Best TWAS P=2.26e-15 · Best GWAS P=7.67e-13 conditioned to 0.0963
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FURIN | 0.12 | 0.14 | lasso | 2 | 0.13 | 1.2e-15 | 5.7 | -5.7 | 1.6e-08 | 0.84 | 0.95 | 0.05 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | FES | 0.21 | 0.09 | lasso | 5 | 0.05 | 1.3e-03 | -6.1 | 5.8 | 5.5e-09 | -0.69 | 0.39 | 0.24 | FALSE |
| 3 | GTEx | Artery Tibial | FES | 0.16 | 0.04 | lasso | 5 | 0.05 | 4.8e-05 | -4.8 | 5.8 | 6.5e-09 | -0.72 | 0.20 | 0.78 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | FES | 0.28 | 0.17 | enet | 21 | 0.20 | 2.8e-15 | -6.1 | 7.3 | 3.5e-13 | -0.89 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Lung | FES | 0.24 | 0.07 | lasso | 6 | 0.05 | 5.1e-05 | -4.8 | 6.2 | 6.3e-10 | -0.79 | 0.11 | 0.87 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | FES | 0.09 | 0.04 | lasso | 5 | 0.04 | 1.4e-04 | -6.1 | 5.8 | 7.9e-09 | -0.65 | 0.10 | 0.58 | FALSE |
| 7 | GTEx | Thyroid | FES | 0.33 | 0.19 | lasso | 6 | 0.18 | 4.3e-14 | -5.7 | 5.6 | 2.0e-08 | -0.70 | 0.95 | 0.05 | TRUE |
| 8 | METSIM | Adipose | FES | 0.08 | 0.06 | lasso | 3 | 0.05 | 6.8e-08 | -5.5 | 5.7 | 1.6e-08 | -0.64 | 0.94 | 0.06 | FALSE |
| 9 | YFS | Blood | FES | 0.31 | 0.11 | enet | 77 | 0.22 | 1.2e-68 | -6.1 | 6.8 | 9.1e-12 | -0.68 | 0.02 | 0.98 | FALSE |
| 10 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | FES | 0.06 | 0.05 | blup | 46 | 0.06 | 1.9e-05 | -7.1 | 7.5 | 6.6e-14 | -0.83 | 0.00 | 0.99 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FES | 0.06 | 0.05 | blup | 46 | 0.07 | 7.4e-14 | -6.1 | 7.9 | 2.3e-15 | -0.89 | 0.01 | 0.99 | TRUE |
| 12 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FES | 0.06 | 0.02 | blup | 46 | 0.02 | 2.4e-02 | -6.1 | 6.0 | 1.8e-09 | -0.77 | 0.01 | 0.81 | FALSE |
| 13 | The Cancer Genome Atlas | Colon Adenocarcinoma | FES | 0.08 | 0.07 | blup | 46 | 0.06 | 3.4e-04 | -6.8 | 6.3 | 2.4e-10 | -0.92 | 0.01 | 0.98 | FALSE |
| 14 | The Cancer Genome Atlas | Glioblastoma Multiforme | FES | 0.12 | 0.06 | enet | 6 | 0.06 | 5.7e-03 | -7.2 | 6.6 | 4.3e-11 | -0.96 | 0.00 | 0.94 | FALSE |
| 15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FES | 0.06 | 0.03 | blup | 46 | 0.05 | 5.6e-06 | -7.2 | 7.9 | 3.6e-15 | -0.81 | 0.01 | 0.99 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FES | 0.10 | 0.07 | enet | 5 | 0.05 | 2.8e-06 | -7.2 | 7.1 | 1.0e-12 | -0.98 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | FES | 0.05 | 0.04 | lasso | 2 | 0.04 | 2.2e-05 | -6.1 | 7.0 | 1.9e-12 | -0.88 | 0.01 | 0.99 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FES | 0.08 | 0.07 | enet | 7 | 0.08 | 4.2e-09 | -6.1 | 6.4 | 1.5e-10 | -0.81 | 0.06 | 0.94 | FALSE |
| 19 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | FES | 0.13 | 0.16 | lasso | 2 | 0.14 | 6.1e-10 | -6.1 | 6.0 | 1.6e-09 | -0.71 | 0.65 | 0.35 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FES | 0.12 | 0.09 | lasso | 5 | 0.08 | 4.1e-09 | -6.1 | 6.7 | 1.9e-11 | -0.79 | 0.14 | 0.86 | FALSE |
| 21 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FES | 0.04 | 0.01 | blup | 46 | 0.02 | 1.7e-02 | -7.1 | 7.3 | 3.6e-13 | -0.78 | 0.01 | 0.69 | FALSE |
| 22 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | FES | 0.32 | 0.26 | lasso | 2 | 0.25 | 2.0e-09 | -6.0 | 6.0 | 1.5e-09 | -0.72 | 0.35 | 0.64 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | FES | 0.30 | 0.30 | lasso | 7 | 0.32 | 1.3e-31 | -6.0 | 6.9 | 3.8e-12 | -0.86 | 0.80 | 0.20 | FALSE |