Hub : Genes

EMC2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.1950	0.088	5.7e-03	0.165	NA	0.118	NA	0.141	1.7e-05	NA	3.0e-04	NA	7.7e-05
2	GTEx	Brain Cerebellum	0.2940	0.081	6.7e-07	0.197	NA	0.156	NA	0.198	1.8e-06	NA	2.4e-05	NA	1.7e-06
3	GTEx	Cells Transformed fibroblasts	0.1190	0.057	7.5e-03	-0.002	NA	0.042	NA	0.000	4.6e-01	NA	4.0e-04	NA	3.2e-01
4	GTEx	Esophagus Gastroesophageal Junction	0.0920	0.043	7.8e-03	0.098	NA	0.034	NA	-0.004	2.1e-04	NA	2.2e-02	NA	4.9e-01
5	GTEx	Esophagus Mucosa	0.1910	0.049	4.9e-09	0.205	NA	0.198	NA	0.198	9.5e-14	NA	2.5e-13	NA	2.6e-13
6	GTEx	Esophagus Muscularis	0.2490	0.068	2.8e-07	0.154	NA	0.127	NA	0.145	1.2e-09	NA	4.1e-08	NA	4.3e-09
7	GTEx	Muscle Skeletal	0.0465	0.021	3.0e-03	0.039	NA	0.009	NA	0.022	8.9e-05	NA	4.1e-02	NA	2.6e-03
8	GTEx	Skin Not Sun Exposed Suprapubic	0.0970	0.043	1.3e-03	0.084	NA	0.042	NA	0.060	2.5e-05	NA	2.3e-03	NA	3.4e-04
9	GTEx	Skin Sun Exposed Lower leg	0.1200	0.044	8.9e-05	0.082	NA	0.040	NA	0.062	2.8e-07	NA	2.6e-04	NA	7.0e-06
10	GTEx	Stomach	0.1520	0.071	1.7e-03	0.034	NA	0.025	NA	0.051	9.2e-03	NA	2.3e-02	NA	1.8e-03
11	GTEx	Testis	0.2790	0.095	1.9e-04	0.060	NA	0.027	NA	0.012	1.2e-03	NA	2.3e-02	NA	9.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.5	0.9	2.9	0.2	-1.1	0.1	-1.3	0.3	-0.4	1.7	0.7	0.4	-0.2	1.7
Bipolar Disorder or Schizophrenia	1.2	3.0	5.2	2.2	1.7	-0.7	1.0	-2.2	2.3	-0.2	-1.7	-2.1	1.7	2.1
Depressed Affect (Nagel 2018)	1.3	2.7	4.3	2.1	1.6	-1.2	1.6	-1.7	1.7	-1.8	-1.9	-1.5	1.9	0.9
Depression (Nagel 2018)	0.9	1.4	3.4	1.4	0.6	-1.8	-0.2	-1.4	1.4	0.2	-1.4	-1.4	0.8	1.2
Intelligence (Savage-Jansen 2018)	0.7	2.3	6.5	-0.3	-1.8	-0.1	-2.4	0.6	-0.7	2.5	0.9	0.7	-1.2	2.3
Neuroticism (Nagel 2018)	0.7	1.6	3.5	1.9	1.3	-1.2	1.1	-1.1	1.3	-1.1	-1.3	-1.1	1.5	0.5
Schizophrenia (2018)	3.0	6.3	10.6	2.6	3.0	-1.0	2.3	-3.1	3.3	-1.7	-2.7	-3.0	2.4	1.3
Schizophrenia vs Biploar Disorder	0.9	1.2	4.1	0.0	1.3	0.0	1.9	0.1	0.1	-2.0	-0.1	0.2	0.5	-2.0
Worry (Nagel 2018)	0.6	1.2	3.0	1.7	1.1	-0.8	0.9	-0.9	1.2	-0.7	-1.0	-1.1	1.4	0.6
Alzheimer’s Disease (in mother)	0.2	0.2	0.9	0.2	0.3	-0.9	0.3	-0.5	0.3	0.1	-0.9	-0.4	0.4	-0.1
Alzheimer’s Disease (in father)	0.2	0.2	0.5	-0.3	-0.3	-0.6	-0.4	0.1	0.1	0.7	0.5	0.1	-0.7	0.3
Alzheimer’s Disease (including proxy)	0.1	0.2	0.8	-0.7	0.1	-0.9	0.2	-0.2	0.4	0.2	-0.1	-0.3	-0.2	0.3
Crohns Disease (2017)	0.2	0.5	3.7	0.8	-0.4	-1.9	-0.4	-0.2	-0.3	0.3	-0.1	-0.0	0.3	0.6
Irritable Bowel Disease (IBD)	0.9	2.2	6.9	1.2	1.4	-2.6	0.9	-1.7	1.6	-0.6	-1.8	-1.7	0.9	0.8
Ulcerative Colitis (UC)	1.5	2.8	4.6	1.1	2.0	-2.0	1.5	-1.9	2.1	-1.1	-2.1	-2.0	1.1	0.4
Major Depression (MDD)	1.2	1.5	2.8	1.3	1.5	0.5	1.5	-1.2	1.0	-0.8	-1.4	-1.1	1.7	-0.6
Reaction Time	0.4	0.7	2.3	-0.6	1.3	-0.7	1.5	-0.6	0.7	-0.7	-1.1	-0.7	0.4	0.5
Verbal and Numeric Reasoning (VNR)	1.6	3.8	8.0	-0.9	-2.5	0.3	-2.8	1.6	-1.7	2.7	2.0	1.6	-2.4	1.5
Breast Cancer	0.2	0.4	1.1	1.0	0.6	-0.3	0.2	-0.5	0.6	-0.3	-0.5	-0.7	1.0	0.6
Ovarian Cancer	0.6	0.8	2.2	1.0	0.8	-0.4	1.4	-0.0	0.0	-1.5	-0.9	-0.0	1.3	-0.1
Prostate Cancer	0.2	0.3	1.9	-0.4	-0.2	1.4	-0.4	0.1	-0.3	0.7	-0.0	0.1	0.5	0.3
Age at First Birth	0.2	0.3	0.6	0.7	0.6	0.7	0.7	-0.2	0.4	-0.7	-0.5	-0.5	0.4	-0.8
Bipolar Disorder (2011)	0.7	0.7	3.0	0.1	-1.0	1.1	-1.1	0.3	-0.5	1.7	0.7	0.4	-0.0	0.1
Body Mass Index (BMI) (2010)	1.0	1.4	3.0	-0.2	0.1	1.7	1.3	1.3	-1.0	-1.4	0.7	1.2	1.3	-1.5
Coronary Artery Disease (CAD)	0.5	0.6	2.2	-0.3	0.4	0.3	1.5	0.3	-0.5	-1.1	-0.4	0.4	1.4	-0.2
Crohns Disease (2012)	0.2	0.3	2.4	0.6	-0.1	-1.6	0.2	-0.1	-0.4	-0.2	-0.0	0.0	0.5	-0.1
Mean Putamen Volume	2.6	2.9	6.7	1.0	2.6	-1.3	2.1	-2.0	2.3	-0.8	-1.8	-2.2	0.8	-0.2
Fasting Glucose	1.1	1.4	3.1	-1.1	-1.8	0.3	-1.2	1.4	-1.2	0.5	1.2	1.3	-1.4	0.4
HbA1C	1.1	1.2	2.2	0.6	1.5	-1.1	0.8	-1.2	1.3	-1.3	-1.2	-1.0	-0.0	-1.3
HDL Cholesterol	0.6	1.0	4.8	1.1	-0.2	-0.4	-0.9	0.2	1.4	0.6	0.9	-0.3	-0.6	2.2
LDL Cholesterol	0.5	0.8	2.7	-1.6	-0.2	1.3	0.6	0.7	-1.1	-0.3	0.1	0.7	0.5	-1.5
Lupus	1.2	1.8	4.5	-2.1	-1.6	0.5	-1.3	1.4	-1.6	1.6	1.2	1.3	-0.5	0.8
Neuroticism (2016)	0.6	0.9	5.3	-0.2	1.0	0.3	1.1	-0.2	0.0	-1.0	-0.6	-0.1	-0.6	-2.3
Primary Biliary Cirrhosis	1.4	2.0	4.3	1.1	1.4	-1.5	1.1	-1.8	2.1	-0.6	-1.6	-1.8	1.5	0.0
Rheumatoid Arthritis	0.5	0.7	2.1	-0.9	-0.9	-1.0	-0.8	0.6	-0.5	1.5	0.8	0.6	-0.9	0.8
Schizophrenia (2014)	3.5	7.8	12.0	3.1	3.4	-0.0	2.8	-3.4	3.5	-2.1	-3.1	-3.2	2.7	1.1
Triglycerides	0.4	0.6	1.6	-1.0	0.8	-0.4	1.1	-0.9	-0.2	-0.7	-1.3	-0.6	0.6	-0.5
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.6	-1.1	-0.8	1.2	-0.5	1.0	-1.3	0.7	0.9	1.1	-0.1	-0.6
Ulcerative Colitis	1.7	2.5	4.5	1.5	1.9	-1.7	1.6	-1.6	2.1	-1.3	-1.8	-1.7	1.2	-0.2
Blood Eosinophil Count	0.1	0.4	1.7	-0.7	-0.5	-0.7	-0.4	0.4	-0.6	1.3	0.8	0.5	0.4	-0.1
Blood Platelet Count	0.1	0.8	1.6	1.1	-0.8	-0.4	-1.2	0.3	-0.4	1.2	0.8	0.4	0.7	1.3
Blood Red Count	0.1	1.4	3.1	1.1	1.8	1.1	1.6	-1.2	1.4	-0.5	-0.9	-1.2	1.3	0.1
Blood White Count	1.0	7.3	11.7	-3.4	-3.3	1.6	-2.6	3.2	-2.8	2.3	3.4	3.2	-1.6	-0.9
Heel T-Score	3.3	26.4	46.8	-5.2	-6.3	1.2	-4.8	6.3	-6.8	5.8	5.8	6.3	-2.5	-0.3
BMI	1.0	6.0	9.8	-2.3	-3.0	1.1	-2.3	3.1	-3.1	2.1	2.9	3.1	-1.8	0.3
Height	0.2	3.8	8.5	-0.7	2.9	-0.5	2.1	-2.3	2.9	-1.8	-2.1	-2.6	-0.5	0.0
Waist Hip Ratio (WHR)	0.1	0.5	1.6	-1.3	-0.8	-0.1	-0.6	0.5	-1.1	-0.3	0.2	0.6	-0.9	-0.7
Systolic Blood Pressure	0.2	0.8	3.8	-0.0	0.5	-0.4	0.8	-0.4	0.7	-1.9	-0.5	-0.4	0.4	-1.7
Smoking Status	0.6	1.4	4.9	-0.4	-1.7	0.2	-2.2	0.4	-0.2	1.2	0.7	0.5	-2.2	-0.2
Allergy or Eczema	0.4	1.1	4.0	-1.3	-1.0	-0.9	-1.0	1.1	-0.8	0.6	0.8	0.9	-2.0	-0.4
Cardiovascular Disease	0.1	0.4	2.2	-0.2	0.4	-0.6	0.5	-0.3	0.4	-0.7	-0.2	-0.3	0.3	-1.5
Hypothyroidism (self reported)	0.1	0.3	1.2	1.1	0.6	-0.3	0.4	-0.4	0.5	-0.6	-0.5	-0.3	0.1	-0.1
Respiratory disease	0.3	0.7	2.0	1.2	0.4	-1.1	-0.1	-0.9	1.4	-0.3	-0.8	-1.1	-0.6	0.3
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.1	0.5	0.3	1.1	0.6	0.5	-0.1	-0.6	0.8	0.4	0.8	-0.3
Lung FEV1/FVC ratio	3.5	17.8	53.9	-0.6	-5.1	-1.3	-6.7	1.3	-2.2	7.3	2.9	1.7	-2.2	6.8
Lung FVC	0.4	1.9	5.4	-0.3	-1.1	-1.4	-2.1	-0.7	0.6	1.8	-0.4	-0.8	-1.5	2.3
Neuroticism	0.5	1.2	4.1	2.0	0.9	-0.8	0.8	-0.9	1.2	-1.0	-1.2	-1.0	0.9	0.6
Chronotype (morning person)	1.1	2.6	7.7	-1.2	-2.0	-0.5	-2.8	1.0	-1.1	2.3	1.6	1.1	-1.9	0.2
Hair Pigment	0.6	16.6	87.2	1.2	-2.7	-1.8	-5.1	-1.4	-0.0	7.3	0.1	-0.8	1.3	9.3
Tanning	0.3	3.7	6.1	-2.0	-2.3	0.5	-2.5	2.0	-2.2	1.9	2.0	2.0	-1.7	1.4
Hand grip strength (left)	2.6	6.8	12.2	-2.6	-2.5	2.7	-2.3	3.0	-2.7	1.6	3.0	2.8	-3.5	0.8
Number of treatments/medications taken	1.2	2.2	3.9	1.6	1.5	-1.0	1.6	-1.6	1.9	-2.0	-1.4	-1.6	1.2	-0.4
Average weekly spirits intake	0.2	0.3	1.2	-0.0	-0.2	-1.1	0.4	0.5	-0.5	-0.2	0.2	0.5	0.7	-0.2
Sensitivity / hurt feelings	0.2	0.4	1.2	0.3	1.1	-0.6	1.0	-0.6	0.7	-0.3	-0.6	-0.6	0.1	-0.2
Frequency of depressed mood in last 2 weeks	1.6	2.3	6.0	1.0	1.4	-1.6	0.6	-1.9	2.0	-0.4	-2.5	-2.2	-0.0	0.5
Hearing difficulty/problems: Yes	0.1	0.1	0.5	0.3	-0.2	-0.5	-0.5	-0.1	0.0	0.1	-0.7	-0.2	0.1	-0.3
Relative age of first facial hair	0.2	0.4	1.8	-1.3	-0.2	-0.7	-0.2	0.1	-0.3	0.3	0.0	0.1	-1.2	-0.3
Other serious medical condition/disability diagnosed by doctor	1.4	1.9	3.2	1.8	1.5	-0.9	1.0	-1.8	1.8	-0.9	-1.3	-1.7	1.2	-0.3
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.3	0.9	0.7	-0.4	0.4	-0.9	1.1	-0.4	-0.6	-0.8	0.1	-0.3
Ever had hysterectomy (womb removed)	0.5	0.5	1.6	-1.3	-0.3	1.0	-0.2	0.4	-0.4	0.1	0.4	0.3	-1.0	-1.2
Systolic blood pressure, automated reading	0.2	0.6	1.8	-0.7	-0.8	0.8	-0.6	0.8	-0.6	0.4	1.4	0.9	-0.4	-0.9
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	3.0	0.2	0.8	0.8	1.5	0.1	0.2	-1.7	0.1	0.1	1.6	-0.3
Angina	0.8	1.0	2.7	-0.8	-0.5	0.2	0.3	1.6	-1.4	-0.3	1.2	1.4	0.0	-1.4
Medication for hormone replacement therapy	1.0	1.1	2.4	1.5	1.2	-0.2	1.3	-0.8	0.9	-1.4	-0.8	-0.7	1.3	-0.5
Vitamin and mineral supplements	0.2	0.3	0.7	-0.4	-0.3	0.5	-0.2	0.6	-0.5	-0.2	0.8	0.6	-0.6	-0.8
Supplements: Zinc	2.2	2.4	4.6	-1.3	-1.6	1.4	-1.4	1.7	-1.6	2.2	1.8	1.6	-1.1	0.8
Medication: Co-codamol	0.4	0.5	2.1	0.1	0.5	-1.5	0.3	-0.9	1.0	-0.3	-0.7	-0.9	-0.3	-0.2
Medication: Metformin	0.5	0.7	1.9	0.1	0.6	0.6	1.0	0.2	-0.0	-1.1	0.7	0.3	1.3	-1.4
Diabetes (father)	1.4	1.8	9.1	-0.8	-0.7	3.0	-0.4	1.4	-1.2	-0.2	1.6	1.5	-1.1	-0.2
Diabetes (mother)	0.3	0.4	1.9	-0.4	0.1	1.4	0.5	0.4	-0.6	0.1	0.2	0.3	1.1	-0.2
Severe depression (siblings)	0.7	0.7	1.8	1.2	1.1	1.0	1.4	0.1	0.2	-1.3	-0.2	-0.0	1.0	-0.4
Pack years adult smoking proportion	0.4	0.6	3.1	0.8	0.0	-1.0	-0.3	-0.5	0.4	0.1	-0.3	-0.4	0.7	1.8
Impedance of leg (right)	1.4	6.6	14.9	2.4	3.3	0.6	3.6	-2.0	1.9	-3.2	-2.3	-1.8	3.9	-0.4
Leg fat-free mass (left)	0.5	2.5	6.0	-1.6	-1.7	-0.3	-2.5	0.7	-0.6	2.4	1.1	0.5	-2.3	1.5
Trunk fat percentage	0.3	1.4	2.5	-0.7	-1.3	-0.3	-1.4	1.1	-1.2	1.6	1.4	1.2	-0.3	1.6
Hand grip strength (right)	2.1	5.6	8.9	-2.6	-2.3	2.3	-2.2	2.7	-2.3	1.8	2.7	2.4	-3.0	1.3
Townsend deprivation index at recruitment	2.9	4.1	8.7	1.6	1.9	-1.9	0.9	-3.0	2.8	-1.4	-2.3	-2.6	0.6	-1.6
Current tobacco smoking	0.1	0.1	0.4	0.3	0.1	-0.2	-0.1	-0.6	0.4	-0.2	-0.7	-0.4	0.2	0.1
Average weekly fortified wine intake	2.1	2.5	4.3	-2.0	-1.7	-0.2	-1.7	1.7	-1.6	1.6	2.1	1.6	-1.6	-0.6
Maternal smoking around birth	0.2	0.3	1.2	-0.4	-0.2	-0.6	-0.8	-0.6	0.2	0.9	-0.4	-0.2	-1.1	0.3
Fed-up feelings	1.5	2.7	5.8	1.6	1.6	-0.7	1.0	-2.2	2.0	-1.3	-2.4	-2.1	1.3	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	5.8	1.6	1.2	-2.4	0.1	-2.2	2.1	-0.3	-2.2	-2.2	0.2	1.0
Relative age voice broke	0.4	0.6	1.7	-1.3	-0.2	1.0	0.1	0.8	-1.0	0.5	0.3	0.7	-0.6	-0.7
Taking other prescription medications	0.5	0.8	2.6	0.1	-0.2	1.3	0.5	1.0	-0.6	-1.6	0.6	0.9	0.0	-1.2
Age when periods started (menarche)	0.0	0.1	0.6	0.3	-0.3	0.1	-0.2	0.1	-0.1	0.4	0.2	0.1	0.1	0.8
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.5	-0.1	0.2	-0.7	-0.1	-0.6	0.5	0.2	-0.1	-0.6	-0.3	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.6	6.9	-1.9	-2.4	-0.2	-2.6	1.9	-2.1	2.6	1.9	1.8	-1.1	0.0
Tinnitus: Yes, but not now, but have in the past	1.4	1.4	3.0	-0.2	1.7	-1.1	1.5	-1.0	1.5	-1.5	-1.2	-1.2	0.5	-0.8
Qualifications: CSEs or equivalent	1.3	1.7	2.8	0.8	1.6	0.6	1.5	-1.3	1.7	-1.7	-1.3	-1.4	1.4	-0.4
Serious illness, injury or assault to yourself	0.2	0.2	0.5	0.5	0.4	-0.0	0.2	-0.3	0.6	-0.6	-0.2	-0.4	0.3	0.7
High blood pressure	0.3	0.8	5.5	-1.2	-0.4	-0.4	0.1	0.5	-0.4	-0.5	0.5	0.5	-0.3	-2.3
Hayfever, allergic rhinitis or eczema	0.4	0.8	3.4	-0.9	-0.7	-0.6	-0.6	1.0	-0.5	-0.0	0.8	0.8	-1.8	-1.1
Multivitamins +/- minerals	0.2	0.3	0.7	0.2	0.3	-0.8	-0.0	-0.6	0.3	0.6	-0.6	-0.5	0.1	0.8
Stomach or abdominal pain in last month	1.2	1.4	7.8	-0.7	0.9	0.3	1.2	-0.0	0.3	-2.0	-1.1	-0.5	-0.2	-2.8
Supplements: Glucosamine	0.5	0.6	1.1	0.7	-0.1	-0.8	-0.8	-1.0	0.9	0.9	-0.3	-0.9	-0.4	1.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.7	-0.1	-0.6	0.1	-0.1	1.2	-1.1	-0.5	0.5	1.1	-0.4	-1.3
Medication: Atenolol	0.2	0.3	0.9	0.7	0.5	0.3	0.7	0.2	0.4	-1.0	0.4	0.2	0.7	-0.2
Medication: Levothyroxine sodium	0.3	0.5	1.8	0.8	0.4	-1.3	-0.0	-0.8	0.6	-0.6	-0.8	-0.6	-0.3	-0.3
Sitting height	0.2	1.7	4.8	0.7	2.2	1.0	1.8	-1.1	1.5	-1.2	-0.8	-1.4	0.0	-1.1
Chronic bronchitis/emphysema (father)	1.1	1.3	6.6	-1.1	-0.7	1.0	-0.1	1.2	-0.9	-0.1	0.9	1.1	-0.5	-2.6
High blood pressure (mother)	0.0	0.1	0.3	-0.2	-0.2	0.3	-0.1	0.0	-0.1	0.2	-0.2	0.0	-0.3	0.6
Body mass index (BMI)	1.1	4.8	8.3	-1.8	-2.8	-0.1	-2.9	2.2	-2.2	2.6	2.5	2.2	-2.1	1.1
Impedance of leg (left)	1.3	6.4	14.9	2.0	3.3	1.1	3.9	-1.8	1.9	-3.4	-2.1	-1.6	3.7	-0.7
Leg predicted mass (left)	0.5	2.4	5.9	-1.6	-1.7	-0.2	-2.4	0.7	-0.6	2.3	1.1	0.5	-2.3	1.5
Trunk fat mass	0.5	1.9	3.9	-1.2	-1.6	-0.2	-1.8	1.3	-1.2	2.0	1.7	1.3	-0.9	1.4
Waist circumference	0.4	1.4	2.1	-1.4	-1.4	-0.3	-1.3	1.3	-1.3	1.4	1.5	1.2	-0.9	0.2
Number of incorrect matches in round	0.8	1.3	2.6	0.5	-1.6	1.3	-1.1	1.4	-1.1	0.6	1.2	1.3	-0.2	1.5
Past tobacco smoking	1.1	2.1	8.5	-0.0	2.2	1.0	2.9	-0.2	-0.1	-1.2	-0.5	-0.2	2.6	-0.0
Alcohol usually taken with meals	1.6	2.5	9.5	-1.9	-1.5	0.8	-1.2	2.0	-1.5	0.3	1.2	1.6	-3.1	-0.5
Nervous feelings	0.1	0.1	0.3	0.2	0.2	0.5	0.4	0.3	0.1	0.0	0.4	0.2	0.3	0.6
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	4.4	-0.2	-0.8	-1.9	-1.7	-0.5	0.3	1.8	-0.5	-0.5	-0.9	2.1
Hearing difficulty/problems with background noise	0.1	0.2	1.7	0.0	-0.1	1.3	0.0	0.3	-0.1	-0.1	0.3	0.2	-0.1	-0.2
Hair/balding pattern: Pattern 2	0.3	0.4	1.0	0.5	0.1	-1.0	-0.2	-0.9	1.0	-0.2	-0.7	-0.9	0.3	-0.4
Had menopause	0.2	0.3	1.2	0.4	0.3	1.1	0.3	-0.6	0.6	0.1	-0.3	-0.5	0.5	-0.4
Had other major operations	0.3	0.3	0.9	0.6	-0.7	-0.0	-0.9	0.1	-0.4	0.6	0.1	0.3	-0.7	0.9
Forced vital capacity (FVC)	0.2	0.9	3.0	-1.2	-0.0	0.2	-0.9	-0.8	0.6	1.3	-0.5	-0.8	-1.7	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.7	3.2	-1.2	-1.6	0.2	-1.4	1.5	-1.8	1.5	1.6	1.6	-0.3	-0.5
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.9	-0.0	-1.1	-0.4	-1.7	0.2	-0.2	0.4	-0.1	0.1	-1.5	0.5
Qualifications: None of the above	2.5	5.3	20.2	0.7	2.1	1.0	3.4	-0.1	0.6	-3.8	-0.4	-0.1	2.4	-4.5
Financial difficulties in last 2 years	0.2	0.3	2.3	-0.1	0.2	0.0	0.5	0.0	0.2	-0.7	-0.1	-0.1	0.0	-1.5
Mouth/teeth dental problems	0.9	1.3	5.1	-2.3	-0.5	0.2	-0.3	1.2	-1.5	0.7	0.6	1.2	-1.6	-0.8
Heart attack	1.3	1.7	3.4	-1.3	-0.9	0.9	0.1	1.8	-1.5	-0.8	1.6	1.8	-0.5	-1.6
Allergy	0.2	0.5	1.6	-0.1	-0.3	1.2	-0.2	0.1	-0.8	1.0	0.4	0.3	1.3	1.1
Pain all over the body in last month	0.7	0.7	1.3	-0.0	0.9	-0.9	0.8	-1.0	1.0	-0.4	-0.8	-1.2	0.8	1.0
Diabetes (self-reported)	1.2	1.8	4.1	1.3	1.2	1.5	1.9	0.2	0.1	-2.0	0.6	0.3	1.9	-1.7
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	2.6	0.0	-0.4	1.0	0.2	1.6	-1.1	-0.6	1.5	1.4	-0.8	-1.4
Medication: Ramipril	0.5	0.7	1.5	-0.9	-0.5	0.4	0.2	1.1	-1.2	-0.3	0.6	1.1	0.3	-1.2
Medication: Simvastatin	0.4	0.5	2.8	-0.5	0.5	0.9	0.9	0.4	-0.2	-0.8	0.3	0.4	-0.0	-1.7
Fluid intelligence score	0.6	1.2	3.7	-0.1	-1.2	0.3	-1.9	0.4	-0.4	1.9	0.7	0.4	-1.4	1.3
Illnesses of siblings	0.4	0.6	3.4	-0.2	-0.6	0.2	-0.7	0.4	-0.7	0.9	0.1	0.5	0.2	1.8
Neuroticism score	0.3	0.5	1.0	0.9	1.0	0.1	1.0	-0.6	0.7	-0.9	-0.9	-0.6	0.4	0.2
Weight	0.4	2.0	3.8	-1.5	-1.6	-0.0	-1.9	1.1	-0.9	1.9	1.6	1.0	-1.7	1.1
Impedance of arm (right)	0.8	3.7	6.5	2.5	2.3	-0.8	2.0	-2.2	1.8	-1.7	-2.0	-1.9	2.3	0.6
Arm fat percentage (right)	0.8	3.2	6.1	-1.1	-2.3	-0.6	-2.5	1.6	-1.8	2.5	2.0	1.8	-0.9	1.6
Trunk fat-free mass	0.2	1.3	3.4	-1.8	-1.1	0.6	-1.4	0.7	-0.4	1.1	1.1	0.5	-1.8	0.0
Hip circumference	0.1	0.2	1.0	-0.4	-0.3	-0.4	-0.6	0.3	-0.1	1.0	0.6	0.2	-0.1	0.7
Time employed in main current job	1.1	1.3	4.1	1.2	1.1	0.6	0.6	-1.1	1.4	0.6	-0.4	-1.3	2.0	1.3
Alcohol intake versus 10 years previously	0.8	1.2	2.5	0.6	0.9	-1.6	0.3	-1.6	1.5	0.1	-1.0	-1.4	0.5	1.4
Father’s age at death	2.4	3.2	5.4	-1.2	-1.8	1.9	-1.0	2.3	-2.1	1.7	2.1	2.3	-0.3	1.9
Worrier / anxious feelings	1.3	2.5	4.3	1.6	1.9	-0.9	2.1	-1.4	1.3	-1.8	-1.8	-1.4	1.6	-1.2
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.4	6.3	1.7	1.9	-1.9	1.5	-2.1	2.5	-1.6	-2.3	-2.4	1.1	0.1
Falls in the last year	0.7	0.9	7.1	0.0	-0.2	0.2	0.4	0.6	-0.3	-1.4	-0.0	0.5	-0.5	-2.7
Hair/balding pattern: Pattern 3	0.2	0.4	2.3	0.4	-0.2	0.7	-0.6	-0.3	0.4	0.5	0.4	-0.2	-0.2	1.5
Number of live births	1.1	1.6	3.6	-1.9	-1.6	0.8	-1.5	1.0	-1.0	1.2	1.1	1.1	-1.6	0.1
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	11.8	-1.6	-1.5	-0.6	-2.9	-0.2	-0.1	3.4	0.3	-0.3	-2.6	2.9
Pulse rate	1.2	1.9	5.9	0.4	-1.5	-0.8	-2.4	-0.1	-0.0	2.3	0.5	-0.3	-1.6	2.0
Happiness	0.6	0.7	1.4	1.2	0.8	-0.6	0.6	-0.8	1.0	-0.9	-0.7	-0.7	1.2	0.5
Noisy workplace	0.3	0.4	0.8	-0.3	0.2	0.9	0.8	0.8	-0.6	-0.1	0.8	0.7	0.6	0.5
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.5	0.8	0.2	-0.8	-0.2	-0.6	0.4	0.4	-0.9	-0.7	0.2	1.2
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	7.2	-1.4	-0.6	2.7	0.1	1.8	-1.2	-0.3	1.3	1.5	-1.1	-0.9
Mouth/teeth dental problems: Dentures	1.4	2.4	5.4	2.3	0.7	-0.5	-0.2	-2.2	2.3	0.1	-1.4	-2.2	1.3	1.1
Asthma	1.8	3.6	6.6	2.4	2.1	-1.6	1.2	-2.3	2.6	-1.3	-2.4	-2.4	0.7	0.2
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.6	4.2	1.2	1.0	-2.0	0.3	-1.4	1.0	-0.9	-2.0	-1.4	-0.3	0.7
Medication: Cholesterol lowering	1.8	2.7	5.0	-2.0	-1.5	1.7	-0.8	2.2	-1.9	0.6	2.1	1.9	-0.5	-1.7
Depression (self-reported)	1.4	1.7	7.0	-0.2	-1.8	0.3	-2.3	0.8	-0.8	1.0	0.6	0.8	-2.6	0.3
Medication: Lansoprazole	1.9	2.2	3.5	1.7	1.5	-0.4	1.1	-1.5	1.5	-1.9	-1.4	-1.5	1.2	-1.9
Prospective memory result	0.7	0.9	2.4	-0.2	-1.3	0.9	-1.5	0.5	-0.3	0.3	1.1	0.6	-1.6	0.2
Lung cancer (father)	0.3	0.3	1.3	0.2	-0.1	-1.1	-0.2	-0.7	0.3	0.1	-1.0	-0.6	-0.1	-0.4
Illnesses of mother	0.4	0.5	1.3	0.7	0.5	-1.0	-0.2	-1.2	1.1	0.1	-0.6	-1.0	0.1	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	7.5	-0.7	-0.6	-1.4	-2.0	-1.1	0.7	2.7	-0.5	-1.1	-1.6	2.7
Pulse wave Arterial Stiffness index	0.4	0.4	2.0	0.8	0.0	-1.4	0.0	-0.2	-0.1	-0.0	-0.6	-0.3	0.4	1.2
Impedance of arm (left)	1.1	5.1	7.7	2.7	2.7	-1.4	2.5	-2.4	2.1	-2.0	-2.5	-2.2	2.8	0.6
Arm fat mass (right)	0.7	3.1	6.2	-1.2	-2.2	-0.7	-2.5	1.4	-1.5	2.5	1.8	1.5	-1.2	1.9
Trunk predicted mass	0.2	1.3	3.4	-1.8	-1.1	0.7	-1.4	0.7	-0.3	1.1	1.1	0.4	-1.8	-0.0
Standing height	0.2	2.2	5.3	0.3	2.3	0.5	1.8	-1.7	2.2	-1.2	-1.4	-2.0	0.5	0.2
Length of working week for main job	0.2	0.2	0.5	0.7	0.1	-0.6	-0.3	-0.5	0.3	-0.1	-0.3	-0.4	0.0	-0.6
Exposure to tobacco smoke at home	0.8	0.9	1.8	0.5	0.2	-1.0	-0.4	-1.3	1.2	0.7	-1.1	-1.2	0.8	1.3
Breastfed as a baby	5.4	6.7	11.1	-2.9	-3.1	0.4	-2.7	3.1	-2.7	2.2	3.3	2.9	-2.7	0.3
Tense / ‘highly strung’	0.2	0.3	1.2	0.9	0.4	-0.1	0.2	-0.7	0.6	-0.3	-1.1	-0.7	0.4	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	2.1	0.1	-0.4	-0.1	-0.5	0.1	0.1	-0.2	-0.3	-0.1	-1.4	-1.2
Hair/balding pattern: Pattern 4	5.6	13.6	28.4	3.6	2.9	-4.2	1.0	-4.8	4.4	0.4	-4.1	-4.2	2.0	5.3
Birth weight of first child	0.3	0.5	1.6	-0.2	0.3	1.3	1.0	0.8	-0.8	-0.8	0.4	0.7	0.6	-0.5
Peak expiratory flow (PEF)	1.7	3.9	10.0	-2.1	-2.3	0.1	-2.9	1.1	-1.2	3.2	1.4	1.0	-2.4	2.0
Pulse wave reflection index	0.6	0.7	2.7	0.4	0.8	0.7	1.6	0.6	-0.5	-1.3	-0.5	0.5	0.7	-0.8
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.4	-0.2	-0.3	0.7	0.3	1.0	-0.4	-1.2	0.4	0.7	-0.5	-0.9
Loud music exposure frequency	0.5	0.6	2.7	-0.8	0.2	-0.7	-0.0	-0.3	0.5	-0.4	-0.5	-0.5	-1.7	-1.0
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.2	0.1	-0.6	-0.6	-1.1	-0.5	0.3	1.0	-0.0	-0.4	-0.6	1.0
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	3.1	0.3	-0.7	1.8	-0.1	1.7	-1.1	-0.7	1.5	1.4	-0.5	-0.0
Blood clot in the leg (DVT)	0.3	0.4	1.7	-1.1	-0.2	-0.2	0.2	0.2	-0.3	-0.5	0.0	0.3	-0.9	-1.3
Medication: Paracetamol	0.5	0.9	3.9	-0.0	-0.4	-0.2	-1.2	-0.7	0.7	0.4	-0.3	-0.9	-1.5	2.0
Headache pain in last month	0.4	0.6	3.8	-0.2	-0.5	-0.5	-1.0	-0.2	0.4	0.7	-0.4	-0.4	-0.8	1.9
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	6.5	0.7	0.4	-0.2	-0.1	-0.9	0.4	0.3	-1.0	-0.6	-0.2	2.6
Glaucoma (self-reported)	1.3	1.6	5.0	0.1	1.0	1.6	2.0	0.7	-0.4	-2.2	-0.0	0.5	0.7	-1.9
Gout (self-reported)	0.5	0.6	1.4	-0.5	0.0	1.2	0.6	1.0	-0.9	-1.0	0.6	1.0	-0.0	-0.9
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	3.1	1.8	0.5	-1.0	0.2	-0.8	0.7	-0.5	-0.8	-0.6	0.5	0.3
Medication: Amlodipine	0.2	0.3	1.4	-0.7	-0.3	-0.3	-0.6	-0.3	0.2	0.2	0.1	-0.3	-0.5	-1.2
Medication: Ventolin 100micrograms inhaler	0.8	1.0	3.3	0.7	0.7	-1.3	1.0	-0.6	0.9	-1.0	-0.8	-0.7	0.9	-1.8
Birth weight	0.3	0.7	1.6	-0.4	-0.9	0.2	-0.8	0.8	-0.7	0.7	1.3	0.7	-1.0	1.1
Chronic bronchitis/emphysema (mother)	1.7	2.0	5.0	-1.1	-1.0	1.3	-0.5	1.6	-1.6	-0.4	1.9	1.8	-1.2	-2.2
High blood pressure (siblings)	0.5	0.7	3.9	-0.6	-0.8	0.1	-0.6	0.4	-0.3	0.3	0.9	0.4	-0.9	-2.0
Forced vital capacity (FVC), Best measure	0.4	1.6	3.8	0.0	1.2	-0.8	0.2	-1.9	1.7	0.5	-1.6	-1.9	-0.8	1.0
Body fat percentage	0.4	1.7	3.5	-0.8	-1.5	-0.3	-1.5	1.2	-1.3	1.9	1.6	1.3	-0.2	1.7
Leg fat percentage (right)	0.5	1.6	2.8	-0.8	-1.5	0.1	-1.4	1.5	-1.4	1.6	1.7	1.5	0.3	1.0
Arm fat-free mass (right)	0.2	1.1	3.2	-1.8	-1.0	0.8	-1.3	0.7	-0.3	1.2	0.9	0.5	-1.5	0.5
Exposure to tobacco smoke outside home	1.0	1.4	2.6	1.5	1.3	-0.4	1.1	-1.1	1.6	-1.6	-0.8	-1.2	1.1	0.1
Comparative body size at age 10	1.2	3.2	5.2	-1.3	-2.3	-0.2	-1.9	2.2	-2.0	1.4	1.9	2.1	-2.2	-0.8
Number of full brothers	0.5	0.7	2.0	0.0	0.5	-1.4	0.4	-0.9	1.0	-1.0	-0.9	-0.8	0.1	-0.7
Worry too long after embarrassment	0.2	0.3	0.7	0.6	0.4	0.6	0.4	0.0	0.4	-0.8	-0.3	-0.4	-0.8	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	1.0	0.2	-0.5	0.9	-0.6	0.0	0.2	0.1	-0.4	-0.2	-1.0	-0.2
Wheeze or whistling in the chest in last year	3.3	5.9	9.9	1.8	3.1	-2.0	3.0	-2.2	2.5	-3.1	-2.3	-2.2	1.6	-2.3
Number of children fathered	0.5	0.6	1.0	-0.9	-1.0	0.3	-0.7	0.8	-1.0	0.7	1.0	1.0	-0.5	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.8	3.6	1.0	1.4	0.2	1.8	-1.1	1.0	-1.6	-1.5	-1.0	1.5	-1.9
Age at first live birth	0.2	0.4	1.0	0.8	0.7	0.7	0.4	-0.5	0.8	-0.3	-0.4	-0.6	-0.1	1.0
Pulse wave peak to peak time	0.3	0.3	1.6	-0.6	0.3	1.3	0.2	-0.2	0.4	-0.1	0.3	-0.1	-0.1	-1.0
Health satisfaction	0.3	0.4	1.0	1.0	-0.1	-0.6	-0.5	-0.5	0.7	0.3	-0.2	-0.5	0.7	0.9
Shortness of breath walking on level ground	3.5	4.1	8.2	-2.9	-2.2	0.8	-2.0	2.3	-2.4	1.9	2.4	2.2	-1.6	0.6
Qualifications: College or University degree	0.8	2.6	7.9	-0.4	-2.0	-1.3	-2.8	0.5	-1.2	2.6	0.2	0.5	-1.9	1.8
Eye problems/disorders: None of the above	0.8	0.9	2.0	-0.5	-1.0	-1.2	-1.4	0.5	-0.4	1.4	0.7	0.5	-1.3	0.7
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.7	-1.1	-1.3	-0.3	-1.2	0.8	-0.5	0.9	0.5	0.6	-0.1	0.9
Emphysema/chronic bronchitis	0.5	0.5	1.3	0.5	-0.9	0.2	-0.9	0.7	-0.0	-0.6	0.7	0.6	-0.9	-1.2
Medication for pain relief, constipation, heartburn	0.4	0.7	1.6	0.3	-0.4	0.7	-0.2	1.0	-0.9	1.3	1.2	1.1	0.3	0.7
Neck or shoulder pain in last month	0.2	0.3	0.9	0.9	-0.5	0.1	-0.6	0.3	-0.6	-0.4	0.1	0.5	-0.9	0.3
Medication: Blood pressure	0.5	1.0	7.8	-0.7	-0.1	-0.9	0.3	0.6	-0.3	-0.3	0.6	0.4	0.2	-2.8
Angina (self-reported)	1.1	1.5	3.5	-1.1	-0.7	0.4	0.1	1.9	-1.7	-0.2	1.4	1.7	-0.4	-1.6
Migraine (self-reported)	1.2	1.5	4.1	0.5	1.0	-2.0	1.1	-0.9	0.6	-2.0	-1.3	-0.8	-0.1	-1.6
Medication: Ibuprofen	1.0	1.2	4.2	0.9	0.8	-2.1	0.3	-1.1	0.6	-0.7	-1.7	-1.0	-0.3	1.1
Medication: Allopurinol	0.6	0.8	4.3	-0.1	0.3	0.3	0.8	0.6	-0.5	-1.4	0.5	0.7	0.4	-2.1
Medication: Omeprazole	0.6	0.7	3.8	-0.3	0.6	-0.4	1.0	-0.1	0.1	-1.6	-0.5	-0.2	0.0	-1.9
Medication: Seretide 50 evohaler	1.5	1.7	3.4	0.3	0.9	-1.6	0.4	-1.5	1.6	-1.1	-1.7	-1.7	-0.7	-1.8
Mean time to correctly identify matches	0.2	0.4	1.3	-0.5	0.8	-0.6	1.1	-0.3	0.5	-0.6	-0.5	-0.4	0.2	-0.4
Heart disease (mother)	0.8	1.0	1.8	-0.7	-1.2	1.4	-1.2	0.9	-0.8	1.4	1.1	0.9	-0.3	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.1	-1.0	-1.6	0.3	-1.7	0.8	-1.2	1.8	0.9	1.2	-0.2	1.5
Whole body fat mass	0.5	2.1	4.5	-1.2	-1.7	-0.3	-1.9	1.2	-1.2	2.1	1.6	1.2	-0.7	1.8
Leg fat mass (right)	0.7	2.7	6.5	-1.2	-2.0	-0.3	-2.3	1.4	-1.4	2.5	1.8	1.4	-0.7	1.7
Arm predicted mass (right)	0.2	1.0	2.4	-1.6	-1.0	0.6	-1.2	0.7	-0.3	1.2	0.9	0.4	-1.5	0.5
Pulse rate, automated reading	0.5	1.6	5.6	-0.9	-1.1	-1.6	-1.9	0.1	-0.2	2.4	0.5	-0.2	-1.7	0.9
Alcohol intake frequency.	1.7	3.9	8.9	1.5	1.2	-3.0	-0.2	-2.6	2.4	0.8	-2.1	-2.6	0.9	2.3
Comparative height size at age 10	0.1	0.8	2.0	0.1	1.1	1.2	0.7	-1.1	1.4	-0.4	-0.4	-1.2	-0.3	0.4
Number of full sisters	0.9	1.1	4.5	-0.2	-1.3	-0.5	-1.5	0.3	-0.6	2.1	0.3	0.4	0.2	1.5
Suffer from ‘nerves’	0.2	0.3	0.7	0.8	0.7	0.3	0.4	-0.4	0.8	-0.5	-0.6	-0.6	-0.1	0.3
Overall health rating	2.1	4.5	6.8	2.4	2.4	-1.4	2.0	-2.3	2.6	-2.4	-2.0	-2.2	2.0	-0.5
Chest pain or discomfort	2.2	3.1	5.9	1.7	2.3	-0.7	2.4	-1.3	1.3	-2.4	-1.6	-1.3	1.6	-2.1
Had major operations	0.2	0.3	0.8	0.4	0.6	0.1	0.6	-0.5	0.5	-0.7	0.1	-0.4	0.9	-0.4
Age at last live birth	0.4	0.6	1.6	0.7	1.0	0.4	0.8	-0.9	0.9	-0.1	-0.5	-0.8	0.5	1.3
Family relationship satisfaction	1.9	2.4	8.1	0.3	1.6	0.9	2.6	0.4	0.0	-2.8	-0.3	0.3	1.0	-2.5
Leg pain on walking	2.6	3.2	6.6	-1.9	-2.5	-0.9	-2.6	1.4	-1.4	2.3	1.5	1.4	-1.8	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.6	-0.2	0.3	-0.8	-0.0	-0.3	0.6	0.1	-0.0	-0.3	-0.5	0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.8	-0.3	0.6	0.7	0.6	-0.2	0.3	0.3	0.1	-0.2	0.9	0.3
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	3.1	-0.5	-1.5	0.0	-1.5	1.0	-1.4	1.8	1.3	1.2	-0.7	1.6
Medication: Aspirin	0.7	0.9	2.9	-1.1	-0.0	1.7	0.8	0.9	-0.4	-0.8	0.6	0.6	0.3	-1.6
Supplements: Vitamin C	0.5	0.5	1.4	0.4	0.4	0.9	0.1	-0.9	1.2	0.2	-1.0	-1.1	0.4	0.6
Knee pain experienced in last month	0.5	0.8	2.5	0.2	0.8	-0.9	0.9	-0.6	0.6	-1.6	-1.2	-0.7	0.1	-1.1
Hypertension (Self-reported)	0.3	0.7	5.9	-0.8	0.1	-0.3	0.5	0.2	-0.2	-1.0	0.2	0.2	0.2	-2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.2	4.9	10.7	1.1	2.6	0.1	3.0	-1.6	1.8	-3.2	-1.9	-1.6	2.0	-3.3
Illnesses of father: Heart disease	0.9	1.3	4.1	1.5	1.1	-2.0	1.3	-0.7	1.0	-0.9	-0.6	-0.6	1.4	-0.1
Illnesses of siblings: Diabetes	2.0	2.5	4.3	1.6	2.1	0.1	1.6	-1.8	1.9	-1.7	-1.4	-1.7	1.8	-0.0
Smoking status: Previous	1.2	1.8	7.2	-0.1	-1.8	-1.2	-2.7	-0.1	0.2	1.3	0.2	-0.1	-2.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	3.1	0.8	1.4	-0.9	0.6	-1.5	1.4	-0.5	-1.8	-1.6	0.1	1.5
Whole body fat-free mass	0.3	1.8	4.5	-1.9	-1.4	0.4	-1.9	0.8	-0.5	1.7	1.2	0.6	-2.1	0.7
Leg fat-free mass (right)	0.4	2.3	5.5	-1.8	-1.6	-0.0	-2.2	0.8	-0.5	2.2	1.2	0.5	-2.3	1.2
Arm fat percentage (left)	0.7	2.8	5.4	-1.0	-2.1	-0.8	-2.3	1.5	-1.7	2.3	1.8	1.6	-0.8	1.7
Average weekly red wine intake	3.7	5.4	10.7	-2.7	-1.6	2.9	-0.4	3.3	-2.8	0.4	2.7	3.0	-1.8	-1.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.3	-0.8	-0.6	1.1	-0.5	0.6	-0.9	0.8	0.7	0.7	0.1	-0.2
Mood swings	0.9	1.6	3.5	1.2	1.3	-0.9	1.2	-1.5	1.3	-1.5	-1.9	-1.2	0.1	0.7
Loneliness, isolation	3.1	4.3	5.6	2.2	2.4	-1.5	2.2	-2.3	2.2	-1.9	-2.2	-2.2	2.3	-0.0
Long-standing illness, disability or infirmity	0.3	0.4	1.2	1.1	0.7	-0.4	0.6	-0.7	0.6	-0.4	-0.3	-0.6	0.9	-0.2
Ever had bowel cancer screening	0.4	0.5	2.5	-0.9	0.5	0.4	0.7	-0.1	0.1	-0.1	-0.3	-0.0	0.9	-1.6
Diabetes diagnosed by doctor	0.9	1.5	4.8	0.7	1.0	1.6	1.8	0.3	-0.0	-1.5	0.6	0.3	2.2	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.8	-0.7	-0.9	0.3	-0.9	0.9	-0.4	0.5	1.1	0.8	-1.7	-1.3
Friendships satisfaction	1.5	1.8	5.5	0.8	1.6	0.9	2.3	-0.5	0.7	-2.1	-0.8	-0.5	1.3	-1.6
Qualifications: nursing, teaching	0.3	0.5	2.0	1.0	-0.3	1.4	-0.6	0.0	-0.2	0.3	-0.2	-0.0	0.1	1.4
Commuting to job workplace: Walk	0.2	0.3	0.6	-0.1	-0.5	-0.2	-0.1	0.7	-0.7	0.0	0.8	0.8	-0.4	-0.3
Eye problems/disorders: Cataract	0.4	0.4	1.8	-0.2	0.7	0.6	1.0	-0.1	0.0	-0.4	0.2	0.0	1.4	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.9	-1.0	-0.8	-0.8	-0.8	0.6	-0.7	0.6	0.7	0.6	-0.6	0.3
Medication for cholesterol	0.4	0.6	1.5	0.3	-0.4	-0.8	-1.1	-0.6	0.6	1.2	-0.3	-0.8	-0.8	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.9	-0.1	0.5	0.2	0.0	-1.2	1.4	-0.1	-0.5	-1.0	0.1	0.8
Back pain experienced in last month	0.5	0.7	2.0	0.5	1.2	0.0	1.2	-0.6	0.8	-1.4	-0.5	-0.5	0.5	-1.2
Mineral and other dietary supplements	0.3	0.4	1.1	-0.1	-0.1	0.3	0.3	0.7	-0.8	-1.0	0.3	0.7	-0.4	-0.8
Breast cancer (self-reported)	0.2	0.2	0.5	0.2	0.5	-0.3	0.2	-0.5	0.7	-0.5	-0.4	-0.6	0.5	0.4
Asthma (self-reported)	1.8	3.7	6.2	2.3	2.1	-1.9	1.3	-2.3	2.4	-1.4	-2.5	-2.4	0.8	0.2
Osteoporosis (self-reported)	0.1	0.1	0.4	0.3	0.2	0.3	0.4	0.1	-0.1	-0.6	0.3	0.1	0.5	0.5
Osteoarthritis (self-reported)	0.6	0.8	3.4	1.8	-0.0	-1.2	-0.4	-0.8	1.0	-0.2	-0.2	-0.8	-0.0	1.0
Medication: Aspirin	0.7	1.0	3.6	-0.9	0.0	1.9	0.9	0.9	-0.3	-1.2	0.6	0.6	0.4	-1.5
Medication: Gliclazide	0.6	0.7	2.4	0.7	0.9	-0.6	1.1	-0.6	0.6	-1.5	-0.2	-0.4	1.1	-0.5
Illnesses of father: None of the above (group 1)	0.3	0.4	1.2	-0.0	-0.2	0.1	-0.9	-0.6	0.2	0.9	-0.6	-0.6	-0.3	1.1
Smoking status: Current	0.1	0.1	0.3	0.4	0.1	0.4	0.1	-0.5	0.5	-0.4	-0.6	-0.3	0.1	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	11.6	-1.2	-1.6	0.1	-2.7	-0.2	-0.4	3.4	0.7	-0.1	-1.7	2.3
Whole body water mass	0.3	1.8	4.5	-1.9	-1.4	0.4	-1.9	0.8	-0.5	1.7	1.2	0.6	-2.1	0.7
Leg predicted mass (right)	0.4	2.3	5.4	-1.8	-1.6	0.0	-2.2	0.8	-0.6	2.2	1.2	0.5	-2.3	1.3
Arm fat mass (left)	0.8	3.1	6.0	-1.3	-2.3	-0.4	-2.4	1.6	-1.6	2.3	1.9	1.6	-1.3	1.7
Number of self-reported non-cancer illnesses	0.7	1.2	4.1	1.0	1.1	0.6	1.6	-0.1	0.8	-2.0	-0.1	-0.3	0.3	-2.0
Average weekly champagne plus white wine intake	1.3	1.8	4.3	-0.9	-1.7	0.9	-1.6	1.2	-1.4	0.4	0.9	1.3	-2.1	-1.5
Miserableness	1.3	2.3	5.3	1.2	1.9	-0.3	1.6	-1.7	1.7	-1.6	-2.3	-1.7	0.9	0.2
Guilty feelings	0.4	0.5	1.1	1.0	0.9	0.8	1.0	-0.3	0.7	-1.0	-0.4	-0.5	0.2	-0.6
Wears glasses or contact lenses	4.6	5.2	12.4	-1.1	-3.3	0.9	-3.5	2.0	-1.7	2.9	2.5	1.7	-2.3	1.6
Ever taken oral contraceptive pill	0.2	0.2	0.5	-0.0	0.4	0.4	0.4	-0.4	0.1	-0.7	-0.6	-0.3	-0.4	-0.6
Hearing aid user	0.7	0.8	1.7	-0.7	-1.0	1.0	-0.4	1.2	-1.3	-0.4	0.9	1.3	-0.8	-0.7
Mother’s age at death	0.3	0.4	1.3	-0.3	0.4	1.1	0.7	0.4	-0.1	-0.8	-0.1	0.1	0.9	-0.6
Financial situation satisfaction	0.8	1.0	2.9	1.2	0.9	-1.7	0.6	-0.8	0.8	-0.7	-0.7	-0.7	1.5	0.6
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.0	0.7	0.8	1.4	0.9	-0.6	0.7	-0.2	-0.1	-0.6	0.8	-0.9
Commuting to job workplace: Public transport	1.1	1.3	2.5	1.6	0.9	-1.2	0.2	-1.4	1.3	-0.2	-1.3	-1.3	0.4	1.5
Eye problems/disorders: Glaucoma	0.5	0.6	2.2	0.9	0.5	1.2	0.9	0.1	0.0	-1.5	-0.5	-0.1	0.4	-0.7
Medication: Blood pressure	0.4	0.7	2.2	-1.0	-0.1	1.3	0.6	0.5	-0.4	-0.8	0.8	0.7	0.1	-1.5
Pain type(s) experienced in last month: Hip pain	1.8	2.3	3.4	1.6	1.6	-0.5	1.3	-1.8	1.8	-1.5	-1.8	-1.7	1.5	-0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.6	-0.2	0.4	-0.1	0.5	-0.5	0.6	0.2	-0.5	-0.6	0.7	0.6
High cholesterol (Self-reported)	0.4	0.7	2.7	-0.6	0.0	1.0	0.5	0.7	-0.8	-0.3	0.9	0.8	0.8	-1.6
Medication: Bendroflumethiazide	0.4	0.7	4.4	-0.1	0.4	-1.2	0.7	-0.2	0.3	-0.5	-0.1	-0.2	0.5	-2.1
Medication: Paracetamol	0.4	0.6	3.0	0.3	0.3	-0.3	-0.2	-0.8	0.8	-0.2	-0.6	-1.0	-0.7	1.7
Medication: Lisinopril	0.9	1.1	3.5	1.0	1.3	0.4	1.9	-0.4	0.8	-1.7	-0.1	-0.5	0.9	-1.1
Medication: Atorvastatin	1.8	2.2	4.5	-1.1	-2.0	0.6	-1.2	2.0	-2.1	0.3	1.9	2.0	-0.5	-1.2
Illnesses of father: High blood pressure	0.3	0.4	0.8	-0.2	-0.6	-0.1	-0.3	0.8	-0.8	-0.4	0.8	0.9	-0.7	-0.2
Alcohol drinker status: Never	2.7	3.2	7.5	1.1	1.6	-1.9	0.4	-2.7	2.4	0.1	-2.5	-2.7	1.0	-0.2
Ever smoked	0.3	0.5	1.6	0.5	-0.7	-1.3	-1.1	-0.3	0.6	-0.2	-0.3	-0.3	-1.0	-0.4
Basal metabolic rate	0.3	1.9	3.8	-1.8	-1.5	0.3	-1.9	0.9	-0.6	1.8	1.3	0.7	-2.0	0.9
Leg fat percentage (left)	0.5	1.9	3.2	-1.2	-1.6	0.4	-1.4	1.6	-1.5	1.7	1.8	1.7	0.0	0.9
Arm fat-free mass (left)	0.2	1.2	2.8	-1.5	-1.1	0.8	-1.5	0.8	-0.4	1.4	1.2	0.6	-1.7	0.4
Number of operations (self-reported)	0.2	0.3	1.1	1.0	-0.4	-0.7	-0.5	0.1	-0.4	0.6	0.5	0.2	0.4	0.2
Average weekly beer plus cider intake	2.6	3.8	9.8	2.2	2.3	-0.0	2.2	-1.9	1.8	-1.6	-2.0	-1.9	3.1	-0.3
Irritability	0.3	0.6	1.5	1.0	0.5	-0.2	0.3	-0.8	0.8	-1.0	-1.2	-0.8	0.2	0.7
Risk taking	0.3	0.4	2.4	-0.4	-0.2	-0.6	-0.4	0.2	-0.3	0.0	-0.3	0.1	-1.0	-1.6
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.8	-0.4	-1.2	0.5	-1.4	0.8	-0.7	1.9	1.3	0.8	-0.4	1.7
Fractured/broken bones in last 5 years	0.9	1.2	2.4	1.4	1.4	1.0	1.6	-0.7	1.0	-1.2	-1.0	-0.8	1.2	-0.5
Age started oral contraceptive pill	1.1	1.4	3.3	1.3	1.0	-0.7	0.4	-1.8	1.6	-0.4	-1.6	-1.6	0.7	0.6
Diastolic blood pressure, automated reading	0.4	1.3	2.8	-1.1	-0.8	1.2	-0.3	1.5	-1.1	0.2	1.6	1.3	-1.7	-0.7
Ever depressed for a whole week	1.2	1.5	3.0	-0.2	-1.7	1.0	-1.6	1.4	-1.1	0.9	1.6	1.3	-1.0	0.6
Unable to work because of sickness or disability	0.3	0.4	1.6	1.3	-0.1	-0.7	-0.3	-0.9	0.6	-0.4	-0.7	-0.7	0.3	0.0
Commuting to job workplace: Cycle	1.9	2.3	3.8	-1.8	-1.9	0.9	-1.7	1.9	-1.8	1.2	1.3	1.6	-1.7	0.2
Myopia	0.3	0.4	1.5	0.1	-0.3	-1.0	-1.0	-0.5	0.3	1.2	-0.3	-0.4	0.2	0.4
Vascular/heart problems diagnosed by doctor	0.5	1.5	6.9	2.0	0.6	-0.1	-0.2	-1.2	1.1	0.6	-1.0	-1.1	0.2	2.6
Cholesterol lowering medication	0.5	0.8	3.2	-0.1	0.9	-0.3	1.4	0.1	-0.2	-1.5	-0.3	0.2	0.4	-1.8
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	5.1	-0.3	0.8	-0.7	0.9	-0.5	0.6	-1.5	-0.8	-0.6	0.1	-2.3
Pain experienced in last month	0.4	0.6	2.5	-0.0	-0.7	0.2	-0.7	0.5	-0.5	1.6	0.9	0.6	0.7	0.9
Supplements: Calcium	0.5	0.5	2.2	-0.0	0.1	0.3	-0.3	-0.6	0.2	1.5	-0.4	-0.4	1.0	1.3
Basal cell carcinoma (self-reported)	0.3	0.3	0.7	0.2	0.7	0.8	0.5	-0.8	0.4	0.1	-0.3	-0.6	0.7	0.6
Heart attack/myocardial infarction (self-reported)	1.3	1.7	3.3	-1.4	-0.9	0.9	0.1	1.8	-1.5	-0.7	1.6	1.8	-0.4	-1.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	2.1	-1.0	-0.2	0.1	0.3	0.2	-0.3	-0.4	0.2	0.3	-0.9	-1.5
Heart disease (siblings)	0.1	0.2	0.4	0.4	0.5	0.6	0.5	-0.1	0.5	-0.6	-0.1	-0.1	-0.0	0.4
Alcohol drinker status: Previous	1.1	1.3	2.9	0.9	0.3	-1.6	-0.4	-1.3	1.4	0.2	-1.7	-1.5	-0.6	1.0
Pack years of smoking	0.3	0.4	2.6	0.6	-0.2	-0.9	-0.4	-0.2	0.2	0.3	-0.0	-0.1	0.7	1.6
Impedance of whole body	1.7	8.5	15.4	2.9	3.8	-0.5	3.9	-2.7	2.6	-3.4	-2.9	-2.5	3.7	-0.1
Leg fat mass (left)	0.7	2.6	6.1	-1.3	-2.0	-0.1	-2.2	1.4	-1.4	2.5	1.8	1.4	-0.7	1.6
Arm predicted mass (left)	0.3	1.5	3.0	-1.7	-1.2	1.0	-1.4	1.0	-0.5	1.4	1.4	0.8	-1.7	0.7