Best TWAS P=6.46e-13 · Best GWAS P=2.75e-13 conditioned to 0.239
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CCDC117 | 0.03 | 0.01 | blup | 323 | 0.02 | 2.3e-03 | 4.5 | -6.0 | 1.7e-09 | -0.77 | 0.03 | 0.84 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | CCDC117 | 0.10 | 0.01 | lasso | 6 | 0.02 | 2.4e-02 | 7.2 | -7.2 | 6.5e-13 | -0.81 | 0.02 | 0.93 | TRUE |
| 3 | GTEx | Pancreas | XBP1 | 0.15 | 0.13 | lasso | 6 | 0.14 | 1.3e-06 | 4.4 | -5.5 | 4.3e-08 | -0.86 | 0.06 | 0.93 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | CCDC117 | 0.07 | 0.03 | enet | 11 | 0.03 | 2.8e-03 | 7.2 | -6.8 | 9.4e-12 | -0.78 | 0.02 | 0.93 | TRUE |
| 5 | The Cancer Genome Atlas | Lung Adenocarcinoma | CCDC117 | 0.03 | 0.01 | blup | 41 | 0.01 | 2.3e-02 | 6.0 | -6.8 | 1.4e-11 | -0.90 | 0.00 | 0.90 | FALSE |
| 6 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | XBP1 | 0.06 | 0.03 | blup | 35 | 0.06 | 1.6e-03 | 5.1 | -5.6 | 1.8e-08 | -0.87 | 0.01 | 0.73 | FALSE |