TWAS hub - CCDC117

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0350	0.0180	0.00610	0.010	0.018	0.001	0.018	0.006	2.0e-02	0.00230	2.3e-01	2.6e-03	4.9e-02
2	GTEx	Cells Transformed fibroblasts	0.0950	0.0390	0.00058	0.008	NA	0.013	NA	0.015	8.2e-02	NA	3.6e-02	NA	2.4e-02
3	GTEx	Skin Sun Exposed Lower leg	0.0670	0.0270	0.00170	0.026	NA	0.026	NA	0.018	2.9e-03	NA	2.8e-03	NA	1.1e-02
4	METSIM	Adipose	0.0508	0.0204	0.00060	0.045	0.014	0.022	0.022	0.033	2.1e-07	0.00250	2.4e-04	2.2e-04	8.1e-06
5	YFS	Blood	0.0280	0.0109	0.00012	0.019	0.011	0.014	0.015	0.023	4.5e-07	0.00014	1.7e-05	9.8e-06	3.1e-08
6	TCGA	Lung Adenocarcinoma	0.0307	0.0177	0.00790	0.007	0.010	0.006	NA	0.009	4.6e-02	0.02300	5.1e-02	NA	2.5e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Hair/balding pattern: Pattern 4	12.9	31.2	51.7	-6.0	-7.2	-6.8	-2.2	-1.5	-6.8
Current tobacco smoking	5.7	9.4	14.8	-3.9	-3.8	-2.8	-2.2	-1.4	-3.5
Smoking status: Current	5.6	8.8	14.4	-3.8	-3.7	-2.7	-2.1	-1.4	-3.4
Medication: Blood pressure	5.1	9.7	25.4	-4.3	-3.1	-2.1	-0.2	-0.2	-5.0
Maternal smoking around birth	5.0	7.3	16.7	-3.9	-1.9	-2.5	1.0	-0.8	-4.1
Bilateral oophorectomy (both ovaries removed)	4.8	5.5	10.0	-2.3	-2.6	-3.2	-0.6	0.9	-3.1
Heel T-Score	4.5	35.8	74.3	4.9	-5.2	-8.6	-6.3	7.0	1.3
Ovarian Cancer	4.1	5.5	10.8	1.4	2.1	2.7	2.3	3.3	1.8
Smoking Status	4.0	9.7	18.0	-4.2	-4.1	-2.3	-1.8	-1.5	-3.5
High blood pressure	4.0	11.2	28.7	-5.0	-2.7	-1.7	0.9	-1.2	-5.4
Hypertension (Self-reported)	3.7	10.2	27.2	-4.8	-2.4	-1.8	0.6	-1.3	-5.2
Taking other prescription medications	3.6	5.5	16.8	-4.1	-2.1	-1.7	-0.3	-1.1	-2.8
Medication: Bendroflumethiazide	3.6	5.5	15.4	-2.5	-2.3	-2.5	-0.2	0.1	-3.9
Pain all over the body in last month	3.5	3.7	7.9	-1.8	-2.2	-2.4	-0.3	0.7	-2.8
Blood Red Count	3.4	32.7	40.3	5.9	6.3	5.6	4.0	5.9	6.2
Eye problems/disorders: Diabetes related eye disease	3.4	3.7	6.5	-2.3	-2.5	-1.0	-0.7	-1.7	-2.5
Vascular/heart problems diagnosed by doctor	3.3	9.0	23.3	4.3	2.6	1.8	-0.7	1.1	4.8
Waist Hip Ratio (WHR)	3.2	14.5	34.2	0.5	4.2	5.8	3.6	4.4	1.4
Schizophrenia (2014)	3.0	6.6	11.4	-3.4	-2.7	-2.7	1.2	1.0	-3.4
Heel bone mineral density (BMD) T-score, automated (right)	3.0	6.8	12.8	3.1	-1.7	-3.2	-2.1	3.6	1.1
Eye problems/disorders: None of the above	3.0	3.4	5.9	2.2	2.4	0.9	1.1	1.3	2.4
Heel bone mineral density (BMD) T-score, automated (left)	2.9	6.7	11.1	3.1	-1.6	-3.3	-2.5	3.1	1.1
Commuting to job workplace: Cycle	2.9	3.5	6.0	2.4	2.3	1.7	-0.9	-0.4	2.5
Crohns Disease (2012)	2.8	4.5	9.9	1.8	2.3	3.1	1.5	0.7	2.5
Deep venous thrombosis (DVT) (self-reported)	2.7	3.5	7.2	1.8	2.0	1.7	-0.4	-1.8	2.7
Prostate Cancer	2.6	3.7	10.2	1.1	2.1	1.9	3.2	1.7	0.3
Supplements: Vitamin C	2.6	3.1	7.8	-0.8	-2.8	-1.9	-2.0	-0.6	-1.4
Health satisfaction	2.5	3.2	5.8	-2.4	-1.8	-2.3	0.4	-0.5	-2.2
Impedance of arm (left)	2.4	11.2	32.4	-1.7	-4.3	-5.7	-0.5	-2.7	-2.3
Medication for cholesterol	2.4	3.6	9.8	3.1	1.1	0.4	-0.7	-0.8	3.1
Loud music exposure frequency	2.3	2.5	6.1	-2.5	-1.9	-1.1	0.6	-0.3	-1.9
Medication: Metformin	2.2	3.1	5.5	-2.4	-2.2	-0.1	0.7	-1.7	-2.1
Medication: Atenolol	2.2	2.7	5.4	-2.3	-1.8	-1.5	1.0	-0.3	-2.1
Heart disease (mother)	2.2	2.7	6.7	-1.2	-1.1	-1.5	-2.6	-2.1	-0.5
Overall health rating	2.2	4.7	12.9	-3.6	-2.2	-2.1	-0.2	0.3	-2.5
Cardiovascular Disease	2.1	6.9	17.9	-4.1	-1.9	-1.4	0.1	-1.1	-4.2
Other serious medical condition/disability diagnosed by doctor	2.1	2.7	4.8	-2.0	-2.1	-1.6	-0.5	0.1	-2.2
Alcohol usually taken with meals	2.1	3.4	6.8	2.5	1.6	0.7	-2.6	0.1	2.1
Age at last live birth	2.1	3.1	8.1	2.8	2.0	1.6	-0.1	0.2	2.0
Blood clot in the leg (DVT)	2.0	2.6	4.5	1.5	1.7	1.3	-0.7	-1.9	2.1
Age at first live birth	2.0	3.5	8.6	2.9	1.8	2.2	-0.7	-0.4	1.9
Average weekly red wine intake	2.0	2.9	6.5	1.8	1.6	0.9	-2.6	-0.8	1.9
Number of self-reported non-cancer illnesses	2.0	3.5	11.5	-3.4	-1.0	-0.2	-0.5	-1.7	-2.3
Ever smoked	2.0	3.6	5.2	-2.3	-2.1	-1.1	-2.0	-1.9	-1.7
Crohns Disease (2017)	1.9	4.2	9.8	1.2	1.9	3.1	1.4	0.9	2.7
Fasting Glucose	1.9	2.3	4.6	-1.5	-2.1	-1.5	0.8	0.6	-1.9
Type 2 Diabetes (T2D) (2018)	1.9	3.5	6.5	-2.5	-2.4	-0.3	0.2	-1.5	-2.5
Mouth/teeth dental problems: Bleeding gums	1.9	2.4	6.4	-2.5	-1.2	-1.6	0.1	-0.9	-1.9
Miserableness	1.9	3.4	8.7	-1.6	-1.6	-3.0	-0.5	1.3	-2.1
Pain experienced in last month	1.9	3.1	6.0	2.5	1.7	2.1	-1.1	-0.4	2.0
Schizophrenia (2018)	1.8	3.7	6.1	-2.5	-2.4	-2.0	0.6	1.0	-2.3
Reaction Time	1.8	3.4	11.5	3.4	1.5	-0.2	0.7	0.9	2.2
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	4.4	1.0	2.1	1.4	0.9	-0.8	1.6
Impedance of arm (right)	1.8	8.6	26.1	-1.3	-4.0	-5.1	-0.5	-2.0	-1.8
Medication: Paracetamol	1.8	2.8	9.1	-1.9	-1.3	-3.0	-0.2	1.0	-1.3
Ever had prostate specific antigen (PSA) test	1.8	2.0	4.5	1.9	1.7	0.9	-0.7	0.1	2.1
Systolic Blood Pressure	1.7	8.5	25.5	-3.3	-1.7	-2.0	2.1	1.8	-5.0
Systolic blood pressure, automated reading	1.7	5.0	14.1	-2.9	-1.6	-1.1	1.7	1.1	-3.8
Fluid intelligence score	1.7	3.4	8.1	2.8	1.6	1.5	-1.0	-0.7	2.5
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	6.1	-2.5	-1.7	-1.0	-0.9	-1.3	-2.0
Hair/balding pattern: Pattern 3	1.7	2.6	4.0	-1.0	-2.0	-2.0	1.1	-1.4	-1.9
Exposure to tobacco smoke outside home	1.7	2.3	5.0	-1.3	-2.2	-1.6	0.3	1.3	-1.7
Medication: Allopurinol	1.7	2.3	5.1	-1.9	0.6	-1.6	-0.6	-2.2	-1.3
Number of treatments/medications taken	1.6	2.8	8.9	-3.0	-0.5	-1.5	0.3	-0.3	-2.3
Townsend deprivation index at recruitment	1.6	2.3	7.0	-2.6	-1.3	-0.3	1.0	-0.9	-1.8
Diabetes (self-reported)	1.6	2.4	5.9	-2.1	-1.2	0.4	-0.3	-2.4	-1.6
Qualifications: A levels/AS levels or equivalent	1.6	3.6	12.5	3.5	1.9	-0.1	-1.1	0.2	2.1
Breastfed as a baby	1.6	2.0	3.9	-0.0	0.6	1.7	2.0	1.8	1.2
Birth weight	1.6	3.6	8.2	2.7	1.8	-0.1	-1.4	0.9	2.9
Number of full sisters	1.6	2.0	4.5	-1.7	-1.6	-0.9	0.7	-2.1	-0.7
Irritable Bowel Disease (IBD)	1.5	3.5	9.9	1.5	1.8	3.2	1.2	0.9	1.8
Relative age of first facial hair	1.5	3.2	7.9	-2.2	-1.7	-2.8	0.1	-0.6	-1.8
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	5.1	-2.0	-1.9	-1.0	0.0	-0.3	-2.2
Hearing difficulty/problems with background noise	1.5	2.4	5.2	-2.1	-1.0	-1.8	0.3	-0.6	-2.3
Prospective memory result	1.5	1.8	4.1	-1.6	-0.8	-2.0	0.2	-0.6	-1.8
Medication: Amlodipine	1.5	2.1	4.1	-1.8	-1.9	-0.6	-0.4	-1.0	-2.0
Number of children fathered	1.5	1.7	3.8	-1.2	-0.9	-0.1	1.9	0.7	-1.9
Illnesses of father: High blood pressure	1.5	1.9	3.0	-1.2	-1.1	-1.4	-1.4	-1.2	-1.7
Bipolar Disorder or Schizophrenia	1.4	3.3	6.0	-1.9	-2.5	-1.8	0.2	1.4	-2.2
Major Depression (MDD)	1.4	1.7	3.5	1.1	1.6	1.1	1.3	-0.3	1.9
Trunk fat percentage	1.4	5.8	12.7	-2.8	-3.6	-2.9	-0.3	-0.3	-2.4
Pack years of smoking	1.4	2.0	3.3	-1.5	-1.7	-1.5	-0.5	-1.2	-1.8
Breast Cancer	1.3	3.0	7.2	0.2	-0.7	-1.9	-2.7	-2.5	0.5
Ever used hormone-replacement therapy (HRT)	1.3	1.7	4.7	-2.2	-1.5	-0.6	-0.4	-1.2	-1.1
Vitamin and mineral supplements	1.3	1.7	3.3	1.3	1.3	0.8	0.7	1.6	1.8
Allergy	1.3	3.0	9.5	-1.9	-1.6	-1.5	-0.3	0.5	-3.1
Glaucoma (self-reported)	1.3	1.6	4.2	-2.0	-0.8	0.4	0.7	-0.8	-1.8
High blood pressure (siblings)	1.3	1.9	4.6	-2.1	-1.2	-1.0	0.2	0.4	-2.1
Leg pain on walking	1.3	1.6	4.6	-0.4	-0.1	-1.7	-2.2	1.2	-0.7
Ever depressed for a whole week	1.3	1.5	3.1	-1.7	-1.5	0.6	1.8	0.8	-0.3
HbA1C	1.2	1.3	6.7	0.8	0.6	0.1	2.6	-0.0	0.1
Neuroticism (2016)	1.2	1.8	3.4	-1.8	-0.9	-1.9	0.3	-0.5	-1.6
Triglycerides	1.2	1.9	6.9	0.4	0.5	1.2	2.6	1.6	-0.4
Pack years adult smoking proportion	1.2	1.8	2.7	-1.4	-1.5	-1.4	-0.7	-1.2	-1.6
Past tobacco smoking	1.2	2.2	5.6	2.4	1.6	0.8	1.2	1.1	1.5
Hair/balding pattern: Pattern 2	1.2	1.5	2.5	1.1	1.6	1.2	-1.4	-1.1	0.7
Medication: Ramipril	1.2	1.6	4.1	-0.7	-0.4	-0.7	2.0	1.1	-1.7
Pulse rate	1.2	2.1	4.2	-2.0	-2.0	0.3	0.8	0.3	-1.8
Medication: Paracetamol	1.2	2.0	5.7	-1.1	-0.6	-1.7	1.1	2.4	-0.7
Medication: Ventolin 100micrograms inhaler	1.2	1.5	4.3	0.5	0.1	2.1	-0.5	1.8	1.1
Medication for pain relief, constipation, heartburn	1.2	2.0	4.2	2.0	0.1	1.1	-1.4	-1.7	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.5	3.7	-0.1	0.7	1.6	1.9	-1.2	0.8
Long-standing illness, disability or infirmity	1.2	1.9	6.6	-2.6	-0.9	0.0	0.2	0.9	-1.7
Medication: Gliclazide	1.2	1.4	4.8	-0.3	0.4	2.2	-0.2	-1.8	0.1
Financial situation satisfaction	1.2	1.4	2.5	-1.3	-1.4	0.0	1.6	0.2	-1.5
Cholesterol lowering medication	1.2	1.8	5.7	-2.4	-1.1	0.2	0.6	1.0	-1.6
Impedance of whole body	1.2	6.3	17.5	-1.6	-3.4	-4.2	0.5	-1.1	-2.1
Type 2 Diabetes (T2D) (2012)	1.1	1.3	2.7	-1.6	-0.8	0.8	1.3	-0.2	-1.4
Severe depression (siblings)	1.1	1.2	3.4	-0.9	-0.2	-1.8	-1.5	-0.7	0.4
Relative age voice broke	1.1	1.7	3.3	-1.6	-1.1	-1.8	0.9	-1.2	-1.0
Nervous feelings	1.1	2.0	3.2	-1.8	-1.6	-1.3	1.4	-0.6	-1.6
Tense / ‘highly strung’	1.1	1.7	4.8	-0.9	-1.1	-2.2	0.5	0.1	-1.8
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	4.4	2.1	0.8	-1.7	0.7	-1.2	0.3
Medication: Ibuprofen	1.1	1.3	3.5	-0.8	-0.1	-1.9	-1.4	-1.4	0.3
Eye problems/disorders: Glaucoma	1.1	1.4	3.3	-1.8	-0.4	1.2	0.9	0.1	-1.6
Supplements: Fish oil (including cod liver oil)	1.1	1.5	3.5	-0.9	-1.9	-1.2	-0.9	-0.0	-1.5
Mouth/teeth dental problems: Dentures	1.0	1.7	4.0	0.8	2.0	1.3	-0.5	1.4	1.2
Gout (self-reported)	1.0	1.4	3.9	-1.1	0.5	-1.5	-0.0	-2.0	-1.0
Body fat percentage	1.0	4.1	8.6	-2.6	-2.9	-2.1	0.1	-0.1	-2.2
Shortness of breath walking on level ground	1.0	1.2	2.4	-1.4	-1.0	-0.6	-0.2	1.2	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.0	-1.5	-1.0	0.0	-0.7	-0.5	-1.7
Illnesses of siblings: Diabetes	1.0	1.3	3.0	-0.4	1.2	1.7	1.5	-0.4	0.6
Handedness (chirality/laterality): Left-handed	1.0	1.2	3.1	0.5	0.5	-0.6	-1.5	1.8	-1.0
Diabetes diagnosed by doctor	1.0	1.7	3.6	-1.9	-1.1	0.9	-0.2	-1.4	-1.6
Eye problems/disorders: Cataract	1.0	1.2	3.0	-1.3	-1.7	-0.6	-0.4	0.4	-1.3
Back pain experienced in last month	1.0	1.4	3.9	-0.6	-0.5	-0.7	-2.0	-1.9	0.0
Average weekly beer plus cider intake	1.0	1.4	4.6	-0.8	-1.0	0.2	2.2	-1.0	-1.1
Fractured/broken bones in last 5 years	1.0	1.3	4.1	-0.7	0.5	1.5	2.0	-0.8	0.4
Heart disease (siblings)	1.0	1.2	3.4	-1.7	-1.8	-0.3	-0.1	-0.7	-0.6
Alcohol drinker status: Previous	1.0	1.2	2.7	-0.8	-1.2	-1.6	0.3	-1.0	-1.1
Chronotype (morning person)	0.9	2.1	3.5	1.6	1.7	1.6	1.0	0.5	1.9
Sensitivity / hurt feelings	0.9	1.5	4.6	-2.2	-1.1	0.0	1.0	-0.1	-1.4
Supplements: Zinc	0.9	1.0	2.2	0.5	0.3	0.0	-1.5	-1.1	1.4
Hayfever, allergic rhinitis or eczema	0.9	2.0	6.0	1.9	0.6	1.2	0.4	0.9	2.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.0	3.2	-1.8	-1.5	-0.8	0.1	0.1	-0.3
Illnesses of siblings	0.9	1.2	2.9	1.7	1.2	0.3	-0.4	0.0	1.7
Hip circumference	0.9	3.8	7.2	-2.6	-2.7	-1.9	-1.1	-1.0	-1.7
Medication: Lansoprazole	0.9	1.1	2.8	-1.3	-0.1	-0.2	1.7	-1.1	-0.7
Birth weight of first child	0.9	1.7	3.8	1.3	0.9	1.9	1.6	0.7	1.0
Pulse wave reflection index	0.9	1.2	2.6	1.0	1.0	1.6	0.2	1.3	0.8
Qualifications: College or University degree	0.9	2.7	5.6	2.2	2.4	1.0	-1.2	0.5	1.8
Emphysema/chronic bronchitis	0.9	1.0	3.5	0.3	0.8	1.0	1.9	0.4	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	4.5	-1.1	-0.7	-1.2	2.1	1.5	-1.1
Mother’s age at death	0.9	1.2	3.3	1.8	0.9	0.7	-0.4	-0.2	1.5
Alcohol drinker status: Never	0.9	1.1	1.8	1.3	1.2	1.1	-0.4	0.7	1.3
Basal cell carcinoma (self-reported)	0.9	1.1	2.6	-1.6	-1.1	-1.0	0.8	0.2	-1.0
Alzheimer’s Disease (in father)	0.8	0.9	2.7	-0.7	-0.5	-0.8	0.2	1.1	-1.6
Primary Biliary Cirrhosis	0.8	1.2	2.5	-1.2	-1.1	-1.6	-0.4	-0.5	-1.1
Rheumatoid Arthritis	0.8	1.1	2.5	1.3	1.6	0.3	-0.6	-0.7	1.1
Ulcerative Colitis	0.8	1.2	2.9	1.4	1.3	1.7	0.1	-0.4	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.4	-0.9	-0.9	-1.4	0.5	-0.2	-1.6
Qualifications: CSEs or equivalent	0.8	1.1	2.2	0.5	1.3	1.2	0.8	1.5	0.4
Serious illness, injury or assault to yourself	0.8	1.0	4.0	-2.0	-0.3	0.3	0.6	-0.5	-1.0
Trunk fat mass	0.8	3.6	7.6	-2.5	-2.8	-2.0	-0.3	-0.1	-1.8
Qualifications: None of the above	0.8	1.8	5.5	-2.3	-1.5	-0.2	1.1	-0.2	-1.3
Asthma	0.8	1.6	5.0	-0.3	1.1	2.2	0.4	0.4	1.8
Chronic bronchitis/emphysema (mother)	0.8	1.0	3.0	-1.0	-0.1	-1.7	0.9	0.5	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	3.2	0.5	0.3	1.8	1.5	-0.2	0.4
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.6	0.7	0.8	-0.8	1.6	1.0	-0.1
Loneliness, isolation	0.8	1.1	2.9	-1.7	-0.8	-0.6	-0.6	-0.1	-1.4
Commuting to job workplace: Walk	0.8	0.9	1.9	0.8	0.8	1.4	-0.7	0.1	1.3
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.1	-0.4	-1.5	-1.4	-0.9	0.4	-0.3
Schizophrenia vs Biploar Disorder	0.7	0.9	3.0	-1.7	-0.1	-0.1	-0.2	-0.8	-1.3
HDL Cholesterol	0.7	1.1	3.0	-0.7	-1.7	-1.7	-0.2	-0.3	0.4
Medication: Co-codamol	0.7	0.8	2.9	-1.7	-0.5	-0.2	-0.3	0.7	-1.0
Age when periods started (menarche)	0.7	1.7	4.5	2.0	0.9	-0.5	-0.9	0.1	2.1
Multivitamins +/- minerals	0.7	0.9	1.8	-0.8	-0.5	-0.9	-0.8	-1.4	-1.0
Chronic bronchitis/emphysema (father)	0.7	0.8	2.4	1.3	-0.3	0.1	-0.5	-0.5	1.6
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.4	0.1	0.9	1.4	0.1	0.4	1.6
Medication: Simvastatin	0.7	1.0	2.7	-1.0	-0.0	1.1	1.7	-0.0	-0.8
Alcohol intake versus 10 years previously	0.7	1.1	3.5	-1.2	-1.9	-0.3	-0.4	0.7	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	3.7	-1.0	-0.6	-1.9	-0.5	-0.5	0.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.4	0.3	-1.0	-1.3	-1.5	1.2	-0.0
Mean time to correctly identify matches	0.7	1.4	4.9	2.2	0.9	-0.1	0.6	0.4	1.5
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.2	1.0	0.4	0.5	0.5	-0.9	1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.2	0.4	0.6	1.2	1.5	0.6	-0.1
Wears glasses or contact lenses	0.7	0.8	2.9	-0.4	-0.0	0.6	-1.2	-1.7	0.3
Ever taken oral contraceptive pill	0.7	0.8	1.8	1.2	0.3	1.4	-0.3	-0.7	0.8
Hearing aid user	0.7	0.8	2.0	1.2	0.3	0.9	-0.2	1.4	0.8
Commuting to job workplace: Public transport	0.7	0.9	3.3	0.8	0.2	1.1	-1.8	-0.4	0.3
Pain type(s) experienced in last month: Hip pain	0.7	0.8	2.9	-1.7	0.3	0.9	-0.6	0.2	-0.8
Irritability	0.7	1.1	3.1	1.7	0.9	0.0	-1.4	1.0	0.0
Diastolic blood pressure, automated reading	0.7	2.1	8.2	-1.3	0.4	0.9	2.9	0.2	-1.2
Unable to work because of sickness or disability	0.7	1.0	2.3	-1.2	-1.3	0.3	0.2	-0.1	-1.5
Depression (Nagel 2018)	0.6	0.9	2.0	-1.4	-1.0	-0.0	0.4	0.8	-1.3
Age at First Birth	0.6	0.8	3.4	1.8	1.0	0.3	0.7	0.1	0.2
Coronary Artery Disease (CAD)	0.6	0.7	1.5	-0.7	-1.2	0.7	0.1	-0.2	-1.2
Mean Putamen Volume	0.6	0.7	1.7	-1.3	-0.4	1.1	-0.3	-1.0	0.4
Allergy or Eczema	0.6	1.5	3.6	1.4	-0.2	-0.1	0.8	1.9	1.7
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.3	-1.1	-0.3	-0.1	0.3	1.5	-1.1
Diabetes (father)	0.6	0.7	1.7	1.3	0.6	1.0	0.9	0.5	0.2
High blood pressure (mother)	0.6	0.9	2.4	-0.8	-0.5	-0.1	1.4	0.5	-1.5
Financial difficulties in last 2 years	0.6	0.8	2.4	-0.5	0.2	-0.5	-0.8	1.6	-1.0
Time employed in main current job	0.6	0.7	1.7	0.7	0.3	-0.6	1.2	1.3	-0.0
Happiness	0.6	0.8	1.9	-0.9	-1.4	-0.5	-0.1	-1.2	-0.4
Medication: Cholesterol lowering	0.6	1.0	2.1	0.9	1.4	0.9	0.9	-0.6	1.0
Headache pain in last month	0.6	1.0	3.3	-0.6	0.3	-1.0	1.3	1.8	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.1	1.5	0.7	-0.6	-0.2	1.3	0.6
Medication: Blood pressure	0.6	1.0	3.8	-0.8	0.2	0.8	2.0	-0.6	-0.8
Whole body fat mass	0.6	2.5	5.7	-2.4	-2.2	-1.3	0.2	0.1	-1.7
Had major operations	0.6	0.6	1.5	1.1	0.3	1.2	-0.7	-0.2	0.8
Family relationship satisfaction	0.6	0.8	2.1	-1.2	-0.6	0.3	0.5	-0.7	-1.4
Qualifications: nursing, teaching	0.6	1.0	2.0	1.1	1.4	1.1	0.7	0.8	0.7
Breast cancer (self-reported)	0.6	0.7	3.0	-0.6	-0.3	-0.9	0.3	1.7	-0.2
Illnesses of father: None of the above (group 1)	0.6	0.8	1.8	0.2	1.0	0.8	1.3	1.1	0.2
Average weekly champagne plus white wine intake	0.6	0.8	1.8	1.3	0.9	-0.2	0.8	-0.4	1.2
Medication: Atorvastatin	0.6	0.7	2.3	0.1	1.5	0.4	-0.7	0.4	1.1
Myopia	0.6	0.8	2.1	-1.4	-1.2	-0.7	0.5	-0.0	-0.9
Respiratory disease	0.5	1.1	3.6	0.1	0.9	1.9	0.2	0.5	1.4
Average weekly spirits intake	0.5	0.6	1.3	-0.7	-0.5	-1.1	-0.2	0.6	-1.0
Hearing difficulty/problems: Yes	0.5	0.7	2.4	-1.0	-0.1	-1.6	-0.1	0.3	-0.9
Diabetes (mother)	0.5	0.6	1.5	0.7	-1.2	0.1	-0.2	-1.2	-0.5
Supplements: Glucosamine	0.5	0.7	3.4	-0.3	-0.7	0.3	-0.0	-1.9	-0.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.1	-0.0	-0.8	-1.0	-0.7	0.7	-1.0
Impedance of leg (left)	0.5	2.3	3.5	-1.3	-1.4	-1.7	1.8	0.7	-1.9
Father’s age at death	0.5	0.6	2.5	0.5	-0.6	-0.4	-1.6	-0.0	0.7
Number of live births	0.5	0.8	1.5	-0.8	-0.3	1.0	1.1	1.2	-0.2
Noisy workplace	0.5	0.6	1.3	-1.2	-0.7	-0.7	-0.5	-0.6	-0.8
Illnesses of mother	0.5	0.6	2.8	0.5	0.3	0.6	0.6	1.7	0.2
Pulse wave Arterial Stiffness index	0.5	0.6	1.1	-0.8	-1.0	-0.2	-1.1	1.0	-0.1
Length of working week for main job	0.5	0.6	1.1	1.1	-0.9	-0.8	-0.4	-0.8	-0.2
Pulse wave peak to peak time	0.5	0.6	0.9	0.9	1.0	0.1	0.7	-1.0	0.2
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.5	-0.7	-0.9	0.8	-0.1	0.6	-1.2
Migraine (self-reported)	0.5	0.6	1.4	-1.2	-0.2	-0.7	1.1	0.4	-0.4
Medication: Omeprazole	0.5	0.5	1.9	-1.4	-0.6	-0.1	0.6	-0.5	-0.6
Asthma (self-reported)	0.5	0.9	2.9	-0.5	0.7	1.7	0.2	0.2	1.3
Leg fat percentage (left)	0.5	1.7	4.2	-2.0	-1.4	-0.1	1.0	0.9	-1.4
Leg fat mass (left)	0.5	1.9	5.7	-2.4	-1.5	-0.4	0.7	0.5	-1.5
Ulcerative Colitis (UC)	0.4	0.8	2.3	1.0	1.2	1.5	0.0	0.3	0.4
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.6	0.9	0.8	0.9	-1.1	-0.3	1.3
Lung FVC	0.4	2.0	4.3	-2.1	-0.6	-1.8	1.0	1.4	-1.1
Impedance of leg (right)	0.4	1.9	3.1	-1.4	-1.1	-1.8	1.5	-0.2	-1.8
Waist circumference	0.4	1.4	3.0	-1.4	0.1	1.7	1.0	1.6	-0.4
Number of incorrect matches in round	0.4	0.7	1.3	-1.1	-1.0	-0.7	0.3	0.0	-1.1
Had menopause	0.4	0.5	1.6	-0.5	-0.9	0.2	-1.2	-0.6	0.1
Forced vital capacity (FVC)	0.4	1.5	4.7	-1.3	-1.0	-2.2	1.0	0.1	-0.9
Neuroticism score	0.4	0.8	2.0	-0.6	-0.6	-1.1	0.4	0.7	-1.4
Arm fat percentage (right)	0.4	1.6	4.6	-1.4	-2.1	-1.3	-0.2	-0.4	-1.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	5.3	-0.6	-0.7	-2.3	0.7	0.5	-0.7
Lung cancer (father)	0.4	0.4	0.8	0.2	0.8	0.6	0.9	-0.3	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	5.5	-0.7	-0.4	-2.4	0.1	0.3	-0.8
Leg fat percentage (right)	0.4	1.3	4.2	-2.0	-1.1	-0.2	0.8	0.3	-1.3
Worry too long after embarrassment	0.4	0.7	1.4	-1.2	-0.2	-0.4	0.9	-0.7	-1.2
Wheeze or whistling in the chest in last year	0.4	0.7	1.7	-1.2	-0.2	1.3	0.9	0.1	0.7
Neck or shoulder pain in last month	0.4	0.6	1.9	-0.1	-0.1	-1.1	0.4	1.4	-0.2
Leg fat mass (right)	0.4	1.6	5.3	-2.3	-1.3	-0.4	0.5	0.2	-1.4
Alcohol intake frequency.	0.4	1.0	3.6	-0.7	-1.1	0.3	0.2	1.9	-0.8
Comparative height size at age 10	0.4	2.0	4.8	-2.2	-1.0	-0.8	0.4	-2.1	-0.9
Arm fat percentage (left)	0.4	1.6	4.3	-1.4	-2.1	-1.4	-0.3	-0.6	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.7	-0.0	-0.7	-1.3	-0.9	0.0	-0.8
Osteoporosis (self-reported)	0.4	0.5	1.7	0.1	0.7	0.7	1.3	-0.4	0.2
Osteoarthritis (self-reported)	0.4	0.5	1.8	-0.9	0.4	0.2	1.4	0.4	-0.1
Guilty feelings	0.4	0.7	2.2	-0.7	-0.5	-0.1	-0.3	1.5	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	-1.0	-0.5	0.1	1.0	-0.7	-0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.2	0.5	0.5	-0.2	0.9	1.1	0.4
Bipolar Disorder (2018)	0.3	0.5	1.1	-0.0	-1.0	-0.4	-0.5	1.1	-0.7
Depressed Affect (Nagel 2018)	0.3	0.6	1.8	-0.8	-0.3	-1.3	0.3	0.6	-0.9
Body Mass Index (BMI) (2010)	0.3	0.4	1.6	0.2	-0.3	0.4	0.5	1.3	0.0
Lupus	0.3	0.5	1.7	-0.8	-0.4	-0.2	0.3	0.4	-1.3
Height	0.3	6.1	11.2	-3.4	-2.6	-2.6	-1.7	-2.6	-1.5
Hypothyroidism (self reported)	0.3	0.6	1.3	0.5	0.5	0.6	-0.5	1.1	1.0
Lung FEV1/FVC ratio	0.3	1.6	4.0	2.0	1.4	-0.6	-1.2	0.2	1.2
Hand grip strength (left)	0.3	0.8	2.8	-0.6	0.8	-0.1	1.7	0.1	-0.9
Angina	0.3	0.4	1.2	-1.1	-0.5	-0.5	0.8	-0.2	-0.6
Medication for hormone replacement therapy	0.3	0.3	0.6	-0.7	-0.5	-0.8	-0.2	0.2	-0.5
Stomach or abdominal pain in last month	0.3	0.4	0.9	0.6	0.2	0.2	0.8	0.7	0.9
Medication: Levothyroxine sodium	0.3	0.5	2.5	-0.0	0.2	-0.2	-0.0	1.6	0.5
Had other major operations	0.3	0.4	0.8	-0.9	-0.8	-0.3	0.2	0.9	-0.4
Heart attack	0.3	0.4	0.9	0.6	0.5	0.0	0.7	0.9	0.5
Trunk fat-free mass	0.3	1.5	4.9	0.2	1.7	2.2	-0.4	0.5	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.8	0.3	0.6	0.3	0.8	0.9	-0.2
Depression (self-reported)	0.3	0.4	0.9	-0.6	-0.6	-0.9	0.1	0.2	-0.9
Arm fat mass (right)	0.3	1.2	2.8	-1.7	-1.6	-0.6	-0.2	0.2	-1.1
Trunk predicted mass	0.3	1.6	5.1	0.2	1.7	2.3	-0.5	0.5	0.9
Standing height	0.3	3.1	5.2	-1.9	-1.8	-2.3	-1.4	-1.6	-1.2
Exposure to tobacco smoke at home	0.3	0.4	1.1	-0.4	-1.1	-0.5	0.6	-0.0	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.9	-0.9	-0.6	-0.9	0.4	0.1	-0.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.2	-0.5	-0.5	-1.0	-1.1	0.8	0.0
Forced vital capacity (FVC), Best measure	0.3	1.1	3.8	-1.3	-0.8	-1.9	0.6	-0.0	-0.7
Number of full brothers	0.3	0.4	0.8	-0.8	-0.3	0.9	0.5	-0.1	-0.8
Chest pain or discomfort	0.3	0.5	1.2	0.9	0.5	0.6	0.1	0.4	1.1
Medication: Aspirin	0.3	0.4	0.8	-0.4	0.3	0.7	0.9	0.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.3	0.4	0.3	-0.3	-1.0	-1.5	0.7
Ever had bowel cancer screening	0.3	0.3	0.6	0.7	-0.6	0.2	0.6	-0.8	0.1
Friendships satisfaction	0.3	0.4	1.9	-0.5	-1.4	0.2	0.2	0.2	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.0	-0.1	-0.1	0.1	0.7	1.0	-0.5
Arm fat mass (left)	0.3	1.1	2.6	-1.5	-1.6	-0.7	-0.1	0.2	-1.0
Medication: Lisinopril	0.3	0.4	0.9	-0.3	0.6	0.7	-0.0	-0.6	-0.9
Arm fat-free mass (left)	0.3	1.3	4.8	-0.5	1.1	2.2	-0.2	1.1	0.6
Risk taking	0.3	0.5	1.8	-0.6	-0.1	-0.6	-1.4	-0.1	-0.5
Supplements: Calcium	0.3	0.3	1.0	-0.3	-0.6	-0.4	-0.2	-1.0	-0.5
Arm predicted mass (left)	0.3	1.4	5.1	-0.5	1.1	2.3	0.2	1.3	0.5
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.1	1.0	0.9	0.3	-0.7	-0.5	1.0
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	0.4	0.3	-0.6	0.2	-0.4	0.6
Blood Platelet Count	0.2	2.7	10.5	0.2	1.1	0.4	3.2	1.5	1.5
Hair Pigment	0.2	4.9	12.9	-0.0	2.7	3.6	2.2	1.5	1.4
Tanning	0.2	2.5	6.2	1.2	1.9	1.3	-1.4	0.1	2.5
Hand grip strength (right)	0.2	0.7	2.6	-0.7	0.2	0.7	1.6	-0.1	-0.7
Fed-up feelings	0.2	0.4	1.5	-0.6	0.1	-0.5	-1.2	-0.2	-0.4
Mouth/teeth dental problems	0.2	0.3	0.5	0.6	-0.7	0.1	0.3	-0.7	0.6
Weight	0.2	0.8	2.6	-1.6	-1.1	-0.4	-0.5	-0.1	-0.7
Worrier / anxious feelings	0.2	0.4	1.2	0.5	-0.0	-0.8	1.1	0.4	-0.0
Falls in the last year	0.2	0.3	0.7	0.2	0.5	-0.4	-0.2	-0.9	0.7
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.9	-0.5	-0.1	-0.5	0.6	-0.1	-0.9
Arm fat-free mass (right)	0.2	1.0	3.3	-0.7	1.1	1.8	-0.3	0.7	0.3
Angina (self-reported)	0.2	0.3	0.8	-0.9	-0.5	-0.2	0.6	-0.3	-0.6
Arm predicted mass (right)	0.2	1.0	3.6	-0.7	1.0	1.9	-0.4	0.7	0.2
Suffer from ‘nerves’	0.2	0.3	1.2	-0.3	-0.6	-0.4	-1.1	-0.2	-0.1
Knee pain experienced in last month	0.2	0.4	1.1	-1.0	-0.7	0.0	0.4	0.6	-0.3
Illnesses of father: Heart disease	0.2	0.3	0.7	0.3	0.3	0.7	-0.8	-0.2	0.3
Smoking status: Previous	0.2	0.3	0.9	-1.0	-0.4	0.1	-0.3	-0.7	-0.2
Mineral and other dietary supplements	0.2	0.3	0.8	-0.3	0.1	0.1	0.9	0.7	0.3
Medication: Aspirin	0.2	0.3	0.7	-0.3	0.2	0.5	0.9	0.5	-0.6
High cholesterol (Self-reported)	0.2	0.3	0.9	-0.7	0.3	1.0	0.5	-0.5	0.1
Number of operations (self-reported)	0.2	0.3	1.1	0.7	0.2	0.3	-0.5	1.0	-0.3
Age started oral contraceptive pill	0.2	0.3	1.1	0.3	-0.2	0.3	-0.4	-0.5	1.1
Neuroticism (Nagel 2018)	0.1	0.2	0.5	-0.4	-0.1	-0.5	0.7	0.1	-0.5
Worry (Nagel 2018)	0.1	0.1	0.6	0.2	0.2	-0.1	0.8	-0.1	0.1
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	0.6	0.6	-0.5	0.5	0.2	0.3
Bipolar Disorder (2011)	0.1	0.1	0.2	-0.5	-0.4	-0.1	-0.2	-0.0	-0.3
LDL Cholesterol	0.1	0.2	0.6	-0.0	-0.5	0.6	0.8	-0.4	0.1
Blood Eosinophil Count	0.1	0.9	3.4	-0.3	-0.0	-0.6	-1.2	0.0	1.9
Blood White Count	0.1	1.1	3.9	0.3	-0.9	-2.0	-1.1	0.7	-0.5
BMI	0.1	0.6	1.1	-0.8	-1.0	0.4	-0.8	1.0	-0.4
Neuroticism	0.1	0.2	0.7	-0.2	-0.2	-0.8	0.3	0.2	-0.8
Ever had hysterectomy (womb removed)	0.1	0.2	0.6	-0.1	-0.2	-0.4	0.2	0.8	0.1
Leg fat-free mass (left)	0.1	0.6	1.4	-1.2	-0.6	-0.4	-1.0	-0.8	-0.3
Average weekly fortified wine intake	0.1	0.1	0.4	-0.4	-0.2	0.2	-0.7	0.4	-0.1
Sitting height	0.1	0.9	2.8	0.7	0.7	-0.4	-1.1	0.5	1.7
Body mass index (BMI)	0.1	0.3	0.7	-0.9	-0.3	0.7	0.0	0.7	-0.3
Leg predicted mass (left)	0.1	0.6	1.2	-1.1	-0.6	-0.3	-1.1	-0.7	-0.2
Peak expiratory flow (PEF)	0.1	0.1	0.5	-0.7	0.1	0.2	0.1	0.5	-0.1
Comparative body size at age 10	0.1	0.3	1.0	0.2	0.0	-0.7	1.0	0.6	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	0.4	0.3	-0.5	0.1	-0.3	0.5
Medication: Seretide 50 evohaler	0.1	0.1	0.5	0.2	0.3	0.7	-0.0	0.1	0.2
Pulse rate, automated reading	0.1	0.4	1.8	0.4	0.3	1.4	0.5	-0.1	0.4
Whole body fat-free mass	0.1	0.5	1.6	-0.4	0.8	1.2	-0.8	0.2	0.4
Leg fat-free mass (right)	0.1	0.4	1.3	-0.8	-0.5	-0.2	-1.1	-0.5	-0.0
Whole body water mass	0.1	0.5	1.6	-0.4	0.8	1.3	-0.7	0.3	0.4
Leg predicted mass (right)	0.1	0.4	1.2	-0.8	-0.6	-0.2	-1.1	-0.4	-0.1
Basal metabolic rate	0.1	0.3	0.7	-0.8	0.2	0.8	-0.6	0.1	0.1
Mood swings	0.0	0.1	0.2	0.1	0.5	0.1	0.2	-0.1	0.2

Hub : Genes

CCDC117

Models

Trait associations