Hub : Genes

TTC35

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Head and Neck Squamous Cell Carcinoma	0.0990	0.0500	5.0e-06	0.072	0.038	0.045	NA	0.066	1.5e-08	3.6e-05	8.5e-06	NA	6.6e-08
2	TCGA	Brain Lower Grade Glioma	0.1064	0.0724	8.5e-05	0.046	0.040	0.038	NA	0.040	5.2e-06	2.1e-05	3.4e-05	NA	2.3e-05
3	TCGA	Lung Squamous Cell Carcinoma	0.0933	0.0533	5.7e-05	0.037	0.037	0.049	NA	0.026	4.2e-05	4.1e-05	3.0e-06	NA	4.8e-04
4	TCGA	Prostate Adenocarcinoma	0.0401	0.0236	3.3e-04	0.017	0.031	0.025	NA	0.031	6.1e-03	2.8e-04	1.0e-03	NA	3.0e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.8	1.7	0.8	-0.4	-0.9	1.3
Bipolar Disorder or Schizophrenia	1.7	4.2	6.6	-1.9	2.2	-2.6	-1.3
Depressed Affect (Nagel 2018)	1.2	2.6	3.3	-1.6	1.5	-1.4	-1.8
Depression (Nagel 2018)	1.3	1.9	3.9	-1.0	1.5	-2.0	-0.7
Intelligence (Savage-Jansen 2018)	0.4	1.3	4.0	0.6	-0.3	1.0	2.0
Neuroticism (Nagel 2018)	0.6	1.5	1.7	-1.1	1.1	-1.3	-1.2
Schizophrenia (2018)	4.1	8.5	9.9	-3.1	3.1	-2.6	-2.8
Schizophrenia vs Biploar Disorder	0.3	0.4	1.6	-0.1	0.0	0.5	-1.2
Worry (Nagel 2018)	0.5	1.0	1.3	-0.8	1.1	-1.2	-0.9
Alzheimer’s Disease (in mother)	0.2	0.2	0.7	-0.5	0.8	0.2	-0.2
Alzheimer’s Disease (in father)	0.2	0.3	0.6	-0.2	-0.3	0.8	0.5
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	-0.6	0.1	0.9	0.0
Crohns Disease (2017)	0.0	0.0	0.1	0.1	0.0	-0.3	0.2
Irritable Bowel Disease (IBD)	1.2	3.0	4.0	-1.8	2.0	-1.8	-1.3
Ulcerative Colitis (UC)	2.1	4.0	5.4	-2.2	2.3	-1.7	-1.8
Major Depression (MDD)	1.1	1.3	1.5	-1.2	1.1	-1.1	-1.1
Reaction Time	0.5	0.9	1.2	-1.1	1.1	-0.9	-0.8
Verbal and Numeric Reasoning (VNR)	1.4	3.3	6.5	1.6	-1.4	1.5	2.6
Breast Cancer	0.2	0.5	0.8	-0.9	0.9	-0.2	-0.6
Ovarian Cancer	0.3	0.4	1.1	0.2	0.5	0.5	-1.1
Prostate Cancer	0.1	0.2	0.3	-0.5	0.0	0.5	0.4
Age at First Birth	0.2	0.2	0.5	0.0	0.6	-0.3	-0.7
Bipolar Disorder (2011)	0.7	0.7	1.7	1.0	-0.4	-0.2	1.3
Body Mass Index (BMI) (2010)	0.9	1.2	2.2	1.5	-1.3	0.9	-0.3
Coronary Artery Disease (CAD)	0.3	0.4	1.1	0.2	-0.1	1.1	-0.5
Crohns Disease (2012)	0.1	0.1	0.4	-0.1	-0.0	0.6	-0.1
Mean Putamen Volume	3.5	3.9	4.9	-1.9	2.2	-2.2	-1.6
Fasting Glucose	1.2	1.4	2.2	1.4	-1.5	0.5	1.1
HbA1C	0.9	1.0	1.7	-1.0	1.0	-0.3	-1.3
HDL Cholesterol	0.3	0.6	1.5	-0.6	0.6	-1.2	0.1
LDL Cholesterol	0.5	0.8	2.5	1.6	-0.5	0.5	0.2
Lupus	1.7	2.5	4.4	1.1	-1.3	2.1	1.6
Neuroticism (2016)	0.3	0.4	0.6	-0.7	0.3	0.7	-0.8
Primary Biliary Cirrhosis	1.7	2.4	4.7	-2.2	1.7	-0.6	-1.3
Rheumatoid Arthritis	0.4	0.6	1.6	0.6	-0.6	-0.0	1.3
Schizophrenia (2014)	4.5	9.9	10.8	-3.1	3.3	-3.1	-3.1
Triglycerides	0.1	0.1	0.3	-0.0	0.4	0.2	-0.6
Type 2 Diabetes (T2D) (2012)	1.1	1.2	1.7	0.9	-1.3	1.3	0.9
Ulcerative Colitis	2.1	3.1	4.9	-2.2	1.8	-0.9	-1.8
Blood Eosinophil Count	0.1	0.4	0.9	0.2	-0.7	0.2	1.0
Blood Platelet Count	0.0	0.5	1.1	0.5	-0.8	-0.2	1.0
Blood Red Count	0.1	1.2	1.5	-1.2	1.1	-1.2	-0.9
Blood White Count	1.4	10.1	12.0	3.0	-3.5	3.2	3.1
Heel T-Score	4.3	34.3	45.2	6.5	-5.5	4.5	6.7
BMI	1.4	8.3	9.1	3.0	-2.9	2.8	2.8
Height	0.3	5.4	9.1	-3.0	2.1	-1.6	-2.4
Waist Hip Ratio (WHR)	0.0	0.2	0.4	0.7	-0.3	0.5	0.1
Systolic Blood Pressure	0.1	0.4	1.6	-0.0	0.3	0.4	-1.3
Smoking Status	0.2	0.5	1.1	0.5	-0.7	0.4	1.1
Allergy or Eczema	0.4	1.0	1.3	1.1	-1.0	-0.8	1.0
Cardiovascular Disease	0.0	0.1	0.3	0.1	0.1	-0.3	-0.5
Hypothyroidism (self reported)	0.1	0.3	0.6	-0.8	0.6	-0.1	-0.5
Respiratory disease	0.3	0.7	1.1	-0.6	0.9	-1.1	-0.7
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.6	0.8	-0.7	0.2	-0.1
Lung FEV1/FVC ratio	2.0	10.2	31.7	2.0	-1.9	-1.2	5.6
Lung FVC	0.1	0.8	0.9	-0.9	0.9	-0.9	0.7
Neuroticism	0.4	0.9	1.2	-0.8	1.0	-0.7	-1.1
Chronotype (morning person)	0.7	1.6	4.2	0.9	-0.8	0.9	2.0
Hair Pigment	0.3	8.7	18.6	-1.9	1.1	-3.4	4.3
Tanning	0.3	3.2	5.3	1.6	-1.8	1.2	2.3
Hand grip strength (left)	2.8	7.4	9.6	2.9	-3.1	2.2	2.5
Number of treatments/medications taken	1.3	2.3	4.0	-1.4	1.1	-1.5	-2.0
Average weekly spirits intake	0.2	0.2	0.8	0.9	-0.2	0.2	0.1
Sensitivity / hurt feelings	0.3	0.5	0.9	-0.7	0.9	-0.4	-0.5
Frequency of depressed mood in last 2 weeks	2.6	3.7	6.3	-1.6	2.5	-2.0	-1.3
Hearing difficulty/problems: Yes	0.1	0.1	0.5	0.0	0.7	0.0	-0.0
Relative age of first facial hair	0.0	0.0	0.0	-0.0	-0.2	0.2	0.2
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	3.6	-1.9	1.2	-1.4	-1.4
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.6	-0.7	0.6	-1.3	-0.6
Ever had hysterectomy (womb removed)	0.2	0.2	0.5	0.4	-0.7	0.2	0.3
Systolic blood pressure, automated reading	0.4	1.2	1.6	1.3	-1.3	0.9	0.8
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.1	0.3	-0.4	0.5	-1.0
Angina	1.1	1.4	2.2	1.5	-1.2	1.3	0.5
Medication for hormone replacement therapy	0.6	0.6	1.6	-0.6	0.6	-0.4	-1.3
Vitamin and mineral supplements	0.3	0.4	0.7	0.7	-0.7	0.8	0.2
Supplements: Zinc	2.2	2.4	4.6	1.7	-1.2	0.8	2.1
Medication: Co-codamol	0.5	0.6	0.8	-0.9	0.5	-0.9	-0.7
Medication: Metformin	0.3	0.4	0.7	0.2	-0.7	0.8	-0.5
Diabetes (father)	1.7	2.1	3.0	1.4	-1.7	1.7	0.7
Diabetes (mother)	0.1	0.2	0.5	0.7	-0.3	-0.0	0.2
Severe depression (siblings)	0.2	0.2	0.8	0.2	0.2	-0.0	-0.9
Pack years adult smoking proportion	0.0	0.1	0.1	-0.3	0.4	-0.3	-0.1
Impedance of leg (right)	1.0	4.6	8.5	-2.0	2.0	-1.4	-2.9
Leg fat-free mass (left)	0.2	1.0	3.0	0.3	-0.9	0.4	1.7
Trunk fat percentage	0.3	1.3	2.5	0.7	-1.2	0.9	1.6
Hand grip strength (right)	2.0	5.4	7.0	2.5	-2.6	1.7	2.4
Townsend deprivation index at recruitment	3.8	5.4	7.0	-2.6	2.5	-1.9	-2.1
Current tobacco smoking	0.2	0.3	0.7	-0.8	0.4	-0.3	-0.4
Average weekly fortified wine intake	2.2	2.6	3.5	1.5	-1.6	1.5	1.9
Maternal smoking around birth	0.3	0.4	0.7	-0.4	0.7	-0.8	0.4
Fed-up feelings	2.2	3.9	5.1	-1.7	2.1	-2.2	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	3.0	4.0	5.4	-2.0	2.3	-2.2	-1.3
Relative age voice broke	0.2	0.3	0.6	0.8	-0.2	0.6	0.6
Taking other prescription medications	0.6	0.9	1.2	1.0	-1.1	1.1	-0.6
Age when periods started (menarche)	0.1	0.1	0.3	0.1	-0.3	-0.5	0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.7	-0.5	-0.0	-0.8	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.5	6.6	2.1	-1.5	0.8	2.6
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	2.2	-1.5	1.1	-0.7	-1.5
Qualifications: CSEs or equivalent	1.0	1.3	2.8	-1.2	0.9	-0.6	-1.7
Serious illness, injury or assault to yourself	0.2	0.3	0.5	-0.7	0.1	-0.1	-0.7
High blood pressure	0.2	0.5	0.8	0.9	-0.7	0.8	-0.0
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.1	0.7	-1.1	-0.2	0.5
Multivitamins +/- minerals	0.4	0.5	0.8	-0.9	0.6	-0.8	0.1
Stomach or abdominal pain in last month	0.6	0.7	2.2	0.1	0.7	-0.2	-1.5
Supplements: Glucosamine	0.5	0.7	1.2	-1.1	0.6	-1.0	0.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.3	1.1	-0.8	0.1	0.2
Medication: Atenolol	0.1	0.2	0.3	0.5	-0.5	-0.1	-0.4
Medication: Levothyroxine sodium	0.3	0.6	1.1	-1.0	0.8	-0.4	-0.6
Sitting height	0.2	1.5	2.1	-1.2	0.8	-1.4	-1.4
Chronic bronchitis/emphysema (father)	1.0	1.1	2.0	1.1	-1.4	0.9	0.5
High blood pressure (mother)	0.0	0.0	0.1	0.2	-0.0	-0.2	0.2
Body mass index (BMI)	1.2	4.9	7.2	2.0	-2.2	1.8	2.7
Impedance of leg (left)	0.9	4.1	8.5	-1.8	1.8	-1.3	-2.9
Leg predicted mass (left)	0.2	1.1	3.0	0.3	-1.0	0.5	1.7
Trunk fat mass	0.4	1.9	3.6	0.9	-1.5	1.1	1.9
Waist circumference	0.4	1.6	2.1	1.0	-1.3	1.2	1.5
Number of incorrect matches in round	1.0	1.7	3.3	1.8	-1.4	0.2	1.2
Past tobacco smoking	0.3	0.5	1.0	-0.8	0.4	-0.4	-1.0
Alcohol usually taken with meals	1.1	1.8	3.0	1.7	-1.3	1.2	1.0
Nervous feelings	0.0	0.0	0.1	-0.1	-0.3	0.2	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.1	-0.6	1.0	-1.0	0.8
Hearing difficulty/problems with background noise	0.1	0.1	0.3	0.3	-0.5	0.4	0.1
Hair/balding pattern: Pattern 2	0.3	0.4	0.6	-0.8	0.4	-0.6	-0.6
Had menopause	0.2	0.3	0.6	-0.6	0.3	-0.8	-0.1
Had other major operations	0.1	0.1	0.3	0.3	-0.1	-0.3	0.5
Forced vital capacity (FVC)	0.2	0.6	1.3	-1.1	0.6	-0.8	0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	3.6	1.9	-1.4	0.6	1.8
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.4	0.1	0.1	0.6	0.3
Qualifications: None of the above	0.8	1.7	6.1	-0.0	-0.2	0.7	-2.5
Financial difficulties in last 2 years	0.3	0.4	1.2	0.2	-0.2	-1.1	-0.5
Mouth/teeth dental problems	0.6	0.9	2.5	0.6	-0.4	1.6	0.9
Heart attack	1.9	2.5	4.3	1.8	-2.1	1.5	0.4
Allergy	0.1	0.3	0.6	0.3	-0.2	0.6	0.8
Pain all over the body in last month	1.0	1.1	2.6	-1.6	0.8	-0.5	-0.9
Diabetes (self-reported)	0.4	0.7	1.2	0.5	-0.8	0.8	-1.1
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	4.1	1.5	-2.0	0.6	0.3
Medication: Ramipril	0.8	1.0	1.6	1.2	-0.9	1.3	0.4
Medication: Simvastatin	0.1	0.1	0.2	0.4	-0.4	0.2	-0.3
Fluid intelligence score	0.3	0.7	2.2	0.4	-0.4	0.5	1.5
Illnesses of siblings	0.1	0.2	0.4	-0.1	0.1	0.5	0.7
Neuroticism score	0.2	0.5	0.8	-0.8	0.7	-0.3	-0.9
Weight	0.3	1.6	3.0	0.8	-1.4	0.9	1.7
Impedance of arm (right)	0.9	4.2	5.4	-2.3	1.9	-1.9	-2.0
Arm fat percentage (right)	0.8	3.2	5.9	1.4	-1.7	1.3	2.4
Trunk fat-free mass	0.1	0.8	1.2	0.5	-1.1	0.8	1.0
Hip circumference	0.0	0.2	0.5	-0.2	-0.3	0.4	0.7
Time employed in main current job	1.0	1.2	3.5	-0.7	0.8	-1.9	-0.1
Alcohol intake versus 10 years previously	1.4	2.1	3.8	-1.9	1.4	-1.4	-0.8
Father’s age at death	3.6	4.9	7.1	1.6	-2.2	2.7	2.2
Worrier / anxious feelings	1.0	2.0	3.1	-1.0	1.5	-1.3	-1.8
Frequency of tiredness / lethargy in last 2 weeks	2.7	4.4	5.0	-2.0	2.0	-2.2	-2.2
Falls in the last year	0.3	0.4	0.8	0.4	-0.4	0.9	-0.6
Hair/balding pattern: Pattern 3	0.1	0.1	0.1	-0.3	-0.3	0.2	0.3
Number of live births	0.9	1.3	2.0	1.1	-1.4	0.2	1.4
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	4.3	-0.5	0.2	-1.0	2.1
Pulse rate	0.5	0.9	2.1	0.3	-0.1	-1.2	1.4
Happiness	0.5	0.6	1.2	-0.6	1.1	-0.1	-0.8
Noisy workplace	0.3	0.3	0.7	0.7	-0.8	0.2	0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.4	-0.6	0.6	-0.6	-0.1
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	5.1	1.2	-1.4	2.3	0.5
Mouth/teeth dental problems: Dentures	2.6	4.5	13.5	-1.4	1.2	-3.7	-0.9
Asthma	2.4	4.8	5.9	-2.3	2.4	-1.9	-2.1
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.2	4.1	-1.6	2.0	-0.8	-1.3
Medication: Cholesterol lowering	2.5	3.9	6.6	2.6	-2.2	1.4	1.5
Depression (self-reported)	0.7	0.8	1.3	0.9	-0.5	1.0	1.1
Medication: Lansoprazole	1.7	2.0	3.8	-1.5	1.1	-0.7	-2.0
Prospective memory result	0.4	0.5	1.3	0.6	-1.1	0.3	0.6
Lung cancer (father)	0.4	0.5	1.4	-0.1	0.7	-1.2	-0.3
Illnesses of mother	0.7	0.8	1.5	-1.2	1.1	-0.8	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	3.2	-1.3	1.2	-1.8	1.2
Pulse wave Arterial Stiffness index	0.1	0.2	0.5	-0.0	0.3	-0.7	-0.2
Impedance of arm (left)	1.2	5.5	7.3	-2.7	2.3	-2.0	-2.4
Arm fat mass (right)	0.6	2.5	5.2	1.2	-1.5	1.1	2.3
Trunk predicted mass	0.1	0.8	1.2	0.5	-1.1	0.8	1.0
Standing height	0.3	2.8	5.1	-2.3	1.2	-1.4	-1.6
Length of working week for main job	0.2	0.3	0.5	-0.7	0.6	-0.0	-0.4
Exposure to tobacco smoke at home	1.3	1.5	4.1	-0.8	1.1	-2.0	-0.1
Breastfed as a baby	6.3	7.8	8.6	2.7	-2.9	2.7	2.8
Tense / ‘highly strung’	0.3	0.4	1.2	-0.4	1.1	-0.3	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.0	0.2	-0.0	-0.1	-0.1
Hair/balding pattern: Pattern 4	8.1	19.6	43.4	-6.6	4.6	-3.2	-2.0
Birth weight of first child	0.3	0.5	1.2	0.7	-0.6	1.1	-0.1
Peak expiratory flow (PEF)	1.0	2.2	6.6	0.9	-1.2	0.5	2.6
Pulse wave reflection index	0.2	0.2	0.6	0.2	-0.1	0.4	-0.7
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.9	0.6	-0.7	1.7	-0.4
Loud music exposure frequency	0.2	0.2	0.3	-0.5	0.5	-0.1	-0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	-0.8	-0.1	-0.4	0.4
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	3.2	1.8	-1.8	1.3	0.3
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.2	-0.4	0.4	-0.3
Medication: Paracetamol	0.4	0.7	2.4	-0.6	0.2	-1.6	-0.2
Headache pain in last month	0.1	0.2	0.2	-0.5	0.3	-0.5	0.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.5	-1.2	0.9	-0.9	-0.2
Glaucoma (self-reported)	0.6	0.7	1.5	0.9	-0.4	0.7	-1.2
Gout (self-reported)	0.5	0.7	1.7	0.7	-0.8	1.3	-0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	0.8	-0.9	0.9	-0.3	-0.6
Medication: Amlodipine	0.0	0.0	0.1	0.1	-0.2	-0.2	0.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	-0.4	0.6	-0.1	-1.0
Birth weight	0.4	0.9	2.0	0.5	-1.4	0.8	0.9
Chronic bronchitis/emphysema (mother)	2.0	2.3	5.6	1.6	-2.4	0.8	0.5
High blood pressure (siblings)	0.4	0.5	1.3	0.6	-1.1	0.5	0.5
Forced vital capacity (FVC), Best measure	0.9	3.2	5.3	-2.3	1.9	-1.8	-0.7
Body fat percentage	0.4	1.7	3.3	0.9	-1.3	0.9	1.8
Leg fat percentage (right)	0.6	2.1	3.2	1.4	-1.4	1.1	1.8
Arm fat-free mass (right)	0.1	0.6	1.0	0.6	-0.9	0.5	1.0
Exposure to tobacco smoke outside home	1.2	1.6	2.6	-0.4	1.0	-1.6	-1.6
Comparative body size at age 10	1.2	3.4	4.3	2.1	-1.9	1.5	1.9
Number of full brothers	0.5	0.6	1.0	-1.0	0.6	-0.3	-0.9
Worry too long after embarrassment	0.1	0.1	0.3	-0.2	-0.0	0.4	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.4	0.0	0.4	-0.6	0.0
Wheeze or whistling in the chest in last year	3.2	5.8	10.3	-2.7	2.1	-1.0	-3.2
Number of children fathered	0.8	0.9	1.8	0.7	-0.9	1.3	0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.3	2.2	-0.9	1.0	-1.2	-1.5
Age at first live birth	0.3	0.5	1.2	-1.1	0.5	-0.1	-0.6
Pulse wave peak to peak time	0.0	0.1	0.1	-0.3	0.1	0.3	-0.0
Health satisfaction	0.1	0.2	0.5	0.2	0.4	-0.7	0.0
Shortness of breath walking on level ground	4.3	5.1	5.8	2.0	-2.4	2.3	2.3
Qualifications: College or University degree	0.3	0.9	3.2	0.5	0.2	0.4	1.8
Eye problems/disorders: None of the above	0.3	0.4	1.3	0.3	-0.4	0.1	1.1
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.9	0.9	-0.3	0.5	0.9
Emphysema/chronic bronchitis	0.4	0.5	0.9	0.9	-0.7	0.6	-0.1
Medication for pain relief, constipation, heartburn	0.6	1.0	1.6	0.8	-0.8	1.1	1.3
Neck or shoulder pain in last month	0.2	0.2	0.4	0.6	-0.6	-0.4	-0.0
Medication: Blood pressure	0.3	0.5	1.1	1.1	-0.4	0.8	0.0
Angina (self-reported)	1.7	2.2	3.1	1.8	-1.4	1.8	0.7
Migraine (self-reported)	1.1	1.4	2.9	-1.2	0.9	0.5	-1.7
Medication: Ibuprofen	1.3	1.6	3.1	-1.2	1.8	-0.8	-1.0
Medication: Allopurinol	0.5	0.7	1.9	0.6	-0.6	1.4	-0.4
Medication: Omeprazole	0.4	0.5	1.2	-0.4	0.2	0.6	-1.1
Medication: Seretide 50 evohaler	1.6	1.8	2.6	-1.1	1.6	-1.0	-1.5
Mean time to correctly identify matches	0.2	0.3	0.7	-0.8	0.5	-0.4	-0.5
Heart disease (mother)	0.9	1.1	1.7	0.9	-1.2	0.6	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	3.1	0.7	-1.0	1.7	1.8
Whole body fat mass	0.4	1.8	3.7	0.9	-1.3	1.0	1.9
Leg fat mass (right)	0.6	2.5	5.2	1.2	-1.5	1.0	2.3
Arm predicted mass (right)	0.1	0.6	1.0	0.5	-0.9	0.6	1.0
Pulse rate, automated reading	0.2	0.7	2.2	0.2	-0.1	-0.7	1.5
Alcohol intake frequency.	2.4	5.5	8.5	-2.5	2.5	-2.9	-0.9
Comparative height size at age 10	0.1	0.8	1.7	-1.3	0.4	-0.9	-0.8
Number of full sisters	0.5	0.6	2.1	0.3	-0.3	-0.3	1.5
Suffer from ‘nerves’	0.3	0.5	0.7	-0.6	0.8	-0.8	-0.6
Overall health rating	2.0	4.3	7.1	-2.0	1.9	-1.6	-2.7
Chest pain or discomfort	1.7	2.5	5.0	-1.1	1.5	-1.3	-2.2
Had major operations	0.2	0.2	0.4	-0.1	-0.1	-0.6	-0.6
Age at last live birth	0.4	0.6	1.7	-1.3	0.7	-0.3	-0.5
Family relationship satisfaction	1.2	1.4	3.0	-0.0	0.2	1.6	-1.7
Leg pain on walking	1.8	2.3	5.0	1.3	-1.3	1.0	2.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.6	-0.6	0.1	-0.8	-0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	0.2	0.0	-0.4	0.1
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	3.1	1.3	-1.0	0.9	1.8
Medication: Aspirin	0.4	0.5	1.1	1.1	-1.0	0.1	-0.1
Supplements: Vitamin C	0.5	0.6	0.9	-0.9	1.0	-0.6	-0.3
Knee pain experienced in last month	0.5	0.8	1.8	-0.5	1.0	-0.5	-1.3
Hypertension (Self-reported)	0.1	0.3	0.6	0.5	-0.4	0.8	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.9	3.4	8.4	-1.6	1.3	-1.0	-2.9
Illnesses of father: Heart disease	0.3	0.4	0.8	-0.7	0.5	-0.5	-0.9
Illnesses of siblings: Diabetes	2.4	2.9	3.5	-1.5	1.5	-1.9	-1.9
Smoking status: Previous	0.2	0.2	0.7	0.5	0.1	-0.0	0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	3.6	-1.8	1.9	-1.1	-1.0
Whole body fat-free mass	0.2	1.0	2.0	0.6	-1.2	0.7	1.4
Leg fat-free mass (right)	0.2	1.1	2.8	0.3	-1.0	0.5	1.7
Arm fat percentage (left)	0.6	2.6	4.9	1.2	-1.5	1.2	2.2
Average weekly red wine intake	4.8	7.1	10.0	3.2	-3.0	2.5	1.7
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.7	0.4	-0.6	0.8	0.8
Mood swings	1.4	2.6	3.6	-1.6	1.9	-1.3	-1.6
Loneliness, isolation	3.0	4.2	6.2	-2.5	2.0	-1.2	-2.3
Long-standing illness, disability or infirmity	0.2	0.4	0.5	-0.7	0.3	-0.7	-0.6
Ever had bowel cancer screening	0.0	0.0	0.0	-0.0	0.0	-0.1	-0.0
Diabetes diagnosed by doctor	0.3	0.5	0.6	0.7	-0.8	0.4	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.1	0.7	-1.1	-0.2	0.7
Friendships satisfaction	0.7	0.9	2.5	-0.5	0.7	0.6	-1.6
Qualifications: nursing, teaching	0.0	0.0	0.1	0.1	0.1	-0.2	0.1
Commuting to job workplace: Walk	0.5	0.5	1.1	0.6	-0.7	1.0	0.4
Eye problems/disorders: Cataract	0.0	0.0	0.1	0.1	-0.2	0.0	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.0	0.7	-0.6	1.0	0.8
Medication for cholesterol	0.2	0.4	0.6	-0.8	0.6	-0.6	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.9	-1.1	0.3	-1.4	-0.7
Back pain experienced in last month	0.4	0.6	1.5	-0.9	0.4	-0.1	-1.2
Mineral and other dietary supplements	0.7	0.9	2.9	0.7	-0.4	1.7	-0.4
Breast cancer (self-reported)	0.3	0.3	0.8	-0.9	0.4	-0.2	-0.6
Asthma (self-reported)	2.5	4.9	6.4	-2.3	2.5	-1.8	-2.2
Osteoporosis (self-reported)	0.0	0.1	0.1	0.4	-0.2	-0.0	-0.2
Osteoarthritis (self-reported)	0.6	0.8	2.4	-0.8	-0.1	-1.5	-0.5
Medication: Aspirin	0.5	0.6	1.2	1.1	-1.0	0.2	-0.4
Medication: Gliclazide	0.3	0.3	1.2	-0.3	-0.1	-0.1	-1.1
Illnesses of father: None of the above (group 1)	0.4	0.5	1.0	-0.7	1.0	-0.6	0.2
Smoking status: Current	0.1	0.2	0.4	-0.6	0.3	-0.4	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	4.8	-0.0	-0.1	-1.2	2.2
Whole body water mass	0.2	1.0	2.0	0.6	-1.1	0.7	1.4
Leg predicted mass (right)	0.2	1.1	2.8	0.3	-1.1	0.5	1.7
Arm fat mass (left)	0.7	2.8	5.1	1.3	-1.7	1.2	2.3
Number of self-reported non-cancer illnesses	0.3	0.5	1.9	-0.1	-0.2	0.1	-1.4
Average weekly champagne plus white wine intake	1.0	1.4	2.0	1.4	-1.0	1.3	0.9
Miserableness	1.9	3.4	3.9	-2.0	2.0	-1.4	-1.9
Guilty feelings	0.2	0.3	0.7	-0.3	0.2	-0.5	-0.8
Wears glasses or contact lenses	4.9	5.6	8.1	2.3	-2.6	1.5	2.8
Ever taken oral contraceptive pill	0.3	0.3	0.5	-0.7	0.3	0.3	-0.7
Hearing aid user	0.8	0.9	1.7	0.9	-1.3	1.0	0.4
Mother’s age at death	0.1	0.1	0.2	0.3	-0.1	0.2	-0.4
Financial situation satisfaction	0.5	0.6	1.0	-0.8	1.0	-0.2	-0.8
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.9	0.0	0.1	-0.9	-0.4
Commuting to job workplace: Public transport	1.6	2.0	3.6	-1.2	1.4	-1.9	-0.8
Eye problems/disorders: Glaucoma	0.3	0.3	1.1	0.4	0.1	-0.3	-1.1
Medication: Blood pressure	0.3	0.5	1.4	0.7	-1.2	0.3	-0.0
Pain type(s) experienced in last month: Hip pain	2.1	2.6	3.1	-1.6	1.5	-1.6	-1.7
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.6	-0.5	0.3	-1.3	-0.1
High cholesterol (Self-reported)	0.5	0.8	1.6	0.9	-1.3	0.9	0.3
Medication: Bendroflumethiazide	0.1	0.2	0.4	0.2	0.1	-0.6	-0.3
Medication: Paracetamol	0.5	0.7	2.0	-0.6	0.4	-1.4	-0.6
Medication: Lisinopril	0.3	0.4	1.6	0.0	-0.3	-0.1	-1.3
Medication: Atorvastatin	3.5	4.3	5.3	2.3	-2.3	2.3	1.2
Illnesses of father: High blood pressure	0.6	0.8	1.2	1.1	-0.9	1.1	0.3
Alcohol drinker status: Never	4.3	5.2	7.0	-2.2	2.7	-2.6	-1.3
Ever smoked	0.0	0.0	0.1	0.1	0.2	-0.1	-0.2
Basal metabolic rate	0.2	1.2	2.4	0.6	-1.2	0.7	1.5
Leg fat percentage (left)	0.7	2.4	3.5	1.5	-1.6	1.1	1.9
Arm fat-free mass (left)	0.2	0.8	1.4	0.7	-1.0	0.5	1.2
Number of operations (self-reported)	0.1	0.2	0.3	0.5	-0.1	-0.5	0.4
Average weekly beer plus cider intake	2.4	3.4	4.0	-1.9	2.0	-1.5	-2.0
Irritability	0.4	0.7	1.0	-0.4	0.9	-0.9	-1.0
Risk taking	0.2	0.3	0.8	0.1	0.6	0.9	-0.1
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.8	0.8	-0.9	0.2	1.7
Fractured/broken bones in last 5 years	0.7	0.9	1.6	-0.6	0.6	-1.0	-1.3
Age started oral contraceptive pill	1.8	2.3	3.6	-1.5	1.5	-1.9	-1.0
Diastolic blood pressure, automated reading	0.6	1.8	2.9	1.4	-1.7	1.2	0.9
Ever depressed for a whole week	1.6	2.0	2.9	1.2	-1.7	1.4	1.3
Unable to work because of sickness or disability	0.2	0.3	0.7	-0.9	0.4	-0.1	-0.6
Commuting to job workplace: Cycle	1.8	2.2	2.6	1.6	-1.3	1.4	1.6
Myopia	0.2	0.2	0.4	-0.4	0.6	-0.3	0.6
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.5	-1.6	1.3	-1.3	-0.2
Cholesterol lowering medication	0.2	0.2	0.8	0.0	-0.3	0.2	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.5	-0.8	0.5	0.3	-1.2
Pain experienced in last month	0.4	0.7	1.8	0.6	-0.5	0.5	1.3
Supplements: Calcium	0.6	0.7	1.6	-0.4	0.7	-1.3	0.7
Basal cell carcinoma (self-reported)	0.4	0.5	1.1	-1.1	0.5	-0.6	-0.3
Heart attack/myocardial infarction (self-reported)	2.0	2.6	4.1	1.8	-2.0	1.7	0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	-0.1	-0.5	0.3	-0.2
Heart disease (siblings)	0.0	0.1	0.1	0.1	0.2	-0.2	-0.4
Alcohol drinker status: Previous	1.6	1.8	3.3	-1.1	1.8	-1.6	-0.6
Pack years of smoking	0.0	0.0	0.0	0.1	0.1	-0.1	0.1
Impedance of whole body	1.6	7.9	11.5	-3.0	2.7	-2.0	-3.4
Leg fat mass (left)	0.6	2.5	5.0	1.2	-1.5	1.0	2.2
Arm predicted mass (left)	0.2	1.1	1.7	0.8	-1.3	0.8	1.3