Hub : Genes

ATF1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0290 0.0140 4.8e-03 0.017 0.027 0.012 0.025 0.018 3.5e-03 2.6e-04 1.1e-02 4.6e-04 2.5e-03
2 GTEx Adipose Subcutaneous 0.0730 0.0290 2.9e-04 0.055 NA 0.040 NA 0.039 2.9e-05 NA 3.1e-04 NA 3.7e-04
3 GTEx Artery Aorta 0.2610 0.0690 2.7e-09 0.293 NA 0.261 NA 0.276 1.5e-16 NA 1.3e-14 NA 1.5e-15
4 GTEx Artery Coronary 0.1980 0.0810 2.9e-03 0.092 NA 0.035 NA 0.045 5.3e-04 NA 2.5e-02 NA 1.2e-02
5 GTEx Artery Tibial 0.2426 0.0586 1.6e-13 0.260 NA 0.223 NA 0.246 2.2e-20 NA 2.2e-17 NA 2.7e-19
6 GTEx Breast Mammary Tissue 0.0690 0.0340 8.5e-03 0.073 NA 0.028 NA 0.043 1.3e-04 NA 1.3e-02 NA 2.9e-03
7 GTEx Breast Mammary Tissue (Male) 0.0453 0.0674 2.8e-01 -0.013 NA -0.004 NA 0.009 9.0e-01 NA 4.1e-01 NA 1.9e-01
8 GTEx Breast Mammary Tissue (Female) 0.0430 0.0443 2.0e-01 0.035 NA 0.002 NA -0.003 3.3e-02 NA 2.7e-01 NA 4.0e-01
9 GTEx Esophagus Gastroesophageal Junction 0.1450 0.0540 1.3e-04 0.150 NA 0.105 NA 0.143 4.4e-06 NA 1.2e-04 NA 7.8e-06
10 GTEx Esophagus Muscularis 0.1490 0.0500 1.0e-05 0.168 NA 0.142 NA 0.158 2.1e-10 NA 5.6e-09 NA 7.5e-10
11 GTEx Muscle Skeletal 0.0933 0.0381 6.2e-05 0.056 NA 0.024 NA 0.066 3.2e-06 NA 1.9e-03 NA 5.0e-07
12 GTEx Skin Sun Exposed Lower leg 0.0680 0.0260 6.8e-05 0.068 NA 0.053 NA 0.077 2.5e-06 NA 3.2e-05 NA 6.1e-07
13 GTEx Whole Blood 0.0670 0.0270 1.7e-04 0.089 NA 0.060 NA 0.072 1.3e-08 NA 3.1e-06 NA 3.5e-07
14 NTR Blood 0.0563 0.0144 0.0e+00 0.068 0.066 0.068 0.064 0.068 4.4e-21 2.0e-20 4.0e-21 6.7e-20 7.4e-21
15 YFS Blood 0.0523 0.0138 0.0e+00 0.071 0.059 0.067 0.066 0.068 4.0e-22 1.3e-18 4.1e-21 1.4e-20 2.0e-21
16 TCGA Colon Adenocarcinoma 0.0990 0.0480 9.6e-05 0.045 0.053 0.056 NA 0.055 1.3e-03 4.9e-04 3.5e-04 NA 4.1e-04
17 TCGA Brain Lower Grade Glioma 0.0348 0.0181 6.2e-04 0.040 0.024 0.031 NA 0.035 2.0e-05 8.0e-04 1.7e-04 NA 6.2e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Bipolar Disorder (2018) 1.1 1.7 5.9 -0.9 -1.1 -0.9 -1.0 -0.8 -0.9 -0.2 -1.6 -1.4 -1.0 -1.1 -1.3 0.5 1.8 2.4 -0.7 -2.4
Bipolar Disorder or Schizophrenia 3.5 8.5 21.4 -1.3 -2.9 -2.5 -2.6 -2.4 -2.4 -0.0 -2.9 -3.3 -2.6 -2.9 -2.7 2.9 4.0 4.6 -1.6 -4.5
Depressed Affect (Nagel 2018) 0.6 1.3 5.7 1.3 0.7 0.5 0.5 0.5 0.1 -2.4 1.1 0.6 0.6 0.8 1.1 -0.8 -1.5 -1.8 0.9 1.8
Depression (Nagel 2018) 0.3 0.5 3.3 -1.1 -0.3 0.1 0.0 0.0 0.6 0.3 -0.4 0.1 0.1 -0.0 0.5 1.8 1.1 0.9 -0.1 -1.2
Intelligence (Savage-Jansen 2018) 0.9 2.7 6.6 -1.0 1.7 1.6 1.8 1.6 1.9 -0.7 1.9 2.3 1.6 1.6 2.6 -0.2 -0.9 -1.7 1.6 1.6
Neuroticism (Nagel 2018) 0.3 0.6 6.7 1.0 0.2 0.0 0.1 -0.1 -0.8 -2.6 0.6 0.1 0.0 0.1 0.4 -0.3 -0.4 -0.5 0.6 0.6
Schizophrenia (2018) 3.6 7.4 15.8 -0.9 -2.9 -2.4 -2.5 -2.4 -2.3 0.1 -2.4 -3.0 -2.6 -2.8 -2.4 3.3 3.7 4.0 -1.5 -3.9
Schizophrenia vs Biploar Disorder 4.8 6.4 10.5 -0.7 -3.2 -3.0 -3.0 -2.9 -2.0 1.8 -2.0 -2.7 -2.9 -3.0 -2.3 3.2 2.0 2.3 -2.5 -1.9
Worry (Nagel 2018) 1.2 2.5 5.1 0.1 -1.5 -1.6 -1.5 -1.6 -2.3 -1.7 -1.5 -1.7 -1.7 -1.8 -1.4 0.9 1.6 2.0 -1.0 -1.8
Alzheimer’s Disease (in mother) 0.3 0.3 1.2 0.3 -0.2 0.3 0.0 0.1 -0.3 -1.1 0.1 0.9 0.4 0.3 0.2 0.9 -1.1 -0.5 -0.6 0.3
Alzheimer’s Disease (in father) 0.3 0.3 1.0 1.0 0.3 0.5 0.4 0.5 -0.2 -0.7 0.2 0.7 0.6 0.6 0.1 -0.3 -0.7 -0.7 0.0 0.4
Alzheimer’s Disease (including proxy) 0.3 0.4 1.6 0.5 -0.4 0.3 -0.1 0.1 -0.4 -1.0 -0.0 0.9 0.4 0.3 0.1 1.3 -0.9 -0.3 -0.9 -0.1
Crohns Disease (2017) 1.9 4.2 7.7 0.5 2.1 2.0 2.0 2.0 2.3 0.9 2.3 1.7 2.0 2.4 2.2 -1.5 -2.4 -2.8 1.9 2.4
Irritable Bowel Disease (IBD) 1.4 3.3 5.3 0.4 2.0 1.9 1.9 2.1 2.3 1.5 1.9 1.3 1.8 2.1 1.8 -1.2 -1.3 -2.2 2.1 1.9
Ulcerative Colitis (UC) 0.8 1.4 3.1 -0.2 1.4 1.4 1.4 1.6 1.8 1.6 1.1 0.7 1.2 1.3 1.0 -0.2 0.2 -0.8 1.7 0.6
Major Depression (MDD) 0.5 0.7 1.8 0.5 -0.8 -0.8 -0.8 -0.8 -1.1 -0.3 -0.6 -0.9 -0.8 -0.8 -1.1 1.3 0.9 0.6 -0.1 -0.3
Reaction Time 0.8 1.4 3.9 0.8 -1.3 -1.1 -1.1 -1.1 -1.2 0.5 -1.0 -1.4 -1.1 -1.0 -1.2 1.7 1.1 1.1 -2.0 -1.0
Verbal and Numeric Reasoning (VNR) 0.4 1.0 2.6 -0.9 1.1 0.8 1.0 0.8 1.1 -1.0 1.1 1.6 0.9 0.9 1.6 0.4 -0.6 -0.9 0.7 0.8
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.5 0.6 2.3 -0.5 -0.7 -0.3 -0.4 -0.3 -0.9 -0.5 -0.6 -0.5 -0.3 -0.4 -0.8 1.5 1.4 1.2 -0.1 -1.4
Prostate Cancer 0.6 0.9 7.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 2.8
Age at First Birth 0.4 0.6 4.0 -2.0 0.1 0.3 0.4 0.3 1.0 0.7 0.4 0.3 0.3 0.2 0.5 1.1 1.0 0.8 0.0 -0.9
Bipolar Disorder (2011) 1.2 1.1 5.2 -1.0 -0.4 -0.2 -0.2 -0.2 -0.8 -1.3 -1.0 -0.6 -0.3 -0.5 -0.5 1.0 1.6 2.3 -0.3 -2.3
Body Mass Index (BMI) (2010) 0.1 0.1 0.7 -0.8 0.1 0.2 0.3 0.1 0.3 -0.2 -0.2 0.6 0.2 0.2 0.6 0.5 -0.2 0.0 0.1 -0.2
Coronary Artery Disease (CAD) 1.0 1.2 3.0 -0.2 1.2 0.9 0.9 0.9 1.3 0.1 0.8 1.2 1.0 0.9 1.6 -1.7 -1.7 -1.0 0.7 0.9
Crohns Disease (2012) 3.7 5.9 10.4 -0.7 2.6 2.4 2.5 2.5 3.2 0.7 2.9 2.6 2.5 2.7 3.2 -1.5 -2.3 -2.6 2.5 2.1
Mean Putamen Volume 0.4 0.5 4.0 0.4 -0.1 -0.0 -0.0 0.0 -1.2 -2.0 0.0 -0.3 -0.1 -0.0 -0.6 0.8 0.6 0.5 0.0 -0.6
Fasting Glucose 0.6 0.7 1.4 -0.4 0.9 1.2 1.2 1.2 0.7 -1.0 0.8 1.2 1.2 1.0 0.5 0.2 0.1 -0.3 1.0 0.2
HbA1C 2.1 2.3 6.0 0.0 1.6 1.6 1.6 1.5 1.8 -0.2 1.9 1.8 1.7 1.6 2.4 -1.4 -1.4 -1.4 1.0 1.1
HDL Cholesterol 0.8 1.3 3.2 -0.5 1.3 1.5 1.3 1.2 1.0 -0.3 1.3 1.7 1.5 1.4 1.8 -0.1 -0.6 -0.9 0.4 0.9
LDL Cholesterol 1.1 1.7 4.9 1.1 1.3 1.1 1.0 1.1 1.3 0.4 1.2 1.1 1.1 1.3 1.4 -1.6 -1.1 -2.2 1.1 1.8
Lupus 1.0 1.5 5.2 -1.4 -0.9 -0.5 -0.7 -0.5 -0.8 1.6 -1.1 -0.6 -0.5 -0.9 -1.1 0.4 1.7 2.3 -1.2 -2.2
Neuroticism (2016) 0.3 0.5 3.8 -0.7 -0.2 -0.1 -0.1 -0.2 -0.6 -2.0 0.3 -0.0 -0.1 -0.2 0.4 1.1 0.8 0.7 0.2 -0.9
Primary Biliary Cirrhosis 1.6 2.3 5.8 0.3 -1.6 -1.1 -1.3 -1.1 -2.4 -1.7 -1.9 -1.1 -1.2 -1.4 -1.9 2.3 1.3 1.5 -1.6 -1.1
Rheumatoid Arthritis 0.4 0.5 3.4 1.1 0.4 0.6 0.5 0.7 -0.4 -1.9 0.2 0.4 0.6 0.6 0.1 -0.9 -0.6 0.0 0.1 -0.2
Schizophrenia (2014) 4.3 9.4 18.2 -0.3 -3.5 -3.1 -3.3 -3.0 -2.6 -0.2 -2.7 -3.6 -3.2 -3.6 -2.8 3.1 3.5 4.3 -2.1 -4.0
Triglycerides 1.6 2.7 5.7 -0.4 1.7 1.7 1.6 1.8 2.4 1.9 1.6 1.7 1.7 1.6 1.9 -1.3 -1.0 -1.4 1.9 1.4
Type 2 Diabetes (T2D) (2012) 0.4 0.4 1.8 -1.4 -0.4 -0.2 -0.0 -0.2 0.4 0.4 0.3 -0.3 -0.2 -0.2 0.6 0.6 1.0 0.9 -0.4 -1.3
Ulcerative Colitis 0.9 1.3 3.9 -0.7 1.3 1.1 1.4 1.4 2.0 1.0 1.3 0.9 1.1 1.0 1.3 0.4 0.4 -0.7 1.8 0.5
Blood Eosinophil Count 1.7 13.4 29.9 3.4 3.8 3.3 3.1 3.2 2.1 -0.5 2.8 3.4 3.3 3.6 3.2 -4.3 -5.5 -5.4 2.8 5.2
Blood Platelet Count 9.1 105.9 171.6 7.4 11.6 10.9 10.9 10.8 7.9 -1.6 10.0 10.2 10.9 11.7 9.1 -10.3 -10.8 -13.1 10.3 12.2
Blood Red Count 1.4 13.0 24.1 -0.0 -4.6 -4.5 -4.7 -4.5 -2.6 2.0 -4.0 -4.2 -4.5 -4.4 -3.7 2.7 1.3 2.3 -4.9 -1.6
Blood White Count 10.7 79.6 116.6 0.6 10.4 10.2 10.2 10.1 8.9 -1.0 10.5 10.0 10.2 10.5 10.8 -6.0 -7.6 -8.7 9.5 7.3
Heel T-Score 4.7 37.4 56.1 2.3 -7.3 -7.1 -7.2 -7.1 -7.5 -1.9 -6.5 -7.0 -7.1 -6.8 -7.2 4.4 3.5 4.8 -7.4 -3.6
BMI 0.2 1.2 7.3 -0.4 0.1 0.2 -0.0 -0.0 0.2 -1.9 -0.1 1.0 0.3 0.4 0.9 0.4 -2.7 -1.7 -0.8 1.7
Height 3.0 58.1 111.2 -3.3 -8.5 -7.5 -7.3 -7.5 -5.6 -0.1 -6.8 -7.7 -7.5 -8.3 -6.8 8.8 9.5 10.5 -6.6 -10.3
Waist Hip Ratio (WHR) 0.1 0.6 2.3 0.8 0.3 0.0 0.1 0.0 0.0 1.5 -0.9 0.5 0.1 0.3 0.0 -1.2 -1.2 -1.4 0.2 1.4
Systolic Blood Pressure 5.4 26.9 57.8 -3.5 -5.0 -5.7 -5.2 -5.5 -2.8 -1.9 -3.1 -5.7 -5.7 -6.2 -2.4 5.3 6.7 7.6 -4.2 -7.1
Smoking Status 0.2 0.4 2.0 0.9 0.6 0.5 0.7 0.6 0.6 0.2 1.0 -0.0 0.4 0.6 0.3 0.2 0.2 -0.3 1.4 0.2
Allergy or Eczema 0.6 1.6 5.8 -2.4 0.9 1.2 1.3 1.2 1.4 1.0 1.6 1.0 1.2 0.9 1.2 0.4 1.1 0.9 1.8 -1.1
Cardiovascular Disease 2.2 7.2 13.2 -0.6 -2.6 -3.2 -2.8 -3.1 -2.4 -2.7 -2.3 -3.1 -3.2 -3.6 -1.9 1.9 3.0 3.3 -1.7 -2.6
Hypothyroidism (self reported) 0.9 2.0 6.5 -2.5 1.3 1.4 1.3 1.4 2.1 -0.0 1.3 1.6 1.4 1.3 2.5 0.3 0.0 0.1 1.1 -0.6
Respiratory disease 0.4 0.8 5.3 -0.9 0.1 0.6 0.6 0.6 -0.9 -2.3 -0.0 0.3 0.6 0.4 -0.1 1.4 1.3 1.0 -0.1 -1.0
Type 2 Diabetes (T2D) (2018) 2.2 4.2 9.9 -3.1 1.8 2.2 2.1 2.1 3.0 1.7 2.1 2.5 2.2 1.9 3.0 0.2 0.0 0.1 2.0 -0.8
Lung FEV1/FVC ratio 0.1 0.7 4.1 0.7 -0.3 -0.3 -0.7 -0.5 -1.1 -0.5 -0.7 0.5 -0.1 -0.2 -0.4 -0.6 -2.0 -1.3 -0.9 1.4
Lung FVC 5.2 26.4 44.5 -0.4 6.0 5.3 5.7 5.4 5.9 0.2 6.7 5.5 5.4 5.6 5.9 -3.6 -3.8 -5.6 5.8 5.0
Neuroticism 0.3 0.8 9.2 0.1 0.5 0.4 0.5 0.4 -0.1 -3.0 1.0 0.6 0.4 0.4 1.1 0.3 -0.6 -0.5 0.6 0.5
Chronotype (morning person) 0.8 1.9 11.5 -3.4 -0.9 -0.4 -0.4 -0.5 0.6 0.5 -1.1 -0.1 -0.4 -1.0 -0.2 1.7 1.4 2.1 -1.3 -2.2
Hair Pigment 0.3 8.8 15.3 1.2 -3.1 -3.7 -3.7 -3.7 -3.2 0.6 -3.7 -3.5 -3.7 -3.8 -3.4 1.1 0.9 1.9 -3.9 -1.2
Tanning 0.3 4.0 7.1 -2.0 2.1 2.3 2.3 2.3 2.7 1.3 1.4 2.6 2.3 2.3 2.4 -0.3 -1.1 -1.5 2.0 1.1
Hand grip strength (left) 1.4 3.6 8.5 -2.2 1.8 2.0 2.1 1.9 2.9 1.7 2.5 2.4 2.1 1.8 2.3 -0.2 -0.9 -1.1 1.7 0.7
Number of treatments/medications taken 0.9 1.7 5.6 -1.2 -0.7 -0.9 -0.8 -0.7 0.5 -1.1 0.3 -1.2 -0.9 -1.0 1.1 1.6 2.4 2.1 0.5 -2.3
Average weekly spirits intake 0.8 0.9 2.1 -0.1 1.5 1.1 1.2 1.1 0.8 -0.1 0.2 1.2 1.1 1.1 0.6 -1.3 -0.4 -0.9 1.3 0.9
Sensitivity / hurt feelings 0.3 0.5 3.7 0.8 -0.4 -0.7 -0.7 -0.7 -0.9 -1.9 0.2 -0.5 -0.7 -0.5 0.1 -0.4 -0.9 -0.1 -0.5 0.0
Frequency of depressed mood in last 2 weeks 0.6 0.8 5.4 -1.8 -0.6 -0.2 -0.2 -0.2 0.3 -0.1 -0.6 0.1 -0.2 -0.3 0.3 2.3 1.1 1.1 -0.3 -1.3
Hearing difficulty/problems: Yes 1.1 1.6 4.8 2.2 -1.1 -1.3 -1.3 -1.3 -1.9 -1.5 -0.5 -1.7 -1.4 -1.3 -1.7 -0.0 0.6 0.4 -0.8 0.1
Relative age of first facial hair 1.3 2.7 8.3 -0.2 2.0 2.1 2.2 2.2 1.4 0.9 1.9 1.6 2.0 1.9 0.9 -0.6 0.7 -0.7 2.9 0.3
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.9 -0.1 0.5 0.3 0.4 0.4 0.5 -0.7 0.6 0.2 0.2 0.3 0.6 0.2 0.0 -0.8 0.8 1.0
Ever used hormone-replacement therapy (HRT) 1.2 1.5 2.7 1.2 -1.4 -1.6 -1.6 -1.6 -0.9 -0.2 -1.4 -1.6 -1.6 -1.4 -1.2 -0.1 -0.4 0.3 -1.6 0.1
Ever had hysterectomy (womb removed) 2.1 2.3 5.1 -0.4 -1.6 -1.5 -1.6 -1.6 -1.6 -0.2 -2.2 -1.1 -1.4 -1.7 -2.0 1.0 1.1 1.7 -2.1 -1.6
Systolic blood pressure, automated reading 4.2 12.1 24.3 -1.4 -3.4 -4.0 -3.8 -3.9 -2.5 -1.6 -2.1 -4.0 -4.0 -4.3 -1.9 2.3 3.9 4.9 -3.6 -4.6
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 1.1 0.3 -0.1 0.1 -0.1 0.1 0.5 1.0 -0.2 -0.0 0.1 -0.0 0.2 0.3 0.1 0.4 -0.3 -0.4
Angina 0.3 0.4 1.6 0.0 0.8 0.6 0.7 0.7 0.4 0.6 0.0 0.5 0.6 0.7 0.5 -0.2 0.2 -0.6 1.3 0.6
Medication for hormone replacement therapy 1.2 1.3 3.8 1.9 -1.0 -1.3 -1.3 -1.3 -1.4 -1.5 -0.7 -1.2 -1.3 -1.0 -1.1 -0.6 -0.7 -0.6 -0.8 0.8
Vitamin and mineral supplements 1.0 1.3 2.9 -0.9 1.3 1.5 1.3 1.4 0.8 1.7 0.9 1.4 1.4 1.4 0.8 -0.7 -0.7 -0.7 0.7 0.6
Supplements: Zinc 0.3 0.3 0.9 -0.5 0.2 0.2 0.1 0.2 0.9 0.8 0.9 0.3 0.2 0.1 0.7 -0.6 -0.8 -0.4 -0.1 0.5
Medication: Co-codamol 2.3 2.7 5.4 -2.0 1.5 2.0 1.9 1.9 2.3 0.3 0.9 2.2 2.0 1.8 2.3 -0.1 -0.4 -0.3 1.8 -0.3
Medication: Metformin 1.7 2.4 5.6 -2.2 1.5 1.7 1.7 1.7 2.3 0.4 1.4 1.6 1.7 1.6 2.4 0.2 0.6 0.5 1.4 -1.2
Diabetes (father) 0.2 0.2 0.7 -0.5 0.2 0.4 0.4 0.4 -0.2 -0.8 0.2 0.6 0.5 0.2 0.2 0.5 -0.1 -0.3 0.6 0.5
Diabetes (mother) 0.1 0.1 0.5 -0.1 -0.0 -0.4 -0.3 -0.4 0.5 -0.3 0.1 -0.2 -0.3 -0.2 0.7 -0.5 -0.4 0.1 -0.7 -0.1
Severe depression (siblings) 0.8 0.9 2.1 -0.3 1.5 1.2 1.2 1.2 0.8 0.1 0.2 1.0 1.1 1.0 1.0 -1.2 0.2 0.2 1.5 -0.6
Pack years adult smoking proportion 0.3 0.4 5.0 -0.0 -0.3 -0.5 -0.4 -0.5 0.5 2.2 0.4 -0.6 -0.5 -0.4 -0.1 -0.0 -0.2 -0.2 -0.4 0.4
Impedance of leg (right) 7.8 37.8 78.7 -1.9 -6.6 -5.8 -5.9 -5.7 -5.9 -0.3 -6.3 -6.4 -5.9 -6.6 -6.3 5.6 8.0 8.9 -4.8 -8.2
Leg fat-free mass (left) 0.1 0.6 1.5 -0.8 0.5 0.6 0.6 0.5 0.7 -1.2 0.4 1.1 0.7 0.6 1.0 0.7 -1.1 -0.7 -0.1 0.4
Trunk fat percentage 4.6 18.3 27.7 -1.0 -4.9 -4.5 -4.7 -4.5 -4.0 -2.1 -5.1 -4.4 -4.5 -4.7 -3.6 3.9 3.5 5.3 -4.5 -5.0
Hand grip strength (right) 0.6 1.7 5.7 -2.4 0.9 1.1 1.2 1.1 2.1 1.9 1.2 1.5 1.2 1.0 1.4 0.8 0.2 0.1 1.4 -0.4
Townsend deprivation index at recruitment 0.4 0.6 3.2 -0.2 -0.9 -0.2 -0.4 -0.2 -0.8 -0.1 -1.1 -0.4 -0.2 -0.3 -1.0 1.8 1.0 0.7 -0.5 -1.1
Current tobacco smoking 2.8 4.7 8.2 0.8 2.4 1.8 2.1 1.9 2.6 0.2 2.8 1.7 1.8 2.2 2.7 -1.5 -2.3 -2.9 2.5 2.7
Average weekly fortified wine intake 1.3 1.5 3.8 0.3 1.6 1.1 1.2 1.2 1.3 0.6 1.4 0.8 1.0 1.3 1.3 -1.9 -0.7 -1.3 1.7 1.1
Maternal smoking around birth 0.7 1.0 4.7 2.2 -0.6 -0.8 -0.9 -0.9 -1.0 0.1 -1.1 -0.8 -0.8 -0.5 -1.0 -0.6 -1.2 -1.1 -0.3 1.3
Fed-up feelings 0.5 0.9 2.4 0.3 0.6 0.5 0.6 0.5 0.7 -1.4 0.9 0.9 0.6 0.7 1.2 0.0 -1.6 -1.5 0.5 1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 2.8 -1.3 -0.2 0.3 0.3 0.3 0.7 1.1 -0.4 0.3 0.3 0.3 0.3 1.7 1.0 0.9 0.1 -1.1
Relative age voice broke 3.1 4.7 9.3 -1.7 2.8 2.8 2.9 2.8 2.2 0.8 1.6 3.1 2.9 2.6 2.2 -1.4 -0.6 -0.8 2.4 0.3
Taking other prescription medications 0.2 0.3 1.7 0.0 0.3 0.1 0.2 0.2 0.5 -0.9 1.0 -0.1 0.1 0.2 1.3 0.5 0.6 -0.1 0.8 -0.1
Age when periods started (menarche) 0.7 1.8 4.7 1.9 -1.6 -1.4 -1.5 -1.4 -2.2 -1.0 -1.1 -1.6 -1.4 -1.2 -1.3 0.6 0.3 0.7 -1.0 -0.8
Bilateral oophorectomy (both ovaries removed) 2.7 3.1 5.0 -0.7 -2.1 -1.8 -1.8 -1.8 -1.6 -0.1 -2.2 -1.8 -1.8 -1.9 -2.1 1.9 1.8 1.9 -1.7 -1.7
Heel bone mineral density (BMD) T-score, automated (left) 4.3 9.7 15.5 1.2 -3.8 -3.6 -3.8 -3.7 -3.9 -1.7 -3.1 -3.5 -3.6 -3.5 -3.7 2.1 1.7 2.5 -3.5 -1.9
Tinnitus: Yes, but not now, but have in the past 2.5 2.6 5.4 0.0 1.8 1.5 1.4 1.4 1.4 0.2 2.0 1.5 1.5 1.5 1.7 -2.3 -2.2 -1.9 1.5 1.9
Qualifications: CSEs or equivalent 1.0 1.4 5.7 -1.1 -0.8 0.0 -0.1 0.1 -0.7 -0.8 -1.4 -0.3 -0.0 -0.1 -0.6 2.4 2.1 1.8 0.1 -2.1
Serious illness, injury or assault to yourself 1.5 1.8 6.2 1.1 1.3 1.2 1.3 1.2 0.4 -2.5 1.2 1.0 1.1 1.3 1.1 -0.6 -0.8 -1.6 1.9 1.6
High blood pressure 4.1 11.5 20.2 -2.0 -3.3 -4.0 -3.5 -3.8 -1.8 -2.8 -2.2 -4.0 -4.0 -4.2 -1.3 3.4 4.2 4.5 -2.2 -4.2
Hayfever, allergic rhinitis or eczema 0.4 0.9 2.7 -1.2 0.9 1.1 1.3 1.2 0.8 -0.2 1.4 0.7 1.1 0.9 0.7 -0.1 0.7 0.6 1.6 -0.6
Multivitamins +/- minerals 0.9 1.2 2.3 0.4 -1.3 -1.2 -1.2 -1.2 -1.0 -1.1 -1.5 -1.0 -1.2 -1.3 -1.0 1.0 0.8 0.9 -0.9 -0.9
Stomach or abdominal pain in last month 0.6 0.7 2.1 0.2 0.9 0.8 0.9 0.8 0.4 -0.6 0.8 0.9 0.8 0.8 0.5 -1.0 -1.0 -1.3 0.5 1.4
Supplements: Glucosamine 0.1 0.1 0.7 -0.9 0.1 0.2 0.2 0.1 0.4 -0.0 -0.0 0.3 0.2 0.2 0.2 -0.3 0.4 0.5 0.1 -0.7
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 1.9 -0.9 0.8 1.4 1.1 1.4 1.0 1.0 0.9 1.0 1.3 1.1 1.1 0.4 0.4 0.0 1.0 -0.4
Medication: Atenolol 2.7 3.3 5.6 0.6 -2.1 -2.3 -2.2 -2.3 -1.5 0.6 -2.1 -2.4 -2.3 -2.1 -1.7 2.0 1.2 1.2 -1.8 -1.0
Medication: Levothyroxine sodium 1.0 1.6 3.3 -0.1 1.6 1.5 1.4 1.5 1.1 -1.0 1.8 1.4 1.5 1.5 1.7 -1.0 -0.9 -0.6 1.1 0.4
Sitting height 3.5 25.1 41.5 -2.2 -5.5 -5.4 -5.3 -5.5 -3.9 -0.5 -4.4 -5.3 -5.4 -5.9 -4.9 4.7 5.3 6.4 -5.1 -6.0
Chronic bronchitis/emphysema (father) 0.9 1.0 1.8 -1.0 -1.0 -0.8 -0.9 -0.7 -1.0 -0.6 -0.9 -1.0 -0.9 -1.0 -0.7 1.1 1.3 1.3 -1.1 -1.4
High blood pressure (mother) 1.2 1.6 4.4 -0.0 -1.1 -1.6 -1.5 -1.6 -1.3 -1.5 -1.3 -1.0 -1.5 -1.6 -0.5 0.3 0.2 1.1 -2.1 -1.3
Body mass index (BMI) 0.1 0.5 3.4 -0.2 0.0 -0.0 -0.1 -0.1 0.2 -1.4 -0.4 0.6 0.0 0.2 0.7 0.1 -1.8 -1.1 -0.6 1.0
Impedance of leg (left) 8.5 41.1 80.1 -1.6 -7.0 -6.1 -6.2 -6.0 -6.2 -0.1 -6.7 -6.7 -6.2 -6.9 -6.7 5.8 8.0 9.0 -5.3 -8.3
Leg predicted mass (left) 0.1 0.6 1.6 -0.8 0.5 0.6 0.5 0.4 0.7 -1.2 0.4 1.1 0.7 0.6 1.0 0.7 -1.2 -0.7 -0.2 0.4
Trunk fat mass 3.1 13.5 20.5 -1.4 -4.3 -3.8 -4.0 -3.9 -3.2 -1.7 -4.3 -3.6 -3.8 -4.0 -3.0 3.8 2.9 4.5 -4.1 -4.4
Waist circumference 0.1 0.5 2.4 -0.6 -0.8 -0.7 -0.8 -0.7 -0.3 -0.5 -1.5 -0.3 -0.6 -0.6 -0.1 1.3 -0.1 0.5 -0.9 -0.7
Number of incorrect matches in round 0.4 0.7 2.3 0.9 -0.9 -0.4 -0.5 -0.3 -0.5 1.4 -0.2 -1.1 -0.4 -0.5 -0.9 0.6 1.5 0.9 -0.5 -0.9
Past tobacco smoking 1.2 2.2 5.5 -1.0 1.5 1.6 1.4 1.5 1.0 -0.3 1.0 2.4 1.7 1.6 1.7 -1.1 -2.1 -1.6 0.2 1.4
Alcohol usually taken with meals 5.9 9.5 16.8 1.0 3.5 2.9 3.0 2.8 2.7 -0.2 3.4 3.1 2.9 3.2 3.1 -4.1 -3.9 -3.9 2.7 3.4
Nervous feelings 0.3 0.6 3.2 0.4 -0.6 -0.7 -0.7 -0.7 -1.3 -1.8 -0.4 -0.7 -0.8 -0.8 -0.7 -0.2 0.4 0.7 -0.0 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 4.1 0.8 -0.3 -0.0 -0.1 0.0 -1.2 -2.0 -0.7 -0.0 -0.0 -0.2 -0.5 1.0 0.4 0.1 0.0 -0.0
Hearing difficulty/problems with background noise 0.4 0.7 2.1 -0.1 1.0 0.8 1.0 0.8 0.6 -1.1 1.4 0.9 0.9 0.8 1.3 -0.1 0.0 -0.1 0.9 0.1
Hair/balding pattern: Pattern 2 0.6 0.7 2.2 -1.2 -0.6 -0.1 -0.3 -0.1 -0.2 0.6 -1.3 -0.2 -0.2 -0.1 -0.2 1.5 1.3 1.3 -0.4 -1.5
Had menopause 0.2 0.2 0.8 0.8 -0.1 -0.4 -0.4 -0.5 -0.1 0.2 0.3 -0.3 -0.4 -0.0 0.4 -0.2 -0.9 -0.7 -0.5 0.8
Had other major operations 0.3 0.4 4.4 -0.8 -0.5 -0.4 -0.4 -0.4 0.7 2.1 0.2 -0.1 -0.4 -0.3 0.1 0.6 0.4 0.1 -0.3 -0.1
Forced vital capacity (FVC) 0.3 1.0 3.2 -1.8 0.7 1.1 1.2 1.1 1.0 -0.6 1.2 1.3 1.2 0.8 1.0 0.9 0.6 0.3 0.9 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 4.6 10.6 19.3 2.8 -3.9 -3.8 -4.0 -3.9 -4.4 -2.1 -3.2 -3.6 -3.8 -3.6 -4.0 1.5 0.5 1.5 -3.9 -0.8
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.5 1.2 -0.3 -0.6 -0.6 -0.5 -0.1 -1.1 0.6 -0.7 -0.7 -0.4 0.5 -0.4 -0.7 -0.6 0.3 0.7
Qualifications: None of the above 2.2 4.6 9.2 1.9 -2.3 -2.4 -2.4 -2.3 -2.3 1.0 -2.7 -3.0 -2.5 -2.3 -3.0 0.6 2.0 1.4 -1.6 -1.1
Financial difficulties in last 2 years 4.5 6.1 11.2 1.7 -2.9 -3.3 -3.2 -3.3 -2.6 -1.7 -1.9 -3.2 -3.3 -3.1 -2.2 1.1 0.6 1.0 -2.7 -0.5
Mouth/teeth dental problems 0.5 0.8 3.5 -1.7 -0.3 -0.0 -0.1 -0.1 0.3 -0.9 0.8 0.4 0.1 -0.3 1.1 1.3 0.4 1.5 -0.6 -1.9
Heart attack 1.0 1.3 4.3 1.8 0.9 0.7 0.7 0.7 -0.1 -0.7 0.7 0.7 0.8 1.0 0.3 -1.0 -1.8 -2.0 0.8 2.1
Allergy 0.8 1.9 3.9 1.0 -1.4 -1.7 -1.8 -1.7 -0.6 2.0 -1.7 -1.4 -1.6 -1.4 -1.2 0.1 -0.4 -0.2 -1.9 0.2
Pain all over the body in last month 0.4 0.5 2.4 -0.9 -0.0 -0.1 0.1 0.0 -0.0 -0.4 -0.7 -0.2 -0.2 -0.1 0.3 0.8 1.6 1.1 0.6 -1.3
Diabetes (self-reported) 2.1 3.2 8.9 -3.0 1.6 1.9 1.8 1.9 2.5 0.6 1.4 1.8 1.9 1.6 2.5 0.3 0.8 0.9 1.9 -1.6
Hayfever/allergic rhinitis (self-reported) 1.1 1.4 2.3 -0.3 1.5 1.3 1.3 1.3 0.7 -1.3 1.2 1.4 1.4 1.1 1.5 -1.2 -0.9 -0.4 1.5 0.6
Medication: Ramipril 1.9 2.4 6.6 -2.6 1.2 1.3 1.6 1.4 1.6 -0.3 1.1 1.1 1.3 1.2 2.0 2.2 1.8 0.8 1.8 -1.3
Medication: Simvastatin 0.1 0.2 0.8 0.4 -0.0 -0.2 -0.2 -0.2 0.1 -0.7 -0.0 -0.2 -0.2 -0.2 0.6 0.9 0.4 -0.1 0.7 0.0
Fluid intelligence score 0.4 0.7 2.0 -0.0 0.7 0.7 0.7 0.6 0.4 -1.4 0.8 1.3 0.8 0.9 1.2 0.5 -1.1 -1.1 0.1 0.9
Illnesses of siblings 2.2 3.0 5.1 0.3 1.9 1.9 1.9 1.8 1.4 1.2 1.6 2.1 1.9 2.1 1.5 -1.2 -2.1 -2.3 1.5 1.9
Neuroticism score 0.2 0.5 5.4 0.0 -0.3 -0.4 -0.2 -0.4 -0.6 -2.3 0.3 -0.2 -0.4 -0.3 0.4 0.9 0.2 0.3 0.3 -0.2
Weight 0.8 3.9 8.1 -1.3 -2.3 -1.9 -2.0 -2.0 -1.5 -1.4 -2.4 -1.5 -1.9 -2.0 -1.3 2.8 1.3 2.3 -2.4 -2.4
Impedance of arm (right) 4.9 22.8 47.5 0.0 -5.0 -4.5 -4.7 -4.4 -5.4 -2.5 -4.5 -5.1 -4.6 -5.2 -5.0 3.4 5.6 6.9 -3.7 -6.4
Arm fat percentage (right) 1.0 4.1 7.1 -0.3 -2.3 -2.2 -2.3 -2.2 -2.1 -2.7 -2.4 -1.9 -2.1 -2.2 -1.4 1.7 0.7 2.1 -2.4 -1.9
Trunk fat-free mass 0.1 0.5 2.3 -1.5 0.3 0.5 0.5 0.3 1.1 0.5 0.3 1.1 0.6 0.5 0.7 1.2 -0.3 -0.4 -0.0 0.0
Hip circumference 1.0 4.1 11.3 -2.2 -1.9 -1.3 -1.4 -1.4 -1.2 -1.3 -2.2 -1.2 -1.3 -1.6 -1.0 3.4 2.3 3.1 -1.9 -3.4
Time employed in main current job 0.3 0.3 1.7 -0.1 0.1 -0.1 -0.2 -0.2 0.6 0.5 0.3 0.5 -0.0 -0.1 0.5 -0.7 -1.1 -1.0 -0.5 1.3
Alcohol intake versus 10 years previously 1.3 1.9 4.4 -1.2 -1.7 -1.4 -1.5 -1.4 -0.9 -0.2 -2.1 -1.0 -1.4 -1.5 -1.0 1.3 1.4 1.4 -1.9 -1.4
Father’s age at death 1.8 2.4 6.3 1.2 -1.6 -1.7 -1.7 -1.7 -2.1 -0.4 -2.3 -1.8 -1.8 -1.5 -2.5 -0.2 0.5 0.6 -1.6 -0.3
Worrier / anxious feelings 0.2 0.3 0.9 -0.6 -0.3 -0.2 -0.2 -0.2 -0.9 -0.6 -0.2 -0.1 -0.2 -0.5 -0.2 0.9 0.5 0.9 -0.3 -0.9
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 4.9 0.5 -0.7 -0.8 -0.7 -0.8 -1.3 -2.2 -0.8 -0.7 -0.8 -0.7 -0.6 0.7 0.1 0.5 -1.0 -0.3
Falls in the last year 1.9 2.6 5.9 -1.2 1.8 1.9 1.8 1.9 2.2 -0.3 1.9 1.8 1.9 1.9 2.4 -0.8 -0.8 -0.9 1.3 0.3
Hair/balding pattern: Pattern 3 6.1 9.1 19.6 3.0 3.2 2.8 2.8 2.9 2.2 -0.5 3.4 2.2 2.8 3.1 2.4 -4.4 -2.9 -3.8 3.1 3.8
Number of live births 0.7 1.0 3.0 0.6 -1.3 -1.2 -1.3 -1.1 -0.8 1.7 -0.5 -1.5 -1.2 -0.9 -0.8 0.5 -0.2 0.4 -1.0 -0.5
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 4.4 -2.1 0.7 1.1 1.1 1.0 0.7 -0.4 0.9 1.7 1.2 0.7 1.0 0.7 -0.1 0.2 0.6 -0.4
Pulse rate 0.2 0.4 3.8 -1.9 0.2 0.3 0.4 0.3 0.9 0.4 0.2 0.5 0.4 0.1 0.5 0.4 0.0 0.5 0.2 -0.6
Happiness 1.0 1.3 3.8 1.0 0.8 1.0 0.9 1.0 0.8 0.6 0.8 1.1 1.1 1.2 0.9 -0.6 -1.6 -1.8 0.9 2.0
Noisy workplace 0.8 1.0 2.9 -1.5 0.9 1.0 1.0 1.0 1.5 1.7 0.6 1.0 1.0 0.9 0.8 -0.4 0.7 0.3 0.9 -0.8
Qualifications: A levels/AS levels or equivalent 1.8 3.9 6.0 0.3 2.4 2.2 2.3 2.2 1.3 -1.0 2.4 2.2 2.2 2.3 1.7 -1.3 -1.9 -2.2 2.1 2.0
Serious illness, injury or assault of a close relative in last 2 years 1.8 2.1 6.9 0.6 1.7 1.5 1.7 1.6 1.3 -0.3 1.5 1.2 1.4 1.6 1.4 -0.7 -0.5 -1.5 2.6 1.4
Mouth/teeth dental problems: Dentures 0.4 0.7 3.2 1.8 -0.7 -0.7 -0.7 -0.7 -0.8 0.9 -1.1 -1.0 -0.8 -0.5 -1.3 0.3 0.4 -0.5 -0.3 0.7
Asthma 0.4 0.7 6.7 -0.7 0.4 0.6 0.8 0.7 -0.4 -2.6 0.9 0.5 0.6 0.6 0.7 0.7 0.8 0.3 0.5 -0.3
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 2.6 -1.0 0.3 0.5 0.7 0.6 0.3 0.3 -0.1 0.4 0.5 0.6 0.1 1.6 1.3 0.9 0.8 -1.3
Medication: Cholesterol lowering 1.2 1.8 3.8 -0.0 1.6 1.5 1.5 1.5 1.2 -0.5 1.7 1.6 1.5 1.5 2.0 0.3 -0.9 -1.3 1.6 1.0
Depression (self-reported) 0.4 0.4 1.3 -0.7 -0.7 -0.6 -0.6 -0.6 -0.5 -0.4 0.1 -0.6 -0.6 -0.7 -0.2 0.8 0.6 1.1 -0.0 -1.1
Medication: Lansoprazole 2.0 2.3 4.3 -0.8 1.6 2.0 1.8 2.0 1.0 -1.7 0.8 2.0 2.0 1.9 1.8 -0.6 -0.6 -0.3 2.1 0.0
Prospective memory result 1.5 1.8 5.1 -1.1 1.3 1.2 1.2 1.3 2.3 1.4 1.7 0.9 1.2 1.2 1.8 -1.1 -0.2 -0.6 2.2 0.5
Lung cancer (father) 0.5 0.6 1.9 -1.0 0.3 0.4 0.7 0.5 0.8 -0.1 0.0 0.2 0.4 0.5 1.0 1.4 1.1 0.8 0.4 -1.4
Illnesses of mother 2.0 2.4 5.1 -0.8 1.7 2.2 2.0 2.1 0.7 0.3 1.3 2.3 2.2 2.0 0.7 -0.5 -0.7 -1.3 1.8 1.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.3 5.7 -2.4 1.3 1.8 1.8 1.7 1.4 -0.7 1.6 2.4 1.9 1.5 1.8 0.7 -0.2 -0.1 1.3 -0.3
Pulse wave Arterial Stiffness index 2.4 2.8 5.4 0.9 -2.2 -2.1 -2.3 -2.1 -1.6 0.4 -1.1 -2.3 -2.2 -2.2 -1.6 0.5 0.7 1.2 -1.8 -0.9
Impedance of arm (left) 4.0 18.7 39.4 0.0 -4.6 -4.1 -4.2 -4.0 -4.7 -2.1 -4.1 -4.7 -4.2 -4.7 -4.3 3.3 5.2 6.3 -3.4 -5.9
Arm fat mass (right) 0.7 3.0 5.4 -0.5 -2.1 -1.8 -2.0 -1.9 -1.6 -2.3 -2.1 -1.4 -1.8 -1.8 -1.1 1.9 0.4 1.6 -2.3 -1.5
Trunk predicted mass 0.1 0.5 2.3 -1.5 0.3 0.5 0.5 0.4 1.1 0.5 0.3 1.1 0.6 0.5 0.7 1.1 -0.3 -0.4 0.0 0.0
Standing height 2.7 27.0 58.1 -2.6 -5.6 -4.6 -4.6 -4.7 -4.0 -0.1 -4.8 -4.7 -4.6 -5.3 -4.7 6.3 6.8 7.6 -4.5 -7.6
Length of working week for main job 0.3 0.3 1.6 1.2 -0.1 -0.1 -0.1 -0.1 -0.3 0.0 -1.0 0.0 -0.1 -0.0 -0.6 0.1 -0.4 -1.0 -0.2 1.0
Exposure to tobacco smoke at home 0.8 0.9 2.6 -0.3 0.6 0.7 0.6 0.6 1.1 1.4 1.0 1.0 0.8 0.9 0.8 -0.0 -1.6 -1.5 -0.4 1.3
Breastfed as a baby 1.5 1.8 2.9 -0.1 -1.7 -1.6 -1.5 -1.6 -0.5 1.2 -0.6 -1.7 -1.6 -1.5 -0.8 1.5 1.5 1.3 -1.2 -1.6
Tense / ‘highly strung’ 1.2 1.9 4.5 0.0 -1.3 -1.5 -1.4 -1.5 -1.4 -1.0 -1.1 -1.6 -1.5 -1.7 -1.1 0.3 1.5 2.1 -0.9 -1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 3.5 -0.5 -1.4 -1.2 -1.3 -1.2 -1.0 -1.5 -0.5 -1.2 -1.2 -1.4 -0.5 1.7 1.1 1.8 -0.5 -1.9
Hair/balding pattern: Pattern 4 11.9 28.9 43.3 0.8 6.6 6.0 6.2 6.0 4.9 -0.7 6.1 5.8 6.0 6.2 5.3 -4.2 -4.6 -6.1 5.9 5.4
Birth weight of first child 2.4 4.4 13.4 2.8 1.8 1.4 1.3 1.3 0.5 -1.1 1.9 1.7 1.5 1.7 0.9 -2.4 -3.7 -3.4 0.9 3.5
Peak expiratory flow (PEF) 0.5 1.1 7.5 -2.7 -0.2 0.2 0.2 0.1 0.3 -0.7 -0.3 0.9 0.3 -0.3 0.4 1.6 1.1 1.5 0.2 -1.6
Pulse wave reflection index 2.0 2.4 8.9 3.0 -1.4 -1.8 -1.9 -1.7 -1.6 -0.7 0.1 -1.9 -1.8 -1.6 -1.3 -0.6 -1.0 -0.9 -1.4 1.6
Ever highly irritable/argumentative for 2 days 0.5 0.6 2.3 0.9 -0.6 -0.5 -0.8 -0.6 -0.8 -1.5 -1.5 -0.1 -0.5 -0.5 -0.5 0.3 -1.2 -0.3 -0.5 0.5
Loud music exposure frequency 2.0 2.2 4.2 0.9 1.5 1.6 1.5 1.7 0.6 -2.1 1.1 1.5 1.6 1.4 1.1 -1.2 -1.5 -1.6 1.5 1.9
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 3.5 0.0 1.2 1.1 1.2 1.0 0.4 -1.4 0.5 1.7 1.2 1.2 1.3 -0.7 -1.9 -1.2 0.9 0.9
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.3 0.8 -0.6 -0.5 -0.6 -0.5 -0.9 0.6 -0.8 -0.9 -0.6 -0.3 -1.2 -0.8 -0.3 -0.3 -0.6 0.5
Blood clot in the leg (DVT) 1.1 1.5 3.8 -0.3 1.1 1.5 1.3 1.4 0.7 -0.1 0.3 2.0 1.6 1.7 1.2 -0.2 -1.4 -1.5 0.5 1.2
Medication: Paracetamol 0.3 0.5 2.1 -1.3 -0.4 -0.5 -0.2 -0.4 0.4 -0.1 0.1 -0.6 -0.5 -0.4 0.5 1.4 1.2 1.0 0.1 -1.0
Headache pain in last month 0.4 0.7 2.2 -1.2 0.7 0.4 0.8 0.5 0.9 -0.9 1.4 0.6 0.4 0.7 1.5 0.3 -0.0 -0.6 1.0 0.4
Medication for cholesterol, blood pressure or diabetes 1.2 2.1 7.8 1.2 1.0 1.0 0.8 0.9 0.4 1.0 1.0 0.9 1.0 1.2 0.0 -2.8 -2.5 -2.2 0.4 2.4
Glaucoma (self-reported) 0.3 0.4 1.9 0.1 0.5 0.4 0.5 0.4 0.5 -0.8 1.4 0.5 0.4 0.3 1.2 -0.0 -0.3 -0.5 0.4 0.3
Gout (self-reported) 1.3 1.8 4.1 -0.2 -1.7 -1.4 -1.5 -1.4 -0.9 -0.7 -0.3 -1.7 -1.4 -1.5 -0.9 2.0 1.3 1.6 -1.5 -1.3
Hypothyroidism/myxoedema (self-reported) 1.2 2.4 6.0 -1.3 1.7 1.7 1.6 1.7 1.9 -0.3 2.1 1.8 1.7 1.7 2.4 -0.6 -0.9 -0.7 1.6 0.4
Medication: Amlodipine 4.5 6.3 13.0 -1.1 -2.6 -2.6 -2.5 -2.4 -1.2 -1.8 -2.2 -3.0 -2.7 -2.7 -1.0 2.8 3.4 3.6 -1.7 -3.6
Medication: Ventolin 100micrograms inhaler 0.1 0.2 1.0 -1.0 -0.1 -0.0 0.1 0.1 0.2 0.1 -0.7 -0.1 -0.1 -0.1 -0.2 -0.2 0.8 0.6 0.2 -0.4
Birth weight 0.2 0.4 2.7 1.6 -0.1 -0.2 -0.2 -0.2 0.1 0.8 0.4 -0.2 -0.2 0.1 -0.1 -0.1 -0.9 -1.0 0.0 1.0
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.6 0.8 1.0 0.9 0.9 1.0 1.1 0.5 1.1 0.3 0.8 1.1 0.4 -0.8 -0.4 -0.9 1.3 0.8
High blood pressure (siblings) 2.5 3.6 5.6 -0.3 -2.1 -2.2 -2.1 -2.2 -1.3 -1.8 -1.4 -2.4 -2.3 -2.3 -1.3 1.6 2.1 2.4 -1.2 -1.9
Forced vital capacity (FVC), Best measure 0.5 1.8 7.2 -2.7 0.8 1.4 1.5 1.4 1.4 -0.2 1.4 1.6 1.4 1.0 1.4 1.3 1.0 0.7 1.3 -1.1
Body fat percentage 3.4 13.4 20.3 -1.0 -4.3 -3.9 -4.1 -3.9 -3.5 -2.0 -4.5 -3.7 -3.9 -4.1 -3.0 3.4 2.6 4.3 -4.1 -4.0
Leg fat percentage (right) 2.0 7.4 11.7 -0.8 -3.2 -2.9 -3.1 -3.0 -2.6 -1.8 -3.4 -2.6 -2.9 -3.0 -2.1 2.8 1.7 3.0 -3.1 -2.8
Arm fat-free mass (right) 0.1 0.5 2.9 -1.7 -0.1 0.1 0.1 -0.0 0.9 0.7 -0.3 0.7 0.2 0.1 0.5 1.6 -0.3 -0.2 -0.6 -0.2
Exposure to tobacco smoke outside home 0.3 0.4 1.0 1.0 -0.8 -0.7 -0.7 -0.7 -0.5 -0.3 -0.7 -1.0 -0.8 -0.4 -0.7 0.9 0.0 -0.2 -0.5 0.3
Comparative body size at age 10 2.9 8.0 19.9 2.1 2.7 2.6 2.4 2.5 1.4 -0.8 2.4 3.0 2.6 2.9 1.9 -2.8 -4.4 -4.5 2.0 4.4
Number of full brothers 0.1 0.1 0.9 -0.4 -0.3 0.1 -0.2 0.1 0.1 0.2 0.1 0.1 0.1 -0.1 0.1 0.6 -0.2 0.2 -1.0 -0.1
Worry too long after embarrassment 1.0 1.6 4.2 1.6 1.4 1.0 1.1 1.0 0.1 -1.8 2.0 0.9 1.0 1.0 1.0 -1.6 -1.0 -1.1 1.7 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 2.8 0.7 -0.9 -0.7 -0.8 -0.7 -1.1 -1.7 0.1 -0.8 -0.7 -0.7 -0.5 1.5 0.6 0.5 0.1 -0.6
Wheeze or whistling in the chest in last year 0.6 1.0 4.5 1.3 0.8 0.9 1.0 1.0 -0.2 -2.1 0.6 0.7 0.9 1.2 0.8 0.4 -0.6 -1.1 0.8 1.0
Number of children fathered 0.9 1.0 4.4 -1.0 -0.7 -0.2 -0.2 -0.1 -0.2 0.0 -0.8 -0.6 -0.3 -0.3 -0.5 1.8 2.1 1.7 0.2 -1.8
Reason for reducing amount of alcohol drunk: Health precaution 4.1 4.8 8.1 -0.3 -2.4 -2.5 -2.3 -2.4 -2.0 -0.8 -1.5 -2.8 -2.5 -2.5 -2.3 1.7 2.3 2.7 -2.0 -2.4
Age at first live birth 0.5 0.8 4.0 -1.7 -0.6 -0.3 -0.2 -0.4 -0.1 -0.5 -0.4 0.1 -0.3 -0.4 -0.2 2.0 1.2 1.3 -0.7 -1.6
Pulse wave peak to peak time 1.4 1.6 3.6 -1.0 1.7 1.7 1.9 1.6 1.1 -0.4 0.6 1.9 1.7 1.7 1.1 -0.0 -0.1 -0.6 1.3 0.3
Health satisfaction 1.2 1.5 7.2 2.3 0.4 0.2 0.1 0.3 -0.3 -0.7 1.0 0.2 0.2 0.4 0.5 -0.4 -2.0 -2.4 0.9 2.7
Shortness of breath walking on level ground 0.4 0.5 2.2 0.9 0.2 0.3 0.2 0.3 -0.1 -0.6 0.5 0.3 0.3 0.4 0.3 -0.3 -1.3 -1.3 0.2 1.5
Qualifications: College or University degree 2.2 7.0 13.5 -1.0 3.3 3.2 3.2 3.2 2.4 0.3 3.7 3.2 3.2 2.8 2.3 -1.8 -1.6 -2.1 3.0 2.1
Eye problems/disorders: None of the above 0.1 0.1 0.4 -0.3 -0.1 -0.3 -0.2 -0.2 -0.4 -0.6 0.6 -0.6 -0.3 -0.1 -0.3 -0.1 -0.0 0.0 0.2 0.1
Mouth/teeth dental problems: Loose teeth 1.1 1.3 3.0 -0.4 1.2 1.2 1.3 1.2 1.7 1.2 1.2 0.9 1.1 1.2 1.4 -0.2 -0.6 -1.0 1.2 1.1
Emphysema/chronic bronchitis 1.6 1.8 3.2 0.3 1.8 1.6 1.6 1.5 0.7 -0.5 1.3 1.5 1.6 1.6 1.0 -1.2 -1.0 -1.3 1.8 1.1
Medication for pain relief, constipation, heartburn 0.6 1.1 3.5 0.4 -1.1 -0.9 -1.1 -1.0 -1.6 -0.8 -1.3 -0.5 -0.8 -1.0 -1.7 -0.1 -0.5 0.1 -1.9 0.2
Neck or shoulder pain in last month 1.0 1.4 3.7 -1.9 0.8 1.3 1.3 1.4 1.0 -0.0 0.5 1.1 1.3 1.1 1.0 1.6 1.2 0.5 1.6 -0.8
Medication: Blood pressure 3.0 5.4 13.6 -1.7 -2.0 -2.0 -1.8 -2.0 -1.0 -1.3 -1.9 -2.1 -2.0 -2.2 -0.8 3.7 3.4 3.5 -1.3 -3.6
Angina (self-reported) 0.3 0.4 1.7 0.2 0.8 0.7 0.8 0.7 0.2 0.1 0.1 0.5 0.6 0.8 0.5 -0.3 0.1 -0.8 1.3 0.7
Migraine (self-reported) 0.8 1.0 5.0 -0.3 -0.7 -0.4 -0.4 -0.4 -0.9 -1.0 -0.7 -0.4 -0.4 -0.4 -0.9 2.2 1.8 1.3 -0.2 -1.6
Medication: Ibuprofen 0.8 0.9 2.8 -1.2 0.5 0.7 0.9 0.8 0.4 0.0 0.2 0.5 0.7 0.7 0.3 1.6 1.7 1.1 1.1 -1.5
Medication: Allopurinol 1.1 1.4 3.9 -1.6 -1.2 -0.8 -0.9 -0.8 0.3 0.7 -0.3 -0.9 -0.8 -1.0 -0.2 2.0 1.4 1.8 -1.2 -1.9
Medication: Omeprazole 0.5 0.5 1.4 -0.2 0.6 0.8 0.6 0.8 0.5 -0.0 0.8 0.9 0.9 1.0 1.2 0.1 -0.7 -0.9 0.8 0.7
Medication: Seretide 50 evohaler 0.4 0.5 1.9 1.0 0.0 -0.4 -0.4 -0.4 -0.1 -1.2 0.8 -0.3 -0.4 -0.4 0.2 -1.4 -0.8 -0.6 -0.3 0.9
Mean time to correctly identify matches 0.6 1.1 3.4 0.9 -1.2 -1.1 -1.1 -1.1 -0.6 1.1 -0.5 -1.5 -1.1 -0.9 -0.8 1.1 0.8 0.8 -1.8 -0.7
Heart disease (mother) 0.3 0.4 1.6 0.9 0.5 -0.2 0.1 -0.1 0.6 -0.3 0.8 -0.7 -0.3 -0.0 0.5 -1.3 -0.2 -0.7 0.8 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.1 2.1 1.5 -1.1 -1.2 -1.3 -1.2 -0.9 -0.1 -0.5 -1.2 -1.2 -1.1 -1.3 -0.1 -0.9 -0.6 -1.4 1.0
Whole body fat mass 2.1 8.6 13.1 -1.2 -3.4 -3.1 -3.2 -3.1 -2.5 -1.7 -3.6 -2.7 -3.0 -3.2 -2.2 3.1 1.9 3.4 -3.5 -3.3
Leg fat mass (right) 1.3 4.9 8.3 -1.0 -2.6 -2.3 -2.5 -2.4 -1.9 -1.9 -2.8 -1.9 -2.3 -2.4 -1.5 2.5 1.0 2.4 -2.9 -2.3
Arm predicted mass (right) 0.1 0.4 2.8 -1.7 -0.3 -0.1 -0.1 -0.2 0.7 0.6 -0.5 0.5 0.0 -0.1 0.4 1.5 -0.2 -0.0 -0.8 -0.3
Pulse rate, automated reading 0.4 1.3 9.9 -3.1 -0.0 0.3 0.4 0.2 1.8 2.0 0.4 0.8 0.4 0.1 1.0 0.9 0.4 0.7 0.3 -1.0
Alcohol intake frequency. 0.2 0.5 2.9 -0.1 -0.7 -0.4 -0.4 -0.4 -0.9 -1.5 -0.7 -0.2 -0.4 -0.3 -0.4 1.7 0.6 0.2 -0.7 -0.4
Comparative height size at age 10 1.5 8.3 20.4 -2.1 -3.0 -2.3 -2.3 -2.3 -1.7 0.0 -2.5 -2.4 -2.3 -2.7 -2.1 3.8 4.4 4.5 -2.4 -4.5
Number of full sisters 0.5 0.6 1.8 -0.9 0.8 0.9 0.9 0.8 0.3 -1.4 0.3 1.2 1.0 0.8 1.1 -0.0 -0.7 0.1 0.2 -0.4
Suffer from ‘nerves’ 0.5 0.8 8.6 0.1 -0.4 -0.4 -0.4 -0.5 -1.0 -2.9 -0.3 -0.2 -0.4 -0.3 0.2 1.0 0.1 0.8 0.2 -0.8
Overall health rating 0.1 0.3 1.8 -0.0 -0.0 0.2 0.2 0.2 -0.6 -1.4 -0.6 0.2 0.2 0.1 0.1 1.2 0.4 0.3 0.2 -0.5
Chest pain or discomfort 0.6 0.8 4.0 -0.3 0.9 0.9 1.2 0.9 0.5 -1.0 0.7 0.8 0.8 0.9 0.9 0.7 0.5 -0.4 2.0 0.3
Had major operations 0.4 0.5 3.0 -1.7 0.5 0.4 0.6 0.4 1.0 0.5 0.1 0.7 0.5 0.3 0.9 -0.1 0.2 0.6 0.7 -0.9
Age at last live birth 1.0 1.5 4.0 -1.8 -1.2 -1.0 -0.8 -1.1 -0.5 -0.1 -0.9 -0.5 -0.9 -1.1 -0.3 2.0 1.2 1.6 -1.4 -1.8
Family relationship satisfaction 0.8 1.0 2.8 -0.3 1.0 0.9 1.0 0.9 1.4 0.3 1.7 0.8 0.9 0.9 1.7 -0.3 -0.8 -0.9 1.0 1.1
Leg pain on walking 2.4 3.1 7.0 0.5 1.7 1.8 1.7 1.9 1.2 -0.3 1.4 1.8 1.8 2.0 1.5 -1.8 -1.6 -2.6 1.9 2.6
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 2.0 0.3 -0.9 -0.4 -0.6 -0.6 -1.2 -1.4 -1.2 0.1 -0.3 -0.3 -0.6 1.2 -0.5 0.1 -1.2 0.1
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.9 0.4 -0.5 -0.6 -0.4 -0.6 -0.7 -0.3 -0.1 -0.8 -0.7 -0.6 -0.6 0.9 0.3 0.4 -0.2 -0.2
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 2.0 -0.5 0.6 0.2 0.3 0.2 0.6 1.2 0.5 0.3 0.2 0.1 0.3 -1.4 -0.0 0.3 0.3 -0.2
Medication: Aspirin 0.5 0.6 2.6 0.0 0.9 0.3 0.5 0.3 1.3 -0.7 1.5 0.1 0.3 0.4 1.6 -0.5 -0.1 -0.4 1.4 0.1
Supplements: Vitamin C 0.4 0.5 2.3 1.5 -0.5 -0.9 -0.7 -0.8 0.0 -1.2 0.4 -1.1 -0.9 -0.6 0.0 -0.4 -0.3 -0.3 0.1 0.2
Knee pain experienced in last month 0.6 0.9 3.2 -1.8 0.1 0.8 0.7 0.7 0.2 -0.3 -0.9 1.1 0.9 0.7 0.5 1.8 0.8 0.9 -0.1 -1.4
Hypertension (Self-reported) 4.5 12.6 21.7 -1.6 -3.6 -4.2 -3.8 -4.0 -2.0 -3.0 -2.3 -4.3 -4.2 -4.4 -1.4 3.6 4.1 4.7 -2.4 -4.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.6 -0.9 0.2 0.3 0.3 0.4 0.2 -0.4 -0.0 0.2 0.3 0.3 0.8 0.8 1.0 1.0 0.6 -1.2
Illnesses of father: Heart disease 0.7 1.0 2.5 0.8 1.2 0.8 1.0 0.8 0.5 -1.6 0.9 0.8 0.8 1.0 0.8 -0.3 -0.8 -1.3 1.6 1.3
Illnesses of siblings: Diabetes 0.2 0.2 0.7 -0.6 0.4 0.5 0.6 0.5 0.7 -0.1 0.5 0.5 0.5 0.6 0.8 0.0 -0.0 -0.1 0.4 0.1
Smoking status: Previous 2.4 3.6 7.1 -0.1 -2.0 -1.9 -1.8 -1.8 -1.4 0.2 -1.8 -2.5 -2.0 -2.0 -2.0 1.9 2.7 2.4 -1.0 -2.4
Forced expiratory volume in 1-second (FEV1), predicted 3.0 6.2 14.6 -1.7 -2.5 -1.9 -1.8 -1.9 -2.3 -0.8 -2.7 -1.9 -1.9 -2.3 -2.3 3.5 3.6 3.8 -1.4 -3.8
Whole body fat-free mass 0.1 0.4 1.7 -1.3 0.2 0.4 0.4 0.3 0.9 -0.1 0.2 0.9 0.5 0.4 0.7 1.1 -0.6 -0.4 -0.2 0.1
Leg fat-free mass (right) 0.1 0.7 1.7 -0.7 0.6 0.7 0.7 0.6 0.9 -1.0 0.6 1.2 0.8 0.8 1.1 0.6 -1.3 -0.9 -0.1 0.5
Arm fat percentage (left) 0.7 2.9 5.7 -0.3 -2.0 -1.9 -2.0 -1.9 -1.6 -2.4 -2.0 -1.6 -1.9 -1.8 -0.9 1.6 0.3 1.5 -2.2 -1.4
Average weekly red wine intake 0.6 0.8 3.4 1.0 0.9 0.9 0.7 0.9 -0.5 -1.8 0.9 0.5 0.8 0.8 0.1 -0.9 -0.8 -0.8 1.0 0.9
Handedness (chirality/laterality): Left-handed 1.1 1.3 2.8 1.1 -1.3 -1.3 -1.3 -1.3 -1.5 -0.4 -1.1 -1.4 -1.3 -1.3 -1.7 0.4 -0.0 0.2 -1.4 0.1
Mood swings 0.6 1.2 5.0 1.4 -0.9 -1.2 -1.1 -1.2 -1.5 -2.2 -0.3 -1.3 -1.2 -0.9 -0.6 0.4 -0.4 -0.1 -0.6 0.4
Loneliness, isolation 0.6 0.9 7.8 1.1 -0.8 -0.5 -0.7 -0.6 -1.3 -2.8 -0.7 -0.1 -0.5 -0.5 -0.3 0.9 -0.6 -0.4 -0.4 0.4
Long-standing illness, disability or infirmity 0.3 0.4 1.1 -0.8 0.7 0.7 0.6 0.8 0.9 -0.2 0.7 0.3 0.6 0.6 1.0 0.1 0.3 -0.3 1.1 0.3
Ever had bowel cancer screening 0.7 0.8 2.1 1.4 -0.7 -1.1 -1.1 -1.1 -0.5 0.4 -0.3 -1.2 -1.1 -0.8 -0.6 -1.4 -0.7 -0.4 -0.5 0.4
Diabetes diagnosed by doctor 1.7 2.8 9.6 -3.1 1.2 1.6 1.5 1.6 2.3 0.5 1.3 1.5 1.6 1.3 2.5 0.6 1.1 1.3 1.6 -1.9
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 4.4 0.4 1.1 0.5 0.7 0.5 2.0 1.1 2.1 0.5 0.4 0.8 1.8 -1.5 -1.4 -1.5 0.7 1.3
Friendships satisfaction 2.6 3.2 10.9 2.3 1.5 1.0 0.9 1.1 0.8 -0.0 1.6 1.0 1.0 1.2 0.9 -2.8 -2.9 -2.8 0.7 3.3
Qualifications: nursing, teaching 3.2 5.0 9.1 0.2 2.7 2.3 2.4 2.4 2.4 -0.1 3.0 1.9 2.2 2.4 2.4 -2.4 -1.8 -2.2 2.6 2.2
Commuting to job workplace: Walk 0.8 0.9 3.4 -1.4 -0.9 -0.4 -0.6 -0.4 -0.7 -0.8 -0.8 -0.2 -0.3 -0.6 -0.7 1.8 1.3 1.3 -0.4 -1.3
Eye problems/disorders: Cataract 0.3 0.3 1.4 0.1 -0.2 -0.1 -0.4 -0.3 -0.4 -0.4 -1.1 0.5 -0.1 -0.3 -0.2 -0.8 -0.8 -0.3 -1.2 0.3
Mouth/teeth dental problems: Mouth ulcers 3.1 4.9 12.5 1.3 2.4 2.0 2.2 2.1 1.8 -0.1 2.0 2.1 2.0 2.3 1.3 -2.2 -2.2 -3.5 2.1 3.5
Medication for cholesterol 2.9 4.3 8.1 0.1 2.4 2.8 2.7 2.7 1.4 1.3 2.0 2.7 2.8 2.8 1.2 -1.2 -1.6 -1.9 1.7 1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.6 7.3 2.7 1.0 0.7 0.7 0.8 -0.2 -2.1 0.4 0.4 0.7 1.1 0.5 -1.3 -1.3 -1.8 1.1 1.7
Back pain experienced in last month 0.1 0.2 0.9 -0.3 0.1 0.2 0.2 0.3 0.8 0.8 -0.2 0.2 0.2 0.3 0.3 0.9 0.5 -0.1 0.3 0.0
Mineral and other dietary supplements 1.3 1.8 5.7 1.5 1.2 1.0 1.0 1.0 0.4 -0.1 0.9 1.0 1.0 1.3 0.6 -1.4 -1.9 -2.4 0.9 2.4
Breast cancer (self-reported) 0.3 0.4 1.2 0.0 0.7 0.8 0.7 0.7 -0.1 -0.9 1.1 0.6 0.8 0.7 0.4 -0.5 -0.1 -0.2 0.3 -0.1
Asthma (self-reported) 0.4 0.8 5.2 -0.9 0.5 0.8 0.9 0.8 -0.4 -2.3 0.8 0.6 0.8 0.7 0.7 0.8 0.9 0.5 0.4 -0.5
Osteoporosis (self-reported) 0.5 0.7 2.2 -0.1 0.7 0.2 0.3 0.2 1.1 0.5 1.5 0.5 0.3 0.4 1.4 -1.5 -1.2 -0.8 0.2 0.8
Osteoarthritis (self-reported) 1.9 2.5 4.7 0.0 1.7 2.0 1.8 2.0 1.3 0.2 0.7 2.2 2.1 2.1 1.8 -0.9 -1.4 -1.7 1.5 1.3
Medication: Aspirin 0.8 1.0 3.7 0.2 1.1 0.6 0.8 0.7 1.4 -1.0 1.9 0.4 0.6 0.8 1.9 -0.4 -0.3 -0.7 1.6 0.4
Medication: Gliclazide 0.6 0.7 2.0 -0.3 0.8 0.8 0.7 0.9 1.4 0.6 0.9 0.8 0.8 1.0 1.2 -0.5 -0.6 -0.8 1.0 0.6
Illnesses of father: None of the above (group 1) 0.5 0.6 6.2 0.1 0.3 0.3 0.3 0.4 1.0 2.5 0.6 -0.1 0.3 0.4 0.2 -1.0 -0.1 -0.1 0.2 -0.2
Smoking status: Current 2.8 4.5 8.5 1.0 2.3 1.8 2.0 1.8 2.4 0.5 2.7 1.7 1.8 2.1 2.3 -1.7 -2.3 -2.9 2.4 2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.2 8.9 12.6 -0.5 3.4 3.4 3.3 3.3 2.9 -0.1 3.5 3.5 3.4 3.4 3.2 -2.7 -2.7 -3.0 2.9 2.6
Whole body water mass 0.1 0.5 1.9 -1.4 0.3 0.5 0.5 0.3 1.0 0.0 0.3 1.0 0.6 0.5 0.8 1.1 -0.6 -0.5 -0.1 0.1
Leg predicted mass (right) 0.1 0.6 1.6 -0.7 0.6 0.7 0.7 0.6 0.8 -1.0 0.6 1.2 0.8 0.8 1.0 0.6 -1.3 -0.9 -0.1 0.5
Arm fat mass (left) 0.6 2.4 4.4 -0.5 -1.9 -1.6 -1.8 -1.7 -1.3 -1.9 -1.9 -1.2 -1.6 -1.6 -0.9 1.8 0.3 1.4 -2.1 -1.3
Number of self-reported non-cancer illnesses 0.5 0.8 2.5 -0.8 -0.3 -0.6 -0.4 -0.5 -0.0 -1.5 -0.1 -0.8 -0.6 -0.6 0.7 1.4 1.6 1.4 0.0 -1.5
Average weekly champagne plus white wine intake 0.6 0.9 3.4 1.1 0.7 0.4 0.4 0.4 0.5 0.5 0.3 0.8 0.5 0.6 0.4 -1.2 -1.9 -1.7 -0.3 1.7
Miserableness 1.4 2.3 4.8 0.8 1.5 1.4 1.3 1.3 1.0 -1.2 1.7 1.5 1.4 1.5 1.6 -1.6 -2.0 -2.1 1.4 2.2
Guilty feelings 1.7 2.6 4.6 -0.7 1.9 2.1 2.0 2.1 1.2 -0.8 2.1 2.1 2.1 1.8 1.6 -0.3 -0.6 -0.8 2.1 0.8
Wears glasses or contact lenses 0.7 0.7 1.8 1.3 -0.6 -1.1 -0.9 -1.1 -0.6 -0.4 -0.7 -1.3 -1.1 -0.9 -0.7 0.1 0.7 0.6 -1.0 -0.5
Ever taken oral contraceptive pill 0.3 0.4 1.7 -0.2 -0.5 -0.4 -0.4 -0.4 -0.6 -1.3 -0.3 -0.6 -0.5 -0.6 -0.4 0.8 0.8 0.6 -0.0 -0.5
Hearing aid user 2.3 2.6 6.7 2.2 -1.2 -1.8 -1.7 -1.7 -2.3 -1.2 -1.6 -1.9 -1.8 -1.7 -2.6 -1.3 0.1 0.2 -1.3 0.4
Mother’s age at death 3.3 4.2 5.9 -1.1 -2.4 -2.2 -2.2 -2.2 -1.4 1.4 -2.4 -2.0 -2.2 -2.2 -2.4 1.8 1.9 2.1 -2.4 -1.8
Financial situation satisfaction 0.7 0.8 3.0 1.7 0.7 0.1 0.4 0.2 -0.1 -0.6 1.2 -0.1 0.0 0.4 0.5 -0.8 -1.1 -1.6 0.6 1.7
Tinnitus: Yes, now most or all of the time 1.0 1.2 2.1 -0.1 -1.1 -1.4 -1.2 -1.3 -0.7 0.8 -1.2 -1.5 -1.4 -1.3 -1.1 0.4 1.3 1.2 -0.6 -0.9
Commuting to job workplace: Public transport 0.5 0.6 2.4 1.1 0.4 0.0 0.1 -0.0 -0.0 -1.6 0.5 0.3 0.1 0.2 0.2 -1.0 -1.1 -1.2 -0.1 1.3
Eye problems/disorders: Glaucoma 0.1 0.2 0.6 -0.4 0.2 -0.0 0.2 -0.0 0.2 -0.8 0.8 0.2 -0.0 -0.1 0.7 0.4 0.5 0.0 0.4 -0.1
Medication: Blood pressure 3.6 6.9 12.2 -0.8 -2.6 -3.3 -2.9 -3.1 -1.4 -1.9 -1.7 -3.5 -3.3 -3.3 -1.1 2.0 3.0 3.3 -1.9 -3.1
Pain type(s) experienced in last month: Hip pain 0.2 0.2 1.0 0.3 0.2 0.2 0.1 0.2 0.6 -0.7 0.5 0.2 0.2 0.4 1.0 0.3 -0.7 -0.7 -0.3 0.5
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.6 -1.2 -0.4 -0.2 -0.2 -0.1 0.4 -0.2 0.0 -0.3 -0.2 -0.4 0.4 1.2 1.2 1.3 0.4 -1.3
High cholesterol (Self-reported) 1.2 2.1 5.8 -1.1 1.7 1.5 1.7 1.5 1.8 -0.4 1.5 1.7 1.6 1.4 2.4 0.0 -0.4 -0.7 2.0 0.5
Medication: Bendroflumethiazide 0.8 1.3 4.6 0.5 -0.6 -1.5 -1.0 -1.3 0.4 -1.4 0.7 -2.2 -1.6 -1.2 0.7 0.3 1.2 1.0 0.2 -1.0
Medication: Paracetamol 0.7 1.0 4.2 -1.8 -0.6 -0.6 -0.4 -0.5 0.3 -0.7 0.3 -0.6 -0.7 -0.6 0.7 2.0 1.6 1.4 -0.1 -1.5
Medication: Lisinopril 0.2 0.3 0.8 0.2 -0.3 -0.8 -0.5 -0.6 0.1 -0.4 -0.2 -0.9 -0.8 -0.7 0.3 0.3 0.6 0.6 -0.2 -0.8
Medication: Atorvastatin 1.6 2.0 5.8 -0.7 1.6 1.2 1.4 1.2 2.1 0.4 2.2 1.4 1.2 1.3 2.4 -0.7 -0.9 -1.0 1.6 0.7
Illnesses of father: High blood pressure 3.6 4.5 14.2 0.1 -2.0 -2.0 -1.9 -2.0 -2.6 -3.8 -2.5 -1.9 -2.0 -2.1 -1.6 1.8 1.9 2.2 -1.9 -1.9
Alcohol drinker status: Never 0.8 1.0 2.2 -1.0 1.2 1.1 1.2 1.0 0.7 -1.5 0.8 1.5 1.1 1.1 1.3 -0.0 0.0 -0.4 1.0 0.0
Ever smoked 1.4 2.5 6.2 0.7 -1.7 -1.8 -1.6 -1.7 -1.0 0.4 -1.2 -2.5 -1.9 -1.9 -1.8 1.2 2.1 1.7 -0.5 -1.5
Basal metabolic rate 0.1 0.4 2.8 -1.3 -0.5 -0.3 -0.3 -0.4 0.2 -0.5 -0.5 0.3 -0.2 -0.3 0.1 1.7 -0.1 0.3 -0.9 -0.6
Leg fat percentage (left) 2.4 8.6 13.8 -0.7 -3.5 -3.2 -3.4 -3.3 -2.8 -1.6 -3.7 -2.9 -3.2 -3.2 -2.4 2.9 1.6 3.1 -3.5 -2.8
Arm fat-free mass (left) 0.1 0.7 3.7 -1.5 -0.8 -0.5 -0.5 -0.6 -0.0 0.3 -1.1 0.1 -0.4 -0.5 -0.4 1.9 0.3 0.6 -1.1 -0.8
Number of operations (self-reported) 0.3 0.4 1.1 -0.1 -0.7 -1.0 -0.9 -1.0 -0.3 0.2 -0.5 -0.8 -1.0 -1.0 -0.5 -0.0 0.2 0.2 -0.6 -0.0
Average weekly beer plus cider intake 4.4 6.3 14.5 -1.1 -2.9 -2.5 -2.5 -2.5 -2.1 0.4 -3.8 -2.3 -2.5 -2.7 -2.7 2.2 2.6 3.0 -2.3 -2.5
Irritability 0.7 1.1 4.4 -0.6 -1.1 -1.0 -0.8 -0.9 -0.9 -0.9 -1.0 -1.1 -1.0 -1.0 -0.7 2.1 1.5 1.1 -0.4 -0.9
Risk taking 1.0 1.4 2.9 1.1 -1.3 -1.7 -1.4 -1.6 -1.1 -0.4 -1.1 -1.7 -1.7 -1.4 -1.0 1.1 0.7 0.5 -1.0 -0.3
Ever had prostate specific antigen (PSA) test 5.0 5.8 11.8 -0.2 2.8 2.6 2.7 2.7 3.1 -0.8 2.7 2.4 2.5 2.7 3.4 -1.8 -1.3 -1.9 3.0 1.4
Fractured/broken bones in last 5 years 0.4 0.5 1.7 -1.0 0.4 0.5 0.6 0.6 0.9 0.2 0.4 0.3 0.5 0.6 1.1 0.6 0.8 0.2 1.3 -0.6
Age started oral contraceptive pill 0.3 0.3 1.3 0.4 -0.0 0.0 -0.0 0.0 0.6 0.8 1.1 -0.1 0.0 0.2 0.4 -0.3 -0.9 -1.0 -0.1 1.1
Diastolic blood pressure, automated reading 7.9 24.4 41.0 -1.2 -5.3 -6.1 -5.7 -6.0 -3.9 -2.6 -3.5 -5.8 -6.1 -6.4 -3.4 3.8 4.5 5.8 -5.0 -5.2
Ever depressed for a whole week 0.6 0.7 3.3 1.8 -0.6 -1.0 -1.1 -0.9 -0.5 -0.9 0.3 -1.2 -1.0 -0.9 -0.2 0.0 -0.5 -0.6 0.0 0.9
Unable to work because of sickness or disability 0.3 0.3 3.9 -0.9 0.0 -0.2 -0.2 -0.1 0.6 2.0 0.1 -0.3 -0.2 -0.4 0.3 -0.4 0.2 0.3 -0.1 -0.2
Commuting to job workplace: Cycle 0.2 0.2 0.8 0.6 -0.5 -0.1 -0.3 -0.1 -0.5 0.4 0.2 -0.4 -0.2 -0.2 -0.9 0.7 0.5 -0.2 -0.1 0.4
Myopia 0.3 0.4 4.0 1.1 0.4 -0.1 0.0 -0.1 -0.7 -2.0 0.3 -0.0 -0.1 -0.1 0.2 -0.7 -0.6 -0.2 -0.2 0.4
Vascular/heart problems diagnosed by doctor 3.1 8.4 13.6 1.4 2.9 3.5 3.0 3.3 1.5 2.7 1.9 3.5 3.5 3.6 1.0 -3.0 -3.7 -3.6 1.7 3.3
Cholesterol lowering medication 0.5 0.8 2.4 0.5 0.7 0.5 0.5 0.5 1.2 -0.9 1.3 0.5 0.5 0.6 1.6 -0.3 -0.6 -1.1 1.3 1.1
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 1.9 0.3 1.0 1.2 1.0 1.2 0.4 -0.3 0.9 1.1 1.2 1.3 1.1 -0.0 -0.7 -1.3 1.4 1.1
Pain experienced in last month 0.4 0.7 1.3 1.1 -0.5 -1.0 -0.9 -1.0 -0.3 1.1 0.1 -1.0 -1.0 -0.9 -0.5 -1.0 -1.1 -0.4 -0.8 0.6
Supplements: Calcium 2.0 2.2 3.7 0.3 -1.7 -1.6 -1.6 -1.5 -1.2 0.3 -0.7 -1.9 -1.6 -1.6 -1.5 1.9 1.3 1.8 -1.7 -1.8
Basal cell carcinoma (self-reported) 0.2 0.3 1.1 0.7 0.1 0.2 0.0 0.2 -0.8 -0.0 -1.1 0.2 0.2 0.2 -0.7 -0.9 -0.6 0.3 -0.3 -0.4
Heart attack/myocardial infarction (self-reported) 1.0 1.3 4.4 1.7 0.9 0.8 0.9 0.8 -0.0 -0.6 0.7 0.8 0.9 1.1 0.4 -0.8 -1.7 -2.1 0.9 2.1
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 3.7 -0.5 1.2 1.6 1.4 1.5 0.7 -0.1 0.3 1.9 1.6 1.7 1.3 -0.0 -1.0 -1.2 0.8 0.9
Heart disease (siblings) 0.6 0.7 2.0 1.0 -1.0 -0.9 -1.0 -0.8 -0.5 -0.1 -0.3 -1.4 -0.9 -1.0 -0.6 0.1 0.9 0.8 -0.9 -0.6
Alcohol drinker status: Previous 2.6 3.0 7.6 0.9 -2.0 -1.5 -1.6 -1.4 -2.3 -1.8 -1.4 -1.8 -1.5 -1.5 -2.0 2.8 1.9 1.6 -1.3 -1.4
Pack years of smoking 0.4 0.6 3.9 0.3 -0.6 -0.8 -0.7 -0.9 0.1 2.0 0.2 -0.9 -0.8 -0.7 -0.4 -0.0 -0.2 -0.2 -0.7 0.5
Impedance of whole body 7.3 37.1 71.1 -0.6 -6.6 -5.9 -6.0 -5.8 -6.4 -1.3 -6.2 -6.5 -6.0 -6.6 -6.4 5.0 7.2 8.4 -5.1 -7.8
Leg fat mass (left) 1.3 5.3 9.0 -0.9 -2.8 -2.5 -2.6 -2.5 -2.0 -1.7 -2.9 -2.0 -2.4 -2.5 -1.7 2.5 1.0 2.4 -3.0 -2.3
Arm predicted mass (left) 0.2 0.8 4.1 -1.7 -0.8 -0.5 -0.5 -0.6 0.1 0.5 -1.1 -0.0 -0.4 -0.5 -0.3 2.0 0.5 0.8 -1.1 -1.0