TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Taking other prescription medications
:
←
→
chr14:74,424,938-76,089,054
Best TWAS P=7.94e-10 · Best GWAS P=1.36e-10 conditioned to 1
74.4M
74.6M
74.8M
75M
75.2M
75.4M
75.6M
75.8M
76M
0
2
4
6
8
10
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
CommonMind
Brain Pre-frontal Cortex
DLST
0.09
0.11
lasso
2
0.11
4.0e-13
-6.3
6.2
7.9e-10
-0.98
0.01
0.99
TRUE
2
GTEx
Skin Not Sun Exposed Suprapubic
RPS6KL1
0.08
0.08
enet
11
0.07
1.5e-04
5.0
6.0
2.3e-09
-0.94
0.02
0.98
FALSE
3
GTEx
Testis
AREL1
0.20
0.14
enet
34
0.13
2.1e-06
5.3
5.9
2.8e-09
-0.85
0.21
0.79
FALSE
4
The Cancer Genome Atlas
Breast Invasive Carcinoma
RPS6KL1
0.03
0.02
lasso
3
0.02
8.5e-06
5.3
5.4
6.2e-08
-0.85
0.06
0.93
FALSE
5
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
RPS6KL1
0.04
0.04
lasso
3
0.03
1.8e-04
5.4
5.2
1.9e-07
-0.86
0.05
0.92
FALSE