Best TWAS P=2.73e-15 · Best GWAS P=6.91e-22 conditioned to 4.06e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | RP3-511B24.6 | 0.21 | 0.00 | lasso | 5 | 0.00 | 0.25000 | -3.5 | 5.3 | 9.6e-08 | -0.61 | 0.06 | 0.12 | FALSE |
| 2 | GTEx | Thyroid | LPIN3 | 0.29 | 0.08 | lasso | 10 | 0.04 | 0.00033 | -7.8 | 6.6 | 5.0e-11 | -0.76 | 0.94 | 0.01 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CHD6 | 0.02 | 0.00 | blup | 118 | 0.01 | 0.01050 | -4.3 | 5.5 | 3.0e-08 | -0.50 | 0.15 | 0.40 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ZHX3 | 0.04 | 0.02 | lasso | 2 | 0.02 | 0.00239 | -7.8 | -7.9 | 2.7e-15 | 0.84 | 0.03 | 0.23 | TRUE |