Hub : Traits :

Number of live births

17 significantly associated models · 8 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	84767271	86367480	1	1	1.6e-07	1.1e-07	1.00	100	CADM2
2	6	149377610	150823321	1	1	2.8e-07	7.8e-07	0.41	97	PCMT1
3	11	60549966	62346131	4	2	4.6e-08	1.1e-07	0.48	98	FADS2 PPP1R32

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Triglycerides	13.88	2	2	4.4	1	FADS2 PPP1R32
LDL Cholesterol	13.87	2	2	4.4	1	FADS2 PPP1R32
Risk taking	13.31	1	1	2.2	1	CADM2
HDL Cholesterol	12.23	2	2	4.4	1	FADS2 PPP1R32
Blood Platelet Count	12.03	2	2	4.4	1	FADS2 PPP1R32
Number of children fathered	11.74	1	1	2.2	1	CADM2
Pulse rate, automated reading	10.03	2	2	4.4	1	FADS2 PPP1R32
Worrier / anxious feelings	9.91	1	1	2.2	1	CADM2
Past tobacco smoking	9.61	1	1	2.2	1	CADM2
Nervous feelings	9.37	1	1	2.2	1	CADM2
Respiratory disease	9.09	2	2	4.4	1	FADS2 PPP1R32
Worry (Nagel 2018)	9.06	1	1	2.2	1	CADM2
Smoking Status	8.96	1	1	2.2	1	CADM2
Ever smoked	8.75	1	1	2.2	1	CADM2
Smoking status: Previous	8.70	1	1	2.2	1	CADM2
Asthma (self-reported)	8.60	2	1	2.2	1	FADS2 PPP1R32
Asthma	7.97	2	1	2.2	1	FADS2 PPP1R32
Blood Red Count	7.55	3	2	4.4	1	FADS2 PCMT1 PPP1R32
Medication: Levothyroxine sodium	7.20	2	1	2.2	1	FADS2 PPP1R32
Hypothyroidism (self reported)	7.06	2	2	4.4	1	FADS2 PPP1R32
Number of full sisters	6.94	1	1	2.2	1	CADM2
Impedance of arm (left)	6.53	1	1	2.2	1	CADM2
Fasting Glucose	6.52	2	0	0.0	1	FADS2 PPP1R32
Seen doctor (GP) for nerves, anxiety, tension or depression	6.39	3	0	0.0	1	CADM2 FADS2 PPP1R32
Suffer from 'nerves'	6.32	1	1	2.2	1	CADM2
Heel bone mineral density (BMD) T-score, automated (right)	6.23	2	1	2.2	1	FADS2 PPP1R32
Impedance of arm (right)	6.19	1	1	2.2	1	CADM2
Number of full brothers	5.96	2	0	0.0	1	CADM2 PCMT1
Blood Eosinophil Count	5.75	2	2	4.4	1	FADS2 PPP1R32
Osteoporosis (self-reported)	5.65	1	0	0.0	1	FADS2
Bipolar Disorder (2018)	5.63	2	0	0.0	1	CADM2 PPP1R32
Rheumatoid Arthritis	5.63	1	0	0.0	1	FADS2
Hypothyroidism/myxoedema (self-reported)	5.42	2	0	0.0	1	FADS2 PPP1R32
Average weekly beer plus cider intake	5.33	2	0	0.0	1	CADM2 PCMT1
Ever unenthusiastic/disinterested for a whole week	5.28	2	0	0.0	1	FADS2 PPP1R32
Heel bone mineral density (BMD) T-score, automated (left)	5.27	2	1	2.2	1	FADS2 PPP1R32
Comparative body size at age 10	5.24	1	1	2.2	1	CADM2
Impedance of whole body	5.22	1	1	2.2	1	CADM2
Wheeze or whistling in the chest in last year	5.17	2	0	0.0	1	FADS2 PPP1R32
Hand grip strength (left)	5.16	2	1	2.2	1	CADM2 PCMT1
Townsend deprivation index at recruitment	5.16	1	0	0.0	1	PCMT1
Wears glasses or contact lenses	4.81	1	0	0.0	1	CADM2
Arm fat-free mass (left)	4.74	1	1	2.2	1	CADM2
Myopia	4.73	1	0	0.0	1	FADS2
Mouth/teeth dental problems: Loose teeth	4.72	1	0	0.0	1	PCMT1
Average weekly champagne plus white wine intake	4.72	1	0	0.0	1	FADS2
Allergy	4.70	2	0	0.0	1	FADS2 PPP1R32
Arm predicted mass (right)	4.68	1	1	2.2	1	CADM2
Arm predicted mass (left)	4.67	1	1	2.2	1	CADM2
High cholesterol (Self-reported)	4.66	2	0	0.0	1	FADS2 PPP1R32
Tense / 'highly strung'	4.65	2	0	0.0	1	CADM2 PPP1R32
Arm fat-free mass (right)	4.65	1	1	2.2	1	CADM2
Blood White Count	4.53	2	2	4.4	1	FADS2 PPP1R32
Taking other prescription medications	4.42	1	0	0.0	1	FADS2
Pulse rate	4.38	2	0	0.0	1	FADS2 PPP1R32
Gout (self-reported)	4.30	1	0	0.0	1	FADS2
Alcohol drinker status: Never	4.30	1	0	0.0	1	CADM2
Medication: Simvastatin	4.20	2	0	0.0	1	FADS2 PPP1R32
Irritability	4.10	2	0	0.0	1	FADS2 PPP1R32
Crohns Disease (2017)	4.09	2	0	0.0	1	FADS2 PPP1R32
Number of treatments/medications taken	4.07	1	0	0.0	1	FADS2
Qualifications: NVQ or HND or HNC or equivalent	3.94	1	0	0.0	1	FADS2
Commuting to job workplace: Public transport	3.93	1	0	0.0	1	CADM2
Crohns Disease (2012)	3.83	2	0	0.0	1	FADS2 PPP1R32
Supplements: Fish oil (including cod liver oil)	3.77	2	0	0.0	1	FADS2 PPP1R32
Whole body water mass	3.74	1	1	2.2	1	CADM2
Body mass index (BMI)	3.70	1	1	2.2	1	CADM2
Whole body fat-free mass	3.69	1	1	2.2	1	CADM2
Basal metabolic rate	3.69	1	1	2.2	1	CADM2
Ever had stillbirth, spontaneous miscarriage or termination	3.68	1	0	0.0	1	CADM2
Trunk fat-free mass	3.67	1	1	2.2	1	CADM2
Trunk predicted mass	3.64	1	1	2.2	1	CADM2
Hair/balding pattern: Pattern 4	3.59	2	0	0.0	1	FADS2 PPP1R32
Number of self-reported non-cancer illnesses	3.49	1	0	0.0	1	FADS2
Vitamin and mineral supplements	3.48	1	0	0.0	1	FADS2
Seen a psychiatrist for nerves, anxiety, tension or depression	3.48	1	0	0.0	1	FADS2
Mouth/teeth dental problems: Mouth ulcers	3.46	1	0	0.0	1	CADM2
Hand grip strength (right)	3.39	2	0	0.0	1	CADM2 PCMT1
Leg fat mass (left)	3.36	1	1	2.2	1	CADM2
Leg fat mass (right)	3.30	1	1	2.2	1	CADM2
Qualifications: nursing, teaching	3.24	1	0	0.0	1	CADM2
Pain type(s) experienced in last month: Hip pain	3.20	1	0	0.0	1	PCMT1
Leg fat-free mass (left)	3.09	1	1	2.2	1	CADM2
Leg predicted mass (left)	3.07	1	1	2.2	1	CADM2
Weight	3.07	1	1	2.2	1	CADM2
Heel T-Score	3.05	3	2	4.4	1	FADS2 PCMT1 PPP1R32
Medication: Allopurinol	3.04	1	0	0.0	1	FADS2
Worry too long after embarrassment	3.03	1	0	0.0	1	CADM2
Leg fat-free mass (right)	3.02	1	1	2.2	1	CADM2
Age started oral contraceptive pill	3.02	1	0	0.0	1	CADM2
Leg predicted mass (right)	3.00	1	1	2.2	1	CADM2
Neuroticism	2.99	1	0	0.0	1	CADM2
Migraine (self-reported)	2.95	1	0	0.0	1	CADM2
BMI	2.93	1	1	2.2	1	CADM2
Alcohol intake frequency.	2.93	1	0	0.0	1	CADM2
Headache pain in last month	2.81	1	0	0.0	1	FADS2
Impedance of leg (right)	2.72	1	1	2.2	1	CADM2
Maternal smoking around birth	2.70	1	0	0.0	1	FADS2
Impedance of leg (left)	2.70	1	1	2.2	1	CADM2
Verbal and Numeric Reasoning (VNR)	2.66	1	0	0.0	1	FADS2
Waist circumference	2.65	1	1	2.2	1	CADM2
Qualifications: College or University degree	2.58	1	1	2.2	1	CADM2
Smoking status: Current	2.54	1	0	0.0	1	CADM2
Arm fat mass (left)	2.52	1	1	2.2	1	CADM2
Chronotype (morning person)	2.49	1	0	0.0	1	PPP1R32
Neuroticism score	2.42	1	0	0.0	1	CADM2
Arm fat mass (right)	2.40	1	1	2.2	1	CADM2
Leg fat percentage (right)	2.39	1	0	0.0	1	CADM2
Financial situation satisfaction	2.39	1	0	0.0	1	CADM2
Leg fat percentage (left)	2.31	1	0	0.0	1	CADM2
Knee pain experienced in last month	2.26	1	0	0.0	1	PCMT1
Tanning	2.24	2	1	2.2	1	CADM2 FADS2
Qualifications: O levels/GCSEs or equivalent	2.20	1	0	0.0	1	CADM2
Neuroticism (Nagel 2018)	2.13	1	0	0.0	1	CADM2
Hip circumference	2.11	1	1	2.2	1	CADM2
Whole body fat mass	1.99	1	1	2.2	1	CADM2
Systolic Blood Pressure	1.98	1	1	2.2	1	CADM2
Sensitivity / hurt feelings	1.94	1	0	0.0	1	PCMT1
Fluid intelligence score	1.93	1	0	0.0	1	FADS2
Qualifications: A levels/AS levels or equivalent	1.93	1	0	0.0	1	CADM2
Forced expiratory volume in 1-second (FEV1), predicted	1.88	1	0	0.0	1	FADS2
Intelligence (Savage-Jansen 2018)	1.80	1	0	0.0	1	FADS2
Current tobacco smoking	1.79	1	0	0.0	1	CADM2
Age at first live birth	1.70	1	0	0.0	1	PCMT1
Systolic blood pressure, automated reading	1.55	1	0	0.0	1	CADM2
Forced expiratory volume in 1-second (FEV1)	1.36	1	0	0.0	1	FADS2
Forced vital capacity (FVC)	1.26	1	0	0.0	1	FADS2
Trunk fat mass	1.21	1	0	0.0	1	CADM2
Arm fat percentage (right)	1.10	1	0	0.0	1	CADM2
Standing height	0.99	1	1	2.2	1	FADS2
Arm fat percentage (left)	0.99	1	0	0.0	1	CADM2
Body fat percentage	0.97	1	0	0.0	1	CADM2
Sitting height	0.74	1	0	0.0	1	FADS2
Hair Pigment	0.72	1	1	2.2	1	FADS2
Lung FVC	0.68	1	0	0.0	1	PCMT1
Height	0.62	1	1	2.2	1	FADS2

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Uterus	1	0.176	1.7
GTEx	Artery Coronary	0	0.000	1.6
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.6
GTEx	Brain Cerebellum	1	0.050	1.6
GTEx	Colon Sigmoid	0	0.000	1.6
GTEx	Heart Atrial Appendage	0	0.000	1.6
GTEx	Ovary	0	0.000	1.6
GTEx	Small Intestine Terminal Ileum	0	0.000	1.6
GTEx	Brain Caudate basal ganglia	0	0.000	1.5
GTEx	Brain Cortex	0	0.000	1.5
GTEx	Brain Frontal Cortex BA9	0	0.000	1.5
GTEx	Brain Hypothalamus	0	0.000	1.5
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.5
GTEx	Breast Mammary Tissue	0	0.000	1.5
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.5
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.5
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.5
GTEx	Heart Left Ventricle	0	0.000	1.5
GTEx	Lung	1	0.035	1.5
GTEx	Pancreas	1	0.061	1.5
GTEx	Pituitary	0	0.000	1.5
GTEx	Prostate	0	0.000	1.5
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.5
GTEx	Spleen	0	0.000	1.5
GTEx	Stomach	0	0.000	1.5
GTEx	Thyroid	0	0.000	1.5
GTEx	Vagina	0	0.000	1.5
GTEx	Whole Blood	0	0.000	1.5
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	1	0.091	1.5
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.5
GTEx	Adipose Subcutaneous	0	0.000	1.4
GTEx	Adipose Visceral Omentum	0	0.000	1.4
GTEx	Adrenal Gland	0	0.000	1.4
GTEx	Artery Aorta	0	0.000	1.4
GTEx	Artery Tibial	1	0.027	1.4
GTEx	Brain Hippocampus	0	0.000	1.4
GTEx	Brain Putamen basal ganglia	0	0.000	1.4
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.4
GTEx	Cells Transformed fibroblasts	0	0.000	1.4
GTEx	Colon Transverse	1	0.048	1.4
GTEx	Esophagus Mucosa	0	0.000	1.4
GTEx	Esophagus Muscularis	0	0.000	1.4
GTEx	Liver	0	0.000	1.4
GTEx	Muscle Skeletal	0	0.000	1.4
GTEx	Nerve Tibial	0	0.000	1.4
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.4
GTEx	Testis	0	0.000	1.4
NTR	Blood	1	0.042	1.4
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.4
YFS	Blood	3	0.065	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	1	0.023	1.4
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.4
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.037	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	1	0.049	1.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.4
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.4
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.4
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.4
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.4
METSIM	Adipose	1	0.022	1.3
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.3