Hub : Traits :

Ever used hormone-replacement therapy (HRT)

7 significantly associated models · 6 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 180228968 181688483 3 1 6.9e-09 1.2e-08 0.185 95 MR1
2 8 37686749 38101003 1 1 6.5e-08 3.7e-08 1.000 100 EIF4EBP1
3 19 55574907 56089353 1 1 1.0e-07 1.2e-08 0.038 87 TMEM150B
4 20 61269348 61742135 1 1 4.8e-08 4.7e-06 0.049 81 TCFL5

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Intelligence (Savage-Jansen 2018) 1.38 1 0 0.0 0.00 1.000 TCFL5
Alzheimer’s Disease (including proxy) 1.79 1 0 0.0 0.00 1.000 MR1
Breast Cancer 3.65 2 0 0.0 0.00 1.000 EIF4EBP1 TMEM150B
Lupus 2.99 1 0 0.0 0.00 1.000 MR1
Blood Red Count 0.36 1 0 0.0 0.00 1.000 TMEM150B
Height 0.35 2 0 0.0 0.00 1.000 EIF4EBP1 MR1
Lung FEV1/FVC ratio 1.59 2 0 0.0 0.00 1.000 MR1 TMEM150B
Chronotype (morning person) 1.85 1 0 0.0 0.00 1.000 EIF4EBP1
Tanning 0.30 1 0 0.0 0.00 1.000 MR1
Ever had hysterectomy (womb removed) 2.51 1 0 0.0 0.00 1.000 MR1
Medication for hormone replacement therapy 8.19 3 0 0.0 0.00 1.000 EIF4EBP1 MR1 TCFL5
Pack years adult smoking proportion 2.71 1 0 0.0 0.00 1.000 TCFL5
Hand grip strength (right) 1.30 1 0 0.0 0.00 1.000 TMEM150B
Age when periods started (menarche) 1.32 1 0 0.0 0.00 1.000 EIF4EBP1
Bilateral oophorectomy (both ovaries removed) 4.56 1 0 0.0 0.00 1.000 TMEM150B
Supplements: Glucosamine 2.15 1 0 0.0 0.00 1.000 TMEM150B
Medication: Levothyroxine sodium 2.73 1 0 0.0 0.00 1.000 TCFL5
Sitting height 0.77 2 0 0.0 0.00 1.000 MR1 TCFL5
Had menopause 20.61 4 2 4.4 0.97 0.034 EIF4EBP1 MR1 TCFL5 TMEM150B
Number of live births 1.47 1 0 0.0 0.00 1.000 MR1
Forced expiratory volume in 1-second (FEV1) 1.00 1 0 0.0 0.00 1.000 TMEM150B
Standing height 0.37 1 0 0.0 0.00 1.000 TMEM150B
Glaucoma (self-reported) 4.05 2 0 0.0 0.00 1.000 EIF4EBP1 TMEM150B
Hypothyroidism/myxoedema (self-reported) 1.88 1 0 0.0 0.00 1.000 EIF4EBP1
Forced vital capacity (FVC), Best measure 1.02 1 0 0.0 0.00 1.000 MR1
Knee pain experienced in last month 1.36 1 0 0.0 0.00 1.000 TMEM150B
Qualifications: nursing, teaching 1.99 1 0 0.0 0.00 1.000 TCFL5
Medication for cholesterol 3.08 1 0 0.0 0.00 1.000 MR1
Back pain experienced in last month 2.69 1 0 0.0 0.00 1.000 TMEM150B
Osteoarthritis (self-reported) 3.16 2 0 0.0 0.00 1.000 MR1 TMEM150B
Mother's age at death 2.70 1 0 0.0 0.00 1.000 EIF4EBP1
Commuting to job workplace: Cycle 1.98 1 0 0.0 0.00 1.000 TMEM150B
Pack years of smoking 2.59 1 0 0.0 0.00 1.000 TCFL5

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.3
GTEx Adipose Visceral Omentum 0 0.000 1.3
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 0 0.000 1.3
GTEx Artery Coronary 0 0.000 1.3
GTEx Artery Tibial 0 0.000 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.2
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.3
GTEx Brain Cortex 0 0.000 1.3
GTEx Brain Frontal Cortex BA9 0 0.000 1.2
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.2
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.3
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 0 0.000 1.3
GTEx Colon Sigmoid 0 0.000 1.4
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 1 0.139 1.4
GTEx Lung 0 0.000 1.3
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 0 0.000 1.3
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.4
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.4
GTEx Spleen 0 0.000 1.3
GTEx Stomach 0 0.000 1.3
GTEx Testis 0 0.000 1.4
GTEx Thyroid 0 0.000 1.3
GTEx Uterus 0 0.000 1.3
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.3
NTR Blood 0 0.000 1.3
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.3
CommonMind Brain Pre-frontal Cortex 1 0.019 1.3
The Cancer Genome Atlas Bladder Urothelial Carcinoma 2 0.121 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 1 0.023 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 1 0.040 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 1 0.063 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.3
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.1