TWAS hub - SUGP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.1144	0.0361	6.8e-08	0.056	NA	0.065	NA	0.074	3.5e-06	NA	5.7e-07	NA	9.5e-08
2	ROSMAP	Brain Pre-frontal Cortex	0.0342	0.0169	6.9e-03	0.002	0.006	0.000	0.006	0.003	1.4e-01	0.043	3.6e-01	0.045	1.1e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Maternal smoking around birth	12.2	17.7	34.8	-0.8	5.9
Age at first live birth	9.2	16.3	32.1	0.6	-5.7
Bipolar Disorder (2018)	8.5	13.4	22.7	-4.8	-2.0
Triglycerides	8.4	13.8	23.4	2.0	-4.8
Blood Platelet Count	8.2	95.0	130.0	-11.4	7.8
High cholesterol (Self-reported)	7.8	13.9	14.4	3.8	-3.6
Rheumatoid Arthritis	7.7	10.6	19.6	-4.4	1.2
Schizophrenia (2014)	7.3	16.1	21.6	-4.7	3.2
Impedance of arm (right)	7.3	34.2	46.6	-6.8	-4.7
Medication: Cholesterol lowering	7.3	11.3	13.6	3.7	-3.0
Breast Cancer	7.1	17.0	26.8	5.2	-2.7
Medication: Paracetamol	7.1	11.7	23.3	0.3	4.8
Bipolar Disorder or Schizophrenia	7.0	17.2	33.7	-5.8	0.8
Impedance of arm (left)	6.9	32.2	45.7	-6.8	-4.3
Mouth/teeth dental problems: Bleeding gums	6.7	8.7	16.4	4.0	1.0
Sensitivity / hurt feelings	6.6	11.3	12.1	-3.2	3.5
Townsend deprivation index at recruitment	6.5	9.1	18.2	4.3	-0.0
Myopia	6.5	9.4	18.1	-4.2	0.8
Hearing difficulty/problems: Yes	6.2	9.4	18.8	4.3	-0.0
Mother’s age at death	6.2	7.7	8.4	2.9	-2.7
Impedance of whole body	6.0	30.6	60.5	-7.8	-0.9
Medication for pain relief, constipation, heartburn	5.9	10.1	16.2	-2.0	-4.0
Comparative body size at age 10	5.6	15.4	28.1	5.3	-1.6
Medication: Paracetamol	5.3	8.3	16.3	0.5	4.0
Overall health rating	5.2	11.1	22.1	0.2	4.7
Age at last live birth	5.2	7.6	14.9	0.5	-3.9
Chest pain or discomfort	5.1	7.4	11.4	1.9	3.4
Leg fat percentage (left)	5.1	18.3	28.9	2.8	5.4
Impedance of leg (right)	5.0	24.3	41.9	-6.5	2.6
Impedance of leg (left)	5.0	24.1	40.7	-6.4	2.7
Exposure to tobacco smoke at home	5.0	5.6	10.5	-0.9	3.2
Guilty feelings	5.0	7.6	14.3	3.8	0.9
Schizophrenia (2018)	4.9	10.2	13.1	-3.6	2.7
Pulse wave reflection index	4.8	6.0	9.7	3.1	1.5
Leg fat percentage (right)	4.8	17.4	28.4	2.5	5.3
Medication: Simvastatin	4.6	6.7	7.1	2.5	-2.7
Illnesses of siblings: Diabetes	4.6	5.7	10.7	-0.8	3.3
Medication: Gliclazide	4.6	5.2	9.9	-0.6	3.2
BMI	4.4	25.7	38.3	6.2	3.6
Height	4.4	84.1	96.0	-9.8	-8.5
Medication: Co-codamol	4.4	5.1	9.2	-1.0	3.0
Smoking status: Current	4.4	7.0	12.8	-1.1	3.6
LDL Cholesterol	4.3	6.8	13.3	0.6	-3.6
Body mass index (BMI)	4.3	18.3	24.0	4.9	3.6
Age started oral contraceptive pill	4.3	5.4	6.2	-2.1	-2.5
Prostate Cancer	4.2	6.0	9.0	-3.0	1.7
Pain all over the body in last month	4.2	4.5	8.2	0.9	2.9
Age at First Birth	4.1	5.9	10.6	-1.1	-3.3
Type 2 Diabetes (T2D) (2018)	4.0	7.5	14.9	-0.1	3.9
Current tobacco smoking	4.0	6.6	12.3	-1.0	3.5
Illnesses of siblings	4.0	5.6	11.0	0.5	-3.3
Number of treatments/medications taken	3.9	7.1	12.6	1.3	3.5
Medication: Levothyroxine sodium	3.9	6.5	8.5	-2.9	2.1
Forced expiratory volume in 1-second (FEV1), predicted	3.9	8.1	13.1	-3.6	-1.8
Diabetes (mother)	3.8	4.8	6.7	-1.7	2.6
Qualifications: None of the above	3.8	8.2	16.2	-0.5	4.0
Risk taking	3.8	5.5	7.1	-2.7	2.0
Waist circumference	3.7	13.5	17.6	4.2	3.1
Frequency of tiredness / lethargy in last 2 weeks	3.7	6.0	11.9	0.3	3.5
Number of live births	3.7	5.2	10.5	-0.1	3.2
Chronic bronchitis/emphysema (mother)	3.7	4.4	6.5	1.5	2.5
Unable to work because of sickness or disability	3.7	4.8	9.4	0.2	3.1
Blood Eosinophil Count	3.6	27.8	41.2	-6.4	3.8
Taking other prescription medications	3.6	5.5	10.3	-0.8	3.2
Qualifications: A levels/AS levels or equivalent	3.6	8.0	16.1	-0.1	-4.0
Standing height	3.6	35.9	40.8	-5.6	-6.4
Birth weight of first child	3.6	6.6	13.0	-0.4	-3.6
Illnesses of father: Heart disease	3.5	4.8	6.2	1.8	-2.5
Type 2 Diabetes (T2D) (2012)	3.4	3.9	6.3	-1.2	2.5
Qualifications: O levels/GCSEs or equivalent	3.4	5.4	6.2	-2.5	-2.1
Diastolic blood pressure, automated reading	3.4	10.5	21.0	0.1	4.6
Worry (Nagel 2018)	3.3	6.9	11.2	-3.3	1.6
Loneliness, isolation	3.3	4.6	7.2	1.4	2.7
Breast cancer (self-reported)	3.3	3.9	7.0	-2.6	1.0
Ever taken oral contraceptive pill	3.2	3.6	6.4	2.5	0.9
Sitting height	3.1	22.2	34.1	-5.8	-3.2
Financial difficulties in last 2 years	3.1	4.2	4.4	2.1	2.0
Medication: Lansoprazole	3.1	3.5	6.5	0.7	2.6
Depressed Affect (Nagel 2018)	2.9	6.2	12.1	0.5	3.5
Hypothyroidism/myxoedema (self-reported)	2.9	5.7	7.2	-2.7	2.0
Neuroticism (Nagel 2018)	2.8	6.6	10.2	-1.8	3.2
Breastfed as a baby	2.8	3.5	3.9	-1.7	-2.0
Long-standing illness, disability or infirmity	2.8	4.4	5.0	1.9	2.2
Ovarian Cancer	2.7	3.6	7.2	2.7	-0.2
Medication: Metformin	2.7	3.8	7.6	-0.2	2.8
Stomach or abdominal pain in last month	2.7	3.3	6.2	-0.7	2.5
Depression (self-reported)	2.7	3.3	3.4	1.8	1.8
Qualifications: College or University degree	2.7	8.5	15.7	1.2	-4.0
Medication: Atorvastatin	2.7	3.3	3.6	1.9	-1.7
High blood pressure (mother)	2.6	3.7	7.1	-2.7	0.6
Mouth/teeth dental problems	2.6	4.0	4.4	-1.9	-2.1
Alcohol intake versus 10 years previously	2.6	3.9	6.6	-1.1	2.6
Wheeze or whistling in the chest in last year	2.6	4.7	8.1	1.1	2.8
Qualifications: nursing, teaching	2.6	4.1	6.7	1.2	-2.6
Pain experienced in last month	2.6	4.4	8.7	-0.2	-3.0
Father’s age at death	2.5	3.4	3.8	-1.7	-2.0
Birth weight	2.5	5.5	11.0	-0.2	-3.3
Health satisfaction	2.5	3.2	3.9	2.0	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.5	2.9	5.5	2.4	-0.6
Handedness (chirality/laterality): Left-handed	2.5	3.0	4.7	-1.1	-2.2
Medication: Aspirin	2.5	3.2	5.8	2.4	0.8
Leg fat mass (left)	2.5	9.8	11.0	2.9	3.3
Frequency of depressed mood in last 2 weeks	2.4	3.4	6.5	2.5	-0.5
Hayfever, allergic rhinitis or eczema	2.4	5.1	9.8	-0.7	-3.1
Medication: Ramipril	2.4	3.1	4.3	-1.4	2.1
Medication: Ibuprofen	2.4	2.8	5.0	0.8	2.2
Leg fat mass (right)	2.4	9.4	11.2	2.8	3.3
Comparative height size at age 10	2.4	13.4	25.3	-1.2	-5.0
Diabetes diagnosed by doctor	2.4	3.9	7.7	0.0	2.8
Mouth/teeth dental problems: Mouth ulcers	2.4	3.8	6.5	-2.5	1.1
Angina	2.3	3.1	5.6	2.4	0.7
Vitamin and mineral supplements	2.3	3.1	4.2	1.4	-2.0
Qualifications: CSEs or equivalent	2.3	3.1	6.1	0.3	2.5
Had major operations	2.3	2.7	3.7	1.9	-1.3
Ulcerative Colitis (UC)	2.2	4.1	8.2	-2.9	0.1
Happiness	2.2	2.6	4.1	1.1	-2.0
Angina (self-reported)	2.2	2.9	5.2	2.3	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.5	2.8	-1.5	1.7
Back pain experienced in last month	2.2	3.1	5.6	2.4	0.8
Waist Hip Ratio (WHR)	2.1	9.6	10.8	2.9	3.3
Headache pain in last month	2.1	3.6	7.1	-0.5	2.7
Forced vital capacity (FVC), Best measure	2.1	7.7	10.8	-2.1	-3.3
Osteoarthritis (self-reported)	2.1	2.8	5.2	0.6	2.3
Number of self-reported non-cancer illnesses	2.1	3.6	5.9	1.1	2.4
Hair/balding pattern: Pattern 2	2.0	2.6	5.1	-0.1	2.3
Medication: Allopurinol	2.0	2.6	5.0	-0.5	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	2.6	1.6	1.4
Commuting to job workplace: Walk	2.0	2.1	3.7	1.9	-0.8
Eye problems/disorders: Glaucoma	2.0	2.3	3.0	1.7	-1.3
Schizophrenia vs Biploar Disorder	1.9	2.5	5.0	0.0	2.2
Smoking Status	1.9	4.6	9.0	-0.5	3.0
Average weekly spirits intake	1.9	2.3	3.9	0.9	2.0
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	3.2	1.0	1.8
Pulse rate	1.9	3.3	4.6	-2.1	1.4
Glaucoma (self-reported)	1.9	2.2	3.7	1.9	-0.8
Medication: Omeprazole	1.9	2.2	3.8	1.9	0.8
Pain type(s) experienced in last month: Hip pain	1.9	2.4	4.2	-0.8	2.0
Irritable Bowel Disease (IBD)	1.8	4.3	7.7	-2.8	0.9
Nervous feelings	1.8	3.4	6.4	-2.5	0.7
Hair/balding pattern: Pattern 3	1.8	2.6	4.6	0.8	-2.1
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	3.4	0.8	-1.8
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	4.6	-2.2	1.2
Financial situation satisfaction	1.8	2.3	3.9	2.0	-0.8
Alzheimer’s Disease (in father)	1.7	1.9	3.3	0.7	1.8
Allergy or Eczema	1.7	4.5	7.7	-1.2	-2.8
Hypothyroidism (self reported)	1.7	3.9	5.8	-2.4	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.2	3.4	1.0	1.8
Age when periods started (menarche)	1.7	4.1	8.2	-2.9	-0.3
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	3.1	1.8	1.0
Body Mass Index (BMI) (2010)	1.6	2.2	4.3	2.1	-0.3
Coronary Artery Disease (CAD)	1.6	1.9	3.6	0.4	-1.9
Fed-up feelings	1.6	3.0	5.6	0.6	2.4
Neck or shoulder pain in last month	1.6	2.2	2.7	-1.6	1.3
Mean time to correctly identify matches	1.6	3.0	5.9	2.4	0.2
Medication: Blood pressure	1.6	3.0	5.2	-0.9	2.3
Depression (Nagel 2018)	1.5	2.3	3.0	1.7	1.3
Supplements: Glucosamine	1.5	2.0	3.4	-0.8	-1.8
Alcohol usually taken with meals	1.5	2.4	3.1	-1.8	-1.3
Forced vital capacity (FVC)	1.5	5.9	9.1	-1.6	-3.0
Migraine (self-reported)	1.5	1.9	2.8	1.7	1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	2.0	-1.1	1.4
Miserableness	1.5	2.5	2.9	1.5	1.7
Hearing aid user	1.5	1.7	2.2	1.5	1.1
Hand grip strength (left)	1.4	3.7	6.7	-0.8	-2.6
Pack years adult smoking proportion	1.4	2.1	3.9	-0.5	2.0
Diabetes (self-reported)	1.4	2.1	4.2	-0.1	2.0
Prospective memory result	1.4	1.7	1.9	-1.2	1.4
Medication: Aspirin	1.4	1.9	3.6	1.9	0.4
Average weekly red wine intake	1.4	2.1	4.2	-2.0	-0.2
Lupus	1.3	1.9	2.6	-1.6	-1.1
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	2.7	0.4	1.6
Fluid intelligence score	1.3	2.7	3.6	1.3	-1.9
Mouth/teeth dental problems: Dentures	1.3	2.3	4.3	0.4	2.1
Arm fat mass (right)	1.3	5.4	7.8	2.8	1.7
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.6	-1.6	-0.8
Leg fat-free mass (right)	1.3	6.7	7.7	2.4	-2.8
Leg predicted mass (right)	1.3	6.8	7.9	2.4	-2.8
Mean Putamen Volume	1.2	1.4	2.7	-1.6	-0.4
Allergy	1.2	2.8	5.4	0.4	2.3
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	2.6	0.7	1.6
High blood pressure (siblings)	1.2	1.8	2.3	-1.1	1.5
Shortness of breath walking on level ground	1.2	1.5	2.7	0.5	1.6
Suffer from ‘nerves’	1.2	1.9	2.8	-1.7	1.0
Arm fat mass (left)	1.2	4.9	7.3	2.7	1.5
Commuting to job workplace: Public transport	1.2	1.4	1.8	1.3	-1.0
Crohns Disease (2017)	1.1	2.4	4.1	-2.0	0.9
Reaction Time	1.1	2.1	4.1	2.0	0.1
Blood White Count	1.1	8.1	8.4	-2.8	2.9
Systolic Blood Pressure	1.1	5.6	10.9	-3.3	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.6	6.2	-1.0	-2.5
Body fat percentage	1.1	4.5	7.5	1.2	2.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	1.7	1.1	1.3
Pulse wave peak to peak time	1.1	1.3	2.5	-0.4	-1.6
Supplements: Vitamin C	1.1	1.3	1.9	-0.8	1.4
Arm fat percentage (left)	1.1	4.2	5.7	2.4	1.7
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.6	-0.3	1.6
Irritability	1.1	1.9	2.3	-1.5	-1.2
Alcohol drinker status: Previous	1.1	1.3	2.5	-0.1	1.6
HbA1C	1.0	1.1	1.7	1.3	0.7
Blood Red Count	1.0	9.3	15.6	4.0	1.7
Cardiovascular Disease	1.0	3.2	5.9	2.4	0.7
Respiratory disease	1.0	2.2	3.6	0.9	1.9
Leg fat-free mass (left)	1.0	5.2	5.5	2.2	-2.4
Leg predicted mass (left)	1.0	5.3	5.8	2.2	-2.4
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	2.4	1.6	0.3
Arm fat percentage (right)	1.0	3.9	5.4	2.3	1.6
Worrier / anxious feelings	1.0	2.0	3.7	-0.5	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.6	0.7	1.6
Peak expiratory flow (PEF)	1.0	2.4	4.2	0.8	-2.0
Gout (self-reported)	1.0	1.4	2.8	-0.2	1.7
Exposure to tobacco smoke outside home	1.0	1.3	2.6	0.1	1.6
Average weekly beer plus cider intake	1.0	1.4	1.8	-1.0	1.4
Lung FEV1/FVC ratio	0.9	4.5	6.1	2.5	1.7
Chronotype (morning person)	0.9	2.1	4.0	-0.5	-2.0
Severe depression (siblings)	0.9	1.0	1.8	-1.3	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	3.0	1.7	-0.0
Illnesses of mother	0.9	1.1	1.6	0.8	-1.3
Heart disease (mother)	0.9	1.1	1.2	1.0	-1.1
Medication for cholesterol	0.9	1.4	2.2	0.8	-1.5
Illnesses of father: High blood pressure	0.9	1.1	2.0	-0.4	1.4
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.0	1.4	0.2
Vascular/heart problems diagnosed by doctor	0.9	2.3	3.3	-1.2	-1.8
Supplements: Calcium	0.9	1.0	1.6	-1.3	0.6
Fasting Glucose	0.8	1.0	1.2	-0.9	1.1
Ulcerative Colitis	0.8	1.1	1.8	-0.7	1.3
Heel T-Score	0.8	6.7	12.9	-0.7	3.6
Neuroticism	0.8	2.0	2.5	-1.2	1.6
Relative age voice broke	0.8	1.2	2.1	-1.4	0.6
Multivitamins +/- minerals	0.8	1.0	1.4	-0.7	1.2
Hearing difficulty/problems with background noise	0.8	1.3	2.5	1.6	0.4
Had menopause	0.8	1.0	2.0	1.4	-0.0
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	4.6	-0.8	-2.1
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.6	-1.3	0.5
Ever had bowel cancer screening	0.8	0.9	1.7	-0.4	1.3
Whole body water mass	0.8	4.6	5.5	2.3	-1.9
Average weekly champagne plus white wine intake	0.8	1.1	2.0	1.4	-0.5
Crohns Disease (2012)	0.7	1.1	1.5	-0.9	1.2
Pulse wave Arterial Stiffness index	0.7	0.8	1.6	-0.2	1.3
Emphysema/chronic bronchitis	0.7	0.8	0.9	0.8	1.0
Whole body fat mass	0.7	2.9	3.3	1.8	1.6
Pulse rate, automated reading	0.7	2.4	3.1	-1.8	1.3
Number of full sisters	0.7	0.9	1.0	-1.0	0.9
Family relationship satisfaction	0.7	0.8	1.2	1.1	0.7
Hypertension (Self-reported)	0.7	1.8	3.2	0.6	1.8
Whole body fat-free mass	0.7	4.3	5.0	2.2	-1.9
Osteoporosis (self-reported)	0.7	0.9	1.2	1.1	0.8
Cholesterol lowering medication	0.7	1.1	1.8	-0.6	-1.4
Pack years of smoking	0.7	1.1	1.9	-0.5	1.4
Alzheimer’s Disease (including proxy)	0.6	0.9	1.8	-0.1	1.3
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.5	0.4	1.2
Systolic blood pressure, automated reading	0.6	1.7	3.4	-1.8	0.1
Average weekly fortified wine intake	0.6	0.7	1.5	1.2	-0.1
Serious illness, injury or assault to yourself	0.6	0.7	1.3	0.5	1.1
Trunk fat-free mass	0.6	3.6	3.8	1.9	-1.8
Falls in the last year	0.6	0.8	1.2	-1.1	0.7
Trunk predicted mass	0.6	3.4	3.6	1.9	-1.8
Tense / ‘highly strung’	0.6	1.0	1.9	-1.4	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	0.9	-1.0	0.7
Arm predicted mass (right)	0.6	2.9	5.5	2.4	0.4
Alcohol intake frequency.	0.6	1.4	1.7	-1.3	1.0
Basal metabolic rate	0.6	3.3	4.9	2.2	-1.3
Fractured/broken bones in last 5 years	0.6	0.7	1.4	1.2	-0.0
Commuting to job workplace: Cycle	0.6	0.8	1.2	0.6	-1.1
Supplements: Zinc	0.5	0.6	1.1	-0.3	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.3	-0.4	1.5
Had other major operations	0.5	0.6	0.8	-0.7	0.9
Weight	0.5	2.4	4.7	2.2	0.4
Time employed in main current job	0.5	0.6	1.0	-0.5	1.0
Noisy workplace	0.5	0.7	0.8	-0.7	-0.9
Hair/balding pattern: Pattern 4	0.5	1.2	2.1	1.4	0.5
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.4	-0.0	1.2
Arm fat-free mass (right)	0.5	2.5	4.8	2.2	0.5
Medication: Seretide 50 evohaler	0.5	0.5	1.0	0.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.2	1.5	-0.1
Arm fat-free mass (left)	0.5	2.3	4.4	2.1	0.4
Intelligence (Savage-Jansen 2018)	0.4	1.1	1.9	0.5	-1.4
HDL Cholesterol	0.4	0.7	1.3	-0.1	-1.2
High blood pressure	0.4	1.3	2.2	0.6	1.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.9	1.0	0.1
Hip circumference	0.4	1.8	2.9	1.7	0.8
Loud music exposure frequency	0.4	0.5	0.8	-0.4	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.9	0.2	1.0
Medication: Bendroflumethiazide	0.4	0.6	0.7	-0.7	0.8
Basal cell carcinoma (self-reported)	0.4	0.5	1.0	-1.0	0.3
Heart disease (siblings)	0.4	0.5	0.8	0.9	0.5
Arm predicted mass (left)	0.4	2.2	4.3	2.1	0.4
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.1	1.1	-0.6
Neuroticism (2016)	0.3	0.4	0.8	0.1	0.9
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.8	0.9	-0.2
Trunk fat percentage	0.3	1.1	2.2	0.2	1.5
Hand grip strength (right)	0.3	0.8	1.6	-0.1	-1.3
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.4	-0.6	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.5	-0.1	1.2
Neuroticism score	0.3	0.7	1.4	-0.3	1.2
Number of full brothers	0.3	0.4	0.7	-0.8	0.4
Number of children fathered	0.3	0.3	0.6	0.3	0.8
Illnesses of father: None of the above (group 1)	0.3	0.4	0.4	-0.5	0.7
Wears glasses or contact lenses	0.3	0.4	0.8	-0.9	0.1
Medication: Lisinopril	0.3	0.4	0.7	0.8	0.4
Number of operations (self-reported)	0.3	0.4	0.9	0.9	0.0
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	-0.7	0.1
Major Depression (MDD)	0.2	0.2	0.4	0.6	0.3
Medication for hormone replacement therapy	0.2	0.3	0.5	0.1	0.7
Diabetes (father)	0.2	0.3	0.4	-0.4	0.6
Medication: Atenolol	0.2	0.3	0.5	0.0	0.7
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	0.6	0.1
Trunk fat mass	0.2	0.7	0.7	0.8	0.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.5	-0.1	-0.7
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	0.2	0.6
Blood clot in the leg (DVT)	0.2	0.3	0.5	-0.3	0.7
Medication: Amlodipine	0.2	0.3	0.5	0.7	0.3
Worry too long after embarrassment	0.2	0.3	0.5	-0.1	0.7
Eye problems/disorders: None of the above	0.2	0.2	0.3	-0.3	-0.6
Medication: Blood pressure	0.2	0.4	0.7	0.3	0.8
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.3	-0.4	0.5
Knee pain experienced in last month	0.2	0.2	0.5	0.1	0.7
Mood swings	0.2	0.4	0.9	0.0	0.9
Friendships satisfaction	0.2	0.3	0.6	0.8	-0.0
Primary Biliary Cirrhosis	0.1	0.1	0.3	0.0	0.5
Hair Pigment	0.1	1.6	3.0	1.7	0.4
Tanning	0.1	1.6	1.8	1.2	1.3
Relative age of first facial hair	0.1	0.3	0.5	0.2	0.7
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	-0.4	0.1
Number of incorrect matches in round	0.1	0.2	0.3	0.5	0.3
Past tobacco smoking	0.1	0.1	0.2	-0.2	-0.4
Heart attack	0.1	0.2	0.3	-0.5	-0.1
Asthma	0.1	0.2	0.4	0.6	0.2
Lung cancer (father)	0.1	0.1	0.1	0.1	0.4
Length of working week for main job	0.1	0.2	0.2	-0.2	0.5
Eye problems/disorders: Cataract	0.1	0.1	0.2	-0.4	0.4
Mineral and other dietary supplements	0.1	0.2	0.2	-0.5	0.3
Asthma (self-reported)	0.1	0.3	0.3	0.6	0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	0.5	0.1
Ever smoked	0.1	0.1	0.3	0.5	-0.0
Ever depressed for a whole week	0.1	0.2	0.3	0.5	-0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.1	-0.4	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.4	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Lung FVC	0.0	0.1	0.2	-0.1	-0.5
Leg pain on walking	0.0	0.0	0.1	0.3	0.1
Smoking status: Previous	0.0	0.1	0.1	0.4	0.1
Alcohol drinker status: Never	0.0	0.1	0.1	-0.3	-0.2

Hub : Genes

SUGP1

Models

Trait associations