TWAS hub - FADS3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.2590	0.0890	0.0032	0.179	NA	0.076	NA	0.142	5.5e-06	NA	0.003	NA	5.7e-05
2	METSIM	Adipose	0.0441	0.0195	0.0043	0.013	0.005	0.017	0.009	0.014	4.0e-03	0.059	0.001	0.014	3.0e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Triglycerides	37.1	60.8	106.1	-10.3	-3.9
HDL Cholesterol	28.6	47.7	91.7	9.6	1.9
LDL Cholesterol	27.3	43.2	86.4	9.3	0.1
Pulse rate, automated reading	24.6	79.4	158.8	-12.6	0.3
Blood Platelet Count	20.5	237.7	475.2	-21.8	-0.3
Fasting Glucose	18.3	21.9	41.5	6.4	-1.5
Blood Red Count	14.4	138.8	265.7	-16.3	-3.5
Pulse rate	14.3	24.2	47.6	-6.9	0.9
Respiratory disease	12.6	28.0	55.9	7.5	0.2
Asthma (self-reported)	10.5	20.9	41.7	6.5	-0.0
Number of live births	10.3	14.6	29.1	5.4	0.1
Asthma	9.5	18.8	37.6	6.1	-0.2
Average weekly champagne plus white wine intake	9.2	12.6	24.7	-5.0	-0.7
Schizophrenia vs Biploar Disorder	8.9	11.7	12.2	3.5	3.3
Blood Eosinophil Count	8.6	66.1	132.2	11.5	0.0
Hypothyroidism (self reported)	8.6	19.7	39.1	6.3	-0.6
Medication: Levothyroxine sodium	8.2	13.8	27.1	5.2	0.8
Irritability	7.6	12.8	20.1	-4.5	-2.3
Bipolar Disorder (2018)	7.5	11.8	14.9	-3.9	-2.9
Crohns Disease (2012)	7.1	11.5	22.9	-4.8	-0.2
Deep venous thrombosis (DVT) (self-reported)	6.7	8.6	14.4	3.8	1.7
Blood White Count	6.6	49.2	98.2	9.9	0.4
Blood clot in the leg (DVT)	6.6	8.6	14.7	3.8	1.6
Hypothyroidism/myxoedema (self-reported)	6.3	12.3	23.5	4.8	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	6.2	8.1	16.2	-4.0	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	6.1	14.0	28.0	-5.3	0.1
Qualifications: NVQ or HND or HNC or equivalent	5.8	7.0	10.5	3.2	1.9
Commuting to job workplace: Car/motor vehicle	5.7	6.5	8.6	2.9	-2.1
Bipolar Disorder (2011)	5.6	5.4	9.4	-3.1	-1.2
Hair/balding pattern: Pattern 4	5.6	13.6	26.0	5.1	1.1
Crohns Disease (2017)	5.4	11.8	23.5	-4.8	-0.0
Number of treatments/medications taken	5.4	9.7	16.6	4.1	1.6
Allergy	5.4	12.5	23.0	-4.8	-1.4
Exposure to tobacco smoke at home	5.4	6.0	12.0	3.5	0.1
Supplements: Fish oil (including cod liver oil)	5.4	7.1	14.1	3.8	-0.1
Type 2 Diabetes (T2D) (2012)	5.0	5.7	10.4	3.2	1.1
Vitamin and mineral supplements	5.0	6.7	11.3	-3.4	-1.5
Wheeze or whistling in the chest in last year	5.0	9.0	17.4	4.2	0.8
Verbal and Numeric Reasoning (VNR)	4.6	11.0	18.8	-4.3	-1.8
Rheumatoid Arthritis	4.5	6.2	10.4	3.2	1.4
Forced expiratory volume in 1-second (FEV1), predicted	4.5	9.4	17.3	4.2	1.3
Heel T-Score	4.4	34.7	66.1	-8.1	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	4.4	9.9	19.8	-4.5	-0.2
Multivitamins +/- minerals	4.4	5.6	8.0	2.8	1.8
Medication: Simvastatin	4.4	6.5	13.1	3.6	0.0
Medication: Ibuprofen	4.4	5.3	8.8	3.0	1.3
Miserableness	4.4	7.6	12.8	-3.6	-1.6
Taking other prescription medications	4.3	6.6	10.8	3.3	1.5
High cholesterol (Self-reported)	4.2	7.4	14.6	3.8	-0.4
Fractured/broken bones in last 5 years	4.2	5.4	10.6	3.2	0.5
Mineral and other dietary supplements	4.0	5.4	10.8	-3.3	0.1
Commuting to job workplace: Public transport	4.0	4.8	6.5	-2.5	1.8
Ever unenthusiastic/disinterested for a whole week	3.8	4.6	9.2	-3.0	-0.2
Medication: Ibuprofen (e.g. Nurofen)	3.8	4.8	8.0	2.8	1.3
Myopia	3.8	5.6	11.0	-3.3	-0.3
Heart attack/myocardial infarction (self-reported)	3.8	4.9	8.5	2.9	1.2
Basal cell carcinoma (self-reported)	3.6	4.2	6.0	2.4	1.6
Fluid intelligence score	3.5	7.3	12.9	-3.6	-1.3
Falls in the last year	3.5	4.8	9.6	3.1	-0.0
Cholesterol lowering medication	3.4	5.0	9.6	3.1	-0.6
Average weekly spirits intake	3.3	4.1	5.3	2.3	-1.7
Number of children fathered	3.3	3.7	4.8	2.2	-1.6
Intelligence (Savage-Jansen 2018)	3.2	9.8	16.2	-4.0	-1.8
Had other major operations	3.2	3.9	7.0	-2.6	-0.8
Number of self-reported non-cancer illnesses	3.2	5.6	11.2	3.3	-0.0
Irritable Bowel Disease (IBD)	3.1	7.3	14.7	-3.8	-0.2
Lupus	3.1	4.6	6.7	2.6	1.6
Heart attack	3.1	4.0	6.5	2.6	1.2
Medication: Seretide 50 evohaler	3.1	3.6	6.6	2.6	0.7
Major Depression (MDD)	3.0	3.6	4.8	-2.2	-1.5
Other serious medical condition/disability diagnosed by doctor	3.0	3.9	6.6	2.6	1.1
Townsend deprivation index at recruitment	3.0	4.3	8.1	-2.9	-0.6
Osteoporosis (self-reported)	3.0	3.8	6.3	2.5	-1.1
Bipolar Disorder or Schizophrenia	2.9	7.0	11.8	-3.4	-1.5
Medication for pain relief, constipation, heartburn	2.9	4.9	6.1	-2.5	-2.0
Medication: Allopurinol	2.9	3.9	7.3	-2.7	0.7
Long-standing illness, disability or infirmity	2.9	4.4	8.3	2.9	0.7
Standing height	2.8	27.6	53.0	7.3	-1.5
Mouth/teeth dental problems: Bleeding gums	2.8	3.7	5.4	-2.3	-1.4
Headache pain in last month	2.8	4.7	9.4	3.1	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.7	4.2	8.4	-2.9	-0.0
Family relationship satisfaction	2.6	3.2	5.5	-2.3	-0.9
Ovarian Cancer	2.5	3.3	5.2	2.3	1.2
Commuting to job workplace: Cycle	2.5	3.0	3.4	-1.8	1.6
Height	2.4	46.8	92.7	9.6	-0.9
Maternal smoking around birth	2.4	3.4	5.8	2.4	-1.0
Gout (self-reported)	2.4	3.3	5.8	-2.4	0.9
Medication: Ventolin 100micrograms inhaler	2.3	3.0	6.0	2.5	0.1
Leg fat percentage (right)	2.3	8.4	13.8	-3.7	-1.8
Exposure to tobacco smoke outside home	2.3	3.1	6.1	2.5	-0.3
Diastolic blood pressure, automated reading	2.2	6.7	12.6	-3.5	0.9
Emphysema/chronic bronchitis	2.1	2.4	3.7	1.0	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.4	4.7	2.2	-0.4
HbA1C	2.0	2.2	4.5	2.1	-0.1
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	4.2	2.0	-0.2
Had major operations	2.0	2.3	4.3	-2.1	-0.6
Hearing aid user	2.0	2.3	4.2	2.0	0.6
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	3.9	-0.9	2.0
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	4.9	2.2	0.3
Heart disease (mother)	1.9	2.3	4.6	-0.0	2.1
Mouth/teeth dental problems: Mouth ulcers	1.9	3.1	6.1	-2.5	0.2
Medication: Lisinopril	1.9	2.4	3.9	-2.0	1.0
Ever depressed for a whole week	1.9	2.4	4.7	-2.2	-0.2
Chronotype (morning person)	1.8	4.1	7.3	2.7	0.9
Body mass index (BMI)	1.8	7.8	12.0	-3.5	-1.9
Had menopause	1.8	2.3	3.6	-1.0	-1.9
Worry too long after embarrassment	1.8	3.0	4.5	2.1	-1.2
Leg fat percentage (left)	1.8	6.5	11.4	-3.4	-1.2
Sitting height	1.7	12.0	20.1	4.5	-2.0
Arm fat percentage (right)	1.7	6.8	9.4	-3.1	-2.0
Forced expiratory volume in 1-second (FEV1)	1.7	5.7	11.4	3.4	0.1
Pulse wave Arterial Stiffness index	1.7	1.9	2.9	-1.0	-1.7
Pulse wave reflection index	1.7	2.1	2.7	1.6	-1.2
Medication: Paracetamol	1.7	2.6	4.3	2.1	0.9
Allergy or Eczema	1.6	4.2	7.3	2.7	1.0
Fed-up feelings	1.6	2.8	3.2	-1.6	-1.8
Serious illness, injury or assault to yourself	1.6	1.9	2.1	1.3	1.4
Hair/balding pattern: Pattern 3	1.6	2.4	4.7	2.2	0.1
Pulse wave peak to peak time	1.6	1.9	2.3	1.2	1.5
Supplements: Calcium	1.6	1.8	3.5	1.9	-0.3
Medication: Paracetamol	1.5	2.5	3.8	2.0	1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	2.1	-1.4	1.2
Shortness of breath walking on level ground	1.5	1.8	1.9	1.3	-1.4
Medication: Omeprazole	1.5	1.7	2.6	-0.9	1.6
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	2.6	-1.6	-1.1
Ulcerative Colitis	1.4	2.0	4.0	-2.0	0.2
Medication for hormone replacement therapy	1.4	1.5	2.8	1.7	-0.5
Hayfever, allergic rhinitis or eczema	1.4	3.1	4.4	2.1	1.4
Stomach or abdominal pain in last month	1.4	1.7	2.1	1.2	1.5
Reaction Time	1.3	2.5	4.8	-0.4	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.8	3.3	-1.8	-0.4
Chronic bronchitis/emphysema (father)	1.3	1.6	3.0	1.7	0.5
Past tobacco smoking	1.3	2.4	3.2	-1.8	1.2
Depression (self-reported)	1.3	1.6	2.8	-1.7	0.7
Mean time to correctly identify matches	1.3	2.4	2.7	-1.7	1.5
Arm fat percentage (left)	1.3	5.2	6.6	-2.6	-1.9
Friendships satisfaction	1.3	1.6	2.7	0.8	-1.6
Wears glasses or contact lenses	1.3	1.5	2.3	-1.5	0.8
Waist Hip Ratio (WHR)	1.2	5.5	11.0	3.3	-0.1
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	3.6	-0.3	-1.9
Mouth/teeth dental problems	1.2	1.9	3.3	1.8	-0.7
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.8	-1.7	-0.4
Body fat percentage	1.2	4.6	6.3	-2.5	-1.7
Migraine (self-reported)	1.2	1.5	2.3	0.9	-1.5
Comparative height size at age 10	1.2	6.5	11.2	3.3	-1.4
Smoking status: Previous	1.2	1.8	2.0	1.4	-1.3
Commuting to job workplace: Walk	1.2	1.3	1.6	-1.3	1.0
Eye problems/disorders: Cataract	1.2	1.3	2.6	1.6	0.3
Illnesses of father: None of the above (group 1)	1.2	1.5	1.7	-1.1	-1.3
Age at First Birth	1.1	1.6	2.9	-1.7	-0.5
Type 2 Diabetes (T2D) (2018)	1.1	2.0	2.2	1.4	-1.5
Qualifications: CSEs or equivalent	1.1	1.5	2.8	1.7	-0.4
Forced vital capacity (FVC)	1.1	4.3	8.6	2.9	-0.1
Financial difficulties in last 2 years	1.1	1.5	2.4	0.8	1.6
Medication: Ramipril	1.1	1.4	2.8	-1.7	-0.2
Time employed in main current job	1.1	1.2	2.4	0.0	-1.6
Medication: Cholesterol lowering	1.1	1.7	3.3	1.8	0.2
Prospective memory result	1.1	1.4	1.9	1.4	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	6.0	2.5	0.9
Arm fat mass (right)	1.1	4.6	4.6	-2.1	-2.1
Leg fat mass (right)	1.1	4.1	4.8	-2.2	-1.8
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.1	1.5	0.8
Ever smoked	1.1	1.9	2.1	1.3	-1.5
Neuroticism (2016)	1.0	1.4	2.0	-0.9	-1.4
Schizophrenia (2014)	1.0	2.1	4.3	-2.1	0.2
Supplements: Glucosamine	1.0	1.2	1.9	1.4	-0.7
Medication: Atenolol	1.0	1.2	2.4	-1.5	0.2
Peak expiratory flow (PEF)	1.0	2.4	3.7	1.0	-1.9
Leg pain on walking	1.0	1.3	2.2	1.5	0.6
Arm fat mass (left)	1.0	4.1	4.7	-1.9	-2.2
Age started oral contraceptive pill	1.0	1.2	1.3	-1.1	-1.1
Leg fat mass (left)	1.0	3.7	4.4	-2.1	-1.8
Sensitivity / hurt feelings	0.9	1.5	1.8	1.3	-1.1
High blood pressure	0.9	2.6	4.7	-2.2	-0.7
Neuroticism score	0.9	1.9	2.4	-1.2	-1.5
Father’s age at death	0.9	1.2	2.1	-1.4	0.5
Overall health rating	0.9	1.9	2.7	1.6	-1.1
Age at last live birth	0.9	1.4	1.4	1.2	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.3	1.1	0.8
Medication for cholesterol	0.9	1.4	2.6	-1.6	0.5
Ever taken oral contraceptive pill	0.9	0.9	1.6	1.3	-0.5
Mother’s age at death	0.9	1.2	1.9	-1.4	-0.7
Depression (Nagel 2018)	0.8	1.2	1.3	-1.1	1.1
Trunk fat percentage	0.8	3.2	3.4	-1.7	-1.9
Trunk fat-free mass	0.8	4.4	6.5	2.5	-1.5
Happiness	0.8	1.0	1.3	-0.8	-1.2
Length of working week for main job	0.8	0.8	1.7	1.3	-0.2
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.6	-1.3	0.5
Whole body fat mass	0.8	3.2	4.0	-1.5	-2.0
Guilty feelings	0.8	1.1	2.2	-0.2	-1.5
Alcohol drinker status: Never	0.8	0.9	1.7	-0.3	1.3
Vascular/heart problems diagnosed by doctor	0.8	2.1	3.9	2.0	0.5
Ulcerative Colitis (UC)	0.7	1.4	2.2	-1.5	-0.8
Breast Cancer	0.7	1.6	2.4	-0.9	1.6
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.5	1.2	-0.5
Leg fat-free mass (left)	0.7	3.7	5.3	1.4	-2.3
Hip circumference	0.7	2.9	3.7	-1.4	-1.9
Trunk predicted mass	0.7	4.1	6.2	2.5	-1.5
Forced vital capacity (FVC), Best measure	0.7	2.7	4.6	2.1	0.9
Age at first live birth	0.7	1.3	1.6	1.0	1.3
Health satisfaction	0.7	0.8	1.0	0.8	-1.0
Supplements: Vitamin C	0.7	0.8	1.5	1.2	0.4
Illnesses of father: Heart disease	0.7	1.0	1.3	0.8	1.1
Back pain experienced in last month	0.7	1.0	1.3	1.2	-0.8
Financial situation satisfaction	0.7	0.9	1.3	1.1	-0.7
Alcohol drinker status: Previous	0.7	0.8	1.5	-0.4	-1.2
Depressed Affect (Nagel 2018)	0.6	1.3	2.2	-1.5	-0.6
Alzheimer’s Disease (in father)	0.6	0.6	1.1	-1.1	-0.3
Lung FVC	0.6	3.2	3.4	-1.9	1.7
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.0	-1.0	0.7
Supplements: Zinc	0.6	0.6	0.7	0.7	0.9
Severe depression (siblings)	0.6	0.7	1.3	0.2	1.1
Leg predicted mass (left)	0.6	3.4	4.6	1.5	-2.2
Hearing difficulty/problems with background noise	0.6	1.0	1.2	-0.9	-1.1
Weight	0.6	2.7	5.5	-0.0	-2.3
Mouth/teeth dental problems: Dentures	0.6	1.0	1.8	0.4	1.4
Impedance of arm (left)	0.6	2.8	5.6	2.4	0.1
Eye problems/disorders: None of the above	0.6	0.7	1.2	-1.1	-0.5
Mouth/teeth dental problems: Loose teeth	0.6	0.7	0.8	-0.9	0.8
Number of full sisters	0.6	0.8	1.3	-0.6	-1.1
Whole body fat-free mass	0.6	3.5	4.2	2.0	-1.7
Leg fat-free mass (right)	0.6	3.3	3.6	1.9	-1.7
Mood swings	0.6	1.1	1.3	-1.2	-1.0
Medication: Aspirin	0.6	0.8	1.1	0.7	1.1
Whole body water mass	0.6	3.5	4.1	2.0	-1.7
Leg predicted mass (right)	0.6	3.3	3.6	1.9	-1.7
Tinnitus: Yes, now most or all of the time	0.6	0.7	0.7	-0.9	0.9
Illnesses of father: High blood pressure	0.6	0.7	1.4	1.2	-0.3
Schizophrenia (2018)	0.5	1.0	1.7	-1.3	0.5
Body Mass Index (BMI) (2010)	0.5	0.7	1.2	-0.3	1.1
Lung FEV1/FVC ratio	0.5	2.4	4.5	2.1	-0.5
Medication: Co-codamol	0.5	0.5	0.9	0.9	-0.4
Medication: Metformin	0.5	0.8	1.2	-1.1	-0.6
Diabetes (father)	0.5	0.6	1.1	1.0	0.3
Diabetes (mother)	0.5	0.6	0.9	0.9	-0.6
Impedance of leg (left)	0.5	2.4	2.6	1.5	1.6
Trunk fat mass	0.5	2.3	3.9	-0.9	-2.0
Medication: Amlodipine	0.5	0.7	1.0	-0.7	1.0
Arm predicted mass (right)	0.5	2.4	3.6	1.9	-1.1
Hypertension (Self-reported)	0.5	1.3	2.7	-1.6	-0.1
Medication: Gliclazide	0.5	0.5	1.1	-0.2	-1.0
Basal metabolic rate	0.5	3.0	3.6	1.6	-1.9
Average weekly beer plus cider intake	0.5	0.7	1.3	-1.1	-0.4
Impedance of whole body	0.5	2.4	4.4	2.1	0.6
Mean Putamen Volume	0.4	0.4	0.8	-0.3	0.9
BMI	0.4	2.5	3.5	-1.9	-1.2
Hair Pigment	0.4	11.2	20.6	-4.5	1.3
Hearing difficulty/problems: Yes	0.4	0.6	0.9	-1.0	0.5
Angina	0.4	0.6	0.9	0.9	-0.5
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.4	-0.6	0.7
Worrier / anxious feelings	0.4	0.8	1.6	-0.1	-1.3
Birth weight	0.4	1.0	1.5	-0.7	-1.2
Arm fat-free mass (right)	0.4	2.2	2.4	1.6	-1.4
Chest pain or discomfort	0.4	0.6	1.0	1.0	-0.4
Medication: Blood pressure	0.4	0.7	1.1	-1.0	-0.5
Arm fat-free mass (left)	0.4	1.9	2.9	1.0	-1.7
Pain experienced in last month	0.4	0.7	1.4	-0.2	-1.2
Neuroticism (Nagel 2018)	0.3	0.7	0.9	-0.6	-1.0
Systolic Blood Pressure	0.3	1.3	1.6	1.3	1.0
Neuroticism	0.3	0.8	0.9	-0.8	-1.0
Relative age of first facial hair	0.3	0.5	1.0	-1.0	-0.2
Current tobacco smoking	0.3	0.6	1.0	-0.4	1.0
High blood pressure (mother)	0.3	0.4	0.7	0.8	-0.1
Number of incorrect matches in round	0.3	0.5	0.7	-0.6	-0.8
Qualifications: None of the above	0.3	0.7	1.3	0.1	-1.1
Lung cancer (father)	0.3	0.3	0.5	-0.7	-0.4
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	0.5	-0.6	0.7
Comparative body size at age 10	0.3	0.8	1.2	-1.1	0.6
Neck or shoulder pain in last month	0.3	0.5	0.9	0.9	0.2
Angina (self-reported)	0.3	0.4	0.5	0.7	-0.4
Loneliness, isolation	0.3	0.4	0.7	0.0	-0.8
Smoking status: Current	0.3	0.6	1.1	-0.2	1.0
Heart disease (siblings)	0.3	0.3	0.3	0.6	-0.6
Arm predicted mass (left)	0.3	1.8	2.3	1.1	-1.5
Alzheimer’s Disease (in mother)	0.2	0.3	0.5	0.7	0.2
Prostate Cancer	0.2	0.3	0.3	-0.5	-0.5
Primary Biliary Cirrhosis	0.2	0.2	0.3	-0.6	-0.3
Cardiovascular Disease	0.2	0.7	1.0	1.0	0.6
Tanning	0.2	2.4	4.6	2.1	0.3
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	-0.5	0.4
Pack years adult smoking proportion	0.2	0.3	0.6	-0.2	-0.8
Impedance of leg (right)	0.2	1.1	1.1	1.0	1.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.3	0.6	0.4
Waist circumference	0.2	0.7	1.3	-0.3	-1.2
Hair/balding pattern: Pattern 2	0.2	0.3	0.4	0.6	-0.4
Illnesses of siblings	0.2	0.3	0.7	0.8	0.0
Impedance of arm (right)	0.2	1.1	2.2	1.5	0.1
Noisy workplace	0.2	0.2	0.4	0.7	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	-0.1	-0.6
Medication: Lansoprazole	0.2	0.2	0.3	0.4	-0.5
Breastfed as a baby	0.2	0.2	0.4	0.2	-0.6
Tense / ‘highly strung’	0.2	0.3	0.4	-0.7	0.4
Loud music exposure frequency	0.2	0.2	0.3	-0.6	0.4
Glaucoma (self-reported)	0.2	0.3	0.5	0.7	0.2
Number of full brothers	0.2	0.3	0.4	-0.4	-0.6
Alcohol intake frequency.	0.2	0.4	0.6	0.4	-0.8
Suffer from ‘nerves’	0.2	0.3	0.5	0.7	0.4
Medication: Aspirin	0.2	0.3	0.5	0.4	0.7
Knee pain experienced in last month	0.2	0.3	0.6	0.2	0.8
Average weekly red wine intake	0.2	0.3	0.6	-0.3	-0.7
Qualifications: nursing, teaching	0.2	0.3	0.6	-0.8	0.2
Medication: Bendroflumethiazide	0.2	0.3	0.5	0.1	-0.7
Pack years of smoking	0.2	0.3	0.5	-0.4	-0.7
Worry (Nagel 2018)	0.1	0.1	0.3	0.1	-0.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	0.3	-0.3
Nervous feelings	0.1	0.1	0.1	0.3	0.3
Pain all over the body in last month	0.1	0.1	0.1	-0.2	-0.3
Alcohol intake versus 10 years previously	0.1	0.2	0.3	0.6	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.3	0.0	-0.6
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.2	0.3	0.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	-0.7	0.0
High blood pressure (siblings)	0.1	0.2	0.4	-0.6	0.1
Qualifications: College or University degree	0.1	0.3	0.5	-0.7	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.3	-0.2	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	0.3	0.3
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.4	0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.1	0.4	-0.4
Ever had bowel cancer screening	0.1	0.1	0.1	0.4	-0.4
Diabetes diagnosed by doctor	0.1	0.2	0.4	0.6	-0.3
Breast cancer (self-reported)	0.1	0.1	0.2	-0.4	0.2
Osteoarthritis (self-reported)	0.1	0.1	0.1	-0.0	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	-0.6	0.3
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.4	0.3
Medication: Atorvastatin	0.1	0.1	0.2	-0.1	-0.4
Number of operations (self-reported)	0.1	0.2	0.4	0.0	-0.6
Risk taking	0.1	0.1	0.1	0.3	0.3
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	0.2	0.3
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.5	0.1
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	0.2	-0.2
Coronary Artery Disease (CAD)	0.0	0.0	0.0	-0.2	-0.0
Smoking Status	0.0	0.1	0.1	-0.3	-0.4
Hand grip strength (left)	0.0	0.1	0.2	0.4	-0.1
Systolic blood pressure, automated reading	0.0	0.1	0.2	0.0	0.5
Hand grip strength (right)	0.0	0.1	0.2	-0.0	0.4
Average weekly fortified wine intake	0.0	0.1	0.1	0.3	-0.2
Relative age voice broke	0.0	0.1	0.1	-0.3	-0.2
Age when periods started (menarche)	0.0	0.1	0.1	0.3	0.3
Alcohol usually taken with meals	0.0	0.0	0.0	-0.0	0.2
Diabetes (self-reported)	0.0	0.1	0.1	0.1	-0.4
Illnesses of mother	0.0	0.0	0.0	-0.2	-0.1
Birth weight of first child	0.0	0.0	0.0	-0.2	-0.2
Medication: Blood pressure	0.0	0.1	0.1	-0.1	-0.4

Hub : Genes

FADS3

Models

Trait associations