Hub : Genes

RCAN3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0764	0.0323	0.0060	0.016	NA	0.041	NA	0.021	0.0190	NA	0.00036	NA	0.0081
2	GTEx	Nerve Tibial	0.1100	0.0417	0.0061	0.002	NA	0.001	NA	0.010	0.2400	NA	0.26000	NA	0.0580
3	GTEx	Skin Sun Exposed Lower leg	0.1620	0.0650	0.0090	0.010	NA	0.017	NA	0.015	0.0450	NA	0.01400	NA	0.0190
4	ROSMAP	Brain Pre-frontal Cortex	0.0487	0.0226	0.0170	-0.001	0.003	0.007	0.005	0.007	0.4200	0.11000	0.03700	0.075	0.0360
5	TCGA	Liver Hepatocellular Carcinoma	0.0760	0.0440	0.0064	0.055	0.062	0.030	NA	0.055	0.0014	0.00071	0.01400	NA	0.0014
6	TCGA	Pancreatic Adenocarcinoma	0.1130	0.0600	0.0067	0.001	0.039	0.033	NA	0.041	0.2700	0.00980	0.01600	NA	0.0077
7	TCGA	Rectum Adenocarcinoma	0.1670	0.0810	0.0096	0.098	-0.004	0.027	NA	-0.008	0.0027	0.42000	0.07800	NA	0.5300

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.1	0.1	0.2	-0.2	0.2	0.3	0.0	0.4	-0.2	-0.5
Bipolar Disorder or Schizophrenia	0.8	1.9	6.3	1.8	0.5	0.3	0.8	-0.7	-1.6	-2.5
Depressed Affect (Nagel 2018)	0.4	0.9	2.7	-0.2	0.3	-1.0	-0.2	1.2	1.1	1.6
Depression (Nagel 2018)	0.2	0.2	0.7	-0.4	-0.2	0.1	-0.3	0.8	0.8	0.2
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.6	-0.9	-0.3	0.3	-1.6	-0.0	-1.0	-0.2
Neuroticism (Nagel 2018)	0.2	0.5	1.3	-0.7	-0.4	-0.7	-0.3	0.5	0.8	1.1
Schizophrenia (2018)	1.5	3.0	8.1	2.6	0.5	0.3	1.0	-1.2	-1.9	-2.9
Schizophrenia vs Biploar Disorder	0.6	0.8	1.5	0.6	1.2	-1.2	-0.9	-0.8	-0.3	-1.1
Worry (Nagel 2018)	0.2	0.5	1.2	-1.0	-0.3	-1.1	-0.5	-0.2	0.6	0.5
Alzheimer’s Disease (in mother)	0.3	0.4	2.0	-0.0	-0.3	-0.1	-0.4	0.6	1.4	0.3
Alzheimer’s Disease (in father)	1.7	1.9	7.8	-0.1	-1.7	0.6	-2.8	1.1	0.8	0.3
Alzheimer’s Disease (including proxy)	1.0	1.5	6.1	0.3	-0.9	0.3	-2.5	0.7	1.6	0.5
Crohns Disease (2017)	1.5	3.3	6.2	2.1	-1.6	-1.3	1.1	-1.6	-2.1	-2.5
Irritable Bowel Disease (IBD)	0.9	2.1	2.8	1.3	-1.6	-1.4	1.3	-1.0	-1.7	-1.6
Ulcerative Colitis (UC)	0.3	0.6	1.6	0.1	-1.3	-0.6	1.2	-0.0	-0.7	-0.1
Major Depression (MDD)	0.2	0.2	0.6	0.5	0.1	-0.2	0.8	-0.4	-0.2	-0.5
Reaction Time	0.4	0.9	2.8	0.6	0.1	-1.5	1.7	0.2	-0.7	-0.2
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.7	0.8	-0.2	-0.7	-1.3	-0.8	-1.2	-1.2
Breast Cancer	0.8	1.9	4.8	-0.7	1.3	2.2	-0.8	1.3	-0.5	1.9
Ovarian Cancer	0.3	0.4	1.6	-0.3	-0.8	-0.2	-1.3	0.2	0.5	0.4
Prostate Cancer	4.1	5.8	12.3	-3.3	-3.5	-0.8	-1.2	2.5	1.5	2.5
Age at First Birth	0.3	0.4	1.7	0.9	-0.5	0.2	1.3	0.2	-0.1	-0.2
Bipolar Disorder (2011)	0.1	0.1	0.2	0.0	0.0	0.5	-0.4	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.8	1.2	2.4	1.5	0.7	-1.1	-0.5	-1.2	-1.3	-0.6
Coronary Artery Disease (CAD)	0.2	0.3	0.9	-0.5	-0.1	0.6	-0.0	0.1	0.6	1.0
Crohns Disease (2012)	1.3	2.2	4.9	1.2	-2.2	-1.0	1.2	-0.7	-1.3	-2.1
Mean Putamen Volume	0.2	0.2	0.8	-0.1	0.0	0.4	-0.2	0.9	0.1	0.6
Fasting Glucose	0.8	0.9	2.1	-1.4	1.2	0.9	0.5	1.1	0.8	0.0
HbA1C	1.5	1.7	5.1	-1.5	-0.5	-2.3	1.7	-0.4	-0.9	-0.5
HDL Cholesterol	0.6	1.0	2.6	-1.5	-1.6	0.6	-0.2	1.1	-0.1	0.8
LDL Cholesterol	0.6	0.9	2.3	-1.3	0.4	-0.0	0.4	1.2	1.5	0.4
Lupus	1.9	2.9	8.9	2.0	-0.4	1.1	-0.9	-3.0	-1.6	-1.6
Neuroticism (2016)	1.0	1.4	5.0	0.6	-0.0	0.8	-1.6	-1.1	0.0	-2.2
Primary Biliary Cirrhosis	0.9	1.2	3.0	-1.7	-1.6	-0.7	0.7	0.3	1.3	-0.4
Rheumatoid Arthritis	0.5	0.7	1.3	0.0	-1.1	-0.8	0.6	-0.8	-1.0	-1.2
Schizophrenia (2014)	1.3	2.8	9.9	1.9	1.2	-0.8	0.8	-1.1	-1.6	-3.2
Triglycerides	0.3	0.5	1.3	0.1	0.9	-0.4	1.1	-1.1	0.3	-0.0
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.8	0.7	-1.1	-1.0	-1.3	-0.4	-0.6	0.6
Ulcerative Colitis	0.4	0.6	1.5	1.1	-0.4	-1.2	0.7	-0.6	-0.4	-0.3
Blood Eosinophil Count	0.3	2.1	4.5	-0.3	2.1	1.4	2.1	0.8	1.2	1.3
Blood Platelet Count	0.4	4.9	11.8	1.2	-1.4	-0.6	3.1	-3.4	-2.4	-1.7
Blood Red Count	0.4	3.6	6.2	-1.4	2.5	0.4	-2.0	2.4	1.9	1.8
Blood White Count	0.2	1.8	5.8	-1.0	1.5	2.4	1.5	0.4	0.9	0.5
Heel T-Score	0.4	3.0	5.1	-1.7	-1.4	2.0	-0.3	2.0	1.7	2.2
BMI	0.3	1.5	5.3	-0.1	2.3	0.9	2.0	-0.0	-0.3	-0.3
Height	0.1	2.3	7.5	0.4	-2.7	-2.1	0.6	-0.2	-1.5	-1.1
Waist Hip Ratio (WHR)	0.6	2.7	6.7	-2.6	-0.5	-0.4	-0.5	1.8	2.0	2.2
Systolic Blood Pressure	0.3	1.7	3.7	-1.6	1.5	-1.9	0.8	1.2	0.8	0.6
Smoking Status	0.8	2.0	3.9	-0.9	1.3	1.1	0.2	1.8	2.0	1.7
Allergy or Eczema	0.5	1.2	4.9	0.4	-1.1	-2.2	0.7	0.5	0.6	-1.1
Cardiovascular Disease	0.7	2.2	5.2	-1.8	1.1	-1.9	0.4	1.4	2.3	0.4
Hypothyroidism (self reported)	4.4	10.0	18.2	3.0	2.2	-2.0	4.2	-3.5	-2.1	-4.3
Respiratory disease	1.2	2.8	5.6	1.1	-1.0	-1.9	1.4	-2.1	-1.2	-2.4
Type 2 Diabetes (T2D) (2018)	0.8	1.4	7.7	-0.5	0.8	-0.5	2.8	-0.4	0.5	-0.8
Lung FEV1/FVC ratio	0.1	0.7	2.8	-1.7	0.7	0.2	-0.7	-0.8	0.1	0.2
Lung FVC	1.7	8.6	24.3	-4.9	-1.6	0.3	-3.0	3.4	3.4	0.9
Neuroticism	0.2	0.5	1.0	-0.5	0.4	0.5	0.9	1.0	0.6	0.5
Chronotype (morning person)	0.2	0.4	1.5	0.2	-0.1	-0.3	0.1	-0.9	-0.6	-1.2
Hair Pigment	0.7	20.6	44.5	6.7	0.6	-3.0	3.4	-5.6	-4.7	-5.1
Tanning	0.4	4.6	8.3	-2.5	-2.9	2.2	-1.9	1.7	1.8	1.7
Hand grip strength (left)	0.5	1.3	3.5	1.3	0.4	0.7	1.1	-1.1	-1.9	-0.7
Number of treatments/medications taken	0.7	1.2	3.5	-1.3	-1.0	-1.0	0.3	0.4	1.9	0.9
Average weekly spirits intake	0.8	1.0	3.4	-0.8	-0.7	0.7	1.9	1.1	0.8	0.3
Sensitivity / hurt feelings	0.1	0.2	1.3	0.4	1.1	-0.4	-0.2	0.2	-0.2	0.1
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.0	-0.4	-1.2	1.4	-0.9	1.1	1.2	0.8
Hearing difficulty/problems: Yes	0.3	0.5	1.4	0.7	-0.4	1.2	0.6	-0.4	0.9	-0.3
Relative age of first facial hair	0.3	0.7	3.9	0.2	0.6	0.4	2.0	0.6	0.1	-0.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	2.2	-0.6	-0.2	1.5	-0.0	-0.6	0.7	0.0
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.3	-1.1	-0.8	0.3	0.5	0.8	1.1	0.0
Ever had hysterectomy (womb removed)	0.8	0.9	2.6	1.6	0.8	-0.2	-1.6	-0.8	-0.4	0.1
Systolic blood pressure, automated reading	0.4	1.1	2.6	-1.2	-0.3	-1.6	0.5	1.2	-0.0	1.4
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	4.7	-1.5	-2.2	-1.7	-0.1	-0.5	0.1	0.7
Angina	2.2	2.9	7.1	-2.3	0.7	0.4	-0.3	2.1	2.7	1.5
Medication for hormone replacement therapy	2.0	2.2	4.8	-2.0	-2.2	1.3	0.6	1.3	1.7	0.7
Vitamin and mineral supplements	1.1	1.4	4.0	-2.0	-0.0	1.4	-0.6	0.1	1.9	0.3
Supplements: Zinc	1.0	1.1	3.9	0.0	0.3	2.0	-0.2	0.6	1.3	1.3
Medication: Co-codamol	1.1	1.3	3.5	0.4	0.9	1.6	0.3	0.5	1.4	1.9
Medication: Metformin	1.2	1.6	4.4	-2.1	1.0	0.1	2.0	0.6	1.0	0.8
Diabetes (father)	0.8	1.0	4.6	-0.8	0.0	-0.1	-0.2	0.6	2.1	1.1
Diabetes (mother)	0.9	1.2	2.2	-1.4	-1.2	1.2	1.5	0.1	1.2	0.2
Severe depression (siblings)	0.7	0.8	3.3	0.2	1.8	-0.5	0.1	-0.4	-1.2	-0.6
Pack years adult smoking proportion	0.2	0.3	0.7	-0.5	0.1	0.5	-0.3	0.2	0.7	0.8
Impedance of leg (right)	0.8	3.9	13.0	-1.6	0.4	-0.1	-3.6	2.0	2.5	1.2
Leg fat-free mass (left)	0.7	4.0	7.8	1.8	0.7	-0.2	2.8	-2.3	-2.2	-2.5
Trunk fat percentage	0.3	1.4	4.7	-1.1	2.2	0.1	0.9	1.2	1.2	0.4
Hand grip strength (right)	0.6	1.5	2.9	1.4	0.2	0.7	1.5	-1.2	-1.7	-1.3
Townsend deprivation index at recruitment	0.4	0.6	2.1	0.1	0.5	-0.5	-0.7	0.9	0.3	1.5
Current tobacco smoking	0.7	1.2	2.4	-1.2	1.1	1.6	-0.5	0.9	0.9	1.1
Average weekly fortified wine intake	0.8	0.9	2.9	-0.4	-1.7	0.1	-0.3	0.6	1.7	0.2
Maternal smoking around birth	0.3	0.4	1.3	-0.6	-1.1	-0.1	-0.8	-0.6	-0.6	0.1
Fed-up feelings	0.2	0.3	1.4	-0.5	-1.2	0.2	-0.2	-0.0	0.5	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.9	-0.5	-0.5	0.0	-0.2	-0.8	-0.9	-0.7
Relative age voice broke	0.2	0.3	0.8	0.9	-0.6	-0.9	0.1	-0.1	-0.3	-0.6
Taking other prescription medications	0.3	0.5	1.2	0.2	-1.1	-0.6	0.8	-0.9	-0.6	-0.3
Age when periods started (menarche)	0.3	0.7	1.2	0.8	0.0	0.8	0.7	-0.9	-0.9	-1.1
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.1	-0.6	-1.1	-0.4	-0.6	0.0	1.0	0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.6	9.1	-2.4	-0.3	1.1	-1.2	2.2	1.6	3.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	1.4	0.1	1.2	0.6	0.0	0.4	0.1	0.7
Qualifications: CSEs or equivalent	0.4	0.5	0.9	-0.9	-0.5	0.7	0.4	0.7	0.6	0.7
Serious illness, injury or assault to yourself	0.4	0.5	1.2	-0.2	0.1	0.7	1.0	-1.1	-0.8	-0.3
High blood pressure	0.7	1.8	4.9	-1.8	0.2	-2.2	1.2	0.9	1.6	0.2
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.7	0.8	-1.4	-1.4	0.7	-0.3	0.1	-1.6
Multivitamins +/- minerals	0.4	0.6	2.0	1.4	-0.5	-0.0	0.7	-0.2	-1.0	-0.4
Stomach or abdominal pain in last month	1.5	1.9	3.7	-1.7	-0.8	0.9	-1.2	0.7	1.8	1.9
Supplements: Glucosamine	0.7	1.0	2.0	-1.4	-0.0	1.0	-0.5	1.3	0.8	1.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.4	-1.2	0.3	-0.8	-0.8	0.8	1.2	0.4
Medication: Atenolol	0.5	0.6	2.0	-0.6	0.6	1.4	0.8	0.5	0.6	-0.5
Medication: Levothyroxine sodium	1.8	3.0	13.9	0.2	0.8	-1.7	3.7	-0.8	-0.5	-1.6
Sitting height	0.1	0.7	2.0	-0.3	0.3	-0.9	1.0	-0.0	-0.8	-1.4
Chronic bronchitis/emphysema (father)	0.4	0.4	1.3	-0.4	-0.3	0.5	1.1	-0.1	-0.9	-0.7
High blood pressure (mother)	0.2	0.3	0.7	-0.5	0.6	-0.8	0.2	-0.2	0.8	-0.5
Body mass index (BMI)	0.3	1.3	5.4	-0.5	1.7	0.4	2.3	-0.3	0.1	-0.2
Impedance of leg (left)	0.8	4.1	10.7	-2.0	0.4	-0.2	-3.3	2.4	2.2	1.8
Leg predicted mass (left)	0.8	4.0	8.1	1.8	0.7	-0.3	2.8	-2.3	-2.2	-2.5
Trunk fat mass	0.2	0.9	3.5	-0.6	1.9	-0.1	1.5	0.2	0.4	-0.3
Waist circumference	0.2	0.7	2.9	-1.1	0.4	0.0	1.7	-0.6	-0.1	-0.3
Number of incorrect matches in round	0.6	1.0	2.1	0.3	1.1	1.0	1.3	-0.9	-0.1	-1.5
Past tobacco smoking	0.3	0.5	1.8	0.8	-0.1	0.9	0.1	-0.5	-0.5	-1.3
Alcohol usually taken with meals	1.6	2.7	9.7	-0.9	-1.0	1.4	-3.1	1.7	1.1	1.0
Nervous feelings	0.3	0.5	2.6	-1.6	-0.7	-0.2	-0.6	-0.1	-0.1	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	4.2	-0.2	-0.9	0.6	-1.2	-0.5	-2.0	0.8
Hearing difficulty/problems with background noise	0.2	0.4	1.5	0.7	-1.2	-0.0	0.5	-0.3	0.5	-0.1
Hair/balding pattern: Pattern 2	2.4	3.1	8.9	3.0	0.5	2.1	0.5	-1.9	-0.8	-2.0
Had menopause	0.5	0.7	1.3	-0.0	-1.2	-1.0	1.0	-0.4	-0.5	-0.9
Had other major operations	0.7	0.8	3.0	1.7	-0.1	-0.8	1.1	-0.3	0.8	-0.1
Forced vital capacity (FVC)	0.4	1.6	4.1	-1.5	-2.0	-0.6	-1.8	0.1	0.4	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	10.4	-2.9	-0.0	1.0	-1.1	2.6	1.5	3.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	-0.3	0.5	-0.2	0.0	-0.4	-0.1	0.5
Qualifications: None of the above	0.9	2.0	7.3	-1.7	-0.0	-1.6	2.7	-0.3	1.0	0.3
Financial difficulties in last 2 years	1.2	1.6	4.4	-1.6	-1.3	0.2	-2.1	0.3	-0.4	1.4
Mouth/teeth dental problems	1.3	2.0	4.2	2.1	2.0	-1.3	-1.0	-0.7	-0.7	-1.5
Heart attack	0.7	1.0	1.9	-1.3	-1.0	-1.3	1.4	0.2	0.3	-0.5
Allergy	1.0	2.2	5.9	-1.1	2.4	1.8	-0.8	1.1	0.8	1.7
Pain all over the body in last month	0.3	0.3	1.0	-0.2	-0.1	0.8	0.4	0.1	1.0	0.5
Diabetes (self-reported)	1.3	2.0	8.1	-1.5	-0.9	-0.1	2.9	-0.5	1.5	0.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	2.2	1.0	0.3	1.5	1.0	-0.2	-0.3	-0.9
Medication: Ramipril	0.5	0.6	2.3	0.1	-0.7	-0.8	-0.4	0.8	1.5	0.4
Medication: Simvastatin	1.5	2.2	4.0	-1.9	-1.5	0.4	-0.1	1.1	1.9	2.0
Fluid intelligence score	0.8	1.6	3.4	0.9	-0.9	-1.8	-1.7	-1.0	-1.3	-0.9
Illnesses of siblings	0.2	0.2	0.8	0.0	0.1	-0.9	-0.3	-0.1	-0.1	-0.8
Neuroticism score	0.1	0.2	1.0	-1.0	0.0	-0.0	-0.1	0.6	0.3	0.5
Weight	0.3	1.5	5.9	0.1	1.4	-0.2	2.4	-1.0	-0.8	-1.1
Impedance of arm (right)	0.2	1.0	3.3	-0.0	0.3	0.2	-1.8	1.6	1.1	-0.2
Arm fat percentage (right)	0.3	1.1	5.0	-0.4	2.2	0.3	1.4	0.2	0.6	-0.5
Trunk fat-free mass	0.7	3.8	6.4	1.6	-0.2	-0.9	2.4	-2.5	-2.2	-2.5
Hip circumference	0.2	1.1	2.2	0.3	0.9	0.3	1.5	-1.1	-0.9	-1.5
Time employed in main current job	0.3	0.4	1.3	0.9	-0.1	-1.1	0.3	-0.2	-0.4	-0.2
Alcohol intake versus 10 years previously	0.4	0.7	1.7	-1.3	-0.5	0.5	1.1	0.7	0.8	0.1
Father’s age at death	0.4	0.6	1.7	-0.3	-0.2	1.2	-1.0	-0.1	0.1	1.3
Worrier / anxious feelings	1.4	2.6	6.4	-2.5	0.8	0.7	-1.3	1.2	2.0	1.9
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	3.2	-1.8	-0.3	-1.1	-1.3	0.7	0.8	0.8
Falls in the last year	0.9	1.2	3.2	-1.8	-1.4	-0.6	-0.8	-0.3	0.8	1.3
Hair/balding pattern: Pattern 3	1.9	2.9	10.0	-1.3	-0.6	-2.3	-3.2	0.5	0.8	1.4
Number of live births	1.4	2.0	5.2	1.2	1.6	-1.0	2.3	-1.4	-0.1	-1.4
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.3	-1.4	-1.1	-0.6	-1.5	-0.2	0.0	-1.0
Pulse rate	1.0	1.6	6.5	-0.1	2.5	-0.9	1.8	0.6	0.2	0.9
Happiness	0.3	0.4	0.8	0.6	-0.3	0.2	0.9	-0.5	-0.8	-0.7
Noisy workplace	0.8	1.0	2.1	-0.2	-0.8	-1.3	1.5	0.7	1.0	1.0
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.1	-0.7	-1.1	0.4	-0.4	0.5	-0.1	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.8	0.2	-0.2	0.3	-1.2	0.8	-1.3	0.8
Mouth/teeth dental problems: Dentures	0.8	1.3	4.8	-1.0	-1.7	0.4	2.2	0.2	0.5	0.3
Asthma	0.9	1.7	4.4	1.9	-0.2	-1.1	0.6	-1.4	-0.6	-2.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.4	-0.5	1.2	0.5	0.6	0.5	0.8	1.1
Medication: Cholesterol lowering	2.9	4.5	11.2	-2.3	-3.4	1.2	-1.0	1.4	2.5	2.0
Depression (self-reported)	0.4	0.5	1.6	-0.3	0.2	-0.4	-0.5	-1.1	-1.2	-0.4
Medication: Lansoprazole	0.4	0.4	1.8	-0.0	-0.7	-0.4	1.4	-0.4	-0.3	0.6
Prospective memory result	1.1	1.3	4.4	0.4	1.9	-0.2	2.1	-0.4	-0.0	-0.7
Lung cancer (father)	0.7	0.8	3.1	0.4	0.3	-0.6	-0.7	-1.8	-1.0	0.6
Illnesses of mother	1.3	1.6	6.1	1.3	-0.3	0.6	0.9	-0.7	-2.5	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.9	-0.5	-0.1	-1.0	-1.3	0.1	0.1	-1.4
Pulse wave Arterial Stiffness index	1.1	1.3	6.3	-0.0	-0.6	-0.8	-0.0	-1.3	-2.5	0.6
Impedance of arm (left)	0.2	0.9	2.6	0.1	0.3	0.0	-1.4	1.6	1.1	0.1
Arm fat mass (right)	0.3	1.2	3.8	-0.0	2.0	0.2	1.9	-0.3	-0.1	-0.7
Trunk predicted mass	0.6	3.6	6.2	1.5	-0.2	-0.8	2.3	-2.5	-2.1	-2.5
Standing height	0.2	2.5	5.4	1.4	-0.6	-1.4	0.4	-1.7	-2.3	-2.2
Length of working week for main job	0.7	0.8	2.8	1.7	0.2	0.0	-1.1	-0.5	-1.1	0.1
Exposure to tobacco smoke at home	1.7	1.9	6.6	-0.2	0.8	0.4	2.6	-1.1	-0.3	-2.1
Breastfed as a baby	0.2	0.2	0.6	-0.8	-0.6	0.2	-0.4	0.3	-0.2	0.6
Tense / ‘highly strung’	0.3	0.4	1.0	-1.0	-0.6	-0.4	-0.5	0.6	0.5	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	2.2	0.0	0.3	-1.5	0.1	-1.2	-0.8	0.4
Hair/balding pattern: Pattern 4	6.1	14.7	51.7	-7.2	-1.5	1.6	-1.4	4.2	3.4	3.9
Birth weight of first child	0.9	1.6	4.3	0.6	-1.8	-0.1	0.9	-1.1	-2.1	-1.0
Peak expiratory flow (PEF)	0.2	0.4	1.7	-0.2	0.5	0.5	-0.5	-0.1	0.3	-1.3
Pulse wave reflection index	1.6	1.9	7.7	0.4	-0.8	0.9	0.1	-2.0	-2.8	-0.5
Ever highly irritable/argumentative for 2 days	1.0	1.1	2.9	0.8	1.7	-0.6	1.0	-1.4	-0.7	-0.8
Loud music exposure frequency	0.5	0.6	3.0	1.7	0.7	-0.1	0.1	0.0	-0.4	-0.6
Qualifications: O levels/GCSEs or equivalent	1.2	1.8	7.8	-1.1	-0.9	-0.2	-2.8	0.3	-1.6	0.6
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	8.2	-1.9	-0.5	2.9	0.1	1.7	0.6	1.5
Blood clot in the leg (DVT)	0.3	0.4	1.8	0.6	0.3	-1.4	0.5	0.0	-0.4	0.4
Medication: Paracetamol	0.6	1.0	5.5	-0.8	0.7	-2.3	-0.1	0.1	-0.2	0.8
Headache pain in last month	0.7	1.1	3.6	-1.5	-0.5	0.6	0.6	0.7	1.9	0.8
Medication for cholesterol, blood pressure or diabetes	2.3	3.8	7.4	2.3	2.4	-1.4	0.9	-1.5	-2.7	-1.6
Glaucoma (self-reported)	1.2	1.4	5.5	-0.9	0.8	-2.4	-1.1	0.5	-1.0	0.4
Gout (self-reported)	1.0	1.3	3.6	-1.9	0.2	-0.1	-0.2	1.3	1.1	1.6
Hypothyroidism/myxoedema (self-reported)	1.8	3.5	9.1	1.0	1.4	-2.2	3.0	-1.4	-1.1	-2.1
Medication: Amlodipine	0.2	0.2	1.4	-0.1	0.0	0.3	1.2	-0.3	-0.2	-0.3
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.7	0.2	-0.0	-0.2	0.8	-1.3	-0.8	-0.5
Birth weight	0.5	1.2	3.2	1.8	-0.3	0.0	0.6	-1.5	-0.4	-1.4
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.3	-1.1	1.1	-0.2	-1.3	1.2	0.8	1.5
High blood pressure (siblings)	0.3	0.4	1.1	0.6	-1.1	-0.0	-0.7	-0.9	0.2	0.1
Forced vital capacity (FVC), Best measure	0.2	0.8	1.4	-0.7	-1.0	-1.0	-1.2	0.6	0.3	-1.1
Body fat percentage	0.3	1.2	4.0	-1.2	2.0	0.2	0.9	0.8	1.1	0.3
Leg fat percentage (right)	0.3	1.2	3.3	-1.8	1.6	0.2	0.9	0.5	1.1	0.2
Arm fat-free mass (right)	0.5	2.4	5.2	1.3	0.4	-0.4	2.3	-2.1	-1.7	-1.6
Exposure to tobacco smoke outside home	0.9	1.2	4.1	-2.0	-1.4	0.4	-0.1	1.2	0.8	0.2
Comparative body size at age 10	0.5	1.3	4.9	-0.9	0.1	2.2	0.5	1.6	0.4	0.7
Number of full brothers	0.2	0.2	0.4	0.5	-0.4	0.6	0.4	0.3	0.6	-0.0
Worry too long after embarrassment	0.4	0.7	1.8	0.7	0.4	-0.8	-0.5	-1.4	-0.9	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.0	0.2	-0.2	-1.4	0.7	-1.4	-0.7	-0.8
Wheeze or whistling in the chest in last year	0.5	0.9	1.4	-1.2	-0.6	-0.0	1.1	0.7	1.2	1.1
Number of children fathered	0.4	0.5	1.7	1.0	-0.2	0.1	-1.3	-0.4	-0.7	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	5.2	-0.3	-2.3	0.1	-0.4	0.1	-0.2	1.0
Age at first live birth	1.4	2.5	6.5	2.4	-0.6	-0.6	-0.5	-1.7	-2.5	-1.0
Pulse wave peak to peak time	1.0	1.2	5.1	0.3	0.4	0.9	-0.0	1.2	2.2	-0.7
Health satisfaction	1.9	2.5	7.8	-2.4	0.1	2.8	-0.3	0.8	0.6	1.6
Shortness of breath walking on level ground	2.0	2.4	6.9	-2.6	-1.5	0.9	-0.8	0.6	1.2	2.1
Qualifications: College or University degree	0.8	2.6	11.9	1.0	-0.2	3.5	-0.0	-0.3	-1.1	-2.0
Eye problems/disorders: None of the above	1.0	1.1	3.3	0.4	1.4	1.8	0.3	0.9	1.0	0.9
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.6	0.6	-0.8	0.6	0.5	0.1	0.1	0.7
Emphysema/chronic bronchitis	0.2	0.2	0.6	0.1	-0.5	-0.7	0.2	-0.2	-0.8	0.4
Medication for pain relief, constipation, heartburn	0.8	1.4	3.4	1.9	-0.8	0.9	-0.1	-0.9	-1.3	-1.5
Neck or shoulder pain in last month	0.3	0.5	1.6	0.8	0.2	-1.3	0.3	-0.3	0.8	0.4
Medication: Blood pressure	0.7	1.2	2.8	-1.7	-0.7	-0.1	-0.0	1.2	1.6	0.9
Angina (self-reported)	2.2	2.9	8.0	-2.2	0.7	0.4	0.0	2.2	2.8	1.3
Migraine (self-reported)	0.1	0.1	0.4	-0.1	0.4	0.6	-0.2	-0.1	-0.2	0.3
Medication: Ibuprofen	0.4	0.5	1.4	0.6	1.2	0.3	0.9	-0.6	0.4	-0.0
Medication: Allopurinol	0.3	0.4	1.3	-0.7	-0.4	0.2	0.6	0.6	-0.3	1.2
Medication: Omeprazole	0.3	0.3	1.1	-0.6	-0.1	-0.4	-0.5	-0.1	0.5	1.1
Medication: Seretide 50 evohaler	0.9	1.1	2.1	-1.2	-1.0	1.4	1.4	-0.4	-0.9	0.5
Mean time to correctly identify matches	0.3	0.6	2.0	-0.4	-0.6	-1.4	0.8	1.0	0.1	0.4
Heart disease (mother)	0.8	1.0	3.5	-0.8	0.9	0.3	-1.4	0.2	1.9	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.6	-0.9	-0.8	-1.0	-0.5	0.3	1.6	1.4
Whole body fat mass	0.2	1.0	3.5	-0.4	1.9	-0.1	1.7	-0.2	0.1	-0.5
Leg fat mass (right)	0.2	0.9	3.0	-0.7	1.6	0.0	1.7	-0.5	0.1	-0.6
Arm predicted mass (right)	0.4	2.3	5.2	1.1	0.4	-0.7	2.3	-1.9	-1.5	-1.7
Pulse rate, automated reading	0.3	0.9	4.3	-1.1	0.1	-0.5	0.3	0.9	-0.1	2.1
Alcohol intake frequency.	0.3	0.7	2.4	-0.5	0.9	-0.5	1.6	0.7	0.7	-0.2
Comparative height size at age 10	0.2	1.0	3.2	-0.8	-0.9	0.7	-0.6	0.8	1.8	0.8
Number of full sisters	0.9	1.1	2.9	-1.7	-1.1	0.9	1.3	0.5	0.1	0.9
Suffer from ‘nerves’	1.0	1.6	4.0	0.0	-0.3	-1.6	0.4	-2.0	-1.7	-1.3
Overall health rating	0.5	1.0	5.1	-2.2	-0.5	-0.5	0.6	0.2	1.0	0.4
Chest pain or discomfort	1.5	2.1	8.5	-2.9	-0.4	-0.2	0.6	0.6	2.2	0.4
Had major operations	0.3	0.4	1.3	-0.3	-0.3	-0.4	-0.4	-0.1	0.8	1.1
Age at last live birth	1.8	2.6	7.2	2.6	0.8	0.1	-0.5	-1.5	-2.7	-1.1
Family relationship satisfaction	0.4	0.5	1.5	0.2	-0.1	1.0	0.1	-1.0	-0.6	-1.2
Leg pain on walking	0.2	0.3	1.3	-0.2	-0.4	-1.1	0.3	-0.0	-0.2	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	4.5	1.1	-0.7	-0.7	0.7	0.5	0.3	2.1
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.0	-0.5	0.1	-0.5	0.0	1.0	0.1	0.8
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.3	-0.1	-0.4	-0.6	0.9	0.3	1.2	-0.5
Medication: Aspirin	1.3	1.7	3.9	-2.0	-1.4	-0.8	-0.1	0.9	1.9	1.1
Supplements: Vitamin C	1.1	1.2	2.2	0.2	1.2	-0.2	-1.3	1.2	-1.3	1.5
Knee pain experienced in last month	0.6	1.0	2.2	0.2	1.4	-1.5	-0.0	-1.1	-1.0	0.7
Hypertension (Self-reported)	0.6	1.6	6.2	-1.7	0.1	-2.5	0.9	0.6	1.1	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.9	0.1	-0.2	-0.2	0.4	-0.9	0.1	0.5
Illnesses of father: Heart disease	0.6	0.8	3.0	1.2	1.7	-0.4	0.3	-0.1	0.8	-0.6
Illnesses of siblings: Diabetes	0.4	0.5	2.1	-0.6	-0.6	0.2	-0.2	0.4	0.7	1.4
Smoking status: Previous	0.6	0.9	5.0	0.3	0.5	-2.2	0.8	-0.1	0.2	0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	5.6	2.2	1.0	-0.7	0.9	-1.6	-0.8	-2.4
Whole body fat-free mass	0.7	4.1	7.5	1.6	0.2	-0.7	2.7	-2.5	-2.4	-2.5
Leg fat-free mass (right)	0.8	4.2	10.0	1.7	0.5	-0.4	3.2	-2.2	-2.4	-2.3
Arm fat percentage (left)	0.3	1.1	4.2	-0.4	2.0	0.3	1.6	0.3	0.8	-0.3
Average weekly red wine intake	0.9	1.3	5.0	1.4	-0.4	1.1	-2.2	-0.5	0.2	0.5
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.9	0.1	-0.6	-1.2	1.7	-0.1	0.5	-0.2
Mood swings	0.8	1.4	4.0	-0.3	-0.6	0.1	-0.6	1.5	1.6	2.0
Loneliness, isolation	0.1	0.1	0.6	-0.4	0.7	-0.2	-0.2	0.0	-0.4	-0.1
Long-standing illness, disability or infirmity	1.0	1.6	4.2	-0.6	-0.1	-1.3	2.1	-1.4	0.7	-1.4
Ever had bowel cancer screening	0.7	0.9	2.8	-0.3	-1.7	0.5	1.6	-0.4	0.1	0.4
Diabetes diagnosed by doctor	1.3	2.2	10.1	-1.6	-0.0	-0.0	3.2	-0.7	1.4	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.3	5.9	-1.6	-1.0	1.3	-0.8	1.6	1.3	2.4
Friendships satisfaction	1.0	1.2	3.2	-0.7	1.7	0.5	-0.5	1.2	1.8	-0.5
Qualifications: nursing, teaching	0.2	0.3	0.5	0.5	0.7	0.5	-0.6	-0.4	-0.7	-0.3
Commuting to job workplace: Walk	0.3	0.3	1.3	0.7	0.2	-0.1	-0.2	-0.3	-1.1	-0.4
Eye problems/disorders: Cataract	1.8	2.1	4.4	-2.1	-2.0	-0.6	-1.1	1.8	0.8	1.0
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.3	0.2	-0.5	-1.6	0.8	-1.8	-1.4	-0.4
Medication for cholesterol	1.8	2.7	7.1	2.7	1.6	-0.2	-2.2	-1.0	-1.7	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	3.9	-1.4	0.9	-0.6	-0.4	2.0	1.4	1.1
Back pain experienced in last month	1.7	2.5	4.9	-2.1	0.7	1.1	-0.9	1.4	1.9	2.2
Mineral and other dietary supplements	0.2	0.3	0.6	0.2	0.7	-0.6	-0.3	-0.7	-0.8	-0.0
Breast cancer (self-reported)	0.6	0.7	2.4	-0.2	-1.6	-0.7	0.1	0.3	-1.0	1.0
Asthma (self-reported)	0.8	1.7	3.9	1.7	-0.0	-1.4	0.8	-1.4	-0.6	-2.0
Osteoporosis (self-reported)	1.1	1.3	2.5	-1.5	-0.7	1.2	-0.4	1.2	1.6	1.0
Osteoarthritis (self-reported)	0.2	0.3	1.3	-0.6	-0.3	-0.3	-1.1	0.2	0.0	0.2
Medication: Aspirin	1.2	1.6	3.6	-1.8	-1.2	-1.2	0.2	0.8	1.9	0.9
Medication: Gliclazide	1.7	1.9	2.7	1.1	-1.2	-1.6	1.2	-1.4	-1.6	-1.6
Illnesses of father: None of the above (group 1)	0.3	0.4	0.8	-0.5	0.2	-0.6	-0.6	-0.7	-0.9	-0.8
Smoking status: Current	0.7	1.2	2.9	-1.0	1.0	1.7	-0.8	0.8	0.9	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.7	-0.8	-0.2	-0.5	-0.3	0.6	1.3	-0.1
Whole body water mass	0.7	3.8	6.7	1.5	0.2	-0.7	2.6	-2.4	-2.3	-2.5
Leg predicted mass (right)	0.7	3.9	9.1	1.7	0.4	-0.4	3.0	-2.2	-2.4	-2.2
Arm fat mass (left)	0.3	1.2	4.2	-0.1	1.8	0.0	2.0	-0.4	0.1	-0.8
Number of self-reported non-cancer illnesses	0.4	0.7	1.4	-0.2	0.1	-1.2	1.2	-0.5	1.2	-0.5
Average weekly champagne plus white wine intake	1.8	2.5	6.3	0.2	-2.0	2.5	-2.5	-0.4	-0.5	0.4
Miserableness	0.2	0.4	0.8	-0.8	-0.3	0.5	0.2	0.7	0.9	0.7
Guilty feelings	0.1	0.2	0.9	0.2	0.2	-0.5	-0.1	-0.1	-0.9	-0.5
Wears glasses or contact lenses	0.9	1.0	4.3	-0.3	-1.1	1.1	-2.1	0.5	0.2	0.4
Ever taken oral contraceptive pill	1.1	1.3	3.6	-0.6	0.5	-0.4	-1.9	0.7	0.9	1.7
Hearing aid user	1.7	1.9	5.8	2.4	-0.2	-0.4	1.1	-1.1	-0.3	-2.1
Mother’s age at death	0.3	0.4	0.8	0.9	-0.7	0.5	-0.5	-0.3	-0.8	0.7
Financial situation satisfaction	1.4	1.7	3.1	-0.9	-0.4	0.5	-1.7	1.8	1.6	1.6
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.7	-0.1	0.6	0.8	-1.3	0.4	-0.0	1.0
Commuting to job workplace: Public transport	1.0	1.2	3.0	1.2	0.2	0.7	-1.4	-1.1	-1.7	-0.7
Eye problems/disorders: Glaucoma	0.9	1.0	2.7	-1.6	-0.2	-1.0	-1.1	0.9	-0.0	1.2
Medication: Blood pressure	0.8	1.5	4.1	-2.0	0.4	-0.6	1.9	0.4	0.7	-1.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.4	-1.6	0.5	-0.8	0.3	0.5	0.3	0.2
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.5	0.3	-0.6	1.2	0.4	0.9	1.2	-0.3
High cholesterol (Self-reported)	3.7	6.5	17.6	-3.3	-1.1	0.3	-1.3	2.9	4.2	2.4
Medication: Bendroflumethiazide	1.0	1.5	3.6	-1.9	-0.6	-0.2	1.1	1.4	1.7	0.7
Medication: Paracetamol	0.5	0.8	4.1	-0.5	0.2	-2.0	0.4	-0.5	-0.9	0.0
Medication: Lisinopril	0.9	1.2	4.5	-0.8	2.1	0.0	1.2	0.7	1.2	0.0
Medication: Atorvastatin	3.2	4.0	11.7	-2.8	-0.9	1.0	1.1	2.4	3.4	0.1
Illnesses of father: High blood pressure	0.3	0.4	1.1	-1.0	0.1	0.5	0.6	-0.1	0.8	0.8
Alcohol drinker status: Never	0.5	0.6	1.5	0.1	-0.4	-1.2	0.9	-1.2	-0.5	-0.4
Ever smoked	1.3	2.2	5.2	-1.9	-0.4	0.4	-1.7	1.6	0.9	2.3
Basal metabolic rate	0.6	3.3	6.8	1.3	0.7	-0.6	2.6	-2.2	-2.0	-2.2
Leg fat percentage (left)	0.3	1.2	3.5	-1.9	1.5	0.1	1.1	0.7	0.7	0.6
Arm fat-free mass (left)	0.5	2.3	4.7	0.8	0.3	-0.6	2.2	-2.0	-1.9	-1.8
Number of operations (self-reported)	0.2	0.3	0.7	-0.4	-0.3	-0.3	0.4	-0.4	0.8	0.8
Average weekly beer plus cider intake	2.9	4.3	10.0	1.7	1.1	-2.0	2.9	-1.4	-1.2	-3.2
Irritability	0.5	0.8	2.2	-1.4	-1.5	0.3	0.8	0.6	-0.3	0.6
Risk taking	0.9	1.4	4.3	0.8	0.7	1.1	2.1	-1.0	-1.0	-0.7
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.6	-0.8	0.1	1.3	-1.1	-0.5	-0.1	0.5
Fractured/broken bones in last 5 years	0.6	0.7	2.3	1.2	1.0	0.5	-0.1	0.3	1.5	-0.2
Age started oral contraceptive pill	1.7	2.1	6.9	0.4	0.1	0.6	1.8	-1.1	-1.7	-2.6
Diastolic blood pressure, automated reading	0.4	1.1	2.9	-1.1	0.5	-0.4	0.3	1.7	0.6	1.7
Ever depressed for a whole week	0.5	0.6	2.2	0.2	0.9	1.5	-0.5	0.1	-0.4	0.7
Unable to work because of sickness or disability	0.4	0.5	1.0	-0.7	-0.9	-0.1	1.0	0.1	0.9	0.7
Commuting to job workplace: Cycle	0.2	0.2	0.6	0.7	-0.2	0.8	0.1	0.3	0.5	0.2
Myopia	0.8	1.1	4.2	-0.5	-1.6	2.0	-0.6	0.3	0.1	-0.7
Vascular/heart problems diagnosed by doctor	0.9	2.3	5.6	2.2	0.4	2.4	-0.6	-1.2	-1.9	-0.6
Cholesterol lowering medication	1.1	1.6	4.6	-1.9	-0.1	-0.2	1.2	1.1	2.1	0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.5	-0.5	-0.3	-0.3	-0.2	-0.3	0.4	0.7
Pain experienced in last month	1.3	2.1	6.3	1.9	0.3	-0.4	1.0	-0.9	-1.8	-2.5
Supplements: Calcium	0.7	0.8	1.8	-1.0	-0.5	1.4	-0.4	1.3	0.3	0.9
Basal cell carcinoma (self-reported)	2.8	3.3	7.8	2.5	1.5	-0.1	-0.1	-2.8	-2.0	-1.8
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.3	-1.2	-0.7	-1.1	1.5	0.1	0.5	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.3	0.6	0.7	-1.1	0.9	-0.2	-0.3	0.1
Heart disease (siblings)	1.2	1.5	4.2	-2.0	-0.1	-0.9	1.4	1.6	1.0	0.5
Alcohol drinker status: Previous	0.3	0.4	1.7	-0.4	1.3	-0.3	0.6	0.2	-0.6	-0.2
Pack years of smoking	0.1	0.2	0.6	-0.5	-0.4	0.0	-0.1	0.1	0.7	0.8
Impedance of whole body	0.6	2.9	7.3	-0.9	0.7	0.2	-2.7	2.5	2.1	1.2
Leg fat mass (left)	0.2	0.9	3.4	-0.7	1.5	-0.1	1.9	-0.4	-0.2	-0.3
Arm predicted mass (left)	0.4	1.9	4.2	0.7	0.5	-0.5	2.1	-1.7	-1.6	-1.6