Best TWAS P=7.94e-10 · Best GWAS P=1.36e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DLST | 0.09 | 0.11 | lasso | 2 | 0.11 | 4.0e-13 | -6.3 | 6.2 | 7.9e-10 | -0.98 | 0.01 | 0.99 | TRUE |
| 2 | GTEx | Skin Not Sun Exposed Suprapubic | RPS6KL1 | 0.08 | 0.08 | enet | 11 | 0.07 | 1.5e-04 | 5.0 | 6.0 | 2.3e-09 | -0.94 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Testis | AREL1 | 0.20 | 0.14 | enet | 34 | 0.13 | 2.1e-06 | 5.3 | 5.9 | 2.8e-09 | -0.85 | 0.21 | 0.79 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RPS6KL1 | 0.03 | 0.02 | lasso | 3 | 0.02 | 8.5e-06 | 5.3 | 5.4 | 6.2e-08 | -0.85 | 0.06 | 0.93 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RPS6KL1 | 0.04 | 0.04 | lasso | 3 | 0.03 | 1.8e-04 | 5.4 | 5.2 | 1.9e-07 | -0.86 | 0.05 | 0.92 | FALSE |