Hub : Genes

CLIC4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells EBV-transformed lymphocytes 0.2960 0.0920 2.6e-03 -0.009 NA 0.015 NA -0.004 9.8e-01 NA 1.0e-01 NA 4.4e-01
2 METSIM Adipose 0.0472 0.0157 1.2e-04 0.033 0.024 0.034 0.031 0.036 9.7e-06 1.2e-04 7.3e-06 1.7e-05 3.9e-06
3 NTR Blood 0.0274 0.0083 1.3e-05 0.021 0.015 0.015 0.016 0.018 1.5e-07 1.1e-05 9.2e-06 4.5e-06 1.4e-06
4 TCGA Colon Adenocarcinoma 0.0380 0.0230 9.2e-03 0.039 0.023 0.001 NA 0.016 2.5e-03 1.7e-02 2.7e-01 NA 3.8e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.5 0.8 1.4 0.9 0.6 0.7 -1.2
Bipolar Disorder or Schizophrenia 0.8 1.9 6.5 2.5 0.2 0.8 -0.5
Depressed Affect (Nagel 2018) 0.1 0.2 0.3 -0.6 0.3 0.5 -0.4
Depression (Nagel 2018) 0.4 0.6 1.0 0.2 0.9 0.8 -1.0
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.7 -0.0 0.5 0.4 -0.9
Neuroticism (Nagel 2018) 0.9 2.1 3.0 -0.7 1.7 1.7 -1.4
Schizophrenia (2018) 0.6 1.3 4.9 2.2 -0.2 0.4 0.3
Schizophrenia vs Biploar Disorder 0.5 0.6 1.1 0.3 1.0 1.1 -0.5
Worry (Nagel 2018) 1.5 3.2 4.6 -0.7 2.0 2.2 -1.9
Alzheimer’s Disease (in mother) 0.3 0.4 0.7 0.8 -0.6 -0.1 0.7
Alzheimer’s Disease (in father) 1.0 1.1 2.1 0.6 1.5 1.3 -0.6
Alzheimer’s Disease (including proxy) 0.2 0.4 0.7 0.7 0.4 0.8 0.3
Crohns Disease (2017) 0.0 0.1 0.2 -0.4 -0.0 -0.3 0.4
Irritable Bowel Disease (IBD) 0.2 0.4 1.4 0.3 -1.2 -0.4 0.2
Ulcerative Colitis (UC) 0.4 0.7 1.6 1.0 -1.3 -0.3 -0.3
Major Depression (MDD) 0.7 0.8 2.7 1.6 -0.4 -0.5 -0.3
Reaction Time 0.5 0.9 1.8 -0.6 1.3 1.1 -0.6
Verbal and Numeric Reasoning (VNR) 0.6 1.3 2.4 1.0 0.8 1.5 -1.2
Breast Cancer 0.6 1.5 2.8 1.3 1.1 0.6 -1.7
Ovarian Cancer 0.4 0.5 1.2 0.8 -0.3 -1.1 0.2
Prostate Cancer 0.9 1.3 2.4 0.4 1.0 1.2 -1.6
Age at First Birth 0.6 0.8 2.1 0.3 1.5 0.6 -0.9
Bipolar Disorder (2011) 0.1 0.1 0.5 -0.1 -0.1 -0.7 0.3
Body Mass Index (BMI) (2010) 0.3 0.3 1.0 -0.2 -1.0 -0.5 0.4
Coronary Artery Disease (CAD) 2.2 2.6 5.5 -0.0 2.3 1.0 -1.9
Crohns Disease (2012) 0.2 0.3 0.7 -0.5 0.8 0.1 0.3
Mean Putamen Volume 0.4 0.5 0.9 1.0 0.5 -0.3 0.8
Fasting Glucose 0.6 0.8 1.8 1.3 1.1 0.1 0.4
HbA1C 0.7 0.8 1.8 -0.7 -1.4 -0.4 0.7
HDL Cholesterol 0.4 0.6 1.7 -1.3 0.4 -0.3 -0.6
LDL Cholesterol 0.2 0.3 0.7 0.8 -0.6 0.5 0.1
Lupus 2.1 3.1 9.4 -0.1 -0.7 -3.1 1.6
Neuroticism (2016) 0.8 1.1 1.7 0.8 0.8 1.2 -1.3
Primary Biliary Cirrhosis 0.5 0.7 1.1 0.7 -1.1 -0.4 1.1
Rheumatoid Arthritis 0.4 0.6 1.2 -0.4 -1.0 -0.3 1.1
Schizophrenia (2014) 0.7 1.5 5.5 2.4 -0.0 0.3 0.4
Triglycerides 2.7 4.4 8.3 -0.8 -2.9 -1.9 2.2
Type 2 Diabetes (T2D) (2012) 0.8 0.9 1.5 -1.2 -0.9 -0.5 0.9
Ulcerative Colitis 0.4 0.6 1.7 0.4 -1.3 -0.3 -0.4
Blood Eosinophil Count 2.2 17.1 36.5 -0.7 -6.0 -3.3 4.5
Blood Platelet Count 2.4 28.1 41.6 -2.7 -5.8 -6.5 5.4
Blood Red Count 3.1 30.1 40.6 2.7 6.2 6.4 -5.9
Blood White Count 0.0 0.3 1.0 -0.1 -0.4 -1.0 0.4
Heel T-Score 0.9 7.4 13.1 3.6 -0.4 -2.1 3.4
BMI 0.2 0.9 2.1 -1.1 -0.3 0.6 -1.5
Height 1.0 19.0 40.1 -1.8 -2.3 -6.3 5.2
Waist Hip Ratio (WHR) 0.5 2.1 6.1 -1.2 2.5 0.4 -0.9
Systolic Blood Pressure 5.1 25.6 32.7 2.1 5.7 5.7 -5.7
Smoking Status 1.2 2.8 3.9 1.8 -0.8 -1.8 2.0
Allergy or Eczema 4.9 12.8 28.3 1.6 -5.3 -3.0 3.3
Cardiovascular Disease 5.1 16.8 27.2 0.5 4.1 5.2 -4.8
Hypothyroidism (self reported) 0.1 0.2 0.8 -0.0 -0.3 0.9 -0.2
Respiratory disease 1.9 4.1 8.5 1.5 -2.9 -1.3 2.0
Type 2 Diabetes (T2D) (2018) 0.5 1.0 3.0 -0.4 0.6 0.7 -1.7
Lung FEV1/FVC ratio 1.4 7.1 15.1 -2.5 3.9 0.9 -2.5
Lung FVC 1.2 6.2 15.1 3.9 2.3 2.1 -0.6
Neuroticism 1.0 2.5 3.6 -0.7 1.7 1.7 -1.9
Chronotype (morning person) 0.2 0.4 1.1 1.0 0.5 0.3 -0.1
Hair Pigment 0.2 5.3 6.6 2.4 -1.7 -2.4 2.6
Tanning 0.2 2.5 5.4 1.6 2.3 0.3 -1.4
Hand grip strength (left) 0.2 0.6 1.6 -1.2 0.4 -0.3 -0.7
Number of treatments/medications taken 0.1 0.1 0.2 -0.2 0.4 0.3 -0.5
Average weekly spirits intake 0.1 0.1 0.3 0.0 -0.3 -0.5 0.4
Sensitivity / hurt feelings 0.2 0.4 0.9 -0.8 0.2 1.0 -0.1
Frequency of depressed mood in last 2 weeks 0.3 0.4 0.6 -0.8 0.6 0.2 -0.7
Hearing difficulty/problems: Yes 0.4 0.6 1.0 1.0 0.9 0.6 -0.3
Relative age of first facial hair 0.4 0.9 2.6 0.5 0.6 -0.6 1.6
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.3 -0.9 0.8 -1.1 0.6
Ever used hormone-replacement therapy (HRT) 0.8 1.0 1.7 1.3 1.1 0.7 -0.8
Ever had hysterectomy (womb removed) 0.4 0.4 0.8 0.8 -0.9 -0.1 0.4
Systolic blood pressure, automated reading 2.8 8.2 11.6 0.5 3.4 3.1 -3.3
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 2.8 -0.5 -0.0 1.0 -1.7
Angina 1.6 2.1 3.6 0.6 1.9 1.2 -1.7
Medication for hormone replacement therapy 0.2 0.3 0.9 0.9 -0.4 -0.1 0.2
Vitamin and mineral supplements 0.5 0.6 1.0 -1.0 0.7 0.3 -0.9
Supplements: Zinc 0.4 0.4 1.2 1.1 0.6 0.4 -0.2
Medication: Co-codamol 0.8 1.0 2.9 -1.7 -0.7 0.1 -0.7
Medication: Metformin 1.7 2.4 4.3 -0.9 1.4 1.6 -2.1
Diabetes (father) 0.2 0.2 0.4 0.6 -0.6 -0.1 0.2
Diabetes (mother) 1.6 2.1 5.9 -1.0 -0.8 -2.4 0.9
Severe depression (siblings) 0.9 1.1 1.5 -1.2 1.2 1.0 -0.5
Pack years adult smoking proportion 0.1 0.2 0.5 0.1 -0.1 0.4 -0.7
Impedance of leg (right) 1.4 6.6 14.0 1.3 2.3 3.7 -2.3
Leg fat-free mass (left) 2.1 11.3 21.1 -1.8 -3.4 -4.6 3.1
Trunk fat percentage 0.6 2.3 4.6 -1.0 -2.1 -1.3 1.4
Hand grip strength (right) 0.6 1.6 2.7 -0.9 -1.4 -1.6 1.0
Townsend deprivation index at recruitment 0.1 0.2 0.6 -0.0 -0.8 -0.3 0.0
Current tobacco smoking 0.2 0.3 0.9 -0.4 0.9 -0.4 0.2
Average weekly fortified wine intake 0.2 0.3 0.9 0.3 -0.9 -0.3 0.2
Maternal smoking around birth 1.4 2.0 2.2 -1.3 -1.4 -1.5 1.4
Fed-up feelings 0.4 0.8 1.7 -1.3 0.3 0.9 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 3.7 -1.9 1.0 0.1 -0.8
Relative age voice broke 0.3 0.5 1.0 1.0 0.7 -0.0 0.7
Taking other prescription medications 0.7 1.0 2.8 -0.4 -1.7 -0.6 0.8
Age when periods started (menarche) 0.2 0.4 1.0 0.4 0.7 -0.1 1.0
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.9 -0.9 -0.2 -0.5 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.1 4.7 0.1 -0.8 -1.7 2.2
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 1.6 -1.2 0.3 1.0 -0.6
Qualifications: CSEs or equivalent 0.7 0.9 1.9 -1.4 -0.2 -1.2 0.3
Serious illness, injury or assault to yourself 0.7 0.9 2.3 -1.5 -0.9 -0.6 0.1
High blood pressure 4.4 12.4 18.2 -0.1 3.9 4.3 -4.0
Hayfever, allergic rhinitis or eczema 6.2 13.5 27.4 1.6 -5.2 -3.3 3.6
Multivitamins +/- minerals 0.9 1.1 1.7 0.8 -1.3 -0.8 1.1
Stomach or abdominal pain in last month 1.2 1.5 4.9 -2.2 0.5 -0.7 -0.7
Supplements: Glucosamine 0.1 0.2 0.4 -0.2 0.5 0.0 -0.6
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.2 1.1 0.2 0.4 -1.0
Medication: Atenolol 4.3 5.3 8.8 1.2 3.0 1.8 -2.8
Medication: Levothyroxine sodium 0.8 1.3 2.4 -0.2 -1.4 -0.8 1.5
Sitting height 0.2 1.3 2.1 -0.9 -1.0 -1.5 1.1
Chronic bronchitis/emphysema (father) 2.5 2.9 5.2 -0.1 -2.3 -2.1 1.4
High blood pressure (mother) 0.5 0.8 1.6 0.5 0.9 1.3 -0.6
Body mass index (BMI) 0.3 1.3 2.9 -1.7 -1.3 -0.8 -0.1
Impedance of leg (left) 1.0 5.0 10.6 0.9 2.2 3.2 -1.9
Leg predicted mass (left) 2.2 11.4 21.1 -1.9 -3.3 -4.6 3.1
Trunk fat mass 1.1 4.7 7.1 -1.7 -2.7 -2.3 1.9
Waist circumference 0.5 1.7 3.6 -1.9 -1.1 -1.3 0.5
Number of incorrect matches in round 0.3 0.5 1.2 0.3 0.5 -1.1 0.8
Past tobacco smoking 1.0 1.8 4.3 1.0 0.7 1.3 -2.1
Alcohol usually taken with meals 0.7 1.1 2.9 1.7 1.0 0.4 -0.5
Nervous feelings 2.6 4.8 7.1 -1.5 2.7 2.4 -2.0
Frequency of tenseness / restlessness in last 2 weeks 1.6 2.5 9.1 -3.0 0.0 -0.8 0.6
Hearing difficulty/problems with background noise 0.9 1.5 2.9 1.7 1.0 1.4 0.2
Hair/balding pattern: Pattern 2 10.0 12.7 22.8 1.7 -4.8 -3.3 3.8
Had menopause 1.1 1.3 4.3 2.1 -0.6 -0.8 0.2
Had other major operations 0.6 0.8 1.6 0.0 -1.3 -0.5 1.1
Forced vital capacity (FVC) 0.3 1.0 3.3 0.8 1.8 0.0 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.8 5.2 0.6 -1.3 -2.0 2.3
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 2.1 -0.2 0.3 0.5 -1.5
Qualifications: None of the above 0.9 1.8 2.8 -1.7 -0.8 -1.3 1.5
Financial difficulties in last 2 years 1.4 1.8 3.9 -2.0 -1.1 -1.2 0.8
Mouth/teeth dental problems 2.6 4.0 10.4 0.3 1.1 3.2 -2.0
Heart attack 1.1 1.4 3.6 0.1 1.1 1.0 -1.9
Allergy 8.3 19.1 38.0 -1.0 6.2 4.0 -4.6
Pain all over the body in last month 3.1 3.3 7.3 0.3 -2.7 -1.7 1.8
Diabetes (self-reported) 1.0 1.5 3.3 -1.3 0.7 0.8 -1.8
Hayfever/allergic rhinitis (self-reported) 4.3 5.7 11.0 0.8 -3.3 -2.8 1.9
Medication: Ramipril 2.1 2.7 3.9 0.4 1.7 1.9 -2.0
Medication: Simvastatin 1.6 2.3 4.9 0.1 1.2 1.7 -2.2
Fluid intelligence score 1.0 2.0 3.8 0.2 0.8 2.0 -1.9
Illnesses of siblings 1.9 2.7 6.0 -0.1 -2.5 -1.1 1.9
Neuroticism score 1.1 2.3 2.7 -1.6 1.5 1.5 -1.3
Weight 1.2 5.8 9.1 -2.2 -2.4 -3.0 1.8
Impedance of arm (right) 0.6 2.7 8.2 2.9 -0.2 1.4 0.7
Arm fat percentage (right) 0.2 0.7 1.9 -0.9 -1.4 -0.1 0.1
Trunk fat-free mass 1.2 6.7 13.1 -2.5 -1.9 -3.6 1.9
Hip circumference 0.5 2.1 4.9 -1.0 -2.2 -1.3 0.9
Time employed in main current job 0.4 0.4 1.4 -0.4 0.4 0.4 -1.2
Alcohol intake versus 10 years previously 0.2 0.4 1.0 -0.1 -1.0 -0.2 0.6
Father’s age at death 0.5 0.6 2.2 -1.5 0.1 0.0 -0.6
Worrier / anxious feelings 1.3 2.4 3.7 -0.8 1.9 1.5 -1.7
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 3.2 -1.8 -0.2 0.0 -0.1
Falls in the last year 0.7 1.0 2.9 -1.7 -0.7 -0.7 0.1
Hair/balding pattern: Pattern 3 7.1 10.6 18.1 -1.9 4.3 3.1 -3.3
Number of live births 3.9 5.6 8.6 0.5 -2.9 -2.6 2.5
Forced expiratory volume in 1-second (FEV1) 0.8 2.7 8.1 -0.2 2.9 0.9 -1.3
Pulse rate 0.2 0.4 0.9 -1.0 -0.2 -0.7 -0.3
Happiness 0.1 0.1 0.2 0.1 -0.3 -0.4 0.1
Noisy workplace 1.9 2.4 4.0 -0.2 -1.6 -1.7 2.0
Qualifications: A levels/AS levels or equivalent 3.2 7.1 14.4 -0.3 3.8 2.4 -2.9
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.3 2.1 0.2 -1.5 -1.0 1.4
Mouth/teeth dental problems: Dentures 3.7 6.3 13.7 0.5 -1.9 -3.7 2.7
Asthma 3.9 7.7 12.5 2.4 -3.5 -2.2 2.8
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.5 -0.5 0.1 0.1 -0.7
Medication: Cholesterol lowering 0.3 0.4 0.8 -0.9 -0.0 0.4 -0.8
Depression (self-reported) 1.9 2.3 3.5 -1.7 0.0 1.7 -1.9
Medication: Lansoprazole 1.2 1.3 2.2 -0.4 -1.5 -1.1 1.3
Prospective memory result 0.1 0.1 0.2 0.5 0.2 -0.2 -0.1
Lung cancer (father) 0.6 0.7 2.4 -1.6 0.2 0.1 -0.6
Illnesses of mother 0.2 0.2 0.6 -0.8 0.4 -0.1 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.0 7.7 0.7 2.8 1.4 -1.4
Pulse wave Arterial Stiffness index 1.3 1.5 4.5 -2.1 -0.8 -0.7 0.7
Impedance of arm (left) 0.5 2.4 5.9 2.4 -0.8 0.1 1.8
Arm fat mass (right) 0.6 2.4 3.8 -1.7 -2.0 -1.5 0.8
Trunk predicted mass 1.2 6.7 13.2 -2.4 -2.0 -3.6 1.9
Standing height 1.4 13.5 26.1 -1.4 -2.8 -5.1 4.3
Length of working week for main job 0.3 0.4 0.7 -0.9 -0.0 -0.2 0.8
Exposure to tobacco smoke at home 0.3 0.3 0.5 0.7 -0.7 0.5 -0.4
Breastfed as a baby 0.7 0.9 1.1 -1.1 0.9 0.9 -0.8
Tense / ‘highly strung’ 0.8 1.4 2.2 -0.8 1.3 1.5 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.3 2.0 -1.4 0.2 1.1 -1.3
Hair/balding pattern: Pattern 4 12.3 29.9 51.1 -1.1 6.5 5.0 -7.2
Birth weight of first child 1.3 2.4 5.7 -0.7 0.2 1.9 -2.4
Peak expiratory flow (PEF) 2.1 4.8 7.7 0.3 2.8 2.3 -2.5
Pulse wave reflection index 0.5 0.7 2.3 -1.5 -0.6 -0.1 0.1
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.2 -0.4 0.4 -0.3 -0.2
Loud music exposure frequency 0.4 0.4 1.4 -0.4 -1.2 0.1 0.3
Qualifications: O levels/GCSEs or equivalent 2.4 3.9 5.1 -1.9 2.3 1.4 -2.2
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 2.1 -0.6 -0.4 -1.5 0.4
Blood clot in the leg (DVT) 1.5 1.9 3.2 -0.6 -1.8 -1.4 1.5
Medication: Paracetamol 0.3 0.5 0.7 -0.8 -0.7 -0.6 0.8
Headache pain in last month 0.4 0.7 2.3 0.3 1.5 0.4 -0.3
Medication for cholesterol, blood pressure or diabetes 1.5 2.5 5.3 0.4 -1.0 -1.9 2.3
Glaucoma (self-reported) 0.6 0.7 1.6 0.3 -1.1 -0.3 1.2
Gout (self-reported) 0.5 0.6 1.6 0.9 0.1 1.2 -0.3
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.4 -0.5 -1.2 0.7 0.7
Medication: Amlodipine 1.7 2.4 3.9 0.6 1.8 2.0 -1.5
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.0 -0.2 -1.0 -0.7 0.8
Birth weight 1.3 2.9 4.3 -0.9 -2.1 -2.0 1.6
Chronic bronchitis/emphysema (mother) 1.0 1.2 2.8 0.2 -1.7 -1.3 0.6
High blood pressure (siblings) 0.2 0.3 0.9 -0.4 1.0 0.1 -0.4
Forced vital capacity (FVC), Best measure 0.4 1.5 3.0 1.5 1.7 0.7 -0.3
Body fat percentage 0.3 1.2 2.9 -1.2 -1.7 -0.5 0.6
Leg fat percentage (right) 0.2 0.7 1.3 -1.1 -0.6 0.7 -0.9
Arm fat-free mass (right) 1.4 7.1 13.8 -2.7 -2.0 -3.7 1.8
Exposure to tobacco smoke outside home 0.5 0.6 1.4 0.9 0.5 1.2 -0.5
Comparative body size at age 10 0.2 0.4 1.0 0.4 -0.7 -1.0 0.4
Number of full brothers 0.3 0.4 0.6 0.7 -0.5 -0.5 0.7
Worry too long after embarrassment 0.1 0.2 0.6 -0.3 0.8 0.4 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 1.4 -1.2 0.5 0.7 -0.7
Wheeze or whistling in the chest in last year 2.4 4.3 8.2 0.7 -2.9 -2.1 1.9
Number of children fathered 0.5 0.5 1.9 -0.4 -0.2 -0.4 1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.1 0.2 0.1 -0.4 0.0 0.2
Age at first live birth 1.8 3.2 6.2 0.1 1.8 2.5 -1.9
Pulse wave peak to peak time 0.9 1.0 4.1 2.0 0.2 0.1 -0.1
Health satisfaction 1.3 1.7 3.6 -1.7 -0.2 -1.9 0.4
Shortness of breath walking on level ground 0.7 0.8 2.6 -1.6 0.3 -0.6 -0.2
Qualifications: College or University degree 0.8 2.5 7.6 2.8 1.2 0.8 -0.7
Eye problems/disorders: None of the above 0.4 0.4 0.9 -0.9 -0.0 -0.9 0.3
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.4 -1.2 0.8 -0.5 0.7
Emphysema/chronic bronchitis 0.2 0.2 0.5 -0.3 -0.2 -0.2 0.7
Medication for pain relief, constipation, heartburn 0.5 0.8 3.0 1.7 -0.3 0.2 0.4
Neck or shoulder pain in last month 0.4 0.6 1.3 -1.1 -0.7 -0.5 0.5
Medication: Blood pressure 3.1 5.6 10.4 -0.1 1.9 2.9 -3.2
Angina (self-reported) 1.7 2.3 3.4 0.8 1.8 1.2 -1.8
Migraine (self-reported) 0.1 0.1 0.3 -0.5 -0.3 0.3 0.0
Medication: Ibuprofen 0.4 0.4 0.8 -0.4 0.8 0.4 -0.9
Medication: Allopurinol 0.1 0.2 0.4 -0.3 -0.6 0.3 0.4
Medication: Omeprazole 2.7 3.2 9.9 -3.1 -1.4 -0.9 0.3
Medication: Seretide 50 evohaler 1.5 1.7 3.4 0.3 -1.5 -1.8 1.0
Mean time to correctly identify matches 0.5 1.0 1.8 0.6 1.4 1.4 -0.4
Heart disease (mother) 0.2 0.3 0.5 0.7 -0.5 0.3 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.8 0.4 -0.4 0.9 -0.3
Whole body fat mass 0.7 3.1 4.5 -1.9 -2.1 -1.7 1.1
Leg fat mass (right) 0.5 2.0 3.8 -1.9 -1.6 -1.1 0.4
Arm predicted mass (right) 1.6 8.0 16.6 -2.6 -2.0 -4.1 2.1
Pulse rate, automated reading 0.3 0.9 1.8 -1.4 -0.9 -1.0 -0.3
Alcohol intake frequency. 0.1 0.3 0.7 0.8 0.1 0.8 -0.2
Comparative height size at age 10 1.7 9.2 15.9 0.5 -3.2 -4.0 3.2
Number of full sisters 1.8 2.2 3.8 -1.9 -1.7 -1.1 1.0
Suffer from ‘nerves’ 1.0 1.6 2.3 -1.5 1.2 1.1 -1.2
Overall health rating 0.3 0.6 1.3 -1.1 -0.5 -1.0 -0.3
Chest pain or discomfort 0.4 0.6 1.4 0.2 1.0 0.3 -1.2
Had major operations 0.2 0.3 0.8 -0.5 -0.2 0.2 -0.9
Age at last live birth 0.5 0.7 1.3 0.2 -0.0 1.1 -1.2
Family relationship satisfaction 0.1 0.1 0.2 -0.4 0.4 0.0 0.5
Leg pain on walking 1.0 1.3 2.4 -0.5 -0.8 -1.6 1.3
Qualifications: NVQ or HND or HNC or equivalent 1.7 2.0 3.1 -0.3 -1.7 -1.4 1.8
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.8 -0.3 0.0 -0.9 0.5
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.3 0.6 1.1 0.5 -0.3
Medication: Aspirin 1.9 2.5 5.8 -0.6 2.4 1.4 -1.5
Supplements: Vitamin C 0.4 0.4 1.1 0.1 1.0 0.8 -0.2
Knee pain experienced in last month 1.7 2.6 4.9 -1.4 -2.2 -1.7 1.0
Hypertension (Self-reported) 5.0 13.9 19.5 -0.2 4.2 4.4 -4.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.3 2.7 3.7 -1.1 -1.7 -1.9 1.8
Illnesses of father: Heart disease 3.5 4.8 6.7 1.8 1.9 2.4 -2.6
Illnesses of siblings: Diabetes 0.3 0.4 0.9 0.0 0.7 0.2 -1.0
Smoking status: Previous 1.9 2.8 6.0 -0.4 -1.8 -1.4 2.5
Forced expiratory volume in 1-second (FEV1), predicted 3.4 7.2 11.9 -1.5 -2.4 -3.0 3.5
Whole body fat-free mass 1.5 8.8 17.3 -2.5 -2.5 -4.2 2.4
Leg fat-free mass (right) 2.5 13.6 25.4 -2.1 -3.5 -5.0 3.5
Arm fat percentage (left) 0.4 1.6 3.8 -1.0 -1.9 -0.9 0.8
Average weekly red wine intake 0.6 0.8 1.2 1.0 -1.1 -0.7 0.7
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.3 -0.2 0.3 0.6 -0.5
Mood swings 0.1 0.2 0.4 -0.6 -0.5 0.1 0.1
Loneliness, isolation 0.3 0.4 0.9 -1.0 0.5 0.6 -0.1
Long-standing illness, disability or infirmity 0.4 0.6 1.1 -1.1 -0.3 -1.1 -0.1
Ever had bowel cancer screening 2.9 3.4 7.6 -0.6 -1.2 -2.8 2.1
Diabetes diagnosed by doctor 2.4 4.0 8.4 -1.2 1.8 1.7 -2.9
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.4 -0.4 -0.7 -0.0 -0.4
Friendships satisfaction 1.9 2.4 7.2 2.7 0.0 -0.7 1.3
Qualifications: nursing, teaching 1.2 1.9 2.6 -0.7 1.6 1.5 -1.5
Commuting to job workplace: Walk 0.4 0.5 1.6 -0.3 -0.3 1.3 -0.4
Eye problems/disorders: Cataract 0.3 0.4 1.5 1.2 -0.2 0.1 0.2
Mouth/teeth dental problems: Mouth ulcers 1.7 2.6 10.4 -3.2 0.2 0.2 -0.3
Medication for cholesterol 1.5 2.3 3.9 -1.8 -2.0 -1.1 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 2.9 0.7 0.8 1.7 -1.1
Back pain experienced in last month 0.5 0.7 2.7 -1.6 0.1 -0.3 0.2
Mineral and other dietary supplements 0.3 0.4 0.9 -0.2 0.2 0.8 -1.0
Breast cancer (self-reported) 4.7 5.6 10.4 -0.0 -3.2 -2.7 2.2
Asthma (self-reported) 4.1 8.2 13.3 2.4 -3.6 -2.3 2.9
Osteoporosis (self-reported) 1.1 1.4 4.1 2.0 0.4 0.8 -0.7
Osteoarthritis (self-reported) 0.3 0.4 0.5 0.5 -0.5 -0.7 0.6
Medication: Aspirin 1.0 1.3 2.9 -0.3 1.7 1.0 -1.1
Medication: Gliclazide 0.1 0.1 0.2 -0.5 0.5 0.1 -0.1
Illnesses of father: None of the above (group 1) 0.3 0.4 1.3 -1.2 -0.3 -0.1 -0.0
Smoking status: Current 0.3 0.5 0.8 -0.4 0.7 -0.9 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.8 3.7 6.9 0.8 2.6 2.3 -1.5
Whole body water mass 1.5 8.6 16.6 -2.5 -2.4 -4.1 2.4
Leg predicted mass (right) 2.5 13.6 25.4 -2.1 -3.5 -5.0 3.5
Arm fat mass (left) 0.8 3.1 4.8 -1.6 -2.2 -1.9 1.2
Number of self-reported non-cancer illnesses 0.4 0.8 1.8 -0.6 -1.4 -0.4 0.8
Average weekly champagne plus white wine intake 0.3 0.5 1.1 0.8 1.1 0.1 -0.3
Miserableness 0.4 0.7 2.4 -1.6 0.2 0.6 -0.2
Guilty feelings 1.0 1.6 3.0 -0.7 1.7 1.4 -0.9
Wears glasses or contact lenses 0.7 0.8 1.6 -0.9 -0.7 -0.7 1.2
Ever taken oral contraceptive pill 0.5 0.6 1.5 -0.6 0.1 0.6 -1.2
Hearing aid user 2.5 2.8 5.4 2.3 -0.8 -1.6 1.6
Mother’s age at death 0.4 0.5 1.3 -0.3 -0.5 -1.1 -0.5
Financial situation satisfaction 0.1 0.2 0.2 0.2 0.5 -0.4 0.4
Tinnitus: Yes, now most or all of the time 2.4 2.8 4.2 0.9 -1.6 -2.0 1.9
Commuting to job workplace: Public transport 2.5 3.0 4.6 0.3 1.8 2.0 -2.1
Eye problems/disorders: Glaucoma 0.6 0.7 1.4 -0.4 -1.2 -0.6 0.8
Medication: Blood pressure 4.4 8.3 12.8 1.0 3.6 3.2 -3.0
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.2 -0.3 -0.4 -1.1 -0.1
Supplements: Fish oil (including cod liver oil) 0.2 0.3 1.1 1.0 0.3 0.2 -0.2
High cholesterol (Self-reported) 0.0 0.1 0.1 0.1 -0.2 0.4 0.1
Medication: Bendroflumethiazide 3.5 5.4 8.1 0.2 2.7 2.4 -2.8
Medication: Paracetamol 0.5 0.8 2.7 -1.6 -0.3 -0.2 0.7
Medication: Lisinopril 1.8 2.3 5.5 -0.2 2.4 1.1 -1.6
Medication: Atorvastatin 0.1 0.1 0.5 0.1 0.7 0.1 0.0
Illnesses of father: High blood pressure 3.1 3.9 7.6 -0.7 2.8 2.2 -1.6
Alcohol drinker status: Never 1.6 1.9 3.7 -0.4 1.0 1.6 -1.9
Ever smoked 0.2 0.3 0.4 -0.6 0.6 -0.1 0.6
Basal metabolic rate 1.5 8.5 15.7 -2.5 -2.6 -4.0 2.3
Leg fat percentage (left) 0.2 0.9 2.5 -1.6 -0.6 0.3 -0.6
Arm fat-free mass (left) 1.1 5.3 9.8 -2.7 -1.6 -3.1 1.3
Number of operations (self-reported) 0.9 1.3 2.5 -0.5 -1.6 -1.3 0.9
Average weekly beer plus cider intake 0.2 0.3 0.6 0.5 -0.3 0.8 -0.7
Irritability 1.1 1.9 3.4 -1.5 1.8 0.5 -1.3
Risk taking 0.4 0.6 0.8 -0.6 -0.5 -0.9 0.9
Ever had prostate specific antigen (PSA) test 0.6 0.7 2.0 0.3 -1.4 -0.8 0.4
Fractured/broken bones in last 5 years 0.5 0.7 2.4 1.5 -0.7 -0.1 0.2
Age started oral contraceptive pill 0.9 1.1 3.1 0.8 1.8 0.3 -0.8
Diastolic blood pressure, automated reading 5.1 15.9 22.2 0.5 4.5 4.5 -4.7
Ever depressed for a whole week 0.2 0.2 0.7 -0.8 -0.2 -0.2 0.3
Unable to work because of sickness or disability 0.4 0.6 2.2 0.1 -1.5 -0.3 0.1
Commuting to job workplace: Cycle 1.6 1.9 4.5 2.1 0.3 0.8 -1.6
Myopia 0.4 0.5 1.1 -1.1 -0.2 -0.2 1.0
Vascular/heart problems diagnosed by doctor 4.0 10.8 14.7 -0.1 -3.7 -3.8 3.8
Cholesterol lowering medication 2.0 2.9 4.1 1.9 2.0 1.6 -1.3
Medication: Omeprazole (e.g. Zanprol) 2.1 2.5 6.5 -2.6 -1.5 -1.0 0.6
Pain experienced in last month 1.0 1.7 2.7 1.1 0.8 1.7 -1.5
Supplements: Calcium 0.6 0.6 1.3 -0.0 -1.1 -0.5 1.1
Basal cell carcinoma (self-reported) 0.4 0.5 1.4 0.2 0.2 0.7 -1.2
Heart attack/myocardial infarction (self-reported) 1.2 1.5 3.7 0.1 1.1 1.0 -1.9
Deep venous thrombosis (DVT) (self-reported) 0.9 1.1 2.2 -0.1 -1.5 -1.0 1.1
Heart disease (siblings) 1.4 1.7 3.1 1.8 1.6 0.8 -0.7
Alcohol drinker status: Previous 0.2 0.2 0.6 0.8 -0.3 -0.1 0.1
Pack years of smoking 0.1 0.1 0.3 0.3 -0.2 0.1 -0.5
Impedance of whole body 0.4 2.1 4.7 2.2 0.6 1.8 0.1
Leg fat mass (left) 0.6 2.5 5.4 -2.3 -1.6 -1.3 0.6
Arm predicted mass (left) 0.9 4.8 8.9 -2.5 -1.5 -3.0 1.2