Best TWAS P=1.24e-21 · Best GWAS P=2.22e-44 conditioned to 1.38e-46
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | STPG1 | 0.25 | 0.10 | enet | 23 | 0.23 | 7.6e-19 | -4.98 | -5.6 | 2.3e-08 | 0.01 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adrenal Gland | RP3-465N24.5 | 0.32 | 0.00 | enet | 25 | 0.00 | 4.1e-01 | 2.54 | 6.0 | 1.7e-09 | 0.00 | 0.12 | 0.04 | FALSE |
| 3 | GTEx | Artery Aorta | STPG1 | 0.34 | 0.12 | enet | 15 | 0.24 | 1.5e-13 | -5.56 | -5.4 | 6.2e-08 | -0.01 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Artery Coronary | RP3-465N24.5 | 0.40 | 0.03 | enet | 35 | 0.05 | 6.5e-03 | 2.54 | 5.5 | 4.9e-08 | -0.04 | 0.08 | 0.06 | FALSE |
| 5 | GTEx | Artery Tibial | RCAN3 | 0.08 | 0.02 | enet | 15 | 0.04 | 3.6e-04 | -4.79 | -7.2 | 6.7e-13 | 0.03 | 0.48 | 0.02 | TRUE |
| 6 | GTEx | Breast Mammary Tissue (Male) | RP3-465N24.5 | 0.29 | -0.01 | enet | 10 | 0.03 | 7.5e-02 | -10.40 | 9.6 | 1.2e-21 | 0.09 | 0.04 | 0.07 | TRUE |
| 7 | GTEx | Colon Transverse | RP3-465N24.5 | 0.46 | 0.01 | enet | 26 | 0.16 | 5.1e-08 | 3.95 | 5.5 | 3.3e-08 | -0.10 | 0.16 | 0.21 | FALSE |
| 8 | GTEx | Heart Left Ventricle | RP3-465N24.5 | 0.21 | 0.00 | enet | 24 | 0.06 | 2.4e-04 | 2.41 | 5.1 | 2.8e-07 | -0.07 | 0.15 | 0.09 | FALSE |
| 9 | GTEx | Lung | TMEM50A | 0.14 | 0.04 | enet | 15 | 0.00 | 1.3e-01 | 3.88 | 5.9 | 3.0e-09 | 0.00 | 0.25 | 0.12 | FALSE |
| 10 | GTEx | Skin Not Sun Exposed Suprapubic | STPG1 | 0.17 | 0.08 | enet | 5 | 0.09 | 1.3e-05 | -4.98 | -5.2 | 2.0e-07 | -0.01 | 0.90 | 0.01 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | STPG1 | 0.21 | 0.16 | lasso | 5 | 0.15 | 9.2e-13 | -4.98 | -5.3 | 8.7e-08 | 0.02 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Stomach | RP3-465N24.5 | 0.21 | 0.07 | enet | 13 | 0.04 | 3.5e-03 | 4.01 | 6.5 | 5.7e-11 | 0.03 | 0.43 | 0.04 | FALSE |
| 13 | GTEx | Thyroid | RP3-465N24.5 | 0.47 | 0.18 | enet | 24 | 0.24 | 1.7e-18 | 4.01 | 5.4 | 6.8e-08 | 0.01 | 1.00 | 0.00 | FALSE |
| 14 | METSIM | Adipose | CLIC4 | 0.05 | 0.03 | lasso | 3 | 0.04 | 3.9e-06 | 5.61 | 6.5 | 1.0e-10 | -0.08 | 0.98 | 0.00 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | TMEM50A | 0.05 | 0.00 | bslmm | 367 | 0.01 | 1.2e-02 | -0.11 | -6.2 | 6.5e-10 | -0.09 | 0.06 | 0.03 | FALSE |
| 16 | The Cancer Genome Atlas | Colon Adenocarcinoma | CLIC4 | 0.04 | 0.04 | blup | 65 | 0.02 | 1.7e-02 | 5.01 | -7.2 | 8.8e-13 | 0.04 | 0.03 | 0.51 | TRUE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GRHL3 | 0.10 | 0.02 | enet | 16 | 0.09 | 3.0e-09 | 0.88 | -5.6 | 1.7e-08 | 0.03 | 0.03 | 0.95 | FALSE |