TWAS hub - EIF3E

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0730	0.0210	3.4e-10	0.069	0.094	0.082	0.094	0.085	7.9e-09	1.6e-11	3.1e-10	1.5e-11	1.7e-10
2	GTEx	Brain Cerebellum	0.1570	0.0810	5.5e-03	0.041	NA	0.086	NA	0.098	2.3e-02	NA	1.6e-03	NA	7.9e-04
3	YFS	Blood	0.0136	0.0062	1.2e-03	0.003	0.011	0.007	0.010	0.006	2.7e-02	1.4e-04	1.8e-03	2.6e-04	3.3e-03
4	TCGA	Lung Adenocarcinoma	0.0213	0.0162	3.1e-03	0.005	0.006	0.000	NA	0.003	7.2e-02	6.0e-02	2.8e-01	NA	1.5e-01
5	TCGA	Prostate Adenocarcinoma	0.0234	0.0145	2.2e-03	0.020	0.013	0.012	NA	0.010	3.2e-03	1.5e-02	1.6e-02	NA	3.0e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Lung FEV1/FVC ratio	10.6	53.5	66.8	8.1	6.2	8.2	7.7	6.1
Mean Putamen Volume	10.4	11.9	17.3	-4.0	-2.0	-2.4	-4.2	-4.0
Qualifications: CSEs or equivalent	10.0	13.2	17.6	-3.5	-4.2	-2.2	-3.9	-4.0
Bipolar Disorder (2011)	8.2	7.9	11.5	2.6	2.2	2.8	3.4	3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	7.7	9.0	14.6	-2.9	-1.8	-3.8	-3.1	-3.0
Tinnitus: Yes, but not now, but have in the past	7.3	7.8	10.7	-2.5	-2.2	-3.1	-3.3	-2.8
Family relationship satisfaction	7.0	8.6	12.5	-2.5	-3.0	-3.5	-3.0	-2.5
Hair/balding pattern: Pattern 4	6.7	16.3	41.9	-3.5	-1.2	0.1	-5.1	-6.5
Heel T-Score	6.4	50.8	84.1	7.2	5.3	4.6	8.2	9.2
Medication: Lisinopril	5.7	7.3	8.7	-2.9	-2.9	-2.6	-2.5	-2.6
HbA1C	5.5	6.1	7.2	-2.2	-2.3	-2.7	-2.6	-2.6
Pulse rate	5.3	9.0	11.7	3.1	2.7	3.1	3.4	2.6
Chest pain or discomfort	5.3	7.6	9.2	-2.5	-2.5	-3.0	-2.9	-2.8
Heel bone mineral density (BMD) T-score, automated (left)	5.0	11.3	15.7	3.6	2.6	2.5	3.9	4.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.6	9.6	12.7	3.0	3.3	3.6	2.9	2.7
Worry too long after embarrassment	4.5	7.6	10.0	-2.6	-2.6	-2.2	-3.1	-3.2
Number of full sisters	4.2	5.1	6.2	2.1	2.2	2.5	2.4	2.1
Guilty feelings	4.2	6.3	11.1	-2.1	-1.9	-2.0	-2.9	-3.3
Handedness (chirality/laterality): Left-handed	4.0	4.8	6.5	2.1	2.0	1.5	2.5	2.5
Heel bone mineral density (BMD) T-score, automated (right)	3.9	9.0	12.9	3.0	2.5	2.3	3.6	3.5
Qualifications: None of the above	3.9	8.4	14.9	-2.6	-2.4	-3.9	-2.8	-2.7
Friendships satisfaction	3.8	4.7	5.7	-1.9	-2.3	-2.0	-2.4	-2.2
Back pain experienced in last month	3.4	4.9	6.4	-2.3	-1.8	-1.9	-2.5	-2.5
Ulcerative Colitis	3.3	4.7	7.2	-2.6	-0.4	-1.9	-2.4	-2.7
Qualifications: College or University degree	3.3	10.4	12.3	3.1	2.5	3.4	3.5	3.5
Supplements: Calcium	3.3	3.6	6.7	2.2	2.6	1.6	1.5	1.2
Eye problems/disorders: Diabetes related eye disease	3.2	3.5	5.7	-2.4	-0.5	-1.8	-2.1	-1.9
Chronotype (morning person)	3.1	7.1	8.6	2.9	2.1	2.4	2.9	2.8
Supplements: Zinc	3.1	3.4	5.9	2.4	1.6	1.7	1.6	1.6
Stomach or abdominal pain in last month	3.1	3.9	6.5	-1.6	-1.8	-2.6	-2.1	-1.7
Ever highly irritable/argumentative for 2 days	3.1	3.8	4.7	-1.9	-1.5	-2.2	-2.2	-1.9
Overall health rating	3.1	6.7	12.1	-2.8	-0.9	-2.5	-2.6	-3.5
Medication: Omeprazole (e.g. Zanprol)	3.0	3.7	5.0	-1.6	-2.2	-2.0	-1.9	-1.8
Frequency of tiredness / lethargy in last 2 weeks	2.8	4.5	7.1	-1.9	-2.1	-1.7	-2.1	-2.7
Medication: Omeprazole	2.8	3.4	5.1	-1.5	-2.3	-1.8	-1.7	-1.7
Average weekly champagne plus white wine intake	2.8	3.8	5.6	2.2	1.0	1.6	2.3	2.4
Illnesses of father: Heart disease	2.7	3.7	5.4	-1.9	-0.6	-2.3	-2.0	-2.3
Hair Pigment	2.6	72.8	132.2	8.1	7.9	11.5	8.2	6.1
Exposure to tobacco smoke outside home	2.6	3.5	6.4	-1.4	-2.5	-0.8	-1.7	-2.4
Commuting to job workplace: Cycle	2.6	3.2	4.3	1.9	1.3	1.5	1.9	2.1
Ovarian Cancer	2.5	3.3	5.1	-2.2	-0.6	-2.0	-2.1	-1.6
Peak expiratory flow (PEF)	2.5	5.8	7.2	2.3	1.9	2.6	2.4	2.7
Neuroticism (Nagel 2018)	2.4	5.6	11.8	-2.1	-1.8	-1.3	-2.5	-3.4
Wheeze or whistling in the chest in last year	2.4	4.2	6.1	-2.1	-1.7	-2.5	-1.8	-2.1
Illness, injury, bereavement, stress in last 2 years	2.4	3.0	4.3	1.5	2.1	1.8	1.6	1.6
Sensitivity / hurt feelings	2.3	3.9	5.9	-2.0	-1.1	-1.8	-2.4	-2.4
Loud music exposure frequency	2.3	2.5	6.0	-1.1	-2.4	-1.5	-1.5	-0.8
Illnesses of siblings: Diabetes	2.3	2.8	5.4	-1.6	-0.8	-1.4	-2.0	-2.3
Wears glasses or contact lenses	2.3	2.6	5.2	2.3	-0.3	1.8	1.6	1.5
Schizophrenia (2018)	2.2	4.6	8.1	-2.8	0.2	-1.2	-2.4	-2.8
Neuroticism (2016)	2.2	3.1	6.8	-1.4	-2.6	-1.6	-1.4	-1.6
Pulse wave reflection index	2.2	2.7	3.8	-1.1	-1.6	-2.0	-1.8	-1.6
Leg pain on walking	2.2	2.7	4.1	1.4	1.5	1.4	1.9	2.0
Loneliness, isolation	2.2	3.0	6.5	-1.5	-0.1	-1.5	-2.0	-2.5
Pain experienced in last month	2.2	3.7	5.7	1.6	2.4	1.9	1.8	1.7
Number of self-reported non-cancer illnesses	2.0	3.4	7.8	-1.5	-1.4	-2.8	-1.4	-1.7
Schizophrenia vs Biploar Disorder	1.9	2.6	5.6	-1.6	-0.7	-2.4	-1.6	-1.2
Nervous feelings	1.9	3.6	5.0	-1.4	-2.0	-1.5	-2.2	-2.2
Neuroticism score	1.9	4.0	8.4	-1.6	-1.4	-1.3	-2.3	-2.9
Worrier / anxious feelings	1.9	3.5	6.7	-1.6	-1.4	-1.6	-2.0	-2.6
Schizophrenia (2014)	1.8	3.9	7.6	-2.8	0.5	-0.8	-2.1	-2.6
Bipolar Disorder (2018)	1.7	2.7	5.4	0.4	2.3	2.0	1.5	1.3
Coronary Artery Disease (CAD)	1.7	2.1	5.1	-1.3	-0.8	-2.3	-1.4	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	6.5	-1.3	-1.6	-1.0	-2.4	-2.6
Mother’s age at death	1.7	2.1	5.5	-0.7	-2.3	-1.2	-1.4	-1.0
Lupus	1.6	2.4	3.1	1.7	1.2	1.3	1.7	1.8
Triglycerides	1.6	2.6	3.6	-1.9	-1.7	-1.6	-1.8	-1.0
Neuroticism	1.6	3.8	9.3	-1.5	-1.5	-1.1	-2.0	-3.1
Number of treatments/medications taken	1.6	2.8	4.4	-1.9	-0.1	-1.9	-1.7	-2.1
Medication: Atenolol	1.6	2.0	3.3	-1.3	-0.9	-1.8	-1.4	-1.5
Mouth/teeth dental problems: Dentures	1.6	2.6	9.4	0.8	3.1	1.3	1.1	0.0
Medication: Lansoprazole	1.6	1.9	3.4	-1.3	-0.7	-1.9	-1.3	-1.4
Hearing aid user	1.6	1.8	3.5	0.4	0.7	1.1	1.9	1.9
Depressed Affect (Nagel 2018)	1.5	3.1	8.2	-1.8	-0.8	-0.5	-1.8	-2.9
Ulcerative Colitis (UC)	1.5	2.9	4.6	-2.1	0.2	-1.7	-1.8	-2.0
Height	1.5	29.7	42.6	-5.6	-5.0	-4.1	-6.5	-5.7
Forced expiratory volume in 1-second (FEV1)	1.5	5.2	9.7	2.0	1.5	3.1	2.3	2.2
Standing height	1.4	13.6	18.8	-3.9	-3.5	-2.7	-4.3	-3.8
Length of working week for main job	1.4	1.6	2.8	1.7	-0.0	1.3	1.5	1.1
Glaucoma (self-reported)	1.4	1.6	3.0	-1.6	-1.0	-1.7	-1.0	-0.9
Illnesses of father: None of the above (group 1)	1.4	1.7	4.4	1.0	1.1	2.1	0.9	1.0
Financial situation satisfaction	1.4	1.7	3.9	-0.8	-0.8	-1.1	-1.4	-2.0
Number of operations (self-reported)	1.4	2.0	6.1	0.7	2.5	0.7	1.5	0.9
Lung FVC	1.3	6.7	9.7	1.3	2.9	3.1	2.8	2.4
Happiness	1.3	1.6	3.5	-1.4	-0.2	-0.8	-1.4	-1.9
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	4.8	-0.9	-2.2	-0.9	-0.9	-0.2
Comparative body size at age 10	1.3	3.6	6.4	2.1	0.7	1.4	2.2	2.5
Migraine (self-reported)	1.3	1.6	3.1	-1.8	-1.1	-1.3	-0.9	-1.1
Mood swings	1.3	2.3	5.6	-1.7	-0.5	-0.3	-1.6	-2.4
Miserableness	1.3	2.3	5.0	-1.2	-1.2	-0.4	-1.8	-2.2
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.9	-1.2	-0.1	-0.8	-1.6	-2.0
Angina	1.2	1.5	4.5	-1.0	-0.9	-2.1	-1.1	-0.4
Prospective memory result	1.2	1.5	2.9	0.6	1.0	1.7	1.4	1.1
Medication: Gliclazide	1.2	1.3	2.1	-1.5	-0.3	-1.2	-1.1	-1.3
Fractured/broken bones in last 5 years	1.2	1.5	2.2	-1.5	-0.4	-1.5	-1.2	-1.2
Heart disease (siblings)	1.2	1.4	3.3	-1.0	-0.0	-0.9	-1.4	-1.8
Verbal and Numeric Reasoning (VNR)	1.1	2.7	3.8	1.8	0.7	1.7	1.7	1.9
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	2.7	1.4	1.6	1.5	1.1	0.6
Fluid intelligence score	1.1	2.2	3.5	1.6	0.7	1.9	1.4	1.6
Headache pain in last month	1.1	1.9	3.6	-1.3	-1.2	0.1	-1.6	-1.9
Medication: Blood pressure	1.1	1.9	4.8	-0.9	-2.2	-1.8	-0.8	-0.2
Medication: Allopurinol	1.1	1.5	3.5	-1.2	-0.8	-1.9	-1.2	-0.7
Medication: Seretide 50 evohaler	1.1	1.3	2.4	-1.5	-0.6	-1.3	-1.2	-1.0
Myopia	1.1	1.6	2.0	1.0	1.3	1.4	1.4	1.2
Cholesterol lowering medication	1.1	1.7	4.0	-1.3	-1.2	-2.0	-0.8	-0.7
Worry (Nagel 2018)	1.0	2.1	4.9	-1.3	-1.0	-0.8	-1.4	-2.2
Prostate Cancer	1.0	1.4	2.2	1.4	0.5	1.5	0.9	1.4
HDL Cholesterol	1.0	1.7	3.8	0.9	1.9	1.4	1.4	0.4
Vitamin and mineral supplements	1.0	1.3	2.7	-0.8	-1.5	-1.6	-0.7	-0.5
Hand grip strength (right)	1.0	2.6	8.2	-1.3	-2.9	-0.1	-1.6	-0.6
Time employed in main current job	1.0	1.2	2.7	0.7	1.0	1.6	1.1	0.6
Breastfed as a baby	1.0	1.2	3.0	1.2	-0.2	0.6	1.1	1.7
Mouth/teeth dental problems: Bleeding gums	1.0	1.2	3.1	-1.8	-0.6	-0.8	-0.9	-1.1
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.7	0.6	-0.0	0.0	1.6	1.6
Angina (self-reported)	1.0	1.3	3.9	-0.9	-1.0	-2.0	-1.0	-0.3
Medication for cholesterol	1.0	1.4	2.7	1.4	0.8	1.6	1.1	0.8
Average weekly beer plus cider intake	1.0	1.4	2.8	-1.2	-0.2	-1.7	-1.3	-1.2
Body Mass Index (BMI) (2010)	0.9	1.2	2.5	-0.6	-1.5	-1.6	-0.8	-0.2
Smoking Status	0.9	2.3	3.6	1.1	0.4	1.9	1.9	1.7
Medication for hormone replacement therapy	0.9	1.0	1.8	-1.3	-0.0	-0.7	-1.1	-1.4
Severe depression (siblings)	0.9	1.1	1.7	-1.0	-1.3	-0.9	-0.9	-0.9
Supplements: Glucosamine	0.9	1.1	2.6	0.8	1.2	1.6	0.9	0.4
Sitting height	0.9	6.6	10.4	-2.6	-3.2	-1.9	-2.7	-2.2
Had other major operations	0.9	1.1	2.1	0.5	1.3	1.4	1.0	0.4
Heart attack	0.9	1.1	3.3	-1.3	0.2	-1.8	-0.7	-0.2
Allergy	0.9	2.1	3.5	1.2	1.9	1.6	1.3	1.2
Trunk fat-free mass	0.9	5.1	12.5	-1.5	-3.5	-1.7	-2.3	-1.6
Number of live births	0.9	1.3	1.9	0.8	0.8	1.3	1.3	1.4
Trunk predicted mass	0.9	5.0	12.3	-1.5	-3.5	-1.6	-2.3	-1.6
Blood clot in the leg (DVT)	0.9	1.1	1.8	1.1	0.8	0.6	1.3	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	1.9	1.4	1.2	0.6	0.8	1.1
Arm predicted mass (right)	0.9	4.5	11.3	-1.1	-3.4	-1.6	-2.2	-1.6
Pulse rate, automated reading	0.9	3.0	5.7	2.4	0.2	1.7	1.8	1.8
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	1.9	1.1	0.8	0.5	1.4	1.4
Bipolar Disorder or Schizophrenia	0.8	1.8	3.8	-1.9	1.6	0.3	-0.9	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	3.2	-0.7	-0.2	-0.4	-1.1	-1.8
Had menopause	0.8	1.0	3.1	0.5	1.8	0.4	0.8	0.7
Hip circumference	0.8	3.2	4.6	-1.1	-2.1	-1.8	-2.1	-1.7
Arm fat-free mass (right)	0.8	4.1	11.1	-1.1	-3.3	-1.5	-2.0	-1.4
Number of full brothers	0.8	1.1	1.8	-1.0	-0.6	-1.3	-1.0	-1.1
Comparative height size at age 10	0.8	4.6	6.8	-2.6	-2.1	-0.9	-2.4	-2.2
Average weekly red wine intake	0.8	1.2	3.2	0.4	-1.3	-1.8	-0.0	1.1
Commuting to job workplace: Walk	0.8	0.9	1.2	-0.8	-0.8	-1.1	-1.0	-1.0
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.3	-1.1	0.1	-1.8	-0.7	-0.2
Alcohol drinker status: Previous	0.8	0.9	2.0	0.9	1.4	0.7	0.8	0.6
Depression (Nagel 2018)	0.7	1.0	3.1	-0.8	-0.2	-0.3	-1.0	-1.8
Blood White Count	0.7	5.0	9.5	2.6	-0.1	1.8	2.3	3.1
Ever had hysterectomy (womb removed)	0.7	0.8	1.8	0.6	-1.3	0.2	0.7	1.1
Current tobacco smoking	0.7	1.2	1.6	0.6	1.2	1.2	1.2	1.0
Maternal smoking around birth	0.7	0.9	1.7	0.2	1.3	1.2	0.8	1.0
Hayfever, allergic rhinitis or eczema	0.7	1.4	4.2	-0.7	-2.1	-1.2	-0.9	-0.5
Multivitamins +/- minerals	0.7	0.9	2.4	0.4	1.6	1.3	0.3	0.1
Chronic bronchitis/emphysema (father)	0.7	0.8	2.5	-0.2	-1.6	-1.1	-0.6	0.1
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.8	-0.7	-1.0	-1.7	-0.1	0.1
Father’s age at death	0.7	1.0	1.5	1.2	0.9	0.9	0.7	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	5.1	1.4	1.3	2.2	1.3	1.1
Number of children fathered	0.7	0.8	1.7	0.3	0.8	0.4	1.1	1.3
Suffer from ‘nerves’	0.7	1.0	2.0	-1.4	-0.8	-0.4	-0.9	-1.2
Medication: Aspirin	0.7	0.9	2.7	-0.7	-0.8	-1.6	-0.7	-0.5
Arm predicted mass (left)	0.7	3.5	9.1	-1.1	-3.0	-1.3	-1.9	-1.3
Waist Hip Ratio (WHR)	0.6	2.5	5.0	1.4	0.9	0.7	2.0	2.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	3.6	-0.4	1.9	-0.4	0.3	-0.4
Fed-up feelings	0.6	1.1	3.5	-0.9	-0.4	0.1	-0.9	-1.9
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.2	0.9	-0.4	0.7	1.1	1.0
Financial difficulties in last 2 years	0.6	0.8	2.2	-0.4	-0.3	-1.5	-0.9	-0.9
Falls in the last year	0.6	0.8	2.3	0.0	-1.5	-1.1	-0.4	-0.7
Medication: Cholesterol lowering	0.6	0.9	2.8	0.7	-0.1	-0.4	1.0	1.7
Illnesses of mother	0.6	0.7	1.9	0.4	1.0	1.4	0.7	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.6	-0.4	-1.6	-0.5	-0.8	-1.1
Whole body fat-free mass	0.6	3.3	9.6	-0.9	-3.1	-1.1	-1.8	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.1	0.4	-1.0	0.4	0.9	0.9
Arm fat-free mass (left)	0.6	3.1	8.6	-1.0	-2.9	-1.3	-1.7	-1.2
Ever had prostate specific antigen (PSA) test	0.6	0.6	2.1	0.6	0.6	1.5	0.5	0.3
Unable to work because of sickness or disability	0.6	0.8	1.5	1.0	1.2	0.3	0.9	0.6
Intelligence (Savage-Jansen 2018)	0.5	1.4	2.4	1.3	1.0	1.6	0.9	0.9
LDL Cholesterol	0.5	0.8	2.0	-0.6	-0.9	-1.4	-0.8	-0.1
Primary Biliary Cirrhosis	0.5	0.7	1.4	-1.2	-0.2	-0.4	-1.0	-1.1
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.0	0.9	0.7	0.1	0.8	1.0
Blood Eosinophil Count	0.5	3.7	5.0	2.2	1.3	1.8	2.1	2.1
Systolic Blood Pressure	0.5	2.5	5.7	-1.6	-2.4	-1.1	-1.3	-1.3
Tanning	0.5	5.7	9.5	2.2	3.1	1.4	2.4	2.5
Hand grip strength (left)	0.5	1.3	4.1	-1.1	-2.0	0.2	-1.0	0.1
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.3	-1.1	-0.2	-0.7	-0.7	-0.9
Impedance of leg (right)	0.5	2.4	3.6	-1.9	0.3	-1.7	-1.6	-1.8
Taking other prescription medications	0.5	0.8	2.3	-1.1	0.3	-1.5	-0.5	-0.6
Impedance of leg (left)	0.5	2.5	4.4	-2.1	0.6	-1.6	-1.6	-1.6
Mouth/teeth dental problems	0.5	0.7	2.0	0.4	-1.1	-0.2	0.3	1.4
Medication: Ramipril	0.5	0.7	2.1	-0.4	-1.4	-1.0	-0.3	0.1
Lung cancer (father)	0.5	0.6	1.5	0.4	1.2	0.7	0.7	0.5
Exposure to tobacco smoke at home	0.5	0.5	1.7	1.3	0.1	0.7	0.3	-0.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.4	0.9	0.5	1.2	0.9	0.6
High blood pressure (siblings)	0.5	0.7	1.5	1.2	0.4	0.3	1.0	0.9
Shortness of breath walking on level ground	0.5	0.6	1.9	0.5	-0.6	0.4	0.7	1.4
Eye problems/disorders: None of the above	0.5	0.6	1.1	0.1	-1.0	-0.7	-0.9	-0.8
Heart disease (mother)	0.5	0.6	2.6	0.1	1.6	-0.1	0.3	0.3
Long-standing illness, disability or infirmity	0.5	0.8	2.2	0.6	1.5	-0.2	1.0	0.5
Breast cancer (self-reported)	0.5	0.6	1.0	-0.9	-0.0	-0.7	-0.8	-1.0
Whole body water mass	0.5	3.1	9.6	-0.8	-3.1	-1.0	-1.7	-1.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.1	0.0	-0.9	-0.9	-0.5	-1.1
Medication: Paracetamol	0.5	0.7	1.1	-0.8	-0.9	0.8	-0.7	-1.0
Basal metabolic rate	0.5	2.6	8.3	-0.6	-2.9	-1.0	-1.6	-1.0
Alzheimer’s Disease (including proxy)	0.4	0.5	1.6	-0.2	-1.3	-0.5	-0.7	-0.5
Irritable Bowel Disease (IBD)	0.4	0.8	1.7	-1.3	0.5	-0.9	-0.7	-1.0
Fasting Glucose	0.4	0.5	1.0	0.6	0.3	1.0	0.7	0.8
Medication: Co-codamol	0.4	0.5	1.0	-1.0	-0.4	-0.6	-0.6	-0.8
Townsend deprivation index at recruitment	0.4	0.6	1.7	-0.8	0.0	0.4	-0.8	-1.3
Hair/balding pattern: Pattern 2	0.4	0.5	1.4	-0.5	-1.2	-0.2	-0.5	-0.6
Diabetes (self-reported)	0.4	0.5	2.5	-0.4	0.0	-1.6	0.1	-0.2
Arm fat percentage (right)	0.4	1.5	3.9	2.0	0.4	0.7	1.3	1.2
Tense / ‘highly strung’	0.4	0.7	1.3	-0.9	0.1	-0.8	-0.7	-1.2
Medication: Paracetamol	0.4	0.7	3.2	0.1	-0.1	1.8	0.4	-0.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.9	0.3	1.4	1.2	0.1	-0.2
Gout (self-reported)	0.4	0.6	1.7	-0.4	-0.9	-1.3	-0.6	-0.1
Medication: Aspirin	0.4	0.5	2.1	-0.3	-0.5	-1.5	-0.3	-0.1
Smoking status: Previous	0.4	0.6	1.7	0.6	-0.4	1.3	0.9	0.4
Osteoarthritis (self-reported)	0.4	0.5	1.1	0.3	0.6	1.0	1.1	0.2
Ever taken oral contraceptive pill	0.4	0.4	1.2	-1.1	0.1	-0.7	-0.7	-0.2
Commuting to job workplace: Public transport	0.4	0.5	1.6	-0.3	-0.3	0.7	-0.3	-1.3
Medication: Atorvastatin	0.4	0.5	0.7	0.8	0.1	-0.8	0.6	0.9
Irritability	0.4	0.7	1.6	-1.0	-0.6	-0.1	-0.6	-1.3
Age started oral contraceptive pill	0.4	0.5	2.1	0.3	1.4	0.6	0.1	-0.4
Basal cell carcinoma (self-reported)	0.4	0.5	0.9	0.1	0.5	1.0	0.8	0.7
Impedance of whole body	0.4	2.1	3.8	-2.0	1.3	-0.9	-1.2	-1.7
Blood Platelet Count	0.3	3.2	5.4	1.8	0.4	2.3	2.2	1.4
Diabetes (mother)	0.3	0.4	1.5	-1.2	0.1	-0.5	-0.4	0.3
Average weekly fortified wine intake	0.3	0.3	0.7	0.8	-0.5	-0.3	0.3	0.8
Relative age voice broke	0.3	0.4	0.8	0.8	-0.6	0.2	0.4	0.9
Serious illness, injury or assault to yourself	0.3	0.4	1.0	-1.0	-0.5	-0.6	-0.2	-0.4
Leg predicted mass (left)	0.3	1.4	5.4	0.1	-2.3	-0.1	-1.0	-0.6
Number of incorrect matches in round	0.3	0.5	0.8	0.5	0.5	0.9	0.9	0.6
Medication: Simvastatin	0.3	0.5	1.7	-0.9	-0.1	-1.3	-0.1	0.1
Illnesses of siblings	0.3	0.4	0.8	0.1	0.7	0.9	0.5	0.6
Weight	0.3	1.3	4.4	-0.0	-2.1	-0.9	-1.0	-0.6
Impedance of arm (right)	0.3	1.2	5.1	-0.4	2.3	0.8	0.4	-0.3
Hair/balding pattern: Pattern 3	0.3	0.5	0.9	-0.9	0.2	-0.0	-0.8	-0.9
Depression (self-reported)	0.3	0.3	1.3	1.1	-0.3	0.4	0.2	-0.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.1	-0.8	0.6	-0.4	-0.6	-1.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.1	-0.7	-0.3	-1.1	-0.3	-0.4
Knee pain experienced in last month	0.3	0.5	0.7	-0.8	-0.3	-0.8	-0.8	-0.8
Hypertension (Self-reported)	0.3	0.7	2.5	-0.5	-1.6	-0.8	-0.0	0.2
Arm fat percentage (left)	0.3	1.3	3.7	1.9	0.2	0.6	1.2	1.0
Diabetes diagnosed by doctor	0.3	0.5	2.3	-0.5	0.0	-1.5	-0.1	-0.2
Qualifications: nursing, teaching	0.3	0.5	1.3	0.8	1.1	0.7	0.2	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.2	0.4	-1.1	-0.4	-0.6	-0.7
Mineral and other dietary supplements	0.3	0.3	0.9	0.0	-0.6	-1.0	0.3	0.5
Asthma (self-reported)	0.3	0.6	1.2	-0.7	-0.3	-0.8	-0.7	-1.1
Osteoporosis (self-reported)	0.3	0.4	0.8	-0.9	0.3	0.8	0.4	0.4
Smoking status: Current	0.3	0.5	0.8	0.2	0.7	0.9	0.9	0.7
Medication: Blood pressure	0.3	0.6	1.1	-1.0	-0.9	-1.0	-0.4	-0.3
High cholesterol (Self-reported)	0.3	0.5	1.8	0.1	-0.6	-1.3	0.3	0.5
Alcohol drinker status: Never	0.3	0.4	0.8	0.9	0.9	0.3	0.2	-0.6
Risk taking	0.3	0.4	1.0	-1.0	-0.7	-0.1	-0.5	-0.2
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.3	0.1	1.5	1.2	-0.3	-0.9
Alzheimer’s Disease (in mother)	0.2	0.2	0.6	0.8	0.1	0.1	0.4	0.7
Alzheimer’s Disease (in father)	0.2	0.2	0.7	-0.1	-0.9	0.1	-0.2	-0.4
Crohns Disease (2017)	0.2	0.5	1.3	0.4	0.7	0.3	1.1	0.8
Age at First Birth	0.2	0.3	1.2	-0.2	0.2	-1.1	-0.2	-0.1
BMI	0.2	1.1	2.2	1.5	-1.1	-0.6	0.6	1.1
Allergy or Eczema	0.2	0.5	1.5	-0.2	-1.2	-0.8	-0.5	-0.1
Cardiovascular Disease	0.2	0.5	1.9	-0.1	-1.4	-0.7	-0.2	-0.2
Hypothyroidism (self reported)	0.2	0.6	1.0	-0.8	-0.0	-0.7	-0.8	-1.0
Hearing difficulty/problems: Yes	0.2	0.3	0.9	1.0	-0.7	0.3	0.3	0.1
Medication: Metformin	0.2	0.3	0.5	-0.4	-0.5	-0.7	0.4	0.6
Pack years adult smoking proportion	0.2	0.3	0.9	-0.4	1.0	-0.2	-0.2	-0.5
Leg fat-free mass (left)	0.2	1.3	5.2	0.2	-2.3	-0.1	-0.9	-0.6
High blood pressure	0.2	0.6	2.0	-0.0	-1.4	-0.5	0.4	0.8
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	0.4	0.3	-0.7	0.3	0.6
Medication: Levothyroxine sodium	0.2	0.3	0.7	-0.5	0.8	-0.5	-0.1	-0.4
Body mass index (BMI)	0.2	1.0	2.7	1.6	-0.7	0.2	0.9	1.0
Waist circumference	0.2	0.7	1.8	0.1	-1.3	-1.2	-0.4	0.0
Past tobacco smoking	0.2	0.4	1.3	0.1	0.6	-1.1	-0.6	-0.2
Hearing difficulty/problems with background noise	0.2	0.3	1.2	0.6	-1.1	0.3	0.2	0.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.1	0.3	-1.0	0.4	-0.3	-0.2
Alcohol intake versus 10 years previously	0.2	0.4	1.0	-0.4	1.0	-0.5	-0.5	-0.4
Noisy workplace	0.2	0.2	0.4	-0.5	0.4	-0.6	-0.6	-0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.8	0.1	1.3	0.3	0.3	0.2
Asthma	0.2	0.4	0.9	-0.6	-0.2	-0.6	-0.5	-0.9
Impedance of arm (left)	0.2	0.9	2.9	-0.8	1.7	0.1	-0.3	-1.0
Birth weight of first child	0.2	0.3	0.7	-0.1	0.4	-0.3	0.7	0.8
Forced vital capacity (FVC), Best measure	0.2	0.8	1.6	-1.3	-0.6	-0.1	-1.1	-1.0
Leg fat percentage (right)	0.2	0.6	2.0	1.4	-0.5	-0.5	0.5	0.5
Age at first live birth	0.2	0.3	0.9	-0.9	0.1	0.5	-0.6	-0.6
Pulse wave peak to peak time	0.2	0.2	0.8	-0.9	-0.3	-0.3	-0.4	-0.2
Health satisfaction	0.2	0.3	0.5	-0.6	-0.1	-0.6	-0.3	-0.7
Mean time to correctly identify matches	0.2	0.3	0.6	0.1	0.8	0.0	0.7	0.6
Leg fat mass (right)	0.2	0.7	2.2	1.5	-0.9	-0.0	0.4	0.4
Alcohol intake frequency.	0.2	0.5	1.1	0.5	1.0	0.1	-0.4	-1.1
Had major operations	0.2	0.2	0.6	-0.3	0.8	-0.2	0.6	0.3
Age at last live birth	0.2	0.3	0.7	-0.8	0.3	0.4	-0.5	-0.7
Supplements: Vitamin C	0.2	0.2	0.9	0.1	0.1	1.0	0.0	-0.0
Leg fat-free mass (right)	0.2	1.2	4.9	-0.1	-2.2	-0.1	-0.9	-0.5
Ever had bowel cancer screening	0.2	0.3	1.0	-0.1	-0.3	-1.0	-0.6	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	0.0	0.5	0.6	-0.3	-0.5
Leg predicted mass (right)	0.2	1.2	4.7	-0.1	-2.2	-0.1	-1.0	-0.6
Medication: Bendroflumethiazide	0.2	0.3	1.3	0.0	0.1	-1.2	0.3	0.3
Ever smoked	0.2	0.3	1.3	-1.1	-0.1	0.1	-0.1	-0.5
Leg fat percentage (left)	0.2	0.6	2.0	1.4	-0.2	-0.3	0.6	0.7
Pack years of smoking	0.2	0.3	1.1	-0.3	1.1	-0.1	-0.1	-0.3
Major Depression (MDD)	0.1	0.1	0.2	-0.1	-0.1	-0.5	-0.4	-0.4
Reaction Time	0.1	0.2	0.6	-0.2	0.8	-0.3	0.1	0.2
Crohns Disease (2012)	0.1	0.1	0.3	-0.1	0.2	-0.4	0.5	0.4
Blood Red Count	0.1	0.7	1.1	-0.9	-0.8	-0.6	-0.8	-1.1
Respiratory disease	0.1	0.2	0.3	-0.4	-0.5	0.1	-0.2	-0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.3	1.1	-0.2	-0.1	-1.1	-0.3	-0.2
Average weekly spirits intake	0.1	0.2	0.5	-0.2	0.7	-0.6	-0.1	-0.1
Systolic blood pressure, automated reading	0.1	0.3	0.7	0.3	-0.8	0.1	0.5	0.6
Trunk fat percentage	0.1	0.2	1.0	1.0	-0.2	-0.0	0.4	0.3
Age when periods started (menarche)	0.1	0.1	0.4	0.6	-0.2	0.3	0.3	0.2
Trunk fat mass	0.1	0.4	1.3	0.7	-1.1	-0.5	-0.2	-0.1
Alcohol usually taken with meals	0.1	0.2	0.4	-0.6	-0.5	-0.4	-0.5	0.2
Forced vital capacity (FVC)	0.1	0.3	0.9	-0.4	-0.5	1.0	0.1	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.5	0.0	-0.6	0.1	-0.2	-0.7
Pulse wave Arterial Stiffness index	0.1	0.1	0.5	0.7	0.3	0.2	0.2	-0.1
Arm fat mass (right)	0.1	0.6	1.9	1.4	-0.6	0.1	0.5	0.5
Medication: Amlodipine	0.1	0.1	0.3	-0.2	0.0	0.5	0.4	0.5
Birth weight	0.1	0.2	0.4	0.3	-0.6	0.4	0.5	0.6
Body fat percentage	0.1	0.5	1.9	1.4	-0.0	0.0	0.6	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.6	0.5	0.1	0.2	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.5	-0.2	0.7	0.1	0.3	0.1
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.1	-0.5	-0.0	0.2	0.3
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	0.5	0.2	0.3	0.3	0.6
Neck or shoulder pain in last month	0.1	0.1	0.3	0.1	-0.5	0.2	-0.1	-0.3
Medication: Ibuprofen	0.1	0.1	0.2	-0.3	0.1	0.4	-0.1	-0.4
Whole body fat mass	0.1	0.4	1.0	0.9	-1.0	-0.4	-0.1	-0.0
Eye problems/disorders: Cataract	0.1	0.1	0.2	-0.2	0.4	0.2	0.1	0.4
Arm fat mass (left)	0.1	0.5	1.7	1.3	-0.7	0.1	0.4	0.5
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.3	-0.1	-0.4	-0.3	-0.4
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	-0.4	-0.1	0.0	0.6	0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	-0.1	0.3	0.4	-0.5	-0.6
Illnesses of father: High blood pressure	0.1	0.1	0.5	-0.2	0.0	-0.7	-0.1	-0.3
Diastolic blood pressure, automated reading	0.1	0.4	0.8	-0.6	-0.9	-0.9	-0.1	0.3
Ever depressed for a whole week	0.1	0.2	0.5	0.5	-0.7	0.5	0.0	0.2
Leg fat mass (left)	0.1	0.6	2.0	1.4	-0.7	-0.0	0.3	0.5
Breast Cancer	0.0	0.1	0.2	0.1	0.5	0.2	-0.3	-0.5
Rheumatoid Arthritis	0.0	0.0	0.2	-0.2	-0.2	0.4	0.1	0.0
Relative age of first facial hair	0.0	0.0	0.1	-0.0	-0.3	0.3	-0.1	0.1
Diabetes (father)	0.0	0.0	0.1	-0.2	0.1	-0.1	0.1	0.3
High blood pressure (mother)	0.0	0.0	0.1	-0.1	-0.4	0.2	-0.1	-0.1
Pain all over the body in last month	0.0	0.0	0.2	-0.1	0.1	-0.1	0.1	0.4
Mouth/teeth dental problems: Loose teeth	0.0	0.1	0.2	0.2	0.0	-0.1	0.1	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.1	0.1	-0.3	0.1	0.3	0.3	0.1
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	-0.1	-0.3	0.1	-0.0	0.3

Hub : Genes

EIF3E

Models

Trait associations