Hub : Genes

TTC35

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Head and Neck Squamous Cell Carcinoma 0.0990 0.0500 5.0e-06 0.072 0.038 0.045 NA 0.066 1.5e-08 3.6e-05 8.5e-06 NA 6.6e-08
2 TCGA Brain Lower Grade Glioma 0.1064 0.0724 8.5e-05 0.046 0.040 0.038 NA 0.040 5.2e-06 2.1e-05 3.4e-05 NA 2.3e-05
3 TCGA Lung Squamous Cell Carcinoma 0.0933 0.0533 5.7e-05 0.037 0.037 0.049 NA 0.026 4.2e-05 4.1e-05 3.0e-06 NA 4.8e-04
4 TCGA Prostate Adenocarcinoma 0.0401 0.0236 3.3e-04 0.017 0.031 0.025 NA 0.031 6.1e-03 2.8e-04 1.0e-03 NA 3.0e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.5 0.8 1.7 0.8 -0.4 -0.9 1.3
Bipolar Disorder or Schizophrenia 1.7 4.2 6.6 -1.9 2.2 -2.6 -1.3
Depressed Affect (Nagel 2018) 1.2 2.6 3.3 -1.6 1.5 -1.4 -1.8
Depression (Nagel 2018) 1.3 1.9 3.9 -1.0 1.5 -2.0 -0.7
Intelligence (Savage-Jansen 2018) 0.4 1.3 4.0 0.6 -0.3 1.0 2.0
Neuroticism (Nagel 2018) 0.6 1.5 1.7 -1.1 1.1 -1.3 -1.2
Schizophrenia (2018) 4.1 8.5 9.9 -3.1 3.1 -2.6 -2.8
Schizophrenia vs Biploar Disorder 0.3 0.4 1.6 -0.1 0.0 0.5 -1.2
Worry (Nagel 2018) 0.5 1.0 1.3 -0.8 1.1 -1.2 -0.9
Alzheimer’s Disease (in mother) 0.2 0.2 0.7 -0.5 0.8 0.2 -0.2
Alzheimer’s Disease (in father) 0.2 0.3 0.6 -0.2 -0.3 0.8 0.5
Alzheimer’s Disease (including proxy) 0.2 0.3 0.8 -0.6 0.1 0.9 0.0
Crohns Disease (2017) 0.0 0.0 0.1 0.1 0.0 -0.3 0.2
Irritable Bowel Disease (IBD) 1.2 3.0 4.0 -1.8 2.0 -1.8 -1.3
Ulcerative Colitis (UC) 2.1 4.0 5.4 -2.2 2.3 -1.7 -1.8
Major Depression (MDD) 1.1 1.3 1.5 -1.2 1.1 -1.1 -1.1
Reaction Time 0.5 0.9 1.2 -1.1 1.1 -0.9 -0.8
Verbal and Numeric Reasoning (VNR) 1.4 3.3 6.5 1.6 -1.4 1.5 2.6
Breast Cancer 0.2 0.5 0.8 -0.9 0.9 -0.2 -0.6
Ovarian Cancer 0.3 0.4 1.1 0.2 0.5 0.5 -1.1
Prostate Cancer 0.1 0.2 0.3 -0.5 0.0 0.5 0.4
Age at First Birth 0.2 0.2 0.5 0.0 0.6 -0.3 -0.7
Bipolar Disorder (2011) 0.7 0.7 1.7 1.0 -0.4 -0.2 1.3
Body Mass Index (BMI) (2010) 0.9 1.2 2.2 1.5 -1.3 0.9 -0.3
Coronary Artery Disease (CAD) 0.3 0.4 1.1 0.2 -0.1 1.1 -0.5
Crohns Disease (2012) 0.1 0.1 0.4 -0.1 -0.0 0.6 -0.1
Mean Putamen Volume 3.5 3.9 4.9 -1.9 2.2 -2.2 -1.6
Fasting Glucose 1.2 1.4 2.2 1.4 -1.5 0.5 1.1
HbA1C 0.9 1.0 1.7 -1.0 1.0 -0.3 -1.3
HDL Cholesterol 0.3 0.6 1.5 -0.6 0.6 -1.2 0.1
LDL Cholesterol 0.5 0.8 2.5 1.6 -0.5 0.5 0.2
Lupus 1.7 2.5 4.4 1.1 -1.3 2.1 1.6
Neuroticism (2016) 0.3 0.4 0.6 -0.7 0.3 0.7 -0.8
Primary Biliary Cirrhosis 1.7 2.4 4.7 -2.2 1.7 -0.6 -1.3
Rheumatoid Arthritis 0.4 0.6 1.6 0.6 -0.6 -0.0 1.3
Schizophrenia (2014) 4.5 9.9 10.8 -3.1 3.3 -3.1 -3.1
Triglycerides 0.1 0.1 0.3 -0.0 0.4 0.2 -0.6
Type 2 Diabetes (T2D) (2012) 1.1 1.2 1.7 0.9 -1.3 1.3 0.9
Ulcerative Colitis 2.1 3.1 4.9 -2.2 1.8 -0.9 -1.8
Blood Eosinophil Count 0.1 0.4 0.9 0.2 -0.7 0.2 1.0
Blood Platelet Count 0.0 0.5 1.1 0.5 -0.8 -0.2 1.0
Blood Red Count 0.1 1.2 1.5 -1.2 1.1 -1.2 -0.9
Blood White Count 1.4 10.1 12.0 3.0 -3.5 3.2 3.1
Heel T-Score 4.3 34.3 45.2 6.5 -5.5 4.5 6.7
BMI 1.4 8.3 9.1 3.0 -2.9 2.8 2.8
Height 0.3 5.4 9.1 -3.0 2.1 -1.6 -2.4
Waist Hip Ratio (WHR) 0.0 0.2 0.4 0.7 -0.3 0.5 0.1
Systolic Blood Pressure 0.1 0.4 1.6 -0.0 0.3 0.4 -1.3
Smoking Status 0.2 0.5 1.1 0.5 -0.7 0.4 1.1
Allergy or Eczema 0.4 1.0 1.3 1.1 -1.0 -0.8 1.0
Cardiovascular Disease 0.0 0.1 0.3 0.1 0.1 -0.3 -0.5
Hypothyroidism (self reported) 0.1 0.3 0.6 -0.8 0.6 -0.1 -0.5
Respiratory disease 0.3 0.7 1.1 -0.6 0.9 -1.1 -0.7
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.6 0.8 -0.7 0.2 -0.1
Lung FEV1/FVC ratio 2.0 10.2 31.7 2.0 -1.9 -1.2 5.6
Lung FVC 0.1 0.8 0.9 -0.9 0.9 -0.9 0.7
Neuroticism 0.4 0.9 1.2 -0.8 1.0 -0.7 -1.1
Chronotype (morning person) 0.7 1.6 4.2 0.9 -0.8 0.9 2.0
Hair Pigment 0.3 8.7 18.6 -1.9 1.1 -3.4 4.3
Tanning 0.3 3.2 5.3 1.6 -1.8 1.2 2.3
Hand grip strength (left) 2.8 7.4 9.6 2.9 -3.1 2.2 2.5
Number of treatments/medications taken 1.3 2.3 4.0 -1.4 1.1 -1.5 -2.0
Average weekly spirits intake 0.2 0.2 0.8 0.9 -0.2 0.2 0.1
Sensitivity / hurt feelings 0.3 0.5 0.9 -0.7 0.9 -0.4 -0.5
Frequency of depressed mood in last 2 weeks 2.6 3.7 6.3 -1.6 2.5 -2.0 -1.3
Hearing difficulty/problems: Yes 0.1 0.1 0.5 0.0 0.7 0.0 -0.0
Relative age of first facial hair 0.0 0.0 0.0 -0.0 -0.2 0.2 0.2
Other serious medical condition/disability diagnosed by doctor 1.7 2.2 3.6 -1.9 1.2 -1.4 -1.4
Ever used hormone-replacement therapy (HRT) 0.5 0.7 1.6 -0.7 0.6 -1.3 -0.6
Ever had hysterectomy (womb removed) 0.2 0.2 0.5 0.4 -0.7 0.2 0.3
Systolic blood pressure, automated reading 0.4 1.2 1.6 1.3 -1.3 0.9 0.8
Eye problems/disorders: Diabetes related eye disease 0.3 0.4 1.1 0.3 -0.4 0.5 -1.0
Angina 1.1 1.4 2.2 1.5 -1.2 1.3 0.5
Medication for hormone replacement therapy 0.6 0.6 1.6 -0.6 0.6 -0.4 -1.3
Vitamin and mineral supplements 0.3 0.4 0.7 0.7 -0.7 0.8 0.2
Supplements: Zinc 2.2 2.4 4.6 1.7 -1.2 0.8 2.1
Medication: Co-codamol 0.5 0.6 0.8 -0.9 0.5 -0.9 -0.7
Medication: Metformin 0.3 0.4 0.7 0.2 -0.7 0.8 -0.5
Diabetes (father) 1.7 2.1 3.0 1.4 -1.7 1.7 0.7
Diabetes (mother) 0.1 0.2 0.5 0.7 -0.3 -0.0 0.2
Severe depression (siblings) 0.2 0.2 0.8 0.2 0.2 -0.0 -0.9
Pack years adult smoking proportion 0.0 0.1 0.1 -0.3 0.4 -0.3 -0.1
Impedance of leg (right) 1.0 4.6 8.5 -2.0 2.0 -1.4 -2.9
Leg fat-free mass (left) 0.2 1.0 3.0 0.3 -0.9 0.4 1.7
Trunk fat percentage 0.3 1.3 2.5 0.7 -1.2 0.9 1.6
Hand grip strength (right) 2.0 5.4 7.0 2.5 -2.6 1.7 2.4
Townsend deprivation index at recruitment 3.8 5.4 7.0 -2.6 2.5 -1.9 -2.1
Current tobacco smoking 0.2 0.3 0.7 -0.8 0.4 -0.3 -0.4
Average weekly fortified wine intake 2.2 2.6 3.5 1.5 -1.6 1.5 1.9
Maternal smoking around birth 0.3 0.4 0.7 -0.4 0.7 -0.8 0.4
Fed-up feelings 2.2 3.9 5.1 -1.7 2.1 -2.2 -1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 3.0 4.0 5.4 -2.0 2.3 -2.2 -1.3
Relative age voice broke 0.2 0.3 0.6 0.8 -0.2 0.6 0.6
Taking other prescription medications 0.6 0.9 1.2 1.0 -1.1 1.1 -0.6
Age when periods started (menarche) 0.1 0.1 0.3 0.1 -0.3 -0.5 0.4
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.7 -0.5 -0.0 -0.8 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.5 6.6 2.1 -1.5 0.8 2.6
Tinnitus: Yes, but not now, but have in the past 1.4 1.5 2.2 -1.5 1.1 -0.7 -1.5
Qualifications: CSEs or equivalent 1.0 1.3 2.8 -1.2 0.9 -0.6 -1.7
Serious illness, injury or assault to yourself 0.2 0.3 0.5 -0.7 0.1 -0.1 -0.7
High blood pressure 0.2 0.5 0.8 0.9 -0.7 0.8 -0.0
Hayfever, allergic rhinitis or eczema 0.2 0.5 1.1 0.7 -1.1 -0.2 0.5
Multivitamins +/- minerals 0.4 0.5 0.8 -0.9 0.6 -0.8 0.1
Stomach or abdominal pain in last month 0.6 0.7 2.2 0.1 0.7 -0.2 -1.5
Supplements: Glucosamine 0.5 0.7 1.2 -1.1 0.6 -1.0 0.2
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.3 1.1 -0.8 0.1 0.2
Medication: Atenolol 0.1 0.2 0.3 0.5 -0.5 -0.1 -0.4
Medication: Levothyroxine sodium 0.3 0.6 1.1 -1.0 0.8 -0.4 -0.6
Sitting height 0.2 1.5 2.1 -1.2 0.8 -1.4 -1.4
Chronic bronchitis/emphysema (father) 1.0 1.1 2.0 1.1 -1.4 0.9 0.5
High blood pressure (mother) 0.0 0.0 0.1 0.2 -0.0 -0.2 0.2
Body mass index (BMI) 1.2 4.9 7.2 2.0 -2.2 1.8 2.7
Impedance of leg (left) 0.9 4.1 8.5 -1.8 1.8 -1.3 -2.9
Leg predicted mass (left) 0.2 1.1 3.0 0.3 -1.0 0.5 1.7
Trunk fat mass 0.4 1.9 3.6 0.9 -1.5 1.1 1.9
Waist circumference 0.4 1.6 2.1 1.0 -1.3 1.2 1.5
Number of incorrect matches in round 1.0 1.7 3.3 1.8 -1.4 0.2 1.2
Past tobacco smoking 0.3 0.5 1.0 -0.8 0.4 -0.4 -1.0
Alcohol usually taken with meals 1.1 1.8 3.0 1.7 -1.3 1.2 1.0
Nervous feelings 0.0 0.0 0.1 -0.1 -0.3 0.2 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 1.1 -0.6 1.0 -1.0 0.8
Hearing difficulty/problems with background noise 0.1 0.1 0.3 0.3 -0.5 0.4 0.1
Hair/balding pattern: Pattern 2 0.3 0.4 0.6 -0.8 0.4 -0.6 -0.6
Had menopause 0.2 0.3 0.6 -0.6 0.3 -0.8 -0.1
Had other major operations 0.1 0.1 0.3 0.3 -0.1 -0.3 0.5
Forced vital capacity (FVC) 0.2 0.6 1.3 -1.1 0.6 -0.8 0.4
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 3.6 1.9 -1.4 0.6 1.8
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.4 0.1 0.1 0.6 0.3
Qualifications: None of the above 0.8 1.7 6.1 -0.0 -0.2 0.7 -2.5
Financial difficulties in last 2 years 0.3 0.4 1.2 0.2 -0.2 -1.1 -0.5
Mouth/teeth dental problems 0.6 0.9 2.5 0.6 -0.4 1.6 0.9
Heart attack 1.9 2.5 4.3 1.8 -2.1 1.5 0.4
Allergy 0.1 0.3 0.6 0.3 -0.2 0.6 0.8
Pain all over the body in last month 1.0 1.1 2.6 -1.6 0.8 -0.5 -0.9
Diabetes (self-reported) 0.4 0.7 1.2 0.5 -0.8 0.8 -1.1
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 4.1 1.5 -2.0 0.6 0.3
Medication: Ramipril 0.8 1.0 1.6 1.2 -0.9 1.3 0.4
Medication: Simvastatin 0.1 0.1 0.2 0.4 -0.4 0.2 -0.3
Fluid intelligence score 0.3 0.7 2.2 0.4 -0.4 0.5 1.5
Illnesses of siblings 0.1 0.2 0.4 -0.1 0.1 0.5 0.7
Neuroticism score 0.2 0.5 0.8 -0.8 0.7 -0.3 -0.9
Weight 0.3 1.6 3.0 0.8 -1.4 0.9 1.7
Impedance of arm (right) 0.9 4.2 5.4 -2.3 1.9 -1.9 -2.0
Arm fat percentage (right) 0.8 3.2 5.9 1.4 -1.7 1.3 2.4
Trunk fat-free mass 0.1 0.8 1.2 0.5 -1.1 0.8 1.0
Hip circumference 0.0 0.2 0.5 -0.2 -0.3 0.4 0.7
Time employed in main current job 1.0 1.2 3.5 -0.7 0.8 -1.9 -0.1
Alcohol intake versus 10 years previously 1.4 2.1 3.8 -1.9 1.4 -1.4 -0.8
Father’s age at death 3.6 4.9 7.1 1.6 -2.2 2.7 2.2
Worrier / anxious feelings 1.0 2.0 3.1 -1.0 1.5 -1.3 -1.8
Frequency of tiredness / lethargy in last 2 weeks 2.7 4.4 5.0 -2.0 2.0 -2.2 -2.2
Falls in the last year 0.3 0.4 0.8 0.4 -0.4 0.9 -0.6
Hair/balding pattern: Pattern 3 0.1 0.1 0.1 -0.3 -0.3 0.2 0.3
Number of live births 0.9 1.3 2.0 1.1 -1.4 0.2 1.4
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 4.3 -0.5 0.2 -1.0 2.1
Pulse rate 0.5 0.9 2.1 0.3 -0.1 -1.2 1.4
Happiness 0.5 0.6 1.2 -0.6 1.1 -0.1 -0.8
Noisy workplace 0.3 0.3 0.7 0.7 -0.8 0.2 0.3
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.4 -0.6 0.6 -0.6 -0.1
Serious illness, injury or assault of a close relative in last 2 years 1.9 2.2 5.1 1.2 -1.4 2.3 0.5
Mouth/teeth dental problems: Dentures 2.6 4.5 13.5 -1.4 1.2 -3.7 -0.9
Asthma 2.4 4.8 5.9 -2.3 2.4 -1.9 -2.1
Medication: Ibuprofen (e.g. Nurofen) 1.8 2.2 4.1 -1.6 2.0 -0.8 -1.3
Medication: Cholesterol lowering 2.5 3.9 6.6 2.6 -2.2 1.4 1.5
Depression (self-reported) 0.7 0.8 1.3 0.9 -0.5 1.0 1.1
Medication: Lansoprazole 1.7 2.0 3.8 -1.5 1.1 -0.7 -2.0
Prospective memory result 0.4 0.5 1.3 0.6 -1.1 0.3 0.6
Lung cancer (father) 0.4 0.5 1.4 -0.1 0.7 -1.2 -0.3
Illnesses of mother 0.7 0.8 1.5 -1.2 1.1 -0.8 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.9 3.2 -1.3 1.2 -1.8 1.2
Pulse wave Arterial Stiffness index 0.1 0.2 0.5 -0.0 0.3 -0.7 -0.2
Impedance of arm (left) 1.2 5.5 7.3 -2.7 2.3 -2.0 -2.4
Arm fat mass (right) 0.6 2.5 5.2 1.2 -1.5 1.1 2.3
Trunk predicted mass 0.1 0.8 1.2 0.5 -1.1 0.8 1.0
Standing height 0.3 2.8 5.1 -2.3 1.2 -1.4 -1.6
Length of working week for main job 0.2 0.3 0.5 -0.7 0.6 -0.0 -0.4
Exposure to tobacco smoke at home 1.3 1.5 4.1 -0.8 1.1 -2.0 -0.1
Breastfed as a baby 6.3 7.8 8.6 2.7 -2.9 2.7 2.8
Tense / ‘highly strung’ 0.3 0.4 1.2 -0.4 1.1 -0.3 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.0 0.0 0.2 -0.0 -0.1 -0.1
Hair/balding pattern: Pattern 4 8.1 19.6 43.4 -6.6 4.6 -3.2 -2.0
Birth weight of first child 0.3 0.5 1.2 0.7 -0.6 1.1 -0.1
Peak expiratory flow (PEF) 1.0 2.2 6.6 0.9 -1.2 0.5 2.6
Pulse wave reflection index 0.2 0.2 0.6 0.2 -0.1 0.4 -0.7
Ever highly irritable/argumentative for 2 days 0.8 1.0 2.9 0.6 -0.7 1.7 -0.4
Loud music exposure frequency 0.2 0.2 0.3 -0.5 0.5 -0.1 -0.6
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.6 -0.8 -0.1 -0.4 0.4
Mouth/teeth dental problems: Bleeding gums 1.5 2.0 3.2 1.8 -1.8 1.3 0.3
Blood clot in the leg (DVT) 0.1 0.1 0.2 -0.2 -0.4 0.4 -0.3
Medication: Paracetamol 0.4 0.7 2.4 -0.6 0.2 -1.6 -0.2
Headache pain in last month 0.1 0.2 0.2 -0.5 0.3 -0.5 0.2
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 1.5 -1.2 0.9 -0.9 -0.2
Glaucoma (self-reported) 0.6 0.7 1.5 0.9 -0.4 0.7 -1.2
Gout (self-reported) 0.5 0.7 1.7 0.7 -0.8 1.3 -0.1
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 0.8 -0.9 0.9 -0.3 -0.6
Medication: Amlodipine 0.0 0.0 0.1 0.1 -0.2 -0.2 0.1
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.9 -0.4 0.6 -0.1 -1.0
Birth weight 0.4 0.9 2.0 0.5 -1.4 0.8 0.9
Chronic bronchitis/emphysema (mother) 2.0 2.3 5.6 1.6 -2.4 0.8 0.5
High blood pressure (siblings) 0.4 0.5 1.3 0.6 -1.1 0.5 0.5
Forced vital capacity (FVC), Best measure 0.9 3.2 5.3 -2.3 1.9 -1.8 -0.7
Body fat percentage 0.4 1.7 3.3 0.9 -1.3 0.9 1.8
Leg fat percentage (right) 0.6 2.1 3.2 1.4 -1.4 1.1 1.8
Arm fat-free mass (right) 0.1 0.6 1.0 0.6 -0.9 0.5 1.0
Exposure to tobacco smoke outside home 1.2 1.6 2.6 -0.4 1.0 -1.6 -1.6
Comparative body size at age 10 1.2 3.4 4.3 2.1 -1.9 1.5 1.9
Number of full brothers 0.5 0.6 1.0 -1.0 0.6 -0.3 -0.9
Worry too long after embarrassment 0.1 0.1 0.3 -0.2 -0.0 0.4 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.4 0.0 0.4 -0.6 0.0
Wheeze or whistling in the chest in last year 3.2 5.8 10.3 -2.7 2.1 -1.0 -3.2
Number of children fathered 0.8 0.9 1.8 0.7 -0.9 1.3 0.8
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.3 2.2 -0.9 1.0 -1.2 -1.5
Age at first live birth 0.3 0.5 1.2 -1.1 0.5 -0.1 -0.6
Pulse wave peak to peak time 0.0 0.1 0.1 -0.3 0.1 0.3 -0.0
Health satisfaction 0.1 0.2 0.5 0.2 0.4 -0.7 0.0
Shortness of breath walking on level ground 4.3 5.1 5.8 2.0 -2.4 2.3 2.3
Qualifications: College or University degree 0.3 0.9 3.2 0.5 0.2 0.4 1.8
Eye problems/disorders: None of the above 0.3 0.4 1.3 0.3 -0.4 0.1 1.1
Mouth/teeth dental problems: Loose teeth 0.4 0.5 0.9 0.9 -0.3 0.5 0.9
Emphysema/chronic bronchitis 0.4 0.5 0.9 0.9 -0.7 0.6 -0.1
Medication for pain relief, constipation, heartburn 0.6 1.0 1.6 0.8 -0.8 1.1 1.3
Neck or shoulder pain in last month 0.2 0.2 0.4 0.6 -0.6 -0.4 -0.0
Medication: Blood pressure 0.3 0.5 1.1 1.1 -0.4 0.8 0.0
Angina (self-reported) 1.7 2.2 3.1 1.8 -1.4 1.8 0.7
Migraine (self-reported) 1.1 1.4 2.9 -1.2 0.9 0.5 -1.7
Medication: Ibuprofen 1.3 1.6 3.1 -1.2 1.8 -0.8 -1.0
Medication: Allopurinol 0.5 0.7 1.9 0.6 -0.6 1.4 -0.4
Medication: Omeprazole 0.4 0.5 1.2 -0.4 0.2 0.6 -1.1
Medication: Seretide 50 evohaler 1.6 1.8 2.6 -1.1 1.6 -1.0 -1.5
Mean time to correctly identify matches 0.2 0.3 0.7 -0.8 0.5 -0.4 -0.5
Heart disease (mother) 0.9 1.1 1.7 0.9 -1.2 0.6 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 3.1 0.7 -1.0 1.7 1.8
Whole body fat mass 0.4 1.8 3.7 0.9 -1.3 1.0 1.9
Leg fat mass (right) 0.6 2.5 5.2 1.2 -1.5 1.0 2.3
Arm predicted mass (right) 0.1 0.6 1.0 0.5 -0.9 0.6 1.0
Pulse rate, automated reading 0.2 0.7 2.2 0.2 -0.1 -0.7 1.5
Alcohol intake frequency. 2.4 5.5 8.5 -2.5 2.5 -2.9 -0.9
Comparative height size at age 10 0.1 0.8 1.7 -1.3 0.4 -0.9 -0.8
Number of full sisters 0.5 0.6 2.1 0.3 -0.3 -0.3 1.5
Suffer from ‘nerves’ 0.3 0.5 0.7 -0.6 0.8 -0.8 -0.6
Overall health rating 2.0 4.3 7.1 -2.0 1.9 -1.6 -2.7
Chest pain or discomfort 1.7 2.5 5.0 -1.1 1.5 -1.3 -2.2
Had major operations 0.2 0.2 0.4 -0.1 -0.1 -0.6 -0.6
Age at last live birth 0.4 0.6 1.7 -1.3 0.7 -0.3 -0.5
Family relationship satisfaction 1.2 1.4 3.0 -0.0 0.2 1.6 -1.7
Leg pain on walking 1.8 2.3 5.0 1.3 -1.3 1.0 2.2
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.6 -0.6 0.1 -0.8 -0.1
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.2 0.2 0.0 -0.4 0.1
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 3.1 1.3 -1.0 0.9 1.8
Medication: Aspirin 0.4 0.5 1.1 1.1 -1.0 0.1 -0.1
Supplements: Vitamin C 0.5 0.6 0.9 -0.9 1.0 -0.6 -0.3
Knee pain experienced in last month 0.5 0.8 1.8 -0.5 1.0 -0.5 -1.3
Hypertension (Self-reported) 0.1 0.3 0.6 0.5 -0.4 0.8 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.9 3.4 8.4 -1.6 1.3 -1.0 -2.9
Illnesses of father: Heart disease 0.3 0.4 0.8 -0.7 0.5 -0.5 -0.9
Illnesses of siblings: Diabetes 2.4 2.9 3.5 -1.5 1.5 -1.9 -1.9
Smoking status: Previous 0.2 0.2 0.7 0.5 0.1 -0.0 0.8
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.3 3.6 -1.8 1.9 -1.1 -1.0
Whole body fat-free mass 0.2 1.0 2.0 0.6 -1.2 0.7 1.4
Leg fat-free mass (right) 0.2 1.1 2.8 0.3 -1.0 0.5 1.7
Arm fat percentage (left) 0.6 2.6 4.9 1.2 -1.5 1.2 2.2
Average weekly red wine intake 4.8 7.1 10.0 3.2 -3.0 2.5 1.7
Handedness (chirality/laterality): Left-handed 0.4 0.5 0.7 0.4 -0.6 0.8 0.8
Mood swings 1.4 2.6 3.6 -1.6 1.9 -1.3 -1.6
Loneliness, isolation 3.0 4.2 6.2 -2.5 2.0 -1.2 -2.3
Long-standing illness, disability or infirmity 0.2 0.4 0.5 -0.7 0.3 -0.7 -0.6
Ever had bowel cancer screening 0.0 0.0 0.0 -0.0 0.0 -0.1 -0.0
Diabetes diagnosed by doctor 0.3 0.5 0.6 0.7 -0.8 0.4 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.1 0.7 -1.1 -0.2 0.7
Friendships satisfaction 0.7 0.9 2.5 -0.5 0.7 0.6 -1.6
Qualifications: nursing, teaching 0.0 0.0 0.1 0.1 0.1 -0.2 0.1
Commuting to job workplace: Walk 0.5 0.5 1.1 0.6 -0.7 1.0 0.4
Eye problems/disorders: Cataract 0.0 0.0 0.1 0.1 -0.2 0.0 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.0 0.7 -0.6 1.0 0.8
Medication for cholesterol 0.2 0.4 0.6 -0.8 0.6 -0.6 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 1.9 -1.1 0.3 -1.4 -0.7
Back pain experienced in last month 0.4 0.6 1.5 -0.9 0.4 -0.1 -1.2
Mineral and other dietary supplements 0.7 0.9 2.9 0.7 -0.4 1.7 -0.4
Breast cancer (self-reported) 0.3 0.3 0.8 -0.9 0.4 -0.2 -0.6
Asthma (self-reported) 2.5 4.9 6.4 -2.3 2.5 -1.8 -2.2
Osteoporosis (self-reported) 0.0 0.1 0.1 0.4 -0.2 -0.0 -0.2
Osteoarthritis (self-reported) 0.6 0.8 2.4 -0.8 -0.1 -1.5 -0.5
Medication: Aspirin 0.5 0.6 1.2 1.1 -1.0 0.2 -0.4
Medication: Gliclazide 0.3 0.3 1.2 -0.3 -0.1 -0.1 -1.1
Illnesses of father: None of the above (group 1) 0.4 0.5 1.0 -0.7 1.0 -0.6 0.2
Smoking status: Current 0.1 0.2 0.4 -0.6 0.3 -0.4 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.5 4.8 -0.0 -0.1 -1.2 2.2
Whole body water mass 0.2 1.0 2.0 0.6 -1.1 0.7 1.4
Leg predicted mass (right) 0.2 1.1 2.8 0.3 -1.1 0.5 1.7
Arm fat mass (left) 0.7 2.8 5.1 1.3 -1.7 1.2 2.3
Number of self-reported non-cancer illnesses 0.3 0.5 1.9 -0.1 -0.2 0.1 -1.4
Average weekly champagne plus white wine intake 1.0 1.4 2.0 1.4 -1.0 1.3 0.9
Miserableness 1.9 3.4 3.9 -2.0 2.0 -1.4 -1.9
Guilty feelings 0.2 0.3 0.7 -0.3 0.2 -0.5 -0.8
Wears glasses or contact lenses 4.9 5.6 8.1 2.3 -2.6 1.5 2.8
Ever taken oral contraceptive pill 0.3 0.3 0.5 -0.7 0.3 0.3 -0.7
Hearing aid user 0.8 0.9 1.7 0.9 -1.3 1.0 0.4
Mother’s age at death 0.1 0.1 0.2 0.3 -0.1 0.2 -0.4
Financial situation satisfaction 0.5 0.6 1.0 -0.8 1.0 -0.2 -0.8
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.9 0.0 0.1 -0.9 -0.4
Commuting to job workplace: Public transport 1.6 2.0 3.6 -1.2 1.4 -1.9 -0.8
Eye problems/disorders: Glaucoma 0.3 0.3 1.1 0.4 0.1 -0.3 -1.1
Medication: Blood pressure 0.3 0.5 1.4 0.7 -1.2 0.3 -0.0
Pain type(s) experienced in last month: Hip pain 2.1 2.6 3.1 -1.6 1.5 -1.6 -1.7
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.6 -0.5 0.3 -1.3 -0.1
High cholesterol (Self-reported) 0.5 0.8 1.6 0.9 -1.3 0.9 0.3
Medication: Bendroflumethiazide 0.1 0.2 0.4 0.2 0.1 -0.6 -0.3
Medication: Paracetamol 0.5 0.7 2.0 -0.6 0.4 -1.4 -0.6
Medication: Lisinopril 0.3 0.4 1.6 0.0 -0.3 -0.1 -1.3
Medication: Atorvastatin 3.5 4.3 5.3 2.3 -2.3 2.3 1.2
Illnesses of father: High blood pressure 0.6 0.8 1.2 1.1 -0.9 1.1 0.3
Alcohol drinker status: Never 4.3 5.2 7.0 -2.2 2.7 -2.6 -1.3
Ever smoked 0.0 0.0 0.1 0.1 0.2 -0.1 -0.2
Basal metabolic rate 0.2 1.2 2.4 0.6 -1.2 0.7 1.5
Leg fat percentage (left) 0.7 2.4 3.5 1.5 -1.6 1.1 1.9
Arm fat-free mass (left) 0.2 0.8 1.4 0.7 -1.0 0.5 1.2
Number of operations (self-reported) 0.1 0.2 0.3 0.5 -0.1 -0.5 0.4
Average weekly beer plus cider intake 2.4 3.4 4.0 -1.9 2.0 -1.5 -2.0
Irritability 0.4 0.7 1.0 -0.4 0.9 -0.9 -1.0
Risk taking 0.2 0.3 0.8 0.1 0.6 0.9 -0.1
Ever had prostate specific antigen (PSA) test 0.9 1.1 2.8 0.8 -0.9 0.2 1.7
Fractured/broken bones in last 5 years 0.7 0.9 1.6 -0.6 0.6 -1.0 -1.3
Age started oral contraceptive pill 1.8 2.3 3.6 -1.5 1.5 -1.9 -1.0
Diastolic blood pressure, automated reading 0.6 1.8 2.9 1.4 -1.7 1.2 0.9
Ever depressed for a whole week 1.6 2.0 2.9 1.2 -1.7 1.4 1.3
Unable to work because of sickness or disability 0.2 0.3 0.7 -0.9 0.4 -0.1 -0.6
Commuting to job workplace: Cycle 1.8 2.2 2.6 1.6 -1.3 1.4 1.6
Myopia 0.2 0.2 0.4 -0.4 0.6 -0.3 0.6
Vascular/heart problems diagnosed by doctor 0.5 1.4 2.5 -1.6 1.3 -1.3 -0.2
Cholesterol lowering medication 0.2 0.2 0.8 0.0 -0.3 0.2 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.5 -0.8 0.5 0.3 -1.2
Pain experienced in last month 0.4 0.7 1.8 0.6 -0.5 0.5 1.3
Supplements: Calcium 0.6 0.7 1.6 -0.4 0.7 -1.3 0.7
Basal cell carcinoma (self-reported) 0.4 0.5 1.1 -1.1 0.5 -0.6 -0.3
Heart attack/myocardial infarction (self-reported) 2.0 2.6 4.1 1.8 -2.0 1.7 0.4
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.3 -0.1 -0.5 0.3 -0.2
Heart disease (siblings) 0.0 0.1 0.1 0.1 0.2 -0.2 -0.4
Alcohol drinker status: Previous 1.6 1.8 3.3 -1.1 1.8 -1.6 -0.6
Pack years of smoking 0.0 0.0 0.0 0.1 0.1 -0.1 0.1
Impedance of whole body 1.6 7.9 11.5 -3.0 2.7 -2.0 -3.4
Leg fat mass (left) 0.6 2.5 5.0 1.2 -1.5 1.0 2.2
Arm predicted mass (left) 0.2 1.1 1.7 0.8 -1.3 0.8 1.3