Hub : Genes

FADS3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.2590 0.0890 0.0032 0.179 NA 0.076 NA 0.142 5.5e-06 NA 0.003 NA 5.7e-05
2 METSIM Adipose 0.0441 0.0195 0.0043 0.013 0.005 0.017 0.009 0.014 4.0e-03 0.059 0.001 0.014 3.0e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 7.5 11.8 14.9 -3.9 -2.9
Bipolar Disorder or Schizophrenia 2.9 7.0 11.8 -3.4 -1.5
Depressed Affect (Nagel 2018) 0.6 1.3 2.2 -1.5 -0.6
Depression (Nagel 2018) 0.8 1.2 1.3 -1.1 1.1
Intelligence (Savage-Jansen 2018) 3.2 9.8 16.2 -4.0 -1.8
Neuroticism (Nagel 2018) 0.3 0.7 0.9 -0.6 -1.0
Schizophrenia (2018) 0.5 1.0 1.7 -1.3 0.5
Schizophrenia vs Biploar Disorder 8.9 11.7 12.2 3.5 3.3
Worry (Nagel 2018) 0.1 0.1 0.3 0.1 -0.5
Alzheimer’s Disease (in mother) 0.2 0.3 0.5 0.7 0.2
Alzheimer’s Disease (in father) 0.6 0.6 1.1 -1.1 -0.3
Alzheimer’s Disease (including proxy) 0.0 0.0 0.1 0.2 -0.2
Crohns Disease (2017) 5.4 11.8 23.5 -4.8 -0.0
Irritable Bowel Disease (IBD) 3.1 7.3 14.7 -3.8 -0.2
Ulcerative Colitis (UC) 0.7 1.4 2.2 -1.5 -0.8
Major Depression (MDD) 3.0 3.6 4.8 -2.2 -1.5
Reaction Time 1.3 2.5 4.8 -0.4 2.2
Verbal and Numeric Reasoning (VNR) 4.6 11.0 18.8 -4.3 -1.8
Breast Cancer 0.7 1.6 2.4 -0.9 1.6
Ovarian Cancer 2.5 3.3 5.2 2.3 1.2
Prostate Cancer 0.2 0.3 0.3 -0.5 -0.5
Age at First Birth 1.1 1.6 2.9 -1.7 -0.5
Bipolar Disorder (2011) 5.6 5.4 9.4 -3.1 -1.2
Body Mass Index (BMI) (2010) 0.5 0.7 1.2 -0.3 1.1
Coronary Artery Disease (CAD) 0.0 0.0 0.0 -0.2 -0.0
Crohns Disease (2012) 7.1 11.5 22.9 -4.8 -0.2
Mean Putamen Volume 0.4 0.4 0.8 -0.3 0.9
Fasting Glucose 18.3 21.9 41.5 6.4 -1.5
HbA1C 2.0 2.2 4.5 2.1 -0.1
HDL Cholesterol 28.6 47.7 91.7 9.6 1.9
LDL Cholesterol 27.3 43.2 86.4 9.3 0.1
Lupus 3.1 4.6 6.7 2.6 1.6
Neuroticism (2016) 1.0 1.4 2.0 -0.9 -1.4
Primary Biliary Cirrhosis 0.2 0.2 0.3 -0.6 -0.3
Rheumatoid Arthritis 4.5 6.2 10.4 3.2 1.4
Schizophrenia (2014) 1.0 2.1 4.3 -2.1 0.2
Triglycerides 37.1 60.8 106.1 -10.3 -3.9
Type 2 Diabetes (T2D) (2012) 5.0 5.7 10.4 3.2 1.1
Ulcerative Colitis 1.4 2.0 4.0 -2.0 0.2
Blood Eosinophil Count 8.6 66.1 132.2 11.5 0.0
Blood Platelet Count 20.5 237.7 475.2 -21.8 -0.3
Blood Red Count 14.4 138.8 265.7 -16.3 -3.5
Blood White Count 6.6 49.2 98.2 9.9 0.4
Heel T-Score 4.4 34.7 66.1 -8.1 -1.8
BMI 0.4 2.5 3.5 -1.9 -1.2
Height 2.4 46.8 92.7 9.6 -0.9
Waist Hip Ratio (WHR) 1.2 5.5 11.0 3.3 -0.1
Systolic Blood Pressure 0.3 1.3 1.6 1.3 1.0
Smoking Status 0.0 0.1 0.1 -0.3 -0.4
Allergy or Eczema 1.6 4.2 7.3 2.7 1.0
Cardiovascular Disease 0.2 0.7 1.0 1.0 0.6
Hypothyroidism (self reported) 8.6 19.7 39.1 6.3 -0.6
Respiratory disease 12.6 28.0 55.9 7.5 0.2
Type 2 Diabetes (T2D) (2018) 1.1 2.0 2.2 1.4 -1.5
Lung FEV1/FVC ratio 0.5 2.4 4.5 2.1 -0.5
Lung FVC 0.6 3.2 3.4 -1.9 1.7
Neuroticism 0.3 0.8 0.9 -0.8 -1.0
Chronotype (morning person) 1.8 4.1 7.3 2.7 0.9
Hair Pigment 0.4 11.2 20.6 -4.5 1.3
Tanning 0.2 2.4 4.6 2.1 0.3
Hand grip strength (left) 0.0 0.1 0.2 0.4 -0.1
Number of treatments/medications taken 5.4 9.7 16.6 4.1 1.6
Average weekly spirits intake 3.3 4.1 5.3 2.3 -1.7
Sensitivity / hurt feelings 0.9 1.5 1.8 1.3 -1.1
Frequency of depressed mood in last 2 weeks 0.6 0.8 1.0 -1.0 0.7
Hearing difficulty/problems: Yes 0.4 0.6 0.9 -1.0 0.5
Relative age of first facial hair 0.3 0.5 1.0 -1.0 -0.2
Other serious medical condition/disability diagnosed by doctor 3.0 3.9 6.6 2.6 1.1
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.5 1.2 -0.5
Ever had hysterectomy (womb removed) 0.2 0.2 0.3 -0.5 0.4
Systolic blood pressure, automated reading 0.0 0.1 0.2 0.0 0.5
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.1 0.3 -0.3
Angina 0.4 0.6 0.9 0.9 -0.5
Medication for hormone replacement therapy 1.4 1.5 2.8 1.7 -0.5
Vitamin and mineral supplements 5.0 6.7 11.3 -3.4 -1.5
Supplements: Zinc 0.6 0.6 0.7 0.7 0.9
Medication: Co-codamol 0.5 0.5 0.9 0.9 -0.4
Medication: Metformin 0.5 0.8 1.2 -1.1 -0.6
Diabetes (father) 0.5 0.6 1.1 1.0 0.3
Diabetes (mother) 0.5 0.6 0.9 0.9 -0.6
Severe depression (siblings) 0.6 0.7 1.3 0.2 1.1
Pack years adult smoking proportion 0.2 0.3 0.6 -0.2 -0.8
Impedance of leg (right) 0.2 1.1 1.1 1.0 1.0
Leg fat-free mass (left) 0.7 3.7 5.3 1.4 -2.3
Trunk fat percentage 0.8 3.2 3.4 -1.7 -1.9
Hand grip strength (right) 0.0 0.1 0.2 -0.0 0.4
Townsend deprivation index at recruitment 3.0 4.3 8.1 -2.9 -0.6
Current tobacco smoking 0.3 0.6 1.0 -0.4 1.0
Average weekly fortified wine intake 0.0 0.1 0.1 0.3 -0.2
Maternal smoking around birth 2.4 3.4 5.8 2.4 -1.0
Fed-up feelings 1.6 2.8 3.2 -1.6 -1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.8 3.3 -1.8 -0.4
Relative age voice broke 0.0 0.1 0.1 -0.3 -0.2
Taking other prescription medications 4.3 6.6 10.8 3.3 1.5
Age when periods started (menarche) 0.0 0.1 0.1 0.3 0.3
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 0.4 -0.6 0.7
Heel bone mineral density (BMD) T-score, automated (left) 4.4 9.9 19.8 -4.5 -0.2
Tinnitus: Yes, but not now, but have in the past 2.0 2.1 4.2 2.0 -0.2
Qualifications: CSEs or equivalent 1.1 1.5 2.8 1.7 -0.4
Serious illness, injury or assault to yourself 1.6 1.9 2.1 1.3 1.4
High blood pressure 0.9 2.6 4.7 -2.2 -0.7
Hayfever, allergic rhinitis or eczema 1.4 3.1 4.4 2.1 1.4
Multivitamins +/- minerals 4.4 5.6 8.0 2.8 1.8
Stomach or abdominal pain in last month 1.4 1.7 2.1 1.2 1.5
Supplements: Glucosamine 1.0 1.2 1.9 1.4 -0.7
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.3 0.6 0.4
Medication: Atenolol 1.0 1.2 2.4 -1.5 0.2
Medication: Levothyroxine sodium 8.2 13.8 27.1 5.2 0.8
Sitting height 1.7 12.0 20.1 4.5 -2.0
Chronic bronchitis/emphysema (father) 1.3 1.6 3.0 1.7 0.5
High blood pressure (mother) 0.3 0.4 0.7 0.8 -0.1
Body mass index (BMI) 1.8 7.8 12.0 -3.5 -1.9
Impedance of leg (left) 0.5 2.4 2.6 1.5 1.6
Leg predicted mass (left) 0.6 3.4 4.6 1.5 -2.2
Trunk fat mass 0.5 2.3 3.9 -0.9 -2.0
Waist circumference 0.2 0.7 1.3 -0.3 -1.2
Number of incorrect matches in round 0.3 0.5 0.7 -0.6 -0.8
Past tobacco smoking 1.3 2.4 3.2 -1.8 1.2
Alcohol usually taken with meals 0.0 0.0 0.0 -0.0 0.2
Nervous feelings 0.1 0.1 0.1 0.3 0.3
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.9 3.6 -0.3 -1.9
Hearing difficulty/problems with background noise 0.6 1.0 1.2 -0.9 -1.1
Hair/balding pattern: Pattern 2 0.2 0.3 0.4 0.6 -0.4
Had menopause 1.8 2.3 3.6 -1.0 -1.9
Had other major operations 3.2 3.9 7.0 -2.6 -0.8
Forced vital capacity (FVC) 1.1 4.3 8.6 2.9 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 6.1 14.0 28.0 -5.3 0.1
Ever unenthusiastic/disinterested for a whole week 3.8 4.6 9.2 -3.0 -0.2
Qualifications: None of the above 0.3 0.7 1.3 0.1 -1.1
Financial difficulties in last 2 years 1.1 1.5 2.4 0.8 1.6
Mouth/teeth dental problems 1.2 1.9 3.3 1.8 -0.7
Heart attack 3.1 4.0 6.5 2.6 1.2
Allergy 5.4 12.5 23.0 -4.8 -1.4
Pain all over the body in last month 0.1 0.1 0.1 -0.2 -0.3
Diabetes (self-reported) 0.0 0.1 0.1 0.1 -0.4
Hayfever/allergic rhinitis (self-reported) 1.9 2.5 4.9 2.2 0.3
Medication: Ramipril 1.1 1.4 2.8 -1.7 -0.2
Medication: Simvastatin 4.4 6.5 13.1 3.6 0.0
Fluid intelligence score 3.5 7.3 12.9 -3.6 -1.3
Illnesses of siblings 0.2 0.3 0.7 0.8 0.0
Neuroticism score 0.9 1.9 2.4 -1.2 -1.5
Weight 0.6 2.7 5.5 -0.0 -2.3
Impedance of arm (right) 0.2 1.1 2.2 1.5 0.1
Arm fat percentage (right) 1.7 6.8 9.4 -3.1 -2.0
Trunk fat-free mass 0.8 4.4 6.5 2.5 -1.5
Hip circumference 0.7 2.9 3.7 -1.4 -1.9
Time employed in main current job 1.1 1.2 2.4 0.0 -1.6
Alcohol intake versus 10 years previously 0.1 0.2 0.3 0.6 0.1
Father’s age at death 0.9 1.2 2.1 -1.4 0.5
Worrier / anxious feelings 0.4 0.8 1.6 -0.1 -1.3
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.3 0.0 -0.6
Falls in the last year 3.5 4.8 9.6 3.1 -0.0
Hair/balding pattern: Pattern 3 1.6 2.4 4.7 2.2 0.1
Number of live births 10.3 14.6 29.1 5.4 0.1
Forced expiratory volume in 1-second (FEV1) 1.7 5.7 11.4 3.4 0.1
Pulse rate 14.3 24.2 47.6 -6.9 0.9
Happiness 0.8 1.0 1.3 -0.8 -1.2
Noisy workplace 0.2 0.2 0.4 0.7 0.1
Qualifications: A levels/AS levels or equivalent 0.1 0.1 0.2 0.3 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.4 -0.1 -0.6
Mouth/teeth dental problems: Dentures 0.6 1.0 1.8 0.4 1.4
Asthma 9.5 18.8 37.6 6.1 -0.2
Medication: Ibuprofen (e.g. Nurofen) 3.8 4.8 8.0 2.8 1.3
Medication: Cholesterol lowering 1.1 1.7 3.3 1.8 0.2
Depression (self-reported) 1.3 1.6 2.8 -1.7 0.7
Medication: Lansoprazole 0.2 0.2 0.3 0.4 -0.5
Prospective memory result 1.1 1.4 1.9 1.4 -0.9
Lung cancer (father) 0.3 0.3 0.5 -0.7 -0.4
Illnesses of mother 0.0 0.0 0.0 -0.2 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.4 6.0 2.5 0.9
Pulse wave Arterial Stiffness index 1.7 1.9 2.9 -1.0 -1.7
Impedance of arm (left) 0.6 2.8 5.6 2.4 0.1
Arm fat mass (right) 1.1 4.6 4.6 -2.1 -2.1
Trunk predicted mass 0.7 4.1 6.2 2.5 -1.5
Standing height 2.8 27.6 53.0 7.3 -1.5
Length of working week for main job 0.8 0.8 1.7 1.3 -0.2
Exposure to tobacco smoke at home 5.4 6.0 12.0 3.5 0.1
Breastfed as a baby 0.2 0.2 0.4 0.2 -0.6
Tense / ‘highly strung’ 0.2 0.3 0.4 -0.7 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 2.7 4.2 8.4 -2.9 -0.0
Hair/balding pattern: Pattern 4 5.6 13.6 26.0 5.1 1.1
Birth weight of first child 0.0 0.0 0.0 -0.2 -0.2
Peak expiratory flow (PEF) 1.0 2.4 3.7 1.0 -1.9
Pulse wave reflection index 1.7 2.1 2.7 1.6 -1.2
Ever highly irritable/argumentative for 2 days 1.2 1.4 2.8 -1.7 -0.4
Loud music exposure frequency 0.2 0.2 0.3 -0.6 0.4
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.5 -0.7 0.0
Mouth/teeth dental problems: Bleeding gums 2.8 3.7 5.4 -2.3 -1.4
Blood clot in the leg (DVT) 6.6 8.6 14.7 3.8 1.6
Medication: Paracetamol 1.5 2.5 3.8 2.0 1.1
Headache pain in last month 2.8 4.7 9.4 3.1 -0.2
Medication for cholesterol, blood pressure or diabetes 0.3 0.4 0.5 -0.6 0.7
Glaucoma (self-reported) 0.2 0.3 0.5 0.7 0.2
Gout (self-reported) 2.4 3.3 5.8 -2.4 0.9
Hypothyroidism/myxoedema (self-reported) 6.3 12.3 23.5 4.8 -1.0
Medication: Amlodipine 0.5 0.7 1.0 -0.7 1.0
Medication: Ventolin 100micrograms inhaler 2.3 3.0 6.0 2.5 0.1
Birth weight 0.4 1.0 1.5 -0.7 -1.2
Chronic bronchitis/emphysema (mother) 0.8 0.9 1.6 -1.3 0.5
High blood pressure (siblings) 0.1 0.2 0.4 -0.6 0.1
Forced vital capacity (FVC), Best measure 0.7 2.7 4.6 2.1 0.9
Body fat percentage 1.2 4.6 6.3 -2.5 -1.7
Leg fat percentage (right) 2.3 8.4 13.8 -3.7 -1.8
Arm fat-free mass (right) 0.4 2.2 2.4 1.6 -1.4
Exposure to tobacco smoke outside home 2.3 3.1 6.1 2.5 -0.3
Comparative body size at age 10 0.3 0.8 1.2 -1.1 0.6
Number of full brothers 0.2 0.3 0.4 -0.4 -0.6
Worry too long after embarrassment 1.8 3.0 4.5 2.1 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 6.2 8.1 16.2 -4.0 -0.0
Wheeze or whistling in the chest in last year 5.0 9.0 17.4 4.2 0.8
Number of children fathered 3.3 3.7 4.8 2.2 -1.6
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.7 2.1 -1.4 1.2
Age at first live birth 0.7 1.3 1.6 1.0 1.3
Pulse wave peak to peak time 1.6 1.9 2.3 1.2 1.5
Health satisfaction 0.7 0.8 1.0 0.8 -1.0
Shortness of breath walking on level ground 1.5 1.8 1.9 1.3 -1.4
Qualifications: College or University degree 0.1 0.3 0.5 -0.7 0.3
Eye problems/disorders: None of the above 0.6 0.7 1.2 -1.1 -0.5
Mouth/teeth dental problems: Loose teeth 0.6 0.7 0.8 -0.9 0.8
Emphysema/chronic bronchitis 2.1 2.4 3.7 1.0 1.9
Medication for pain relief, constipation, heartburn 2.9 4.9 6.1 -2.5 -2.0
Neck or shoulder pain in last month 0.3 0.5 0.9 0.9 0.2
Medication: Blood pressure 0.0 0.1 0.1 -0.1 -0.4
Angina (self-reported) 0.3 0.4 0.5 0.7 -0.4
Migraine (self-reported) 1.2 1.5 2.3 0.9 -1.5
Medication: Ibuprofen 4.4 5.3 8.8 3.0 1.3
Medication: Allopurinol 2.9 3.9 7.3 -2.7 0.7
Medication: Omeprazole 1.5 1.7 2.6 -0.9 1.6
Medication: Seretide 50 evohaler 3.1 3.6 6.6 2.6 0.7
Mean time to correctly identify matches 1.3 2.4 2.7 -1.7 1.5
Heart disease (mother) 1.9 2.3 4.6 -0.0 2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.3 -0.2 -0.5
Whole body fat mass 0.8 3.2 4.0 -1.5 -2.0
Leg fat mass (right) 1.1 4.1 4.8 -2.2 -1.8
Arm predicted mass (right) 0.5 2.4 3.6 1.9 -1.1
Pulse rate, automated reading 24.6 79.4 158.8 -12.6 0.3
Alcohol intake frequency. 0.2 0.4 0.6 0.4 -0.8
Comparative height size at age 10 1.2 6.5 11.2 3.3 -1.4
Number of full sisters 0.6 0.8 1.3 -0.6 -1.1
Suffer from ‘nerves’ 0.2 0.3 0.5 0.7 0.4
Overall health rating 0.9 1.9 2.7 1.6 -1.1
Chest pain or discomfort 0.4 0.6 1.0 1.0 -0.4
Had major operations 2.0 2.3 4.3 -2.1 -0.6
Age at last live birth 0.9 1.4 1.4 1.2 1.2
Family relationship satisfaction 2.6 3.2 5.5 -2.3 -0.9
Leg pain on walking 1.0 1.3 2.2 1.5 0.6
Qualifications: NVQ or HND or HNC or equivalent 5.8 7.0 10.5 3.2 1.9
Commuting to job workplace: Car/motor vehicle 5.7 6.5 8.6 2.9 -2.1
Illness, injury, bereavement, stress in last 2 years 1.5 1.9 2.6 -1.6 -1.1
Medication: Aspirin 0.2 0.3 0.5 0.4 0.7
Supplements: Vitamin C 0.7 0.8 1.5 1.2 0.4
Knee pain experienced in last month 0.2 0.3 0.6 0.2 0.8
Hypertension (Self-reported) 0.5 1.3 2.7 -1.6 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.1 0.3 0.3
Illnesses of father: Heart disease 0.7 1.0 1.3 0.8 1.1
Illnesses of siblings: Diabetes 0.1 0.1 0.2 0.4 0.2
Smoking status: Previous 1.2 1.8 2.0 1.4 -1.3
Forced expiratory volume in 1-second (FEV1), predicted 4.5 9.4 17.3 4.2 1.3
Whole body fat-free mass 0.6 3.5 4.2 2.0 -1.7
Leg fat-free mass (right) 0.6 3.3 3.6 1.9 -1.7
Arm fat percentage (left) 1.3 5.2 6.6 -2.6 -1.9
Average weekly red wine intake 0.2 0.3 0.6 -0.3 -0.7
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.1 0.4 -0.4
Mood swings 0.6 1.1 1.3 -1.2 -1.0
Loneliness, isolation 0.3 0.4 0.7 0.0 -0.8
Long-standing illness, disability or infirmity 2.9 4.4 8.3 2.9 0.7
Ever had bowel cancer screening 0.1 0.1 0.1 0.4 -0.4
Diabetes diagnosed by doctor 0.1 0.2 0.4 0.6 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 1.3 1.1 0.8
Friendships satisfaction 1.3 1.6 2.7 0.8 -1.6
Qualifications: nursing, teaching 0.2 0.3 0.6 -0.8 0.2
Commuting to job workplace: Walk 1.2 1.3 1.6 -1.3 1.0
Eye problems/disorders: Cataract 1.2 1.3 2.6 1.6 0.3
Mouth/teeth dental problems: Mouth ulcers 1.9 3.1 6.1 -2.5 0.2
Medication for cholesterol 0.9 1.4 2.6 -1.6 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.1 2.4 4.7 2.2 -0.4
Back pain experienced in last month 0.7 1.0 1.3 1.2 -0.8
Mineral and other dietary supplements 4.0 5.4 10.8 -3.3 0.1
Breast cancer (self-reported) 0.1 0.1 0.2 -0.4 0.2
Asthma (self-reported) 10.5 20.9 41.7 6.5 -0.0
Osteoporosis (self-reported) 3.0 3.8 6.3 2.5 -1.1
Osteoarthritis (self-reported) 0.1 0.1 0.1 -0.0 0.4
Medication: Aspirin 0.6 0.8 1.1 0.7 1.1
Medication: Gliclazide 0.5 0.5 1.1 -0.2 -1.0
Illnesses of father: None of the above (group 1) 1.2 1.5 1.7 -1.1 -1.3
Smoking status: Current 0.3 0.6 1.1 -0.2 1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.3 -0.6 0.3
Whole body water mass 0.6 3.5 4.1 2.0 -1.7
Leg predicted mass (right) 0.6 3.3 3.6 1.9 -1.7
Arm fat mass (left) 1.0 4.1 4.7 -1.9 -2.2
Number of self-reported non-cancer illnesses 3.2 5.6 11.2 3.3 -0.0
Average weekly champagne plus white wine intake 9.2 12.6 24.7 -5.0 -0.7
Miserableness 4.4 7.6 12.8 -3.6 -1.6
Guilty feelings 0.8 1.1 2.2 -0.2 -1.5
Wears glasses or contact lenses 1.3 1.5 2.3 -1.5 0.8
Ever taken oral contraceptive pill 0.9 0.9 1.6 1.3 -0.5
Hearing aid user 2.0 2.3 4.2 2.0 0.6
Mother’s age at death 0.9 1.2 1.9 -1.4 -0.7
Financial situation satisfaction 0.7 0.9 1.3 1.1 -0.7
Tinnitus: Yes, now most or all of the time 0.6 0.7 0.7 -0.9 0.9
Commuting to job workplace: Public transport 4.0 4.8 6.5 -2.5 1.8
Eye problems/disorders: Glaucoma 0.1 0.1 0.2 0.4 0.3
Medication: Blood pressure 0.4 0.7 1.1 -1.0 -0.5
Pain type(s) experienced in last month: Hip pain 1.1 1.4 2.1 1.5 0.8
Supplements: Fish oil (including cod liver oil) 5.4 7.1 14.1 3.8 -0.1
High cholesterol (Self-reported) 4.2 7.4 14.6 3.8 -0.4
Medication: Bendroflumethiazide 0.2 0.3 0.5 0.1 -0.7
Medication: Paracetamol 1.7 2.6 4.3 2.1 0.9
Medication: Lisinopril 1.9 2.4 3.9 -2.0 1.0
Medication: Atorvastatin 0.1 0.1 0.2 -0.1 -0.4
Illnesses of father: High blood pressure 0.6 0.7 1.4 1.2 -0.3
Alcohol drinker status: Never 0.8 0.9 1.7 -0.3 1.3
Ever smoked 1.1 1.9 2.1 1.3 -1.5
Basal metabolic rate 0.5 3.0 3.6 1.6 -1.9
Leg fat percentage (left) 1.8 6.5 11.4 -3.4 -1.2
Arm fat-free mass (left) 0.4 1.9 2.9 1.0 -1.7
Number of operations (self-reported) 0.1 0.2 0.4 0.0 -0.6
Average weekly beer plus cider intake 0.5 0.7 1.3 -1.1 -0.4
Irritability 7.6 12.8 20.1 -4.5 -2.3
Risk taking 0.1 0.1 0.1 0.3 0.3
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.1 0.2 0.3
Fractured/broken bones in last 5 years 4.2 5.4 10.6 3.2 0.5
Age started oral contraceptive pill 1.0 1.2 1.3 -1.1 -1.1
Diastolic blood pressure, automated reading 2.2 6.7 12.6 -3.5 0.9
Ever depressed for a whole week 1.9 2.4 4.7 -2.2 -0.2
Unable to work because of sickness or disability 0.1 0.1 0.2 -0.5 0.1
Commuting to job workplace: Cycle 2.5 3.0 3.4 -1.8 1.6
Myopia 3.8 5.6 11.0 -3.3 -0.3
Vascular/heart problems diagnosed by doctor 0.8 2.1 3.9 2.0 0.5
Cholesterol lowering medication 3.4 5.0 9.6 3.1 -0.6
Medication: Omeprazole (e.g. Zanprol) 2.0 2.4 3.9 -0.9 2.0
Pain experienced in last month 0.4 0.7 1.4 -0.2 -1.2
Supplements: Calcium 1.6 1.8 3.5 1.9 -0.3
Basal cell carcinoma (self-reported) 3.6 4.2 6.0 2.4 1.6
Heart attack/myocardial infarction (self-reported) 3.8 4.9 8.5 2.9 1.2
Deep venous thrombosis (DVT) (self-reported) 6.7 8.6 14.4 3.8 1.7
Heart disease (siblings) 0.3 0.3 0.3 0.6 -0.6
Alcohol drinker status: Previous 0.7 0.8 1.5 -0.4 -1.2
Pack years of smoking 0.2 0.3 0.5 -0.4 -0.7
Impedance of whole body 0.5 2.4 4.4 2.1 0.6
Leg fat mass (left) 1.0 3.7 4.4 -2.1 -1.8
Arm predicted mass (left) 0.3 1.8 2.3 1.1 -1.5