Hub : Traits :

Age at first live birth

179 significantly associated models · 33 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	2	173245680	174820750	1	1	1.6e-07	2.4e-08	2.5e-02	84	MLTK
2	2	214892809	216364035	1	1	7.7e-09	5.9e-08	3.5e-01	97	BARD1
3	3	48268509	51377300	23	2	6.0e-17	4.0e-17	1.9e-02	92	ARIH2 RBM6
4	8	86841229	88271452	1	1	1.8e-07	1.4e-08	6.2e-05	50	CPNE3
5	10	118396138	119123139	1	1	1.1e-07	2.8e-07	4.7e-01	98	KIAA1598
6	17	17986955	18325085	1	1	2.0e-07	2.8e-06	5.6e-01	98	SHMT1
7	19	11938262	13358672	1	1	5.4e-08	8.2e-05	1.7e-04	8	ZNF564
8	19	18333894	20313262	4	1	1.5e-08	3.2e-08	3.7e-02	86	SUGP1

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Age at last live birth	13.00	4	1	2.2	1.00	0.00402	ARIH2 MLTK RBM6 SUGP1
Qualifications: College or University degree	9.65	6	3	6.7	0.98	0.00080	ARIH2 CPNE3 RBM6 SHMT1 SUGP1 ZNF564
Age at First Birth	9.45	3	1	2.2	0.00	1.00000	ARIH2 KIAA1598 RBM6
Qualifications: A levels/AS levels or equivalent	8.27	4	1	2.2	0.99	0.00592	ARIH2 CPNE3 RBM6 SUGP1
Qualifications: None of the above	7.68	5	2	4.4	-0.99	0.00166	ARIH2 BARD1 CPNE3 RBM6 SUGP1
Body mass index (BMI)	7.05	4	3	6.7	-0.97	0.03179	ARIH2 CPNE3 KIAA1598 RBM6
Leg fat percentage (left)	6.86	5	5	11.1	-0.99	0.00072	ARIH2 CPNE3 KIAA1598 RBM6 SUGP1
Leg fat percentage (right)	6.69	5	3	6.7	-0.99	0.00101	ARIH2 CPNE3 KIAA1598 RBM6 SUGP1
Leg fat mass (left)	6.00	4	2	4.4	-0.97	0.02677	ARIH2 CPNE3 KIAA1598 RBM6
BMI	5.94	5	2	4.4	-0.94	0.01615	ARIH2 CPNE3 KIAA1598 MLTK RBM6
Leg fat mass (right)	5.94	4	2	4.4	-0.97	0.02951	ARIH2 CPNE3 KIAA1598 RBM6
Impedance of arm (left)	5.76	3	2	4.4	0.00	1.00000	ARIH2 RBM6 SUGP1
Impedance of arm (right)	5.63	3	2	4.4	0.00	1.00000	ARIH2 RBM6 SUGP1
Number of live births	5.52	2	0	0.0	0.00	1.00000	KIAA1598 RBM6
Intelligence (Savage-Jansen 2018)	4.98	2	1	2.2	0.00	1.00000	ARIH2 RBM6
Arm fat mass (right)	4.90	3	2	4.4	0.00	1.00000	CPNE3 KIAA1598 RBM6
Smoking Status	4.77	4	0	0.0	-0.98	0.01802	ARIH2 KIAA1598 MLTK RBM6
Arm fat mass (left)	4.76	3	2	4.4	0.00	1.00000	CPNE3 KIAA1598 RBM6
Exposure to tobacco smoke at home	4.74	1	0	0.0	0.00	1.00000	RBM6
Medication: Co-codamol	4.73	1	0	0.0	0.00	1.00000	RBM6
Ever highly irritable/argumentative for 2 days	4.69	1	1	2.2	0.00	1.00000	RBM6
Maternal smoking around birth	4.64	1	1	2.2	0.00	1.00000	SUGP1
Townsend deprivation index at recruitment	4.54	2	0	0.0	0.00	1.00000	ARIH2 MLTK
Verbal and Numeric Reasoning (VNR)	4.51	1	1	2.2	0.00	1.00000	RBM6
Miserableness	4.51	2	1	2.2	0.00	1.00000	ARIH2 RBM6
Fluid intelligence score	4.49	1	1	2.2	0.00	1.00000	RBM6
Impedance of whole body	4.49	3	2	4.4	0.00	1.00000	ARIH2 KIAA1598 RBM6
Overall health rating	4.45	3	1	2.2	0.00	1.00000	ARIH2 RBM6 SUGP1
Arm fat percentage (right)	4.42	3	2	4.4	0.00	1.00000	CPNE3 KIAA1598 RBM6
Mouth/teeth dental problems: Dentures	4.41	1	1	2.2	0.00	1.00000	RBM6
Depressed Affect (Nagel 2018)	4.36	2	0	0.0	0.00	1.00000	ARIH2 RBM6
Whole body fat mass	4.33	2	2	4.4	0.00	1.00000	KIAA1598 RBM6
Waist circumference	4.22	2	2	4.4	0.00	1.00000	KIAA1598 RBM6
Arm fat percentage (left)	4.20	3	2	4.4	0.00	1.00000	CPNE3 KIAA1598 RBM6
Alcohol intake frequency.	4.13	2	0	0.0	0.00	1.00000	CPNE3 RBM6
Age started oral contraceptive pill	4.12	1	0	0.0	0.00	1.00000	ARIH2
Body fat percentage	3.88	3	2	4.4	0.00	1.00000	CPNE3 KIAA1598 RBM6
Fed-up feelings	3.70	2	0	0.0	0.00	1.00000	ARIH2 RBM6
Mood swings	3.70	2	0	0.0	0.00	1.00000	ARIH2 RBM6
Wheeze or whistling in the chest in last year	3.53	1	1	2.2	0.00	1.00000	RBM6
Weight	3.44	3	2	4.4	0.00	1.00000	KIAA1598 RBM6 SHMT1
Number of full brothers	3.44	1	0	0.0	0.00	1.00000	RBM6
Qualifications: O levels/GCSEs or equivalent	3.41	2	0	0.0	0.00	1.00000	ARIH2 RBM6
Irritability	3.37	1	0	0.0	0.00	1.00000	ARIH2
Exposure to tobacco smoke outside home	3.32	1	0	0.0	0.00	1.00000	RBM6
Trunk fat mass	3.21	3	2	4.4	0.00	1.00000	KIAA1598 RBM6 SHMT1
Pack years adult smoking proportion	3.16	1	0	0.0	0.00	1.00000	ARIH2
Number of full sisters	3.15	1	0	0.0	0.00	1.00000	ARIH2
Hip circumference	3.07	2	2	4.4	0.00	1.00000	KIAA1598 RBM6
Number of treatments/medications taken	3.05	1	0	0.0	0.00	1.00000	RBM6
Financial difficulties in last 2 years	3.03	1	0	0.0	0.00	1.00000	KIAA1598
Medication for pain relief, constipation, heartburn	2.97	2	0	0.0	0.00	1.00000	ARIH2 SUGP1
Forced vital capacity (FVC), Best measure	2.87	3	0	0.0	0.00	1.00000	ARIH2 BARD1 RBM6
Pain experienced in last month	2.85	1	0	0.0	0.00	1.00000	RBM6
Comparative height size at age 10	2.80	4	2	4.4	0.57	0.42662	ARIH2 RBM6 SHMT1 SUGP1
Medication: Paracetamol	2.76	1	0	0.0	0.00	1.00000	SUGP1
Taking other prescription medications	2.73	1	0	0.0	0.00	1.00000	RBM6
Trunk fat percentage	2.72	2	1	2.2	0.00	1.00000	KIAA1598 RBM6
Standing height	2.67	4	4	8.9	0.61	0.38584	ARIH2 RBM6 SHMT1 SUGP1
Past tobacco smoking	2.55	1	0	0.0	0.00	1.00000	MLTK
Forced expiratory volume in 1-second (FEV1), Best measure	2.54	2	0	0.0	0.00	1.00000	ARIH2 RBM6
Impedance of leg (left)	2.52	1	1	2.2	0.00	1.00000	RBM6
Pack years of smoking	2.52	1	0	0.0	0.00	1.00000	ARIH2
Height	2.51	5	5	11.1	0.63	0.25807	ARIH2 CPNE3 RBM6 SHMT1 SUGP1
Forced vital capacity (FVC)	2.51	3	0	0.0	0.00	1.00000	ARIH2 BARD1 RBM6
Ulcerative Colitis (UC)	2.49	1	1	2.2	0.00	1.00000	RBM6
Neuroticism (Nagel 2018)	2.48	1	0	0.0	0.00	1.00000	SHMT1
Chronic bronchitis/emphysema (mother)	2.47	1	0	0.0	0.00	1.00000	RBM6
Impedance of leg (right)	2.45	2	1	2.2	0.00	1.00000	ARIH2 RBM6
Average weekly beer plus cider intake	2.45	1	0	0.0	0.00	1.00000	RBM6
Arm fat-free mass (left)	2.43	2	1	2.2	0.00	1.00000	KIAA1598 RBM6
Diastolic blood pressure, automated reading	2.40	2	0	0.0	0.00	1.00000	MLTK SUGP1
Arm predicted mass (left)	2.40	2	1	2.2	0.00	1.00000	KIAA1598 RBM6
Triglycerides	2.39	1	0	0.0	0.00	1.00000	SUGP1
Forced expiratory volume in 1-second (FEV1)	2.36	2	0	0.0	0.00	1.00000	ARIH2 RBM6
Neuroticism	2.27	2	0	0.0	0.00	1.00000	RBM6 SHMT1
Medication: Paracetamol	2.23	1	0	0.0	0.00	1.00000	SUGP1
Irritable Bowel Disease (IBD)	2.21	1	0	0.0	0.00	1.00000	RBM6
Waist Hip Ratio (WHR)	2.19	2	1	2.2	0.00	1.00000	ARIH2 SHMT1
Ulcerative Colitis	2.18	1	0	0.0	0.00	1.00000	RBM6
Arm predicted mass (right)	2.18	2	1	2.2	0.00	1.00000	KIAA1598 RBM6
Average weekly red wine intake	2.18	1	0	0.0	0.00	1.00000	RBM6
Basal metabolic rate	2.16	3	1	2.2	0.00	1.00000	KIAA1598 RBM6 SHMT1
Ever smoked	2.10	1	0	0.0	0.00	1.00000	KIAA1598
Arm fat-free mass (right)	2.08	2	1	2.2	0.00	1.00000	KIAA1598 RBM6
Number of operations (self-reported)	2.06	1	0	0.0	0.00	1.00000	RBM6
Systolic blood pressure, automated reading	2.04	2	1	2.2	0.00	1.00000	ARIH2 MLTK
Leg fat-free mass (left)	2.04	2	1	2.2	0.00	1.00000	KIAA1598 RBM6
Leg predicted mass (left)	2.02	2	1	2.2	0.00	1.00000	KIAA1598 RBM6
Hayfever, allergic rhinitis or eczema	1.99	1	0	0.0	0.00	1.00000	ARIH2
Mean Putamen Volume	1.95	1	0	0.0	0.00	1.00000	KIAA1598
Whole body water mass	1.79	2	1	2.2	0.00	1.00000	KIAA1598 RBM6
Blood Eosinophil Count	1.76	2	1	2.2	0.00	1.00000	ARIH2 SUGP1
Whole body fat-free mass	1.76	2	1	2.2	0.00	1.00000	KIAA1598 RBM6
Age when periods started (menarche)	1.74	1	0	0.0	0.00	1.00000	CPNE3
Guilty feelings	1.74	1	0	0.0	0.00	1.00000	RBM6
Leg fat-free mass (right)	1.69	2	1	2.2	0.00	1.00000	KIAA1598 RBM6
Type 2 Diabetes (T2D) (2018)	1.68	1	0	0.0	0.00	1.00000	SUGP1
Leg predicted mass (right)	1.68	2	1	2.2	0.00	1.00000	KIAA1598 RBM6
LDL Cholesterol	1.59	1	0	0.0	0.00	1.00000	SUGP1
Trunk fat-free mass	1.56	3	1	2.2	0.00	1.00000	KIAA1598 RBM6 SHMT1
Comparative body size at age 10	1.54	2	0	0.0	0.00	1.00000	CPNE3 RBM6
Trunk predicted mass	1.53	3	1	2.2	0.00	1.00000	KIAA1598 RBM6 SHMT1
Pulse rate, automated reading	1.42	1	0	0.0	0.00	1.00000	ARIH2
High cholesterol (Self-reported)	1.40	1	0	0.0	0.00	1.00000	SUGP1
Systolic Blood Pressure	1.31	2	0	0.0	0.00	1.00000	ARIH2 MLTK
Respiratory disease	1.29	1	0	0.0	0.00	1.00000	RBM6
Vascular/heart problems diagnosed by doctor	1.20	1	0	0.0	0.00	1.00000	ARIH2
Cardiovascular Disease	1.17	1	0	0.0	0.00	1.00000	ARIH2
Lung FVC	1.17	1	0	0.0	0.00	1.00000	KIAA1598
Blood White Count	1.14	1	1	2.2	0.00	1.00000	RBM6
Lung FEV1/FVC ratio	1.12	1	1	2.2	0.00	1.00000	MLTK
Sitting height	1.05	1	1	2.2	0.00	1.00000	ARIH2
Blood Platelet Count	0.88	2	1	2.2	0.00	1.00000	SHMT1 SUGP1
Heel T-Score	0.62	1	0	0.0	0.00	1.00000	ARIH2
Blood Red Count	0.60	2	0	0.0	0.00	1.00000	SHMT1 ZNF564
Hair Pigment	0.10	1	0	0.0	0.00	1.00000	SHMT1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Cortex	2	0.193	2.1
GTEx	Brain Hippocampus	1	0.191	2.1
GTEx	Colon Sigmoid	3	0.205	2.1
GTEx	Small Intestine Terminal Ileum	1	0.217	2.1
GTEx	Brain Caudate basal ganglia	2	0.217	2.0
GTEx	Brain Cerebellar Hemisphere	4	0.269	2.0
GTEx	Brain Cerebellum	5	0.252	2.0
GTEx	Brain Frontal Cortex BA9	3	0.325	2.0
GTEx	Brain Putamen basal ganglia	1	0.160	2.0
GTEx	Heart Atrial Appendage	4	0.253	2.0
GTEx	Ovary	1	0.110	2.0
GTEx	Prostate	1	0.120	2.0
GTEx	Uterus	0	0.000	2.0
GTEx	Adipose Subcutaneous	3	0.086	1.9
GTEx	Adipose Visceral Omentum	2	0.098	1.9
GTEx	Artery Coronary	1	0.085	1.9
GTEx	Brain Hypothalamus	0	0.000	1.9
GTEx	Brain Nucleus accumbens basal ganglia	1	0.116	1.9
GTEx	Cells EBV-transformed lymphocytes	2	0.141	1.9
GTEx	Colon Transverse	3	0.145	1.9
GTEx	Esophagus Gastroesophageal Junction	3	0.208	1.9
GTEx	Esophagus Muscularis	4	0.124	1.9
GTEx	Liver	1	0.139	1.9
GTEx	Lung	4	0.139	1.9
GTEx	Pancreas	1	0.061	1.9
GTEx	Pituitary	4	0.359	1.9
GTEx	Skin Not Sun Exposed Suprapubic	4	0.163	1.9
GTEx	Spleen	4	0.283	1.9
GTEx	Stomach	2	0.138	1.9
GTEx	Thyroid	5	0.125	1.9
GTEx	Adrenal Gland	1	0.069	1.8
GTEx	Artery Aorta	3	0.101	1.8
GTEx	Artery Tibial	5	0.133	1.8
GTEx	Breast Mammary Tissue	2	0.101	1.8
GTEx	Breast Mammary Tissue (Female)	2	0.122	1.8
GTEx	Cells Transformed fibroblasts	4	0.095	1.8
GTEx	Esophagus Mucosa	5	0.151	1.8
GTEx	Heart Left Ventricle	2	0.131	1.8
GTEx	Muscle Skeletal	2	0.069	1.8
GTEx	Nerve Tibial	3	0.069	1.8
GTEx	Skin Sun Exposed Lower leg	5	0.137	1.8
GTEx	Testis	3	0.095	1.8
GTEx	Vagina	1	0.157	1.8
GTEx	Whole Blood	2	0.100	1.8
ROSMAP	Brain Pre-frontal Cortex	6	0.137	1.8
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	1	0.091	1.8
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.8
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	2	0.098	1.8
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.063	1.8
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	3	0.226	1.8
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.8
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.7
METSIM	Adipose	3	0.065	1.7
NTR	Blood	3	0.125	1.7
CommonMind	Brain Pre-frontal Cortex	5	0.093	1.7
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.7
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.7
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	3	0.110	1.7
The Cancer Genome Atlas	Brain Lower Grade Glioma	7	0.163	1.7
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	1	0.090	1.7
The Cancer Genome Atlas	Lung Adenocarcinoma	3	0.102	1.7
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	2	0.080	1.7
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	3	0.181	1.7
The Cancer Genome Atlas	Prostate Adenocarcinoma	4	0.087	1.7
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.7
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.7
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.7
The Cancer Genome Atlas	Stomach Adenocarcinoma	2	0.119	1.7
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.7
The Cancer Genome Atlas	Thyroid Carcinoma	4	0.078	1.7
YFS	Blood	3	0.065	1.6
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	1	0.060	1.6
The Cancer Genome Atlas	Breast Invasive Carcinoma	5	0.113	1.6
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	3	0.073	1.6