Hub : Genes

XBP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Pancreas 0.1490 0.0510 5.5e-05 0.132 NA 0.015 NA 0.143 3.5e-06 NA 7.5e-02 NA 1.3e-06
2 NTR Blood 0.0280 0.0084 2.9e-08 0.029 0.024 0.021 0.026 0.021 8.4e-10 2.7e-08 2.0e-07 8.2e-09 1.5e-07
3 YFS Blood 0.1307 0.0257 0.0e+00 0.142 0.197 0.204 0.203 0.201 3.0e-44 2.2e-62 1.1e-64 1.8e-64 1.4e-63
4 TCGA Brain Lower Grade Glioma 0.0417 0.0263 3.2e-03 0.030 0.017 0.022 NA 0.022 2.4e-04 4.0e-03 1.3e-03 NA 1.4e-03
5 TCGA Pancreatic Adenocarcinoma 0.0570 0.0330 5.9e-03 0.034 0.060 0.051 NA 0.038 1.4e-02 1.6e-03 3.5e-03 NA 9.9e-03
6 TCGA Prostate Adenocarcinoma 0.0273 0.0183 3.3e-03 0.017 0.025 0.017 NA 0.023 6.1e-03 1.1e-03 6.1e-03 NA 1.7e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.5 0.9 3.5 -0.8 -0.7 -0.4 1.9 -0.6 -0.4
Bipolar Disorder or Schizophrenia 1.4 3.4 7.8 -2.8 0.6 0.7 1.7 -2.1 -2.2
Depressed Affect (Nagel 2018) 0.1 0.1 0.5 -0.2 0.0 0.0 0.7 -0.1 -0.4
Depression (Nagel 2018) 0.6 0.9 1.6 -1.1 0.8 1.0 0.6 -0.9 -1.3
Intelligence (Savage-Jansen 2018) 1.2 3.6 7.6 1.6 -2.8 -2.6 -0.6 1.6 1.3
Neuroticism (Nagel 2018) 0.6 1.3 2.6 -1.1 1.6 1.2 -0.7 -0.9 -1.2
Schizophrenia (2018) 1.9 3.9 8.6 -2.9 1.3 1.2 0.7 -2.2 -2.5
Schizophrenia vs Biploar Disorder 0.2 0.3 0.9 -0.7 -0.0 0.2 0.4 -0.6 -0.9
Worry (Nagel 2018) 0.8 1.7 2.3 -1.3 1.5 1.3 -1.3 -1.0 -1.4
Alzheimer’s Disease (in mother) 1.2 1.4 2.4 -0.8 1.5 1.5 -1.3 -0.8 -0.9
Alzheimer’s Disease (in father) 0.4 0.5 1.1 -0.6 -0.4 0.4 1.1 -0.7 -0.6
Alzheimer’s Disease (including proxy) 0.6 0.9 2.4 -0.6 0.9 1.5 -1.2 -0.3 -0.4
Crohns Disease (2017) 1.2 2.7 7.1 2.5 0.2 -0.2 -0.3 2.7 1.6
Irritable Bowel Disease (IBD) 0.9 2.2 5.1 2.3 -0.0 -0.3 0.3 2.0 1.9
Ulcerative Colitis (UC) 0.3 0.6 1.4 1.1 -0.6 -0.4 0.3 0.6 1.2
Major Depression (MDD) 1.4 1.7 4.1 0.0 1.8 2.0 -1.6 0.1 -0.7
Reaction Time 0.6 1.1 2.7 1.0 1.1 0.6 -0.7 1.0 1.7
Verbal and Numeric Reasoning (VNR) 1.1 2.6 3.9 2.0 -1.7 -1.9 -0.3 1.6 1.5
Breast Cancer 7.1 17.0 42.1 2.4 -6.5 -5.6 -1.2 3.2 3.3
Ovarian Cancer 2.7 3.5 16.1 -0.2 4.0 2.1 0.4 0.2 -0.6
Prostate Cancer 1.0 1.4 4.3 1.3 2.1 1.3 0.3 0.4 0.6
Age at First Birth 1.2 1.7 5.7 0.6 -2.4 -1.7 0.5 0.2 0.9
Bipolar Disorder (2011) 0.2 0.1 0.4 -0.1 -0.6 -0.6 0.4 -0.2 -0.0
Body Mass Index (BMI) (2010) 1.2 1.7 5.2 1.4 -0.2 -0.3 2.3 1.2 1.2
Coronary Artery Disease (CAD) 1.6 2.0 4.9 0.5 -2.2 -1.8 1.8 0.4 0.6
Crohns Disease (2012) 1.8 3.0 7.4 2.3 -0.3 -0.9 0.0 2.7 2.1
Mean Putamen Volume 0.8 0.9 1.9 -0.5 1.2 1.4 -1.0 -0.1 -0.8
Fasting Glucose 0.7 0.8 1.9 -0.8 -0.2 -0.1 -0.6 -1.4 -1.3
HbA1C 0.2 0.2 0.5 0.6 0.4 0.2 -0.7 -0.3 0.0
HDL Cholesterol 1.7 2.9 4.2 -2.1 1.6 1.4 -1.0 -1.9 -2.0
LDL Cholesterol 0.1 0.2 0.8 0.3 0.1 0.2 -0.9 0.3 0.3
Lupus 0.8 1.3 4.8 0.1 -1.4 -0.7 2.2 -0.0 0.8
Neuroticism (2016) 4.0 5.8 8.2 -2.6 2.6 2.6 -0.9 -2.3 -2.9
Primary Biliary Cirrhosis 0.6 0.9 1.5 -1.1 -0.7 0.7 -0.9 -1.2 -1.0
Rheumatoid Arthritis 1.6 2.3 5.7 1.0 -2.4 -1.7 -0.3 1.2 1.6
Schizophrenia (2014) 3.4 7.5 16.5 -4.1 1.3 1.9 0.7 -3.3 -3.5
Triglycerides 0.7 1.2 2.5 1.6 -0.3 -0.5 1.3 1.1 1.2
Type 2 Diabetes (T2D) (2012) 1.4 1.6 4.0 -1.1 2.0 1.5 -0.5 -1.1 -0.9
Ulcerative Colitis 0.4 0.6 1.9 0.9 0.5 0.6 -0.3 0.6 1.4
Blood Eosinophil Count 0.4 3.2 6.7 -1.4 2.6 2.1 -1.2 -0.8 -2.0
Blood Platelet Count 0.5 6.0 14.1 -1.1 3.8 3.6 -1.5 -0.3 -2.2
Blood Red Count 1.3 12.8 26.6 4.9 0.8 -0.7 2.9 5.2 4.1
Blood White Count 0.3 2.1 6.5 -0.4 -2.5 -2.0 1.3 -0.0 -0.1
Heel T-Score 9.3 74.2 112.4 7.3 -8.5 -9.8 10.6 8.2 6.6
BMI 0.2 1.3 5.4 1.0 0.1 -0.7 2.3 0.6 0.6
Height 0.1 2.6 6.4 -0.8 -1.4 0.0 -2.5 -1.6 -2.0
Waist Hip Ratio (WHR) 2.0 8.8 17.0 2.1 4.1 2.4 3.8 2.9 1.7
Systolic Blood Pressure 2.0 10.0 20.1 -4.5 0.7 1.6 1.1 -4.5 -3.9
Smoking Status 1.9 4.6 10.2 -3.2 1.0 1.1 0.1 -2.9 -2.7
Allergy or Eczema 2.0 5.3 18.2 -1.2 4.3 3.3 0.1 -0.2 -1.1
Cardiovascular Disease 1.2 3.9 8.8 -3.0 -0.7 0.0 0.4 -2.8 -2.5
Hypothyroidism (self reported) 0.3 0.7 2.1 0.3 1.5 1.1 0.5 0.8 0.0
Respiratory disease 0.4 1.0 4.1 -0.4 2.0 1.2 -0.0 0.4 -0.2
Type 2 Diabetes (T2D) (2018) 0.8 1.5 2.3 -1.2 -1.5 -0.9 -1.1 -1.5 -1.1
Lung FEV1/FVC ratio 1.4 7.1 16.2 2.3 -4.0 -2.6 1.7 2.5 2.3
Lung FVC 1.0 4.9 8.3 -1.8 2.3 2.9 0.2 -2.2 -2.8
Neuroticism 0.2 0.5 1.1 -1.0 0.5 0.6 -0.5 -0.7 -0.9
Chronotype (morning person) 1.8 4.1 13.7 -0.1 3.7 2.9 -1.5 -0.5 -0.3
Hair Pigment 0.1 1.8 5.8 -0.1 2.4 1.7 1.1 1.1 -0.0
Tanning 0.2 2.2 6.6 -0.2 2.6 1.8 -1.4 0.8 0.5
Hand grip strength (left) 0.2 0.4 1.8 0.2 -1.3 -0.5 -0.2 -0.7 -0.1
Number of treatments/medications taken 3.9 7.1 12.2 -3.5 2.4 3.1 -0.9 -2.6 -2.7
Average weekly spirits intake 0.7 0.8 1.2 -0.8 0.9 0.6 1.1 -1.1 -1.0
Sensitivity / hurt feelings 3.6 6.1 9.2 -2.4 3.0 2.7 -1.2 -2.3 -2.7
Frequency of depressed mood in last 2 weeks 0.9 1.2 1.8 -0.8 1.2 1.3 1.0 -0.8 -1.2
Hearing difficulty/problems: Yes 2.6 4.0 7.1 -1.9 1.8 2.3 -0.3 -2.2 -2.7
Relative age of first facial hair 3.9 8.0 14.5 -3.8 1.8 2.7 -1.6 -3.1 -3.4
Other serious medical condition/disability diagnosed by doctor 1.5 2.0 5.8 -0.7 -2.4 -1.8 1.5 -0.2 -0.4
Ever used hormone-replacement therapy (HRT) 0.9 1.1 3.4 -1.8 -0.1 0.2 -0.6 -0.9 -1.4
Ever had hysterectomy (womb removed) 0.5 0.5 1.2 -1.0 0.1 0.4 1.1 -0.5 -0.7
Systolic blood pressure, automated reading 2.6 7.5 14.0 -3.7 1.4 2.5 1.0 -3.4 -3.1
Eye problems/disorders: Diabetes related eye disease 1.4 1.6 3.1 -1.6 -1.5 -0.3 -0.1 -1.8 -1.2
Angina 1.2 1.6 3.4 -0.9 1.8 1.4 0.0 -1.0 -1.5
Medication for hormone replacement therapy 0.4 0.5 1.3 -1.1 -0.8 -0.2 -0.2 -0.5 -0.9
Vitamin and mineral supplements 0.8 1.1 1.7 1.3 -1.0 -1.1 1.0 0.9 0.8
Supplements: Zinc 0.5 0.6 1.6 0.5 0.7 0.6 -1.3 0.7 0.5
Medication: Co-codamol 1.1 1.2 2.5 -1.1 1.2 1.6 0.3 -0.8 -1.2
Medication: Metformin 0.9 1.3 2.6 -1.0 -1.0 -0.4 -1.6 -1.4 -1.0
Diabetes (father) 3.2 4.0 6.4 2.0 -1.9 -2.5 1.3 1.7 2.3
Diabetes (mother) 0.6 0.8 1.7 1.0 -1.1 -1.3 0.3 -0.1 0.8
Severe depression (siblings) 2.2 2.5 4.5 -1.3 2.1 1.7 -1.6 -0.9 -1.5
Pack years adult smoking proportion 1.1 1.7 3.0 -1.6 -0.3 0.6 -1.5 -1.7 -1.5
Impedance of leg (right) 0.6 3.1 6.0 -2.5 1.4 1.7 -0.3 -1.8 -2.1
Leg fat-free mass (left) 0.1 0.7 1.8 1.3 -1.1 -0.8 -0.1 0.2 0.4
Trunk fat percentage 0.5 2.0 4.3 -1.6 -0.4 0.0 1.0 -2.0 -2.1
Hand grip strength (right) 0.2 0.6 1.7 -0.2 0.3 0.6 -1.3 -1.0 -0.6
Townsend deprivation index at recruitment 2.7 3.8 5.5 -2.3 1.1 2.2 -1.6 -2.1 -2.0
Current tobacco smoking 3.1 5.1 10.8 -3.3 0.9 1.4 -0.8 -2.9 -2.8
Average weekly fortified wine intake 0.1 0.1 0.2 -0.1 0.4 0.4 0.5 0.1 -0.4
Maternal smoking around birth 5.1 7.4 14.6 -3.6 -0.1 1.1 -1.0 -3.8 -3.8
Fed-up feelings 0.0 0.0 0.1 -0.2 -0.0 -0.0 0.1 -0.2 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 2.7 -1.3 0.5 1.1 -0.6 -1.6 -1.6
Relative age voice broke 2.1 3.2 6.5 -2.1 0.4 1.5 -2.5 -1.6 -1.7
Taking other prescription medications 8.5 13.0 17.7 -4.2 2.9 4.2 -1.6 -3.8 -4.2
Age when periods started (menarche) 0.7 1.6 2.8 1.7 -1.0 -1.3 -0.8 1.5 1.2
Bilateral oophorectomy (both ovaries removed) 5.2 6.0 13.1 -3.6 0.6 1.8 0.4 -3.1 -3.0
Heel bone mineral density (BMD) T-score, automated (left) 5.8 13.2 20.2 3.7 -3.4 -3.7 4.5 3.4 2.9
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 1.9 0.5 1.2 1.4 -1.3 0.2 0.2
Qualifications: CSEs or equivalent 1.0 1.3 4.5 0.8 2.1 1.6 0.3 0.0 -0.0
Serious illness, injury or assault to yourself 1.5 1.8 3.5 -1.4 1.2 1.9 -0.9 -1.0 -1.4
High blood pressure 3.3 9.1 20.6 -4.5 -0.0 1.1 0.4 -4.1 -3.9
Hayfever, allergic rhinitis or eczema 1.7 3.7 15.7 -0.3 4.0 2.5 -0.1 0.5 -0.3
Multivitamins +/- minerals 0.3 0.4 0.9 -0.4 0.7 0.8 -1.0 -0.4 -0.3
Stomach or abdominal pain in last month 1.1 1.3 3.5 -0.9 1.9 1.6 -1.0 -0.4 -0.3
Supplements: Glucosamine 0.2 0.3 1.4 -0.1 0.0 0.5 -1.2 0.3 0.3
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 2.2 0.1 -1.5 -1.1 1.1 -0.4 0.2
Medication: Atenolol 2.2 2.7 5.0 -2.2 0.9 1.3 -0.0 -2.0 -2.2
Medication: Levothyroxine sodium 0.5 0.9 2.6 -0.7 1.6 1.1 0.6 -0.0 -0.7
Sitting height 0.2 1.3 5.1 2.3 -0.3 -0.8 -0.3 1.3 0.8
Chronic bronchitis/emphysema (father) 0.5 0.6 1.7 0.6 -0.1 -0.3 -0.4 1.1 1.3
High blood pressure (mother) 0.3 0.4 1.2 -0.5 -0.4 -0.2 0.2 -1.1 -0.7
Body mass index (BMI) 0.1 0.5 2.3 0.6 -0.1 -0.3 1.5 0.2 0.1
Impedance of leg (left) 0.9 4.3 7.4 -2.7 2.1 2.1 0.1 -2.0 -2.3
Leg predicted mass (left) 0.2 0.8 2.1 1.4 -1.2 -0.9 0.0 0.3 0.5
Trunk fat mass 0.2 0.9 1.9 -0.7 -0.5 -0.2 1.0 -1.2 -1.4
Waist circumference 0.3 1.0 4.0 0.6 0.9 0.7 2.0 0.6 -0.1
Number of incorrect matches in round 0.3 0.5 1.8 -1.3 0.9 0.2 0.2 -0.7 -0.4
Past tobacco smoking 1.9 3.5 6.1 2.5 -1.8 -1.6 0.1 1.9 2.3
Alcohol usually taken with meals 7.5 12.2 19.8 3.6 -3.9 -4.4 1.6 3.3 3.4
Nervous feelings 3.6 6.8 10.0 -3.0 1.8 2.4 -2.0 -3.0 -3.2
Frequency of tenseness / restlessness in last 2 weeks 2.3 3.6 6.4 -2.5 1.4 1.8 -0.6 -2.1 -2.2
Hearing difficulty/problems with background noise 2.4 3.8 6.8 -2.6 0.4 1.6 -0.4 -2.6 -2.6
Hair/balding pattern: Pattern 2 1.4 1.7 3.1 1.4 -1.4 -1.3 -0.5 1.1 1.8
Had menopause 1.1 1.4 2.7 0.9 -1.6 -1.6 0.5 1.3 0.7
Had other major operations 0.4 0.5 1.1 -0.7 1.1 0.7 0.8 -0.0 -0.5
Forced vital capacity (FVC) 0.6 2.2 4.0 -0.9 1.2 2.0 -0.6 -1.7 -1.9
Heel bone mineral density (BMD) T-score, automated (right) 8.3 18.9 32.8 4.0 -3.7 -4.8 5.7 3.9 3.5
Ever unenthusiastic/disinterested for a whole week 1.6 1.9 4.5 -1.3 2.1 1.6 -0.4 -0.7 -1.5
Qualifications: None of the above 1.4 2.9 4.5 -2.1 1.7 2.1 -0.5 -1.5 -1.9
Financial difficulties in last 2 years 0.6 0.8 4.0 -0.2 -0.2 -0.8 2.0 -0.1 -0.1
Mouth/teeth dental problems 0.6 1.0 1.5 0.9 -1.1 -1.2 -1.1 0.7 0.7
Heart attack 0.6 0.8 1.6 1.0 -0.6 -1.3 0.7 0.8 0.8
Allergy 1.9 4.3 15.8 0.1 -4.0 -2.8 1.2 -0.8 -0.3
Pain all over the body in last month 1.4 1.5 2.8 -1.7 -0.2 0.2 1.1 -1.7 -1.4
Diabetes (self-reported) 0.5 0.8 1.7 -0.8 -1.3 -0.3 -1.1 -0.9 -0.5
Hayfever/allergic rhinitis (self-reported) 2.0 2.6 5.5 -1.2 2.3 2.2 -1.1 -0.5 -1.6
Medication: Ramipril 0.4 0.5 1.2 -0.8 -0.0 -0.5 0.6 -1.1 -0.9
Medication: Simvastatin 0.3 0.4 0.9 -0.3 0.4 0.7 -0.4 -0.9 -1.0
Fluid intelligence score 2.3 4.8 7.9 2.8 -1.4 -2.0 -0.6 2.7 2.8
Illnesses of siblings 0.4 0.6 1.2 1.1 0.6 -0.0 -0.0 0.9 1.1
Neuroticism score 0.6 1.2 1.7 -1.3 1.2 1.0 0.0 -1.1 -1.3
Weight 0.0 0.2 0.4 0.6 -0.5 -0.4 0.6 -0.2 -0.3
Impedance of arm (right) 1.0 4.8 8.7 -3.0 -0.3 0.5 -1.9 -2.8 -2.8
Arm fat percentage (right) 0.1 0.5 1.0 -0.3 -0.7 -0.5 1.0 -0.8 -0.7
Trunk fat-free mass 0.6 3.7 8.4 2.9 -1.1 -1.3 1.1 2.3 2.1
Hip circumference 0.4 1.7 3.5 -1.6 -1.1 -0.2 -0.1 -1.8 -1.9
Time employed in main current job 1.3 1.5 6.0 0.0 2.4 1.3 0.8 -0.7 -0.2
Alcohol intake versus 10 years previously 0.3 0.5 2.1 -0.7 0.1 0.0 1.5 -0.3 -0.4
Father’s age at death 1.2 1.6 2.5 1.3 -1.5 -1.6 -0.4 1.5 1.0
Worrier / anxious feelings 1.5 2.8 6.3 -1.0 2.4 2.5 -1.0 -1.2 -1.3
Frequency of tiredness / lethargy in last 2 weeks 2.1 3.3 7.3 -2.7 0.6 0.9 -1.3 -2.4 -2.1
Falls in the last year 0.3 0.4 1.1 -0.4 0.8 0.5 -1.0 -0.3 -0.3
Hair/balding pattern: Pattern 3 2.0 3.1 7.9 -1.8 0.1 1.0 -1.9 -2.8 -1.6
Number of live births 0.5 0.7 2.2 0.1 1.5 1.1 0.5 0.4 -0.5
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 1.6 -0.3 -0.0 1.2 -0.2 -1.1 -1.3
Pulse rate 0.8 1.4 2.8 -1.6 0.7 0.7 0.1 -1.7 -1.4
Happiness 1.2 1.5 4.6 -0.7 0.0 1.3 -2.2 -0.8 -1.0
Noisy workplace 2.5 3.1 5.0 -1.8 1.9 2.2 -0.5 -1.8 -1.7
Qualifications: A levels/AS levels or equivalent 3.2 7.0 10.0 2.9 -3.0 -3.2 0.4 2.2 3.0
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 1.3 -0.1 0.7 0.1 1.2 -0.2 -0.2
Mouth/teeth dental problems: Dentures 0.7 1.2 2.0 1.4 0.8 0.5 1.4 1.3 0.9
Asthma 0.9 1.8 6.8 -0.4 2.6 1.9 -0.2 0.5 -0.6
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.2 1.9 -1.3 0.7 1.0 -1.0 -1.2 -1.4
Medication: Cholesterol lowering 0.3 0.5 1.8 1.4 0.0 0.0 -0.7 0.7 0.6
Depression (self-reported) 1.5 1.8 2.8 -1.6 1.3 1.1 -0.1 -1.6 -1.7
Medication: Lansoprazole 1.2 1.3 3.1 -1.0 0.6 1.1 -1.8 -1.1 -1.0
Prospective memory result 1.6 2.0 4.2 -2.0 0.1 0.9 0.1 -2.1 -1.7
Lung cancer (father) 1.9 2.2 3.9 -1.1 1.6 1.7 -2.0 -1.1 -1.1
Illnesses of mother 0.7 0.9 2.3 0.7 0.4 -0.1 1.5 1.1 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 2.3 -0.6 0.0 1.5 -0.5 -1.4 -1.4
Pulse wave Arterial Stiffness index 0.5 0.6 2.9 0.0 0.8 -0.1 1.7 0.5 0.0
Impedance of arm (left) 1.6 7.4 12.6 -3.4 -0.4 0.6 -2.8 -3.5 -3.4
Arm fat mass (right) 0.1 0.4 1.4 0.2 -0.6 -0.5 1.2 -0.4 -0.5
Trunk predicted mass 0.7 3.8 8.5 2.9 -1.1 -1.4 1.1 2.3 2.2
Standing height 0.1 0.8 2.0 -0.0 -1.0 -0.4 -1.4 -0.8 -1.0
Length of working week for main job 1.7 1.8 5.4 1.1 -2.3 -1.7 -0.0 0.3 1.3
Exposure to tobacco smoke at home 0.1 0.1 0.2 -0.2 0.1 -0.2 -0.2 -0.5 -0.3
Breastfed as a baby 0.6 0.8 2.2 0.8 1.5 0.6 0.8 0.8 0.5
Tense / ‘highly strung’ 2.6 4.3 6.4 -2.3 1.5 2.0 -1.3 -2.5 -2.5
Seen doctor (GP) for nerves, anxiety, tension or depression 2.0 3.0 6.6 -1.8 2.6 2.0 0.1 -1.4 -1.4
Hair/balding pattern: Pattern 4 6.0 14.5 31.7 -5.5 -0.4 -0.4 0.3 -5.6 -5.0
Birth weight of first child 0.4 0.7 1.4 0.8 1.2 0.6 0.2 0.7 1.1
Peak expiratory flow (PEF) 0.1 0.3 1.0 1.0 -0.8 0.0 0.4 0.3 -0.1
Pulse wave reflection index 1.9 2.4 4.4 1.8 0.2 -0.8 2.1 1.7 1.8
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.3 -0.4 0.0 0.4 0.3 -0.6 -0.4
Loud music exposure frequency 5.0 5.5 8.3 -2.9 2.0 2.2 -1.0 -2.6 -2.8
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.3 -0.1 -1.2 -0.2 -1.5 -0.9 0.0
Mouth/teeth dental problems: Bleeding gums 3.1 4.0 8.5 -2.9 0.7 1.6 -0.5 -2.5 -2.5
Blood clot in the leg (DVT) 1.3 1.7 4.8 1.0 0.3 0.7 -2.2 1.2 1.5
Medication: Paracetamol 1.6 2.6 6.1 -1.4 2.5 1.9 0.7 -1.0 -1.6
Headache pain in last month 1.7 2.9 5.3 -1.5 2.3 2.1 0.5 -1.3 -1.8
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.2 -0.3 0.3 -0.2 1.1 0.3 0.3
Glaucoma (self-reported) 0.5 0.6 1.4 -0.5 1.0 1.2 0.9 0.0 -0.1
Gout (self-reported) 0.3 0.5 1.1 -0.1 -1.0 -0.6 -1.0 -0.6 -0.3
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 1.8 -0.9 1.4 1.2 0.5 -0.2 -0.9
Medication: Amlodipine 1.2 1.7 3.6 -1.9 0.2 1.0 -0.6 -1.9 -1.2
Medication: Ventolin 100micrograms inhaler 1.2 1.5 6.2 0.2 2.5 1.0 1.0 0.8 -0.1
Birth weight 1.2 2.6 6.9 2.1 -0.4 -0.4 1.0 2.6 1.7
Chronic bronchitis/emphysema (mother) 1.9 2.2 3.3 -1.4 1.2 1.6 -1.4 -1.4 -1.8
High blood pressure (siblings) 2.0 2.8 4.9 -2.2 1.0 1.4 0.1 -2.1 -2.2
Forced vital capacity (FVC), Best measure 0.7 2.7 5.0 -1.1 1.3 2.2 -1.1 -1.8 -2.0
Body fat percentage 0.4 1.6 3.3 -1.3 -0.3 0.2 1.1 -1.7 -1.8
Leg fat percentage (right) 0.2 0.7 2.8 -0.5 -0.1 0.2 1.7 -0.6 -0.9
Arm fat-free mass (right) 0.3 1.6 4.4 2.1 -0.3 -0.6 1.0 1.4 1.3
Exposure to tobacco smoke outside home 0.7 1.0 2.0 -1.1 0.2 0.4 1.4 -1.0 -1.2
Comparative body size at age 10 0.1 0.2 0.5 0.6 0.2 0.4 0.7 -0.4 0.3
Number of full brothers 0.6 0.8 2.3 0.9 -1.5 -0.7 0.4 0.7 0.7
Worry too long after embarrassment 2.8 4.7 5.3 -2.0 2.0 2.3 -2.3 -2.1 -2.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.2 2.1 1.0 -0.8 -1.4 1.3 1.0 1.0
Wheeze or whistling in the chest in last year 2.8 4.9 12.7 -1.2 3.6 3.1 -1.3 -0.7 -1.9
Number of children fathered 0.3 0.3 0.5 -0.2 -0.7 0.0 0.7 -0.7 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 2.1 -0.7 1.2 0.9 -1.5 -0.4 -0.3
Age at first live birth 5.0 8.8 12.8 3.3 -3.4 -3.6 0.7 2.6 3.3
Pulse wave peak to peak time 0.5 0.6 2.7 0.2 -0.9 -0.0 -1.6 -0.4 0.0
Health satisfaction 2.7 3.5 6.3 -2.5 0.8 1.6 -0.4 -2.3 -2.5
Shortness of breath walking on level ground 0.7 0.8 1.9 -0.9 0.6 0.5 1.4 -0.8 -1.0
Qualifications: College or University degree 2.4 7.6 9.2 3.0 -2.9 -3.0 2.0 2.8 2.7
Eye problems/disorders: None of the above 1.2 1.4 3.0 1.6 1.1 0.4 -0.0 1.7 1.3
Mouth/teeth dental problems: Loose teeth 1.3 1.6 5.0 -0.6 -1.5 -1.4 2.2 0.1 -0.0
Emphysema/chronic bronchitis 1.2 1.4 3.8 0.9 1.9 1.5 -0.6 0.9 0.7
Medication for pain relief, constipation, heartburn 1.4 2.3 4.0 1.6 -2.0 -1.8 -0.7 1.1 1.5
Neck or shoulder pain in last month 0.4 0.6 1.8 -0.2 1.0 0.6 1.3 -0.1 -0.5
Medication: Blood pressure 0.2 0.3 0.7 -0.2 -0.2 0.1 -0.6 -0.8 -0.7
Angina (self-reported) 0.9 1.2 3.2 -0.6 1.8 1.2 0.1 -0.7 -1.2
Migraine (self-reported) 2.5 3.0 6.6 -1.7 2.1 2.6 -1.0 -1.2 -1.3
Medication: Ibuprofen 1.4 1.7 1.9 -1.4 1.2 1.4 -1.4 -1.3 -1.1
Medication: Allopurinol 0.6 0.8 1.8 -0.7 -0.9 -0.2 -1.4 -0.9 -0.9
Medication: Omeprazole 1.3 1.6 2.1 -1.5 0.9 1.4 -1.4 -1.0 -1.2
Medication: Seretide 50 evohaler 0.3 0.4 0.6 0.4 -0.7 -0.8 0.1 0.8 0.5
Mean time to correctly identify matches 0.3 0.7 2.0 0.7 0.8 0.0 -0.2 0.9 1.4
Heart disease (mother) 0.4 0.4 0.8 -0.9 -0.4 -0.1 -0.7 -0.6 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 1.5 -1.1 0.9 0.7 0.8 -1.2 -1.1
Whole body fat mass 0.2 0.7 1.6 -0.5 -0.4 0.0 1.0 -1.1 -1.3
Leg fat mass (right) 0.1 0.5 1.7 -0.1 -0.1 0.2 1.3 -0.6 -0.8
Arm predicted mass (right) 0.3 1.7 4.5 2.1 -0.5 -0.8 1.1 1.4 1.3
Pulse rate, automated reading 0.1 0.2 0.5 0.4 -0.7 -0.2 0.1 0.2 0.7
Alcohol intake frequency. 0.3 0.8 4.4 0.1 -0.1 -0.3 2.1 0.4 0.1
Comparative height size at age 10 0.3 1.8 4.6 -0.9 0.4 1.1 -2.1 -1.3 -1.5
Number of full sisters 4.1 4.9 9.5 -1.3 1.6 2.5 -3.1 -2.1 -2.3
Suffer from ‘nerves’ 0.6 0.9 1.7 -1.3 0.9 0.3 -0.5 -0.9 -1.3
Overall health rating 1.4 3.0 6.6 -2.6 0.1 1.0 0.2 -2.0 -2.5
Chest pain or discomfort 0.2 0.3 0.9 0.3 0.5 0.3 -0.5 0.9 0.4
Had major operations 1.3 1.6 2.6 1.4 -1.6 -1.0 0.4 1.2 1.5
Age at last live birth 5.2 7.5 10.8 3.3 -3.1 -3.1 0.0 2.6 2.9
Family relationship satisfaction 1.2 1.5 2.9 -1.2 1.3 1.7 -0.6 -1.3 -1.0
Leg pain on walking 0.8 1.0 4.7 -0.4 -0.2 -0.9 2.2 0.2 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.2 1.1 -0.1 -0.0 -0.9 0.7 0.7
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.5 0.6 0.3 0.7 0.7 0.2 0.4
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 2.0 0.8 0.1 0.1 -1.4 0.4 0.5
Medication: Aspirin 0.4 0.6 2.1 0.5 -0.1 -0.7 1.5 0.2 0.7
Supplements: Vitamin C 0.2 0.3 0.9 -1.0 -0.0 -0.2 -0.4 -0.6 -0.5
Knee pain experienced in last month 0.2 0.2 0.8 -0.6 -0.2 0.1 0.3 -0.4 -0.9
Hypertension (Self-reported) 3.3 9.3 20.7 -4.5 0.1 1.2 0.4 -4.2 -3.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 4.4 -0.2 0.6 1.5 -2.1 -0.3 -0.6
Illnesses of father: Heart disease 1.9 2.6 4.6 1.3 -2.0 -2.2 1.3 1.4 1.2
Illnesses of siblings: Diabetes 0.6 0.7 1.8 1.3 -0.4 -0.4 -0.9 1.0 0.6
Smoking status: Previous 0.2 0.3 0.6 -0.7 0.7 0.1 0.4 -0.5 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 2.7 0.7 1.3 1.3 -1.7 -0.1 -0.0
Whole body fat-free mass 0.4 2.2 5.5 2.4 -1.1 -1.2 0.8 1.5 1.5
Leg fat-free mass (right) 0.2 0.8 2.3 1.5 -1.1 -0.9 0.0 0.4 0.6
Arm fat percentage (left) 0.1 0.4 0.8 -0.4 -0.7 -0.4 0.7 -0.9 -0.8
Average weekly red wine intake 1.2 1.7 4.1 2.0 -0.3 -0.9 0.0 1.5 1.8
Handedness (chirality/laterality): Left-handed 0.9 1.1 5.5 0.4 -0.5 -0.7 2.3 0.2 0.5
Mood swings 0.1 0.2 0.9 0.4 1.0 0.5 -0.0 0.1 0.1
Loneliness, isolation 0.4 0.5 1.4 -0.8 0.6 0.4 1.2 -0.5 -0.7
Long-standing illness, disability or infirmity 1.1 1.6 2.8 -1.7 1.1 1.2 0.9 -0.9 -1.7
Ever had bowel cancer screening 0.9 1.0 2.5 0.8 -1.6 -1.4 0.3 0.7 0.7
Diabetes diagnosed by doctor 0.4 0.6 2.3 -0.2 -1.5 -1.1 -0.1 -0.3 -0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.3 0.3 0.6 0.3 0.0 0.2 0.4
Friendships satisfaction 0.2 0.3 0.7 -0.9 0.2 0.6 0.3 -0.5 -0.5
Qualifications: nursing, teaching 0.7 1.2 2.5 0.8 -0.9 -1.6 1.1 1.1 0.9
Commuting to job workplace: Walk 0.4 0.4 1.0 -0.5 -0.1 -1.0 0.9 0.5 0.5
Eye problems/disorders: Cataract 0.8 1.0 1.3 -1.1 -1.1 -0.7 0.8 -1.1 -1.1
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.8 -1.4 0.3 -0.3 0.4 -0.9 -0.8
Medication for cholesterol 2.3 3.5 8.8 3.0 -0.5 -1.4 -0.5 2.1 2.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 3.0 0.5 -0.5 -1.2 1.7 0.7 0.8
Back pain experienced in last month 0.4 0.5 1.9 -0.8 0.0 0.7 -1.4 -0.3 -0.5
Mineral and other dietary supplements 0.2 0.3 0.8 0.1 -0.9 -0.8 -0.1 -0.5 -0.6
Breast cancer (self-reported) 1.4 1.7 3.1 -0.9 1.5 1.7 0.2 -1.1 -1.8
Asthma (self-reported) 0.9 1.7 5.8 -0.8 2.4 1.8 -0.1 0.1 -0.8
Osteoporosis (self-reported) 0.2 0.2 0.5 -0.4 0.3 0.7 -0.6 0.2 0.1
Osteoarthritis (self-reported) 0.2 0.3 0.9 -0.7 -0.4 -0.1 0.5 -0.2 -0.9
Medication: Aspirin 0.4 0.5 1.5 0.4 -0.3 -0.8 1.2 0.1 0.5
Medication: Gliclazide 0.8 0.9 1.3 0.6 -1.1 -1.1 -0.7 0.7 1.1
Illnesses of father: None of the above (group 1) 2.4 2.9 7.8 -0.7 2.8 2.5 -1.1 -1.0 -1.1
Smoking status: Current 3.1 4.9 9.8 -3.1 0.8 1.5 -0.9 -2.9 -2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 2.0 4.1 -1.1 0.9 1.8 -0.4 -1.5 -2.0
Whole body water mass 0.4 2.2 5.5 2.3 -1.1 -1.2 0.9 1.5 1.5
Leg predicted mass (right) 0.2 0.8 2.2 1.5 -1.1 -0.9 0.1 0.4 0.6
Arm fat mass (left) 0.1 0.4 1.2 0.2 -0.7 -0.5 1.1 -0.4 -0.5
Number of self-reported non-cancer illnesses 3.5 6.0 10.5 -3.2 2.3 2.6 -0.5 -2.4 -2.7
Average weekly champagne plus white wine intake 0.4 0.6 3.5 0.2 0.1 0.2 -1.9 -0.2 -0.2
Miserableness 1.3 2.3 4.3 -1.9 0.6 0.7 1.3 -1.9 -2.1
Guilty feelings 1.9 2.8 8.7 -1.3 2.9 1.7 0.6 -0.9 -1.6
Wears glasses or contact lenses 0.1 0.1 0.6 -0.1 0.0 0.3 -0.8 0.3 0.1
Ever taken oral contraceptive pill 0.5 0.5 1.2 1.1 0.1 0.1 -0.2 0.8 1.1
Hearing aid user 1.3 1.5 2.4 1.1 -1.2 -1.6 1.4 1.1 0.9
Mother’s age at death 0.5 0.7 1.3 1.0 0.1 -0.7 0.1 1.1 1.0
Financial situation satisfaction 0.4 0.4 1.0 -0.4 -0.4 0.6 -0.6 -1.0 -0.8
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.3 -0.5 -0.5 0.3 0.1 -0.4 -0.6
Commuting to job workplace: Public transport 1.1 1.3 2.2 1.1 -1.5 -1.5 0.2 0.9 1.1
Eye problems/disorders: Glaucoma 1.0 1.2 4.3 0.1 1.2 1.0 2.1 0.4 0.3
Medication: Blood pressure 5.5 10.5 26.1 -5.1 0.7 1.9 0.5 -4.2 -3.8
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.7 -0.5 -0.3 -0.6 1.3 0.0 -0.6
Supplements: Fish oil (including cod liver oil) 0.3 0.3 0.9 -1.0 0.6 0.3 0.5 -0.6 -0.4
High cholesterol (Self-reported) 0.1 0.1 0.2 0.3 0.4 0.2 0.1 0.5 -0.0
Medication: Bendroflumethiazide 2.6 3.9 9.5 -2.9 -0.0 0.9 0.5 -3.1 -2.1
Medication: Paracetamol 2.4 3.7 5.3 -2.3 2.1 1.9 -0.5 -1.9 -2.2
Medication: Lisinopril 0.2 0.3 1.4 0.1 -1.2 -0.5 0.2 -0.4 0.1
Medication: Atorvastatin 0.8 0.9 3.1 0.4 1.8 0.8 0.7 1.1 0.4
Illnesses of father: High blood pressure 0.9 1.1 2.2 -1.5 -1.0 -0.5 0.6 -1.3 -1.1
Alcohol drinker status: Never 1.2 1.4 2.7 1.4 0.0 -0.6 0.9 1.6 1.6
Ever smoked 2.4 4.2 8.0 -2.8 1.7 1.7 -0.7 -2.2 -2.4
Basal metabolic rate 0.2 1.4 3.6 1.9 -0.9 -0.9 0.8 1.1 1.0
Leg fat percentage (left) 0.3 1.1 3.4 -0.8 0.5 0.5 1.8 -0.8 -1.1
Arm fat-free mass (left) 0.4 2.0 4.9 2.2 -0.1 -0.5 1.4 1.7 1.4
Number of operations (self-reported) 0.6 0.9 4.0 0.4 -0.7 -0.6 2.0 0.5 0.6
Average weekly beer plus cider intake 1.5 2.1 3.6 -1.2 1.3 1.8 -1.9 -1.3 -1.1
Irritability 2.3 3.9 6.7 1.6 -1.4 -2.3 2.6 1.6 2.1
Risk taking 0.3 0.4 0.9 0.5 -0.3 -0.7 0.7 0.9 0.6
Ever had prostate specific antigen (PSA) test 2.0 2.3 4.9 2.2 -0.0 -1.1 0.7 2.1 1.6
Fractured/broken bones in last 5 years 4.6 5.9 12.5 -1.4 3.4 3.5 -2.2 -1.4 -1.6
Age started oral contraceptive pill 0.3 0.3 1.6 -0.0 0.0 0.5 -1.3 0.1 -0.3
Diastolic blood pressure, automated reading 1.0 3.0 5.5 -1.7 1.7 2.4 -0.8 -1.8 -1.7
Ever depressed for a whole week 3.1 3.8 9.8 -1.2 3.1 2.6 -0.9 -1.1 -1.7
Unable to work because of sickness or disability 0.4 0.6 0.9 -1.0 0.7 0.9 0.3 -0.7 -0.7
Commuting to job workplace: Cycle 0.9 1.1 2.9 1.0 0.8 -0.7 -0.2 1.3 1.7
Myopia 0.4 0.6 1.3 -0.7 0.6 0.8 -0.5 -0.7 -1.2
Vascular/heart problems diagnosed by doctor 2.4 6.4 14.6 3.8 0.1 -0.6 -0.7 3.6 3.2
Cholesterol lowering medication 0.9 1.4 2.1 -1.3 1.4 1.0 0.8 -0.9 -1.4
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.8 -1.0 0.5 0.8 -1.3 -0.8 -0.7
Pain experienced in last month 2.1 3.5 7.7 2.6 0.0 -1.1 0.4 2.2 2.8
Supplements: Calcium 0.8 0.9 2.3 -0.6 0.8 1.5 -1.2 -0.5 -0.4
Basal cell carcinoma (self-reported) 2.0 2.4 3.8 -1.6 1.2 1.5 -1.3 -2.0 -1.7
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.0 0.7 -0.3 -1.0 0.6 0.5 0.5
Deep venous thrombosis (DVT) (self-reported) 1.8 2.3 5.6 1.3 0.6 0.7 -2.4 1.5 1.7
Heart disease (siblings) 0.4 0.5 1.5 -0.5 -0.8 0.0 -1.2 -0.2 -0.8
Alcohol drinker status: Previous 0.5 0.5 1.0 -1.0 -0.6 -0.2 -0.4 -0.9 -1.0
Pack years of smoking 1.3 1.9 3.3 -1.8 -0.3 0.5 -1.4 -1.8 -1.6
Impedance of whole body 1.2 6.0 11.1 -3.3 0.9 1.5 -1.5 -3.1 -3.2
Leg fat mass (left) 0.2 0.6 1.4 -0.4 0.4 0.6 1.2 -0.9 -1.0
Arm predicted mass (left) 0.4 2.1 5.2 2.3 -0.4 -0.7 1.5 1.6 1.4