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chr11:7,714,238-9,679,183

Best TWAS P=7.45e-13 · Best GWAS P=1.76e-15 conditioned to 0.000172

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	STK33	0.18	0.18	lasso	9	0.20	3.8e-24	5.59	-6.2	6.1e-10	-0.71	1.00	0.00	FALSE
2	GTEx	Adipose Visceral Omentum	TRIM66	0.35	0.23	lasso	6	0.24	1.9e-12	-4.56	-6.0	1.8e-09	-0.58	0.87	0.13	FALSE
3	GTEx	Artery Aorta	TRIM66	0.33	0.29	lasso	10	0.30	6.5e-17	-4.56	-5.8	9.2e-09	-0.56	1.00	0.00	FALSE
4	GTEx	Brain Caudate basal ganglia	TRIM66	0.17	0.00	enet	29	0.08	2.6e-03	4.96	-6.2	6.0e-10	-0.71	0.11	0.43	FALSE
5	GTEx	Brain Caudate basal ganglia	RP11-152H18.3	0.23	0.01	enet	1	0.06	1.1e-02	7.17	7.2	7.4e-13	0.79	0.03	0.77	TRUE
6	GTEx	Breast Mammary Tissue	TRIM66	0.39	0.40	enet	31	0.45	2.4e-25	-4.56	-5.8	8.7e-09	-0.58	1.00	0.00	FALSE
7	GTEx	Breast Mammary Tissue (Male)	TRIM66	0.24	0.20	lasso	3	0.25	1.7e-06	-4.59	-5.8	7.5e-09	-0.57	0.02	0.91	FALSE
8	GTEx	Cells Transformed fibroblasts	TRIM66	0.48	0.32	enet	35	0.34	1.7e-26	-4.59	-5.3	1.2e-07	-0.52	1.00	0.00	FALSE
9	GTEx	Colon Sigmoid	TRIM66	0.28	0.06	enet	29	0.11	1.2e-04	4.85	-5.8	6.3e-09	-0.60	0.07	0.87	FALSE
10	GTEx	Colon Sigmoid	RP11-152H18.3	0.26	0.06	enet	16	0.11	9.3e-05	-4.59	5.7	1.4e-08	0.59	0.13	0.59	FALSE
11	GTEx	Esophagus Mucosa	TRIM66	0.40	0.44	lasso	9	0.47	5.7e-35	-4.56	-5.6	2.3e-08	-0.54	1.00	0.00	FALSE
12	GTEx	Heart Atrial Appendage	TRIM66	0.39	0.31	lasso	9	0.35	2.8e-16	-4.56	-5.7	1.6e-08	-0.56	0.99	0.01	FALSE
13	GTEx	Liver	TRIM66	0.28	0.06	lasso	8	0.13	1.7e-04	7.96	-6.6	3.5e-11	-0.76	0.02	0.92	FALSE
14	GTEx	Lung	TRIM66	0.53	0.38	enet	20	0.44	1.2e-36	-4.56	-5.3	1.4e-07	-0.47	1.00	0.00	FALSE
15	GTEx	Nerve Tibial	TRIM66	0.46	0.39	lasso	6	0.46	2.1e-35	-4.59	-6.0	1.9e-09	-0.59	1.00	0.00	FALSE
16	GTEx	Pancreas	TMEM9B	0.13	0.00	lasso	6	0.00	5.9e-01	2.61	5.3	1.3e-07	0.48	0.06	0.20	FALSE
17	GTEx	Pituitary	TRIM66	0.34	0.07	enet	23	0.13	3.2e-04	-0.83	-5.4	5.9e-08	-0.63	0.02	0.90	FALSE
18	GTEx	Prostate	TRIM66	0.35	0.24	lasso	5	0.30	4.0e-08	-4.55	-5.8	8.2e-09	-0.58	0.14	0.72	FALSE
19	GTEx	Skin Not Sun Exposed Suprapubic	TRIM66	0.21	0.26	enet	11	0.26	8.9e-15	-4.56	-5.5	2.8e-08	-0.56	1.00	0.00	FALSE
20	GTEx	Skin Sun Exposed Lower leg	TRIM66	0.44	0.39	lasso	8	0.39	1.9e-34	-4.56	-5.3	1.0e-07	-0.49	1.00	0.00	FALSE
21	GTEx	Small Intestine Terminal Ileum	TRIM66	0.19	0.15	lasso	3	0.21	1.8e-05	-4.59	-5.5	3.2e-08	-0.53	0.16	0.31	FALSE
22	GTEx	Stomach	TRIM66	0.22	0.20	lasso	5	0.20	8.0e-10	-4.59	-5.2	1.8e-07	-0.47	0.98	0.02	FALSE
23	GTEx	Thyroid	TRIM66	0.49	0.36	enet	23	0.42	1.1e-34	-4.56	-5.6	2.7e-08	-0.59	1.00	0.00	FALSE
24	GTEx	Whole Blood	TRIM66	0.19	0.16	lasso	8	0.15	1.1e-13	-4.56	-5.6	2.1e-08	-0.52	1.00	0.00	FALSE
25	METSIM	Adipose	TRIM66	0.37	0.30	bslmm	520	0.31	8.6e-48	-4.56	-5.8	5.2e-09	-0.55	1.00	0.00	FALSE
26	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIM66	0.24	0.18	enet	9	0.21	1.5e-17	-4.56	-5.8	5.4e-09	-0.56	1.00	0.00	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRIM66	0.14	0.14	lasso	5	0.15	5.8e-29	-4.56	-5.7	1.3e-08	-0.55	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Esophageal Carcinoma	TRIM66	0.21	0.12	enet	33	0.10	3.8e-04	-4.55	-5.5	3.1e-08	-0.43	0.04	0.56	FALSE
29	The Cancer Genome Atlas	Glioblastoma Multiforme	TRIM66	0.27	0.13	blup	56	0.12	1.5e-04	-4.56	-5.5	4.9e-08	-0.59	0.02	0.42	FALSE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RPL27A	0.04	0.01	blup	39	0.02	2.1e-03	4.82	-5.3	1.4e-07	-0.56	0.08	0.09	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TRIM66	0.28	0.25	blup	61	0.25	9.3e-28	-4.56	-5.5	4.2e-08	-0.55	1.00	0.00	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRIM66	0.41	0.31	lasso	6	0.32	3.9e-36	-4.56	-5.2	2.4e-07	-0.46	1.00	0.00	FALSE
33	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TRIM66	0.29	0.16	lasso	8	0.18	1.7e-10	-4.56	-6.8	7.1e-12	-0.74	0.28	0.72	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	STK33	0.09	0.04	blup	121	0.06	1.2e-07	6.50	5.6	1.8e-08	0.59	0.43	0.55	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	TRIM66	0.19	0.18	lasso	5	0.22	9.8e-25	-4.56	-6.6	5.5e-11	-0.70	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TRIM66	0.28	0.18	enet	8	0.20	7.3e-22	-4.56	-5.4	7.4e-08	-0.53	1.00	0.00	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	RPL27A	0.03	0.00	blup	39	0.01	7.5e-02	4.96	-6.6	5.3e-11	-0.69	0.04	0.19	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	TRIM66	0.40	0.30	enet	12	0.32	1.5e-33	-4.59	-5.7	1.0e-08	-0.56	1.00	0.00	FALSE
39	The Cancer Genome Atlas	Soft Tissue Sarcoma	TRIM66	0.28	0.21	lasso	5	0.23	5.4e-14	-4.56	-5.5	2.8e-08	-0.54	1.00	0.00	FALSE
40	The Cancer Genome Atlas	Stomach Adenocarcinoma	TRIM66	0.27	0.12	lasso	5	0.12	2.6e-09	-4.56	-6.6	3.6e-11	-0.68	0.43	0.57	FALSE
41	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ST5	0.41	0.02	blup	128	0.13	2.3e-05	-1.31	5.3	1.1e-07	0.57	0.04	0.38	FALSE
42	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TRIM66	0.28	0.08	blup	61	0.16	2.9e-06	-4.59	-7.1	1.2e-12	-0.80	0.02	0.96	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	STK33	0.14	0.08	lasso	6	0.10	1.0e-09	6.60	-6.4	1.8e-10	-0.70	0.85	0.15	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	TRIM66	0.48	0.49	lasso	9	0.50	4.3e-55	-4.59	-5.5	5.1e-08	-0.50	1.00	0.00	FALSE