Hub : Traits :

Age at first live birth

179 significantly associated models · 33 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 173245680 174820750 1 1 1.6e-07 2.4e-08 2.5e-02 84 MLTK
2 2 214892809 216364035 1 1 7.7e-09 5.9e-08 3.5e-01 97 BARD1
3 3 48268509 51377300 23 2 6.0e-17 4.0e-17 1.9e-02 92 ARIH2 RBM6
4 8 86841229 88271452 1 1 1.8e-07 1.4e-08 6.2e-05 50 CPNE3
5 10 118396138 119123139 1 1 1.1e-07 2.8e-07 4.7e-01 98 KIAA1598
6 17 17986955 18325085 1 1 2.0e-07 2.8e-06 5.6e-01 98 SHMT1
7 19 11938262 13358672 1 1 5.4e-08 8.2e-05 1.7e-04 8 ZNF564
8 19 18333894 20313262 4 1 1.5e-08 3.2e-08 3.7e-02 86 SUGP1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 4.36 2 0 0.0 0.00 1.00000 ARIH2 RBM6
Intelligence (Savage-Jansen 2018) 4.98 2 1 2.2 0.00 1.00000 ARIH2 RBM6
Neuroticism (Nagel 2018) 2.48 1 0 0.0 0.00 1.00000 SHMT1
Irritable Bowel Disease (IBD) 2.21 1 0 0.0 0.00 1.00000 RBM6
Ulcerative Colitis (UC) 2.49 1 1 2.2 0.00 1.00000 RBM6
Verbal and Numeric Reasoning (VNR) 4.51 1 1 2.2 0.00 1.00000 RBM6
Age at First Birth 9.45 3 1 2.2 0.00 1.00000 ARIH2 KIAA1598 RBM6
Mean Putamen Volume 1.95 1 0 0.0 0.00 1.00000 KIAA1598
LDL Cholesterol 1.59 1 0 0.0 0.00 1.00000 SUGP1
Triglycerides 2.39 1 0 0.0 0.00 1.00000 SUGP1
Ulcerative Colitis 2.18 1 0 0.0 0.00 1.00000 RBM6
Blood Eosinophil Count 1.76 2 1 2.2 0.00 1.00000 ARIH2 SUGP1
Blood Platelet Count 0.88 2 1 2.2 0.00 1.00000 SHMT1 SUGP1
Blood Red Count 0.60 2 0 0.0 0.00 1.00000 SHMT1 ZNF564
Blood White Count 1.14 1 1 2.2 0.00 1.00000 RBM6
Heel T-Score 0.62 1 0 0.0 0.00 1.00000 ARIH2
BMI 5.94 5 2 4.4 -0.94 0.01615 ARIH2 CPNE3 KIAA1598 MLTK RBM6
Height 2.51 5 5 11.1 0.63 0.25807 ARIH2 CPNE3 RBM6 SHMT1 SUGP1
Waist Hip Ratio (WHR) 2.19 2 1 2.2 0.00 1.00000 ARIH2 SHMT1
Systolic Blood Pressure 1.31 2 0 0.0 0.00 1.00000 ARIH2 MLTK
Smoking Status 4.77 4 0 0.0 -0.98 0.01802 ARIH2 KIAA1598 MLTK RBM6
Cardiovascular Disease 1.17 1 0 0.0 0.00 1.00000 ARIH2
Respiratory disease 1.29 1 0 0.0 0.00 1.00000 RBM6
Type 2 Diabetes (T2D) (2018) 1.68 1 0 0.0 0.00 1.00000 SUGP1
Lung FEV1/FVC ratio 1.12 1 1 2.2 0.00 1.00000 MLTK
Lung FVC 1.17 1 0 0.0 0.00 1.00000 KIAA1598
Neuroticism 2.27 2 0 0.0 0.00 1.00000 RBM6 SHMT1
Hair Pigment 0.10 1 0 0.0 0.00 1.00000 SHMT1
Number of treatments/medications taken 3.05 1 0 0.0 0.00 1.00000 RBM6
Systolic blood pressure, automated reading 2.04 2 1 2.2 0.00 1.00000 ARIH2 MLTK
Medication: Co-codamol 4.73 1 0 0.0 0.00 1.00000 RBM6
Pack years adult smoking proportion 3.16 1 0 0.0 0.00 1.00000 ARIH2
Impedance of leg (right) 2.45 2 1 2.2 0.00 1.00000 ARIH2 RBM6
Leg fat-free mass (left) 2.04 2 1 2.2 0.00 1.00000 KIAA1598 RBM6
Trunk fat percentage 2.72 2 1 2.2 0.00 1.00000 KIAA1598 RBM6
Townsend deprivation index at recruitment 4.54 2 0 0.0 0.00 1.00000 ARIH2 MLTK
Maternal smoking around birth 4.64 1 1 2.2 0.00 1.00000 SUGP1
Fed-up feelings 3.70 2 0 0.0 0.00 1.00000 ARIH2 RBM6
Taking other prescription medications 2.73 1 0 0.0 0.00 1.00000 RBM6
Age when periods started (menarche) 1.74 1 0 0.0 0.00 1.00000 CPNE3
Hayfever, allergic rhinitis or eczema 1.99 1 0 0.0 0.00 1.00000 ARIH2
Sitting height 1.05 1 1 2.2 0.00 1.00000 ARIH2
Body mass index (BMI) 7.05 4 3 6.7 -0.97 0.03179 ARIH2 CPNE3 KIAA1598 RBM6
Impedance of leg (left) 2.52 1 1 2.2 0.00 1.00000 RBM6
Leg predicted mass (left) 2.02 2 1 2.2 0.00 1.00000 KIAA1598 RBM6
Trunk fat mass 3.21 3 2 4.4 0.00 1.00000 KIAA1598 RBM6 SHMT1
Waist circumference 4.22 2 2 4.4 0.00 1.00000 KIAA1598 RBM6
Past tobacco smoking 2.55 1 0 0.0 0.00 1.00000 MLTK
Forced vital capacity (FVC) 2.51 3 0 0.0 0.00 1.00000 ARIH2 BARD1 RBM6
Qualifications: None of the above 7.68 5 2 4.4 -0.99 0.00166 ARIH2 BARD1 CPNE3 RBM6 SUGP1
Financial difficulties in last 2 years 3.03 1 0 0.0 0.00 1.00000 KIAA1598
Fluid intelligence score 4.49 1 1 2.2 0.00 1.00000 RBM6
Weight 3.44 3 2 4.4 0.00 1.00000 KIAA1598 RBM6 SHMT1
Impedance of arm (right) 5.63 3 2 4.4 0.00 1.00000 ARIH2 RBM6 SUGP1
Arm fat percentage (right) 4.42 3 2 4.4 0.00 1.00000 CPNE3 KIAA1598 RBM6
Trunk fat-free mass 1.56 3 1 2.2 0.00 1.00000 KIAA1598 RBM6 SHMT1
Hip circumference 3.07 2 2 4.4 0.00 1.00000 KIAA1598 RBM6
Number of live births 5.52 2 0 0.0 0.00 1.00000 KIAA1598 RBM6
Forced expiratory volume in 1-second (FEV1) 2.36 2 0 0.0 0.00 1.00000 ARIH2 RBM6
Qualifications: A levels/AS levels or equivalent 8.27 4 1 2.2 0.99 0.00592 ARIH2 CPNE3 RBM6 SUGP1
Mouth/teeth dental problems: Dentures 4.41 1 1 2.2 0.00 1.00000 RBM6
Forced expiratory volume in 1-second (FEV1), Best measure 2.54 2 0 0.0 0.00 1.00000 ARIH2 RBM6
Impedance of arm (left) 5.76 3 2 4.4 0.00 1.00000 ARIH2 RBM6 SUGP1
Arm fat mass (right) 4.90 3 2 4.4 0.00 1.00000 CPNE3 KIAA1598 RBM6
Trunk predicted mass 1.53 3 1 2.2 0.00 1.00000 KIAA1598 RBM6 SHMT1
Standing height 2.67 4 4 8.9 0.61 0.38584 ARIH2 RBM6 SHMT1 SUGP1
Exposure to tobacco smoke at home 4.74 1 0 0.0 0.00 1.00000 RBM6
Ever highly irritable/argumentative for 2 days 4.69 1 1 2.2 0.00 1.00000 RBM6
Qualifications: O levels/GCSEs or equivalent 3.41 2 0 0.0 0.00 1.00000 ARIH2 RBM6
Medication: Paracetamol 2.76 1 0 0.0 0.00 1.00000 SUGP1
Chronic bronchitis/emphysema (mother) 2.47 1 0 0.0 0.00 1.00000 RBM6
Forced vital capacity (FVC), Best measure 2.87 3 0 0.0 0.00 1.00000 ARIH2 BARD1 RBM6
Body fat percentage 3.88 3 2 4.4 0.00 1.00000 CPNE3 KIAA1598 RBM6
Leg fat percentage (right) 6.69 5 3 6.7 -0.99 0.00101 ARIH2 CPNE3 KIAA1598 RBM6 SUGP1
Arm fat-free mass (right) 2.08 2 1 2.2 0.00 1.00000 KIAA1598 RBM6
Exposure to tobacco smoke outside home 3.32 1 0 0.0 0.00 1.00000 RBM6
Comparative body size at age 10 1.54 2 0 0.0 0.00 1.00000 CPNE3 RBM6
Number of full brothers 3.44 1 0 0.0 0.00 1.00000 RBM6
Wheeze or whistling in the chest in last year 3.53 1 1 2.2 0.00 1.00000 RBM6
Qualifications: College or University degree 9.65 6 3 6.7 0.98 0.00080 ARIH2 CPNE3 RBM6 SHMT1 SUGP1 ZNF564
Medication for pain relief, constipation, heartburn 2.97 2 0 0.0 0.00 1.00000 ARIH2 SUGP1
Whole body fat mass 4.33 2 2 4.4 0.00 1.00000 KIAA1598 RBM6
Leg fat mass (right) 5.94 4 2 4.4 -0.97 0.02951 ARIH2 CPNE3 KIAA1598 RBM6
Arm predicted mass (right) 2.18 2 1 2.2 0.00 1.00000 KIAA1598 RBM6
Pulse rate, automated reading 1.42 1 0 0.0 0.00 1.00000 ARIH2
Alcohol intake frequency. 4.13 2 0 0.0 0.00 1.00000 CPNE3 RBM6
Comparative height size at age 10 2.80 4 2 4.4 0.57 0.42662 ARIH2 RBM6 SHMT1 SUGP1
Number of full sisters 3.15 1 0 0.0 0.00 1.00000 ARIH2
Overall health rating 4.45 3 1 2.2 0.00 1.00000 ARIH2 RBM6 SUGP1
Age at last live birth 13.00 4 1 2.2 1.00 0.00402 ARIH2 MLTK RBM6 SUGP1
Whole body fat-free mass 1.76 2 1 2.2 0.00 1.00000 KIAA1598 RBM6
Leg fat-free mass (right) 1.69 2 1 2.2 0.00 1.00000 KIAA1598 RBM6
Arm fat percentage (left) 4.20 3 2 4.4 0.00 1.00000 CPNE3 KIAA1598 RBM6
Average weekly red wine intake 2.18 1 0 0.0 0.00 1.00000 RBM6
Mood swings 3.70 2 0 0.0 0.00 1.00000 ARIH2 RBM6
Whole body water mass 1.79 2 1 2.2 0.00 1.00000 KIAA1598 RBM6
Leg predicted mass (right) 1.68 2 1 2.2 0.00 1.00000 KIAA1598 RBM6
Arm fat mass (left) 4.76 3 2 4.4 0.00 1.00000 CPNE3 KIAA1598 RBM6
Miserableness 4.51 2 1 2.2 0.00 1.00000 ARIH2 RBM6
Guilty feelings 1.74 1 0 0.0 0.00 1.00000 RBM6
High cholesterol (Self-reported) 1.40 1 0 0.0 0.00 1.00000 SUGP1
Medication: Paracetamol 2.23 1 0 0.0 0.00 1.00000 SUGP1
Ever smoked 2.10 1 0 0.0 0.00 1.00000 KIAA1598
Basal metabolic rate 2.16 3 1 2.2 0.00 1.00000 KIAA1598 RBM6 SHMT1
Leg fat percentage (left) 6.86 5 5 11.1 -0.99 0.00072 ARIH2 CPNE3 KIAA1598 RBM6 SUGP1
Arm fat-free mass (left) 2.43 2 1 2.2 0.00 1.00000 KIAA1598 RBM6
Number of operations (self-reported) 2.06 1 0 0.0 0.00 1.00000 RBM6
Average weekly beer plus cider intake 2.45 1 0 0.0 0.00 1.00000 RBM6
Irritability 3.37 1 0 0.0 0.00 1.00000 ARIH2
Age started oral contraceptive pill 4.12 1 0 0.0 0.00 1.00000 ARIH2
Diastolic blood pressure, automated reading 2.40 2 0 0.0 0.00 1.00000 MLTK SUGP1
Vascular/heart problems diagnosed by doctor 1.20 1 0 0.0 0.00 1.00000 ARIH2
Pain experienced in last month 2.85 1 0 0.0 0.00 1.00000 RBM6
Pack years of smoking 2.52 1 0 0.0 0.00 1.00000 ARIH2
Impedance of whole body 4.49 3 2 4.4 0.00 1.00000 ARIH2 KIAA1598 RBM6
Leg fat mass (left) 6.00 4 2 4.4 -0.97 0.02677 ARIH2 CPNE3 KIAA1598 RBM6
Arm predicted mass (left) 2.40 2 1 2.2 0.00 1.00000 KIAA1598 RBM6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 3 0.086 1.9
GTEx Adipose Visceral Omentum 2 0.098 1.9
GTEx Adrenal Gland 1 0.069 1.8
GTEx Artery Aorta 3 0.101 1.8
GTEx Artery Coronary 1 0.085 1.9
GTEx Artery Tibial 5 0.133 1.8
GTEx Brain Caudate basal ganglia 2 0.217 2.0
GTEx Brain Cerebellar Hemisphere 4 0.269 2.0
GTEx Brain Cerebellum 5 0.252 2.0
GTEx Brain Cortex 2 0.193 2.1
GTEx Brain Frontal Cortex BA9 3 0.325 2.0
GTEx Brain Hippocampus 1 0.191 2.1
GTEx Brain Hypothalamus 0 0.000 1.9
GTEx Brain Nucleus accumbens basal ganglia 1 0.116 1.9
GTEx Brain Putamen basal ganglia 1 0.160 2.0
GTEx Breast Mammary Tissue 2 0.101 1.8
GTEx Breast Mammary Tissue (Male) 0 0.000 1.7
GTEx Breast Mammary Tissue (Female) 2 0.122 1.8
GTEx Cells EBV-transformed lymphocytes 2 0.141 1.9
GTEx Cells Transformed fibroblasts 4 0.095 1.8
GTEx Colon Sigmoid 3 0.205 2.1
GTEx Colon Transverse 3 0.145 1.9
GTEx Esophagus Gastroesophageal Junction 3 0.208 1.9
GTEx Esophagus Mucosa 5 0.151 1.8
GTEx Esophagus Muscularis 4 0.124 1.9
GTEx Heart Atrial Appendage 4 0.253 2.0
GTEx Heart Left Ventricle 2 0.131 1.8
GTEx Liver 1 0.139 1.9
GTEx Lung 4 0.139 1.9
GTEx Muscle Skeletal 2 0.069 1.8
GTEx Nerve Tibial 3 0.069 1.8
GTEx Ovary 1 0.110 2.0
GTEx Pancreas 1 0.061 1.9
GTEx Pituitary 4 0.359 1.9
GTEx Prostate 1 0.120 2.0
GTEx Skin Not Sun Exposed Suprapubic 4 0.163 1.9
GTEx Skin Sun Exposed Lower leg 5 0.137 1.8
GTEx Small Intestine Terminal Ileum 1 0.217 2.1
GTEx Spleen 4 0.283 1.9
GTEx Stomach 2 0.138 1.9
GTEx Testis 3 0.095 1.8
GTEx Thyroid 5 0.125 1.9
GTEx Uterus 0 0.000 2.0
GTEx Vagina 1 0.157 1.8
GTEx Whole Blood 2 0.100 1.8
METSIM Adipose 3 0.065 1.7
NTR Blood 3 0.125 1.7
ROSMAP Brain Pre-frontal Cortex 6 0.137 1.8
YFS Blood 3 0.065 1.6
CommonMind Brain Pre-frontal Cortex 5 0.093 1.7
The Cancer Genome Atlas Bladder Urothelial Carcinoma 1 0.060 1.6
The Cancer Genome Atlas Breast Invasive Carcinoma 5 0.113 1.6
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 1 0.091 1.8
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.048 1.7
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.7
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.8
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 3 0.110 1.7
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 3 0.073 1.6
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 2 0.098 1.8
The Cancer Genome Atlas Brain Lower Grade Glioma 7 0.163 1.7
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 1 0.090 1.7
The Cancer Genome Atlas Lung Adenocarcinoma 3 0.102 1.7
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 2 0.080 1.7
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 1 0.063 1.8
The Cancer Genome Atlas Pancreatic Adenocarcinoma 3 0.181 1.7
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 3 0.226 1.8
The Cancer Genome Atlas Prostate Adenocarcinoma 4 0.087 1.7
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.7
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.7
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.7
The Cancer Genome Atlas Stomach Adenocarcinoma 2 0.119 1.7
The Cancer Genome Atlas Testicular Germ Cell Tumors 1 0.078 1.7
The Cancer Genome Atlas Thyroid Carcinoma 4 0.078 1.7
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.8