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chr11:64,948,277-66,333,072

Best TWAS P=9.14e-09 · Best GWAS P=6.63e-08 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	CTSW	0.30	0.18	lasso	6	0.16	3.9e-13	-5.4	5.2	1.7e-07	-0.99	0.01	0.99	FALSE
2	GTEx	Adipose Visceral Omentum	CTSW	0.22	0.20	lasso	11	0.19	5.1e-10	-5.4	5.2	1.7e-07	-0.99	0.01	0.99	FALSE
3	GTEx	Artery Aorta	CTSW	0.29	0.26	lasso	7	0.25	3.2e-14	-5.4	5.3	1.3e-07	-0.99	0.01	0.99	FALSE
4	GTEx	Breast Mammary Tissue	CTSW	0.25	0.19	lasso	8	0.16	1.3e-08	-5.4	5.4	5.7e-08	-0.99	0.01	0.99	FALSE
5	GTEx	Cells Transformed fibroblasts	FIBP	0.20	0.13	lasso	5	0.17	1.7e-12	-5.4	-5.3	1.1e-07	0.97	0.01	0.99	FALSE
6	GTEx	Esophagus Gastroesophageal Junction	CTSW	0.18	0.15	lasso	2	0.14	1.2e-05	-5.2	5.3	1.0e-07	-0.95	0.01	0.97	FALSE
7	GTEx	Esophagus Mucosa	CTSW	0.32	0.19	lasso	6	0.17	1.3e-11	-5.4	5.3	1.0e-07	-0.99	0.01	0.99	FALSE
8	GTEx	Esophagus Muscularis	CTSW	0.29	0.32	lasso	5	0.32	2.9e-20	-5.4	5.4	6.5e-08	-0.99	0.01	0.99	FALSE
9	GTEx	Lung	CTSW	0.33	0.20	lasso	8	0.21	3.2e-16	-5.4	5.1	2.8e-07	-0.98	0.01	0.99	FALSE
10	GTEx	Nerve Tibial	CTSW	0.22	0.19	lasso	7	0.18	1.3e-12	-5.4	5.2	1.7e-07	-0.99	0.01	0.99	FALSE
11	GTEx	Pancreas	CTSW	0.13	0.11	lasso	3	0.08	4.0e-04	-5.4	5.3	8.7e-08	-0.99	0.01	0.96	FALSE
12	GTEx	Prostate	CTSW	0.29	0.26	lasso	8	0.26	2.9e-07	-5.4	5.5	4.3e-08	-0.99	0.01	0.98	FALSE
13	GTEx	Skin Sun Exposed Lower leg	CTSW	0.19	0.19	lasso	6	0.18	1.1e-14	-5.4	5.4	7.0e-08	-0.99	0.01	0.99	FALSE
14	GTEx	Spleen	CTSW	0.30	0.31	lasso	2	0.26	1.9e-07	-5.4	5.4	8.0e-08	-1.00	0.01	0.99	FALSE
15	GTEx	Stomach	CTSW	0.18	0.20	lasso	7	0.19	1.7e-09	-5.4	5.3	8.9e-08	-1.00	0.01	0.99	FALSE
16	GTEx	Testis	FIBP	0.21	0.22	lasso	5	0.19	6.5e-09	-5.4	-5.3	1.1e-07	0.99	0.01	0.99	FALSE
17	GTEx	Thyroid	CTSW	0.18	0.22	lasso	2	0.21	4.6e-16	-5.4	5.2	1.7e-07	-0.99	0.01	0.99	FALSE
18	METSIM	Adipose	CTSW	0.13	0.12	lasso	10	0.12	3.9e-17	-5.4	5.3	9.6e-08	-0.99	0.01	0.99	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	FIBP	0.13	0.13	lasso	3	0.15	5.8e-19	-5.4	-5.2	2.0e-07	0.95	0.01	0.99	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	CTSW	0.06	0.03	bslmm	328	0.03	3.6e-05	-5.4	5.5	3.9e-08	-0.79	0.01	0.98	FALSE
21	YFS	Blood	CTSW	0.53	0.41	blup	344	0.42	5.5e-149	-5.4	5.3	9.4e-08	-0.96	0.01	0.99	FALSE
22	YFS	Blood	FIBP	0.04	0.02	bslmm	343	0.03	6.4e-09	-5.4	-5.2	2.4e-07	0.82	0.01	0.99	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	CTSW	0.25	0.39	blup	44	0.41	7.3e-91	-5.4	5.2	2.3e-07	-0.98	0.01	0.99	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNX32	0.15	0.17	blup	60	0.17	2.9e-34	-5.1	-5.2	1.7e-07	0.94	0.03	0.97	FALSE
25	The Cancer Genome Atlas	Colon Adenocarcinoma	CTSW	0.40	0.34	enet	14	0.36	4.3e-22	-5.2	5.3	9.0e-08	-0.95	0.01	0.99	FALSE
26	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CTSW	0.31	0.32	lasso	4	0.34	1.8e-39	-5.4	5.3	9.4e-08	-1.00	0.01	0.99	FALSE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CTSW	0.23	0.25	lasso	6	0.25	3.2e-28	-5.4	5.3	8.7e-08	-0.99	0.01	0.99	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SNX32	0.15	0.11	blup	60	0.15	6.0e-17	-5.1	-5.2	1.7e-07	0.90	0.03	0.97	FALSE
29	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CTSW	0.32	0.26	lasso	1	0.26	4.3e-15	-5.4	5.4	7.8e-08	-0.96	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FIBP	0.05	0.01	blup	44	0.02	1.5e-02	-5.1	-5.2	2.6e-07	0.93	0.01	0.76	FALSE
31	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SNX32	0.11	0.06	blup	60	0.09	1.3e-05	-5.4	-5.4	7.7e-08	0.96	0.01	0.99	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	FIBP	0.04	0.04	lasso	3	0.04	1.2e-05	-5.1	-5.2	1.9e-07	0.93	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CTSW	0.63	0.41	lasso	8	0.42	1.2e-21	-5.4	5.4	6.2e-08	-0.98	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Lung Adenocarcinoma	CTSW	0.23	0.29	lasso	7	0.29	1.0e-33	-5.4	5.3	1.1e-07	-1.00	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	SNX32	0.14	0.09	blup	60	0.13	8.8e-15	-5.1	-5.5	4.8e-08	0.93	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CTSW	0.25	0.34	enet	14	0.34	4.1e-40	-5.4	5.3	9.2e-08	-1.00	0.01	0.99	FALSE
37	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CTSW	0.20	0.23	lasso	9	0.23	1.5e-15	-5.4	5.4	6.8e-08	-0.99	0.01	0.99	FALSE
38	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SNX32	0.08	0.10	blup	60	0.11	6.0e-08	-5.1	-5.2	2.4e-07	0.95	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CTSW	0.30	0.23	lasso	11	0.24	1.7e-10	-5.4	5.3	1.1e-07	-0.99	0.01	0.99	FALSE
40	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SNX32	0.30	0.19	lasso	1	0.14	3.9e-06	-5.1	-5.1	2.8e-07	0.91	0.02	0.98	FALSE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	CTSW	0.29	0.49	enet	12	0.49	3.4e-58	-5.4	5.4	7.7e-08	-1.00	0.01	0.99	FALSE
42	The Cancer Genome Atlas	Soft Tissue Sarcoma	CTSW	0.18	0.22	lasso	3	0.22	4.1e-13	-5.4	5.3	8.6e-08	-1.00	0.01	0.99	FALSE
43	The Cancer Genome Atlas	Soft Tissue Sarcoma	FIBP	0.06	0.05	blup	45	0.04	1.2e-03	-5.4	-5.8	9.1e-09	0.97	0.01	0.94	TRUE
44	The Cancer Genome Atlas	Stomach Adenocarcinoma	CTSW	0.24	0.35	lasso	7	0.36	3.0e-27	-5.4	5.2	2.0e-07	-0.96	0.01	0.99	FALSE
45	The Cancer Genome Atlas	Stomach Adenocarcinoma	SNX32	0.12	0.13	blup	60	0.13	1.2e-09	-5.4	-5.5	4.4e-08	0.93	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CTSW	0.26	0.29	lasso	9	0.27	4.7e-10	-5.4	5.2	2.2e-07	-0.99	0.01	0.99	FALSE
47	The Cancer Genome Atlas	Thyroid Carcinoma	CTSW	0.25	0.37	lasso	8	0.37	5.2e-38	-5.4	5.3	1.0e-07	-1.00	0.01	0.99	FALSE
48	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	CTSW	0.24	0.21	enet	21	0.24	2.9e-07	-5.4	5.2	1.6e-07	-0.98	0.01	0.99	FALSE