Best TWAS P=2.68e-10 · Best GWAS P=7.75e-10 conditioned to 0.102
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | LEPR | 0.46 | 0.19 | lasso | 9 | 0.25 | 1.0e-08 | -5.4 | -5.4 | 5.5e-08 | -0.39 | 0.19 | 0.65 | FALSE |
| 2 | NTR | Blood | LEPROT | 0.10 | 0.05 | lasso | 6 | 0.09 | 1.1e-26 | 6.2 | -6.3 | 2.7e-10 | -0.83 | 0.00 | 1.00 | TRUE |
| 3 | YFS | Blood | LEPROT | 0.40 | 0.25 | enet | 52 | 0.38 | 2.0e-133 | 5.4 | -5.8 | 7.8e-09 | -0.77 | 0.21 | 0.79 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LEPR | 0.04 | 0.01 | blup | 142 | 0.03 | 1.3e-06 | 6.2 | -5.4 | 7.7e-08 | -0.55 | 0.01 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LEPR | 0.05 | 0.00 | blup | 142 | 0.02 | 2.0e-03 | -4.0 | -5.8 | 7.4e-09 | -0.59 | 0.04 | 0.48 | FALSE |