Best TWAS P=5.31e-19 · Best GWAS P=2.26e-25 conditioned to 2.03e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RSPO2 | 0.12 | 0.10 | blup | 471 | 0.13 | 3.3e-15 | 8.9 | 8.9 | 5.3e-19 | 0.50 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Testis | EMC2 | 0.28 | 0.06 | enet | 70 | 0.03 | 2.3e-02 | -3.3 | 5.3 | 9.9e-08 | 0.16 | 0.25 | 0.05 | TRUE |
| 3 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TTC35 | 0.10 | 0.07 | lasso | 3 | 0.07 | 6.6e-08 | 6.6 | -6.6 | 4.4e-11 | -0.08 | 0.00 | 1.00 | FALSE |
| 4 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EIF3E | 0.02 | 0.02 | blup | 38 | 0.01 | 1.5e-02 | 5.8 | -6.5 | 9.7e-11 | -0.30 | 0.04 | 0.68 | FALSE |