Hub : Genes

XBP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Pancreas	0.1490	0.0510	5.5e-05	0.132	NA	0.015	NA	0.143	3.5e-06	NA	7.5e-02	NA	1.3e-06
2	NTR	Blood	0.0280	0.0084	2.9e-08	0.029	0.024	0.021	0.026	0.021	8.4e-10	2.7e-08	2.0e-07	8.2e-09	1.5e-07
3	YFS	Blood	0.1307	0.0257	0.0e+00	0.142	0.197	0.204	0.203	0.201	3.0e-44	2.2e-62	1.1e-64	1.8e-64	1.4e-63
4	TCGA	Brain Lower Grade Glioma	0.0417	0.0263	3.2e-03	0.030	0.017	0.022	NA	0.022	2.4e-04	4.0e-03	1.3e-03	NA	1.4e-03
5	TCGA	Pancreatic Adenocarcinoma	0.0570	0.0330	5.9e-03	0.034	0.060	0.051	NA	0.038	1.4e-02	1.6e-03	3.5e-03	NA	9.9e-03
6	TCGA	Prostate Adenocarcinoma	0.0273	0.0183	3.3e-03	0.017	0.025	0.017	NA	0.023	6.1e-03	1.1e-03	6.1e-03	NA	1.7e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.5	0.9	3.5	-0.8	-0.7	-0.4	1.9	-0.6	-0.4
Bipolar Disorder or Schizophrenia	1.4	3.4	7.8	-2.8	0.6	0.7	1.7	-2.1	-2.2
Depressed Affect (Nagel 2018)	0.1	0.1	0.5	-0.2	0.0	0.0	0.7	-0.1	-0.4
Depression (Nagel 2018)	0.6	0.9	1.6	-1.1	0.8	1.0	0.6	-0.9	-1.3
Intelligence (Savage-Jansen 2018)	1.2	3.6	7.6	1.6	-2.8	-2.6	-0.6	1.6	1.3
Neuroticism (Nagel 2018)	0.6	1.3	2.6	-1.1	1.6	1.2	-0.7	-0.9	-1.2
Schizophrenia (2018)	1.9	3.9	8.6	-2.9	1.3	1.2	0.7	-2.2	-2.5
Schizophrenia vs Biploar Disorder	0.2	0.3	0.9	-0.7	-0.0	0.2	0.4	-0.6	-0.9
Worry (Nagel 2018)	0.8	1.7	2.3	-1.3	1.5	1.3	-1.3	-1.0	-1.4
Alzheimer’s Disease (in mother)	1.2	1.4	2.4	-0.8	1.5	1.5	-1.3	-0.8	-0.9
Alzheimer’s Disease (in father)	0.4	0.5	1.1	-0.6	-0.4	0.4	1.1	-0.7	-0.6
Alzheimer’s Disease (including proxy)	0.6	0.9	2.4	-0.6	0.9	1.5	-1.2	-0.3	-0.4
Crohns Disease (2017)	1.2	2.7	7.1	2.5	0.2	-0.2	-0.3	2.7	1.6
Irritable Bowel Disease (IBD)	0.9	2.2	5.1	2.3	-0.0	-0.3	0.3	2.0	1.9
Ulcerative Colitis (UC)	0.3	0.6	1.4	1.1	-0.6	-0.4	0.3	0.6	1.2
Major Depression (MDD)	1.4	1.7	4.1	0.0	1.8	2.0	-1.6	0.1	-0.7
Reaction Time	0.6	1.1	2.7	1.0	1.1	0.6	-0.7	1.0	1.7
Verbal and Numeric Reasoning (VNR)	1.1	2.6	3.9	2.0	-1.7	-1.9	-0.3	1.6	1.5
Breast Cancer	7.1	17.0	42.1	2.4	-6.5	-5.6	-1.2	3.2	3.3
Ovarian Cancer	2.7	3.5	16.1	-0.2	4.0	2.1	0.4	0.2	-0.6
Prostate Cancer	1.0	1.4	4.3	1.3	2.1	1.3	0.3	0.4	0.6
Age at First Birth	1.2	1.7	5.7	0.6	-2.4	-1.7	0.5	0.2	0.9
Bipolar Disorder (2011)	0.2	0.1	0.4	-0.1	-0.6	-0.6	0.4	-0.2	-0.0
Body Mass Index (BMI) (2010)	1.2	1.7	5.2	1.4	-0.2	-0.3	2.3	1.2	1.2
Coronary Artery Disease (CAD)	1.6	2.0	4.9	0.5	-2.2	-1.8	1.8	0.4	0.6
Crohns Disease (2012)	1.8	3.0	7.4	2.3	-0.3	-0.9	0.0	2.7	2.1
Mean Putamen Volume	0.8	0.9	1.9	-0.5	1.2	1.4	-1.0	-0.1	-0.8
Fasting Glucose	0.7	0.8	1.9	-0.8	-0.2	-0.1	-0.6	-1.4	-1.3
HbA1C	0.2	0.2	0.5	0.6	0.4	0.2	-0.7	-0.3	0.0
HDL Cholesterol	1.7	2.9	4.2	-2.1	1.6	1.4	-1.0	-1.9	-2.0
LDL Cholesterol	0.1	0.2	0.8	0.3	0.1	0.2	-0.9	0.3	0.3
Lupus	0.8	1.3	4.8	0.1	-1.4	-0.7	2.2	-0.0	0.8
Neuroticism (2016)	4.0	5.8	8.2	-2.6	2.6	2.6	-0.9	-2.3	-2.9
Primary Biliary Cirrhosis	0.6	0.9	1.5	-1.1	-0.7	0.7	-0.9	-1.2	-1.0
Rheumatoid Arthritis	1.6	2.3	5.7	1.0	-2.4	-1.7	-0.3	1.2	1.6
Schizophrenia (2014)	3.4	7.5	16.5	-4.1	1.3	1.9	0.7	-3.3	-3.5
Triglycerides	0.7	1.2	2.5	1.6	-0.3	-0.5	1.3	1.1	1.2
Type 2 Diabetes (T2D) (2012)	1.4	1.6	4.0	-1.1	2.0	1.5	-0.5	-1.1	-0.9
Ulcerative Colitis	0.4	0.6	1.9	0.9	0.5	0.6	-0.3	0.6	1.4
Blood Eosinophil Count	0.4	3.2	6.7	-1.4	2.6	2.1	-1.2	-0.8	-2.0
Blood Platelet Count	0.5	6.0	14.1	-1.1	3.8	3.6	-1.5	-0.3	-2.2
Blood Red Count	1.3	12.8	26.6	4.9	0.8	-0.7	2.9	5.2	4.1
Blood White Count	0.3	2.1	6.5	-0.4	-2.5	-2.0	1.3	-0.0	-0.1
Heel T-Score	9.3	74.2	112.4	7.3	-8.5	-9.8	10.6	8.2	6.6
BMI	0.2	1.3	5.4	1.0	0.1	-0.7	2.3	0.6	0.6
Height	0.1	2.6	6.4	-0.8	-1.4	0.0	-2.5	-1.6	-2.0
Waist Hip Ratio (WHR)	2.0	8.8	17.0	2.1	4.1	2.4	3.8	2.9	1.7
Systolic Blood Pressure	2.0	10.0	20.1	-4.5	0.7	1.6	1.1	-4.5	-3.9
Smoking Status	1.9	4.6	10.2	-3.2	1.0	1.1	0.1	-2.9	-2.7
Allergy or Eczema	2.0	5.3	18.2	-1.2	4.3	3.3	0.1	-0.2	-1.1
Cardiovascular Disease	1.2	3.9	8.8	-3.0	-0.7	0.0	0.4	-2.8	-2.5
Hypothyroidism (self reported)	0.3	0.7	2.1	0.3	1.5	1.1	0.5	0.8	0.0
Respiratory disease	0.4	1.0	4.1	-0.4	2.0	1.2	-0.0	0.4	-0.2
Type 2 Diabetes (T2D) (2018)	0.8	1.5	2.3	-1.2	-1.5	-0.9	-1.1	-1.5	-1.1
Lung FEV1/FVC ratio	1.4	7.1	16.2	2.3	-4.0	-2.6	1.7	2.5	2.3
Lung FVC	1.0	4.9	8.3	-1.8	2.3	2.9	0.2	-2.2	-2.8
Neuroticism	0.2	0.5	1.1	-1.0	0.5	0.6	-0.5	-0.7	-0.9
Chronotype (morning person)	1.8	4.1	13.7	-0.1	3.7	2.9	-1.5	-0.5	-0.3
Hair Pigment	0.1	1.8	5.8	-0.1	2.4	1.7	1.1	1.1	-0.0
Tanning	0.2	2.2	6.6	-0.2	2.6	1.8	-1.4	0.8	0.5
Hand grip strength (left)	0.2	0.4	1.8	0.2	-1.3	-0.5	-0.2	-0.7	-0.1
Number of treatments/medications taken	3.9	7.1	12.2	-3.5	2.4	3.1	-0.9	-2.6	-2.7
Average weekly spirits intake	0.7	0.8	1.2	-0.8	0.9	0.6	1.1	-1.1	-1.0
Sensitivity / hurt feelings	3.6	6.1	9.2	-2.4	3.0	2.7	-1.2	-2.3	-2.7
Frequency of depressed mood in last 2 weeks	0.9	1.2	1.8	-0.8	1.2	1.3	1.0	-0.8	-1.2
Hearing difficulty/problems: Yes	2.6	4.0	7.1	-1.9	1.8	2.3	-0.3	-2.2	-2.7
Relative age of first facial hair	3.9	8.0	14.5	-3.8	1.8	2.7	-1.6	-3.1	-3.4
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	5.8	-0.7	-2.4	-1.8	1.5	-0.2	-0.4
Ever used hormone-replacement therapy (HRT)	0.9	1.1	3.4	-1.8	-0.1	0.2	-0.6	-0.9	-1.4
Ever had hysterectomy (womb removed)	0.5	0.5	1.2	-1.0	0.1	0.4	1.1	-0.5	-0.7
Systolic blood pressure, automated reading	2.6	7.5	14.0	-3.7	1.4	2.5	1.0	-3.4	-3.1
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	3.1	-1.6	-1.5	-0.3	-0.1	-1.8	-1.2
Angina	1.2	1.6	3.4	-0.9	1.8	1.4	0.0	-1.0	-1.5
Medication for hormone replacement therapy	0.4	0.5	1.3	-1.1	-0.8	-0.2	-0.2	-0.5	-0.9
Vitamin and mineral supplements	0.8	1.1	1.7	1.3	-1.0	-1.1	1.0	0.9	0.8
Supplements: Zinc	0.5	0.6	1.6	0.5	0.7	0.6	-1.3	0.7	0.5
Medication: Co-codamol	1.1	1.2	2.5	-1.1	1.2	1.6	0.3	-0.8	-1.2
Medication: Metformin	0.9	1.3	2.6	-1.0	-1.0	-0.4	-1.6	-1.4	-1.0
Diabetes (father)	3.2	4.0	6.4	2.0	-1.9	-2.5	1.3	1.7	2.3
Diabetes (mother)	0.6	0.8	1.7	1.0	-1.1	-1.3	0.3	-0.1	0.8
Severe depression (siblings)	2.2	2.5	4.5	-1.3	2.1	1.7	-1.6	-0.9	-1.5
Pack years adult smoking proportion	1.1	1.7	3.0	-1.6	-0.3	0.6	-1.5	-1.7	-1.5
Impedance of leg (right)	0.6	3.1	6.0	-2.5	1.4	1.7	-0.3	-1.8	-2.1
Leg fat-free mass (left)	0.1	0.7	1.8	1.3	-1.1	-0.8	-0.1	0.2	0.4
Trunk fat percentage	0.5	2.0	4.3	-1.6	-0.4	0.0	1.0	-2.0	-2.1
Hand grip strength (right)	0.2	0.6	1.7	-0.2	0.3	0.6	-1.3	-1.0	-0.6
Townsend deprivation index at recruitment	2.7	3.8	5.5	-2.3	1.1	2.2	-1.6	-2.1	-2.0
Current tobacco smoking	3.1	5.1	10.8	-3.3	0.9	1.4	-0.8	-2.9	-2.8
Average weekly fortified wine intake	0.1	0.1	0.2	-0.1	0.4	0.4	0.5	0.1	-0.4
Maternal smoking around birth	5.1	7.4	14.6	-3.6	-0.1	1.1	-1.0	-3.8	-3.8
Fed-up feelings	0.0	0.0	0.1	-0.2	-0.0	-0.0	0.1	-0.2	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	2.7	-1.3	0.5	1.1	-0.6	-1.6	-1.6
Relative age voice broke	2.1	3.2	6.5	-2.1	0.4	1.5	-2.5	-1.6	-1.7
Taking other prescription medications	8.5	13.0	17.7	-4.2	2.9	4.2	-1.6	-3.8	-4.2
Age when periods started (menarche)	0.7	1.6	2.8	1.7	-1.0	-1.3	-0.8	1.5	1.2
Bilateral oophorectomy (both ovaries removed)	5.2	6.0	13.1	-3.6	0.6	1.8	0.4	-3.1	-3.0
Heel bone mineral density (BMD) T-score, automated (left)	5.8	13.2	20.2	3.7	-3.4	-3.7	4.5	3.4	2.9
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.9	0.5	1.2	1.4	-1.3	0.2	0.2
Qualifications: CSEs or equivalent	1.0	1.3	4.5	0.8	2.1	1.6	0.3	0.0	-0.0
Serious illness, injury or assault to yourself	1.5	1.8	3.5	-1.4	1.2	1.9	-0.9	-1.0	-1.4
High blood pressure	3.3	9.1	20.6	-4.5	-0.0	1.1	0.4	-4.1	-3.9
Hayfever, allergic rhinitis or eczema	1.7	3.7	15.7	-0.3	4.0	2.5	-0.1	0.5	-0.3
Multivitamins +/- minerals	0.3	0.4	0.9	-0.4	0.7	0.8	-1.0	-0.4	-0.3
Stomach or abdominal pain in last month	1.1	1.3	3.5	-0.9	1.9	1.6	-1.0	-0.4	-0.3
Supplements: Glucosamine	0.2	0.3	1.4	-0.1	0.0	0.5	-1.2	0.3	0.3
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.2	0.1	-1.5	-1.1	1.1	-0.4	0.2
Medication: Atenolol	2.2	2.7	5.0	-2.2	0.9	1.3	-0.0	-2.0	-2.2
Medication: Levothyroxine sodium	0.5	0.9	2.6	-0.7	1.6	1.1	0.6	-0.0	-0.7
Sitting height	0.2	1.3	5.1	2.3	-0.3	-0.8	-0.3	1.3	0.8
Chronic bronchitis/emphysema (father)	0.5	0.6	1.7	0.6	-0.1	-0.3	-0.4	1.1	1.3
High blood pressure (mother)	0.3	0.4	1.2	-0.5	-0.4	-0.2	0.2	-1.1	-0.7
Body mass index (BMI)	0.1	0.5	2.3	0.6	-0.1	-0.3	1.5	0.2	0.1
Impedance of leg (left)	0.9	4.3	7.4	-2.7	2.1	2.1	0.1	-2.0	-2.3
Leg predicted mass (left)	0.2	0.8	2.1	1.4	-1.2	-0.9	0.0	0.3	0.5
Trunk fat mass	0.2	0.9	1.9	-0.7	-0.5	-0.2	1.0	-1.2	-1.4
Waist circumference	0.3	1.0	4.0	0.6	0.9	0.7	2.0	0.6	-0.1
Number of incorrect matches in round	0.3	0.5	1.8	-1.3	0.9	0.2	0.2	-0.7	-0.4
Past tobacco smoking	1.9	3.5	6.1	2.5	-1.8	-1.6	0.1	1.9	2.3
Alcohol usually taken with meals	7.5	12.2	19.8	3.6	-3.9	-4.4	1.6	3.3	3.4
Nervous feelings	3.6	6.8	10.0	-3.0	1.8	2.4	-2.0	-3.0	-3.2
Frequency of tenseness / restlessness in last 2 weeks	2.3	3.6	6.4	-2.5	1.4	1.8	-0.6	-2.1	-2.2
Hearing difficulty/problems with background noise	2.4	3.8	6.8	-2.6	0.4	1.6	-0.4	-2.6	-2.6
Hair/balding pattern: Pattern 2	1.4	1.7	3.1	1.4	-1.4	-1.3	-0.5	1.1	1.8
Had menopause	1.1	1.4	2.7	0.9	-1.6	-1.6	0.5	1.3	0.7
Had other major operations	0.4	0.5	1.1	-0.7	1.1	0.7	0.8	-0.0	-0.5
Forced vital capacity (FVC)	0.6	2.2	4.0	-0.9	1.2	2.0	-0.6	-1.7	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	8.3	18.9	32.8	4.0	-3.7	-4.8	5.7	3.9	3.5
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	4.5	-1.3	2.1	1.6	-0.4	-0.7	-1.5
Qualifications: None of the above	1.4	2.9	4.5	-2.1	1.7	2.1	-0.5	-1.5	-1.9
Financial difficulties in last 2 years	0.6	0.8	4.0	-0.2	-0.2	-0.8	2.0	-0.1	-0.1
Mouth/teeth dental problems	0.6	1.0	1.5	0.9	-1.1	-1.2	-1.1	0.7	0.7
Heart attack	0.6	0.8	1.6	1.0	-0.6	-1.3	0.7	0.8	0.8
Allergy	1.9	4.3	15.8	0.1	-4.0	-2.8	1.2	-0.8	-0.3
Pain all over the body in last month	1.4	1.5	2.8	-1.7	-0.2	0.2	1.1	-1.7	-1.4
Diabetes (self-reported)	0.5	0.8	1.7	-0.8	-1.3	-0.3	-1.1	-0.9	-0.5
Hayfever/allergic rhinitis (self-reported)	2.0	2.6	5.5	-1.2	2.3	2.2	-1.1	-0.5	-1.6
Medication: Ramipril	0.4	0.5	1.2	-0.8	-0.0	-0.5	0.6	-1.1	-0.9
Medication: Simvastatin	0.3	0.4	0.9	-0.3	0.4	0.7	-0.4	-0.9	-1.0
Fluid intelligence score	2.3	4.8	7.9	2.8	-1.4	-2.0	-0.6	2.7	2.8
Illnesses of siblings	0.4	0.6	1.2	1.1	0.6	-0.0	-0.0	0.9	1.1
Neuroticism score	0.6	1.2	1.7	-1.3	1.2	1.0	0.0	-1.1	-1.3
Weight	0.0	0.2	0.4	0.6	-0.5	-0.4	0.6	-0.2	-0.3
Impedance of arm (right)	1.0	4.8	8.7	-3.0	-0.3	0.5	-1.9	-2.8	-2.8
Arm fat percentage (right)	0.1	0.5	1.0	-0.3	-0.7	-0.5	1.0	-0.8	-0.7
Trunk fat-free mass	0.6	3.7	8.4	2.9	-1.1	-1.3	1.1	2.3	2.1
Hip circumference	0.4	1.7	3.5	-1.6	-1.1	-0.2	-0.1	-1.8	-1.9
Time employed in main current job	1.3	1.5	6.0	0.0	2.4	1.3	0.8	-0.7	-0.2
Alcohol intake versus 10 years previously	0.3	0.5	2.1	-0.7	0.1	0.0	1.5	-0.3	-0.4
Father’s age at death	1.2	1.6	2.5	1.3	-1.5	-1.6	-0.4	1.5	1.0
Worrier / anxious feelings	1.5	2.8	6.3	-1.0	2.4	2.5	-1.0	-1.2	-1.3
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.3	7.3	-2.7	0.6	0.9	-1.3	-2.4	-2.1
Falls in the last year	0.3	0.4	1.1	-0.4	0.8	0.5	-1.0	-0.3	-0.3
Hair/balding pattern: Pattern 3	2.0	3.1	7.9	-1.8	0.1	1.0	-1.9	-2.8	-1.6
Number of live births	0.5	0.7	2.2	0.1	1.5	1.1	0.5	0.4	-0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.6	-0.3	-0.0	1.2	-0.2	-1.1	-1.3
Pulse rate	0.8	1.4	2.8	-1.6	0.7	0.7	0.1	-1.7	-1.4
Happiness	1.2	1.5	4.6	-0.7	0.0	1.3	-2.2	-0.8	-1.0
Noisy workplace	2.5	3.1	5.0	-1.8	1.9	2.2	-0.5	-1.8	-1.7
Qualifications: A levels/AS levels or equivalent	3.2	7.0	10.0	2.9	-3.0	-3.2	0.4	2.2	3.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.3	-0.1	0.7	0.1	1.2	-0.2	-0.2
Mouth/teeth dental problems: Dentures	0.7	1.2	2.0	1.4	0.8	0.5	1.4	1.3	0.9
Asthma	0.9	1.8	6.8	-0.4	2.6	1.9	-0.2	0.5	-0.6
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	1.9	-1.3	0.7	1.0	-1.0	-1.2	-1.4
Medication: Cholesterol lowering	0.3	0.5	1.8	1.4	0.0	0.0	-0.7	0.7	0.6
Depression (self-reported)	1.5	1.8	2.8	-1.6	1.3	1.1	-0.1	-1.6	-1.7
Medication: Lansoprazole	1.2	1.3	3.1	-1.0	0.6	1.1	-1.8	-1.1	-1.0
Prospective memory result	1.6	2.0	4.2	-2.0	0.1	0.9	0.1	-2.1	-1.7
Lung cancer (father)	1.9	2.2	3.9	-1.1	1.6	1.7	-2.0	-1.1	-1.1
Illnesses of mother	0.7	0.9	2.3	0.7	0.4	-0.1	1.5	1.1	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.3	-0.6	0.0	1.5	-0.5	-1.4	-1.4
Pulse wave Arterial Stiffness index	0.5	0.6	2.9	0.0	0.8	-0.1	1.7	0.5	0.0
Impedance of arm (left)	1.6	7.4	12.6	-3.4	-0.4	0.6	-2.8	-3.5	-3.4
Arm fat mass (right)	0.1	0.4	1.4	0.2	-0.6	-0.5	1.2	-0.4	-0.5
Trunk predicted mass	0.7	3.8	8.5	2.9	-1.1	-1.4	1.1	2.3	2.2
Standing height	0.1	0.8	2.0	-0.0	-1.0	-0.4	-1.4	-0.8	-1.0
Length of working week for main job	1.7	1.8	5.4	1.1	-2.3	-1.7	-0.0	0.3	1.3
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.2	0.1	-0.2	-0.2	-0.5	-0.3
Breastfed as a baby	0.6	0.8	2.2	0.8	1.5	0.6	0.8	0.8	0.5
Tense / ‘highly strung’	2.6	4.3	6.4	-2.3	1.5	2.0	-1.3	-2.5	-2.5
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.0	6.6	-1.8	2.6	2.0	0.1	-1.4	-1.4
Hair/balding pattern: Pattern 4	6.0	14.5	31.7	-5.5	-0.4	-0.4	0.3	-5.6	-5.0
Birth weight of first child	0.4	0.7	1.4	0.8	1.2	0.6	0.2	0.7	1.1
Peak expiratory flow (PEF)	0.1	0.3	1.0	1.0	-0.8	0.0	0.4	0.3	-0.1
Pulse wave reflection index	1.9	2.4	4.4	1.8	0.2	-0.8	2.1	1.7	1.8
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	-0.4	0.0	0.4	0.3	-0.6	-0.4
Loud music exposure frequency	5.0	5.5	8.3	-2.9	2.0	2.2	-1.0	-2.6	-2.8
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.3	-0.1	-1.2	-0.2	-1.5	-0.9	0.0
Mouth/teeth dental problems: Bleeding gums	3.1	4.0	8.5	-2.9	0.7	1.6	-0.5	-2.5	-2.5
Blood clot in the leg (DVT)	1.3	1.7	4.8	1.0	0.3	0.7	-2.2	1.2	1.5
Medication: Paracetamol	1.6	2.6	6.1	-1.4	2.5	1.9	0.7	-1.0	-1.6
Headache pain in last month	1.7	2.9	5.3	-1.5	2.3	2.1	0.5	-1.3	-1.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.2	-0.3	0.3	-0.2	1.1	0.3	0.3
Glaucoma (self-reported)	0.5	0.6	1.4	-0.5	1.0	1.2	0.9	0.0	-0.1
Gout (self-reported)	0.3	0.5	1.1	-0.1	-1.0	-0.6	-1.0	-0.6	-0.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.8	-0.9	1.4	1.2	0.5	-0.2	-0.9
Medication: Amlodipine	1.2	1.7	3.6	-1.9	0.2	1.0	-0.6	-1.9	-1.2
Medication: Ventolin 100micrograms inhaler	1.2	1.5	6.2	0.2	2.5	1.0	1.0	0.8	-0.1
Birth weight	1.2	2.6	6.9	2.1	-0.4	-0.4	1.0	2.6	1.7
Chronic bronchitis/emphysema (mother)	1.9	2.2	3.3	-1.4	1.2	1.6	-1.4	-1.4	-1.8
High blood pressure (siblings)	2.0	2.8	4.9	-2.2	1.0	1.4	0.1	-2.1	-2.2
Forced vital capacity (FVC), Best measure	0.7	2.7	5.0	-1.1	1.3	2.2	-1.1	-1.8	-2.0
Body fat percentage	0.4	1.6	3.3	-1.3	-0.3	0.2	1.1	-1.7	-1.8
Leg fat percentage (right)	0.2	0.7	2.8	-0.5	-0.1	0.2	1.7	-0.6	-0.9
Arm fat-free mass (right)	0.3	1.6	4.4	2.1	-0.3	-0.6	1.0	1.4	1.3
Exposure to tobacco smoke outside home	0.7	1.0	2.0	-1.1	0.2	0.4	1.4	-1.0	-1.2
Comparative body size at age 10	0.1	0.2	0.5	0.6	0.2	0.4	0.7	-0.4	0.3
Number of full brothers	0.6	0.8	2.3	0.9	-1.5	-0.7	0.4	0.7	0.7
Worry too long after embarrassment	2.8	4.7	5.3	-2.0	2.0	2.3	-2.3	-2.1	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.2	2.1	1.0	-0.8	-1.4	1.3	1.0	1.0
Wheeze or whistling in the chest in last year	2.8	4.9	12.7	-1.2	3.6	3.1	-1.3	-0.7	-1.9
Number of children fathered	0.3	0.3	0.5	-0.2	-0.7	0.0	0.7	-0.7	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.1	-0.7	1.2	0.9	-1.5	-0.4	-0.3
Age at first live birth	5.0	8.8	12.8	3.3	-3.4	-3.6	0.7	2.6	3.3
Pulse wave peak to peak time	0.5	0.6	2.7	0.2	-0.9	-0.0	-1.6	-0.4	0.0
Health satisfaction	2.7	3.5	6.3	-2.5	0.8	1.6	-0.4	-2.3	-2.5
Shortness of breath walking on level ground	0.7	0.8	1.9	-0.9	0.6	0.5	1.4	-0.8	-1.0
Qualifications: College or University degree	2.4	7.6	9.2	3.0	-2.9	-3.0	2.0	2.8	2.7
Eye problems/disorders: None of the above	1.2	1.4	3.0	1.6	1.1	0.4	-0.0	1.7	1.3
Mouth/teeth dental problems: Loose teeth	1.3	1.6	5.0	-0.6	-1.5	-1.4	2.2	0.1	-0.0
Emphysema/chronic bronchitis	1.2	1.4	3.8	0.9	1.9	1.5	-0.6	0.9	0.7
Medication for pain relief, constipation, heartburn	1.4	2.3	4.0	1.6	-2.0	-1.8	-0.7	1.1	1.5
Neck or shoulder pain in last month	0.4	0.6	1.8	-0.2	1.0	0.6	1.3	-0.1	-0.5
Medication: Blood pressure	0.2	0.3	0.7	-0.2	-0.2	0.1	-0.6	-0.8	-0.7
Angina (self-reported)	0.9	1.2	3.2	-0.6	1.8	1.2	0.1	-0.7	-1.2
Migraine (self-reported)	2.5	3.0	6.6	-1.7	2.1	2.6	-1.0	-1.2	-1.3
Medication: Ibuprofen	1.4	1.7	1.9	-1.4	1.2	1.4	-1.4	-1.3	-1.1
Medication: Allopurinol	0.6	0.8	1.8	-0.7	-0.9	-0.2	-1.4	-0.9	-0.9
Medication: Omeprazole	1.3	1.6	2.1	-1.5	0.9	1.4	-1.4	-1.0	-1.2
Medication: Seretide 50 evohaler	0.3	0.4	0.6	0.4	-0.7	-0.8	0.1	0.8	0.5
Mean time to correctly identify matches	0.3	0.7	2.0	0.7	0.8	0.0	-0.2	0.9	1.4
Heart disease (mother)	0.4	0.4	0.8	-0.9	-0.4	-0.1	-0.7	-0.6	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.5	-1.1	0.9	0.7	0.8	-1.2	-1.1
Whole body fat mass	0.2	0.7	1.6	-0.5	-0.4	0.0	1.0	-1.1	-1.3
Leg fat mass (right)	0.1	0.5	1.7	-0.1	-0.1	0.2	1.3	-0.6	-0.8
Arm predicted mass (right)	0.3	1.7	4.5	2.1	-0.5	-0.8	1.1	1.4	1.3
Pulse rate, automated reading	0.1	0.2	0.5	0.4	-0.7	-0.2	0.1	0.2	0.7
Alcohol intake frequency.	0.3	0.8	4.4	0.1	-0.1	-0.3	2.1	0.4	0.1
Comparative height size at age 10	0.3	1.8	4.6	-0.9	0.4	1.1	-2.1	-1.3	-1.5
Number of full sisters	4.1	4.9	9.5	-1.3	1.6	2.5	-3.1	-2.1	-2.3
Suffer from ‘nerves’	0.6	0.9	1.7	-1.3	0.9	0.3	-0.5	-0.9	-1.3
Overall health rating	1.4	3.0	6.6	-2.6	0.1	1.0	0.2	-2.0	-2.5
Chest pain or discomfort	0.2	0.3	0.9	0.3	0.5	0.3	-0.5	0.9	0.4
Had major operations	1.3	1.6	2.6	1.4	-1.6	-1.0	0.4	1.2	1.5
Age at last live birth	5.2	7.5	10.8	3.3	-3.1	-3.1	0.0	2.6	2.9
Family relationship satisfaction	1.2	1.5	2.9	-1.2	1.3	1.7	-0.6	-1.3	-1.0
Leg pain on walking	0.8	1.0	4.7	-0.4	-0.2	-0.9	2.2	0.2	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.2	1.1	-0.1	-0.0	-0.9	0.7	0.7
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.5	0.6	0.3	0.7	0.7	0.2	0.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.0	0.8	0.1	0.1	-1.4	0.4	0.5
Medication: Aspirin	0.4	0.6	2.1	0.5	-0.1	-0.7	1.5	0.2	0.7
Supplements: Vitamin C	0.2	0.3	0.9	-1.0	-0.0	-0.2	-0.4	-0.6	-0.5
Knee pain experienced in last month	0.2	0.2	0.8	-0.6	-0.2	0.1	0.3	-0.4	-0.9
Hypertension (Self-reported)	3.3	9.3	20.7	-4.5	0.1	1.2	0.4	-4.2	-3.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	4.4	-0.2	0.6	1.5	-2.1	-0.3	-0.6
Illnesses of father: Heart disease	1.9	2.6	4.6	1.3	-2.0	-2.2	1.3	1.4	1.2
Illnesses of siblings: Diabetes	0.6	0.7	1.8	1.3	-0.4	-0.4	-0.9	1.0	0.6
Smoking status: Previous	0.2	0.3	0.6	-0.7	0.7	0.1	0.4	-0.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.7	0.7	1.3	1.3	-1.7	-0.1	-0.0
Whole body fat-free mass	0.4	2.2	5.5	2.4	-1.1	-1.2	0.8	1.5	1.5
Leg fat-free mass (right)	0.2	0.8	2.3	1.5	-1.1	-0.9	0.0	0.4	0.6
Arm fat percentage (left)	0.1	0.4	0.8	-0.4	-0.7	-0.4	0.7	-0.9	-0.8
Average weekly red wine intake	1.2	1.7	4.1	2.0	-0.3	-0.9	0.0	1.5	1.8
Handedness (chirality/laterality): Left-handed	0.9	1.1	5.5	0.4	-0.5	-0.7	2.3	0.2	0.5
Mood swings	0.1	0.2	0.9	0.4	1.0	0.5	-0.0	0.1	0.1
Loneliness, isolation	0.4	0.5	1.4	-0.8	0.6	0.4	1.2	-0.5	-0.7
Long-standing illness, disability or infirmity	1.1	1.6	2.8	-1.7	1.1	1.2	0.9	-0.9	-1.7
Ever had bowel cancer screening	0.9	1.0	2.5	0.8	-1.6	-1.4	0.3	0.7	0.7
Diabetes diagnosed by doctor	0.4	0.6	2.3	-0.2	-1.5	-1.1	-0.1	-0.3	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	0.3	0.6	0.3	0.0	0.2	0.4
Friendships satisfaction	0.2	0.3	0.7	-0.9	0.2	0.6	0.3	-0.5	-0.5
Qualifications: nursing, teaching	0.7	1.2	2.5	0.8	-0.9	-1.6	1.1	1.1	0.9
Commuting to job workplace: Walk	0.4	0.4	1.0	-0.5	-0.1	-1.0	0.9	0.5	0.5
Eye problems/disorders: Cataract	0.8	1.0	1.3	-1.1	-1.1	-0.7	0.8	-1.1	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.8	-1.4	0.3	-0.3	0.4	-0.9	-0.8
Medication for cholesterol	2.3	3.5	8.8	3.0	-0.5	-1.4	-0.5	2.1	2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	3.0	0.5	-0.5	-1.2	1.7	0.7	0.8
Back pain experienced in last month	0.4	0.5	1.9	-0.8	0.0	0.7	-1.4	-0.3	-0.5
Mineral and other dietary supplements	0.2	0.3	0.8	0.1	-0.9	-0.8	-0.1	-0.5	-0.6
Breast cancer (self-reported)	1.4	1.7	3.1	-0.9	1.5	1.7	0.2	-1.1	-1.8
Asthma (self-reported)	0.9	1.7	5.8	-0.8	2.4	1.8	-0.1	0.1	-0.8
Osteoporosis (self-reported)	0.2	0.2	0.5	-0.4	0.3	0.7	-0.6	0.2	0.1
Osteoarthritis (self-reported)	0.2	0.3	0.9	-0.7	-0.4	-0.1	0.5	-0.2	-0.9
Medication: Aspirin	0.4	0.5	1.5	0.4	-0.3	-0.8	1.2	0.1	0.5
Medication: Gliclazide	0.8	0.9	1.3	0.6	-1.1	-1.1	-0.7	0.7	1.1
Illnesses of father: None of the above (group 1)	2.4	2.9	7.8	-0.7	2.8	2.5	-1.1	-1.0	-1.1
Smoking status: Current	3.1	4.9	9.8	-3.1	0.8	1.5	-0.9	-2.9	-2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	4.1	-1.1	0.9	1.8	-0.4	-1.5	-2.0
Whole body water mass	0.4	2.2	5.5	2.3	-1.1	-1.2	0.9	1.5	1.5
Leg predicted mass (right)	0.2	0.8	2.2	1.5	-1.1	-0.9	0.1	0.4	0.6
Arm fat mass (left)	0.1	0.4	1.2	0.2	-0.7	-0.5	1.1	-0.4	-0.5
Number of self-reported non-cancer illnesses	3.5	6.0	10.5	-3.2	2.3	2.6	-0.5	-2.4	-2.7
Average weekly champagne plus white wine intake	0.4	0.6	3.5	0.2	0.1	0.2	-1.9	-0.2	-0.2
Miserableness	1.3	2.3	4.3	-1.9	0.6	0.7	1.3	-1.9	-2.1
Guilty feelings	1.9	2.8	8.7	-1.3	2.9	1.7	0.6	-0.9	-1.6
Wears glasses or contact lenses	0.1	0.1	0.6	-0.1	0.0	0.3	-0.8	0.3	0.1
Ever taken oral contraceptive pill	0.5	0.5	1.2	1.1	0.1	0.1	-0.2	0.8	1.1
Hearing aid user	1.3	1.5	2.4	1.1	-1.2	-1.6	1.4	1.1	0.9
Mother’s age at death	0.5	0.7	1.3	1.0	0.1	-0.7	0.1	1.1	1.0
Financial situation satisfaction	0.4	0.4	1.0	-0.4	-0.4	0.6	-0.6	-1.0	-0.8
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.3	-0.5	-0.5	0.3	0.1	-0.4	-0.6
Commuting to job workplace: Public transport	1.1	1.3	2.2	1.1	-1.5	-1.5	0.2	0.9	1.1
Eye problems/disorders: Glaucoma	1.0	1.2	4.3	0.1	1.2	1.0	2.1	0.4	0.3
Medication: Blood pressure	5.5	10.5	26.1	-5.1	0.7	1.9	0.5	-4.2	-3.8
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.7	-0.5	-0.3	-0.6	1.3	0.0	-0.6
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.9	-1.0	0.6	0.3	0.5	-0.6	-0.4
High cholesterol (Self-reported)	0.1	0.1	0.2	0.3	0.4	0.2	0.1	0.5	-0.0
Medication: Bendroflumethiazide	2.6	3.9	9.5	-2.9	-0.0	0.9	0.5	-3.1	-2.1
Medication: Paracetamol	2.4	3.7	5.3	-2.3	2.1	1.9	-0.5	-1.9	-2.2
Medication: Lisinopril	0.2	0.3	1.4	0.1	-1.2	-0.5	0.2	-0.4	0.1
Medication: Atorvastatin	0.8	0.9	3.1	0.4	1.8	0.8	0.7	1.1	0.4
Illnesses of father: High blood pressure	0.9	1.1	2.2	-1.5	-1.0	-0.5	0.6	-1.3	-1.1
Alcohol drinker status: Never	1.2	1.4	2.7	1.4	0.0	-0.6	0.9	1.6	1.6
Ever smoked	2.4	4.2	8.0	-2.8	1.7	1.7	-0.7	-2.2	-2.4
Basal metabolic rate	0.2	1.4	3.6	1.9	-0.9	-0.9	0.8	1.1	1.0
Leg fat percentage (left)	0.3	1.1	3.4	-0.8	0.5	0.5	1.8	-0.8	-1.1
Arm fat-free mass (left)	0.4	2.0	4.9	2.2	-0.1	-0.5	1.4	1.7	1.4
Number of operations (self-reported)	0.6	0.9	4.0	0.4	-0.7	-0.6	2.0	0.5	0.6
Average weekly beer plus cider intake	1.5	2.1	3.6	-1.2	1.3	1.8	-1.9	-1.3	-1.1
Irritability	2.3	3.9	6.7	1.6	-1.4	-2.3	2.6	1.6	2.1
Risk taking	0.3	0.4	0.9	0.5	-0.3	-0.7	0.7	0.9	0.6
Ever had prostate specific antigen (PSA) test	2.0	2.3	4.9	2.2	-0.0	-1.1	0.7	2.1	1.6
Fractured/broken bones in last 5 years	4.6	5.9	12.5	-1.4	3.4	3.5	-2.2	-1.4	-1.6
Age started oral contraceptive pill	0.3	0.3	1.6	-0.0	0.0	0.5	-1.3	0.1	-0.3
Diastolic blood pressure, automated reading	1.0	3.0	5.5	-1.7	1.7	2.4	-0.8	-1.8	-1.7
Ever depressed for a whole week	3.1	3.8	9.8	-1.2	3.1	2.6	-0.9	-1.1	-1.7
Unable to work because of sickness or disability	0.4	0.6	0.9	-1.0	0.7	0.9	0.3	-0.7	-0.7
Commuting to job workplace: Cycle	0.9	1.1	2.9	1.0	0.8	-0.7	-0.2	1.3	1.7
Myopia	0.4	0.6	1.3	-0.7	0.6	0.8	-0.5	-0.7	-1.2
Vascular/heart problems diagnosed by doctor	2.4	6.4	14.6	3.8	0.1	-0.6	-0.7	3.6	3.2
Cholesterol lowering medication	0.9	1.4	2.1	-1.3	1.4	1.0	0.8	-0.9	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.8	-1.0	0.5	0.8	-1.3	-0.8	-0.7
Pain experienced in last month	2.1	3.5	7.7	2.6	0.0	-1.1	0.4	2.2	2.8
Supplements: Calcium	0.8	0.9	2.3	-0.6	0.8	1.5	-1.2	-0.5	-0.4
Basal cell carcinoma (self-reported)	2.0	2.4	3.8	-1.6	1.2	1.5	-1.3	-2.0	-1.7
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.0	0.7	-0.3	-1.0	0.6	0.5	0.5
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	5.6	1.3	0.6	0.7	-2.4	1.5	1.7
Heart disease (siblings)	0.4	0.5	1.5	-0.5	-0.8	0.0	-1.2	-0.2	-0.8
Alcohol drinker status: Previous	0.5	0.5	1.0	-1.0	-0.6	-0.2	-0.4	-0.9	-1.0
Pack years of smoking	1.3	1.9	3.3	-1.8	-0.3	0.5	-1.4	-1.8	-1.6
Impedance of whole body	1.2	6.0	11.1	-3.3	0.9	1.5	-1.5	-3.1	-3.2
Leg fat mass (left)	0.2	0.6	1.4	-0.4	0.4	0.6	1.2	-0.9	-1.0
Arm predicted mass (left)	0.4	2.1	5.2	2.3	-0.4	-0.7	1.5	1.6	1.4