Hub : Genes

TRPC6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0750	0.0300	2.6e-03	0.001	0.017	0.017	0.016	-0.001	2.0e-01	3.0e-03	3.2e-03	3.6e-03	4.4e-01
2	GTEx	Colon Sigmoid	0.1910	0.0730	3.1e-03	0.105	NA	-0.005	NA	0.054	1.6e-04	NA	5.5e-01	NA	5.6e-03
3	GTEx	Heart Left Ventricle	0.0880	0.0378	5.3e-03	0.074	NA	0.032	NA	0.053	8.8e-05	NA	8.1e-03	NA	8.0e-04
4	GTEx	Skin Not Sun Exposed Suprapubic	0.1480	0.0510	3.3e-04	0.094	NA	0.079	NA	0.086	8.0e-06	NA	4.1e-05	NA	1.9e-05
5	GTEx	Stomach	0.2060	0.0810	3.3e-03	-0.001	NA	0.013	NA	0.008	3.6e-01	NA	7.4e-02	NA	1.2e-01
6	GTEx	Thyroid	0.0940	0.0350	6.7e-04	0.049	NA	0.057	NA	0.063	1.2e-04	NA	3.5e-05	NA	1.4e-05
7	YFS	Blood	0.0724	0.0177	1.9e-13	0.062	0.047	0.055	0.056	0.057	1.6e-19	5.1e-15	2.2e-17	1.0e-17	6.3e-18
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0644	0.0378	7.9e-03	0.005	0.002	0.001	NA	0.008	7.1e-02	1.6e-01	2.2e-01	NA	4.1e-02
9	TCGA	Brain Lower Grade Glioma	0.1295	0.0391	2.1e-08	0.044	0.061	0.066	NA	0.078	8.9e-06	1.7e-07	5.2e-08	NA	3.2e-09
10	TCGA	Lung Adenocarcinoma	0.0956	0.0419	1.3e-05	0.069	0.048	0.063	NA	0.070	1.6e-08	2.6e-06	7.1e-08	NA	1.3e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.4	2.2	4.6	0.7	-2.1	-0.9	-1.8	-1.1	-2.1	-1.3	-0.4	1.9	-1.5
Bipolar Disorder or Schizophrenia	0.6	1.5	4.1	-0.5	-1.6	-1.0	-1.7	-0.7	-2.0	-1.2	0.7	1.0	-1.0
Depressed Affect (Nagel 2018)	0.5	1.1	4.1	-0.8	1.0	-1.5	0.9	-0.6	0.0	0.5	-0.8	-1.3	2.0
Depression (Nagel 2018)	0.4	0.7	4.4	-0.5	0.2	-0.9	2.1	-0.2	-0.4	-0.3	-0.1	-0.7	0.5
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.7	-0.5	-1.2	0.2	-0.6	-1.3	-1.1	-0.4	1.2	-1.3	-0.7
Neuroticism (Nagel 2018)	0.6	1.4	4.5	0.4	1.2	-0.6	2.1	0.1	0.6	0.8	-0.7	-2.0	1.3
Schizophrenia (2018)	0.2	0.5	1.3	-1.1	-0.3	-0.6	-0.8	-0.1	-0.9	-0.5	1.1	-0.4	-0.0
Schizophrenia vs Biploar Disorder	1.7	2.3	13.4	-1.5	0.7	-0.2	0.2	-0.4	0.9	-0.7	2.3	-3.7	0.4
Worry (Nagel 2018)	0.5	1.0	3.6	1.5	0.8	0.4	1.9	0.4	1.0	0.9	-0.3	-1.0	-0.1
Alzheimer’s Disease (in mother)	0.5	0.6	3.4	-0.2	0.1	-0.1	-0.8	-1.8	0.3	0.9	0.0	-0.8	0.3
Alzheimer’s Disease (in father)	0.7	0.8	1.8	0.9	0.8	1.4	-0.0	1.1	0.8	1.0	-0.7	0.1	0.9
Alzheimer’s Disease (including proxy)	0.6	0.9	2.7	0.3	1.0	0.2	-0.0	-0.8	0.8	1.5	-1.3	0.2	1.6
Crohns Disease (2017)	0.5	1.1	2.1	-1.3	-1.4	-0.4	-1.3	0.8	-1.4	-1.3	0.5	-0.6	-0.7
Irritable Bowel Disease (IBD)	0.3	0.7	3.3	-1.0	-0.9	0.4	0.0	1.8	-0.4	-0.9	0.0	-0.4	-0.5
Ulcerative Colitis (UC)	0.5	0.9	3.3	-0.1	0.3	1.4	1.6	1.8	1.1	0.2	-0.3	-0.1	-0.0
Major Depression (MDD)	0.5	0.6	1.6	-0.5	1.3	-0.1	1.2	-0.7	1.0	0.1	0.1	-1.0	0.4
Reaction Time	0.6	1.2	2.9	0.7	0.9	1.5	0.7	0.5	1.7	1.3	-1.5	-0.3	0.7
Verbal and Numeric Reasoning (VNR)	0.6	1.4	6.7	0.4	-0.5	1.7	-0.6	-0.7	0.2	0.4	1.1	-2.6	-1.3
Breast Cancer	0.5	1.2	3.9	-0.5	1.3	-0.0	1.7	2.0	0.7	-1.4	0.6	-0.5	0.6
Ovarian Cancer	0.3	0.4	1.5	0.4	0.3	-0.8	0.0	0.4	-0.0	0.9	0.3	0.3	1.2
Prostate Cancer	1.9	2.6	7.1	-0.3	2.5	2.5	1.4	-1.2	2.7	0.6	-0.2	-1.3	1.2
Age at First Birth	0.8	1.1	5.3	2.3	0.2	-0.1	0.6	0.0	-0.0	1.0	-1.1	1.7	0.5
Bipolar Disorder (2011)	1.6	1.6	3.7	-1.1	-1.5	-1.0	-1.4	-1.9	-1.8	-1.0	-0.7	0.5	-0.6
Body Mass Index (BMI) (2010)	0.5	0.8	2.4	1.1	1.5	-0.0	1.4	0.1	0.5	0.4	-0.5	-0.9	0.6
Coronary Artery Disease (CAD)	0.4	0.4	1.5	-0.4	-0.5	-0.7	-0.5	0.7	-0.0	-1.2	0.4	0.0	-1.0
Crohns Disease (2012)	0.6	1.0	2.5	-0.9	-1.4	-0.3	-1.6	0.1	-1.1	-1.4	-0.2	0.4	-1.2
Mean Putamen Volume	0.6	0.7	2.5	1.6	0.0	0.3	1.1	0.4	0.4	1.5	0.5	0.3	-0.1
Fasting Glucose	0.9	1.1	2.9	-1.0	0.9	0.6	1.7	-0.4	0.8	0.3	1.3	-1.7	-0.4
HbA1C	0.9	0.9	3.7	0.2	-0.6	-1.9	-0.4	0.2	-1.0	-0.3	-0.5	1.8	0.6
HDL Cholesterol	0.6	1.0	2.9	1.1	1.0	0.7	1.7	-0.3	0.9	1.4	-0.8	-0.6	0.6
LDL Cholesterol	0.7	1.1	4.1	-1.4	0.5	-0.3	-0.3	-0.7	0.9	-1.4	-2.0	-0.7	0.7
Lupus	1.9	2.8	6.5	1.6	2.6	1.5	1.4	0.1	2.4	1.6	-2.2	-0.3	1.4
Neuroticism (2016)	0.7	1.1	4.2	-0.1	0.2	-1.6	-0.1	0.8	-0.1	-0.6	-2.1	0.2	1.7
Primary Biliary Cirrhosis	0.5	0.7	1.9	0.9	-0.0	1.4	0.3	0.8	0.8	-0.8	0.8	-0.4	-1.2
Rheumatoid Arthritis	0.7	1.0	5.0	-0.8	-1.2	-0.4	-2.2	1.2	-1.0	-0.4	0.3	-0.2	-0.3
Schizophrenia (2014)	0.4	0.9	3.4	-1.8	0.0	-0.6	-0.8	-0.5	-0.6	-0.8	1.7	-0.3	-0.1
Triglycerides	0.3	0.5	2.9	-0.1	0.5	-0.4	1.1	0.1	0.9	-1.7	0.1	-0.4	0.3
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.4	0.7	-0.6	-0.4	0.3	-1.2	-0.3	-0.6	0.9	-0.9	-0.2
Ulcerative Colitis	0.3	0.4	1.1	1.0	-0.4	0.8	0.3	0.9	0.4	-0.1	-0.7	0.5	-0.6
Blood Eosinophil Count	0.2	1.3	6.4	0.2	0.7	-2.5	1.0	1.5	-0.0	0.4	-1.2	1.1	0.3
Blood Platelet Count	0.2	2.8	8.4	-1.9	-0.5	-2.9	0.1	-2.4	-0.9	-1.6	-1.8	-1.5	1.3
Blood Red Count	0.4	4.3	13.1	1.6	2.1	2.4	0.8	-1.0	3.5	3.6	-1.5	0.6	0.9
Blood White Count	0.3	2.1	6.8	-0.7	-0.9	-2.6	-2.2	-1.4	-0.3	-0.4	-2.4	-0.3	0.3
Heel T-Score	0.1	0.6	3.2	-0.3	-0.2	0.9	-1.8	0.2	0.6	-0.0	-0.1	1.2	-0.6
BMI	0.1	0.6	2.0	0.5	0.7	-0.7	1.0	1.0	1.4	-0.3	-0.9	0.4	-0.0
Height	0.3	5.5	18.4	4.3	-2.8	-2.1	-1.3	0.5	-2.6	0.7	2.1	2.4	-2.3
Waist Hip Ratio (WHR)	0.6	2.7	5.7	-0.2	-2.4	0.3	-2.4	-0.6	-1.9	-1.6	1.5	1.2	-2.3
Systolic Blood Pressure	0.3	1.6	5.5	-1.0	-0.1	-1.5	-0.6	-2.3	-0.2	2.0	-1.1	-0.0	1.2
Smoking Status	1.2	2.9	5.7	-1.8	-1.6	0.6	-1.0	-0.4	-1.8	-2.4	2.3	-2.3	-1.6
Allergy or Eczema	0.4	0.9	3.3	1.8	-0.6	0.1	0.1	-0.6	-0.3	1.5	1.5	0.7	0.2
Cardiovascular Disease	0.4	1.2	3.8	0.5	1.4	0.1	0.0	-0.8	2.0	1.6	-1.6	-0.0	0.8
Hypothyroidism (self reported)	0.3	0.7	1.9	0.3	-1.1	-1.4	-0.7	-0.5	-1.2	-1.3	0.2	0.0	-0.6
Respiratory disease	0.7	1.5	4.4	-2.1	1.0	0.9	0.7	-1.0	0.8	-1.7	1.1	-1.5	-0.8
Type 2 Diabetes (T2D) (2018)	0.5	1.0	5.1	1.5	0.2	-0.1	-0.2	1.4	-0.1	2.3	0.1	0.8	0.3
Lung FEV1/FVC ratio	0.3	1.7	7.5	-0.3	-1.7	-0.7	-2.7	-1.7	-1.0	0.4	-1.3	-0.5	-0.2
Lung FVC	0.2	1.2	5.5	2.3	-0.9	-0.3	1.2	-0.5	-0.5	0.8	1.1	0.4	-1.3
Neuroticism	0.7	1.7	5.0	0.4	1.3	-0.1	1.8	0.2	1.1	0.9	-1.7	-2.2	1.3
Chronotype (morning person)	0.8	1.9	8.6	1.4	0.5	2.9	0.6	0.6	1.5	-0.9	-0.1	-0.5	-2.0
Hair Pigment	0.0	1.1	5.2	1.4	-1.1	0.6	-0.9	0.7	-0.7	-0.0	0.5	2.3	-0.2
Tanning	0.1	1.0	2.0	-0.6	1.1	-0.0	1.0	0.6	1.1	0.5	-1.2	1.3	1.4
Hand grip strength (left)	1.2	3.0	7.4	1.1	-2.7	-1.0	-2.7	0.5	-1.7	-1.0	1.1	1.7	-2.3
Number of treatments/medications taken	0.7	1.3	3.4	-0.7	1.2	0.5	1.1	-0.5	1.7	1.7	-0.3	-1.8	0.1
Average weekly spirits intake	0.3	0.4	1.6	0.4	0.3	0.9	-0.3	-1.3	0.8	0.7	-0.1	0.1	0.2
Sensitivity / hurt feelings	0.6	1.0	2.0	0.9	0.8	0.5	1.3	-0.4	1.3	1.1	-1.1	-1.4	0.0
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.6	-0.0	0.3	-0.6	1.3	-0.6	-0.5	0.2	-0.3	-1.1	0.7
Hearing difficulty/problems: Yes	1.0	1.6	4.6	-2.1	1.4	-0.2	1.2	-0.2	1.1	-1.4	-0.6	-1.7	1.0
Relative age of first facial hair	1.3	2.7	6.7	-0.1	-2.4	-2.3	-2.0	-1.0	-2.6	-0.3	1.4	1.2	-0.9
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	3.8	-0.5	1.0	0.7	0.7	0.3	0.8	1.3	0.0	-1.9	0.1
Ever used hormone-replacement therapy (HRT)	0.8	1.0	4.9	-2.2	0.4	-0.1	0.8	-0.8	0.3	-0.5	0.6	-1.6	0.3
Ever had hysterectomy (womb removed)	1.3	1.5	3.3	-1.8	1.6	0.7	1.1	1.3	0.9	1.1	-0.3	-0.8	1.6
Systolic blood pressure, automated reading	0.8	2.5	5.9	-2.4	0.8	-1.7	1.2	-2.3	0.2	1.5	-0.6	-1.3	2.0
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	3.0	1.3	-0.0	-0.4	-0.1	1.7	0.1	0.8	-0.4	0.8	-0.1
Angina	0.8	1.1	4.5	-2.1	1.0	0.7	-0.6	0.0	1.3	0.2	-1.1	-0.6	1.3
Medication for hormone replacement therapy	1.7	1.9	5.3	-0.9	-1.4	-0.9	-1.4	0.1	-1.1	-2.3	1.3	1.1	-2.0
Vitamin and mineral supplements	0.6	0.9	2.3	-0.9	-0.6	-1.5	-1.5	0.6	-0.5	-1.2	-0.3	-0.5	-0.7
Supplements: Zinc	0.6	0.7	3.5	1.2	-0.7	0.1	-0.2	-0.1	-0.3	1.9	0.6	0.7	-0.3
Medication: Co-codamol	0.7	0.8	2.6	-0.3	-0.9	-0.8	-1.6	0.8	-1.2	-1.2	-0.0	0.5	-0.7
Medication: Metformin	1.1	1.6	9.0	1.9	0.5	0.6	-0.3	-0.3	0.8	3.0	-0.8	1.0	0.3
Diabetes (father)	0.8	1.0	2.8	1.1	0.4	1.7	-0.4	-1.6	0.4	0.6	1.3	-0.7	-0.3
Diabetes (mother)	1.5	2.0	8.9	1.4	-1.8	-0.7	-1.3	0.4	-1.7	0.0	-0.5	3.0	-0.1
Severe depression (siblings)	0.9	1.0	3.3	1.0	-0.8	0.2	-0.2	0.8	0.1	0.8	-1.6	1.8	-1.2
Pack years adult smoking proportion	0.7	1.1	2.9	0.1	0.8	1.7	-0.1	0.2	1.0	0.9	1.7	-1.6	-0.1
Impedance of leg (right)	0.7	3.3	15.6	-3.9	-0.1	-1.1	-2.1	-1.0	-0.8	-1.4	0.0	-2.8	0.7
Leg fat-free mass (left)	0.5	2.6	16.4	4.1	-0.6	-0.4	0.9	0.2	-0.0	0.6	0.2	2.6	-0.9
Trunk fat percentage	0.1	0.4	1.2	-0.4	0.5	0.0	-0.3	-0.1	1.0	0.7	-1.1	0.1	0.6
Hand grip strength (right)	0.9	2.4	6.1	1.0	-2.5	-0.4	-2.3	-0.0	-1.5	-1.7	1.0	1.1	-2.0
Townsend deprivation index at recruitment	0.2	0.3	1.3	-1.1	-0.5	-0.3	-0.9	-0.1	-0.2	0.4	0.7	-0.2	-0.0
Current tobacco smoking	0.7	1.2	5.1	-1.1	0.6	1.0	0.4	-0.3	0.2	-0.5	1.9	-2.3	0.5
Average weekly fortified wine intake	3.4	4.0	9.7	1.0	3.1	1.8	2.2	0.8	3.0	2.8	-1.1	-0.5	1.7
Maternal smoking around birth	0.6	0.8	3.1	-1.3	0.5	-1.2	-0.3	-1.3	-0.2	0.0	-0.5	0.1	1.8
Fed-up feelings	0.8	1.4	6.3	-0.8	1.6	-0.9	1.0	-0.7	0.2	0.6	-0.8	-1.2	2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.0	-1.4	0.5	-0.0	0.6	-0.1	-0.3	-0.6	0.6	-1.2	0.3
Relative age voice broke	0.6	0.9	2.6	1.0	-0.9	-1.1	0.3	-0.8	-1.3	-0.5	1.6	0.2	-0.6
Taking other prescription medications	1.1	1.8	8.4	-1.2	1.2	1.1	1.2	-0.2	1.7	0.7	0.5	-2.9	-0.1
Age when periods started (menarche)	11.1	26.8	70.4	1.0	-8.4	-2.7	-7.1	-1.6	-7.8	-3.5	3.8	4.5	-5.3
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.9	-1.4	0.3	-0.1	0.3	-0.8	-0.4	0.2	1.3	0.0	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	3.5	-1.8	0.2	-0.1	-1.9	-0.2	0.5	-0.4	-0.6	-0.8	0.5
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.6	0.4	1.8	0.2	1.9	0.6	1.4	0.7	-1.0	-1.0	1.2
Qualifications: CSEs or equivalent	0.3	0.4	1.0	-0.7	-0.5	-0.9	-0.4	0.5	-1.0	-0.3	1.0	-0.3	-0.6
Serious illness, injury or assault to yourself	0.4	0.5	1.9	-0.4	-0.7	0.3	-1.2	0.1	-0.7	0.7	-0.3	1.4	-0.6
High blood pressure	0.2	0.7	2.0	-0.6	-0.3	-0.8	-1.1	-1.3	-0.2	1.4	0.7	0.2	0.3
Hayfever, allergic rhinitis or eczema	0.6	1.4	3.8	1.8	-1.1	-0.7	-0.5	-0.9	-0.6	2.0	-0.1	1.7	0.8
Multivitamins +/- minerals	0.6	0.7	1.9	0.7	0.6	1.2	1.2	-0.4	0.5	0.8	-0.0	0.7	1.4
Stomach or abdominal pain in last month	0.8	1.0	3.5	-1.6	1.1	-0.1	0.8	-0.2	-0.1	0.0	-0.8	-1.0	1.9
Supplements: Glucosamine	0.9	1.2	4.9	1.5	-0.0	1.4	0.7	0.5	-0.3	1.3	2.2	-0.0	0.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	3.5	-0.5	-0.4	-0.5	-0.9	-1.4	-0.5	1.9	0.4	0.5	0.6
Medication: Atenolol	0.4	0.5	1.9	0.9	-0.4	-0.1	-0.9	-1.4	0.3	0.7	0.2	0.0	-0.6
Medication: Levothyroxine sodium	0.4	0.8	2.0	-0.1	-1.0	-1.4	-1.2	-0.1	-1.1	-0.7	-0.3	1.0	-0.6
Sitting height	0.2	1.4	9.6	3.1	-0.6	-0.0	0.3	-0.2	-0.9	0.1	1.2	1.1	-0.6
Chronic bronchitis/emphysema (father)	3.3	3.9	9.9	-2.6	2.3	0.7	1.1	-0.9	2.4	1.3	-2.2	-1.6	3.1
High blood pressure (mother)	0.1	0.2	0.6	-0.3	0.3	-0.1	-0.0	-0.4	0.6	0.6	0.8	0.1	0.6
Body mass index (BMI)	0.2	1.0	3.8	0.1	0.6	-0.7	0.5	0.7	1.1	0.2	-2.0	1.3	1.0
Impedance of leg (left)	0.7	3.2	14.6	-3.8	-0.2	-0.8	-2.3	-0.4	-0.9	-1.2	0.2	-3.0	0.6
Leg predicted mass (left)	0.5	2.6	16.4	4.1	-0.6	-0.2	1.0	0.2	0.0	0.6	0.1	2.6	-0.8
Trunk fat mass	0.0	0.2	0.6	0.5	0.0	-0.4	-0.0	0.2	0.5	0.3	-0.7	0.6	0.0
Waist circumference	0.1	0.5	1.5	0.8	-0.3	-0.5	0.0	1.0	0.1	0.1	-1.0	1.2	0.2
Number of incorrect matches in round	0.3	0.5	1.3	0.7	-0.2	-0.1	0.8	0.9	-0.1	-0.4	-1.1	-0.5	-1.1
Past tobacco smoking	2.0	3.7	7.9	1.9	2.2	1.3	1.5	0.9	2.8	2.7	-1.5	0.8	2.2
Alcohol usually taken with meals	1.5	2.5	10.5	1.3	-1.7	0.3	-1.0	-3.2	-1.6	-1.6	0.6	-0.4	-1.8
Nervous feelings	0.9	1.7	4.6	1.6	1.1	1.4	2.1	-0.4	1.6	0.7	0.1	-1.7	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.7	-0.4	0.6	-0.2	1.1	-0.5	0.1	0.3	-0.4	-1.6	0.5
Hearing difficulty/problems with background noise	0.6	0.9	2.8	-1.4	0.9	-0.5	0.7	1.2	0.2	0.1	0.1	-1.7	1.3
Hair/balding pattern: Pattern 2	1.5	1.9	6.6	0.8	-1.0	0.3	-0.3	-1.7	-0.2	-1.5	2.2	-0.2	-2.6
Had menopause	0.6	0.7	3.4	-1.8	0.6	0.6	1.2	0.4	0.6	0.4	0.4	-0.7	-0.0
Had other major operations	0.6	0.8	1.8	0.3	-1.0	0.9	-1.0	-1.0	-0.8	0.7	1.4	-0.0	-0.8
Forced vital capacity (FVC)	1.4	5.4	21.4	4.6	-3.0	-0.2	-1.1	-0.1	-1.6	-1.1	2.4	1.3	-3.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.7	-0.1	0.4	-0.1	-1.3	0.4	0.8	0.1	-1.0	-0.6	0.5
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	4.9	0.6	2.2	1.2	1.1	-0.2	1.8	1.3	-0.3	-1.6	0.6
Qualifications: None of the above	0.7	1.4	3.4	-1.9	1.2	-0.5	0.1	1.7	1.0	0.9	-0.4	-1.5	1.4
Financial difficulties in last 2 years	0.7	0.9	2.4	-0.3	-0.9	1.4	-0.7	-0.3	-0.1	0.2	1.2	-1.6	-1.3
Mouth/teeth dental problems	0.6	1.0	3.1	1.8	0.9	0.8	1.3	0.5	1.1	-0.2	-0.3	1.1	0.4
Heart attack	2.0	2.5	5.9	-1.1	1.0	-1.5	0.7	-1.5	0.5	2.4	-2.4	-0.4	2.4
Allergy	0.2	0.4	1.9	-0.1	0.5	-0.3	0.6	1.0	-0.2	-1.4	-0.0	-0.1	-0.3
Pain all over the body in last month	0.3	0.3	1.0	0.4	0.1	0.1	0.2	-0.2	0.8	0.8	0.2	-0.7	-1.0
Diabetes (self-reported)	1.5	2.3	11.1	1.7	1.0	1.1	0.4	2.1	1.1	3.3	-0.2	1.0	0.5
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	2.8	1.4	-0.1	-0.5	-0.0	-0.4	-0.5	1.4	-1.6	1.7	1.1
Medication: Ramipril	0.5	0.6	2.1	-1.5	-0.8	-1.1	-0.6	-0.1	-1.1	0.1	0.6	-0.1	0.3
Medication: Simvastatin	0.7	1.0	4.0	-0.4	-0.1	-1.7	-0.4	0.7	-0.1	1.0	-2.0	0.7	0.7
Fluid intelligence score	1.0	2.2	10.3	0.3	-0.0	2.1	-0.1	-0.0	0.7	0.7	2.1	-3.2	-1.2
Illnesses of siblings	1.0	1.4	11.4	0.0	-0.1	-0.6	-0.1	0.3	-0.7	-3.4	-0.9	0.3	0.9
Neuroticism score	0.8	1.7	4.9	0.4	1.5	-0.4	2.2	-0.2	1.3	1.2	-1.4	-1.9	1.1
Weight	0.2	0.8	3.0	1.7	-0.5	-1.1	0.1	0.5	-0.0	-0.0	-0.8	1.7	-0.0
Impedance of arm (right)	0.4	1.8	5.0	-0.8	-0.4	1.7	-2.2	-1.0	-0.3	0.5	1.9	-1.9	-0.8
Arm fat percentage (right)	0.1	0.5	1.3	-0.3	0.7	-0.2	-0.3	0.3	1.0	0.6	-0.9	0.6	1.1
Trunk fat-free mass	0.4	2.3	11.0	3.3	-1.4	-1.4	0.3	0.6	-1.1	-0.6	0.4	2.3	-1.2
Hip circumference	0.2	1.1	2.6	0.9	0.5	-1.3	1.2	1.2	0.4	0.5	-1.6	0.9	1.2
Time employed in main current job	0.3	0.4	0.9	-0.4	0.7	0.7	0.0	-0.6	0.7	0.1	1.0	-0.9	-0.3
Alcohol intake versus 10 years previously	1.1	1.6	5.8	-2.3	-0.4	-0.6	-1.5	-0.4	0.3	-1.4	-0.6	-2.4	-0.0
Father’s age at death	0.6	0.7	3.1	0.3	-0.3	1.5	-0.7	1.8	0.2	0.3	0.4	0.4	-1.1
Worrier / anxious feelings	1.3	2.4	6.8	1.0	1.6	1.5	2.6	0.6	2.3	1.6	-1.3	-1.0	0.8
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	8.4	-0.5	1.7	1.1	1.1	-0.1	1.2	2.2	0.3	-2.9	0.9
Falls in the last year	0.8	1.1	3.9	-0.5	-1.5	-0.5	-2.0	-0.2	-1.7	0.6	0.4	0.9	-0.6
Hair/balding pattern: Pattern 3	0.7	1.1	2.8	-0.8	0.5	-1.7	1.4	0.8	-0.4	0.2	-1.5	0.3	1.5
Number of live births	1.3	1.8	6.1	-0.2	-1.5	-1.2	-2.4	0.7	-0.9	-2.5	-1.0	0.6	-0.5
Forced expiratory volume in 1-second (FEV1)	1.2	3.9	18.8	4.3	-2.5	-0.1	-1.1	-0.6	-1.3	-0.5	1.6	0.9	-2.7
Pulse rate	0.6	1.1	4.0	2.0	0.5	1.0	1.8	1.1	0.0	0.7	-0.8	0.2	0.0
Happiness	0.5	0.7	2.3	1.5	0.1	1.5	0.4	0.1	-0.0	0.3	0.7	0.3	-1.1
Noisy workplace	0.4	0.5	2.1	-0.4	0.7	-0.6	0.1	-0.0	-0.8	-0.4	1.4	-0.5	0.7
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.4	1.6	-0.8	-0.1	-0.1	-1.2	-0.5	0.8	-1.3	0.9	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	2.0	0.7	-0.3	0.0	-0.8	-1.4	-0.1	0.0	-0.1	0.5	-0.2
Mouth/teeth dental problems: Dentures	0.9	1.5	4.0	-2.0	0.6	-1.0	-0.4	-1.1	0.5	1.3	-1.4	-0.8	1.8
Asthma	0.4	0.8	1.7	-1.1	-0.0	1.3	-0.2	-1.3	0.2	0.0	1.2	-0.4	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.6	0.6	0.2	-1.6	0.1	-1.1	-0.6	-1.3	0.1	0.6	0.6
Medication: Cholesterol lowering	0.5	0.8	4.4	0.7	-0.3	-0.6	-0.7	-0.6	0.2	1.0	-2.1	0.7	-0.2
Depression (self-reported)	0.7	0.9	4.5	-2.1	0.6	0.1	0.2	0.1	0.9	0.6	-0.7	-1.5	-0.2
Medication: Lansoprazole	2.3	2.6	7.1	-1.9	2.4	0.9	1.6	-0.2	1.8	0.4	-0.4	-2.7	1.6
Prospective memory result	0.1	0.2	0.4	-0.4	0.2	-0.2	0.7	-0.4	0.5	-0.1	-0.4	0.3	0.6
Lung cancer (father)	2.2	2.5	7.8	0.6	-2.8	-1.1	-1.9	0.1	-2.6	-0.5	0.5	1.3	-1.8
Illnesses of mother	0.4	0.5	2.9	-0.4	-0.1	0.6	0.6	-0.0	-0.3	-1.2	0.3	-1.7	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	14.4	3.8	-2.1	0.0	-0.8	-0.7	-1.2	-0.4	1.1	0.9	-2.1
Pulse wave Arterial Stiffness index	0.1	0.1	0.8	-0.2	0.1	-0.4	0.2	-0.0	-0.1	-0.4	-0.9	0.4	0.2
Impedance of arm (left)	0.4	1.7	4.9	-0.7	-0.1	2.2	-1.9	-1.0	0.3	0.9	1.4	-1.7	-1.0
Arm fat mass (right)	0.1	0.4	1.3	0.4	0.3	-0.6	-0.0	0.3	0.7	0.2	-0.9	1.1	0.7
Trunk predicted mass	0.4	2.4	10.4	3.2	-1.4	-1.4	0.2	0.7	-1.2	-0.6	0.2	2.4	-1.2
Standing height	0.4	3.7	9.9	3.1	-2.5	-0.8	-1.0	-0.5	-2.4	-0.9	2.4	1.1	-2.3
Length of working week for main job	0.7	0.8	1.8	-1.0	-0.0	0.4	-1.3	-1.3	0.5	0.6	-1.1	-0.8	0.9
Exposure to tobacco smoke at home	0.9	1.0	2.9	-1.3	0.1	-1.0	0.2	0.8	-0.8	-0.6	0.9	-1.7	1.3
Breastfed as a baby	0.2	0.3	0.5	0.4	0.4	0.6	0.6	0.6	0.5	0.2	-0.2	0.5	-0.7
Tense / ‘highly strung’	0.1	0.1	0.5	0.1	-0.2	0.7	0.0	-0.4	-0.1	0.5	0.5	-0.0	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	5.4	0.5	-0.1	0.8	-0.5	-1.1	1.0	1.1	0.0	-2.3	-0.3
Hair/balding pattern: Pattern 4	0.2	0.5	1.7	-1.3	-0.5	-0.6	-0.8	-1.0	-0.4	0.2	-0.7	-0.5	0.3
Birth weight of first child	0.7	1.3	3.5	0.8	-1.6	1.0	-0.5	-1.1	-1.3	-1.2	1.1	0.1	-1.9
Peak expiratory flow (PEF)	1.0	2.3	8.3	2.9	-1.9	-1.5	-0.9	-1.1	-1.1	-1.7	-0.0	0.4	-1.3
Pulse wave reflection index	0.6	0.7	1.8	-0.3	1.1	0.1	0.6	0.8	1.2	1.3	-1.1	-0.0	0.4
Ever highly irritable/argumentative for 2 days	4.1	4.9	13.5	2.3	3.1	0.8	3.0	-0.2	2.7	3.7	-0.2	-1.3	1.2
Loud music exposure frequency	1.3	1.4	5.5	0.6	0.6	-1.9	0.0	1.5	-1.0	1.0	-0.0	-0.4	2.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.7	1.3	0.2	0.6	-0.1	0.9	0.6	-0.6	-1.1	0.8	-0.7
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	5.9	-0.3	-2.1	-1.7	-1.5	0.7	-2.4	-1.0	0.1	-0.1	-1.2
Blood clot in the leg (DVT)	0.3	0.4	1.2	-1.1	-0.8	0.2	-0.2	0.9	-0.6	-1.0	0.3	-0.4	-0.2
Medication: Paracetamol	0.4	0.7	1.7	1.0	0.4	-0.1	1.0	1.3	0.1	0.7	0.6	-1.0	-1.1
Headache pain in last month	0.2	0.3	1.7	0.3	-0.0	0.1	0.0	-1.3	-0.4	-0.0	0.7	-0.3	0.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.9	-0.2	-0.8	0.3	-0.1	0.0	-1.3	-1.6	1.7	0.3	-0.2
Glaucoma (self-reported)	0.7	0.9	4.8	0.5	0.6	1.3	0.3	0.7	0.3	2.2	-0.5	0.1	0.7
Gout (self-reported)	0.4	0.5	0.9	0.5	-0.8	-0.9	-0.3	-0.4	-0.9	-0.5	-1.0	0.9	-0.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.3	0.1	-0.9	-1.5	-0.5	-0.7	-1.3	-0.8	-0.5	1.0	-0.0
Medication: Amlodipine	0.4	0.6	1.8	0.4	-0.2	1.4	-1.2	-0.6	-0.1	0.6	1.1	0.7	-0.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.9	-1.4	-0.0	0.7	-0.2	-0.8	-0.0	-0.3	0.6	-0.8	-0.2
Birth weight	0.6	1.3	5.3	0.5	-0.5	2.3	0.2	-0.8	0.1	-1.3	1.0	-1.7	-0.9
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.3	0.5	0.6	-1.5	0.2	1.4	-0.1	-0.3	0.0	1.0	0.4
High blood pressure (siblings)	0.8	1.1	7.1	0.5	0.3	0.1	0.5	-0.4	0.9	2.7	1.2	-0.0	-1.1
Forced vital capacity (FVC), Best measure	1.0	3.5	14.7	3.8	-2.1	0.4	-0.4	-0.1	-1.2	-0.9	2.4	0.8	-2.7
Body fat percentage	0.1	0.5	1.7	-1.0	0.5	-0.5	-0.4	0.2	0.9	0.3	-1.3	0.1	0.9
Leg fat percentage (right)	0.4	1.4	4.4	-2.1	0.4	-1.7	-0.4	0.3	0.6	-0.5	-2.1	0.0	1.4
Arm fat-free mass (right)	0.3	1.4	5.0	2.2	-0.8	-1.2	0.7	0.5	-0.8	-0.8	-0.2	2.2	-0.6
Exposure to tobacco smoke outside home	0.6	0.7	1.8	0.7	1.1	0.6	0.6	0.1	1.2	0.4	-1.1	-0.7	1.3
Comparative body size at age 10	1.2	3.2	11.7	-1.4	1.6	-0.7	3.4	-0.6	1.5	1.2	-1.4	-1.4	2.7
Number of full brothers	0.4	0.5	1.4	-1.0	0.5	-0.2	-0.6	0.9	-0.3	-0.6	0.1	-0.5	1.2
Worry too long after embarrassment	2.4	4.1	13.3	-0.0	2.5	0.3	2.6	0.0	2.7	1.1	-1.3	-3.6	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	5.1	-1.2	-0.2	0.6	-0.0	-1.2	0.4	1.1	-0.3	-2.2	0.1
Wheeze or whistling in the chest in last year	0.4	0.8	4.0	-1.2	0.3	1.1	0.8	-0.1	0.6	0.1	0.3	-2.0	-0.2
Number of children fathered	0.6	0.7	3.4	-0.1	-1.0	-0.5	-0.3	-1.8	-0.7	-1.1	-0.3	-0.4	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	5.1	0.2	0.2	2.2	0.3	2.3	0.1	-1.2	0.0	1.6	-1.3
Age at first live birth	1.1	1.9	6.2	2.5	-1.2	0.6	0.6	2.2	0.0	0.2	-0.1	1.4	-2.0
Pulse wave peak to peak time	0.1	0.1	0.9	0.3	-0.3	0.2	-0.4	0.0	-0.2	0.3	1.0	-0.1	-0.1
Health satisfaction	0.2	0.3	1.2	-0.4	0.3	0.1	0.7	1.1	0.2	-0.5	-0.4	-0.1	0.0
Shortness of breath walking on level ground	3.3	3.9	9.4	-1.1	3.1	1.5	2.9	0.5	2.4	2.1	-0.9	-1.7	1.9
Qualifications: College or University degree	0.7	2.2	8.1	2.2	-1.0	2.3	1.0	-1.0	0.2	-0.1	0.6	0.0	-2.8
Eye problems/disorders: None of the above	1.3	1.5	4.0	0.2	-1.5	-1.2	-1.3	-0.4	-1.9	-2.0	1.3	0.8	-0.4
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.3	-1.5	0.1	-0.8	-0.5	-0.3	-1.1	-1.4	0.3	-0.9	0.8
Emphysema/chronic bronchitis	3.2	3.6	18.4	-2.1	1.9	1.5	0.2	0.1	1.0	1.7	0.3	-4.3	1.7
Medication for pain relief, constipation, heartburn	0.4	0.6	1.3	-0.2	-1.2	1.1	-0.7	0.4	-0.7	-0.8	1.1	0.5	-0.6
Neck or shoulder pain in last month	0.2	0.3	0.6	-0.8	0.6	-0.7	0.2	-0.1	-0.2	0.7	-0.5	-0.1	0.8
Medication: Blood pressure	0.3	0.5	2.3	0.2	0.8	-0.7	0.2	-0.2	0.8	1.5	-0.7	-0.4	0.3
Angina (self-reported)	0.8	1.0	4.3	-2.1	0.8	0.5	-0.7	-0.2	1.1	0.1	-1.1	-0.6	1.3
Migraine (self-reported)	0.6	0.8	2.8	0.1	1.3	-0.1	1.0	-0.1	-0.2	1.2	0.8	-0.6	1.7
Medication: Ibuprofen	0.5	0.6	2.4	0.2	0.1	-1.3	-0.4	-1.0	-0.3	-1.6	-0.3	0.4	0.4
Medication: Allopurinol	1.8	2.4	5.8	0.8	-2.4	-0.9	-1.5	-0.4	-2.3	-1.4	0.7	1.6	-2.0
Medication: Omeprazole	0.9	1.0	4.5	-2.1	0.2	0.4	-0.8	0.3	0.5	0.2	-0.5	-2.0	0.4
Medication: Seretide 50 evohaler	1.8	2.0	7.8	0.4	1.3	0.4	1.5	-1.0	0.4	1.1	2.4	-2.8	0.2
Mean time to correctly identify matches	0.8	1.6	3.6	0.6	1.2	1.7	1.6	0.4	1.9	1.8	-0.9	-0.5	0.6
Heart disease (mother)	0.7	0.8	3.6	-0.7	0.3	0.2	-0.4	1.1	0.5	0.6	-1.9	1.4	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	6.7	-0.2	1.5	-1.1	0.9	0.3	0.9	0.8	-1.7	0.1	2.6
Whole body fat mass	0.1	0.3	1.0	0.3	0.1	-0.6	-0.1	0.4	0.5	0.2	-1.0	0.8	0.4
Leg fat mass (right)	0.2	0.6	2.1	-0.3	0.2	-1.4	0.0	0.3	0.4	-0.5	-1.5	0.8	0.9
Arm predicted mass (right)	0.3	1.6	5.4	2.2	-0.7	-1.6	0.8	0.6	-0.6	-0.6	-0.7	2.3	-0.3
Pulse rate, automated reading	0.6	1.8	4.3	2.0	0.2	2.1	1.9	1.6	0.8	1.4	-0.3	-0.9	-0.5
Alcohol intake frequency.	0.9	2.2	5.7	-0.1	1.7	1.2	1.2	0.9	2.4	2.1	-1.0	-1.8	1.0
Comparative height size at age 10	0.4	2.1	5.4	1.1	1.6	1.9	2.1	-0.7	1.7	0.1	0.1	-2.3	0.6
Number of full sisters	1.4	1.7	4.0	-1.1	-1.4	-2.0	-2.0	-0.1	-1.7	-0.0	-0.9	1.5	0.5
Suffer from ‘nerves’	0.6	0.9	3.9	-0.3	1.0	-0.6	1.2	0.1	1.1	0.0	-2.0	-0.3	1.0
Overall health rating	0.5	1.0	3.4	-1.8	1.0	0.1	0.8	1.2	0.5	0.3	-0.1	-1.6	1.0
Chest pain or discomfort	0.5	0.7	4.3	-0.2	-0.3	0.7	0.5	-0.5	-0.0	0.3	0.9	-2.1	-0.9
Had major operations	0.6	0.7	3.8	-1.5	0.1	-1.9	0.2	-0.1	-0.3	0.3	-0.6	-0.7	0.5
Age at last live birth	1.3	1.9	8.8	3.0	-1.3	0.0	0.0	1.8	0.2	-0.3	-0.9	1.0	-1.9
Family relationship satisfaction	0.7	0.9	5.6	0.8	-0.2	2.4	-0.9	-0.5	0.3	1.0	0.4	0.6	-0.2
Leg pain on walking	2.2	2.7	6.0	0.7	2.4	2.4	2.2	0.4	2.5	1.5	-0.2	-1.6	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	1.0	0.3	0.2	-0.2	0.1	-0.6	-0.2	0.2	1.0	-0.3	0.5
Commuting to job workplace: Car/motor vehicle	1.6	1.8	9.8	-1.8	0.2	-0.7	-0.3	0.0	0.3	-1.7	1.0	-3.1	-0.5
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	6.9	0.4	2.5	0.9	2.6	-0.1	1.9	0.7	-0.4	-1.4	2.1
Medication: Aspirin	1.2	1.6	7.3	-0.0	1.1	-0.5	0.2	1.0	1.7	1.5	-2.7	0.1	0.8
Supplements: Vitamin C	0.7	0.8	2.2	1.5	-1.0	1.1	-0.3	0.3	-0.7	0.7	0.5	1.4	-0.7
Knee pain experienced in last month	1.7	2.7	7.9	1.7	1.7	1.9	0.2	1.3	2.8	2.4	-1.4	-0.5	0.2
Hypertension (Self-reported)	0.3	0.7	2.8	-0.1	0.1	-0.3	-0.9	-1.6	0.2	1.7	0.7	-0.2	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.7	-1.4	0.1	-1.3	-0.4	-1.6	-0.5	-0.5	-0.6	-1.3	0.7
Illnesses of father: Heart disease	0.4	0.5	1.4	-1.2	-0.6	-1.2	-0.1	-0.5	-1.0	0.5	0.1	-0.1	0.6
Illnesses of siblings: Diabetes	1.7	2.1	5.2	0.6	-1.6	0.9	-2.1	1.3	-0.8	1.5	0.9	1.3	-2.3
Smoking status: Previous	2.0	3.0	6.9	-1.1	-2.2	-1.1	-1.5	-0.6	-2.5	-2.6	0.8	-0.2	-2.5
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	4.5	2.1	-1.0	-0.5	-0.8	-0.4	-0.8	-1.1	0.3	1.1	-0.7
Whole body fat-free mass	0.4	2.4	13.8	3.7	-1.0	-0.9	0.7	0.5	-0.7	-0.1	0.2	2.4	-1.0
Leg fat-free mass (right)	0.5	2.9	18.5	4.3	-0.8	-0.1	0.9	0.5	-0.2	0.7	0.5	2.6	-1.1
Arm fat percentage (left)	0.2	0.6	1.8	-0.1	0.8	0.2	-0.1	0.6	1.3	0.8	-1.2	0.6	0.9
Average weekly red wine intake	1.4	2.0	4.9	1.5	-1.9	-1.2	-0.4	-0.2	-2.2	-0.3	2.0	1.0	-1.6
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.9	0.3	-0.8	0.6	-0.0	-0.4	-0.3	0.4	0.2	-0.3	-0.9
Mood swings	0.9	1.6	5.1	0.4	1.3	-0.1	1.5	-0.9	0.4	2.3	-0.9	-1.2	1.9
Loneliness, isolation	0.6	0.8	1.8	0.6	-1.0	-1.3	0.0	1.0	-0.9	-0.2	1.2	-1.0	-0.8
Long-standing illness, disability or infirmity	1.8	2.7	9.8	-3.1	1.4	0.9	1.4	0.6	1.2	0.8	0.5	-3.1	-0.0
Ever had bowel cancer screening	0.7	0.9	3.9	-1.3	0.1	1.1	-0.9	0.4	-0.2	2.0	0.8	-0.2	0.3
Diabetes diagnosed by doctor	1.1	1.8	7.2	1.7	0.7	0.6	0.1	2.1	0.7	2.7	-0.7	1.1	0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	5.2	2.3	-0.8	1.3	-1.5	-0.5	0.3	0.1	-0.2	1.4	-1.0
Friendships satisfaction	2.5	3.1	7.2	1.7	2.0	2.4	0.7	-0.8	2.5	2.7	-1.5	-0.7	1.2
Qualifications: nursing, teaching	0.4	0.6	1.7	1.2	0.4	0.9	1.3	-0.5	0.5	-0.0	-0.2	-0.5	-0.9
Commuting to job workplace: Walk	1.2	1.2	4.3	0.4	1.1	1.4	-0.2	1.2	1.0	0.9	-1.1	2.1	0.6
Eye problems/disorders: Cataract	1.3	1.5	8.1	-2.8	0.2	0.0	-1.2	-0.4	0.2	0.4	-1.2	-1.9	0.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	2.1	-1.2	0.0	-0.5	0.1	-0.1	-0.3	-0.3	1.4	-0.6	-0.2
Medication for cholesterol	0.4	0.7	3.8	2.0	-0.5	0.5	0.3	-0.5	-0.3	-0.5	-0.6	0.2	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.2	1.2	-0.0	-0.9	-0.3	0.8	-0.0	1.5	0.2	-0.9	0.3
Back pain experienced in last month	0.4	0.6	3.0	-1.2	0.5	-0.3	0.2	1.7	0.2	0.1	0.2	-1.0	0.7
Mineral and other dietary supplements	1.6	2.1	9.9	-3.1	0.0	-1.4	-0.8	-1.0	-0.6	-1.6	-1.2	-1.9	0.6
Breast cancer (self-reported)	0.5	0.6	2.8	-1.7	0.1	0.9	-0.2	-0.8	1.0	0.2	-0.4	-0.5	-0.7
Asthma (self-reported)	0.4	0.7	1.6	-1.1	-0.4	1.0	-0.5	-1.2	-0.1	-0.1	1.2	-0.4	-1.3
Osteoporosis (self-reported)	0.6	0.7	1.6	-1.1	-1.0	-0.8	-1.3	0.3	-0.7	0.9	0.2	1.0	-0.7
Osteoarthritis (self-reported)	0.5	0.7	2.5	-0.5	-0.4	-0.8	-1.5	1.6	-0.7	-0.0	-0.3	0.4	0.2
Medication: Aspirin	0.8	1.0	5.1	0.2	0.5	-0.1	-0.3	0.3	1.6	1.4	-2.3	0.2	-0.1
Medication: Gliclazide	0.9	1.1	4.9	1.6	-0.2	0.2	-0.8	0.9	0.1	1.1	-0.3	2.2	-0.8
Illnesses of father: None of the above (group 1)	0.6	0.7	2.2	1.0	-0.9	0.2	-0.6	0.6	-0.5	-0.9	-0.4	1.0	-1.5
Smoking status: Current	0.7	1.1	4.5	-1.2	0.7	0.9	0.2	-0.1	0.2	-0.2	1.8	-2.1	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.3	1.8	0.6	0.6	1.2	-1.1	1.1	1.8	-0.1	-0.3	0.4
Whole body water mass	0.4	2.3	12.7	3.6	-1.1	-1.0	0.7	0.5	-0.8	-0.1	0.3	2.4	-1.1
Leg predicted mass (right)	0.5	2.8	17.7	4.2	-0.8	-0.2	0.9	0.5	-0.3	0.7	0.5	2.5	-1.0
Arm fat mass (left)	0.1	0.4	1.3	0.5	0.2	-0.2	-0.3	0.5	0.7	0.3	-0.9	1.1	0.4
Number of self-reported non-cancer illnesses	0.4	0.8	1.8	-1.3	0.7	-0.2	0.1	-1.1	0.8	1.2	-0.4	-1.3	0.1
Average weekly champagne plus white wine intake	1.2	1.6	5.3	1.8	-0.8	2.3	-0.4	-0.9	0.1	-0.4	-1.4	1.5	-1.3
Miserableness	0.7	1.2	3.4	-1.0	1.6	-0.3	1.2	-0.0	0.7	0.0	-0.8	-1.6	1.8
Guilty feelings	0.8	1.3	5.9	0.7	0.2	-1.5	2.4	0.0	-0.0	0.0	-1.0	-1.7	0.5
Wears glasses or contact lenses	0.3	0.3	1.0	-0.3	-0.4	0.2	0.8	-0.6	-0.4	0.6	1.0	0.0	-0.3
Ever taken oral contraceptive pill	2.0	2.2	6.0	-0.6	-1.3	-2.5	-1.1	-1.0	-2.4	-1.9	-0.4	1.0	0.8
Hearing aid user	0.6	0.6	2.0	-1.4	-0.6	-0.5	-0.6	0.5	-0.6	-1.3	0.6	-0.6	-0.6
Mother’s age at death	0.2	0.3	0.6	-0.4	-0.3	-0.8	0.4	-0.5	-0.5	0.8	-0.6	0.1	0.3
Financial situation satisfaction	0.8	0.9	2.7	-0.8	0.9	1.4	0.5	-0.2	1.4	0.5	-1.1	-1.6	-0.1
Tinnitus: Yes, now most or all of the time	0.5	0.5	1.3	-0.9	0.5	1.1	0.4	-0.7	0.9	-0.5	-0.1	-1.2	-0.0
Commuting to job workplace: Public transport	0.5	0.6	2.9	0.1	-0.7	1.1	-0.9	-0.3	-0.6	-0.2	-0.2	1.7	0.3
Eye problems/disorders: Glaucoma	1.4	1.7	6.2	1.6	0.6	0.8	0.9	2.5	0.5	2.0	-1.0	1.1	0.2
Medication: Blood pressure	0.7	1.4	3.3	-1.2	1.1	1.0	0.1	-1.1	1.2	1.8	1.0	-0.9	1.5
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.8	0.0	-0.9	-1.2	-0.2	0.9	-1.3	-0.5	-0.1	-0.8	-0.6
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.8	1.7	1.0	0.5	1.0	0.7	1.4	1.0	-0.3	0.5	0.4
High cholesterol (Self-reported)	0.3	0.6	2.2	-1.4	-0.2	-1.5	-0.7	-0.4	-0.1	-0.4	-0.9	0.1	-0.2
Medication: Bendroflumethiazide	0.2	0.3	1.1	0.4	-0.2	-0.1	-1.1	-0.9	0.1	0.4	0.5	-0.5	0.1
Medication: Paracetamol	0.4	0.6	1.4	0.8	0.4	-0.4	1.2	0.7	0.5	0.8	-0.0	-1.1	-1.0
Medication: Lisinopril	0.2	0.2	0.5	0.7	0.4	-0.2	0.6	-0.4	0.4	0.7	0.1	-0.1	0.7
Medication: Atorvastatin	0.7	0.8	2.2	0.1	1.4	1.1	0.7	0.6	1.5	1.0	0.1	-0.8	0.5
Illnesses of father: High blood pressure	0.8	1.0	3.1	0.3	0.1	-1.8	0.2	-1.1	-0.7	-1.4	1.5	-0.5	0.5
Alcohol drinker status: Never	0.4	0.5	1.4	1.2	0.4	-0.1	1.0	0.4	0.6	0.6	-0.6	1.1	0.2
Ever smoked	2.2	3.9	8.5	-1.3	-2.4	-0.7	-1.3	-0.6	-2.9	-2.5	2.8	-0.8	-2.3
Basal metabolic rate	0.4	2.0	11.1	3.3	-0.9	-1.0	0.5	0.5	-0.6	-0.1	0.1	2.4	-0.8
Leg fat percentage (left)	0.3	1.1	3.6	-1.9	0.2	-1.4	-0.6	0.6	0.5	-0.4	-1.9	0.1	1.1
Arm fat-free mass (left)	0.3	1.5	5.6	1.9	-0.8	-1.6	0.3	0.9	-0.9	-0.7	-0.5	2.4	-0.2
Number of operations (self-reported)	0.8	1.2	5.5	-2.3	0.3	-0.5	0.1	-0.6	-0.3	1.3	1.5	-1.4	0.6
Average weekly beer plus cider intake	1.9	2.7	12.0	1.8	-0.8	0.5	-0.8	3.5	0.0	-0.6	2.1	0.6	-2.2
Irritability	0.6	1.1	3.2	-0.9	1.4	-0.1	1.4	-0.5	0.2	0.2	-0.2	-1.6	1.8
Risk taking	0.9	1.3	4.2	1.0	0.7	1.6	0.2	-1.4	-0.4	1.6	2.1	0.3	0.4
Ever had prostate specific antigen (PSA) test	1.4	1.7	3.6	0.8	-1.9	-1.1	-1.2	-1.6	-1.6	-0.2	-0.3	1.8	-1.2
Fractured/broken bones in last 5 years	1.1	1.4	4.6	-0.5	-1.4	-0.0	-0.8	-1.5	-1.4	-0.6	2.1	-0.3	-1.3
Age started oral contraceptive pill	0.3	0.4	1.3	-1.1	-0.4	1.0	-0.1	-0.9	-0.1	0.2	0.3	0.2	-0.8
Diastolic blood pressure, automated reading	0.3	1.0	5.3	0.2	0.5	-0.6	0.9	-2.3	0.0	1.4	0.5	-0.7	0.6
Ever depressed for a whole week	0.2	0.2	0.8	0.9	0.0	0.4	0.0	-0.1	0.0	0.8	0.4	-0.6	-0.5
Unable to work because of sickness or disability	0.9	1.2	5.5	-1.6	0.9	0.4	-0.2	-1.2	0.1	0.4	0.9	-2.4	0.8
Commuting to job workplace: Cycle	0.2	0.3	2.0	-0.3	0.4	1.4	0.4	-0.4	0.2	0.3	-0.1	-0.3	-0.3
Myopia	0.9	1.3	5.2	0.1	-1.0	-1.5	-0.9	-0.1	-1.3	-0.1	-1.2	2.3	0.6
Vascular/heart problems diagnosed by doctor	0.5	1.3	4.5	1.3	-0.5	1.0	0.6	1.8	-0.5	-2.1	0.5	0.3	-1.4
Cholesterol lowering medication	0.9	1.4	5.0	-2.2	1.0	-1.3	0.6	0.8	0.7	1.0	-0.2	-1.4	1.3
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	6.7	-2.4	0.7	0.9	-0.6	0.9	0.6	-0.0	-0.3	-2.6	0.6
Pain experienced in last month	0.5	0.8	3.4	-1.1	-0.4	-1.1	-0.2	-1.9	-1.0	-0.5	0.3	0.1	0.9
Supplements: Calcium	1.0	1.1	4.0	-0.2	0.2	1.9	-0.7	1.3	0.8	2.0	1.0	-0.2	0.1
Basal cell carcinoma (self-reported)	0.7	0.8	5.2	-1.2	0.0	-1.0	-0.7	0.1	-0.4	-2.3	0.4	0.0	-0.2
Heart attack/myocardial infarction (self-reported)	2.1	2.7	7.0	-1.1	0.8	-1.8	0.5	-1.4	0.3	2.6	-2.4	-0.1	2.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.6	-1.2	-0.7	0.2	0.1	0.9	-0.4	-1.1	0.4	-0.6	-0.3
Heart disease (siblings)	1.1	1.3	4.1	-2.0	-0.2	-0.7	-1.3	-1.3	-0.6	1.1	-0.7	-0.8	1.5
Alcohol drinker status: Previous	0.7	0.8	2.4	0.5	0.5	0.9	0.7	0.8	1.2	1.3	-1.6	-0.3	-0.1
Pack years of smoking	0.7	1.1	3.0	-0.1	1.1	1.7	0.2	0.2	1.2	1.0	1.3	-1.5	0.2
Impedance of whole body	0.4	2.0	6.3	-2.5	-0.2	0.7	-2.2	-1.0	-0.4	-0.2	0.9	-2.5	-0.1
Leg fat mass (left)	0.1	0.5	1.6	-0.3	0.0	-1.1	-0.2	0.6	0.4	-0.6	-1.3	0.9	0.6
Arm predicted mass (left)	0.3	1.4	4.8	2.0	-0.8	-1.6	0.3	0.8	-0.8	-0.7	-0.4	2.2	-0.3