[Hub]/) : Traits : Age when periods started (menarche) : ← →

chr15:67,138,238-68,789,191

Best TWAS P=1.21e-09 · Best GWAS P=1.91e-09 conditioned to 0.0408

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	MAP2K5	0.14	0.18	lasso	4	0.18	1.0e-14	5.1	-5.2	2.3e-07	-0.78	0.47	0.53	FALSE
2	GTEx	Adipose Visceral Omentum	MAP2K5	0.07	0.08	lasso	3	0.05	1.0e-03	5.2	-5.4	7.5e-08	-0.80	0.06	0.90	FALSE
3	GTEx	Artery Tibial	MAP2K5	0.15	0.18	lasso	3	0.18	6.3e-14	5.0	-5.2	2.3e-07	-0.78	0.48	0.51	FALSE
4	GTEx	Breast Mammary Tissue	MAP2K5	0.14	0.07	lasso	5	0.09	2.8e-05	5.5	-5.8	5.3e-09	-0.88	0.05	0.95	FALSE
5	GTEx	Esophagus Muscularis	MAP2K5	0.24	0.14	lasso	4	0.13	2.1e-08	5.1	-5.2	1.8e-07	-0.78	0.45	0.55	FALSE
6	GTEx	Heart Atrial Appendage	MAP2K5	0.16	0.08	lasso	5	0.16	1.3e-07	5.1	-6.1	1.2e-09	-0.78	0.09	0.90	TRUE
7	GTEx	Heart Left Ventricle	MAP2K5	0.10	0.10	lasso	3	0.10	9.4e-06	5.1	-5.4	8.5e-08	-0.81	0.39	0.57	FALSE
8	GTEx	Muscle Skeletal	MAP2K5	0.08	0.03	lasso	6	0.05	1.9e-05	-5.0	-5.9	3.7e-09	-0.71	0.06	0.94	FALSE
9	GTEx	Ovary	MAP2K5	0.19	0.24	lasso	3	0.21	8.3e-06	5.1	-5.2	1.6e-07	-0.78	0.15	0.65	FALSE
10	GTEx	Skin Sun Exposed Lower leg	MAP2K5	0.13	0.06	lasso	4	0.09	4.4e-08	-4.5	-5.4	5.4e-08	-0.67	0.60	0.40	FALSE
11	GTEx	Thyroid	MAP2K5	0.11	0.16	lasso	4	0.15	9.6e-12	5.1	-5.3	1.1e-07	-0.79	0.46	0.54	FALSE
12	The Cancer Genome Atlas	Glioblastoma Multiforme	IQCH	0.19	0.14	enet	21	0.12	2.4e-04	4.2	-5.3	1.2e-07	-0.59	0.06	0.87	FALSE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAP2K5	0.03	0.03	blup	142	0.02	1.6e-03	5.1	-5.7	1.5e-08	-0.90	0.06	0.90	FALSE
14	The Cancer Genome Atlas	Lung Adenocarcinoma	MAP2K5	0.04	0.04	lasso	3	0.03	8.7e-05	5.1	-5.2	1.9e-07	-0.80	0.13	0.83	FALSE
15	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	IQCH	0.11	0.10	blup	112	0.10	2.3e-07	5.5	-5.6	1.9e-08	-0.60	0.00	1.00	FALSE
16	The Cancer Genome Atlas	Thyroid Carcinoma	IQCH	0.15	0.17	enet	19	0.17	1.3e-16	4.1	-5.2	1.8e-07	-0.50	0.27	0.71	FALSE
17	The Cancer Genome Atlas	Thyroid Carcinoma	MAP2K5	0.10	0.06	lasso	5	0.04	6.1e-05	5.1	-5.4	6.1e-08	-0.83	0.41	0.57	FALSE