TWAS
hub
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Models
Genes
Traits
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Traits
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Ever used hormone-replacement therapy (HRT)
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chr1:180,228,968-181,688,483
Best TWAS P=6.94e-09 · Best GWAS P=1.2e-08 conditioned to 0.185
180.2M
180.4M
180.6M
180.8M
181M
181.2M
181.4M
181.6M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Bladder Urothelial Carcinoma
MR1
0.10
0.06
lasso
7
0.07
2.2e-06
5.7
5.8
6.9e-09
0.87
0.00
0.99
TRUE
1
CommonMind
Brain Pre-frontal Cortex
STX6
0.10
0.11
enet
12
0.11
4.9e-13
5.6
5.6
2.0e-08
0.99
0.01
0.99
FALSE
4
The Cancer Genome Atlas
Bladder Urothelial Carcinoma
STX6
0.06
0.03
enet
8
0.03
2.8e-03
4.7
5.6
2.1e-08
0.71
0.03
0.52
FALSE
2
GTEx
Liver
RP11-46A10.4
0.19
0.02
enet
15
0.06
8.9e-03
-4.3
5.4
5.9e-08
0.83
0.02
0.85
FALSE