Best TWAS P=4.6e-08 · Best GWAS P=1.08e-07 conditioned to 0.478
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellum | FADS3 | 0.26 | 0.18 | lasso | 4 | 0.14 | 5.7e-05 | -5.3 | 5.4 | 6.8e-08 | -0.99 | 0.01 | 0.94 | FALSE |
| 2 | GTEx | Colon Transverse | FADS2 | 0.18 | 0.11 | lasso | 7 | 0.16 | 8.1e-08 | -4.7 | -5.5 | 4.6e-08 | 0.80 | 0.01 | 0.98 | TRUE |
| 3 | GTEx | Pancreas | FADS1 | 0.17 | 0.13 | lasso | 6 | 0.12 | 1.2e-05 | -5.3 | 5.3 | 1.0e-07 | -0.99 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Uterus | PPP1R32 | 0.66 | -0.01 | lasso | 13 | 0.14 | 8.8e-04 | 1.3 | -5.2 | 2.4e-07 | 0.53 | 0.03 | 0.37 | TRUE |
| 5 | YFS | Blood | FADS1 | 0.11 | 0.08 | lasso | 8 | 0.09 | 6.1e-29 | -4.7 | -5.2 | 2.2e-07 | 0.82 | 0.09 | 0.90 | FALSE |
| 6 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FADS1 | 0.06 | 0.03 | lasso | 4 | 0.04 | 7.4e-03 | -5.3 | 5.3 | 1.2e-07 | -0.92 | 0.01 | 0.81 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FADS2 | 0.05 | 0.04 | lasso | 3 | 0.05 | 1.9e-06 | -4.7 | -5.2 | 2.4e-07 | 0.69 | 0.11 | 0.85 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FADS2 | 0.33 | 0.27 | lasso | 9 | 0.35 | 9.3e-21 | -4.7 | -5.3 | 1.3e-07 | 0.80 | 0.08 | 0.91 | FALSE |