TWAS hub - LEPR

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0680	0.0240	9.7e-05	0.048	0.042	0.062	0.047	0.052	1.7e-06	6.1e-06	5.1e-08	1.8e-06	6.0e-07
2	GTEx	Cells EBV-transformed lymphocytes	0.4550	0.1020	1.6e-04	0.194	NA	0.212	NA	0.250	6.4e-07	NA	1.7e-07	NA	1.0e-08
3	METSIM	Adipose	0.1596	0.0397	1.2e-07	0.080	0.085	0.075	0.088	0.076	5.3e-12	9.9e-13	2.2e-11	4.1e-13	1.6e-11
4	ROSMAP	Brain Pre-frontal Cortex	0.0911	0.0281	9.7e-07	0.066	0.059	0.047	0.057	0.056	6.9e-09	4.6e-08	1.1e-06	7.6e-08	1.1e-07
5	TCGA	Breast Invasive Carcinoma	0.0389	0.0153	3.2e-05	0.007	0.029	0.026	NA	0.022	1.3e-02	1.3e-06	3.6e-06	NA	1.8e-05
6	TCGA	Colon Adenocarcinoma	0.2190	0.0900	9.0e-04	0.017	0.066	0.037	NA	0.015	3.5e-02	1.1e-04	3.3e-03	NA	4.1e-02
7	TCGA	Head and Neck Squamous Cell Carcinoma	0.1336	0.0526	1.4e-06	0.016	0.068	0.054	NA	0.051	5.5e-03	3.9e-08	1.1e-06	NA	1.9e-06
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0490	0.0217	1.3e-03	0.003	0.020	0.001	NA	0.007	1.5e-01	2.0e-03	2.3e-01	NA	5.3e-02
9	TCGA	Lung Squamous Cell Carcinoma	0.1021	0.0370	2.6e-06	0.067	0.048	0.065	NA	0.060	4.0e-08	3.7e-06	7.8e-08	NA	2.2e-07
10	TCGA	Stomach Adenocarcinoma	0.1480	0.0560	5.2e-04	0.034	0.047	0.053	NA	0.049	1.7e-03	2.3e-04	1.0e-04	NA	1.8e-04
11	TCGA	Thyroid Carcinoma	0.0950	0.0400	1.7e-04	0.014	0.057	0.065	NA	0.042	1.3e-02	3.3e-06	6.0e-07	NA	5.9e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Age when periods started (menarche)	7.7	18.6	33.4	-4.2	-5.4	-4.3	-4.3	-5.4	-4.5	-4.6	-5.8	-3.4	-2.0	-0.4
Comparative body size at age 10	7.2	19.8	52.1	3.5	7.2	4.2	4.9	4.0	5.1	5.5	5.0	1.7	2.5	2.1
Blood White Count	5.0	37.3	151.3	-9.3	3.7	-5.3	-12.3	-4.9	2.1	-6.9	-0.5	-2.1	0.4	-7.1
Diabetes (father)	4.7	5.8	10.9	-2.0	-1.7	-3.3	-2.2	-2.5	-2.2	-2.4	-2.3	-1.7	-2.5	-3.3
Number of live births	4.4	6.2	11.0	1.8	3.0	2.0	1.2	2.7	3.1	3.3	2.8	2.0	3.1	1.2
Pulse wave reflection index	4.1	5.1	13.1	3.6	1.2	2.2	1.6	2.7	1.3	2.2	2.7	2.5	0.3	2.5
Seen doctor (GP) for nerves, anxiety, tension or depression	3.3	5.1	9.7	1.6	2.8	2.8	0.6	3.1	2.0	2.2	2.7	2.3	1.1	2.2
Type 2 Diabetes (T2D) (2012)	3.2	3.7	10.1	-1.1	-0.6	-2.4	-0.6	-2.9	-1.2	-1.8	-1.6	-1.9	-2.1	-3.2
Sensitivity / hurt feelings	3.1	5.4	10.0	-2.2	-1.0	-3.0	-2.1	-2.8	-1.6	-3.0	-2.2	-3.2	-0.8	-2.3
Pulse rate	3.0	5.0	15.9	-4.0	-0.4	-2.9	-2.5	-2.2	-0.6	-2.1	-2.1	-0.6	-0.7	-3.0
Wears glasses or contact lenses	2.8	3.3	5.6	-1.2	-1.4	-2.4	-1.8	-2.0	-2.2	-2.3	-2.2	-1.4	-1.5	-0.2
Financial difficulties in last 2 years	2.7	3.6	11.9	-1.0	3.5	0.8	-0.7	1.6	3.3	2.1	1.4	1.6	1.1	-1.2
Diabetes diagnosed by doctor	2.6	4.2	10.4	-1.0	-0.8	-2.5	-2.0	-2.4	-1.4	-3.0	-1.1	-2.3	-0.9	-3.2
Type 2 Diabetes (T2D) (2018)	2.5	4.6	11.3	-1.1	-0.2	-2.8	-2.4	-2.6	-1.0	-2.9	-1.3	-2.0	-1.6	-3.4
Basal cell carcinoma (self-reported)	2.4	2.9	8.4	-2.1	-2.9	-0.4	-1.3	-1.7	-1.1	-2.1	-2.4	-1.8	-0.3	-0.3
Diabetes (self-reported)	2.3	3.5	9.1	-0.8	-1.1	-2.1	-2.2	-2.3	-1.4	-3.0	-1.2	-2.0	-0.8	-2.2
Average weekly red wine intake	2.3	3.4	7.1	-2.2	-1.2	-1.6	-2.4	-2.3	-0.4	-2.7	-2.3	-2.1	-0.4	-0.2
Commuting to job workplace: Cycle	2.3	2.8	6.7	0.6	0.9	2.2	-0.7	2.1	1.4	1.7	1.3	1.8	2.6	1.7
Lung FVC	2.2	11.4	33.4	1.8	0.9	4.9	1.5	4.9	2.2	3.3	1.9	3.3	2.9	5.8
Qualifications: None of the above	2.2	4.8	14.4	-1.5	-1.9	-3.8	-1.1	-2.6	-2.1	-2.1	-2.4	-1.4	-1.3	-2.5
Eye problems/disorders: Diabetes related eye disease	2.1	2.4	6.7	-0.1	-1.1	-1.2	1.3	-1.8	-2.6	-2.2	-1.2	-2.0	1.2	0.2
Guilty feelings	2.1	3.2	6.0	2.2	2.0	1.8	1.7	2.1	0.8	1.8	1.8	0.4	1.5	2.5
Cardiovascular Disease	2.0	6.7	15.5	-0.8	-2.2	-3.6	-0.7	-2.7	-2.3	-3.0	-1.9	-3.2	-1.9	-3.9
Relative age of first facial hair	2.0	4.0	10.9	-2.3	-1.8	-1.2	-3.3	-1.9	-1.9	-2.8	-2.0	-2.1	0.4	-0.5
High blood pressure (mother)	2.0	2.8	4.9	-1.7	-1.7	-2.1	-2.2	-1.5	-1.7	-1.6	-2.0	-0.3	-1.7	-1.0
Medication: Amlodipine	2.0	2.8	7.0	-0.6	-2.7	-2.5	-0.6	-1.8	-2.3	-1.7	-1.7	-0.3	-1.0	-1.2
Waist Hip Ratio (WHR)	1.9	8.6	18.7	-4.3	0.3	-4.1	-2.1	-4.3	-1.8	-2.2	-2.5	-2.9	-0.7	-3.5
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	6.6	2.4	0.8	2.6	1.1	1.6	1.0	0.3	1.6	0.3	-0.0	1.5
Chest pain or discomfort	1.9	2.7	7.2	0.9	1.6	1.4	-0.6	2.7	1.8	1.4	2.2	2.6	-0.2	0.3
Relative age voice broke	1.8	2.8	10.7	-1.4	-1.4	-1.0	-3.3	-1.6	-1.0	-2.8	-0.9	-1.4	-0.2	-0.1
Pulse wave Arterial Stiffness index	1.8	2.2	4.8	1.4	1.4	1.4	1.1	1.9	1.0	1.3	1.4	1.9	-0.0	2.2
Pulse wave peak to peak time	1.8	2.1	4.9	-1.4	-1.3	-1.3	-1.0	-1.9	-0.9	-1.3	-1.4	-2.0	0.2	-2.2
Smoking Status	1.7	4.1	19.0	1.9	3.0	0.2	4.4	1.2	1.4	2.8	1.3	0.8	0.2	0.1
Medication: Co-codamol	1.7	1.9	10.0	-1.6	-0.0	-1.3	-0.8	-1.3	0.7	-1.4	-0.2	-1.2	0.7	-3.2
Alcohol usually taken with meals	1.7	2.7	7.8	-1.3	-2.8	-1.4	-1.2	-1.4	-2.1	-2.2	-1.6	-0.7	-1.4	-0.6
Noisy workplace	1.7	2.1	3.8	1.9	1.6	0.6	1.7	1.4	1.1	1.9	1.5	1.1	1.5	0.7
Age started oral contraceptive pill	1.7	2.1	5.3	1.0	0.7	1.3	-0.6	1.7	2.1	1.1	1.4	2.3	-0.3	1.8
Chronic bronchitis/emphysema (father)	1.6	1.8	7.2	2.7	0.1	1.5	2.3	1.1	0.1	0.4	1.3	0.0	1.1	1.1
Hair/balding pattern: Pattern 2	1.6	2.1	6.5	0.7	0.5	1.3	0.7	2.2	1.2	1.6	0.9	1.5	1.1	2.6
Father’s age at death	1.6	2.1	6.0	1.3	1.0	1.2	1.2	1.5	0.3	2.5	1.2	0.8	1.9	1.7
Ever highly irritable/argumentative for 2 days	1.6	1.9	4.7	1.7	1.1	0.9	1.5	1.2	0.3	1.9	0.9	1.1	2.2	1.5
Medication: Ibuprofen	1.6	2.0	4.0	1.1	1.2	2.0	1.8	1.6	1.8	1.5	1.9	0.2	0.1	0.4
Ever had bowel cancer screening	1.6	1.9	3.9	-0.8	-2.0	-1.6	-1.3	-1.9	-1.5	-1.6	-1.1	-1.4	-0.7	-0.1
Ever had hysterectomy (womb removed)	1.5	1.7	4.5	2.0	-0.8	1.6	0.8	0.8	0.4	1.1	0.9	0.2	1.9	2.1
Falls in the last year	1.5	2.0	4.7	-0.8	-0.1	-1.6	-0.9	-0.7	-0.3	-2.0	-1.0	-1.8	-2.0	-2.2
Birth weight of first child	1.5	2.8	4.6	2.1	1.0	2.1	2.0	2.1	1.4	1.3	2.0	1.2	0.5	1.5
Leg pain on walking	1.5	1.8	4.0	1.3	2.0	1.5	2.0	1.1	1.4	1.2	1.6	0.2	1.0	-0.1
Lupus	1.4	2.1	4.9	1.5	0.8	1.4	1.8	1.9	1.0	2.2	1.3	1.7	0.4	1.2
Rheumatoid Arthritis	1.4	2.0	3.7	1.9	1.2	1.8	1.7	0.5	0.7	1.7	0.3	-0.7	1.8	1.6
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	3.6	1.8	-0.6	1.9	-0.3	1.6	1.1	0.9	1.5	1.0	-0.2	1.6
HDL Cholesterol	1.3	2.2	4.2	1.3	-0.4	2.1	1.0	2.0	0.8	1.7	0.7	1.1	1.9	2.0
Townsend deprivation index at recruitment	1.3	1.8	4.5	1.2	1.1	1.2	1.1	1.5	0.9	1.8	0.9	1.6	0.5	2.1
Medication: Levothyroxine sodium	1.3	2.2	4.1	0.8	-2.0	-1.4	-1.8	-1.5	-2.0	-1.6	-1.5	-1.3	0.5	-1.1
Breastfed as a baby	1.3	1.6	4.6	-1.0	-1.7	-0.6	-1.2	-1.5	-1.0	-2.2	-1.5	-1.3	-0.7	0.4
Number of children fathered	1.3	1.5	3.5	1.5	0.5	1.0	1.5	1.7	0.6	1.4	1.9	1.4	0.6	-0.3
Pulse rate, automated reading	1.3	4.2	10.8	-3.0	-0.3	-3.1	-1.7	-2.1	-0.9	-1.8	-1.8	-0.8	-1.0	-3.3
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	4.4	0.5	2.1	1.3	1.0	1.3	1.0	1.7	0.5	0.7	0.3	1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.5	1.0	1.3	1.9	1.4	1.2	0.6	1.1	0.7	-0.0	1.6	1.1
Systolic blood pressure, automated reading	1.2	3.5	10.3	0.4	-1.8	-2.5	-0.7	-2.3	-3.2	-2.1	-1.3	-1.9	-1.2	-1.0
Had other major operations	1.2	1.5	4.0	0.3	-2.0	-0.6	-1.1	-1.1	-1.5	-1.6	-1.4	-1.2	0.4	1.1
Pain all over the body in last month	1.2	1.3	5.1	0.9	1.2	0.6	1.0	1.0	1.6	-0.1	1.4	-0.2	0.3	-2.2
Prospective memory result	1.2	1.5	3.4	1.2	1.9	1.4	0.8	0.7	1.4	1.3	1.2	0.0	1.8	0.1
Peak expiratory flow (PEF)	1.2	2.7	5.3	1.3	1.1	2.3	1.4	2.3	0.8	1.5	1.8	1.3	1.3	2.1
Loud music exposure frequency	1.2	1.4	3.5	-0.6	0.6	-1.9	-1.4	-0.8	1.3	-0.5	-1.1	0.3	-1.7	-1.4
Overall health rating	1.2	2.5	7.2	-0.7	-0.0	-2.3	-1.8	-0.8	-0.6	-2.0	-0.2	-0.8	-2.7	-2.4
Supplements: Vitamin C	1.2	1.4	4.0	-0.6	0.2	-1.1	-1.5	-0.8	-1.4	-1.0	-0.4	-0.5	-1.8	-2.0
Eye problems/disorders: Glaucoma	1.2	1.4	3.2	-0.5	-1.1	-1.5	-1.0	-1.7	-1.8	-0.4	-1.2	-0.1	-1.5	0.9
Medication: Blood pressure	1.2	2.3	4.8	0.4	-1.7	-1.5	-1.5	-1.4	-2.2	-2.0	-1.6	-1.3	-1.3	-1.0
Medication: Lisinopril	1.2	1.6	4.4	-1.3	-0.2	-0.6	-2.0	-1.1	-0.6	-1.6	-1.0	-2.1	0.6	-1.3
Schizophrenia vs Biploar Disorder	1.1	1.5	5.2	-0.2	-1.3	-1.0	-0.0	-1.2	-0.7	-0.9	-2.0	-1.1	-2.3	-0.7
Maternal smoking around birth	1.1	1.5	5.5	1.7	1.4	0.7	2.3	1.4	0.8	0.5	1.8	0.2	-0.3	-0.2
Hearing difficulty/problems with background noise	1.1	1.7	6.5	0.8	1.2	0.4	0.7	1.5	2.5	1.8	1.4	1.4	-0.6	0.1
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.4	6.3	1.8	0.4	1.3	1.4	2.1	1.4	1.4	2.5	1.5	1.4	-0.5
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	5.5	1.0	2.3	0.6	0.9	0.3	1.5	0.8	0.7	0.5	0.6	1.7
Alcohol intake versus 10 years previously	1.1	1.7	4.1	-1.7	-0.7	-1.7	0.1	-1.4	-0.9	-1.0	-1.2	-1.1	-1.2	-2.0
Qualifications: A levels/AS levels or equivalent	1.1	2.4	5.7	-0.4	1.4	2.4	-0.0	1.7	0.9	1.7	1.1	1.5	2.0	2.1
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	3.4	0.4	0.9	1.6	1.1	1.7	1.8	1.3	1.6	0.5	0.0	-0.0
Medication: Paracetamol	1.1	1.8	4.0	2.0	0.1	1.4	1.1	1.8	1.7	0.9	1.9	1.3	0.1	-0.9
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.8	0.7	1.6	1.6	0.4	1.2	1.9	1.7	1.5	1.2	0.1	1.3
Had major operations	1.1	1.3	4.0	-0.2	-0.7	-0.9	-1.1	-1.1	-0.9	-2.0	-1.6	-1.4	-1.0	-0.7
Hypertension (Self-reported)	1.1	3.1	5.0	-0.2	-1.9	-2.1	-1.3	-1.6	-1.9	-2.2	-1.7	-1.6	-1.9	-2.0
Depression (Nagel 2018)	1.0	1.5	3.7	-0.9	1.7	-1.4	-1.9	-1.1	0.0	-1.2	-0.7	-1.0	-1.2	-1.2
Blood Eosinophil Count	1.0	7.6	35.0	5.9	3.0	1.8	1.6	1.9	1.1	2.3	4.0	1.1	2.5	-0.5
Current tobacco smoking	1.0	1.6	8.1	-0.2	2.8	-0.1	2.5	-0.4	0.0	1.3	-0.2	-0.7	0.8	-0.5
Serious illness, injury or assault to yourself	1.0	1.2	2.1	1.2	0.7	1.3	-1.2	1.5	1.4	0.9	0.4	0.9	0.6	1.4
High blood pressure	1.0	2.7	5.5	0.1	-1.7	-1.9	-1.1	-1.4	-1.7	-2.4	-1.4	-1.8	-1.8	-1.8
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	4.9	-0.9	0.3	-1.0	-2.0	-0.5	-0.1	-1.2	-0.7	-0.7	-2.2	-0.3
Medication: Simvastatin	1.0	1.5	3.2	-0.6	-1.2	-1.8	-0.7	-1.8	-1.7	-1.1	-1.1	-1.3	-0.8	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	6.3	0.2	1.8	1.8	0.7	2.5	1.7	2.3	1.6	2.4	1.6	2.0
Forced vital capacity (FVC), Best measure	1.0	3.8	7.0	0.4	1.8	2.2	0.7	2.6	1.3	2.4	1.6	2.4	2.0	2.6
Comparative height size at age 10	1.0	5.3	12.7	2.1	3.6	1.8	3.2	2.3	2.9	2.7	2.0	0.8	0.9	1.2
Handedness (chirality/laterality): Left-handed	1.0	1.2	4.2	1.1	-0.4	1.3	0.7	2.0	0.6	1.0	1.4	1.4	-0.1	0.3
Smoking status: Current	1.0	1.5	7.8	-0.2	2.8	-0.1	2.4	-0.1	0.1	1.5	0.2	-0.3	0.8	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	4.5	1.0	0.9	1.6	1.3	2.1	0.4	1.7	1.5	1.5	1.5	1.7
Fractured/broken bones in last 5 years	1.0	1.2	4.2	-2.0	0.8	-0.6	-2.0	-0.9	0.8	-0.7	-0.9	-0.6	-0.1	-1.2
Medication: Omeprazole (e.g. Zanprol)	1.0	1.3	5.3	2.3	-1.6	0.6	1.2	0.6	-1.5	-0.3	-0.1	0.3	-0.1	1.3
Mean Putamen Volume	0.9	1.1	2.9	1.3	-0.4	0.8	0.2	1.6	0.6	0.9	0.8	0.7	1.2	1.7
Average weekly spirits intake	0.9	1.1	5.8	0.7	-0.9	-1.4	-0.4	-0.0	-1.4	-1.0	0.3	0.1	-0.4	-2.4
Supplements: Glucosamine	0.9	1.1	2.6	1.5	0.6	1.1	1.6	1.0	0.8	1.0	1.2	0.8	0.3	1.0
Worrier / anxious feelings	0.9	1.6	3.6	-1.9	-1.1	-1.1	-0.6	-1.6	-0.9	-1.3	-1.5	-1.1	-1.5	-0.9
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	6.8	0.5	1.1	2.3	1.2	2.6	0.9	2.0	1.4	2.2	1.1	2.5
Mouth/teeth dental problems: Dentures	0.9	1.5	7.0	0.4	2.6	-0.5	1.9	-0.1	0.2	1.3	0.7	-0.2	1.8	-0.7
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	4.7	0.2	1.4	2.2	0.1	1.1	0.4	1.1	0.3	1.2	-0.3	2.1
Medication for pain relief, constipation, heartburn	0.9	1.5	3.9	-2.0	0.5	-1.6	-1.6	-1.4	-1.1	-0.8	-1.8	-0.2	-0.2	0.3
Illness, injury, bereavement, stress in last 2 years	0.9	1.2	2.8	-1.1	-1.2	-1.2	-0.2	-1.4	-1.0	-1.7	-0.8	-1.0	-1.2	0.2
Knee pain experienced in last month	0.9	1.3	4.0	0.5	1.4	1.0	-0.2	1.6	1.2	0.8	1.5	0.6	2.0	-0.6
Osteoporosis (self-reported)	0.9	1.1	2.6	-1.4	-1.3	-0.2	-1.6	-0.4	-1.3	-1.4	-1.0	-0.4	0.4	-1.1
Medication: Gliclazide	0.9	1.0	5.2	1.3	-0.5	0.2	1.2	-0.2	-0.8	0.3	0.7	-0.8	2.3	0.3
Miserableness	0.9	1.5	4.8	0.5	2.2	0.4	0.5	0.6	1.1	1.6	1.3	0.1	2.1	0.8
Pain type(s) experienced in last month: Hip pain	0.9	1.2	4.0	-1.9	-0.7	-1.2	-1.3	-0.5	-0.3	-0.7	-0.7	-0.1	0.2	-2.0
Medication: Atorvastatin	0.9	1.1	3.0	1.5	-0.4	1.1	0.7	1.7	0.2	0.4	0.4	1.7	-0.6	1.3
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	6.6	0.5	-2.6	-0.9	-0.4	-0.5	-1.8	-0.4	-0.7	-0.5	0.1	-0.0
Heart disease (siblings)	0.9	1.1	5.0	0.5	0.4	-1.1	2.2	-1.3	-0.4	-0.3	-0.5	-0.8	-1.1	-1.4
Alzheimer’s Disease (including proxy)	0.8	1.2	5.2	0.6	1.0	0.4	2.3	0.0	-0.3	1.4	1.3	-0.4	1.7	-0.1
Systolic Blood Pressure	0.8	4.2	13.8	-0.3	-2.5	-2.3	-1.7	-1.9	-3.7	-2.3	-1.9	-0.9	-1.3	-1.6
Forced vital capacity (FVC)	0.8	3.0	8.9	0.5	0.8	2.5	0.6	2.5	0.7	1.6	1.2	2.0	1.4	3.0
Mouth/teeth dental problems	0.8	1.2	3.4	-1.8	-1.3	-0.0	-1.4	-0.9	-0.5	-1.3	-1.2	-0.6	-1.2	-0.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	5.2	0.3	1.3	0.2	-0.6	1.1	0.7	1.1	0.6	2.3	-0.4	-0.5
Impedance of arm (right)	0.8	3.6	14.3	-3.8	1.7	-0.0	-3.8	-0.9	1.1	-0.7	-1.8	-0.1	1.6	-0.3
Time employed in main current job	0.8	0.9	2.7	-0.2	-0.6	-1.3	0.4	-1.1	-0.9	-0.0	-0.8	0.2	-1.4	-1.6
Impedance of arm (left)	0.8	3.9	16.6	-4.1	1.5	0.2	-4.0	-0.9	1.2	-0.6	-2.0	-0.2	1.2	0.1
Length of working week for main job	0.8	0.8	2.8	-0.9	1.2	0.2	-0.5	0.8	1.5	0.5	0.7	0.7	-0.2	-1.7
Mouth/teeth dental problems: Loose teeth	0.8	1.0	4.7	2.2	0.2	-0.3	0.5	0.8	-0.0	0.4	1.1	0.9	0.9	1.4
Heart disease (mother)	0.8	0.9	3.2	1.8	0.2	1.0	0.8	0.9	0.5	1.2	0.6	0.4	-1.1	1.2
Friendships satisfaction	0.8	1.0	2.5	-1.2	-1.6	-0.5	-0.4	-1.0	-0.5	-1.4	-1.1	-1.2	0.5	-0.6
Hearing aid user	0.8	0.9	2.1	1.0	0.3	1.1	0.9	1.5	0.3	0.5	1.1	1.3	-0.2	1.2
Financial situation satisfaction	0.8	1.0	3.1	-0.4	1.2	1.3	-0.2	1.2	1.3	0.7	0.9	0.5	1.8	0.7
Commuting to job workplace: Public transport	0.8	0.9	3.1	-1.6	0.3	0.0	-1.8	0.2	1.2	-1.0	-0.6	-0.4	-0.8	-0.6
Number of operations (self-reported)	0.8	1.2	3.9	2.0	-1.7	0.2	-0.7	-0.0	-1.2	-1.5	-0.1	-1.0	0.3	1.0
Diastolic blood pressure, automated reading	0.8	2.5	7.8	2.5	-0.8	-1.4	1.9	-1.2	-2.8	-0.7	-0.1	-2.3	0.3	-0.2
Vascular/heart problems diagnosed by doctor	0.8	2.1	4.2	-0.2	1.3	1.7	1.0	1.2	1.4	2.0	1.3	1.6	1.8	1.4
Cholesterol lowering medication	0.8	1.2	3.7	0.2	-1.1	-1.3	-0.1	-1.4	-1.9	-1.0	-1.3	-1.3	-0.4	0.5
Supplements: Calcium	0.8	0.8	2.2	-1.0	-0.9	0.2	-1.0	-0.9	-1.2	-1.5	-0.8	-0.7	-0.7	-0.3
Alcohol drinker status: Previous	0.8	0.9	2.7	1.3	0.7	0.8	0.6	1.3	0.7	0.3	1.1	1.6	0.1	0.3
Intelligence (Savage-Jansen 2018)	0.7	2.0	11.2	-3.4	-0.6	-0.7	-1.9	-0.9	-0.9	-1.1	-1.7	-0.1	0.7	-0.5
Reaction Time	0.7	1.2	5.2	1.0	-0.9	2.0	0.5	1.1	1.0	0.5	0.1	-0.3	-0.2	2.3
Verbal and Numeric Reasoning (VNR)	0.7	1.8	10.4	-3.2	-0.7	-0.5	-0.9	-0.8	-1.3	-1.2	-1.5	-0.8	0.8	-0.2
Body Mass Index (BMI) (2010)	0.7	0.9	2.7	-0.7	0.3	-1.0	-0.2	-1.2	-0.0	-0.7	-0.5	-1.3	-1.4	-1.6
Coronary Artery Disease (CAD)	0.7	0.8	2.0	0.4	-1.1	-1.4	0.2	-0.6	-0.6	-0.6	-0.9	-0.5	-1.4	-1.3
Neuroticism (2016)	0.7	1.1	5.0	-1.1	2.0	0.1	0.0	-0.1	2.2	0.9	0.5	-0.1	-0.4	0.4
Chronotype (morning person)	0.7	1.6	3.1	1.2	1.6	1.5	0.3	1.6	0.1	0.5	1.4	0.9	1.8	1.6
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.8	-0.8	1.0	-1.1	-1.7	-0.9	-0.4	-1.1	-0.7	-0.7	-1.3	0.0
Pack years adult smoking proportion	0.7	1.1	4.0	0.2	1.8	-0.5	2.0	-1.1	-0.0	0.7	-0.7	-1.4	0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	5.1	1.4	0.6	1.0	1.5	1.4	0.9	0.7	2.3	0.3	1.3	-1.4
Waist circumference	0.7	2.5	9.9	-0.6	1.1	-3.1	0.6	-2.0	-1.0	-0.6	0.0	-2.0	0.0	-2.5
Past tobacco smoking	0.7	1.4	4.5	-1.4	-1.5	0.3	-2.1	-1.0	-0.7	-1.5	-0.6	-0.6	-0.9	-0.8
Exposure to tobacco smoke at home	0.7	0.7	2.9	0.4	1.6	-0.3	-0.3	0.6	0.6	0.2	1.7	0.3	0.8	-0.9
Tense / ‘highly strung’	0.7	1.2	4.0	0.5	0.8	0.7	0.7	1.2	0.7	1.4	1.1	1.0	1.1	2.0
Glaucoma (self-reported)	0.7	0.8	2.3	-0.0	-0.9	-1.0	-0.3	-1.3	-1.5	0.0	-0.8	-0.1	-1.0	1.3
Shortness of breath walking on level ground	0.7	0.8	3.5	0.2	-0.1	-0.6	-0.3	-1.2	-1.9	-0.4	-0.6	-1.2	-0.3	1.2
Commuting to job workplace: Car/motor vehicle	0.7	0.9	3.9	0.3	2.0	0.6	1.2	0.5	0.9	0.6	1.0	0.1	0.2	-1.1
Loneliness, isolation	0.7	1.0	3.6	-0.6	1.9	0.9	-0.9	0.7	1.9	0.2	0.5	-0.5	0.5	0.7
Medication for cholesterol	0.7	1.1	2.6	-0.5	1.2	0.6	1.4	0.8	1.1	1.6	0.6	1.1	1.1	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	3.3	1.0	0.5	1.8	0.1	0.9	0.6	-0.2	0.4	-0.4	0.8	1.7
Mineral and other dietary supplements	0.7	0.9	2.7	-1.1	-0.8	-1.3	0.1	-1.1	-1.3	-0.2	-1.6	-0.8	0.2	0.3
Supplements: Fish oil (including cod liver oil)	0.7	1.0	3.3	1.1	0.6	1.0	-0.2	1.4	1.2	0.5	1.8	1.1	-0.1	0.1
Medication: Bendroflumethiazide	0.7	1.0	4.5	0.4	-2.1	-0.6	-0.2	-0.7	-1.2	-1.3	-0.5	-0.8	-0.8	-0.7
Medication: Paracetamol	0.7	1.1	2.5	1.6	0.3	1.0	1.0	1.0	1.2	0.7	1.5	1.2	0.2	-0.9
Pack years of smoking	0.7	1.0	2.8	-0.2	1.5	-0.9	1.7	-1.4	-0.1	0.4	-1.0	-1.4	0.2	-0.7
Impedance of whole body	0.7	3.4	15.7	-4.0	1.3	-0.3	-3.3	-1.3	0.5	-0.8	-2.3	-0.1	0.2	-0.7
Depressed Affect (Nagel 2018)	0.6	1.3	8.2	-0.2	2.9	0.1	0.2	0.4	1.6	0.9	0.8	-0.3	1.4	-0.1
BMI	0.6	3.2	10.2	2.0	1.4	-3.2	2.7	-1.5	-1.1	-0.1	0.7	-1.8	-1.2	-1.9
Supplements: Zinc	0.6	0.7	1.7	0.9	-0.0	1.3	0.5	0.9	-0.5	0.4	0.3	1.1	-0.8	1.3
Heart attack	0.6	0.7	3.1	0.8	1.8	0.2	1.0	0.2	0.2	0.8	1.4	0.4	-0.0	0.1
Fluid intelligence score	0.6	1.2	7.9	-2.8	-0.3	-0.5	-1.2	-0.6	-0.6	-1.0	-1.1	-0.3	-0.1	-0.1
Illnesses of siblings	0.6	0.8	4.8	-0.9	0.1	0.5	0.4	-0.4	-0.5	0.6	-0.2	-0.4	2.2	1.4
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	6.1	0.9	1.0	-1.0	-0.2	-0.5	-0.9	-0.4	-0.6	-0.8	-2.5	-0.0
Blood clot in the leg (DVT)	0.6	0.8	5.2	0.6	-2.3	-0.6	-0.3	-0.2	-1.4	-0.2	-0.4	-0.3	0.5	0.1
Gout (self-reported)	0.6	0.9	5.7	-0.7	-0.1	-0.9	-1.2	-0.4	0.5	-0.9	-0.3	-0.2	-2.4	-0.4
Hypothyroidism/myxoedema (self-reported)	0.6	1.3	2.7	1.0	-1.4	-0.4	-1.1	-0.4	-1.3	-1.5	-0.6	-1.0	1.3	-1.6
High blood pressure (siblings)	0.6	0.8	3.3	-0.3	-0.8	-0.1	-1.8	0.4	0.2	-0.8	0.1	0.8	-1.5	-1.1
Wheeze or whistling in the chest in last year	0.6	1.1	4.7	1.1	2.2	-0.3	1.4	0.5	0.9	0.6	0.8	0.3	-0.2	-1.2
Medication: Allopurinol	0.6	0.8	5.3	-0.2	1.0	-0.6	-0.8	-0.1	0.8	0.1	0.5	0.3	-2.3	-0.6
Medication: Omeprazole	0.6	0.7	2.2	1.5	-1.4	-0.0	0.7	0.2	-1.1	-0.2	-0.7	0.2	0.0	1.1
Illnesses of siblings: Diabetes	0.6	0.7	3.7	0.4	-0.2	-0.6	-0.3	0.1	-0.1	-0.7	-0.4	-0.8	-1.4	-1.9
Commuting to job workplace: Walk	0.6	0.7	1.6	-0.6	-0.8	-0.6	-0.2	-1.1	-0.3	-1.2	-0.3	-1.3	0.8	-1.0
Back pain experienced in last month	0.6	0.9	2.7	0.3	-0.7	0.2	0.4	1.6	0.6	0.9	1.5	1.1	1.6	-0.0
Breast cancer (self-reported)	0.6	0.8	2.4	0.0	-0.0	-0.5	-1.4	-0.4	0.9	-1.3	-0.5	-0.9	-1.6	0.3
Number of self-reported non-cancer illnesses	0.6	1.0	3.0	0.4	-0.6	-0.5	-1.5	-0.0	-0.4	-1.7	-0.2	-0.9	-1.1	-1.6
High cholesterol (Self-reported)	0.6	1.0	3.0	-0.7	-1.7	-1.3	0.1	-0.9	-1.6	-0.6	-1.3	-0.4	-0.2	-0.4
Alzheimer’s Disease (in mother)	0.5	0.6	2.0	0.2	1.1	0.2	1.0	-0.1	0.6	1.0	1.4	-0.3	0.8	-0.2
Major Depression (MDD)	0.5	0.6	1.3	-1.0	0.8	-0.7	-0.5	-0.5	0.5	-0.6	0.5	-0.8	1.1	-1.1
Bipolar Disorder (2011)	0.5	0.5	1.4	-0.0	-1.2	-0.6	0.7	-0.8	-1.2	-0.1	-1.0	-0.2	-0.1	0.0
Crohns Disease (2012)	0.5	0.8	3.7	-0.8	0.1	0.5	-0.6	-0.2	1.4	0.2	-0.9	0.2	-1.9	0.8
HbA1C	0.5	0.5	1.9	-0.8	0.9	-0.5	-0.4	-0.5	0.7	-0.6	-0.1	-0.5	-0.7	-1.4
Triglycerides	0.5	0.7	2.7	-0.2	1.6	0.5	1.0	0.7	1.6	0.7	0.6	0.5	-0.3	-0.1
Tanning	0.5	6.1	32.7	3.7	0.4	0.2	5.7	0.1	-1.4	1.6	0.9	-1.2	2.5	2.7
Number of treatments/medications taken	0.5	0.9	3.3	0.1	-1.8	-0.8	-1.4	-0.6	-0.4	-1.4	-0.5	-0.3	-0.3	-0.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.6	1.3	-0.5	0.7	-0.6	0.3	-1.2	-0.7	-0.2	-0.5	0.2	1.2
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.2	1.5	0.4	0.8	0.7	0.5	1.0	0.8	0.5	-0.1	0.8	1.0
Medication: Metformin	0.5	0.8	1.8	0.2	0.2	-1.3	-0.1	-1.3	-0.7	-1.3	0.1	-1.0	0.4	-1.2
Diabetes (mother)	0.5	0.6	2.0	0.9	-0.3	-0.7	-0.7	-0.4	-1.4	-1.0	0.8	-0.1	-1.0	-0.2
Trunk fat percentage	0.5	1.8	8.9	-0.5	3.0	-2.1	0.5	-1.1	0.7	0.3	0.3	-1.5	0.3	-1.6
Hayfever, allergic rhinitis or eczema	0.5	1.1	6.6	-1.6	-0.2	0.1	-2.6	-0.2	1.1	-0.5	-1.1	0.1	-0.4	-0.0
Had menopause	0.5	0.6	1.6	-0.6	-0.4	-0.8	-0.5	-1.1	0.8	-0.8	-0.9	-1.2	0.0	-0.9
Medication: Lansoprazole	0.5	0.6	1.9	1.3	-0.3	0.2	0.3	0.6	0.2	0.0	0.7	1.1	-1.4	0.7
Headache pain in last month	0.5	0.9	2.6	-0.9	0.4	0.5	-1.0	1.0	1.5	1.2	-0.3	0.3	-1.6	-0.4
Birth weight	0.5	1.1	4.2	0.4	0.7	0.4	1.8	0.8	0.2	1.5	-0.4	0.5	-0.2	2.1
Body fat percentage	0.5	1.9	7.0	-0.3	2.6	-2.5	0.5	-1.3	0.4	0.1	0.3	-1.5	0.0	-1.9
Number of full brothers	0.5	0.6	2.2	0.7	-0.3	-0.0	0.1	0.9	0.8	0.5	0.8	0.6	-1.5	-0.9
Medication: Blood pressure	0.5	0.8	2.7	-0.4	-1.2	-1.2	-0.2	-0.6	-1.6	-1.0	-0.7	-0.4	0.1	-1.2
Medication: Seretide 50 evohaler	0.5	0.6	2.5	-0.7	-0.7	-0.6	-1.6	-0.3	-0.5	-0.5	-0.8	1.1	-0.1	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.9	1.4	0.8	0.4	1.3	0.5	0.5	0.6	0.7	0.7	0.7	-0.0
Illnesses of father: Heart disease	0.5	0.6	4.6	-0.1	0.1	0.2	0.5	-0.0	1.1	0.3	-0.4	0.5	-2.2	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	3.5	-0.4	1.9	0.8	-0.0	0.8	0.8	1.0	0.1	-0.2	1.8	0.7
Mood swings	0.5	0.9	5.2	-1.1	2.3	-0.8	0.7	-0.7	0.3	0.7	-0.3	-0.8	-0.0	0.6
Qualifications: nursing, teaching	0.5	0.7	3.9	0.4	0.7	0.6	-0.4	0.7	-0.2	-0.1	1.5	0.5	2.0	0.2
Illnesses of father: None of the above (group 1)	0.5	0.6	1.8	-1.3	0.6	-1.0	-1.3	-0.7	-0.4	-0.5	-0.3	-0.3	-0.1	-0.2
Tinnitus: Yes, now most or all of the time	0.5	0.5	1.7	-1.2	0.4	-0.1	-0.6	0.3	1.0	-0.3	-0.2	0.5	-0.8	-1.3
Leg fat percentage (left)	0.5	1.7	4.6	1.1	2.2	-2.1	1.5	-0.5	-0.2	0.5	1.4	-0.5	-0.4	-1.8
Irritability	0.5	0.8	2.5	0.1	0.5	-0.7	0.5	-0.7	-0.4	-0.1	-0.4	-1.6	1.5	1.3
Ever depressed for a whole week	0.5	0.7	1.4	-0.8	0.8	-1.0	-0.3	-1.2	1.1	-0.8	-0.7	-0.6	-0.9	-0.1
Pain experienced in last month	0.5	0.9	2.7	-1.6	0.8	-0.1	-0.0	-1.6	-0.0	0.0	-1.2	0.0	-0.7	1.2
Heart attack/myocardial infarction (self-reported)	0.5	0.7	3.0	0.9	1.7	0.3	1.0	0.3	0.2	0.8	1.4	0.3	-0.1	0.3
Alzheimer’s Disease (in father)	0.4	0.4	1.7	-0.2	0.0	0.5	1.2	0.1	-0.6	0.4	0.3	-0.4	1.3	-0.4
Crohns Disease (2017)	0.4	1.0	3.6	-1.4	1.0	0.2	-1.1	-0.4	1.4	0.1	-0.7	-0.1	-1.9	-0.2
Schizophrenia (2014)	0.4	0.8	3.3	0.3	-1.6	-0.5	-0.7	-0.5	0.3	-0.5	-1.3	-0.1	-1.8	-0.4
Ulcerative Colitis	0.4	0.6	1.5	-0.4	-0.6	0.4	0.4	1.1	0.6	0.9	0.5	1.2	0.4	-1.1
Blood Platelet Count	0.4	4.9	26.6	-3.8	1.2	0.4	-5.2	-0.6	1.7	-2.3	-0.1	-0.7	0.3	-1.6
Hypothyroidism (self reported)	0.4	0.8	1.7	1.1	-0.4	-0.5	-0.7	-0.9	-1.0	-1.0	-0.9	-1.1	0.7	-1.3
Respiratory disease	0.4	1.0	3.5	1.3	1.9	0.5	-0.0	1.2	0.7	1.2	0.7	1.0	0.2	0.1
Average weekly fortified wine intake	0.4	0.5	1.1	0.5	0.9	1.0	0.9	0.9	0.4	0.4	0.5	1.0	0.4	-0.1
Taking other prescription medications	0.4	0.5	1.3	1.0	-0.9	-0.6	-1.2	-0.4	-0.3	-1.0	-0.8	-0.8	-0.3	0.2
Qualifications: CSEs or equivalent	0.4	0.5	1.2	-0.6	0.8	-0.0	0.9	0.5	-0.0	0.6	0.4	1.1	0.6	-1.1
Stomach or abdominal pain in last month	0.4	0.5	1.5	1.1	-1.2	-0.1	-1.1	0.5	-0.1	-0.0	0.6	0.5	0.5	-0.1
Body mass index (BMI)	0.4	1.7	4.9	2.1	1.3	-1.5	2.2	-0.2	-0.1	0.5	1.5	-0.9	0.1	-1.2
Trunk fat mass	0.4	1.8	9.1	0.1	3.0	-1.9	1.1	-0.7	0.7	0.5	1.0	-1.2	0.4	-1.5
Nervous feelings	0.4	0.7	3.7	-0.9	0.8	-0.5	-1.9	-0.7	-0.5	-0.5	-0.2	0.3	-0.4	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.9	1.1	1.2	0.6	-0.1	0.7	0.4	0.1	1.4	-0.1	-0.2	0.9
Arm fat percentage (right)	0.4	1.6	8.2	0.2	2.9	-2.0	0.5	-0.8	0.8	0.2	0.9	-0.9	0.8	-1.4
Hair/balding pattern: Pattern 3	0.4	0.6	1.5	1.2	-1.1	0.6	1.2	0.2	-0.8	-0.1	-0.4	-0.6	0.0	0.7
Happiness	0.4	0.4	1.0	-0.6	-0.9	-1.0	-0.4	-0.9	-0.5	-0.9	-0.3	-0.5	0.7	-0.1
Arm fat mass (right)	0.4	1.6	6.8	0.6	2.6	-1.9	1.3	-0.6	0.5	0.4	1.1	-1.0	0.6	-1.4
Hair/balding pattern: Pattern 4	0.4	1.0	3.1	1.0	-0.0	-0.5	1.0	-0.7	-1.7	-0.9	-0.2	-1.1	0.0	-1.8
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.3	0.9	0.2	-1.2	0.2	-0.2	0.5	0.2	0.1	-0.1	-1.5	-0.9
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.6	0.5	0.9	-0.4	1.0	-0.1	0.7	-0.1	0.3	-0.6	0.4	-1.3
Leg fat percentage (right)	0.4	1.5	4.7	1.0	2.2	-2.1	1.5	-0.5	0.1	0.4	1.2	-0.4	-0.6	-1.5
Worry too long after embarrassment	0.4	0.6	2.2	0.1	0.2	-0.3	-1.1	-0.3	-0.8	-1.5	-0.4	-1.4	-0.4	0.8
Mean time to correctly identify matches	0.4	0.8	3.1	0.5	-1.4	0.9	-0.8	-0.2	0.6	-0.8	-0.5	-0.8	-0.3	1.8
Whole body fat mass	0.4	1.7	6.4	0.3	2.5	-2.2	1.2	-0.9	0.3	0.3	0.9	-1.3	0.2	-1.6
Leg fat mass (right)	0.4	1.6	4.4	1.0	2.1	-2.1	1.7	-0.6	0.1	0.3	1.1	-0.8	-0.4	-1.5
Alcohol intake frequency.	0.4	0.9	3.8	-0.1	-0.2	0.2	-1.2	0.2	0.1	-1.3	0.7	0.2	-1.4	-2.0
Number of full sisters	0.4	0.4	3.5	1.9	-0.6	-0.2	0.7	-0.0	-0.2	0.2	0.1	0.3	-0.3	0.4
Suffer from ‘nerves’	0.4	0.6	3.8	-1.0	0.2	-0.6	-1.9	-0.5	-0.2	-0.9	0.1	-0.2	-0.1	0.4
Family relationship satisfaction	0.4	0.5	3.3	-1.0	-0.7	0.1	-0.1	-0.2	-0.1	-0.5	0.2	-0.1	1.8	0.5
Arm fat percentage (left)	0.4	1.5	7.0	-0.0	2.6	-2.1	0.4	-1.0	0.7	0.2	0.7	-1.1	0.5	-1.4
Eye problems/disorders: Cataract	0.4	0.4	1.5	-0.3	-0.3	0.4	-1.2	0.2	0.6	-0.7	-0.5	-0.0	-0.7	1.1
Osteoarthritis (self-reported)	0.4	0.6	2.0	0.1	-0.6	-0.9	0.6	-0.5	-0.9	-0.9	-0.2	-1.4	-0.4	-0.9
Mother’s age at death	0.4	0.4	1.2	0.4	0.5	0.9	-0.9	0.6	0.0	0.0	0.4	0.9	-0.5	1.1
Ever smoked	0.4	0.7	3.8	0.7	1.0	-1.0	1.9	-0.4	-0.4	0.7	-0.7	-0.6	-0.1	0.2
Risk taking	0.4	0.6	3.6	0.7	0.3	0.4	1.0	0.4	1.9	0.2	0.0	-0.2	-1.1	-0.0
Leg fat mass (left)	0.4	1.7	4.5	1.1	2.1	-2.0	1.8	-0.6	0.1	0.4	1.3	-0.8	-0.3	-1.6
Neuroticism (Nagel 2018)	0.3	0.7	4.1	-0.3	2.0	-0.4	-0.4	-0.1	1.1	0.1	0.1	-0.9	1.1	0.1
Irritable Bowel Disease (IBD)	0.3	0.6	1.9	-1.4	-0.1	-0.2	-0.4	-0.3	0.7	0.1	-0.7	-0.1	-1.4	-1.4
Ulcerative Colitis (UC)	0.3	0.5	2.7	-1.0	-0.8	-0.7	0.3	-0.4	-0.4	0.1	-0.7	-0.3	0.0	-1.6
Breast Cancer	0.3	0.7	3.1	0.1	0.1	-0.2	1.8	-0.9	0.4	0.0	-0.3	-1.4	-0.9	-0.2
Ovarian Cancer	0.3	0.4	1.2	-0.2	1.1	0.3	-0.6	0.5	1.0	0.7	-0.0	0.7	0.1	0.7
Age at First Birth	0.3	0.4	0.9	-1.0	-0.9	0.6	-0.8	-0.3	-0.5	-0.1	-0.9	-0.0	-0.6	0.5
Fasting Glucose	0.3	0.4	1.2	-0.4	-1.1	0.1	0.4	-0.2	-0.1	-0.6	-0.2	-1.1	-0.3	-1.1
Primary Biliary Cirrhosis	0.3	0.4	1.8	-0.3	-1.3	0.6	-0.7	0.4	-0.6	-0.9	-0.1	-0.2	0.5	0.1
Heel T-Score	0.3	2.7	6.6	0.6	0.7	2.1	2.0	2.5	2.6	1.7	1.1	1.7	1.2	-0.2
Allergy or Eczema	0.3	0.8	5.1	-1.2	0.3	0.7	-2.3	0.3	1.0	-0.3	-0.6	0.5	-0.0	0.2
Neuroticism	0.3	0.8	2.6	0.1	1.6	0.4	-0.1	1.3	0.7	0.9	0.9	0.6	0.9	0.9
Hand grip strength (left)	0.3	0.7	2.1	1.1	-0.3	1.2	1.0	0.7	-0.2	0.9	0.9	0.4	0.1	1.4
Hearing difficulty/problems: Yes	0.3	0.4	1.7	1.3	0.4	-0.5	0.6	0.7	0.6	1.1	0.2	0.4	0.0	-0.2
Medication for hormone replacement therapy	0.3	0.4	1.7	1.3	-0.6	0.0	0.6	-0.4	-0.5	-0.0	0.2	-0.8	0.6	-0.4
Vitamin and mineral supplements	0.3	0.5	3.2	-1.8	-0.3	-0.6	0.4	-0.3	0.0	-0.1	-1.0	-0.4	0.2	-0.4
Impedance of leg (right)	0.3	1.6	8.4	-2.9	1.0	-0.4	-1.6	-0.9	0.2	-0.4	-1.8	0.4	-0.4	-0.9
Hand grip strength (right)	0.3	0.8	2.8	-0.2	0.8	1.7	-0.1	0.9	0.4	0.9	0.7	1.1	0.4	1.3
Fed-up feelings	0.3	0.6	2.4	0.5	1.5	-0.3	1.3	-0.1	0.5	0.9	0.2	-0.6	0.9	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	-0.4	0.4	-0.9	-0.7	-0.7	-0.4	-0.6	-0.6	-0.6	-0.6	0.7
Medication: Atenolol	0.3	0.4	2.0	0.5	0.4	0.3	1.0	0.2	-0.3	0.1	0.4	0.1	1.4	0.3
Impedance of leg (left)	0.3	1.5	8.0	-2.8	0.9	-0.3	-1.6	-0.8	-0.2	-0.3	-1.6	0.3	-0.2	-1.1
Number of incorrect matches in round	0.3	0.6	2.0	1.1	-0.3	0.8	0.4	0.7	0.7	0.3	1.4	0.7	0.4	0.4
Allergy	0.3	0.7	4.5	0.4	0.1	-0.2	2.1	0.0	-1.1	0.3	1.0	0.1	0.4	-0.2
Weight	0.3	1.4	3.7	1.3	1.8	-1.4	1.9	-0.1	0.0	0.5	1.5	-0.9	0.1	-1.1
Asthma	0.3	0.6	2.5	0.5	1.6	0.4	-0.6	0.5	1.6	0.1	0.5	0.4	0.4	-0.5
Depression (self-reported)	0.3	0.3	0.9	-0.1	-0.2	-1.0	-0.4	-0.7	-0.6	-0.8	-0.0	-0.8	-0.5	-0.2
Illnesses of mother	0.3	0.3	1.0	0.0	-0.1	1.0	0.4	0.7	0.5	0.5	0.6	1.0	0.5	0.0
Exposure to tobacco smoke outside home	0.3	0.4	1.8	0.1	1.4	0.9	0.7	0.4	0.2	0.9	0.6	0.3	-0.1	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.8	0.3	0.1	-0.4	-0.2	0.2	0.8	0.1	-0.1	1.1	-1.4	0.2
Emphysema/chronic bronchitis	0.3	0.3	1.3	0.1	1.1	0.4	-0.2	0.7	0.6	0.7	0.2	0.3	0.9	0.2
Migraine (self-reported)	0.3	0.4	1.3	0.5	-0.8	0.1	1.2	0.5	-1.0	0.6	-0.0	-0.2	-0.4	0.3
Smoking status: Previous	0.3	0.4	1.4	0.9	0.5	-0.5	1.2	0.5	0.9	0.6	0.3	0.3	0.3	0.6
Long-standing illness, disability or infirmity	0.3	0.5	1.8	1.4	-0.1	0.3	-0.4	0.5	0.3	-1.0	0.6	-0.3	0.8	-0.6
Asthma (self-reported)	0.3	0.7	2.6	0.3	1.6	0.6	-0.6	0.7	1.6	0.2	0.5	0.6	0.1	-0.5
Medication: Aspirin	0.3	0.3	1.3	-0.2	-0.2	-0.3	-0.8	-0.7	-0.7	-0.6	-0.5	-1.1	-0.3	-0.4
Arm fat mass (left)	0.3	1.4	4.5	0.9	2.1	-1.8	1.4	-0.5	0.4	0.3	1.1	-1.1	0.3	-1.3
Average weekly champagne plus white wine intake	0.3	0.4	1.1	-0.3	0.9	-0.6	-1.0	0.2	-0.1	-0.2	-0.0	-0.0	1.0	-0.7
Ever taken oral contraceptive pill	0.3	0.3	1.0	-0.8	0.3	-0.2	0.9	-0.1	-0.5	0.8	-0.0	0.4	1.0	0.2
Illnesses of father: High blood pressure	0.3	0.3	0.8	-0.1	-0.8	-0.9	-0.8	-0.4	-0.6	-0.1	-0.6	-0.0	-0.3	-0.7
Alcohol drinker status: Never	0.3	0.4	1.9	0.3	-0.1	0.1	-0.7	0.4	0.5	-0.1	0.8	0.2	-0.5	-1.4
Unable to work because of sickness or disability	0.3	0.4	1.1	0.9	0.7	-0.1	1.0	0.5	-0.0	0.4	0.4	0.3	1.0	0.4
Bipolar Disorder or Schizophrenia	0.2	0.4	1.0	0.8	-0.7	0.3	-0.1	0.7	0.6	0.7	0.0	1.0	-0.8	0.1
Schizophrenia (2018)	0.2	0.5	1.7	1.1	-0.5	0.0	-0.4	0.4	0.6	0.9	-0.1	0.7	-1.3	0.5
Worry (Nagel 2018)	0.2	0.4	1.8	-1.0	0.8	-0.6	-1.3	-0.4	0.2	-0.3	-0.2	-0.1	-0.1	0.1
Prostate Cancer	0.2	0.2	1.0	0.3	0.4	0.3	-1.0	0.4	0.4	-0.5	0.3	-0.2	-0.5	0.2
LDL Cholesterol	0.2	0.3	1.1	-0.0	-0.4	-0.8	0.6	-0.1	-0.3	0.2	-0.2	-0.2	1.0	-0.7
Blood Red Count	0.2	2.0	6.5	-1.0	2.1	-0.2	-2.2	-0.0	2.5	0.5	0.9	1.2	-0.7	-1.5
Lung FEV1/FVC ratio	0.2	1.0	2.2	-1.5	1.2	-0.1	1.4	0.4	1.5	1.3	0.1	0.6	-0.6	-0.9
Severe depression (siblings)	0.2	0.2	0.5	0.0	0.7	0.6	-0.2	0.0	0.4	0.5	0.1	-0.6	0.2	0.4
Multivitamins +/- minerals	0.2	0.3	1.2	1.1	0.4	0.0	-0.4	-0.2	-0.2	0.0	0.4	0.4	-0.1	1.0
Leg predicted mass (left)	0.2	0.8	2.2	1.2	1.3	-0.6	1.5	0.3	0.5	0.5	1.4	-0.7	0.0	-0.1
Medication: Ramipril	0.2	0.2	1.2	-0.1	-0.8	-0.3	-0.1	0.1	-1.1	0.2	-0.3	0.7	-0.1	0.0
Trunk fat-free mass	0.2	1.0	3.9	1.6	0.5	-0.3	2.0	0.8	-0.3	0.6	1.7	0.2	-0.0	0.0
Hip circumference	0.2	0.9	2.6	1.6	0.7	-1.1	1.6	0.2	-0.4	0.4	1.2	-0.7	-0.1	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	0.4	0.3	0.2	0.5	-0.5	-0.3	0.3	-0.7	-0.5	0.3	0.6
Medication: Cholesterol lowering	0.2	0.2	1.2	0.5	-0.1	-0.5	0.9	0.1	-1.1	0.1	0.2	0.2	-0.0	-0.1
Trunk predicted mass	0.2	0.9	3.7	1.6	0.4	-0.4	1.9	0.8	-0.4	0.5	1.7	0.2	-0.1	0.0
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.6	0.3	0.6	0.7	-0.4	0.5	1.3	0.2	0.2	0.3	0.2	0.4
Arm fat-free mass (right)	0.2	1.1	5.6	1.8	0.3	-0.9	2.4	0.3	-0.5	0.5	1.3	-0.4	-0.8	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.1	1.0	-0.3	0.5	0.1	0.6	-0.2	0.1	0.1	-0.1	0.2	1.0
Age at first live birth	0.2	0.4	1.5	-1.2	-0.1	1.0	-0.5	0.1	0.3	0.0	-0.4	-0.5	0.8	0.2
Health satisfaction	0.2	0.2	0.7	-0.4	0.6	-0.1	0.4	-0.3	0.8	0.1	0.5	-0.2	0.8	-0.0
Qualifications: College or University degree	0.2	0.7	2.7	-0.3	0.4	1.1	-1.1	0.4	0.2	1.0	0.8	0.1	1.6	0.8
Neck or shoulder pain in last month	0.2	0.3	0.8	0.0	0.3	-0.6	-0.8	0.1	-0.9	-0.3	0.6	-0.2	0.4	-0.5
Angina (self-reported)	0.2	0.2	0.5	-0.6	0.7	-0.6	-0.4	-0.1	0.4	-0.5	-0.2	-0.1	-0.5	-0.7
Arm predicted mass (right)	0.2	0.9	3.3	1.3	0.2	-1.2	1.8	0.1	-0.4	0.1	1.1	-0.5	-1.3	-0.6
Age at last live birth	0.2	0.2	0.7	-0.4	0.4	0.5	-0.1	-0.3	0.5	0.1	-0.7	-0.9	0.7	-0.0
Medication: Aspirin	0.2	0.3	1.0	-0.2	0.2	-0.1	-0.8	-0.5	-0.8	-0.4	-0.1	-1.0	0.3	-0.6
Whole body fat-free mass	0.2	0.9	3.6	1.6	0.8	-0.5	1.9	0.6	0.0	0.5	1.6	-0.2	-0.2	-0.1
Leg fat-free mass (right)	0.2	0.9	2.8	1.5	1.1	-0.3	1.7	0.5	0.2	0.7	1.6	-0.6	0.4	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.1	0.8	-1.0	-0.1	-0.6	0.1	-0.6	-0.1	-0.4	0.4	0.3	0.6
Whole body water mass	0.2	1.0	4.0	1.6	0.7	-0.5	2.0	0.7	-0.0	0.6	1.6	-0.1	-0.1	0.0
Leg predicted mass (right)	0.2	0.9	2.7	1.5	1.1	-0.4	1.6	0.5	0.2	0.6	1.6	-0.6	0.4	-0.1
Basal metabolic rate	0.2	1.1	4.1	1.6	1.1	-0.7	2.0	0.4	-0.0	0.6	1.6	-0.4	-0.1	-0.4
Arm fat-free mass (left)	0.2	1.2	4.8	1.8	0.5	-1.1	2.2	0.2	-0.6	0.4	1.3	-0.2	-0.8	-0.5
Average weekly beer plus cider intake	0.2	0.4	2.6	0.0	1.6	0.5	0.3	0.2	0.2	0.3	-0.3	-0.4	0.6	-0.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	1.2	0.2	0.0	0.6	-0.3	0.5	0.3	-0.1	0.4	0.0	-0.0	1.1
Myopia	0.2	0.3	0.8	-0.3	0.9	-0.2	0.8	-0.4	0.7	0.4	-0.1	-0.1	-0.2	-0.9
Arm predicted mass (left)	0.2	1.2	5.7	2.0	0.4	-0.8	2.4	0.3	-0.6	0.4	1.4	-0.3	-0.7	-0.2
Bipolar Disorder (2018)	0.1	0.2	0.6	-0.1	-0.5	0.4	0.3	0.6	0.1	0.1	0.1	0.8	0.4	-0.4
Hair Pigment	0.1	3.1	7.8	-0.6	-1.6	-2.3	-0.5	-1.5	-0.7	-2.8	-1.8	-2.0	-2.2	-1.8
Angina	0.1	0.2	0.6	-0.3	0.5	-0.6	-0.2	0.0	0.3	-0.4	-0.1	-0.0	-0.5	-0.8
Leg fat-free mass (left)	0.1	0.8	2.3	1.2	1.2	-0.7	1.5	0.2	0.4	0.5	1.4	-0.7	0.0	-0.3
Sitting height	0.1	0.5	1.4	-1.1	-0.2	-0.3	-1.2	-0.2	-0.9	-1.2	-0.1	-0.8	0.2	-0.5
Neuroticism score	0.1	0.3	1.2	-0.2	1.1	-0.4	0.1	-0.0	-0.1	0.0	0.3	-0.7	0.4	0.9
Lung cancer (father)	0.1	0.1	0.4	0.5	-0.1	-0.3	0.6	0.1	0.4	-0.6	0.3	-0.2	-0.3	-0.3
Eye problems/disorders: None of the above	0.1	0.2	0.5	-0.1	-0.7	0.4	0.4	0.3	0.2	0.5	0.3	0.3	-0.2	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.5	-0.7	-0.3	-0.2	-0.2	-0.6	-0.2	-0.4	-0.4	-0.1	-0.7	-0.4
Height	0.0	0.9	2.8	-1.7	1.6	0.0	-1.0	-0.8	0.4	-0.5	-1.1	-0.3	-0.6	1.2
Standing height	0.0	0.5	2.0	-1.4	1.4	0.5	-0.1	0.5	0.4	0.3	0.2	0.1	0.5	0.4

Hub : Genes

LEPR

Models

Trait associations