
Arm predicted mass (left)	0.6	2.8	4.2	-1.4	-2.1	-1.7	-1.8	0.4	-1.9	-2.0