Best TWAS P=8.2e-10 · Best GWAS P=1.44e-06 conditioned to 0.0162
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Cerebellar Hemisphere | FMNL1 | 0.27 | 0.03 | enet | 17 | 0.09 | 2.2e-03 | 4.1 | -5.6 | 2.3e-08 | -0.49 | 0.00 | 0.09 | FALSE |
2 | GTEx | Brain Cerebellum | PLEKHM1 | 0.41 | 0.44 | enet | 19 | 0.45 | 6.8e-15 | 4.8 | -5.2 | 1.6e-07 | -0.94 | 0.01 | 0.98 | FALSE |
3 | GTEx | Spleen | CRHR1 | 0.29 | 0.36 | enet | 16 | 0.34 | 1.7e-09 | 4.8 | 5.4 | 5.6e-08 | 0.91 | 0.01 | 0.98 | FALSE |
4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MAPT | 0.09 | 0.12 | lasso | 7 | 0.12 | 1.8e-13 | 6.1 | -6.1 | 1.1e-09 | -0.93 | 0.01 | 0.99 | FALSE |
5 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MAPT | 0.03 | 0.05 | lasso | 1 | 0.05 | 2.5e-06 | 6.1 | -6.1 | 9.0e-10 | -0.94 | 0.01 | 0.99 | FALSE |
6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | MAPT | 0.09 | 0.04 | blup | 84 | 0.08 | 8.7e-06 | 6.1 | -5.7 | 1.2e-08 | -0.89 | 0.02 | 0.98 | FALSE |
7 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | MAPT | 0.28 | 0.08 | blup | 81 | 0.16 | 6.2e-07 | 5.8 | -5.9 | 3.3e-09 | -0.69 | 0.02 | 0.95 | FALSE |
8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | KIAA1267 | 0.05 | 0.04 | enet | 5 | 0.06 | 1.5e-06 | 6.1 | 5.4 | 6.3e-08 | 0.89 | 0.01 | 0.99 | FALSE |
9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MAPT | 0.05 | 0.04 | lasso | 2 | 0.04 | 2.5e-05 | 6.1 | -6.1 | 8.2e-10 | -0.93 | 0.01 | 0.98 | TRUE |