TWAS
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Models
Genes
Traits
[Hub]/) :
Traits
:
Age at first live birth
:
←
chr19:18,333,894-20,313,262
Best TWAS P=1.45e-08 · Best GWAS P=3.24e-08 conditioned to 0.0373
18.5M
19M
19.5M
20M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
ROSMAP
Brain Pre-frontal Cortex
SUGP1
0.03
0.00
blup
364
0.01
4.3e-02
-5.5
-5.7
1.5e-08
0.72
0.01
0.90
TRUE
1
CommonMind
Brain Pre-frontal Cortex
MAU2
0.09
0.08
blup
369
0.10
1.0e-12
-3.3
5.6
2.0e-08
-0.73
0.43
0.56
FALSE
3
GTEx
Esophagus Mucosa
GATAD2A
0.11
0.02
lasso
3
0.02
2.3e-02
-5.5
-5.6
2.7e-08
0.91
0.01
0.91
FALSE
2
GTEx
Brain Hippocampus
DDX49
0.23
-0.01
lasso
4
-0.01
6.6e-01
-5.5
5.2
2.3e-07
-0.96
0.01
0.71
FALSE