[Hub]/) : Traits : Age when periods started (menarche) : ← →

chr11:77,027,574-78,979,645

Best TWAS P=1.04e-09 · Best GWAS P=6.74e-10 conditioned to 0.00691

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Aorta GAB2 0.10 0.02 lasso 4 0.02 1.7e-02 5.5 -6.1 1.1e-09 -0.69 0.07 0.68 TRUE
2 GTEx Artery Tibial GAB2 0.06 0.00 lasso 2 0.01 2.4e-02 5.5 -5.4 5.2e-08 -0.81 0.07 0.73 FALSE
3 GTEx Brain Cerebellar Hemisphere USP35 0.19 0.07 enet 13 0.09 2.5e-03 5.0 5.3 1.2e-07 0.78 0.08 0.71 FALSE
4 GTEx Brain Cerebellar Hemisphere NARS2 0.17 0.10 lasso 6 0.10 1.5e-03 4.0 -5.1 2.9e-07 -0.58 0.14 0.62 FALSE
5 GTEx Skin Not Sun Exposed Suprapubic RP11-7I15.3 0.07 0.01 lasso 3 0.02 3.5e-02 5.5 6.1 1.0e-09 0.71 0.06 0.75 FALSE
6 GTEx Skin Sun Exposed Lower leg GAB2 0.06 0.01 enet 26 0.03 2.2e-03 5.5 -5.9 3.7e-09 -0.58 0.09 0.87 FALSE
7 GTEx Testis USP35 0.07 0.06 lasso 2 0.07 6.4e-04 5.5 5.5 3.3e-08 0.81 0.07 0.86 FALSE
8 METSIM Adipose USP35 0.05 0.05 lasso 11 0.04 3.0e-06 5.5 5.6 2.0e-08 0.81 0.07 0.93 FALSE
9 ROSMAP Brain Pre-frontal Cortex GAB2 0.05 0.00 blup 435 0.02 8.0e-04 6.2 -5.4 8.1e-08 -0.65 0.03 0.96 FALSE
10 The Cancer Genome Atlas Glioblastoma Multiforme GAB2 0.10 0.07 blup 100 0.09 8.8e-04 4.7 -5.5 3.7e-08 -0.80 0.05 0.60 FALSE
11 The Cancer Genome Atlas Prostate Adenocarcinoma GAB2 0.06 0.06 blup 100 0.07 7.8e-08 5.5 -5.4 6.4e-08 -0.79 0.09 0.91 FALSE
12 The Cancer Genome Atlas Stomach Adenocarcinoma GAB2 0.04 0.04 blup 100 0.04 1.4e-03 5.0 -5.3 9.4e-08 -0.80 0.08 0.80 FALSE