Best TWAS P=4.76e-11 · Best GWAS P=7.9e-10 conditioned to 0.626
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DIP2B | 0.11 | 0.10 | enet | 16 | 0.13 | 2.6e-15 | -5.3 | -6.2 | 6.8e-10 | -0.72 | 0.27 | 0.73 | FALSE |
2 | GTEx | Adipose Subcutaneous | ATF1 | 0.07 | 0.05 | enet | 14 | 0.04 | 3.1e-04 | 6.0 | 6.6 | 4.8e-11 | 0.90 | 0.01 | 0.99 | TRUE |
3 | GTEx | Adrenal Gland | DIP2B | 0.16 | 0.05 | lasso | 9 | 0.07 | 2.1e-03 | 6.1 | 5.8 | 6.4e-09 | 0.97 | 0.04 | 0.83 | FALSE |
4 | GTEx | Artery Aorta | ATF1 | 0.26 | 0.29 | lasso | 2 | 0.28 | 1.5e-15 | 6.0 | 6.0 | 1.9e-09 | 0.88 | 0.01 | 0.99 | FALSE |
5 | GTEx | Artery Coronary | ATF1 | 0.20 | 0.09 | lasso | 4 | 0.05 | 1.2e-02 | 6.0 | 6.2 | 5.9e-10 | 0.91 | 0.02 | 0.93 | FALSE |
6 | GTEx | Artery Tibial | ATF1 | 0.24 | 0.26 | lasso | 7 | 0.25 | 2.7e-19 | 6.0 | 6.0 | 1.6e-09 | 0.89 | 0.01 | 0.99 | FALSE |
7 | GTEx | Brain Cerebellum | CERS5 | 0.53 | 0.65 | enet | 19 | 0.65 | 6.0e-25 | 4.7 | -5.3 | 1.3e-07 | -0.71 | 0.43 | 0.57 | FALSE |
8 | GTEx | Brain Cortex | CERS5 | 0.26 | 0.09 | enet | 30 | 0.11 | 5.9e-04 | 4.7 | -6.1 | 1.4e-09 | -0.66 | 0.07 | 0.76 | FALSE |
9 | GTEx | Breast Mammary Tissue (Female) | ATF1 | 0.04 | 0.03 | enet | 7 | 0.00 | 2.7e-01 | 5.4 | 6.1 | 8.0e-10 | 0.90 | 0.02 | 0.50 | FALSE |
10 | GTEx | Breast Mammary Tissue (Female) | CERS5 | 0.09 | 0.03 | lasso | 3 | 0.05 | 1.8e-02 | 4.0 | -5.6 | 1.7e-08 | -0.52 | 0.05 | 0.24 | FALSE |
11 | GTEx | Cells Transformed fibroblasts | DIP2B | 0.16 | 0.08 | lasso | 3 | 0.08 | 6.2e-07 | 5.8 | 5.5 | 3.9e-08 | 0.92 | 0.08 | 0.92 | FALSE |
12 | GTEx | Esophagus Gastroesophageal Junction | ATF1 | 0.15 | 0.15 | lasso | 4 | 0.14 | 7.8e-06 | 5.7 | 5.8 | 7.2e-09 | 0.84 | 0.03 | 0.96 | FALSE |
13 | GTEx | Esophagus Muscularis | ATF1 | 0.15 | 0.17 | lasso | 2 | 0.16 | 7.5e-10 | 6.0 | 6.0 | 2.1e-09 | 0.88 | 0.01 | 0.99 | FALSE |
14 | GTEx | Esophagus Muscularis | CERS5 | 0.15 | 0.07 | enet | 18 | 0.09 | 2.7e-06 | 5.2 | -5.6 | 2.4e-08 | -0.78 | 0.06 | 0.94 | FALSE |
15 | GTEx | Heart Atrial Appendage | CERS5 | 0.14 | 0.03 | lasso | 6 | 0.02 | 4.2e-02 | -4.9 | -5.6 | 2.6e-08 | -0.74 | 0.06 | 0.89 | FALSE |
16 | GTEx | Muscle Skeletal | DIP2B | 0.03 | 0.04 | lasso | 6 | 0.04 | 1.1e-04 | 6.0 | 6.0 | 1.8e-09 | 0.88 | 0.01 | 0.98 | FALSE |
17 | GTEx | Muscle Skeletal | ATF1 | 0.09 | 0.06 | lasso | 5 | 0.07 | 5.0e-07 | 6.0 | 6.2 | 5.8e-10 | 0.89 | 0.01 | 0.99 | FALSE |
18 | GTEx | Nerve Tibial | CERS5 | 0.31 | 0.28 | enet | 20 | 0.36 | 2.2e-26 | -4.9 | -5.6 | 2.6e-08 | -0.65 | 0.26 | 0.73 | FALSE |
19 | GTEx | Prostate | CERS5 | 0.19 | 0.08 | lasso | 4 | 0.02 | 1.2e-01 | -4.8 | -5.2 | 1.7e-07 | -0.56 | 0.06 | 0.39 | FALSE |
20 | GTEx | Skin Not Sun Exposed Suprapubic | COX14 | 0.17 | 0.04 | lasso | 5 | 0.03 | 5.4e-03 | 4.7 | 5.2 | 2.2e-07 | 0.76 | 0.05 | 0.82 | FALSE |
21 | GTEx | Skin Sun Exposed Lower leg | ATF1 | 0.07 | 0.07 | lasso | 4 | 0.08 | 6.1e-07 | 5.4 | 5.3 | 1.2e-07 | 0.95 | 0.05 | 0.95 | FALSE |
22 | GTEx | Stomach | DIP2B | 0.09 | 0.09 | lasso | 5 | 0.07 | 4.1e-04 | 5.8 | 6.1 | 1.4e-09 | 0.92 | 0.02 | 0.90 | FALSE |
23 | GTEx | Testis | SMARCD1 | 0.22 | 0.10 | enet | 22 | 0.10 | 2.6e-05 | -4.1 | 5.3 | 9.8e-08 | 0.39 | 0.33 | 0.55 | FALSE |
24 | GTEx | Whole Blood | DIP2B | 0.12 | 0.08 | lasso | 4 | 0.08 | 5.7e-08 | 5.8 | 5.8 | 6.0e-09 | 0.91 | 0.06 | 0.93 | FALSE |
25 | YFS | Blood | ATF1 | 0.05 | 0.07 | lasso | 9 | 0.07 | 2.0e-21 | -5.4 | -6.1 | 1.3e-09 | -0.60 | 0.31 | 0.69 | FALSE |
26 | YFS | Blood | DIP2B | 0.36 | 0.27 | bslmm | 385 | 0.28 | 2.8e-90 | 5.8 | -6.2 | 7.7e-10 | -0.89 | 0.04 | 0.96 | FALSE |
27 | YFS | Blood | LIMA1 | 0.04 | 0.06 | enet | 31 | 0.06 | 3.5e-19 | 4.9 | 5.7 | 1.4e-08 | 0.83 | 0.32 | 0.68 | FALSE |
28 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C12orf62 | 0.01 | 0.00 | blup | 47 | 0.00 | 4.6e-02 | 4.7 | 5.3 | 1.2e-07 | 0.65 | 0.02 | 0.53 | FALSE |
29 | The Cancer Genome Atlas | Colon Adenocarcinoma | ATF1 | 0.10 | 0.05 | enet | 18 | 0.06 | 3.5e-04 | 6.0 | 5.9 | 3.1e-09 | 0.86 | 0.01 | 0.98 | FALSE |
30 | The Cancer Genome Atlas | Colon Adenocarcinoma | DIP2B | 0.13 | 0.14 | lasso | 2 | 0.12 | 1.3e-07 | 5.0 | 5.2 | 1.9e-07 | 0.88 | 0.08 | 0.92 | FALSE |
31 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C12orf62 | 0.02 | 0.01 | blup | 47 | 0.01 | 1.7e-02 | 4.7 | 5.2 | 2.1e-07 | 0.64 | 0.02 | 0.53 | FALSE |
32 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ATF1 | 0.03 | 0.04 | lasso | 1 | 0.04 | 6.3e-05 | -5.4 | 5.4 | 6.1e-08 | 0.47 | 0.19 | 0.71 | FALSE |
33 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | DIP2B | 0.11 | 0.02 | blup | 79 | 0.02 | 4.5e-02 | 6.1 | 5.7 | 1.5e-08 | 0.97 | 0.01 | 0.91 | FALSE |