Hub : Genes

CRYAB

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Heart Atrial Appendage 0.1280 0.0600 7.5e-03 -0.002 NA -0.006 NA -0.006 4.3e-01 NA 9.5e-01 NA 7.3e-01
2 GTEx Skin Not Sun Exposed Suprapubic 0.1200 0.0470 5.3e-04 0.104 NA 0.059 NA 0.073 2.6e-06 NA 3.7e-04 NA 7.7e-05
3 GTEx Skin Sun Exposed Lower leg 0.0700 0.0310 1.3e-03 0.042 NA 0.005 NA 0.017 2.2e-04 NA 1.2e-01 NA 1.3e-02
4 METSIM Adipose 0.0342 0.0145 8.7e-05 0.031 0.029 0.025 0.027 0.024 1.5e-05 3.2e-05 1.1e-04 4.7e-05 1.5e-04
5 ROSMAP Brain Pre-frontal Cortex 0.0331 0.0164 7.7e-03 0.001 0.009 0.001 0.006 0.002 2.0e-01 2.3e-02 2.1e-01 5.5e-02 1.4e-01
6 YFS Blood 0.0166 0.0106 1.3e-02 0.002 0.006 0.014 0.008 0.007 8.2e-02 4.4e-03 1.3e-05 9.5e-04 1.9e-03
7 TCGA Breast Invasive Carcinoma 0.0269 0.0168 1.7e-03 0.015 0.011 0.009 NA 0.011 3.5e-04 2.2e-03 5.2e-03 NA 2.2e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 2.4 3.8 8.3 2.1 1.8 1.7 -2.0 -2.9 -0.6 1.8
Bipolar Disorder or Schizophrenia 1.1 2.7 7.6 1.7 1.6 1.7 -0.4 -2.8 -0.8 1.6
Depressed Affect (Nagel 2018) 0.3 0.7 1.8 -1.0 -0.4 -0.6 1.3 1.0 -0.5 -0.4
Depression (Nagel 2018) 0.7 1.1 1.9 -1.1 1.0 1.1 1.0 -0.1 -1.4 1.0
Intelligence (Savage-Jansen 2018) 0.3 0.9 2.0 -0.4 -1.3 -1.3 0.3 0.8 -0.1 -1.4
Neuroticism (Nagel 2018) 0.3 0.6 2.3 -0.9 -0.1 -0.0 1.5 1.0 -0.2 0.1
Schizophrenia (2018) 0.3 0.6 1.4 0.5 0.6 0.7 1.0 -1.2 -0.4 0.6
Schizophrenia vs Biploar Disorder 1.1 1.4 3.0 -0.8 -1.2 -1.2 1.7 1.4 -0.1 -1.2
Worry (Nagel 2018) 0.2 0.5 1.6 -0.8 -0.3 -0.5 1.2 0.8 -0.2 -0.3
Alzheimer’s Disease (in mother) 1.4 1.6 4.9 2.0 -0.1 -0.3 -2.2 -1.6 0.3 -0.1
Alzheimer’s Disease (in father) 0.5 0.5 1.2 0.5 -0.7 -0.5 -0.3 -0.9 1.1 -0.7
Alzheimer’s Disease (including proxy) 1.6 2.3 7.1 1.8 -0.5 -1.0 -2.7 -2.0 0.3 -0.5
Crohns Disease (2017) 0.7 1.5 3.4 -1.9 -1.1 -1.3 1.1 1.2 -0.4 -1.2
Irritable Bowel Disease (IBD) 0.5 1.2 3.4 -0.6 1.3 1.1 1.9 0.3 -0.5 1.2
Ulcerative Colitis (UC) 2.2 4.1 8.8 0.5 3.0 2.9 1.6 -0.4 -0.6 2.8
Major Depression (MDD) 0.3 0.3 1.4 -0.0 0.2 0.3 1.2 -0.0 -0.9 0.2
Reaction Time 2.6 4.9 7.9 2.0 2.8 2.4 -0.7 -2.4 -1.7 2.8
Verbal and Numeric Reasoning (VNR) 0.1 0.2 1.2 -1.1 -0.2 -0.0 -0.1 0.4 0.3 -0.2
Breast Cancer 2.3 5.6 9.9 0.1 2.7 3.1 2.4 0.6 -3.0 2.7
Ovarian Cancer 1.0 1.3 3.5 -1.9 1.3 1.1 1.1 0.1 -0.4 1.3
Prostate Cancer 1.2 1.7 4.0 -0.5 1.5 1.8 0.1 -0.0 -2.0 1.5
Age at First Birth 1.2 1.8 6.2 1.1 0.3 0.3 -2.1 -2.5 -0.9 0.3
Bipolar Disorder (2011) 1.2 1.2 4.5 0.4 1.9 0.0 0.0 -2.1 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.6 2.6 -0.4 -0.7 -0.4 -0.2 -0.4 -1.6 -1.0
Coronary Artery Disease (CAD) 2.3 2.7 5.1 0.8 2.0 1.8 -1.5 -1.4 -1.3 2.3
Crohns Disease (2012) 0.3 0.5 1.0 -1.0 -0.7 -1.0 0.1 -0.4 -0.6 -0.7
Mean Putamen Volume 0.5 0.5 1.1 0.3 -1.1 -0.8 0.4 0.7 0.4 -1.0
Fasting Glucose 0.3 0.4 1.0 0.2 -0.8 -1.0 0.1 0.9 -0.2 -0.3
HbA1C 0.7 0.8 4.1 0.2 0.4 0.6 0.1 -0.7 -2.0 0.8
HDL Cholesterol 2.5 4.1 14.5 -2.5 0.0 -0.0 3.8 2.7 0.9 -0.2
LDL Cholesterol 0.1 0.2 0.8 0.4 -0.4 0.1 -0.5 -0.0 -0.9 -0.4
Lupus 1.8 2.8 5.5 0.1 2.1 1.9 0.1 -1.3 -2.3 2.1
Neuroticism (2016) 1.1 1.6 4.3 -2.1 -1.1 -1.2 1.3 0.8 0.5 -1.2
Primary Biliary Cirrhosis 3.5 5.0 8.2 1.4 2.8 2.5 -1.4 -2.8 -0.9 2.9
Rheumatoid Arthritis 0.3 0.4 1.4 1.1 0.1 -0.4 -0.1 -0.7 1.2 0.1
Schizophrenia (2014) 0.3 0.7 2.7 0.9 0.1 0.3 0.3 -1.6 -0.9 0.1
Triglycerides 0.6 1.0 2.6 0.5 -1.0 -1.1 -1.2 0.5 0.3 -1.6
Type 2 Diabetes (T2D) (2012) 0.9 1.0 2.1 0.7 0.7 0.8 -0.3 -1.4 -1.5 1.2
Ulcerative Colitis 0.7 1.0 2.2 0.2 1.3 1.5 0.4 -1.2 0.5 1.2
Blood Eosinophil Count 1.4 10.9 22.8 1.9 3.6 3.6 -0.6 -3.3 -4.8 3.6
Blood Platelet Count 0.7 8.2 14.8 0.9 -3.3 -3.9 2.6 1.9 3.1 -3.3
Blood Red Count 0.7 7.2 20.2 1.0 -1.9 -1.2 -4.5 -3.4 3.1 -1.8
Blood White Count 0.3 2.1 5.3 2.3 -0.9 -0.8 -0.8 -2.1 1.4 -0.8
Heel T-Score 1.1 8.8 32.1 0.7 0.1 -0.1 -1.4 5.2 -5.7 0.0
BMI 0.2 1.3 5.0 0.8 -0.7 -0.5 -1.1 -0.9 -2.2 -0.6
Height 0.6 12.2 25.1 -2.6 -5.0 -4.4 -2.2 2.0 0.9 -5.0
Waist Hip Ratio (WHR) 9.7 43.7 139.2 8.6 1.2 1.3 -11.8 -9.3 1.2 1.3
Systolic Blood Pressure 4.1 20.7 49.3 1.6 6.6 7.0 -0.1 -2.7 -0.1 6.5
Smoking Status 0.7 1.6 5.5 -1.5 0.7 0.9 2.4 1.4 0.0 0.7
Allergy or Eczema 5.6 14.6 25.6 -1.4 -5.0 -5.1 1.7 3.6 3.1 -4.9
Cardiovascular Disease 5.5 18.2 40.2 1.5 5.8 6.3 -1.3 -3.6 -1.8 5.8
Hypothyroidism (self reported) 1.3 3.1 10.0 -0.5 1.4 1.5 2.2 -0.6 -3.2 1.4
Respiratory disease 4.3 9.5 18.4 -1.7 -4.2 -4.1 1.7 2.7 -0.0 -4.3
Type 2 Diabetes (T2D) (2018) 0.5 1.0 1.8 -0.5 1.0 1.3 0.9 0.1 -1.3 1.0
Lung FEV1/FVC ratio 0.2 0.8 1.5 0.4 -1.0 -0.7 0.5 1.1 -1.2 -0.9
Lung FVC 0.5 2.6 6.0 0.2 2.4 2.5 -0.1 -0.3 0.9 2.4
Neuroticism 0.5 1.2 4.1 -0.4 1.0 0.9 2.0 0.6 -1.1 0.9
Chronotype (morning person) 0.0 0.1 0.5 0.7 0.3 0.1 0.1 -0.1 -0.1 0.3
Hair Pigment 0.2 6.3 13.3 0.6 3.4 3.6 2.2 -0.2 -1.9 3.3
Tanning 0.1 1.3 3.6 1.0 0.0 -0.7 -1.9 -1.2 -1.5 0.1
Hand grip strength (left) 0.6 1.5 3.0 0.2 -1.5 -1.7 -1.3 -0.9 -0.7 -1.6
Number of treatments/medications taken 0.5 1.0 2.9 -0.7 1.1 1.7 -0.1 -0.6 -0.8 1.1
Average weekly spirits intake 0.4 0.5 2.5 -0.0 0.3 0.3 0.7 0.4 -1.6 0.2
Sensitivity / hurt feelings 2.3 4.0 7.7 -1.3 -2.7 -2.7 1.6 1.4 -0.3 -2.8
Frequency of depressed mood in last 2 weeks 0.7 1.0 1.8 -0.9 1.0 1.1 0.9 -0.1 -1.4 1.0
Hearing difficulty/problems: Yes 0.2 0.3 0.5 0.5 -0.5 -0.7 0.3 0.2 0.7 -0.6
Relative age of first facial hair 0.7 1.4 3.2 1.8 -0.0 0.1 -1.8 -1.8 -0.5 0.0
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 2.4 0.3 0.1 0.4 -1.0 -1.5 -0.4 0.2
Ever used hormone-replacement therapy (HRT) 1.7 2.2 4.4 -1.3 -1.5 -1.5 1.2 2.1 0.8 -1.5
Ever had hysterectomy (womb removed) 1.0 1.2 3.0 -1.0 -0.9 -0.7 1.7 1.4 0.6 -0.9
Systolic blood pressure, automated reading 2.3 6.6 16.5 1.0 3.7 4.1 -0.2 -1.4 -0.1 3.7
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 1.0 1.0 0.3 0.5 0.3 -0.1 -0.1 0.3
Angina 0.3 0.4 1.4 1.0 -0.2 -0.1 -0.6 -0.2 1.2 -0.3
Medication for hormone replacement therapy 0.3 0.3 0.8 -0.0 -0.7 -0.7 0.1 0.4 -0.9 -0.7
Vitamin and mineral supplements 1.1 1.5 2.5 -1.1 1.2 1.2 1.6 1.5 0.3 1.2
Supplements: Zinc 0.3 0.4 1.7 -0.7 0.0 -0.2 0.2 0.4 -1.3 0.0
Medication: Co-codamol 3.5 4.1 7.3 0.1 -2.3 -2.7 0.8 2.6 1.8 -2.3
Medication: Metformin 1.7 2.4 5.2 -0.6 2.2 2.3 1.2 0.5 -0.5 2.2
Diabetes (father) 0.3 0.4 1.5 0.8 0.3 0.0 1.2 -0.4 0.4 0.3
Diabetes (mother) 0.3 0.3 0.6 0.4 0.7 0.7 -0.4 -0.5 -0.4 0.7
Severe depression (siblings) 2.7 3.0 5.7 1.1 2.4 2.2 -0.4 -1.9 0.3 2.3
Pack years adult smoking proportion 0.7 1.1 3.6 1.9 0.1 0.3 -0.8 -1.6 1.0 0.1
Impedance of leg (right) 0.8 3.9 19.5 1.7 -1.1 -1.4 -0.8 -0.3 4.4 -1.1
Leg fat-free mass (left) 0.6 3.2 10.6 -2.1 -1.6 -1.3 -0.5 0.5 -3.3 -1.6
Trunk fat percentage 0.1 0.5 1.8 0.4 -0.8 -0.5 -0.2 -0.1 -1.3 -0.7
Hand grip strength (right) 0.2 0.6 1.2 0.1 -1.0 -1.1 -0.7 -0.3 -0.3 -1.0
Townsend deprivation index at recruitment 1.7 2.5 8.8 -3.0 -1.0 -0.7 1.1 1.9 -1.0 -1.0
Current tobacco smoking 0.6 0.9 2.0 -0.6 -0.9 -0.8 1.0 1.0 1.4 -0.9
Average weekly fortified wine intake 0.3 0.3 1.5 -0.7 0.3 0.2 0.1 -0.4 -1.2 0.2
Maternal smoking around birth 1.5 2.2 4.3 0.5 -2.1 -1.7 -0.8 0.6 1.7 -2.1
Fed-up feelings 1.9 3.5 7.8 -1.9 -1.4 -1.4 2.8 2.5 0.8 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 2.3 -0.9 -0.1 -0.1 1.5 1.1 -0.6 -0.1
Relative age voice broke 0.4 0.6 1.1 0.0 -1.1 -1.0 -0.5 -0.3 0.9 -1.0
Taking other prescription medications 0.1 0.2 0.5 -0.5 -0.3 0.3 -0.2 -0.7 -0.6 -0.4
Age when periods started (menarche) 0.4 0.9 4.8 -0.3 -0.6 -0.1 -0.4 -0.5 2.2 -0.6
Bilateral oophorectomy (both ovaries removed) 1.0 1.1 2.9 -1.7 -1.0 -0.9 0.7 0.9 -0.9 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 4.7 0.3 -0.0 -0.1 -0.9 1.9 -2.2 -0.0
Tinnitus: Yes, but not now, but have in the past 1.7 1.8 6.5 -1.0 -1.0 -0.7 2.5 1.6 0.3 -1.0
Qualifications: CSEs or equivalent 2.2 3.0 7.1 -1.4 -1.1 -1.4 2.7 2.7 0.3 -1.1
Serious illness, injury or assault to yourself 0.6 0.8 1.5 -0.2 -1.2 -1.1 -0.9 -0.4 -0.7 -1.2
High blood pressure 4.7 13.2 31.6 1.1 5.1 5.6 -0.6 -1.9 -2.1 5.1
Hayfever, allergic rhinitis or eczema 5.7 12.4 20.7 -1.8 -4.5 -4.5 1.7 3.4 3.2 -4.4
Multivitamins +/- minerals 1.4 1.8 3.9 -0.7 -2.0 -2.0 -0.8 -0.2 -0.0 -2.0
Stomach or abdominal pain in last month 0.1 0.2 0.3 -0.5 -0.5 -0.5 0.0 -0.3 0.2 -0.5
Supplements: Glucosamine 0.9 1.2 1.8 -0.1 -1.2 -1.1 -1.3 -0.6 1.3 -1.2
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 0.8 0.5 -0.4 -0.6 -0.7 -0.9 -0.6 -0.5
Medication: Atenolol 2.8 3.5 6.6 1.5 2.6 2.5 0.2 -0.9 1.6 2.5
Medication: Levothyroxine sodium 1.3 2.2 13.8 0.1 0.3 0.6 0.7 -0.6 -3.7 0.3
Sitting height 1.3 8.9 15.1 -3.1 -3.9 -3.7 -0.2 1.9 -2.3 -3.8
Chronic bronchitis/emphysema (father) 1.3 1.6 2.9 -0.1 -1.7 -1.4 -0.6 0.3 1.7 -1.7
High blood pressure (mother) 1.6 2.3 5.2 -1.4 1.5 1.8 0.5 0.7 -2.3 1.5
Body mass index (BMI) 0.2 0.9 5.6 -0.3 -0.5 -0.2 -0.0 0.3 -2.4 -0.4
Impedance of leg (left) 0.8 3.8 18.4 2.1 -0.7 -1.1 -1.1 -0.7 4.3 -0.8
Leg predicted mass (left) 0.6 3.2 10.6 -2.0 -1.7 -1.4 -0.7 0.4 -3.3 -1.6
Trunk fat mass 0.2 0.9 3.2 0.1 -1.1 -0.7 -0.7 -0.2 -1.8 -1.0
Waist circumference 1.2 4.6 17.9 2.1 -0.6 -0.1 -4.2 -2.8 -1.1 -0.5
Number of incorrect matches in round 0.3 0.5 1.6 1.3 0.0 0.3 -0.6 -0.7 -0.9 0.1
Past tobacco smoking 0.5 1.0 1.8 1.0 -1.2 -1.3 -0.9 -0.7 0.3 -1.2
Alcohol usually taken with meals 1.2 2.0 2.6 1.2 1.6 1.4 -1.4 -1.6 0.9 1.6
Nervous feelings 0.8 1.6 4.3 -1.5 -0.6 -0.8 1.6 2.1 0.8 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 2.5 -0.6 -0.0 -0.4 1.6 1.0 -0.3 -0.1
Hearing difficulty/problems with background noise 0.3 0.5 0.7 0.8 0.8 0.5 0.5 -0.7 0.8 0.8
Hair/balding pattern: Pattern 2 0.3 0.4 1.4 1.2 -0.2 -0.2 0.2 0.2 1.2 -0.1
Had menopause 0.1 0.1 0.2 -0.4 -0.4 -0.2 0.1 0.1 -0.4 -0.4
Had other major operations 1.0 1.2 2.2 -0.5 -1.4 -1.2 0.5 0.3 -1.3 -1.5
Forced vital capacity (FVC) 0.4 1.7 3.3 -1.6 -1.2 -1.4 -0.5 0.9 1.8 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.0 2.9 0.4 -0.5 -0.5 -1.2 1.7 -1.4 -0.5
Ever unenthusiastic/disinterested for a whole week 1.1 1.3 2.4 -1.1 -1.5 -1.5 0.6 0.5 0.7 -1.5
Qualifications: None of the above 0.6 1.4 4.4 -0.9 -0.8 -0.7 1.1 2.1 1.1 -0.9
Financial difficulties in last 2 years 1.9 2.5 4.3 -1.4 -2.0 -2.0 0.1 1.4 1.0 -2.1
Mouth/teeth dental problems 3.3 5.1 14.7 2.5 1.5 1.3 -2.6 -3.8 -1.4 1.4
Heart attack 0.3 0.3 0.7 0.7 -0.4 -0.6 0.2 0.6 0.9 -0.4
Allergy 8.2 19.0 32.1 3.3 5.6 5.7 -2.7 -4.1 -1.7 5.6
Pain all over the body in last month 0.4 0.4 1.3 1.1 0.5 0.3 0.3 -0.3 -0.8 0.5
Diabetes (self-reported) 0.8 1.2 2.2 -0.4 1.1 1.5 1.3 0.2 -1.4 1.1
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 3.0 0.1 -1.5 -1.7 -0.7 0.9 0.7 -1.5
Medication: Ramipril 2.5 3.3 6.9 0.7 2.6 2.3 -0.4 -1.5 -0.9 2.6
Medication: Simvastatin 2.7 4.0 8.2 1.2 2.1 2.1 -2.1 -2.9 -0.3 2.1
Fluid intelligence score 0.3 0.7 2.7 -0.6 0.1 0.4 -1.7 -1.0 -0.8 0.1
Illnesses of siblings 0.8 1.1 4.6 1.0 -0.6 -0.8 -0.8 -0.1 2.1 -0.6
Neuroticism score 0.5 1.1 3.5 -0.8 -0.8 -1.0 1.9 1.1 -0.4 -0.8
Weight 0.4 2.1 6.1 -1.0 -1.6 -1.2 -1.2 0.1 -2.5 -1.5
Impedance of arm (right) 0.2 0.9 3.9 0.6 -0.6 -0.9 0.4 -0.3 2.0 -0.6
Arm fat percentage (right) 0.1 0.5 3.2 0.3 -0.3 -0.2 -0.0 0.0 -1.8 -0.3
Trunk fat-free mass 0.6 3.4 5.8 -1.8 -2.2 -1.8 -1.5 0.4 -2.4 -2.1
Hip circumference 0.6 2.8 4.5 -2.1 -1.9 -1.7 0.6 1.2 -1.8 -1.8
Time employed in main current job 0.2 0.3 0.8 0.3 0.5 0.5 0.2 -0.1 -0.9 0.6
Alcohol intake versus 10 years previously 1.3 2.0 2.8 -0.8 -1.6 -1.2 1.6 1.4 1.7 -1.5
Father’s age at death 0.8 1.1 5.6 -2.4 -0.3 -0.3 1.0 0.4 -0.9 -0.3
Worrier / anxious feelings 0.5 0.9 2.8 -1.4 0.8 0.5 1.7 0.0 -0.5 0.8
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.4 8.8 -3.0 0.3 0.3 2.3 1.5 -0.1 0.3
Falls in the last year 0.1 0.1 0.5 0.3 0.1 -0.1 0.7 -0.1 -0.1 0.2
Hair/balding pattern: Pattern 3 0.3 0.5 0.8 0.8 0.9 0.7 -0.2 -0.2 0.9 0.8
Number of live births 2.4 3.4 11.4 -2.0 -0.8 -0.5 2.5 3.4 -0.2 -0.9
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 1.4 -1.1 -0.6 -0.8 -0.6 0.9 1.2 -0.6
Pulse rate 2.3 3.8 9.2 0.1 -3.0 -2.7 0.1 0.6 0.8 -3.0
Happiness 0.7 0.8 1.7 0.9 1.3 1.0 0.1 -0.7 -0.1 1.3
Noisy workplace 0.2 0.2 0.7 -0.0 0.5 0.4 0.0 -0.5 0.8 0.4
Qualifications: A levels/AS levels or equivalent 0.4 0.9 3.8 -0.1 0.2 0.2 -1.5 -1.9 0.1 0.2
Serious illness, injury or assault of a close relative in last 2 years 2.1 2.4 4.5 1.7 2.1 2.0 -0.8 -0.9 0.1 2.1
Mouth/teeth dental problems: Dentures 2.1 3.6 6.2 -1.9 -1.9 -1.4 1.2 2.5 2.2 -1.8
Asthma 6.8 13.3 21.0 -3.5 -4.5 -4.4 2.7 3.6 0.4 -4.6
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.0 5.1 -2.3 -1.0 -0.8 1.9 1.7 -0.2 -1.0
Medication: Cholesterol lowering 1.7 2.7 5.2 1.3 1.8 1.7 -1.6 -2.3 -0.0 1.9
Depression (self-reported) 0.1 0.1 0.2 -0.4 -0.0 -0.1 -0.4 -0.3 -0.3 -0.1
Medication: Lansoprazole 0.3 0.4 1.6 -0.9 0.2 0.1 0.3 0.0 1.2 0.2
Prospective memory result 1.1 1.3 3.4 -0.6 -1.0 -0.7 1.4 1.1 -1.8 -1.0
Lung cancer (father) 3.9 4.6 10.7 2.3 -2.1 -2.5 -1.0 0.4 3.3 -2.0
Illnesses of mother 1.0 1.3 2.6 1.6 -0.3 -0.6 -1.6 -1.4 1.1 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 2.3 -1.5 -1.0 -1.0 -0.2 1.2 0.6 -1.1
Pulse wave Arterial Stiffness index 0.8 0.9 1.5 1.1 1.2 1.2 -0.6 -0.5 -0.0 1.2
Impedance of arm (left) 0.2 0.7 2.4 -0.2 -0.6 -0.8 1.0 0.4 1.5 -0.7
Arm fat mass (right) 0.2 0.8 3.7 -0.3 -0.9 -0.6 -0.5 0.2 -1.9 -0.8
Trunk predicted mass 0.6 3.5 5.6 -1.9 -2.2 -1.8 -1.6 0.5 -2.4 -2.1
Standing height 0.5 4.6 8.6 -1.8 -2.9 -2.6 -2.2 0.2 -0.2 -2.9
Length of working week for main job 0.7 0.8 1.7 1.2 0.7 0.8 -0.6 -1.3 -0.4 0.7
Exposure to tobacco smoke at home 1.8 2.0 5.5 -1.3 -0.5 -0.7 2.4 2.4 0.7 -0.5
Breastfed as a baby 0.9 1.2 2.3 1.5 0.9 1.1 -1.3 -1.0 -0.2 0.9
Tense / ‘highly strung’ 0.3 0.4 1.1 -0.7 -0.4 -0.5 0.1 0.8 -1.0 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 3.8 -0.7 -1.8 -2.0 0.7 1.0 -0.1 -1.8
Hair/balding pattern: Pattern 4 0.4 0.9 2.7 -0.1 0.5 0.9 -1.6 -1.4 0.1 0.6
Birth weight of first child 2.0 3.5 6.2 -1.7 -2.1 -2.5 1.6 1.6 -1.0 -2.2
Peak expiratory flow (PEF) 0.0 0.1 0.4 0.2 -0.1 -0.1 -0.3 -0.0 0.6 -0.1
Pulse wave reflection index 0.7 0.9 1.5 0.3 1.2 0.9 -0.7 -1.1 -0.9 1.2
Ever highly irritable/argumentative for 2 days 1.7 2.0 2.8 -0.7 -1.6 -1.6 1.6 1.7 0.0 -1.7
Loud music exposure frequency 1.7 1.9 5.8 0.9 -0.3 -0.5 -2.4 -2.4 0.6 -0.3
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.4 -0.6 0.0 0.2 -0.0 -0.5 -0.1 -0.0
Mouth/teeth dental problems: Bleeding gums 0.7 1.0 2.0 -1.1 -0.8 -1.1 1.4 1.0 -0.2 -0.8
Blood clot in the leg (DVT) 0.5 0.6 1.4 -0.3 -0.9 -1.2 0.6 0.3 -0.9 -1.0
Medication: Paracetamol 0.7 1.1 2.3 -1.5 -0.6 -0.4 1.5 1.0 -1.2 -0.6
Headache pain in last month 0.6 1.1 1.6 -1.3 -1.2 -1.2 0.9 1.0 -0.1 -1.2
Medication for cholesterol, blood pressure or diabetes 6.8 11.2 17.8 -2.8 -4.2 -4.2 2.2 3.7 -0.1 -4.2
Glaucoma (self-reported) 0.7 0.8 1.6 0.1 1.2 1.3 0.7 -0.6 0.4 1.2
Gout (self-reported) 0.0 0.1 0.3 -0.5 -0.1 -0.1 -0.2 0.3 0.0 -0.0
Hypothyroidism/myxoedema (self-reported) 1.6 3.1 13.0 -0.3 1.2 1.3 2.0 -0.0 -3.6 1.2
Medication: Amlodipine 1.2 1.6 3.8 -0.0 1.8 2.0 -0.8 -0.7 -0.3 1.8
Medication: Ventolin 100micrograms inhaler 1.9 2.5 4.3 -1.4 -1.5 -1.4 2.1 2.0 -0.5 -1.5
Birth weight 7.0 15.1 28.3 -2.4 -5.3 -5.2 1.6 3.8 0.7 -5.3
Chronic bronchitis/emphysema (mother) 2.9 3.4 6.1 -0.9 -2.4 -2.5 0.8 1.3 1.8 -2.3
High blood pressure (siblings) 1.1 1.6 6.0 -0.3 1.0 1.1 0.3 -1.5 -2.4 0.9
Forced vital capacity (FVC), Best measure 0.4 1.6 2.5 -1.5 -1.5 -1.5 -0.3 0.9 1.0 -1.6
Body fat percentage 0.1 0.5 1.7 0.5 -0.7 -0.5 -0.3 -0.2 -1.3 -0.6
Leg fat percentage (right) 0.1 0.5 0.7 0.8 -0.8 -0.8 -0.5 -0.2 -0.7 -0.8
Arm fat-free mass (right) 0.4 2.1 5.7 -1.4 -1.4 -1.1 -1.5 0.2 -2.4 -1.4
Exposure to tobacco smoke outside home 0.2 0.2 0.4 -0.3 0.7 0.3 0.6 0.0 -0.3 0.7
Comparative body size at age 10 0.1 0.3 0.7 0.7 0.4 0.6 -0.1 -0.8 0.2 0.5
Number of full brothers 1.7 2.1 3.2 -0.9 -1.6 -1.7 1.0 1.3 -1.8 -1.6
Worry too long after embarrassment 0.2 0.3 0.8 -0.2 0.6 0.6 0.2 -0.2 -0.9 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.0 3.6 -1.9 -1.7 -1.2 -0.6 0.2 1.8 -1.7
Wheeze or whistling in the chest in last year 9.2 16.4 31.9 -2.7 -5.7 -5.3 2.1 2.8 1.8 -5.6
Number of children fathered 1.5 1.7 2.8 1.7 -1.2 -1.5 -1.4 -0.0 1.5 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 1.3 1.1 0.1 0.2 -0.6 -0.2 -0.6 0.0
Age at first live birth 2.6 4.5 9.1 2.7 1.9 1.6 -2.3 -3.0 0.3 1.9
Pulse wave peak to peak time 1.1 1.3 2.1 -1.4 -1.4 -1.4 0.6 0.7 -0.2 -1.4
Health satisfaction 0.8 1.1 2.2 -0.6 -1.5 -1.5 -0.7 0.1 0.4 -1.5
Shortness of breath walking on level ground 3.4 4.0 8.2 -2.9 -1.2 -1.1 2.7 2.7 -1.0 -1.2
Qualifications: College or University degree 2.2 6.8 16.8 1.6 2.2 2.4 -3.2 -4.1 -1.5 2.3
Eye problems/disorders: None of the above 1.2 1.4 2.5 -0.5 -1.4 -1.3 0.0 1.4 -1.6 -1.3
Mouth/teeth dental problems: Loose teeth 2.4 2.8 4.0 -1.9 -2.0 -1.6 0.6 1.7 1.8 -1.9
Emphysema/chronic bronchitis 2.0 2.3 4.5 -1.5 -2.1 -1.4 0.3 0.6 -1.6 -2.1
Medication for pain relief, constipation, heartburn 0.3 0.5 1.5 1.1 0.6 0.2 -0.6 -0.3 1.2 0.6
Neck or shoulder pain in last month 0.7 0.9 2.2 -0.4 -1.3 -1.5 0.6 0.5 -0.4 -1.3
Medication: Blood pressure 5.4 9.5 18.9 2.3 4.1 4.3 -1.1 -2.5 -0.9 4.1
Angina (self-reported) 0.2 0.3 1.1 0.7 -0.4 -0.2 -0.3 0.1 1.1 -0.5
Migraine (self-reported) 0.1 0.1 0.4 0.3 -0.1 0.1 -0.3 -0.1 0.6 -0.0
Medication: Ibuprofen 2.0 2.4 5.0 -2.2 -1.3 -1.1 1.6 2.1 0.8 -1.3
Medication: Allopurinol 0.3 0.3 0.9 -0.9 0.6 0.5 -0.0 0.6 -0.4 0.7
Medication: Omeprazole 0.8 0.9 3.0 1.0 0.3 0.4 -1.7 -1.1 -1.0 0.3
Medication: Seretide 50 evohaler 2.0 2.3 7.9 -2.2 -0.4 -0.1 2.8 1.8 -0.1 -0.4
Mean time to correctly identify matches 3.8 7.3 13.7 2.4 3.7 3.2 0.1 -2.2 -1.8 3.7
Heart disease (mother) 1.6 1.9 2.9 -1.1 1.3 1.6 1.7 0.4 -1.7 1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.0 3.3 -1.8 -0.1 -0.1 1.4 1.3 0.6 -0.0
Whole body fat mass 0.2 0.9 3.3 -0.2 -1.1 -0.8 -0.5 0.2 -1.8 -1.0
Leg fat mass (right) 0.2 0.8 2.2 0.3 -1.0 -0.8 -0.8 -0.2 -1.5 -1.0
Arm predicted mass (right) 0.5 2.5 6.4 -1.8 -1.6 -1.2 -1.1 0.5 -2.5 -1.5
Pulse rate, automated reading 3.3 10.7 23.0 -0.0 -4.8 -4.6 -1.1 0.9 2.6 -4.7
Alcohol intake frequency. 0.6 1.3 5.2 -1.1 0.5 0.5 2.3 1.4 -0.3 0.6
Comparative height size at age 10 0.8 4.5 9.4 -1.6 -3.1 -2.9 -1.1 0.8 -0.3 -3.0
Number of full sisters 0.6 0.7 1.4 -1.1 -0.6 -0.4 1.2 1.2 0.5 -0.6
Suffer from ‘nerves’ 2.9 4.5 9.6 -1.3 -1.9 -2.3 3.1 2.9 -0.2 -1.9
Overall health rating 0.6 1.4 2.1 -0.6 -1.4 -1.2 1.3 1.4 0.8 -1.3
Chest pain or discomfort 0.8 1.1 4.8 -0.1 -0.6 -1.0 2.2 0.8 0.4 -0.7
Had major operations 0.2 0.2 0.9 0.9 -0.2 0.0 -0.4 -0.5 -0.1 -0.2
Age at last live birth 0.7 1.0 2.9 1.7 1.1 0.7 -0.1 -0.7 -0.3 1.2
Family relationship satisfaction 0.3 0.4 0.9 -0.8 0.5 0.7 0.3 -1.0 0.3 0.5
Leg pain on walking 0.5 0.6 2.7 0.8 -0.2 0.1 -1.6 -0.6 -0.4 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.1 0.0 -0.1 -0.5 1.0 0.9 -1.1 -0.2
Commuting to job workplace: Car/motor vehicle 0.3 0.4 1.4 1.2 -0.1 -0.4 0.2 -0.8 -0.6 -0.2
Illness, injury, bereavement, stress in last 2 years 0.4 0.4 0.9 -0.4 -1.0 -0.6 -0.5 0.2 0.7 -0.9
Medication: Aspirin 2.8 3.7 6.2 1.9 2.0 2.3 -1.7 -2.5 -0.4 2.1
Supplements: Vitamin C 0.6 0.7 1.9 1.0 0.3 0.4 -0.9 -1.4 -1.0 0.4
Knee pain experienced in last month 0.4 0.6 1.1 -0.3 -1.1 -1.0 0.3 0.9 0.2 -1.0
Hypertension (Self-reported) 5.5 15.4 36.1 1.2 5.5 6.0 -0.8 -2.4 -2.0 5.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.6 -0.4 -0.5 -1.1 0.4 1.2 -0.1 -0.6
Illnesses of father: Heart disease 4.3 5.9 10.8 0.8 2.8 2.7 -3.3 -2.7 -0.3 2.8
Illnesses of siblings: Diabetes 0.9 1.1 3.0 -0.9 -0.6 -0.6 1.5 1.7 -0.8 -0.7
Smoking status: Previous 0.9 1.4 2.9 -0.5 1.6 1.7 0.7 0.5 -0.8 1.6
Forced expiratory volume in 1-second (FEV1), predicted 1.5 3.1 6.4 -0.5 -2.5 -2.2 -1.5 0.4 1.0 -2.5
Whole body fat-free mass 0.6 3.4 7.8 -2.0 -2.0 -1.6 -1.2 0.4 -2.8 -2.0
Leg fat-free mass (right) 0.6 3.1 11.8 -1.9 -1.5 -1.2 -0.7 0.3 -3.4 -1.4
Arm fat percentage (left) 0.2 0.7 4.2 -0.2 -0.4 -0.3 0.4 0.4 -2.0 -0.3
Average weekly red wine intake 1.9 2.8 4.7 2.2 2.0 1.5 -0.8 -1.8 -1.2 1.9
Handedness (chirality/laterality): Left-handed 0.6 0.7 2.1 -0.2 0.2 0.2 -0.7 -1.4 -1.4 0.2
Mood swings 0.1 0.2 0.5 0.4 -0.4 -0.7 0.2 0.3 0.6 -0.4
Loneliness, isolation 0.4 0.6 2.1 -1.5 0.2 0.1 0.4 0.3 -1.4 0.3
Long-standing illness, disability or infirmity 0.5 0.8 2.2 -1.5 -0.7 -0.4 0.9 -0.2 -1.1 -0.7
Ever had bowel cancer screening 4.5 5.3 9.6 1.0 2.6 3.1 -1.3 -2.4 -2.4 2.6
Diabetes diagnosed by doctor 1.4 2.4 4.7 0.3 1.8 2.2 0.6 -0.6 -2.1 1.9
Ever had stillbirth, spontaneous miscarriage or termination 2.1 2.2 7.2 0.6 -1.5 -1.5 -2.7 -1.2 0.2 -1.4
Friendships satisfaction 0.1 0.1 0.2 -0.5 0.2 -0.1 0.4 0.5 -0.2 0.2
Qualifications: nursing, teaching 0.7 1.1 4.8 0.7 -0.1 -0.1 -1.6 -2.2 0.1 -0.1
Commuting to job workplace: Walk 0.6 0.6 1.7 -0.7 0.6 1.0 -0.5 -0.7 -1.3 0.6
Eye problems/disorders: Cataract 0.8 0.9 2.6 0.7 0.7 0.4 -1.5 -1.6 0.3 0.6
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 5.1 -1.1 0.6 0.6 1.4 2.3 0.3 0.5
Medication for cholesterol 1.8 2.7 5.9 0.2 -2.0 -2.4 0.3 1.5 1.4 -2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 2.5 0.9 0.3 0.5 -1.6 -1.4 -1.2 0.3
Back pain experienced in last month 1.0 1.5 2.1 -1.5 -1.4 -1.2 0.9 1.4 0.5 -1.4
Mineral and other dietary supplements 0.4 0.6 1.2 -0.3 -0.3 -0.6 1.1 1.1 -0.9 -0.2
Breast cancer (self-reported) 0.9 1.1 2.9 -0.1 -0.1 0.2 -1.5 -1.6 -1.7 -0.0
Asthma (self-reported) 6.1 12.1 17.5 -3.4 -4.1 -4.0 2.9 3.7 0.5 -4.2
Osteoporosis (self-reported) 0.6 0.8 3.7 -0.6 0.6 0.6 -0.0 -1.9 -0.6 0.6
Osteoarthritis (self-reported) 4.5 5.8 12.0 0.0 -3.4 -3.5 1.2 2.1 0.4 -3.4
Medication: Aspirin 3.7 4.8 7.6 2.1 2.5 2.8 -1.8 -2.4 0.2 2.6
Medication: Gliclazide 2.9 3.3 7.7 0.1 2.7 2.7 0.6 -0.2 -0.3 2.8
Illnesses of father: None of the above (group 1) 2.1 2.6 5.8 -0.8 -1.6 -1.6 1.9 2.4 -0.1 -1.7
Smoking status: Current 0.7 1.2 2.5 -0.8 -1.1 -0.9 1.1 0.9 1.6 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.5 2.6 1.0 0.2 0.3 -1.6 -0.2 0.1 0.2
Whole body water mass 0.6 3.2 7.0 -1.9 -2.0 -1.6 -1.3 0.4 -2.6 -1.9
Leg predicted mass (right) 0.6 3.1 12.1 -1.9 -1.5 -1.1 -0.7 0.3 -3.5 -1.4
Arm fat mass (left) 0.2 1.0 4.5 -0.5 -1.0 -0.7 -0.2 0.4 -2.1 -0.9
Number of self-reported non-cancer illnesses 0.5 0.9 5.2 -0.3 -0.2 0.3 -0.6 -0.4 -2.3 -0.2
Average weekly champagne plus white wine intake 0.1 0.2 1.0 -0.1 0.1 -0.0 -1.0 -0.1 0.6 0.1
Miserableness 1.9 3.3 8.9 -2.4 -0.1 -0.3 2.3 1.6 -3.0 -0.2
Guilty feelings 0.2 0.3 0.8 -0.8 0.3 0.4 0.9 -0.4 0.3 0.3
Wears glasses or contact lenses 4.1 4.7 8.1 2.0 2.4 2.0 -2.3 -2.8 0.4 2.3
Ever taken oral contraceptive pill 1.4 1.6 3.3 -1.0 -1.3 -1.2 1.1 1.8 -0.2 -1.4
Hearing aid user 0.4 0.5 0.8 0.9 0.7 0.7 -0.1 0.8 0.8 0.7
Mother’s age at death 0.4 0.5 2.2 0.5 0.2 0.4 -0.7 0.4 1.5 0.3
Financial situation satisfaction 1.4 1.7 4.1 -0.3 -2.0 -1.6 0.2 0.2 -1.2 -2.0
Tinnitus: Yes, now most or all of the time 1.2 1.5 2.4 -1.1 -1.3 -1.5 -1.6 -0.8 0.5 -1.3
Commuting to job workplace: Public transport 0.4 0.5 1.3 -0.0 -1.0 -1.2 0.1 0.1 -0.2 -1.0
Eye problems/disorders: Glaucoma 0.3 0.4 1.7 0.2 0.3 0.4 0.5 -0.6 1.3 0.2
Medication: Blood pressure 5.7 10.9 24.1 1.1 4.7 4.9 -0.7 -2.6 -0.3 4.7
Pain type(s) experienced in last month: Hip pain 1.3 1.7 3.8 -1.0 -1.9 -1.9 0.1 0.2 -0.3 -1.9
Supplements: Fish oil (including cod liver oil) 0.7 0.9 2.9 -1.7 -0.7 -0.2 0.8 1.0 -0.5 -0.7
High cholesterol (Self-reported) 2.0 3.6 7.6 0.4 2.0 2.4 -1.6 -2.8 -0.4 2.1
Medication: Bendroflumethiazide 4.4 6.7 15.4 0.3 3.9 3.9 0.9 -0.5 -0.5 3.9
Medication: Paracetamol 0.8 1.2 3.0 -1.7 -0.6 -0.2 1.5 1.2 -1.0 -0.6
Medication: Lisinopril 3.5 4.5 8.5 0.7 2.9 2.9 -1.2 -2.1 -0.6 2.8
Medication: Atorvastatin 0.5 0.7 3.5 -0.3 0.6 0.5 -0.0 -0.3 -1.9 0.6
Illnesses of father: High blood pressure 1.2 1.5 2.9 -0.3 1.7 1.4 0.0 -1.1 -1.2 1.7
Alcohol drinker status: Never 0.4 0.5 1.1 -0.1 -0.9 -1.1 0.4 0.6 0.2 -1.0
Ever smoked 0.6 1.0 2.6 -1.4 0.4 0.6 1.6 1.3 0.5 0.4
Basal metabolic rate 0.6 3.4 7.3 -1.8 -2.0 -1.7 -1.3 0.4 -2.7 -2.0
Leg fat percentage (left) 0.1 0.5 1.1 1.0 -0.5 -0.5 -0.7 -0.5 -0.9 -0.5
Arm fat-free mass (left) 0.4 2.1 3.3 -1.1 -1.7 -1.4 -1.7 0.1 -1.8 -1.6
Number of operations (self-reported) 0.5 0.7 1.0 0.9 -0.9 -0.9 -1.0 -0.7 0.4 -1.0
Average weekly beer plus cider intake 0.4 0.6 1.6 0.6 -0.9 -0.8 -1.3 0.0 0.4 -0.9
Irritability 0.5 0.8 3.3 1.8 0.3 0.0 -1.0 -0.8 -0.6 0.3
Risk taking 1.0 1.4 6.2 0.7 -0.3 0.2 -2.5 -1.7 0.1 -0.3
Ever had prostate specific antigen (PSA) test 2.6 3.0 7.7 1.4 1.5 1.5 -2.1 -2.8 -0.7 1.5
Fractured/broken bones in last 5 years 2.3 2.9 5.2 1.8 -1.4 -1.9 -2.3 -1.2 1.8 -1.4
Age started oral contraceptive pill 0.2 0.3 1.0 0.8 0.2 0.2 -0.4 0.1 1.0 0.3
Diastolic blood pressure, automated reading 1.3 3.9 9.1 -1.5 2.6 3.0 -0.1 -1.1 -1.3 2.6
Ever depressed for a whole week 0.7 0.9 1.6 -0.4 -1.3 -1.1 0.9 0.6 0.7 -1.2
Unable to work because of sickness or disability 1.6 2.1 4.6 -1.1 -2.1 -1.9 -0.5 0.7 -0.0 -2.1
Commuting to job workplace: Cycle 0.4 0.5 3.1 -0.2 0.1 0.4 -1.8 -0.6 0.2 0.2
Myopia 2.5 3.6 6.4 1.1 2.4 2.5 -1.4 -2.0 -0.8 2.4
Vascular/heart problems diagnosed by doctor 4.2 11.5 26.7 -1.5 -4.7 -5.2 1.0 2.3 1.4 -4.7
Cholesterol lowering medication 0.6 0.9 3.0 0.8 -0.1 0.1 -1.7 -1.5 -0.5 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 2.3 1.0 0.1 0.1 -1.5 -0.8 -1.4 0.0
Pain experienced in last month 0.8 1.4 2.4 1.0 1.2 1.3 -1.5 -1.3 0.4 1.2
Supplements: Calcium 1.2 1.3 3.4 0.5 -1.1 -0.9 -1.4 -1.9 -0.4 -1.1
Basal cell carcinoma (self-reported) 1.5 1.8 3.0 1.2 1.2 1.1 -1.7 -1.7 1.2 1.2
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.6 0.7 -0.2 -0.5 0.1 0.5 0.8 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.9 -0.2 -0.5 -0.7 0.5 0.1 -1.0 -0.5
Heart disease (siblings) 1.1 1.3 3.1 -1.8 0.7 1.1 1.6 1.2 -0.4 0.7
Alcohol drinker status: Previous 0.3 0.3 0.8 -0.8 0.3 0.3 0.5 0.9 0.6 0.3
Pack years of smoking 1.1 1.6 5.2 2.3 0.5 0.7 -0.7 -1.7 1.1 0.6
Impedance of whole body 0.3 1.6 7.9 0.9 -0.7 -1.0 0.3 -0.1 2.8 -0.8
Leg fat mass (left) 0.2 0.7 2.7 0.3 -0.8 -0.6 -0.9 -0.3 -1.6 -0.7
Arm predicted mass (left) 0.6 2.8 4.2 -1.4 -2.1 -1.7 -1.8 0.4 -1.9 -2.0