Best TWAS P=4.84e-17 · Best GWAS P=1.29e-18 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | KIAA1377 | 0.05 | 0.00 | blup | 460 | 0.01 | 6.7e-03 | 1.5 | -5.2 | 2.2e-07 | 0.56 | 0.31 | 0.19 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | KIAA1377 | 0.14 | 0.07 | lasso | 6 | 0.05 | 1.3e-04 | -5.9 | -5.5 | 2.9e-08 | 0.54 | 0.84 | 0.05 | FALSE |
| 3 | GTEx | Colon Sigmoid | TRPC6 | 0.19 | 0.10 | lasso | 3 | 0.05 | 5.6e-03 | -7.9 | -8.4 | 4.8e-17 | 0.97 | 0.02 | 0.93 | TRUE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | TRPC6 | 0.15 | 0.09 | lasso | 5 | 0.09 | 1.9e-05 | -7.0 | -7.1 | 1.3e-12 | 0.72 | 0.04 | 0.89 | FALSE |
| 5 | GTEx | Thyroid | TRPC6 | 0.09 | 0.05 | lasso | 4 | 0.06 | 1.4e-05 | -8.3 | -7.8 | 7.3e-15 | 0.89 | 0.02 | 0.97 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | KIAA1377 | 0.04 | 0.01 | lasso | 3 | 0.01 | 1.4e-02 | 3.5 | -5.3 | 9.6e-08 | 0.38 | 0.01 | 0.82 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | KIAA1377 | 0.11 | 0.02 | lasso | 4 | 0.01 | 4.6e-02 | -5.5 | -5.7 | 9.8e-09 | 0.48 | 0.00 | 0.97 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | TRPC6 | 0.10 | 0.07 | lasso | 3 | 0.07 | 1.3e-08 | 3.4 | -5.3 | 9.3e-08 | 0.67 | 0.94 | 0.05 | FALSE |