Hub : Genes

MAU2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0930	0.0250	4.2e-12	0.082	0.105	0.097	0.105	0.100	3.5e-10	1.0e-12	7.8e-12	1.1e-12	3.5e-12
2	GTEx	Artery Tibial	0.0659	0.0287	9.6e-04	0.052	NA	0.043	NA	0.047	6.2e-05	NA	2.5e-04	NA	1.3e-04
3	GTEx	Muscle Skeletal	0.0949	0.0318	1.9e-07	0.042	NA	0.053	NA	0.054	5.2e-05	NA	6.1e-06	NA	5.1e-06
4	ROSMAP	Brain Pre-frontal Cortex	0.1684	0.0604	4.1e-05	0.050	0.042	0.048	0.057	0.048	4.5e-07	3.9e-06	7.6e-07	8.0e-08	7.5e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.0	1.5	5.6	-0.2	2.4	0.6	0.4
Bipolar Disorder or Schizophrenia	4.8	11.8	24.3	-3.2	4.9	-2.8	-2.1
Depressed Affect (Nagel 2018)	4.3	9.0	15.4	-3.9	1.7	-3.0	-2.9
Depression (Nagel 2018)	0.4	0.6	0.9	-0.9	-0.9	-0.4	-0.8
Intelligence (Savage-Jansen 2018)	0.8	2.4	4.8	2.2	-0.7	1.9	0.8
Neuroticism (Nagel 2018)	5.3	12.4	20.5	-4.5	2.8	-3.8	-2.7
Schizophrenia (2018)	7.3	15.2	20.6	-4.0	4.5	-4.1	-2.8
Schizophrenia vs Biploar Disorder	3.8	5.0	6.2	-2.5	1.4	-2.4	-2.4
Worry (Nagel 2018)	1.8	3.7	7.0	-2.6	2.1	-1.8	-0.5
Alzheimer’s Disease (in mother)	0.4	0.5	0.7	-0.6	0.8	-0.7	-0.6
Alzheimer’s Disease (in father)	0.8	0.9	2.0	-1.4	0.2	-0.9	-0.9
Alzheimer’s Disease (including proxy)	1.7	2.5	3.3	-1.8	1.0	-1.6	-1.8
Crohns Disease (2017)	1.6	3.4	4.2	-1.9	1.8	-2.0	-1.7
Irritable Bowel Disease (IBD)	2.2	5.3	6.5	-2.6	2.5	-2.4	-1.7
Ulcerative Colitis (UC)	1.5	2.7	3.7	-1.9	1.9	-1.6	-1.0
Major Depression (MDD)	0.9	1.1	1.9	0.3	-1.2	1.0	-1.4
Reaction Time	0.8	1.5	5.7	-0.1	-0.5	0.3	-2.4
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.5	1.2	-0.4	1.0	0.3
Breast Cancer	11.2	27.1	41.1	6.4	-4.9	5.4	3.7
Ovarian Cancer	1.8	2.4	3.7	1.2	-1.9	1.5	1.4
Prostate Cancer	5.3	7.4	11.4	-3.0	3.4	-2.6	-1.6
Age at First Birth	2.3	3.4	6.3	2.5	-0.0	1.7	2.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	2.4	3.2	5.2	1.6	-2.3	2.3	0.2
Coronary Artery Disease (CAD)	3.4	4.0	7.0	2.6	-1.2	2.6	0.8
Crohns Disease (2012)	1.6	2.5	3.2	-1.7	1.1	-1.8	-1.6
Mean Putamen Volume	0.1	0.2	0.6	-0.1	0.1	-0.1	0.8
Fasting Glucose	4.8	5.7	9.4	-2.8	1.5	-3.1	-1.9
HbA1C	1.0	1.1	2.7	-1.6	-0.0	-0.7	-1.2
HDL Cholesterol	0.2	0.3	0.7	0.8	-0.3	0.2	0.7
LDL Cholesterol	7.0	11.0	22.7	3.1	-3.4	4.8	0.7
Lupus	1.2	1.8	3.8	1.2	1.1	0.7	2.0
Neuroticism (2016)	1.2	1.7	3.2	-1.8	0.6	-1.5	-1.0
Primary Biliary Cirrhosis	0.3	0.4	1.5	0.0	0.1	-0.4	1.2
Rheumatoid Arthritis	3.1	4.3	9.3	-1.6	3.1	-2.1	0.8
Schizophrenia (2014)	9.3	20.4	28.6	-4.8	5.3	-4.7	-2.8
Triglycerides	13.5	22.1	43.2	4.7	-4.5	6.6	1.7
Type 2 Diabetes (T2D) (2012)	2.5	2.9	5.0	-1.2	2.2	-2.2	0.4
Ulcerative Colitis	1.5	2.1	2.8	-1.7	1.0	-1.6	-1.5
Blood Eosinophil Count	3.5	27.1	41.6	-6.5	5.3	-5.3	-3.3
Blood Platelet Count	8.5	98.0	134.6	-9.9	11.6	-11.1	-6.0
Blood Red Count	0.1	0.6	2.3	0.1	-1.5	-0.5	0.1
Blood White Count	0.7	4.8	6.9	-2.6	2.6	-2.3	-0.7
Heel T-Score	2.3	18.0	31.7	-4.9	3.2	-5.6	-2.5
BMI	1.5	8.4	16.4	-3.2	-2.4	-1.1	-4.0
Height	1.9	37.4	58.1	6.8	0.7	6.7	7.6
Waist Hip Ratio (WHR)	0.1	0.3	1.0	-0.3	-0.1	-1.0	-0.4
Systolic Blood Pressure	0.6	2.9	6.1	0.3	2.3	-0.7	2.5
Smoking Status	1.1	2.6	3.2	-1.7	1.1	-1.8	-1.8
Allergy or Eczema	0.3	0.9	2.4	0.8	-0.6	1.6	-0.1
Cardiovascular Disease	0.7	2.2	5.5	0.7	-2.4	1.4	1.0
Hypothyroidism (self reported)	1.3	3.1	6.8	-1.3	2.6	-1.8	-0.7
Respiratory disease	0.5	1.2	3.4	-0.9	-0.7	0.0	-1.9
Type 2 Diabetes (T2D) (2018)	4.8	8.9	16.6	-3.9	1.9	-4.1	-0.7
Lung FEV1/FVC ratio	0.9	4.4	7.6	-2.0	0.4	-2.4	-2.8
Lung FVC	0.0	0.2	0.6	-0.0	0.2	-0.0	-0.8
Neuroticism	2.0	4.8	8.8	-3.0	1.7	-2.0	-1.9
Chronotype (morning person)	1.5	3.4	7.9	2.8	-0.7	2.1	1.0
Hair Pigment	0.0	1.0	2.6	-0.8	0.0	-0.8	-1.6
Tanning	0.0	0.4	0.7	-0.6	0.3	-0.6	-0.8
Hand grip strength (left)	1.2	3.1	6.0	2.5	-0.4	1.6	1.8
Number of treatments/medications taken	3.2	5.8	8.1	-2.8	1.1	-2.6	-2.7
Average weekly spirits intake	6.2	7.7	12.4	-3.3	1.0	-2.5	-3.5
Sensitivity / hurt feelings	10.1	17.3	21.3	-4.5	3.8	-4.6	-3.6
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.2	1.0	-1.8	1.0	0.4
Hearing difficulty/problems: Yes	3.1	4.7	11.6	1.9	-3.4	1.9	0.1
Relative age of first facial hair	0.2	0.4	1.1	-0.0	0.7	-1.1	0.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.6	0.2	-1.3	0.7	0.3
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.4	-0.4	-0.4	-0.6	0.5
Ever had hysterectomy (womb removed)	0.5	0.6	2.2	-0.3	0.2	-0.3	-1.5
Systolic blood pressure, automated reading	0.4	1.2	2.4	-0.1	1.5	-0.5	1.5
Eye problems/disorders: Diabetes related eye disease	1.8	2.0	4.3	-1.7	0.8	-2.1	-0.0
Angina	0.5	0.6	1.1	0.2	-1.1	0.5	-1.1
Medication for hormone replacement therapy	0.2	0.3	0.4	-0.6	0.4	-0.7	0.3
Vitamin and mineral supplements	4.4	5.9	7.7	2.7	-2.2	2.8	2.0
Supplements: Zinc	0.9	0.9	3.6	-0.4	-0.2	0.2	-1.9
Medication: Co-codamol	4.6	5.4	7.2	-2.7	2.1	-2.4	-2.0
Medication: Metformin	2.8	4.0	7.9	-2.8	0.7	-2.7	-0.4
Diabetes (father)	0.5	0.6	1.7	-1.3	0.1	-0.9	-0.2
Diabetes (mother)	5.7	7.3	12.7	-3.5	2.0	-3.6	-0.3
Severe depression (siblings)	1.7	1.9	3.2	-1.8	1.2	-1.4	-1.0
Pack years adult smoking proportion	1.9	2.9	6.5	-2.5	0.6	-1.6	-1.4
Impedance of leg (right)	5.5	26.4	42.8	-4.4	6.5	-6.0	-2.8
Leg fat-free mass (left)	3.5	18.5	29.2	3.9	-4.4	5.4	3.2
Trunk fat percentage	0.8	3.1	7.0	-2.6	0.1	-0.6	-2.2
Hand grip strength (right)	1.0	2.6	4.8	2.2	-0.8	1.4	1.7
Townsend deprivation index at recruitment	3.6	5.1	15.5	1.2	-3.9	1.9	-0.1
Current tobacco smoking	3.6	5.9	7.6	-2.8	1.7	-2.5	-2.6
Average weekly fortified wine intake	0.1	0.1	0.2	-0.2	-0.5	-0.0	-0.0
Maternal smoking around birth	6.8	9.8	16.4	-3.9	2.6	-4.0	-0.9
Fed-up feelings	3.2	5.9	9.7	-3.1	1.1	-2.6	-2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	-0.9	-0.4	-0.6	-0.4
Relative age voice broke	0.6	0.9	2.5	0.6	0.7	0.3	1.6
Taking other prescription medications	8.6	13.3	18.8	-4.3	2.5	-4.1	-3.4
Age when periods started (menarche)	1.2	2.8	4.7	-1.3	2.2	-1.7	1.4
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	0.9	-0.9	0.9	-0.9	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	3.9	-2.0	0.6	-1.6	0.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.4	0.5	-0.0	-0.0
Qualifications: CSEs or equivalent	0.9	1.1	2.8	-1.7	0.5	-1.1	-0.6
Serious illness, injury or assault to yourself	0.3	0.4	1.0	-0.6	-1.0	0.1	-0.5
High blood pressure	0.1	0.2	0.4	-0.6	-0.1	-0.6	0.4
Hayfever, allergic rhinitis or eczema	0.7	1.5	3.3	1.5	-0.5	1.8	0.6
Multivitamins +/- minerals	1.3	1.6	2.7	-1.6	1.1	-1.5	-0.4
Stomach or abdominal pain in last month	6.3	7.9	12.0	-3.5	2.0	-3.1	-2.4
Supplements: Glucosamine	1.9	2.5	3.9	2.0	-1.0	1.6	1.6
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	1.9	-0.7	-1.2	0.7	-1.4
Medication: Atenolol	0.4	0.5	1.0	-0.1	-0.9	0.3	1.0
Medication: Levothyroxine sodium	2.4	4.0	7.5	-1.9	2.7	-2.2	-0.5
Sitting height	1.0	7.1	13.6	2.5	1.7	2.4	3.7
Chronic bronchitis/emphysema (father)	0.3	0.4	1.0	0.3	-1.0	0.7	-0.3
High blood pressure (mother)	1.0	1.4	4.2	-0.7	2.0	-0.8	0.5
Body mass index (BMI)	1.4	6.2	10.2	-3.2	-1.8	-1.3	-3.1
Impedance of leg (left)	6.0	29.2	49.8	-4.6	7.1	-6.2	-2.6
Leg predicted mass (left)	3.5	18.5	29.2	3.9	-4.4	5.4	3.2
Trunk fat mass	0.3	1.2	2.6	-1.6	-0.9	0.5	-1.2
Waist circumference	0.7	2.4	4.5	-1.7	-2.1	-0.2	-1.4
Number of incorrect matches in round	0.7	1.2	2.7	-0.7	0.2	-1.2	-1.7
Past tobacco smoking	0.1	0.2	0.7	0.0	0.2	-0.0	-0.9
Alcohol usually taken with meals	0.6	1.0	2.0	1.4	1.4	0.2	0.5
Nervous feelings	1.0	1.9	3.3	-1.5	1.8	-1.2	-0.6
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	3.2	1.1	-1.8	1.3	0.4
Hearing difficulty/problems with background noise	0.3	0.6	1.4	0.0	-1.2	0.3	-0.9
Hair/balding pattern: Pattern 2	8.0	10.2	16.5	-4.1	1.6	-3.4	-3.2
Had menopause	0.1	0.1	0.4	0.1	0.0	-0.3	0.6
Had other major operations	0.5	0.6	2.0	-0.7	0.0	-0.4	-1.4
Forced vital capacity (FVC)	1.7	6.5	9.7	3.1	-0.7	3.0	2.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	1.0	-1.0	0.4	-1.0	0.3
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.6	-0.7	-1.9	0.6	-0.4
Qualifications: None of the above	6.6	14.0	19.0	-4.4	2.5	-4.1	-3.8
Financial difficulties in last 2 years	0.9	1.2	1.7	-1.3	-1.3	-0.1	-1.1
Mouth/teeth dental problems	3.1	4.8	8.3	2.7	1.1	1.6	2.9
Heart attack	0.7	0.8	1.3	-1.1	1.0	-0.4	-0.9
Allergy	0.6	1.3	2.6	-0.8	0.6	-1.6	1.3
Pain all over the body in last month	2.9	3.1	5.2	-2.3	0.8	-1.7	-2.0
Diabetes (self-reported)	1.9	2.9	6.2	-2.0	0.7	-2.5	0.8
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	3.8	2.0	-0.7	1.2	1.1
Medication: Ramipril	3.6	4.6	8.0	-2.1	2.8	-2.3	-0.9
Medication: Simvastatin	8.7	12.8	17.9	3.7	-4.0	4.2	2.1
Fluid intelligence score	2.5	5.1	7.3	2.7	-1.8	2.6	1.7
Illnesses of siblings	2.1	2.9	5.2	2.0	-1.5	2.3	0.2
Neuroticism score	1.0	2.2	3.3	-1.8	0.8	-1.1	-1.8
Weight	0.4	2.2	5.2	0.1	-2.3	1.9	0.2
Impedance of arm (right)	0.9	4.0	5.4	2.3	2.1	2.0	1.6
Arm fat percentage (right)	0.8	3.3	6.0	-2.5	-1.1	-0.3	-2.4
Trunk fat-free mass	2.7	15.2	20.3	3.8	-3.7	4.5	3.5
Hip circumference	0.3	1.2	2.1	-1.1	-1.5	0.6	-1.1
Time employed in main current job	2.1	2.4	4.0	-1.8	1.0	-1.2	-2.0
Alcohol intake versus 10 years previously	3.8	5.7	9.9	-3.1	1.3	-2.4	-2.3
Father’s age at death	1.5	2.0	3.7	1.5	1.2	0.9	1.9
Worrier / anxious feelings	2.1	4.0	4.4	-2.0	1.9	-2.0	-2.1
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.8	6.5	-2.5	0.4	-2.4	-1.7
Falls in the last year	2.7	3.7	6.0	-2.4	1.7	-1.7	-1.7
Hair/balding pattern: Pattern 3	1.5	2.2	4.8	2.2	-0.5	1.6	1.1
Number of live births	4.5	6.4	9.2	-2.7	2.3	-3.0	-1.9
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	4.5	2.1	-0.4	1.7	1.6
Pulse rate	3.5	5.9	9.4	-3.1	2.3	-2.5	-1.6
Happiness	1.4	1.7	2.8	1.1	-1.7	1.7	0.3
Noisy workplace	0.2	0.2	0.4	0.7	0.2	0.5	-0.2
Qualifications: A levels/AS levels or equivalent	4.2	9.4	15.6	3.9	-2.1	3.6	2.2
Serious illness, injury or assault of a close relative in last 2 years	6.9	7.9	12.3	2.9	-2.9	3.5	1.6
Mouth/teeth dental problems: Dentures	0.9	1.5	3.6	-1.9	0.2	-1.0	-1.1
Asthma	0.5	0.9	2.1	-0.2	-0.7	1.1	-1.4
Medication: Ibuprofen (e.g. Nurofen)	3.4	4.3	10.4	-2.2	0.3	-1.4	-3.2
Medication: Cholesterol lowering	10.6	16.5	26.7	3.9	-4.8	5.2	1.0
Depression (self-reported)	0.7	0.9	2.4	-1.6	-0.8	-0.6	-0.2
Medication: Lansoprazole	3.1	3.5	5.9	-2.4	0.2	-2.2	-1.8
Prospective memory result	2.4	3.0	4.2	-1.6	2.0	-1.8	-1.3
Lung cancer (father)	2.1	2.4	4.1	-1.8	0.6	-1.4	-2.0
Illnesses of mother	1.1	1.3	3.3	1.8	-0.5	1.3	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.6	8.2	2.9	-0.7	2.6	1.8
Pulse wave Arterial Stiffness index	1.9	2.2	3.6	-1.9	1.4	-1.8	-0.4
Impedance of arm (left)	0.9	4.2	5.0	2.2	2.1	1.9	2.0
Arm fat mass (right)	0.5	2.1	3.4	-1.6	-1.8	0.4	-1.5
Trunk predicted mass	2.6	14.6	19.6	3.7	-3.6	4.4	3.5
Standing height	3.8	37.2	51.1	7.0	-1.4	6.9	7.2
Length of working week for main job	0.6	0.7	1.3	-1.1	0.0	-0.4	-1.1
Exposure to tobacco smoke at home	2.9	3.3	6.5	-2.5	1.2	-2.2	-0.5
Breastfed as a baby	1.6	2.0	3.1	1.6	1.1	0.9	1.8
Tense / ‘highly strung’	0.3	0.4	0.7	-0.7	0.8	-0.6	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.6	-1.3	-0.7	-0.2	-0.4
Hair/balding pattern: Pattern 4	0.2	0.6	1.7	-0.1	-0.8	0.3	-1.3
Birth weight of first child	3.0	5.5	9.7	2.5	-1.6	3.1	1.9
Peak expiratory flow (PEF)	1.2	2.8	4.0	1.8	-1.6	2.0	1.1
Pulse wave reflection index	0.6	0.8	1.8	-0.6	-0.7	-0.8	-1.3
Ever highly irritable/argumentative for 2 days	1.2	1.4	3.3	-1.8	1.0	-0.9	-0.7
Loud music exposure frequency	0.2	0.2	0.4	0.6	0.4	0.3	-0.6
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	1.9	1.1	0.6	1.3	1.4
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	9.6	0.4	-3.1	0.8	-0.6
Blood clot in the leg (DVT)	0.2	0.2	0.4	-0.2	0.6	-0.5	-0.4
Medication: Paracetamol	8.4	13.9	19.3	-4.4	2.5	-3.6	-4.2
Headache pain in last month	6.5	11.2	21.5	-3.9	0.9	-2.7	-4.6
Medication for cholesterol, blood pressure or diabetes	1.9	3.2	5.9	-1.5	2.4	-2.0	-0.6
Glaucoma (self-reported)	0.5	0.6	1.1	1.1	-0.6	0.8	0.6
Gout (self-reported)	0.7	1.0	1.8	-1.0	1.2	-1.3	-0.1
Hypothyroidism/myxoedema (self-reported)	2.3	4.5	8.4	-1.8	2.9	-2.3	-1.1
Medication: Amlodipine	2.3	3.2	7.1	1.8	-0.6	1.4	2.7
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.4	-1.0	-0.2	-0.6	-1.2
Birth weight	3.2	7.0	10.6	3.1	-0.8	2.6	3.2
Chronic bronchitis/emphysema (mother)	1.8	2.1	3.8	-1.9	-0.7	-1.2	-1.7
High blood pressure (siblings)	0.4	0.6	0.8	-0.1	0.9	-0.8	0.9
Forced vital capacity (FVC), Best measure	2.6	9.5	14.3	3.8	-0.8	3.7	3.1
Body fat percentage	1.8	7.0	14.3	-3.8	0.5	-1.9	-3.2
Leg fat percentage (right)	6.2	22.3	36.0	-6.0	1.7	-4.7	-5.3
Arm fat-free mass (right)	0.8	4.3	6.2	1.4	-2.5	2.2	2.0
Exposure to tobacco smoke outside home	0.1	0.2	0.3	-0.1	-0.6	0.4	0.4
Comparative body size at age 10	5.4	14.9	21.5	4.0	-4.6	4.3	1.9
Number of full brothers	0.3	0.4	1.1	-0.6	1.1	-0.4	-0.3
Worry too long after embarrassment	0.5	0.9	2.6	-0.9	0.6	-1.6	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.1	-0.5	-1.0	-0.4	-0.3
Wheeze or whistling in the chest in last year	1.6	2.8	4.2	-2.1	0.3	-1.7	-2.0
Number of children fathered	2.1	2.4	4.7	-2.2	0.3	-1.2	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	3.9	-1.2	2.0	-1.6	-0.7
Age at first live birth	10.1	17.8	31.5	5.6	-2.5	4.8	3.3
Pulse wave peak to peak time	2.7	3.1	5.3	2.3	-1.3	2.2	0.9
Health satisfaction	1.0	1.4	2.4	-0.9	-1.5	-0.2	-1.5
Shortness of breath walking on level ground	0.7	0.8	1.8	-1.4	0.0	-0.9	-0.7
Qualifications: College or University degree	4.2	13.2	24.2	4.9	-2.5	3.9	2.6
Eye problems/disorders: None of the above	0.9	1.0	1.4	0.9	-0.9	1.2	1.0
Mouth/teeth dental problems: Loose teeth	0.9	1.0	1.8	-1.3	0.7	-1.3	-0.4
Emphysema/chronic bronchitis	1.7	1.9	5.9	-0.6	0.7	-0.8	-2.4
Medication for pain relief, constipation, heartburn	4.2	7.1	13.3	3.2	-0.5	2.1	3.6
Neck or shoulder pain in last month	3.3	4.8	7.7	-2.8	2.2	-2.2	-1.1
Medication: Blood pressure	0.2	0.4	1.1	-1.0	-0.1	-0.6	-0.0
Angina (self-reported)	0.5	0.6	1.2	0.2	-1.1	0.5	-1.0
Migraine (self-reported)	3.3	4.1	10.4	-2.3	-0.9	-0.4	-3.2
Medication: Ibuprofen	4.7	5.6	10.8	-2.8	0.7	-1.9	-3.3
Medication: Allopurinol	1.3	1.8	3.2	-1.4	1.3	-1.8	-0.4
Medication: Omeprazole	0.8	1.0	2.1	-0.2	-1.3	-0.1	-1.5
Medication: Seretide 50 evohaler	0.3	0.3	1.2	0.2	0.0	0.3	1.1
Mean time to correctly identify matches	0.5	1.0	3.4	-0.1	-0.8	0.2	-1.9
Heart disease (mother)	1.3	1.6	3.0	0.8	-1.7	1.6	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.8	3.3	6.9	1.8	-2.6	1.8	0.4
Whole body fat mass	0.4	1.8	3.9	-2.0	-1.0	0.1	-1.6
Leg fat mass (right)	1.6	6.2	12.9	-3.6	-0.3	-1.9	-2.9
Arm predicted mass (right)	0.8	4.2	6.5	1.4	-2.6	2.2	1.9
Pulse rate, automated reading	1.0	3.4	4.2	-2.1	2.0	-1.5	-1.7
Alcohol intake frequency.	1.3	3.1	4.8	-1.9	1.1	-1.6	-2.2
Comparative height size at age 10	4.1	22.7	35.4	6.0	-2.8	5.8	3.8
Number of full sisters	1.6	1.9	3.4	-1.4	1.8	-1.5	0.1
Suffer from ‘nerves’	0.4	0.6	1.9	-1.4	0.4	-0.6	-0.3
Overall health rating	4.8	10.2	19.4	-4.4	1.1	-3.3	-3.0
Chest pain or discomfort	0.4	0.5	0.8	-0.7	-0.6	-0.9	-0.7
Had major operations	3.3	3.9	7.0	1.5	-2.6	2.0	1.5
Age at last live birth	5.2	7.6	14.8	3.9	-1.8	2.9	2.1
Family relationship satisfaction	0.6	0.7	2.1	-0.3	-0.6	-0.3	-1.5
Leg pain on walking	0.3	0.4	0.9	-1.0	0.1	-0.7	0.3
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	3.8	-1.5	0.8	-1.7	-1.9
Commuting to job workplace: Car/motor vehicle	1.5	1.7	2.4	-1.2	1.5	-1.1	-1.3
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.5	0.2	1.6	-0.8	-0.0
Medication: Aspirin	0.3	0.4	1.3	0.4	-1.1	0.5	0.0
Supplements: Vitamin C	1.7	2.0	4.0	-2.0	0.8	-1.3	-1.3
Knee pain experienced in last month	0.5	0.8	2.1	-1.5	0.0	-0.7	-0.7
Hypertension (Self-reported)	0.2	0.6	1.2	-1.1	0.1	-1.1	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	2.1	-1.4	-0.5	-0.9	0.5
Illnesses of father: Heart disease	7.4	10.3	12.9	3.3	-3.6	3.5	2.1
Illnesses of siblings: Diabetes	10.0	12.3	19.1	-4.2	3.1	-4.4	-1.7
Smoking status: Previous	0.2	0.3	0.8	-0.0	-0.5	0.1	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	2.1	1.0	1.0	1.3	1.5
Whole body fat-free mass	2.9	16.4	23.6	3.8	-4.0	4.9	3.3
Leg fat-free mass (right)	4.1	21.9	34.3	4.4	-4.6	5.9	3.6
Arm fat percentage (left)	0.8	3.0	6.0	-2.5	-1.2	-0.3	-2.2
Average weekly red wine intake	0.5	0.8	2.1	0.9	1.5	-0.3	0.4
Handedness (chirality/laterality): Left-handed	2.4	2.9	4.5	2.0	-0.5	1.6	2.1
Mood swings	0.5	1.0	2.0	-1.4	0.7	-0.6	-1.1
Loneliness, isolation	3.5	4.9	8.7	-2.9	0.5	-2.3	-2.3
Long-standing illness, disability or infirmity	1.1	1.7	3.2	-1.8	-1.4	-1.1	-0.7
Ever had bowel cancer screening	1.1	1.3	2.3	-1.5	0.9	-1.3	-0.7
Diabetes diagnosed by doctor	3.2	5.3	11.1	-2.8	1.2	-3.3	0.9
Ever had stillbirth, spontaneous miscarriage or termination	2.9	3.1	4.2	-1.8	1.8	-2.1	-1.2
Friendships satisfaction	0.1	0.2	0.4	0.6	0.6	0.1	-0.2
Qualifications: nursing, teaching	4.4	6.9	8.9	3.0	-2.9	2.8	1.7
Commuting to job workplace: Walk	1.5	1.7	2.7	1.6	-1.3	1.2	1.0
Eye problems/disorders: Cataract	0.7	0.8	1.1	-0.8	1.1	-1.0	-0.6
Mouth/teeth dental problems: Mouth ulcers	3.8	6.1	8.1	-2.8	2.3	-2.8	-1.8
Medication for cholesterol	0.4	0.6	1.0	0.8	-0.9	1.0	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.4	4.0	5.4	-2.3	2.2	-2.1	-1.2
Back pain experienced in last month	0.5	0.7	1.3	-0.2	-1.1	0.5	-1.1
Mineral and other dietary supplements	1.9	2.5	5.3	-1.5	1.1	-1.1	-2.3
Breast cancer (self-reported)	2.5	2.9	4.2	-1.9	1.6	-1.2	-2.0
Asthma (self-reported)	0.4	0.9	2.4	-0.4	-0.6	0.8	-1.5
Osteoporosis (self-reported)	0.6	0.7	1.0	-0.6	0.8	-1.0	-1.0
Osteoarthritis (self-reported)	2.9	3.8	7.3	-2.7	0.6	-1.8	-2.1
Medication: Aspirin	0.5	0.6	2.0	0.4	-1.4	0.5	0.2
Medication: Gliclazide	3.7	4.2	9.7	-2.0	1.5	-3.1	-1.0
Illnesses of father: None of the above (group 1)	2.8	3.4	5.3	-1.8	2.3	-2.2	-0.4
Smoking status: Current	3.8	6.1	7.6	-2.8	1.8	-2.6	-2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.0	1.0	-1.0	0.6	0.2
Whole body water mass	2.9	16.6	23.7	3.8	-4.1	4.9	3.3
Leg predicted mass (right)	4.2	22.2	34.4	4.4	-4.7	5.9	3.6
Arm fat mass (left)	0.5	2.0	3.3	-1.6	-1.8	0.4	-1.4
Number of self-reported non-cancer illnesses	1.9	3.4	7.7	-2.8	-0.4	-1.6	-1.7
Average weekly champagne plus white wine intake	2.6	3.6	6.3	2.5	-0.8	2.2	1.6
Miserableness	2.0	3.5	11.6	-1.4	-0.1	-0.6	-3.4
Guilty feelings	0.9	1.3	3.7	0.1	-1.9	-0.1	-1.2
Wears glasses or contact lenses	0.6	0.6	0.9	-0.7	0.9	-0.5	0.9
Ever taken oral contraceptive pill	0.6	0.7	1.2	0.2	-1.1	0.3	-1.1
Hearing aid user	0.2	0.2	0.5	-0.6	-0.7	0.2	0.1
Mother’s age at death	4.0	5.0	7.1	2.7	-2.4	2.7	-0.4
Financial situation satisfaction	2.7	3.3	5.2	1.7	-2.3	2.0	0.9
Tinnitus: Yes, now most or all of the time	1.6	1.9	4.1	-2.0	0.8	-1.4	-1.0
Commuting to job workplace: Public transport	1.3	1.5	2.9	0.9	-1.7	1.3	0.7
Eye problems/disorders: Glaucoma	1.5	1.8	3.2	1.8	-1.3	1.5	0.2
Medication: Blood pressure	0.7	1.3	2.3	-1.0	1.4	-1.5	-0.1
Pain type(s) experienced in last month: Hip pain	3.5	4.4	5.5	-1.9	1.7	-2.3	-2.3
Supplements: Fish oil (including cod liver oil)	2.1	2.7	6.0	1.6	-1.0	1.1	2.4
High cholesterol (Self-reported)	14.0	24.9	37.1	4.6	-5.8	6.1	2.9
Medication: Bendroflumethiazide	0.7	1.0	1.7	-0.9	0.3	-1.2	-1.3
Medication: Paracetamol	4.7	7.3	10.4	-3.1	1.8	-2.4	-3.2
Medication: Lisinopril	0.7	1.0	1.9	0.6	-1.4	0.8	0.9
Medication: Atorvastatin	5.9	7.3	13.2	2.0	-3.2	3.6	1.4
Illnesses of father: High blood pressure	0.1	0.2	0.5	0.2	0.1	-0.4	0.7
Alcohol drinker status: Never	1.2	1.4	3.7	0.6	-0.8	1.0	1.9
Ever smoked	0.4	0.7	1.1	1.0	-0.7	1.0	0.4
Basal metabolic rate	2.1	11.8	17.7	3.0	-3.7	4.2	2.6
Leg fat percentage (left)	6.1	21.9	36.0	-6.0	1.8	-4.7	-5.1
Arm fat-free mass (left)	0.6	3.3	5.2	1.3	-2.3	2.1	1.4
Number of operations (self-reported)	0.4	0.6	1.4	-0.4	-1.2	0.6	-0.8
Average weekly beer plus cider intake	0.7	1.0	1.7	-1.3	0.9	-1.3	-0.0
Irritability	0.4	0.7	1.7	-0.6	1.3	0.6	-0.3
Risk taking	2.2	3.2	5.3	-2.3	1.8	-1.9	-0.9
Ever had prostate specific antigen (PSA) test	0.9	1.0	3.0	-0.5	-0.8	-0.2	-1.7
Fractured/broken bones in last 5 years	0.7	0.9	3.5	-0.0	0.1	0.3	1.9
Age started oral contraceptive pill	0.3	0.3	1.3	0.3	1.1	0.2	-0.0
Diastolic blood pressure, automated reading	2.9	9.1	14.5	-3.2	2.7	-3.8	-2.0
Ever depressed for a whole week	0.5	0.7	2.0	-0.2	-1.4	0.7	0.3
Unable to work because of sickness or disability	2.9	3.7	9.4	-3.1	0.7	-2.2	-0.0
Commuting to job workplace: Cycle	2.3	2.7	4.5	2.1	-1.3	2.1	0.6
Myopia	3.7	5.3	11.2	-2.0	3.3	-2.4	-0.4
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.8	0.9	0.3	0.7	-0.2
Cholesterol lowering medication	2.0	3.0	4.5	1.6	-1.3	1.8	2.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.6	-0.4	-1.3	-0.1	-0.5
Pain experienced in last month	4.1	6.8	11.4	3.4	-0.6	2.1	3.3
Supplements: Calcium	3.1	3.4	5.2	-2.0	2.3	-1.9	-0.9
Basal cell carcinoma (self-reported)	0.4	0.5	1.1	-0.6	0.4	-0.6	1.1
Heart attack/myocardial infarction (self-reported)	0.5	0.6	0.9	-0.9	1.0	-0.2	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.1	0.5	-0.3	-0.4
Heart disease (siblings)	1.8	2.3	3.8	0.8	-1.7	1.3	2.0
Alcohol drinker status: Previous	2.0	2.3	3.4	-1.9	1.5	-1.8	-0.6
Pack years of smoking	1.3	2.0	5.1	-2.3	0.2	-1.2	-1.1
Impedance of whole body	1.8	9.0	27.9	-1.4	5.3	-2.4	-0.5
Leg fat mass (left)	1.5	5.9	12.8	-3.6	-0.3	-1.8	-2.8
Arm predicted mass (left)	0.6	3.1	5.2	1.2	-2.3	2.1	1.3