TWAS hub - LEPROT

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3780	0.0460	0.0e+00	0.290	0.276	0.310	0.320	0.314	1.5e-35	1.1e-33	2.3e-38	8.3e-40	5.5e-39
2	GTEx	Brain Caudate basal ganglia	0.4360	0.0980	5.2e-05	0.409	NA	0.371	NA	0.395	6.1e-13	NA	1.3e-11	NA	1.9e-12
3	GTEx	Brain Cortex	0.2290	0.0850	5.0e-03	0.070	NA	0.003	NA	0.073	5.6e-03	NA	2.6e-01	NA	4.7e-03
4	GTEx	Skin Not Sun Exposed Suprapubic	0.1660	0.0570	1.1e-03	0.007	NA	0.045	NA	0.020	1.3e-01	NA	1.6e-03	NA	2.8e-02
5	GTEx	Whole Blood	0.3840	0.0910	4.6e-04	0.202	NA	0.150	NA	0.196	2.4e-18	NA	1.0e-13	NA	8.7e-18
6	METSIM	Adipose	0.0776	0.0290	3.5e-04	0.038	0.024	0.048	0.032	0.031	1.8e-06	1.3e-04	9.3e-08	1.1e-05	1.5e-05
7	NTR	Blood	0.0967	0.0228	2.8e-15	0.046	0.066	0.086	0.083	0.087	1.1e-14	2.5e-20	2.2e-26	1.6e-25	1.1e-26
8	ROSMAP	Brain Pre-frontal Cortex	0.2905	0.0455	0.0e+00	0.250	0.238	0.265	0.244	0.261	6.9e-32	2.8e-30	5.6e-34	4.8e-31	1.7e-33
9	YFS	Blood	0.3975	0.0395	0.0e+00	0.254	0.346	0.380	0.380	0.377	1.5e-82	1.9e-118	2.0e-133	2.7e-133	4.4e-132
10	TCGA	Breast Invasive Carcinoma	0.0160	0.0091	4.4e-03	0.010	0.008	0.002	NA	0.004	2.9e-03	7.0e-03	1.3e-01	NA	3.5e-02
11	TCGA	Colon Adenocarcinoma	0.1330	0.0550	4.0e-04	0.025	0.035	0.044	NA	0.041	1.4e-02	4.1e-03	1.4e-03	NA	2.0e-03
12	TCGA	Testicular Germ Cell Tumors	0.1650	0.0770	1.3e-03	0.132	0.087	0.098	NA	0.096	2.1e-05	5.4e-04	2.5e-04	NA	2.9e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Age when periods started (menarche)	5.4	12.8	39.9	2.6	1.6	2.3	-1.9	0.3	-2.9	-6.3	2.2	-5.8	-4.0	-4.9	-3.1
Number of children fathered	3.9	4.5	8.2	-2.2	-1.6	-2.2	1.4	-1.2	2.9	2.5	-2.1	2.4	2.2	2.4	1.7
Average weekly spirits intake	3.7	4.6	14.2	-2.4	-2.4	-3.8	2.9	-0.8	1.2	1.5	-2.5	1.5	2.3	0.9	1.4
Heel bone mineral density (BMD) T-score, automated (left)	3.7	8.4	13.0	-2.9	-2.6	-2.8	3.2	-1.4	3.5	2.7	-2.9	2.9	3.6	2.8	3.1
Basal cell carcinoma (self-reported)	3.5	4.2	9.3	2.3	1.4	1.5	-1.3	0.5	-0.9	-3.0	1.6	-3.0	-2.3	-2.7	-2.1
Comparative body size at age 10	3.3	9.2	28.1	-0.2	0.7	0.4	-0.1	3.7	0.1	4.8	0.8	5.3	3.4	4.9	3.1
Chest pain or discomfort	3.1	4.5	13.5	-2.6	-2.2	-3.7	2.2	0.4	0.8	1.5	-2.5	1.9	2.2	2.1	1.3
Heel bone mineral density (BMD) T-score, automated (right)	3.0	6.9	11.7	-2.7	-2.2	-2.6	2.6	-1.6	3.4	2.6	-2.5	2.5	3.2	2.5	2.8
Alzheimer’s Disease (in mother)	2.7	3.2	8.1	0.2	0.4	-0.7	1.6	0.6	2.0	2.4	0.1	2.7	2.2	2.2	2.8
Osteoporosis (self-reported)	2.7	3.3	12.2	0.4	-0.4	0.0	-1.1	3.5	-2.0	-1.8	-0.1	-1.6	-1.2	-2.5	-2.8
Medication: Paracetamol	2.6	4.3	7.5	-2.1	-1.4	-2.2	2.2	-0.3	2.7	2.4	-2.1	2.2	1.9	2.4	1.9
Age at first live birth	2.6	4.5	12.2	3.4	3.0	3.5	-1.6	-0.4	-0.4	-0.4	3.0	-0.3	-2.8	-0.5	-1.1
Age at last live birth	2.5	3.6	10.3	2.8	2.6	3.2	-2.0	-0.9	-1.0	-0.3	2.6	-0.6	-2.1	-0.5	-1.1
Leg pain on walking	2.5	3.1	7.5	-0.6	-0.5	-0.7	1.3	-1.1	2.2	2.7	-0.7	2.5	1.8	2.5	2.2
Medication: Co-codamol	2.4	2.8	7.6	-1.5	-1.8	-2.8	2.5	-1.0	2.2	0.4	-2.1	0.4	0.9	0.9	1.5
Ever had bowel cancer screening	2.4	2.9	4.9	2.0	1.4	1.2	-0.4	-0.1	-1.7	-2.2	1.4	-2.1	-2.2	-2.2	-1.8
Supplements: Calcium	2.4	2.7	6.1	2.4	1.3	0.8	-0.5	0.4	-1.7	-1.5	1.8	-1.3	-2.0	-2.5	-1.8
Age at First Birth	2.3	3.3	9.0	1.6	1.3	3.0	-2.7	0.7	-1.2	-1.8	1.6	-1.4	-2.0	-1.7	-1.6
Medication: Levothyroxine sodium	2.3	3.8	13.0	1.5	0.5	-0.1	1.2	1.5	-3.6	-2.2	0.6	-1.7	-1.9	-2.6	-2.8
Supplements: Zinc	2.2	2.4	6.4	1.1	1.0	0.9	-1.8	-0.3	-2.5	-0.7	1.1	-1.1	-1.2	-2.5	-2.3
Pain experienced in last month	2.2	3.7	9.2	1.9	2.3	3.0	-2.2	-1.5	-2.0	-1.2	2.8	-1.6	-1.4	-1.0	-0.5
Blood White Count	2.1	15.4	55.5	1.1	-2.8	-2.5	3.5	-0.0	-5.8	-7.2	-3.2	-7.5	-1.1	-0.6	-2.1
BMI	2.1	12.3	31.7	-1.3	-1.2	-2.4	3.5	-1.1	3.5	4.2	-1.3	4.3	5.4	3.8	5.6
Had other major operations	2.1	2.6	5.0	2.2	1.1	0.9	0.4	0.1	-1.5	-2.2	1.2	-1.8	-2.0	-2.2	-2.0
Pain all over the body in last month	2.1	2.2	4.5	-1.7	-1.1	-1.6	0.3	-0.3	1.4	2.1	-1.4	2.0	1.3	2.0	1.4
Medication: Allopurinol	2.1	2.7	9.4	-0.5	-0.7	-0.9	1.9	-1.3	2.0	1.1	-0.8	1.2	1.8	2.5	3.1
Knee pain experienced in last month	2.1	3.2	9.8	-1.3	-1.8	-2.8	3.1	0.9	1.0	1.1	-2.3	1.4	1.3	1.9	0.6
Blood Eosinophil Count	2.0	15.4	65.9	-3.6	-3.1	-2.9	8.1	0.5	-1.6	3.3	-3.6	3.4	4.5	4.3	3.4
Relative age of first facial hair	2.0	4.0	14.6	0.4	-0.8	-0.5	-0.1	-2.2	-1.7	-3.2	-0.8	-3.8	-2.4	-1.9	-2.2
Financial difficulties in last 2 years	2.0	2.7	8.1	-1.4	-1.8	-2.0	2.1	0.3	-0.1	1.2	-1.5	1.0	2.0	2.8	0.9
Average weekly champagne plus white wine intake	2.0	2.7	6.7	-2.2	-2.6	-1.7	2.5	0.0	-0.4	-0.9	-2.6	-0.9	1.6	1.1	0.1
Medication: Blood pressure	2.0	3.9	9.4	-2.6	-2.9	-3.1	2.6	0.7	-0.0	-1.4	-2.9	-0.4	1.8	0.1	1.0
Alzheimer’s Disease (including proxy)	1.9	2.8	7.8	0.7	0.8	-0.1	1.1	0.5	1.5	2.8	0.7	2.8	1.8	1.8	2.3
Body Mass Index (BMI) (2010)	1.9	2.6	5.6	-1.9	-1.8	-2.4	1.2	0.3	2.0	0.5	-1.7	0.7	2.2	1.4	1.6
Smoking Status	1.9	4.5	15.1	-1.6	-0.4	-0.1	-1.3	0.6	1.2	3.9	0.0	3.5	2.7	2.4	2.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.6	6.2	2.0	1.4	1.4	-2.1	1.9	-2.5	-1.0	1.5	-1.2	-0.6	-1.3	-1.5
Pulse wave reflection index	1.9	2.4	5.2	-1.5	-0.6	-1.2	1.3	0.1	1.6	1.8	-1.1	2.3	1.7	1.9	2.1
Medication for pain relief, constipation, heartburn	1.9	3.3	8.7	0.0	-0.3	0.6	-1.9	0.0	-2.9	-2.7	0.2	-3.0	-1.4	-1.9	-2.3
Osteoarthritis (self-reported)	1.9	2.5	6.6	-0.6	-0.4	-2.1	1.7	0.2	2.6	1.2	-0.7	2.1	1.5	2.0	1.8
Diabetes (father)	1.8	2.2	5.5	-1.5	-2.3	-2.0	0.5	0.3	-0.6	-1.9	-2.3	-1.7	1.1	-1.0	-0.6
Impedance of arm (left)	1.8	8.2	19.4	1.7	1.0	1.0	-1.7	-0.2	-4.2	-3.7	1.5	-4.4	-4.3	-2.2	-3.9
Wheeze or whistling in the chest in last year	1.8	3.2	6.3	-1.9	-1.4	-2.0	1.1	1.9	0.2	2.0	-1.6	2.5	2.4	1.7	1.4
Supplements: Fish oil (including cod liver oil)	1.8	2.3	6.8	-0.5	-0.5	-1.6	2.6	-2.0	1.4	1.6	-1.1	1.7	1.2	1.8	1.0
Birth weight	1.7	3.6	9.4	1.3	2.1	2.5	-2.4	-3.1	-1.2	0.2	2.4	-0.7	-2.3	-0.9	-1.6
Mean time to correctly identify matches	1.7	3.2	9.3	2.7	2.3	3.0	-0.2	-1.0	-1.1	-0.9	2.1	-1.5	-1.9	-1.5	-1.2
Leg fat percentage (left)	1.7	6.3	14.3	-1.8	-1.6	-2.4	2.2	-2.6	1.5	2.6	-1.9	2.3	3.8	3.0	3.4
Ever had hysterectomy (womb removed)	1.6	1.8	4.2	2.0	2.0	1.7	-1.0	0.1	-0.6	0.2	2.0	0.4	-1.4	-1.6	-0.7
Body mass index (BMI)	1.6	6.9	15.1	-1.0	-0.9	-1.8	2.6	-1.3	2.7	3.4	-1.4	3.4	3.9	3.0	3.7
Number of incorrect matches in round	1.6	2.6	5.9	2.4	2.3	2.4	-1.4	0.0	-1.3	-0.2	1.9	-0.6	-1.4	-1.4	-1.6
Falls in the last year	1.6	2.2	5.3	-1.6	-1.8	-2.3	1.4	-1.4	1.5	0.5	-2.0	0.7	1.2	1.5	0.7
Commuting to job workplace: Car/motor vehicle	1.6	1.8	5.5	-0.4	-0.2	0.0	0.6	-0.7	2.1	2.0	-0.2	2.3	1.1	1.6	1.7
Medication: Paracetamol	1.6	2.5	4.5	-1.7	-1.1	-1.5	1.4	-0.2	2.1	1.9	-1.6	1.6	1.5	1.9	1.6
Reaction Time	1.5	2.8	11.4	2.2	2.4	3.4	-1.2	-0.5	-0.5	-0.3	2.1	-0.7	-1.8	-0.9	-1.1
Neuroticism (2016)	1.5	2.1	5.4	2.3	2.1	2.3	-1.2	-1.0	0.4	0.6	1.8	-0.1	-0.7	1.7	0.6
Cardiovascular Disease	1.5	5.1	10.1	-2.4	-2.8	-2.7	2.4	-0.5	2.5	-0.0	-2.6	0.7	3.2	1.5	2.8
Hearing difficulty/problems: Yes	1.5	2.2	6.0	-1.3	-0.8	-2.5	2.3	-1.5	0.3	1.4	-0.7	1.3	1.2	2.0	1.4
Diabetes (mother)	1.5	1.9	5.5	-0.1	-0.1	-1.2	1.8	-0.9	0.8	1.4	-0.4	1.6	2.3	1.1	2.2
Heart disease (mother)	1.5	1.9	7.3	-0.5	0.2	-1.0	0.8	-2.7	2.2	1.8	-0.1	1.7	0.1	0.8	1.1
Medication for cholesterol	1.5	2.2	6.1	1.8	2.0	2.5	-2.1	0.1	-0.8	0.4	2.2	-0.1	-1.5	-0.2	-1.1
Leg fat mass (left)	1.5	6.0	14.7	-1.4	-1.2	-2.0	2.1	-1.8	2.0	2.8	-1.6	2.7	3.8	2.9	3.4
Townsend deprivation index at recruitment	1.4	1.9	4.5	1.8	2.1	1.1	-0.8	-0.8	-1.1	0.7	2.1	-0.2	-2.0	-0.8	-1.4
Illnesses of siblings	1.4	2.0	4.0	1.8	1.6	2.0	-1.0	-0.4	-0.6	-0.9	1.6	-1.5	-1.8	-1.3	-1.6
Impedance of arm (right)	1.4	6.6	19.1	0.9	0.1	0.3	-1.4	0.1	-4.4	-3.5	0.7	-4.2	-3.4	-1.7	-3.5
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	3.8	-1.6	-1.4	-1.0	1.7	-0.4	0.9	0.5	-1.8	0.8	1.4	2.0	1.5
Leg fat percentage (right)	1.4	5.2	11.5	-1.4	-1.0	-2.0	1.8	-2.5	1.4	2.5	-1.4	2.2	3.4	2.9	3.2
Neck or shoulder pain in last month	1.4	2.0	8.7	-0.2	-0.7	-2.4	2.9	0.9	0.6	0.4	-1.2	0.8	1.6	1.3	0.9
Illnesses of siblings: Diabetes	1.4	1.7	4.8	-1.5	-2.2	-1.9	1.0	0.7	-0.4	-0.0	-2.1	0.6	1.5	0.4	0.3
Long-standing illness, disability or infirmity	1.4	2.2	7.5	-1.0	-1.3	-2.1	2.7	0.8	0.0	1.0	-1.8	1.3	1.7	1.2	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	4.5	0.9	1.0	1.6	-2.1	1.1	-1.7	-0.3	0.9	-0.4	-1.4	-1.0	-1.7
Number of self-reported non-cancer illnesses	1.4	2.4	8.1	-1.6	-1.9	-2.9	2.6	0.5	-0.1	0.2	-2.1	0.9	1.3	0.8	0.4
Coronary Artery Disease (CAD)	1.3	1.6	3.1	-1.8	-1.7	-1.6	0.6	0.7	1.4	0.2	-1.7	1.0	1.4	0.8	1.1
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	5.0	1.1	1.3	1.0	-1.3	2.2	-1.8	0.1	1.0	0.4	-0.3	-0.5	-1.2
High blood pressure	1.3	3.6	7.4	-2.4	-2.7	-2.6	2.3	-0.1	1.3	-0.8	-2.7	0.3	2.1	1.1	1.7
Mouth/teeth dental problems	1.3	2.0	5.2	1.4	1.2	0.8	-1.5	-0.6	-0.3	-1.7	1.3	-1.7	-1.6	-2.3	-1.4
Exposure to tobacco smoke at home	1.3	1.5	3.6	-0.9	-1.1	-1.4	1.7	-1.9	0.7	1.2	-1.5	0.4	1.1	1.0	0.9
Loud music exposure frequency	1.3	1.4	4.3	-2.1	-1.9	-1.6	0.5	-0.6	0.4	-0.3	-1.8	-0.6	0.9	0.8	0.9
Leg fat mass (right)	1.3	5.1	12.9	-1.2	-0.9	-1.8	1.8	-1.7	1.8	2.6	-1.3	2.6	3.6	2.8	3.2
Family relationship satisfaction	1.3	1.6	2.8	1.7	1.6	1.3	-1.3	1.5	-1.2	-0.4	1.5	-0.1	-1.0	-1.6	-1.1
Impedance of whole body	1.3	6.8	18.0	0.6	0.1	0.4	-2.0	0.1	-4.0	-3.7	0.8	-4.2	-3.6	-2.0	-3.5
Bipolar Disorder (2011)	1.2	1.1	2.6	1.4	1.0	1.6	-1.2	0.0	-0.6	-0.9	1.3	-0.7	-1.4	-0.8	-0.9
Fasting Glucose	1.2	1.4	3.2	-1.8	-1.4	-0.9	-0.5	-0.7	1.3	0.6	-1.4	0.5	1.8	0.5	1.4
Happiness	1.2	1.5	4.0	1.5	1.0	1.6	-1.1	2.0	-1.4	-0.7	1.2	-0.3	-0.6	-1.3	-0.9
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	7.6	-0.2	-1.0	-1.0	1.6	1.3	-2.8	-1.2	-0.9	-1.0	-1.1	-1.8	-2.4
Hypertension (Self-reported)	1.2	3.2	6.6	-2.2	-2.6	-2.5	2.3	-0.4	1.2	-1.2	-2.5	-0.2	1.8	0.7	1.5
Qualifications: nursing, teaching	1.2	1.9	6.1	-1.3	-1.5	-1.3	2.5	-0.6	0.9	0.9	-1.8	1.2	1.2	1.0	1.5
Mineral and other dietary supplements	1.2	1.6	3.1	0.8	1.0	1.4	-1.8	1.2	-0.7	-1.3	1.4	-1.5	-1.3	-1.3	-0.8
Commuting to job workplace: Public transport	1.2	1.5	2.6	-1.1	-1.3	-1.2	0.8	1.4	-1.4	-1.6	-1.4	-1.5	0.0	0.2	-1.3
Alcohol drinker status: Previous	1.2	1.4	4.1	-2.0	-1.4	-0.7	0.7	0.1	0.4	1.3	-1.3	1.0	1.4	1.2	1.4
Rheumatoid Arthritis	1.1	1.5	2.7	1.6	1.6	0.8	1.5	1.1	0.6	1.4	1.6	1.4	-0.4	0.8	1.1
Weight	1.1	5.3	13.8	-0.9	-1.0	-1.5	1.8	-0.4	2.3	2.9	-1.3	3.2	3.7	2.8	3.2
Alcohol intake frequency.	1.1	2.6	6.2	-2.0	-2.5	-2.4	1.6	0.9	0.6	-0.1	-2.5	0.3	2.0	0.6	1.1
Breast cancer (self-reported)	1.1	1.4	5.8	-0.1	-0.6	-1.0	2.4	-0.9	1.6	-0.1	-1.0	0.0	0.4	1.8	1.3
Vascular/heart problems diagnosed by doctor	1.1	2.9	6.1	2.1	2.4	2.5	-2.0	0.1	-0.7	0.9	2.4	-0.2	-2.0	-0.7	-1.6
Primary Biliary Cirrhosis	1.0	1.4	6.8	-1.2	-1.4	-1.3	2.6	0.5	0.9	-0.1	-1.2	0.6	1.1	0.5	0.8
Hypothyroidism (self reported)	1.0	2.4	13.0	0.3	-0.4	-0.6	1.3	1.8	-3.6	-0.9	-0.0	-0.9	-1.1	-1.6	-2.1
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	5.2	-1.9	-1.7	-2.3	1.0	-0.5	0.1	0.7	-1.6	-0.2	0.6	0.4	0.0
Arm fat mass (right)	1.0	4.2	10.3	-0.7	-0.7	-1.6	1.8	-0.9	1.5	2.5	-1.1	2.4	3.2	2.8	2.9
Length of working week for main job	1.0	1.2	4.2	-1.0	-0.9	-0.9	0.8	-2.0	1.1	0.9	-1.0	0.3	0.8	1.5	0.7
Tense / ‘highly strung’	1.0	1.6	6.7	1.0	1.7	1.7	-1.5	-2.6	0.3	0.9	1.3	0.3	-0.8	0.1	-0.5
Whole body fat mass	1.0	4.1	10.0	-0.9	-0.9	-1.9	1.8	-1.4	1.5	2.2	-1.2	2.2	3.2	2.7	2.8
Overall health rating	1.0	2.2	5.3	-1.2	-1.8	-2.3	1.7	-1.5	0.7	0.2	-2.1	0.4	2.2	0.6	0.9
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	5.7	0.3	0.7	1.8	-2.4	0.8	0.1	-1.1	0.6	-0.9	-0.7	-1.3	-0.6
Arm fat mass (left)	1.0	4.0	9.8	-0.7	-0.7	-1.6	1.6	-0.9	1.7	2.6	-1.1	2.5	3.1	2.7	2.8
Wears glasses or contact lenses	1.0	1.2	3.2	0.5	0.1	-0.7	0.7	-0.8	-1.4	-1.7	0.3	-1.8	-1.0	-1.6	-0.6
Medication: Lisinopril	1.0	1.2	4.9	-0.4	-1.1	-1.1	1.6	2.2	0.5	-0.5	-1.3	0.7	1.1	0.7	0.6
Heart disease (siblings)	1.0	1.2	3.6	-0.8	-0.5	-0.7	-1.0	1.2	0.5	1.0	0.1	1.6	1.6	0.7	1.9
HDL Cholesterol	0.9	1.5	4.5	0.4	1.2	1.4	-2.1	0.2	-0.6	0.2	0.9	-0.4	-2.0	-0.9	-2.1
Angina	0.9	1.1	3.4	-0.9	-1.4	-1.8	1.7	-0.9	-0.2	0.1	-1.1	0.5	1.0	0.6	0.7
Current tobacco smoking	0.9	1.5	4.8	0.8	0.8	0.7	-1.3	0.9	-0.9	2.2	1.7	1.7	0.9	0.4	0.9
Serious illness, injury or assault to yourself	0.9	1.1	7.0	-0.6	-0.9	-1.3	2.6	-0.4	-0.7	0.2	-0.9	0.6	0.5	1.1	0.4
Worrier / anxious feelings	0.9	1.7	5.5	2.3	1.6	0.5	0.0	-1.9	-0.8	-0.7	1.9	-1.2	-0.7	-1.2	-0.1
Breastfed as a baby	0.9	1.1	3.3	1.0	0.8	1.0	-0.9	0.7	-0.7	-1.8	0.8	-1.4	-0.9	-1.3	-0.7
Ever highly irritable/argumentative for 2 days	0.9	1.1	4.9	-0.0	0.3	1.0	-2.2	0.7	-2.0	0.2	0.6	0.1	-0.8	-0.4	-1.1
Glaucoma (self-reported)	0.9	1.0	4.4	1.3	1.0	0.2	0.8	0.4	1.3	0.3	1.4	0.5	0.5	-0.2	2.1
High blood pressure (siblings)	0.9	1.2	3.8	-2.0	-1.6	-1.7	0.7	-0.7	0.6	-0.1	-1.7	-0.0	0.9	0.4	0.5
Mouth/teeth dental problems: Loose teeth	0.9	1.1	6.1	-0.6	-0.2	-0.6	0.8	2.5	-1.4	0.7	-0.4	1.0	1.1	0.3	0.4
Emphysema/chronic bronchitis	0.9	1.0	3.1	-1.1	-0.7	-1.5	0.8	1.4	-1.8	-0.2	-1.0	-0.1	0.1	0.5	-1.1
Medication: Ibuprofen	0.9	1.1	3.2	0.3	1.1	0.5	-0.5	1.8	0.8	1.4	0.6	1.8	0.7	1.2	0.4
Arm predicted mass (right)	0.9	4.4	11.5	-0.6	-0.6	-0.6	0.9	0.7	3.0	2.4	-0.8	3.2	3.4	2.1	2.9
Average weekly red wine intake	0.9	1.4	5.3	0.5	-0.0	-0.3	-0.1	-0.5	-0.5	-2.3	0.1	-2.3	-1.5	-1.2	-1.1
Basal metabolic rate	0.9	5.0	12.8	-0.7	-0.7	-0.7	1.1	0.5	2.7	2.9	-1.0	3.5	3.6	2.5	3.0
Arm fat-free mass (left)	0.9	4.7	13.4	-0.9	-0.9	-0.8	0.9	1.0	2.6	2.5	-1.2	3.3	3.7	2.2	2.9
Age started oral contraceptive pill	0.9	1.1	3.4	1.3	1.4	1.6	0.5	-1.5	-0.4	-0.1	0.8	0.1	-1.8	0.2	-0.8
Heart attack/myocardial infarction (self-reported)	0.9	1.1	3.2	-1.0	-0.9	-1.0	1.2	-1.2	0.5	1.0	-0.8	1.2	1.8	0.5	1.2
Arm predicted mass (left)	0.9	4.7	13.2	-0.7	-0.7	-0.5	0.9	1.2	2.6	2.5	-1.0	3.5	3.6	2.1	3.0
Ulcerative Colitis (UC)	0.8	1.5	5.5	-2.4	-2.0	-1.3	-1.0	0.9	0.3	-0.4	-1.8	-0.2	0.6	0.8	-0.3
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	3.9	1.1	0.3	0.7	-1.0	1.2	-0.8	-0.7	0.5	-0.5	-0.2	-2.0	-0.7
Stomach or abdominal pain in last month	0.8	0.9	3.4	-0.5	-0.9	-1.8	1.0	0.9	-0.5	-1.0	-1.2	-0.4	-0.1	-1.0	-1.1
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	3.1	-0.8	-1.0	-1.8	1.2	-0.3	0.4	0.1	-0.9	0.1	1.5	1.0	1.2
Trunk fat mass	0.8	3.4	8.4	-0.9	-0.9	-1.7	1.6	-1.3	1.0	2.0	-1.2	2.0	2.9	2.7	2.5
Waist circumference	0.8	3.0	7.2	-0.1	-0.4	-1.6	1.6	-1.8	2.1	1.6	-0.6	1.5	2.7	1.8	2.6
Arm fat percentage (right)	0.8	3.2	6.7	-0.7	-0.8	-1.8	2.0	-1.8	0.6	2.0	-1.0	1.5	2.5	2.6	2.5
Trunk fat-free mass	0.8	4.6	12.0	-0.8	-0.7	-0.6	0.5	0.9	2.9	2.7	-1.0	3.5	3.4	2.3	2.7
Hair/balding pattern: Pattern 3	0.8	1.2	2.9	0.7	0.6	1.6	-0.4	0.5	-1.4	-0.7	0.9	-0.5	-1.4	-1.7	-1.4
Number of live births	0.8	1.1	4.2	-0.9	-0.7	-1.1	0.7	0.6	0.4	1.5	-1.2	1.3	0.8	2.0	0.2
Pulse rate	0.8	1.3	6.0	-0.6	-1.3	-1.0	-0.4	-1.2	-0.1	-1.7	-0.9	-2.4	-0.8	-0.6	-0.8
Noisy workplace	0.8	0.9	2.7	-0.2	0.4	-0.3	0.3	-1.3	1.1	1.6	-0.2	1.6	0.2	1.6	0.6
Mouth/teeth dental problems: Dentures	0.8	1.3	4.7	-0.6	-0.4	-0.7	0.2	0.7	-0.0	2.2	0.2	1.8	1.3	1.8	1.2
Illnesses of mother	0.8	0.9	3.3	0.2	0.2	1.8	-1.1	0.1	-1.4	-0.5	0.3	-1.0	-0.8	-0.9	-1.4
Trunk predicted mass	0.8	4.7	12.2	-0.8	-0.7	-0.6	0.6	1.0	2.9	2.7	-1.0	3.5	3.4	2.2	2.8
Arm fat-free mass (right)	0.8	4.1	10.9	-0.5	-0.3	-0.4	0.6	1.0	2.9	2.5	-0.6	3.3	3.3	1.9	2.7
Whole body fat-free mass	0.8	4.7	11.7	-0.7	-0.7	-0.6	1.0	0.7	2.9	2.7	-1.0	3.4	3.4	2.3	2.9
Whole body water mass	0.8	4.5	11.7	-0.5	-0.5	-0.5	0.9	0.8	2.8	2.7	-0.8	3.4	3.3	2.2	2.8
Sensitivity / hurt feelings	0.7	1.2	4.3	0.6	-0.9	-1.0	1.3	-0.6	-1.0	-2.0	-0.9	-2.1	0.5	-0.2	-0.3
Leg fat-free mass (left)	0.7	3.8	8.9	-0.2	-0.3	-0.5	1.5	0.2	2.4	2.5	-0.7	3.0	3.0	2.2	2.7
Relative age voice broke	0.7	1.0	4.4	0.5	-0.6	-0.8	0.5	-1.0	-0.6	-1.8	-0.6	-2.1	-0.6	-0.8	-0.4
Medication: Atenolol	0.7	0.9	2.9	-0.8	-1.2	-1.5	1.7	0.6	0.0	-0.1	-1.3	-0.0	1.2	0.1	0.4
Leg predicted mass (left)	0.7	3.6	8.7	-0.1	-0.3	-0.4	1.4	0.3	2.4	2.5	-0.6	3.0	2.9	2.2	2.7
Hearing difficulty/problems with background noise	0.7	1.1	4.1	-0.4	-0.0	-1.0	1.6	-2.0	0.5	1.0	-0.1	0.4	0.2	1.7	0.9
Qualifications: None of the above	0.7	1.4	4.1	-1.2	-1.7	-1.3	-0.0	-1.3	-0.4	-1.5	-1.4	-2.0	0.6	-0.7	-0.1
Heart attack	0.7	0.9	3.1	-0.9	-0.8	-0.8	1.0	-1.0	0.2	0.8	-0.8	1.1	1.8	0.4	1.1
Allergy	0.7	1.6	5.0	0.3	0.1	0.7	-0.8	-1.5	2.2	1.3	0.2	1.4	1.5	0.8	2.2
Fluid intelligence score	0.7	1.4	4.5	0.4	-0.2	-0.1	0.0	0.8	-0.9	-2.1	0.1	-1.6	-1.5	-1.6	-1.7
Hip circumference	0.7	3.1	6.6	-0.5	-0.5	-1.0	1.8	-1.2	2.0	2.4	-1.0	2.3	2.6	1.8	2.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.9	-0.0	0.5	-0.3	0.1	1.5	1.2	1.1	0.1	1.7	0.7	1.2	0.4
Birth weight of first child	0.7	1.2	3.1	-0.8	-0.5	0.6	-0.0	0.6	0.6	1.5	-0.6	1.8	1.4	1.7	1.3
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.9	1.2	1.4	1.7	-0.4	0.6	-1.1	0.2	1.6	0.5	-1.1	-0.2	-0.8
Body fat percentage	0.7	2.6	5.5	-0.7	-0.8	-1.8	1.6	-2.0	0.4	1.5	-1.0	1.1	2.4	2.3	2.3
Worry too long after embarrassment	0.7	1.2	5.7	-0.8	-1.3	-2.4	1.8	-0.1	-0.2	-0.0	-1.3	0.2	1.1	0.3	0.5
Angina (self-reported)	0.7	1.0	3.3	-0.6	-1.3	-1.8	1.8	-0.7	-0.4	-0.2	-1.0	0.2	0.9	0.4	0.5
Leg fat-free mass (right)	0.7	3.8	9.4	-0.5	-0.7	-0.6	1.4	0.4	2.3	2.5	-1.0	3.0	3.1	2.0	2.6
Arm fat percentage (left)	0.7	2.7	5.7	-0.2	-0.4	-1.5	1.9	-2.0	0.8	1.8	-0.6	1.4	2.2	2.4	2.3
Friendships satisfaction	0.7	0.8	2.3	0.6	0.5	0.7	-1.0	1.2	-0.6	-0.9	0.7	-0.6	-1.0	-1.5	-1.1
Commuting to job workplace: Walk	0.7	0.7	3.9	0.4	-0.2	0.2	-0.5	2.0	-1.2	-1.2	-0.3	-0.7	-0.0	-0.6	-0.8
Medication: Gliclazide	0.7	0.8	3.5	0.1	0.6	1.3	-1.9	1.7	-0.2	0.4	0.6	0.4	-0.4	-0.2	-0.9
Smoking status: Current	0.7	1.2	4.4	0.6	0.6	0.7	-1.2	0.4	-0.9	2.1	1.4	1.5	0.9	0.4	0.9
Leg predicted mass (right)	0.7	3.9	9.9	-0.5	-0.7	-0.6	1.4	0.5	2.4	2.5	-1.0	3.0	3.1	2.1	2.6
Guilty feelings	0.7	1.1	5.3	0.6	0.8	0.3	0.2	-1.0	-0.4	2.3	0.5	1.7	0.5	1.4	0.5
Mother’s age at death	0.7	0.9	3.2	1.1	0.7	0.4	-0.1	1.2	-1.8	-0.8	0.8	-0.5	-1.0	-0.8	-0.9
High cholesterol (Self-reported)	0.7	1.2	3.5	1.2	0.8	0.8	-1.0	-0.1	-0.7	-1.3	1.2	-1.1	-1.1	-1.9	-0.9
Medication: Bendroflumethiazide	0.7	1.1	3.5	-1.1	-0.7	-0.6	1.9	-0.9	1.4	-0.2	-1.1	0.3	0.8	0.9	1.3
Number of operations (self-reported)	0.7	1.0	2.7	1.2	0.4	-1.4	1.6	0.4	-0.5	-0.8	-0.1	-0.6	-0.9	-1.6	-1.1
Diastolic blood pressure, automated reading	0.7	2.2	6.2	-1.5	-1.2	-1.5	0.2	2.4	0.5	1.3	-1.4	1.9	2.5	0.5	1.3
Intelligence (Savage-Jansen 2018)	0.6	2.0	5.3	0.5	-0.5	0.2	0.3	0.1	-0.7	-2.3	-0.4	-2.0	-2.1	-1.8	-2.3
Ulcerative Colitis	0.6	0.9	3.1	-1.8	-1.5	-0.6	-0.9	0.7	0.6	-0.0	-1.3	0.1	0.2	1.3	-0.3
Type 2 Diabetes (T2D) (2018)	0.6	1.1	4.3	-0.0	-1.3	-0.9	1.1	0.4	0.6	-0.5	-1.1	-0.1	2.1	0.7	1.8
Lung FVC	0.6	3.2	12.0	0.3	1.1	1.8	-3.5	1.9	-1.5	-0.0	1.3	0.0	-2.6	-0.9	-2.6
Impedance of leg (right)	0.6	3.1	7.7	-0.6	-0.3	-0.0	-2.4	0.1	-2.6	-2.4	0.2	-2.8	-2.0	-0.9	-2.2
Taking other prescription medications	0.6	0.9	7.8	0.6	-0.2	-0.9	2.8	0.6	-0.7	-0.6	-0.2	-0.3	-0.5	-0.1	0.0
Hayfever, allergic rhinitis or eczema	0.6	1.4	3.9	0.2	0.3	0.0	0.2	0.4	-1.3	-1.5	0.1	-2.0	-1.9	-1.0	-2.0
Multivitamins +/- minerals	0.6	0.8	2.9	0.6	0.6	1.0	-1.2	1.4	-1.7	0.1	0.6	0.5	0.4	-0.7	-0.2
High blood pressure (mother)	0.6	0.8	2.9	-0.7	-1.1	-1.4	0.7	0.0	-0.4	-1.7	-0.7	-1.1	-0.0	-1.0	0.1
Impedance of leg (left)	0.6	3.0	8.0	-0.9	-0.8	-0.3	-2.4	0.1	-2.5	-2.5	-0.3	-2.8	-1.8	-1.1	-2.2
Alcohol usually taken with meals	0.6	0.9	4.2	0.1	-0.4	-0.2	0.7	0.2	0.4	-2.0	-0.7	-1.6	-0.8	-1.2	-0.7
Hair/balding pattern: Pattern 2	0.6	0.7	3.8	-1.9	-0.4	-0.2	-0.6	-1.3	0.5	0.5	-1.0	0.4	-0.0	1.0	-0.2
Had menopause	0.6	0.8	2.8	1.3	0.9	0.1	0.6	-0.7	-0.2	-1.0	0.5	-0.8	-1.7	-0.5	-1.0
Qualifications: A levels/AS levels or equivalent	0.6	1.4	4.2	1.2	1.3	2.0	-1.5	-0.3	-0.8	-0.1	1.5	0.1	-1.6	-0.5	-1.3
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.1	1.3	1.2	0.6	0.4	0.1	-1.5	-0.3	1.3	-0.8	-0.5	-0.6	-0.1
Hair/balding pattern: Pattern 4	0.6	1.4	5.2	-1.4	-1.7	-2.3	0.3	0.7	-0.7	1.1	-1.2	0.5	1.5	0.0	-0.4
Medication: Amlodipine	0.6	0.8	3.0	-1.0	-1.3	0.2	-0.4	-0.9	-0.2	-1.7	-0.6	-1.1	0.6	-1.0	0.8
Chronic bronchitis/emphysema (mother)	0.6	0.6	1.8	-1.1	-0.6	-1.4	0.6	0.4	0.3	0.4	-1.1	0.3	0.6	1.3	0.5
Eye problems/disorders: None of the above	0.6	0.7	2.0	-1.0	-0.8	-0.8	0.7	-1.4	0.8	-0.7	-1.1	-0.7	-0.7	-0.2	-0.4
Medication: Seretide 50 evohaler	0.6	0.7	1.8	1.4	1.0	0.2	-0.5	1.0	-0.5	-0.5	1.1	-0.5	-0.7	-1.0	-1.0
Had major operations	0.6	0.7	1.7	-0.1	-0.6	-1.3	1.0	0.3	-0.7	-1.2	-0.6	-0.8	-0.4	-1.2	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.7	-0.1	0.2	-0.0	-0.6	-0.4	0.4	1.6	0.5	1.6	0.7	1.0	1.0
Handedness (chirality/laterality): Left-handed	0.6	0.8	2.4	-1.6	-1.0	-0.7	0.4	-0.1	0.7	0.8	-1.4	0.9	0.9	0.6	0.1
Diabetes diagnosed by doctor	0.6	1.0	2.7	-0.2	-1.3	-1.1	1.3	0.4	0.4	-0.7	-1.3	-0.2	1.6	0.4	1.5
Eye problems/disorders: Cataract	0.6	0.7	2.0	1.4	1.1	1.2	-0.4	0.7	-0.1	-0.2	1.4	-0.1	-0.9	-0.1	0.1
Miserableness	0.6	1.0	3.2	0.3	-0.6	-1.4	1.1	1.0	-0.1	1.0	-0.6	0.8	1.3	1.8	1.0
Eye problems/disorders: Glaucoma	0.6	0.7	2.9	1.2	0.9	0.1	0.6	0.1	0.8	-0.1	1.2	-0.0	0.4	-0.6	1.7
Irritability	0.6	1.0	3.1	1.7	1.8	0.9	0.1	-0.1	-1.2	-0.1	1.5	-0.2	-0.7	0.0	-0.8
Fractured/broken bones in last 5 years	0.6	0.8	3.2	-0.5	-1.0	-1.8	1.4	-0.1	-0.5	-0.8	-0.9	-0.8	0.4	0.4	-0.5
Depressed Affect (Nagel 2018)	0.5	1.1	4.5	0.6	-0.1	-1.1	0.9	1.1	-0.2	1.4	-0.1	1.0	1.1	2.1	0.9
Schizophrenia vs Biploar Disorder	0.5	0.6	1.9	-0.4	-0.3	0.2	-0.7	0.0	-1.2	-1.4	-0.0	-1.2	-0.5	-1.1	-0.7
Verbal and Numeric Reasoning (VNR)	0.5	1.2	3.7	0.6	-0.2	0.4	-0.2	1.0	-0.2	-1.9	0.1	-1.3	-1.6	-1.5	-1.6
Breast Cancer	0.5	1.1	3.3	1.0	1.6	1.8	-0.5	0.8	1.2	0.9	1.1	0.9	0.4	0.5	0.8
Lupus	0.5	0.7	2.4	-0.9	0.1	-0.1	-0.1	-0.0	0.6	1.4	0.3	1.5	0.8	0.8	1.3
Triglycerides	0.5	0.8	1.6	-0.4	0.1	-0.5	-0.5	0.3	1.2	1.1	0.1	1.3	1.2	1.1	1.1
Blood Platelet Count	0.5	5.8	15.6	1.8	-0.0	0.9	-0.6	0.9	-3.0	-3.9	-0.2	-3.5	-3.0	-2.0	-4.0
Systolic Blood Pressure	0.5	2.6	7.5	-2.7	-2.7	-1.8	-0.2	1.1	-0.3	-1.5	-2.4	-1.2	1.1	-0.9	0.1
Allergy or Eczema	0.5	1.3	3.8	0.0	-0.1	-0.2	0.8	-0.4	-1.3	-1.3	-0.3	-1.9	-1.9	-0.5	-1.9
Respiratory disease	0.5	1.0	3.5	-1.3	-0.8	-1.4	0.7	0.6	-1.9	0.6	-1.0	0.6	0.4	0.9	-0.9
Hand grip strength (left)	0.5	1.3	4.4	1.0	1.2	1.6	-2.1	1.4	-0.9	0.3	1.4	0.6	-0.2	-0.8	-0.4
Number of treatments/medications taken	0.5	0.9	4.5	-0.2	-0.6	-1.3	2.1	0.4	-0.7	-1.1	-0.8	-0.9	0.0	-0.8	-0.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	3.5	0.3	-0.5	-1.0	1.9	-0.4	-0.8	-0.7	-0.5	0.1	-0.2	-0.9	-0.4
Pack years adult smoking proportion	0.5	0.8	2.0	0.5	0.9	-0.0	-1.0	0.4	-0.2	1.0	1.4	1.3	1.0	0.7	1.1
Maternal smoking around birth	0.5	0.7	1.6	-1.3	-0.6	-0.4	-0.5	-0.1	0.2	1.1	-1.0	1.1	1.3	1.0	0.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.8	0.9	1.3	0.2	1.2	-0.4	0.5	0.7	0.7	0.9	-0.5	-0.4	0.1
Past tobacco smoking	0.5	0.9	2.7	1.6	0.6	0.7	-0.0	-0.6	-0.1	-1.5	0.7	-1.2	-0.7	-1.3	-0.8
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.8	1.1	1.4	0.1	0.0	0.9	-0.7	0.8	1.3	0.5	0.1	0.3	0.4
Medication: Simvastatin	0.5	0.7	2.8	0.4	-0.5	-0.8	1.2	-1.7	0.3	-1.1	-0.3	-0.6	0.3	-0.6	0.9
Asthma	0.5	1.1	2.3	-1.5	-1.0	-1.5	0.9	1.4	-1.4	0.3	-1.1	0.4	0.4	0.7	-0.6
Medication: Lansoprazole	0.5	0.5	1.5	0.9	0.7	-0.1	-0.4	0.2	-1.2	-0.7	0.4	-1.0	-0.7	-1.1	-0.5
Headache pain in last month	0.5	0.9	4.9	-0.6	-0.4	-0.8	0.1	2.2	0.4	-0.8	-0.6	-0.1	-1.2	0.1	-1.5
Exposure to tobacco smoke outside home	0.5	0.7	2.8	-0.2	-0.4	-0.9	1.7	-1.1	0.1	1.0	-0.4	0.5	0.8	0.9	0.7
Pulse wave peak to peak time	0.5	0.6	1.9	0.1	-0.7	-0.1	0.4	0.2	-1.2	-1.4	-0.5	-1.1	-0.0	-0.8	-1.1
Health satisfaction	0.5	0.6	2.6	1.6	1.3	1.1	-0.4	0.2	0.1	0.5	1.2	0.1	0.1	0.1	0.2
Shortness of breath walking on level ground	0.5	0.5	1.7	1.3	0.9	0.5	0.0	0.6	-1.0	-0.9	0.9	-0.3	-0.2	-0.7	-0.0
Comparative height size at age 10	0.5	2.5	10.7	0.1	1.0	0.4	-1.6	1.8	0.3	3.0	0.8	3.3	0.9	1.5	0.4
Loneliness, isolation	0.5	0.8	3.0	1.7	0.9	0.2	1.1	1.1	-0.3	0.6	0.6	0.2	-0.1	1.4	0.1
Medication: Atorvastatin	0.5	0.6	2.0	-0.8	-0.5	0.2	-1.0	0.4	-1.3	0.0	-0.2	-0.0	-0.4	-1.0	-1.4
Depression (Nagel 2018)	0.4	0.6	2.4	0.9	-0.3	-0.5	0.5	1.5	-1.6	0.2	-0.3	-0.1	0.9	0.4	0.1
Major Depression (MDD)	0.4	0.5	1.5	0.6	-0.6	-0.7	1.2	1.1	-0.6	-0.7	-0.6	-0.7	0.5	-0.1	-0.4
Crohns Disease (2012)	0.4	0.7	1.6	1.1	1.0	0.7	-0.0	-0.2	-0.8	-0.9	1.2	-1.1	-1.1	-0.4	-0.4
Schizophrenia (2014)	0.4	1.0	2.6	-0.1	-0.2	0.6	-0.9	-1.0	-0.9	-1.6	0.0	-1.6	-1.2	-1.3	-0.7
Chronotype (morning person)	0.4	0.9	2.4	-1.3	-1.5	-0.9	0.4	1.2	-0.5	0.5	-1.5	0.9	0.4	0.0	-0.6
Frequency of depressed mood in last 2 weeks	0.4	0.5	2.9	1.7	0.6	-0.1	-0.0	-0.2	-1.4	-0.0	0.7	-0.7	0.0	-0.6	-0.2
Ever used hormone-replacement therapy (HRT)	0.4	0.4	1.0	0.9	0.9	-0.4	0.6	0.1	-0.1	1.0	0.6	0.8	-1.0	-0.1	-0.6
Systolic blood pressure, automated reading	0.4	1.3	2.4	-1.5	-1.6	-1.5	-0.1	1.4	-0.7	-1.0	-1.5	-0.6	1.3	-0.9	0.1
Medication: Metformin	0.4	0.5	1.9	0.5	-0.2	-0.2	0.3	0.9	0.6	0.5	-0.3	0.5	1.4	0.4	1.3
Trunk fat percentage	0.4	1.8	4.4	-0.6	-0.7	-1.6	1.4	-1.5	-0.0	1.1	-0.8	0.9	1.9	2.1	1.8
Hand grip strength (right)	0.4	1.2	2.2	1.2	1.2	1.4	-1.4	1.5	-1.0	0.2	1.4	0.4	-0.8	-0.8	-0.7
Fed-up feelings	0.4	0.7	1.9	0.6	0.1	-0.8	0.6	-0.2	0.0	1.3	0.3	1.0	1.1	1.4	1.2
Qualifications: CSEs or equivalent	0.4	0.5	1.8	-0.5	0.0	-0.4	-0.3	-0.2	0.7	1.3	0.1	0.8	0.4	0.9	1.1
Supplements: Glucosamine	0.4	0.5	2.0	-0.0	0.7	0.3	-0.4	-0.6	-0.1	1.4	0.7	1.4	0.4	0.6	0.4
Chronic bronchitis/emphysema (father)	0.4	0.5	1.7	-0.2	0.0	-0.9	0.9	0.9	-0.0	1.3	-0.3	0.8	0.9	-0.4	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.2	0.2	-0.4	-1.1	0.7	-0.5	0.4	0.9	-0.9	0.9	1.0	1.0	0.4
Forced vital capacity (FVC)	0.4	1.5	7.9	0.2	0.3	1.4	-2.8	2.0	-1.0	0.2	0.6	0.3	-1.1	-0.2	-1.3
Father’s age at death	0.4	0.5	1.5	0.4	0.6	0.6	0.1	0.8	0.2	1.2	0.6	1.1	-1.0	0.1	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.2	-0.4	-0.6	-1.5	0.9	0.9	-0.9	0.3	-0.5	0.5	1.2	0.5	0.6
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	8.0	0.2	0.5	1.1	-2.8	1.6	-0.5	0.6	0.7	0.5	-0.9	0.1	-0.9
Prospective memory result	0.4	0.5	2.2	0.2	0.5	0.8	-0.7	0.9	-1.5	0.5	0.4	0.5	0.1	0.3	-0.5
Pulse wave Arterial Stiffness index	0.4	0.5	1.6	-0.2	0.7	0.2	-0.6	0.1	1.0	1.3	0.5	1.1	-0.1	0.7	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	3.2	-0.4	-0.1	-0.1	-0.1	-0.5	-0.8	1.8	-0.3	1.2	0.9	1.0	0.1
Blood clot in the leg (DVT)	0.4	0.5	2.3	-0.5	-0.8	-0.6	1.5	1.0	0.5	-0.5	-0.6	0.1	-0.1	-0.1	-0.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.7	0.8	1.3	0.5	0.5	1.0	0.8	1.3	0.8	0.9	-0.1	1.0	0.6
Gout (self-reported)	0.4	0.5	2.0	0.1	-0.1	0.1	1.2	0.4	1.2	-0.1	-0.3	-0.0	0.1	1.1	1.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.9	-1.4	-0.6	-1.3	0.8	0.5	-0.4	-0.3	-1.0	-0.2	0.5	0.4	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.3	0.3	0.6	1.0	-1.0	0.1	-1.1	-0.0	0.7	-0.4	-0.7	-1.0	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.4	1.2	0.9	0.1	0.2	1.0	0.3	-0.7	1.1	-0.4	-0.4	-0.2	0.2
Supplements: Vitamin C	0.4	0.4	1.2	-0.2	-1.1	-0.4	-0.2	-0.6	-0.6	-0.4	-0.9	-0.6	0.6	-1.0	-0.5
Smoking status: Previous	0.4	0.6	1.7	-1.3	-0.3	-0.2	0.2	0.6	0.8	0.8	-0.8	0.7	0.4	1.1	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	5.0	0.1	-0.0	0.4	-1.4	2.2	-1.3	-0.0	0.2	0.2	-0.1	0.0	-0.9
Mood swings	0.4	0.8	2.5	1.5	1.1	0.5	-0.1	-1.0	-1.6	-0.1	1.3	-0.4	0.4	0.4	0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.5	-1.2	-1.1	-0.6	0.9	1.1	0.1	-0.4	-1.0	0.3	0.7	0.3	0.7
Asthma (self-reported)	0.4	0.9	2.2	-1.4	-0.7	-1.5	0.8	0.9	-1.5	0.4	-1.0	0.3	0.1	0.5	-0.9
Ever taken oral contraceptive pill	0.4	0.5	2.5	0.5	0.7	0.8	-1.6	0.4	0.5	0.4	0.6	0.8	-0.1	0.4	0.4
Illnesses of father: High blood pressure	0.4	0.5	0.9	-1.0	-1.0	-0.7	-0.5	-0.9	-0.8	-0.4	-0.6	-0.9	-0.0	-0.3	-0.3
Alcohol drinker status: Never	0.4	0.5	1.4	-0.6	-1.2	-0.9	0.8	0.0	-0.8	-0.5	-1.1	-0.4	0.0	-0.1	-0.4
Average weekly beer plus cider intake	0.4	0.6	2.8	-1.1	-1.1	-1.7	0.2	0.5	-0.5	0.6	-0.6	0.0	0.5	0.7	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	2.7	-0.6	-0.9	-0.6	1.6	1.0	0.4	-0.8	-0.8	-0.2	-0.1	-0.3	-0.1
Neuroticism (Nagel 2018)	0.3	0.6	1.8	1.3	0.7	-0.3	0.8	-0.3	-1.1	0.9	0.6	-0.0	-0.1	1.3	0.1
Worry (Nagel 2018)	0.3	0.7	4.9	1.1	0.8	-0.0	0.3	-2.2	-0.3	0.2	0.7	-0.6	-0.6	0.6	0.3
Irritable Bowel Disease (IBD)	0.3	0.6	1.5	-1.2	-1.2	-0.7	-0.5	0.8	-0.2	-0.8	-1.0	-0.7	0.4	0.9	-0.2
Ovarian Cancer	0.3	0.4	1.9	0.3	-0.2	-0.3	1.0	1.4	-0.7	0.4	0.0	0.2	-0.2	0.7	0.3
HbA1C	0.3	0.3	1.5	-0.2	-0.7	-0.4	0.3	-0.6	-0.7	0.1	-0.6	-0.0	1.2	0.1	0.2
Type 2 Diabetes (T2D) (2012)	0.3	0.3	2.1	0.3	-0.2	0.2	0.4	0.0	0.6	-0.3	0.5	-0.1	0.6	-0.2	1.5
Heel T-Score	0.3	2.5	9.1	-3.0	-1.8	-1.2	0.8	-0.1	2.2	1.6	-1.8	1.0	0.8	1.7	0.7
Waist Hip Ratio (WHR)	0.3	1.2	4.0	-0.5	-0.8	-2.0	0.1	-1.6	1.2	-1.4	-0.4	-1.2	0.8	0.5	1.3
Neuroticism	0.3	0.6	2.2	1.0	0.8	-0.1	0.3	-1.5	-1.0	0.9	0.4	-0.2	-0.4	1.0	-0.6
Tanning	0.3	4.3	11.0	2.7	2.9	3.3	-2.4	1.5	-0.1	1.8	3.0	2.0	-0.4	-0.4	0.2
Medication for hormone replacement therapy	0.3	0.3	0.8	-0.9	-0.7	-0.8	0.0	-0.4	0.3	0.4	-0.7	0.5	0.4	-0.5	0.2
Vitamin and mineral supplements	0.3	0.4	1.9	-0.5	-0.2	-0.4	0.3	-1.1	1.4	-0.5	-0.1	-0.7	-0.3	0.9	0.3
Nervous feelings	0.3	0.5	1.7	0.8	0.4	-0.2	0.8	-1.3	0.5	0.1	0.3	-0.1	0.6	0.8	1.3
Diabetes (self-reported)	0.3	0.4	1.0	0.4	-0.7	-0.3	0.5	0.6	-0.1	-0.9	-0.6	-0.6	0.8	-0.2	1.0
Neuroticism score	0.3	0.6	2.3	1.5	0.9	-0.0	0.8	-0.9	-0.7	0.7	0.8	0.1	0.5	0.7	0.4
Time employed in main current job	0.3	0.4	1.7	-0.4	-0.2	-0.6	-0.9	-0.3	0.7	0.4	0.2	0.4	0.6	0.4	1.3
Depression (self-reported)	0.3	0.3	0.9	0.4	-0.1	0.0	0.9	0.1	0.7	0.8	-0.2	0.4	0.7	0.5	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	2.4	-0.1	0.5	0.3	0.5	-1.6	0.2	0.1	0.3	0.1	-0.8	0.6	0.1
Medication: Blood pressure	0.3	0.5	1.4	-0.9	-1.2	-0.8	0.1	-1.0	-0.0	-0.6	-1.1	-0.3	0.6	-0.5	-0.3
Number of full sisters	0.3	0.3	1.5	-0.5	-0.6	-0.5	1.2	-0.1	-0.1	0.7	-0.3	0.4	0.4	-0.1	0.7
Suffer from ‘nerves’	0.3	0.5	1.7	1.3	0.8	-0.5	1.1	-1.3	0.0	-0.3	0.4	-0.5	-0.2	0.1	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.3	-0.5	-0.6	-0.1	0.4	-1.2	-0.3	0.5	-0.7	0.3	0.3	0.3	0.7
Illnesses of father: Heart disease	0.3	0.4	1.1	0.4	0.9	0.4	-0.6	-0.9	-0.1	0.3	1.0	0.6	0.0	0.6	0.9
Back pain experienced in last month	0.3	0.5	1.6	-0.9	-0.6	-1.3	-0.2	0.4	0.9	0.3	-1.1	0.2	0.2	0.1	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	3.5	0.4	0.5	0.3	-1.1	-0.1	0.2	1.9	0.7	1.4	-0.2	0.7	0.2
Hearing aid user	0.3	0.3	1.1	-0.6	-0.1	-1.0	-0.3	0.3	0.2	0.6	-0.1	0.5	1.0	0.6	0.1
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.1	0.7	1.0	0.1	-0.3	-0.5	-0.2	-0.0	1.0	-0.3	-1.1	-0.2	-0.5
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.9	0.0	-0.6	-1.4	0.7	1.0	0.6	-0.5	-0.7	-0.4	0.4	0.5	-0.1
Risk taking	0.3	0.5	2.9	0.2	0.9	1.7	-1.0	-0.4	0.1	0.1	0.9	0.3	-0.4	0.3	-0.2
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.5	-0.2	0.3	-0.5	-1.2	0.9	-0.9	-0.2	0.4	-0.5	-0.3	-0.5	-0.6
Ever depressed for a whole week	0.3	0.3	0.9	0.5	0.9	-0.0	0.2	0.9	-0.8	-0.3	0.7	-0.7	-0.2	-0.2	-0.3
Myopia	0.3	0.4	2.0	0.1	0.2	-0.3	0.9	1.4	-0.3	0.2	0.3	0.6	0.6	0.6	0.5
Pack years of smoking	0.3	0.4	1.6	0.4	0.7	-0.1	-1.0	0.0	-0.3	0.4	1.3	0.7	0.7	0.5	0.8
Alzheimer’s Disease (in father)	0.2	0.2	0.8	0.1	-0.4	-0.6	0.7	-0.4	0.5	0.9	-0.2	0.2	0.4	0.1	0.3
Prostate Cancer	0.2	0.3	0.8	-0.4	-0.7	-0.8	0.7	-0.2	-0.9	-0.4	-0.8	-0.5	0.3	0.0	-0.4
Mean Putamen Volume	0.2	0.2	1.0	0.1	0.6	-0.4	-0.2	0.8	-0.3	0.3	0.1	0.5	-0.3	-0.1	-1.0
Blood Red Count	0.2	1.9	5.9	-0.1	0.1	-1.4	2.4	-1.3	0.9	0.9	-0.0	0.6	1.1	2.4	2.1
Lung FEV1/FVC ratio	0.2	1.0	8.8	-0.1	0.5	0.6	-3.0	1.1	0.3	0.5	0.7	-0.0	-0.1	0.2	-0.1
Severe depression (siblings)	0.2	0.3	0.7	-0.5	-0.2	-0.8	0.6	0.8	-0.6	0.3	-0.1	0.4	0.6	0.3	0.6
Average weekly fortified wine intake	0.2	0.3	0.9	-0.3	-0.5	-0.3	0.2	0.7	-0.1	0.9	-0.6	0.7	0.2	-0.1	-0.6
Alcohol intake versus 10 years previously	0.2	0.4	1.3	-0.3	-0.6	-0.0	-0.6	0.4	1.1	-0.4	-0.6	-0.1	0.9	0.5	0.6
Medication: Cholesterol lowering	0.2	0.3	0.9	-0.5	-0.8	-0.4	0.0	-0.9	-0.4	0.2	-0.5	0.6	0.7	-0.1	0.3
Lung cancer (father)	0.2	0.2	0.5	-0.7	-0.5	-0.6	-0.7	0.5	-0.0	-0.4	-0.6	-0.4	0.3	-0.1	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	3.9	0.1	0.5	0.7	-2.0	0.7	0.1	1.3	0.6	0.9	-0.5	0.9	-0.2
Peak expiratory flow (PEF)	0.2	0.4	1.2	0.1	0.4	-0.2	-0.4	1.1	0.5	1.1	0.1	0.9	-0.4	0.4	-0.2
Forced vital capacity (FVC), Best measure	0.2	0.8	4.2	0.0	0.5	1.1	-2.0	0.7	-0.4	1.1	0.8	0.9	-0.5	0.8	-0.3
Migraine (self-reported)	0.2	0.3	0.9	-0.3	0.5	-0.1	-0.9	0.1	0.8	0.4	0.4	0.6	-0.4	-0.6	-0.6
Medication: Omeprazole	0.2	0.3	1.0	0.3	0.4	0.6	-0.7	0.5	-0.5	0.5	0.6	0.4	0.0	-1.0	-0.1
Pulse rate, automated reading	0.2	0.6	1.9	-0.6	-0.6	-0.8	-1.2	-1.4	-0.4	-0.8	-0.5	-1.3	-0.1	-0.4	-0.3
Medication: Aspirin	0.2	0.2	1.0	1.0	0.2	0.3	0.6	-0.2	-0.4	0.0	0.4	0.5	0.3	0.3	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	1.2	0.3	-0.1	0.3	0.4	1.1	-0.2	0.9	0.1	0.5	0.0	0.5	0.2
Medication: Aspirin	0.2	0.3	1.6	1.3	0.5	0.3	0.6	0.0	-0.7	-0.3	0.8	0.1	-0.2	-0.2	0.1
Illnesses of father: None of the above (group 1)	0.2	0.2	1.0	-0.1	-0.1	0.7	-0.1	-0.2	0.1	-1.0	-0.4	-0.5	-0.2	0.3	-0.2
Financial situation satisfaction	0.2	0.3	1.8	0.3	-0.4	-0.0	1.3	0.5	0.3	0.7	-0.3	0.4	-0.1	0.3	-0.4
Ever smoked	0.2	0.3	1.4	-0.8	-0.1	-0.2	-0.4	1.2	-0.8	0.5	0.1	0.3	-0.1	0.0	0.2
Commuting to job workplace: Cycle	0.2	0.2	0.9	-0.1	-0.1	-0.1	0.1	0.3	-0.8	1.0	0.2	0.6	-0.3	0.3	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.2	-0.2	0.0	-0.1	-0.1	0.3	0.2	1.0	-0.1	1.1	0.7	-0.5	0.6
Bipolar Disorder (2018)	0.1	0.2	1.0	-0.2	-0.1	-0.7	0.1	1.0	-0.0	0.1	-0.1	0.5	0.1	-0.5	-0.2
Schizophrenia (2018)	0.1	0.3	0.8	0.1	0.0	0.9	-0.9	-0.8	-0.2	-0.7	0.1	-0.6	-0.8	0.0	-0.1
Crohns Disease (2017)	0.1	0.3	1.2	0.2	-0.2	0.0	0.2	0.0	-0.8	-0.9	0.0	-1.1	0.0	0.7	-0.2
LDL Cholesterol	0.1	0.2	1.0	0.3	0.1	0.0	-0.5	1.0	-0.1	0.2	0.6	-0.1	-0.0	-0.7	-0.1
Height	0.1	1.6	6.1	1.4	1.0	0.6	-1.3	2.5	-2.1	-1.0	1.4	-0.5	-0.3	-0.7	-0.8
Hair Pigment	0.1	3.1	6.9	-2.1	-2.6	-2.5	1.6	0.6	2.1	-0.2	-2.6	0.3	1.8	0.5	1.3
Sitting height	0.1	0.8	6.2	-0.0	-0.9	-0.1	0.1	2.5	0.2	-0.9	-1.0	-0.1	0.7	-0.2	-0.3
Medication: Ramipril	0.1	0.2	1.0	-0.2	-0.3	0.1	-0.2	-1.0	-0.1	-0.0	-0.0	0.2	0.8	-0.3	0.4
Standing height	0.1	1.1	6.8	0.6	0.2	0.9	-2.0	2.6	-0.6	-0.4	0.5	0.1	-0.2	-0.2	-0.9
Number of full brothers	0.1	0.2	0.5	-0.7	-0.4	-0.6	-0.5	0.3	0.0	0.4	-0.6	0.3	-0.2	0.3	-0.2
Qualifications: College or University degree	0.1	0.2	0.7	0.2	0.1	0.1	0.1	0.2	0.2	-0.8	-0.2	-0.4	-0.9	0.3	-0.7
Unable to work because of sickness or disability	0.1	0.1	0.5	-0.5	0.1	-0.4	-0.3	-0.2	0.3	0.7	-0.3	0.4	-0.2	0.2	-0.4
Cholesterol lowering medication	0.1	0.2	0.5	0.7	0.4	0.1	0.6	-0.1	0.2	-0.6	0.5	-0.1	-0.2	-0.4	0.6
Bipolar Disorder or Schizophrenia	0.0	0.1	0.3	-0.1	-0.1	0.3	-0.6	0.0	-0.2	-0.4	0.0	-0.1	-0.6	-0.3	-0.2

Hub : Genes

LEPROT

Models

Trait associations