Hub : Genes

MR1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2940	0.0430	0.0e+00	0.199	0.215	0.234	0.245	0.217	9.8e-24	1.2e-25	4.3e-28	1.8e-29	5.5e-26
2	GTEx	Colon Sigmoid	0.2450	0.0930	8.3e-03	0.008	NA	-0.006	NA	0.012	1.6e-01	NA	5.8e-01	NA	1.2e-01
3	GTEx	Spleen	0.6440	0.1050	3.6e-04	0.210	NA	0.148	NA	0.205	4.3e-06	NA	1.3e-04	NA	5.5e-06
4	METSIM	Adipose	0.0486	0.0209	6.8e-03	0.044	0.007	0.026	0.020	0.034	3.5e-07	2.3e-02	8.0e-05	4.9e-04	7.4e-06
5	NTR	Blood	0.0521	0.0148	6.1e-06	0.034	0.024	0.037	0.034	0.035	2.7e-11	1.8e-08	5.9e-12	3.3e-11	1.9e-11
6	YFS	Blood	0.3705	0.0354	0.0e+00	0.212	0.272	0.314	0.240	0.315	1.2e-67	3.2e-89	2.3e-105	2.2e-77	8.5e-106
7	TCGA	Bladder Urothelial Carcinoma	0.1040	0.0440	1.9e-05	0.060	0.050	0.067	NA	0.068	8.5e-06	4.6e-05	2.6e-06	NA	2.2e-06
8	TCGA	Breast Invasive Carcinoma	0.0285	0.0128	2.9e-05	0.005	0.017	0.009	NA	0.007	2.7e-02	1.9e-04	4.8e-03	NA	1.2e-02
9	TCGA	Glioblastoma Multiforme	0.2210	0.0870	8.3e-05	0.064	0.130	0.108	NA	0.086	5.2e-03	9.4e-05	3.6e-04	NA	1.4e-03
10	TCGA	Head and Neck Squamous Cell Carcinoma	0.0324	0.0159	5.1e-04	0.010	0.036	0.029	NA	0.027	2.3e-02	6.0e-05	2.9e-04	NA	4.9e-04
11	TCGA	Kidney Renal Clear Cell Carcinoma	0.1105	0.0354	1.9e-10	0.083	0.091	0.091	NA	0.088	1.4e-09	2.0e-10	2.0e-10	NA	4.1e-10
12	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0570	0.0280	6.3e-04	0.028	0.062	0.051	NA	0.048	9.8e-03	2.0e-04	6.6e-04	NA	9.4e-04
13	TCGA	Brain Lower Grade Glioma	0.0461	0.0250	4.6e-04	0.001	0.028	0.011	NA	0.010	2.3e-01	3.5e-04	1.7e-02	NA	2.3e-02
14	TCGA	Liver Hepatocellular Carcinoma	0.1300	0.0600	4.0e-04	0.077	0.072	0.090	NA	0.073	1.8e-04	2.8e-04	5.1e-05	NA	2.5e-04
15	TCGA	Lung Adenocarcinoma	0.0407	0.0192	1.2e-04	0.029	0.025	0.014	NA	0.023	2.2e-04	5.4e-04	8.2e-03	NA	9.1e-04
16	TCGA	Lung Squamous Cell Carcinoma	0.0349	0.0192	1.3e-03	0.013	0.026	0.007	NA	0.020	1.1e-02	5.9e-04	4.6e-02	NA	1.9e-03
17	TCGA	Soft Tissue Sarcoma	0.0680	0.0360	1.5e-03	0.023	0.057	0.039	NA	0.045	1.5e-02	2.5e-04	2.4e-03	NA	1.1e-03
18	TCGA	Thyroid Carcinoma	0.1010	0.0410	3.9e-07	0.048	0.076	0.081	NA	0.084	1.9e-05	7.4e-08	2.9e-08	NA	1.3e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Bipolar Disorder (2018)	0.2	0.2	1.1	1.0	0.7	-0.2	0.4	0.4	-0.3	-0.1	-0.7	-0.3	-0.4	-0.3	-0.0	-0.4	-0.6	-0.3	-0.3	-0.2	-0.9
Bipolar Disorder or Schizophrenia	0.1	0.2	0.9	0.9	1.0	0.5	0.0	-0.1	0.1	0.8	0.2	-0.0	0.3	0.4	0.1	0.5	-0.2	0.0	-0.1	-0.5	-0.5
Depressed Affect (Nagel 2018)	0.4	0.8	4.0	-1.6	-0.8	-0.8	-1.2	-2.0	0.1	-0.4	0.8	1.1	0.9	-0.2	-0.1	0.9	-0.1	0.1	0.3	-0.4	0.8
Depression (Nagel 2018)	1.8	2.8	6.7	-2.1	0.0	-1.7	-2.1	-2.6	1.2	0.8	1.3	2.1	2.1	0.7	1.8	1.7	1.2	1.7	2.0	1.5	1.1
Intelligence (Savage-Jansen 2018)	0.2	0.7	3.6	-0.6	-1.9	1.5	0.1	-0.5	-0.1	-1.3	-0.3	-0.4	-1.0	-0.4	-0.6	-1.0	-0.5	-0.5	-0.4	-0.3	-0.7
Neuroticism (Nagel 2018)	0.9	2.1	5.8	-1.7	-0.8	-0.8	-1.4	-2.4	0.8	0.3	1.5	2.1	2.1	0.8	0.9	1.7	0.9	1.4	1.4	0.6	2.0
Schizophrenia (2018)	0.2	0.3	1.2	0.3	0.4	0.8	-0.3	-0.4	0.4	1.1	0.8	0.2	0.7	0.8	0.2	1.0	0.2	0.3	0.2	-0.4	0.1
Schizophrenia vs Biploar Disorder	0.1	0.1	0.6	0.2	0.7	0.8	0.1	-0.4	-0.1	0.5	0.3	-0.2	0.4	-0.0	0.0	0.5	-0.1	0.1	-0.2	-0.2	-0.1
Worry (Nagel 2018)	0.4	0.8	2.9	-0.5	-0.8	0.3	-0.5	-1.2	0.6	0.5	0.7	1.7	1.4	0.8	0.3	1.2	0.7	0.8	0.7	-0.1	1.4
Alzheimer’s Disease (in mother)	2.1	2.5	5.2	-0.5	1.4	0.5	-1.2	-1.6	1.8	1.9	1.1	1.8	2.0	1.8	1.6	2.3	2.0	1.6	1.4	1.0	1.7
Alzheimer’s Disease (in father)	1.8	2.0	5.0	-0.8	1.9	1.2	-1.1	-1.4	1.5	1.5	0.5	2.2	1.4	1.3	1.4	1.5	1.4	1.4	1.3	1.2	1.2
Alzheimer’s Disease (including proxy)	3.8	5.5	10.1	-0.8	2.9	0.4	-1.7	-2.3	2.5	3.2	1.3	3.0	2.8	2.4	2.6	3.2	2.7	2.3	2.1	1.8	2.2
Crohns Disease (2017)	0.1	0.3	1.2	-0.0	-1.1	-0.8	0.3	0.0	0.1	-0.7	-0.1	-0.5	-1.0	0.0	-0.7	-0.7	-0.1	-0.5	-0.5	-0.4	-0.5
Irritable Bowel Disease (IBD)	0.2	0.4	1.1	0.6	-0.7	1.0	0.7	0.4	0.1	-0.2	-0.4	-0.4	-1.1	0.4	-1.0	-0.8	0.1	-0.5	-0.7	-0.6	-0.4
Ulcerative Colitis (UC)	0.4	0.7	2.9	1.5	-0.1	1.7	1.2	0.9	-0.4	0.4	-0.7	-0.5	-0.7	0.2	-1.0	-0.6	-0.2	-0.5	-1.0	-0.9	-0.4
Major Depression (MDD)	3.8	4.6	7.8	-2.3	0.2	-2.2	-2.2	-2.8	2.4	0.3	1.7	2.3	2.0	2.1	1.9	1.8	2.4	2.6	2.4	2.4	2.3
Reaction Time	0.6	1.2	2.8	-0.4	0.9	-1.7	-0.7	-1.4	0.4	0.8	1.3	0.9	1.6	0.4	1.4	1.2	0.8	1.4	1.1	1.1	0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.2	1.2	-0.0	-0.7	-0.2	0.5	-0.1	-0.4	-0.4	0.7	-1.1	-0.7	0.0	-0.2	-0.5	-0.3	-0.2	-0.0	-0.1	-0.4
Breast Cancer	0.2	0.5	1.3	-0.9	1.1	0.2	-1.0	-1.1	0.5	0.6	0.7	0.6	0.7	0.4	0.6	1.1	-0.2	0.5	0.3	0.3	0.3
Ovarian Cancer	0.2	0.2	0.8	0.1	-0.7	-0.3	-0.2	-0.2	0.3	-0.6	0.9	-0.9	-0.4	0.5	-0.6	0.1	-0.3	-0.4	-0.2	-0.6	-0.1
Prostate Cancer	0.2	0.2	0.9	-0.1	-0.4	-0.3	0.0	-0.4	-0.4	-0.8	0.3	0.6	0.9	0.4	-0.2	0.5	-0.2	0.7	-0.1	-0.6	0.4
Age at First Birth	1.1	1.6	3.9	0.8	-2.0	0.8	1.5	0.9	-0.3	-1.6	-1.4	-0.9	-1.8	-0.8	-1.5	-1.7	-0.5	-1.5	-1.0	-0.8	-1.3
Bipolar Disorder (2011)	1.8	1.7	3.0	-0.7	0.9	-1.2	-1.6	-1.4	1.2	0.3	1.7	0.6	1.4	1.6	1.5	1.3	1.1	1.7	1.5	1.5	1.4
Body Mass Index (BMI) (2010)	0.5	0.7	2.8	1.5	0.2	-1.1	0.6	0.7	-0.6	0.1	0.1	-1.7	-0.6	-0.2	-0.6	-0.3	-0.7	-0.9	-0.7	-1.0	-1.3
Coronary Artery Disease (CAD)	0.7	0.8	2.4	1.3	-1.1	0.9	1.1	1.3	-0.8	-1.5	0.1	-0.9	-0.5	0.2	-1.1	-0.5	-0.2	-0.5	-0.9	-1.0	0.3
Crohns Disease (2012)	0.2	0.2	1.1	0.5	-0.6	-1.0	0.6	0.5	-0.3	-1.1	0.0	0.4	-0.0	-0.1	-0.5	-0.2	-0.2	0.2	-0.6	-0.4	-0.0
Mean Putamen Volume	3.7	4.3	9.3	-0.0	-1.1	1.4	0.9	1.3	-1.9	-1.1	-2.0	-2.2	-2.8	-2.5	-2.1	-2.3	-3.0	-2.5	-2.4	-1.9	-3.0
Fasting Glucose	0.2	0.2	0.9	0.3	-0.2	-1.0	0.2	-0.2	-0.4	0.4	0.8	-0.2	0.8	0.1	0.1	0.6	0.0	-0.1	0.2	-0.7	0.7
HbA1C	0.5	0.5	2.2	1.5	1.1	1.1	1.1	0.8	-0.3	1.2	0.2	0.2	0.6	0.6	0.4	0.6	-0.1	0.5	-0.0	-0.1	0.2
HDL Cholesterol	0.1	0.2	0.9	-0.4	0.3	0.3	-0.4	0.6	-0.5	0.0	0.1	-0.3	-0.1	-0.3	-0.2	0.1	-0.9	-0.3	-0.4	-0.6	0.2
LDL Cholesterol	0.3	0.4	1.3	1.1	0.5	-0.8	0.5	0.8	-1.0	0.1	0.7	-0.8	0.6	0.2	-0.1	0.5	-0.7	-0.2	-0.2	-1.1	0.1
Lupus	2.8	4.3	14.4	1.1	-2.3	1.8	2.6	2.6	-1.5	-3.8	-1.1	-1.0	-1.8	-0.8	-3.0	-2.1	-1.2	-1.3	-2.5	-2.4	-1.0
Neuroticism (2016)	0.2	0.3	1.2	-1.0	0.3	-0.5	-0.7	-1.0	-0.1	-0.1	1.1	-0.1	0.3	-0.1	0.5	0.3	-0.2	0.7	0.4	0.7	0.1
Primary Biliary Cirrhosis	0.2	0.4	1.0	-0.4	-0.1	-0.4	-0.5	-0.1	0.4	0.1	1.0	0.3	0.8	0.9	0.4	0.9	0.5	0.7	0.6	0.2	0.9
Rheumatoid Arthritis	0.8	1.1	2.0	1.1	-0.4	1.2	0.9	0.6	-0.9	-1.3	-1.4	-0.7	-1.0	-1.1	-1.2	-1.4	-0.9	-1.1	-1.2	-0.9	-1.2
Schizophrenia (2014)	0.1	0.3	2.3	0.9	0.3	1.5	0.2	0.0	-0.0	0.3	0.4	-0.4	0.1	0.4	-0.4	0.4	-0.3	-0.1	-0.5	-0.7	-0.5
Triglycerides	0.2	0.3	0.8	-0.3	-0.4	-0.2	-0.3	-0.8	0.5	-0.8	0.8	0.1	0.5	0.9	0.3	0.4	0.8	0.8	0.5	0.7	0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.4	0.6	0.4	0.1	0.5	0.0	-0.1	-0.1	0.1	-0.0	0.2	-0.0	-0.1	0.2	0.0	-0.3	-0.1	-0.3	-0.1
Ulcerative Colitis	0.4	0.6	3.3	1.5	0.8	1.8	0.7	0.9	0.3	0.7	0.1	0.2	0.5	1.3	0.1	0.6	0.4	0.7	-0.2	-0.2	0.7
Blood Eosinophil Count	2.0	15.2	29.6	-3.6	2.2	-2.5	-3.6	-4.1	3.6	2.4	3.2	4.3	4.3	2.9	4.5	3.5	4.3	5.1	4.5	5.4	4.3
Blood Platelet Count	0.0	0.5	1.7	-0.4	-1.3	1.2	-0.6	-0.3	0.4	-0.9	1.3	-1.0	-0.3	0.5	-0.9	-0.4	-0.0	0.6	-0.6	0.4	0.2
Blood Red Count	0.3	3.3	12.2	-1.9	2.4	-0.4	-1.8	-1.3	2.2	1.7	0.3	1.7	0.6	1.0	2.5	0.8	2.2	1.6	2.3	3.5	1.1
Blood White Count	0.1	0.8	2.3	-0.2	0.5	-0.4	-0.7	-0.7	-0.2	0.4	-0.7	-1.2	-1.4	-1.2	0.1	-1.4	-1.1	-0.1	-0.4	1.1	-1.5
Heel T-Score	0.2	1.5	5.6	-1.7	-1.7	-1.4	-1.0	-0.8	0.6	-0.1	0.1	-2.1	-1.9	-0.5	-0.3	-1.4	-0.1	-1.1	0.3	0.6	-2.4
BMI	0.2	1.0	7.1	-0.5	0.0	-2.7	-0.5	0.5	0.1	-1.0	0.7	-1.6	-1.0	0.1	-0.5	0.0	-0.4	-1.3	-0.2	-0.9	-1.4
Height	0.3	5.2	15.0	0.1	-3.3	3.9	2.1	1.8	-0.9	-3.0	-2.6	-0.4	-2.6	-1.4	-3.0	-2.8	-0.9	-2.2	-2.2	-2.2	-1.3
Waist Hip Ratio (WHR)	0.3	1.3	3.2	-0.5	0.7	0.5	-1.0	-0.9	1.8	1.0	0.5	1.6	1.0	1.6	0.9	1.2	1.4	1.4	0.9	1.1	1.0
Systolic Blood Pressure	0.2	1.1	4.6	1.6	0.6	-1.7	0.1	1.3	-1.0	0.4	0.0	-2.1	-0.8	-0.5	-0.1	-0.6	-1.6	-0.6	-0.6	-0.4	-1.5
Smoking Status	0.1	0.2	0.7	-0.4	0.2	0.1	-0.7	0.3	0.8	-0.2	0.6	-0.2	0.1	0.7	0.2	0.3	0.5	0.6	0.3	0.8	0.6
Allergy or Eczema	2.2	5.8	9.6	-2.7	0.9	-1.7	-2.8	-2.4	2.2	1.5	2.6	2.0	2.4	2.1	2.7	2.2	2.5	2.8	3.0	3.1	2.5
Cardiovascular Disease	0.1	0.4	2.2	-0.4	0.4	-1.5	-0.7	0.0	0.8	0.0	1.0	-0.1	0.3	0.8	0.2	0.8	0.4	-0.0	0.5	-0.0	0.0
Hypothyroidism (self reported)	0.9	2.1	5.2	-1.4	0.9	1.3	-0.9	-1.9	2.2	0.4	-0.1	2.3	1.2	1.6	1.2	1.2	2.3	1.1	1.6	1.3	1.3
Respiratory disease	0.2	0.4	1.4	0.1	-0.7	-0.0	0.5	0.3	-0.1	-0.8	-0.7	-0.6	-1.0	-1.0	-0.4	-1.2	-0.2	-0.6	-0.3	0.3	-0.7
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.7	1.1	-0.1	0.6	1.1	0.5	-0.3	-0.4	-0.8	-0.6	-1.0	-0.1	-1.3	-0.7	-0.7	-1.0	-1.2	-1.3	-0.8
Lung FEV1/FVC ratio	1.1	5.6	19.4	1.7	4.4	-0.8	-0.3	0.3	0.8	3.7	1.3	1.9	3.4	2.6	3.0	3.5	1.6	2.4	1.9	1.0	2.3
Lung FVC	0.3	1.3	8.8	-0.1	-1.2	3.0	1.2	0.8	0.4	-1.6	-1.4	0.3	-1.3	-0.1	-1.1	-1.4	0.5	-0.8	-0.6	-0.3	-0.2
Neuroticism	0.3	0.7	2.7	-0.6	-0.8	-1.0	-0.5	-1.0	0.2	0.5	1.1	1.0	1.2	0.5	0.3	1.1	0.4	0.5	0.7	-0.1	1.6
Chronotype (morning person)	1.7	4.0	8.3	1.3	-0.6	1.7	2.4	2.9	-2.2	-2.3	-2.4	-1.3	-2.0	-2.1	-1.9	-2.0	-1.9	-2.2	-2.2	-1.9	-1.4
Hair Pigment	0.0	0.4	1.3	0.5	0.9	0.4	-0.3	0.3	0.1	0.9	-0.2	1.1	1.1	0.3	0.8	0.9	-0.2	0.5	0.3	-0.1	0.3
Tanning	0.5	5.9	11.2	1.5	-2.1	2.4	2.2	2.0	-1.3	-2.8	-1.0	-3.2	-3.3	-0.9	-3.4	-2.6	-1.9	-2.8	-2.8	-2.7	-2.6
Hand grip strength (left)	0.5	1.3	3.1	0.9	-0.6	1.0	1.2	1.4	-0.8	-1.0	-0.6	-1.6	-1.7	-0.7	-1.2	-1.1	-0.9	-1.8	-1.0	-1.2	-0.9
Number of treatments/medications taken	0.1	0.2	0.8	0.5	0.2	-0.7	0.7	-0.1	-0.1	0.8	-0.8	0.5	0.0	-0.9	0.0	0.1	0.4	-0.6	-0.2	-0.3	-0.3
Average weekly spirits intake	0.5	0.6	1.7	0.1	-1.2	-0.1	-0.3	0.6	-0.4	-1.0	0.2	-1.3	-0.8	-0.2	-0.7	-0.9	-1.1	-0.0	-0.8	-0.2	-1.2
Sensitivity / hurt feelings	0.1	0.2	0.8	-0.5	-0.9	0.3	-0.1	-0.3	0.1	-0.8	-0.3	-0.1	-0.5	-0.2	-0.7	-0.4	-0.5	-0.5	-0.4	-0.6	-0.3
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.4	-0.3	-0.7	-0.5	0.4	-0.0	-0.8	0.2	-0.3	-0.4	-0.3	-1.2	-0.5	-0.4	-0.7	-1.0	-0.4	-0.9	-0.7
Hearing difficulty/problems: Yes	0.7	1.0	2.6	1.6	1.3	1.3	1.3	0.7	-1.4	0.9	-1.6	1.0	0.6	-1.5	0.3	-0.6	-0.4	0.2	-0.5	-0.1	0.2
Relative age of first facial hair	0.5	0.9	3.0	-1.7	0.4	-1.1	-1.7	-0.9	1.2	0.5	1.3	0.2	0.2	0.7	1.0	0.7	0.8	0.4	1.2	1.2	0.2
Other serious medical condition/disability diagnosed by doctor	4.2	5.4	10.9	-0.7	2.9	-0.6	-1.4	-1.9	2.1	2.6	0.4	3.3	3.1	1.8	3.1	2.5	2.6	2.6	2.6	2.5	2.2
Ever used hormone-replacement therapy (HRT)	5.4	6.8	33.5	1.2	4.9	-1.4	-0.5	-0.8	0.3	5.8	1.0	2.4	3.6	1.4	3.4	3.7	1.3	2.0	2.0	1.0	2.0
Ever had hysterectomy (womb removed)	1.6	1.8	9.3	0.7	2.3	-0.9	-1.0	-0.8	1.0	3.0	0.9	0.4	1.3	1.3	1.6	1.5	0.8	1.0	1.3	1.0	0.8
Systolic blood pressure, automated reading	1.3	3.8	8.7	2.8	0.9	0.5	2.1	3.0	-2.2	-0.6	-2.1	-2.1	-1.8	-1.7	-1.4	-1.8	-2.2	-1.9	-2.0	-1.9	-2.1
Eye problems/disorders: Diabetes related eye disease	1.1	1.3	3.9	1.6	0.5	1.9	1.6	1.2	-1.0	0.1	-2.0	0.8	-0.2	-0.9	-1.1	-0.8	-0.5	-0.5	-1.4	-1.0	-0.3
Angina	0.1	0.2	1.1	0.1	0.2	-0.4	-0.0	-1.0	0.5	0.2	-0.6	0.6	0.1	0.1	0.3	-0.1	0.3	0.3	0.3	0.5	-0.4
Medication for hormone replacement therapy	2.4	2.7	8.8	-0.7	1.7	-0.7	-1.4	-1.5	1.1	3.0	1.4	1.4	2.1	1.4	2.3	2.3	1.0	1.6	1.8	1.3	1.2
Vitamin and mineral supplements	0.4	0.5	2.4	0.6	0.3	-0.9	-0.0	-0.3	-0.8	0.7	-0.4	-1.1	-0.7	-0.7	-0.2	-0.5	-1.1	-0.7	-0.5	-0.4	-1.6
Supplements: Zinc	0.6	0.7	2.7	1.3	1.6	-1.4	0.6	0.1	-0.3	1.2	0.3	0.6	1.3	-0.0	0.2	1.1	0.2	0.3	-0.2	-0.8	0.4
Medication: Co-codamol	0.4	0.5	1.6	1.0	0.5	-1.0	0.5	0.3	-1.2	0.7	-0.8	-0.5	0.0	-1.3	0.6	-0.2	-0.9	-0.5	-0.2	0.0	-0.6
Medication: Metformin	1.3	1.8	5.4	1.1	-0.4	-0.4	1.1	1.0	-1.4	-0.7	-0.3	-2.3	-1.6	-1.2	-1.4	-1.3	-1.5	-1.7	-1.5	-1.4	-1.8
Diabetes (father)	0.5	0.6	3.4	0.4	1.3	-1.2	-0.2	0.4	-0.2	0.5	1.8	-0.9	0.8	0.8	0.4	1.2	-0.1	0.4	0.2	-0.3	0.2
Diabetes (mother)	0.4	0.5	1.5	-0.3	0.3	0.7	-1.0	-0.9	1.2	0.7	0.8	0.4	0.3	1.2	0.5	0.8	0.9	0.6	0.6	0.7	0.5
Severe depression (siblings)	2.7	3.0	7.2	-1.7	0.6	0.7	-1.6	-2.1	2.2	0.1	1.1	2.1	1.3	1.6	1.9	1.0	2.4	2.2	2.1	2.7	1.7
Pack years adult smoking proportion	1.2	1.8	3.7	1.7	-1.5	-0.4	1.8	1.2	-1.9	-1.2	-0.8	-1.5	-0.9	-1.5	-1.3	-1.6	-1.7	-0.9	-1.3	-1.3	-1.0
Impedance of leg (right)	0.3	1.6	4.3	0.6	1.1	0.8	-0.5	-1.1	0.7	1.1	0.4	2.1	1.9	0.8	1.3	1.2	0.9	2.1	1.0	1.4	1.6
Leg fat-free mass (left)	0.3	1.8	4.8	-0.1	-1.4	-0.0	1.0	1.6	-0.6	-1.4	-1.2	-1.5	-2.1	-0.9	-1.7	-1.4	-0.6	-2.2	-1.3	-1.5	-1.5
Trunk fat percentage	0.1	0.5	4.2	-1.0	0.4	-2.1	-0.9	-0.6	0.6	0.0	0.3	0.2	0.2	0.0	0.5	0.5	0.6	-0.2	0.6	0.3	-0.0
Hand grip strength (right)	0.1	0.1	0.3	0.5	-0.4	-0.1	0.4	0.5	-0.4	-0.6	0.1	-0.6	-0.2	0.1	-0.1	0.1	-0.4	-0.5	0.0	-0.5	0.4
Townsend deprivation index at recruitment	0.5	0.7	4.8	0.5	-0.9	2.2	0.8	1.1	-0.1	-0.5	-1.2	-0.1	-0.9	-0.3	-0.6	-1.2	-0.2	-0.4	-0.5	-0.0	-0.3
Current tobacco smoking	0.1	0.2	1.0	0.4	-0.3	0.1	0.3	0.6	-0.6	-0.8	0.3	-1.0	-0.3	-0.4	-0.1	-0.6	-0.7	0.3	-0.4	0.4	0.2
Average weekly fortified wine intake	1.2	1.4	3.9	-1.0	0.0	0.1	-1.1	-1.1	1.5	-0.7	1.3	0.6	0.7	2.0	0.8	0.8	1.3	1.6	1.2	1.5	1.8
Maternal smoking around birth	0.2	0.3	1.0	0.5	0.9	-0.3	-0.1	0.5	-0.6	0.2	-0.2	-1.0	-0.3	-0.7	-0.0	-0.6	-0.9	-0.4	-0.2	-0.0	-0.7
Fed-up feelings	0.3	0.6	1.9	-1.4	0.3	-0.9	-1.2	-1.1	-0.3	-0.1	1.2	0.3	0.9	-0.3	0.3	1.2	-0.6	-0.1	0.4	-0.5	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	2.9	6.5	-1.1	1.7	-1.8	-1.7	-1.8	1.0	2.1	1.7	1.0	2.0	1.0	2.5	1.9	1.1	1.6	2.3	1.9	1.0
Relative age voice broke	0.1	0.2	0.5	-0.7	-0.4	0.0	-0.3	0.7	0.3	-0.4	0.5	-0.6	-0.6	0.2	-0.3	-0.1	0.2	-0.5	0.0	-0.0	-0.1
Taking other prescription medications	0.3	0.5	1.6	-0.5	0.3	-0.6	-0.5	-1.1	0.5	0.2	0.0	1.3	0.9	-0.2	0.8	0.8	1.0	0.3	0.7	0.7	0.4
Age when periods started (menarche)	0.1	0.3	1.1	-0.6	-0.3	0.3	0.1	-1.1	0.6	-0.4	-0.2	0.7	0.2	0.4	0.5	-0.1	1.0	0.7	0.7	0.9	0.3
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	4.2	1.3	1.4	-1.0	0.8	0.9	-0.2	2.0	0.1	-1.0	-0.2	0.2	0.2	0.4	-0.1	-1.0	0.0	-0.8	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	2.8	-1.7	0.4	-1.5	-1.5	-1.3	1.4	1.1	0.5	0.1	0.1	0.6	1.0	0.3	1.0	0.5	1.1	1.4	-0.4
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	2.1	-0.4	-0.1	1.4	-0.0	-0.6	0.3	0.5	-0.8	0.8	-0.0	0.2	0.3	-0.2	0.5	0.0	0.5	0.5	0.5
Qualifications: CSEs or equivalent	4.1	5.5	10.5	2.5	-0.1	1.0	2.5	2.5	-2.3	-0.4	-2.1	-2.9	-2.7	-2.2	-2.2	-2.1	-2.4	-3.1	-2.6	-2.6	-3.2
Serious illness, injury or assault to yourself	0.9	1.1	2.7	-0.3	0.9	-1.0	-0.7	-0.9	0.6	1.1	1.0	1.0	1.5	0.8	1.1	1.3	1.2	1.3	0.9	0.8	1.6
High blood pressure	0.1	0.4	4.6	-0.4	-0.5	-2.1	-0.5	-0.2	-0.1	-0.4	0.3	-0.4	-0.2	-0.3	-0.1	0.3	-0.5	-0.6	-0.1	-0.5	-0.4
Hayfever, allergic rhinitis or eczema	0.6	1.3	2.4	-1.4	0.5	0.0	-1.2	-1.3	0.8	0.8	1.0	1.4	1.3	0.7	1.3	1.0	1.3	1.4	1.5	1.6	1.3
Multivitamins +/- minerals	0.9	1.1	4.3	-1.1	-0.3	0.3	-0.2	-0.1	1.6	-0.2	-0.0	2.1	0.9	1.0	0.6	0.6	2.0	0.9	1.2	1.1	1.6
Stomach or abdominal pain in last month	0.3	0.3	1.6	0.7	1.3	0.6	-0.0	-0.5	0.1	1.2	0.2	0.0	0.4	0.0	0.8	0.3	-0.1	0.4	0.3	0.6	0.1
Supplements: Glucosamine	0.9	1.2	3.0	-0.5	0.6	0.3	-0.7	-0.1	1.2	1.3	0.6	1.3	1.2	1.2	1.1	1.3	1.6	1.2	1.0	1.2	1.7
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.4	1.6	1.0	0.4	0.7	0.4	0.3	1.5	-0.5	0.8	0.9	0.5	0.7	0.9	1.1	-0.0	0.6	-0.2	0.6
Medication: Atenolol	0.3	0.3	1.9	-0.4	-1.2	-0.8	-0.2	-0.7	-0.2	-1.4	0.5	-0.4	-0.0	-0.3	-0.5	0.0	-0.5	-0.3	-0.3	-0.6	-0.3
Medication: Levothyroxine sodium	0.2	0.4	1.4	-1.0	-0.0	0.4	0.0	-1.1	0.5	-0.2	-0.9	0.8	0.1	-0.2	0.5	-0.3	1.2	-0.0	0.8	0.7	0.1
Sitting height	0.8	5.9	11.2	0.8	-2.9	3.4	2.2	1.9	-1.2	-3.1	-2.6	-1.0	-2.9	-1.6	-3.2	-2.6	-1.5	-2.8	-2.6	-2.8	-2.2
Chronic bronchitis/emphysema (father)	0.2	0.2	1.2	-0.2	0.2	-1.1	-0.1	-0.4	-0.5	0.2	-0.2	0.4	0.4	-0.4	0.6	-0.1	-0.6	0.5	0.4	0.5	0.8
High blood pressure (mother)	0.5	0.8	1.7	0.9	0.4	-0.6	1.1	1.3	-1.1	-0.5	-0.4	-0.7	-0.4	-1.2	-0.8	-0.3	-0.8	-1.0	-1.1	-1.2	-1.1
Body mass index (BMI)	0.1	0.5	3.3	-0.4	0.5	-1.8	-0.2	0.7	-0.0	-0.0	0.2	-1.5	-0.8	-0.2	-0.2	-0.1	-0.2	-1.2	-0.1	-0.5	-0.9
Impedance of leg (left)	0.3	1.5	4.5	0.5	0.9	0.6	-0.6	-1.2	0.6	0.8	0.6	2.1	1.9	0.7	1.3	1.3	0.8	2.0	1.0	1.3	1.7
Leg predicted mass (left)	0.4	1.9	4.9	-0.0	-1.3	0.1	1.1	1.6	-0.6	-1.4	-1.3	-1.5	-2.1	-1.0	-1.7	-1.5	-0.7	-2.2	-1.3	-1.5	-1.5
Trunk fat mass	0.1	0.3	2.0	-0.6	0.2	-1.4	-0.2	0.1	0.2	-0.4	-0.4	-0.2	-0.5	-0.4	-0.2	-0.1	0.3	-0.9	-0.0	-0.3	-0.6
Waist circumference	0.1	0.2	0.7	0.0	0.8	-0.7	0.2	0.7	0.2	0.2	-0.6	-0.4	-0.6	-0.0	-0.2	-0.1	0.3	-0.8	-0.3	-0.3	-0.7
Number of incorrect matches in round	1.1	1.8	5.5	1.5	0.0	2.4	1.8	1.4	-1.2	-1.2	-1.9	0.2	-0.8	-1.5	-1.2	-1.1	-1.1	-1.0	-1.6	-1.2	-0.7
Past tobacco smoking	0.2	0.4	1.3	-0.2	-0.5	-0.3	0.4	-0.2	-0.8	-0.5	0.3	-1.1	-0.7	-0.5	-0.5	-0.7	-0.8	-0.6	-0.3	-0.7	-0.9
Alcohol usually taken with meals	2.0	3.2	9.1	-0.7	1.7	-1.8	-0.9	-1.0	0.6	1.7	1.9	1.8	2.6	1.3	2.0	2.2	1.4	2.3	1.8	1.4	3.0
Nervous feelings	1.6	2.9	7.4	1.3	-1.4	1.7	1.3	1.1	-1.9	-1.2	-1.6	-0.8	-1.1	-2.0	-2.1	-1.3	-2.3	-2.0	-2.1	-2.7	-1.8
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.2	5.2	-2.2	0.6	-0.5	-2.2	-2.2	1.4	0.4	2.1	2.0	2.3	1.2	1.8	2.2	1.4	1.9	2.0	1.5	2.2
Hearing difficulty/problems with background noise	0.4	0.6	2.5	1.6	0.6	1.0	1.1	0.0	-0.8	1.1	-1.2	1.1	0.6	-0.7	0.3	-0.1	-0.1	0.3	-0.2	-0.1	0.4
Hair/balding pattern: Pattern 2	1.0	1.3	3.2	-1.2	0.7	-1.2	-1.2	-0.6	0.8	0.6	1.8	0.1	1.2	1.4	1.1	1.2	0.8	1.5	1.1	1.3	1.5
Had menopause	5.2	6.4	14.1	-0.2	3.7	-1.9	-1.4	-1.3	1.2	3.8	2.0	2.2	3.7	2.1	3.3	3.4	1.9	2.8	2.5	1.9	2.9
Had other major operations	0.3	0.4	1.1	0.2	1.0	-0.6	-0.3	-0.3	0.5	0.9	0.1	0.5	0.7	0.4	0.7	0.7	0.7	0.4	0.6	0.5	0.8
Forced vital capacity (FVC)	0.7	2.6	5.6	0.4	-2.4	2.3	1.6	2.2	-0.4	-2.4	-1.5	-0.8	-2.2	-0.7	-2.1	-2.0	-0.3	-1.7	-1.4	-1.2	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	2.3	-1.5	-0.2	0.3	-1.1	-0.9	1.3	0.4	-0.3	-0.1	-0.9	0.2	0.1	-0.4	0.6	-0.4	0.4	0.7	-0.9
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	2.1	-1.4	-0.9	-0.2	-0.5	-1.1	0.5	-0.7	0.7	0.4	0.4	0.4	0.4	-0.1	0.6	0.7	0.9	0.8	0.8
Qualifications: None of the above	0.5	1.1	10.2	0.4	1.4	-3.2	-0.2	-0.4	-0.1	1.5	0.3	-0.5	0.7	-0.1	1.4	0.6	0.2	0.3	0.9	0.9	0.1
Financial difficulties in last 2 years	0.2	0.3	1.8	0.8	1.4	0.2	0.5	1.0	-0.4	0.8	0.3	-0.7	-0.2	-0.0	0.5	0.0	0.0	-0.2	0.1	0.2	0.1
Mouth/teeth dental problems	1.2	1.8	5.1	-0.8	-2.3	2.0	0.4	0.9	-0.2	-1.5	-0.9	-0.6	-1.9	-0.6	-1.9	-1.9	-0.7	-1.0	-1.3	-0.8	-1.7
Heart attack	0.3	0.3	2.1	1.5	1.0	0.4	0.9	0.4	-0.5	1.2	-0.3	0.0	0.1	-0.0	-0.0	0.2	-0.1	0.0	-0.5	-0.4	0.0
Allergy	0.0	0.1	0.2	-0.3	0.2	-0.0	-0.2	-0.2	0.4	-0.2	0.1	0.4	0.2	0.4	0.1	0.4	0.3	0.1	0.1	-0.1	0.2
Pain all over the body in last month	0.7	0.7	1.8	-0.3	1.1	-0.8	-0.4	-0.6	0.7	1.0	0.2	1.4	1.0	0.4	0.8	0.8	1.3	0.7	0.7	0.7	1.3
Diabetes (self-reported)	0.5	0.7	2.6	1.5	-0.0	-0.7	1.0	1.0	-0.8	-0.5	0.0	-0.9	-0.3	-0.1	-1.1	-0.2	-0.8	-0.8	-1.0	-1.6	-0.6
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.8	-1.1	0.3	-0.1	-1.0	-1.5	0.6	0.2	-0.1	1.9	1.2	0.4	1.3	0.7	0.6	1.3	1.4	1.2	1.4
Medication: Ramipril	0.2	0.3	1.1	0.2	0.9	-0.4	0.2	0.2	-0.4	-0.1	0.3	-1.1	-0.7	-0.3	0.0	-0.1	-1.0	-0.5	-0.4	-0.2	-0.7
Medication: Simvastatin	0.2	0.4	1.6	-0.3	1.3	-0.5	-0.4	-1.1	0.7	0.6	-0.0	0.0	0.1	0.3	0.6	0.4	0.7	0.0	0.4	0.6	-0.9
Fluid intelligence score	0.2	0.4	1.6	-0.4	-1.3	-0.6	-0.2	-0.5	-0.3	-0.9	1.1	-1.2	-0.4	0.0	-0.1	-0.2	-0.5	-0.1	0.1	-0.0	-0.6
Illnesses of siblings	0.4	0.5	3.3	0.1	-1.0	0.4	0.1	0.9	-0.7	-1.8	-0.5	-0.3	-0.5	-0.5	-0.5	-0.5	-1.0	-0.4	-0.6	-0.4	-0.1
Neuroticism score	0.2	0.5	1.8	0.2	-1.0	0.2	0.7	0.0	-1.1	-0.7	-0.1	0.1	0.2	-0.8	-0.9	-0.1	-1.0	-0.5	-0.7	-1.3	0.2
Weight	0.2	1.1	3.8	-0.0	-0.4	-0.5	0.7	1.3	-0.4	-0.8	-1.1	-1.3	-1.6	-0.8	-1.1	-1.0	-0.5	-1.9	-0.9	-1.2	-1.3
Impedance of arm (right)	0.2	1.0	3.7	-0.2	0.6	0.7	-0.5	-1.6	0.7	0.9	-0.0	1.9	1.3	0.4	1.0	0.8	0.8	1.4	0.8	1.1	0.9
Arm fat percentage (right)	0.1	0.3	1.4	-0.6	0.6	-1.2	-0.2	0.1	0.2	-0.1	-0.3	-0.6	-0.7	-0.3	-0.1	-0.1	-0.0	-0.9	-0.1	-0.2	-0.8
Trunk fat-free mass	0.4	2.5	4.9	1.0	-1.0	1.3	1.9	2.2	-1.1	-1.1	-1.9	-1.4	-2.1	-1.1	-1.8	-1.8	-0.9	-2.2	-1.6	-1.8	-1.4
Hip circumference	0.1	0.5	3.3	-0.9	-0.3	-1.8	-0.2	0.3	0.2	-0.5	-0.1	-1.0	-0.9	-0.2	-0.3	-0.4	0.2	-1.0	-0.1	-0.2	-0.7
Time employed in main current job	0.6	0.7	3.5	-0.4	1.3	-1.9	-0.9	-0.7	0.8	0.5	0.7	-0.9	-0.5	0.2	0.7	0.3	0.5	-0.4	0.6	0.7	-0.9
Alcohol intake versus 10 years previously	2.8	4.2	9.5	3.1	0.7	-1.1	2.3	2.6	-2.7	0.3	-2.1	-2.2	-1.4	-2.5	-1.2	-1.7	-2.3	-2.1	-2.0	-1.9	-2.1
Father’s age at death	1.3	1.7	4.8	-0.1	2.0	-0.5	-0.7	-0.5	0.6	2.2	1.7	0.8	1.7	1.3	1.5	1.7	0.9	1.5	1.2	1.0	1.4
Worrier / anxious feelings	0.4	0.7	2.2	0.4	1.1	0.2	-0.3	-0.4	-0.1	0.9	0.5	1.3	1.5	0.5	0.7	1.5	-0.2	0.8	0.3	-0.2	1.3
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.8	8.0	-0.2	2.6	-2.0	-1.2	-0.8	1.4	1.6	1.6	2.0	2.8	2.0	2.4	2.7	1.8	2.3	2.0	1.7	2.1
Falls in the last year	1.1	1.5	2.8	1.5	0.7	1.1	1.7	1.0	-1.5	0.1	-1.7	-0.7	-0.9	-1.6	-0.7	-1.1	-1.4	-1.4	-1.2	-1.2	-1.1
Hair/balding pattern: Pattern 3	0.4	0.6	3.0	0.3	-1.7	0.8	0.1	-0.0	-0.7	-1.2	-0.7	-0.4	-0.7	-1.1	-0.8	-1.0	-0.9	-0.6	-0.7	-0.5	-0.6
Number of live births	2.0	2.9	8.6	-0.5	2.9	-0.9	-1.5	-1.5	1.0	2.7	1.4	0.7	1.9	1.5	2.5	2.3	0.9	1.7	1.7	1.4	0.9
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	3.8	0.6	-1.2	1.9	1.2	2.0	-0.0	-1.2	-0.9	0.0	-1.0	0.2	-1.1	-0.8	0.1	-0.7	-0.7	-0.7	0.4
Pulse rate	0.2	0.4	1.2	0.0	1.1	-0.3	-0.8	-0.7	0.8	0.8	0.8	-0.3	0.2	1.0	0.3	0.6	-0.0	0.5	0.2	0.5	-0.3
Happiness	0.8	0.9	2.1	-1.0	1.4	0.1	-0.9	-1.2	0.4	1.3	1.0	0.7	1.4	0.3	1.2	1.4	0.6	0.6	1.0	0.6	0.6
Noisy workplace	0.4	0.5	2.2	-0.8	0.4	1.5	-0.7	-1.0	0.7	1.2	0.1	0.5	0.1	0.6	0.2	0.5	0.3	0.3	0.2	0.4	0.6
Qualifications: A levels/AS levels or equivalent	0.6	1.3	7.4	-1.1	-1.5	2.7	-0.5	-1.0	1.2	-1.7	0.7	1.4	0.3	1.4	-0.3	0.4	1.0	1.1	0.2	0.4	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	5.0	0.0	0.4	-2.2	-0.3	-0.6	-0.2	0.7	0.2	0.3	0.7	-0.0	0.8	0.5	0.1	0.7	0.4	0.7	0.2
Mouth/teeth dental problems: Dentures	0.4	0.8	3.2	1.1	1.1	0.4	0.5	0.0	-0.8	0.9	-1.8	0.1	-0.4	-1.2	-0.1	-0.3	-1.1	-1.0	-0.7	-0.9	-0.9
Asthma	1.0	2.0	4.5	0.9	-1.1	0.6	1.0	0.9	-1.1	-0.6	-1.4	-1.7	-1.9	-1.9	-1.3	-1.9	-1.6	-1.7	-1.3	-0.9	-2.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	3.6	0.6	-1.2	1.0	1.0	1.7	-0.8	-1.9	-0.4	-0.4	-0.7	-0.6	-1.0	-0.6	-0.5	-0.6	-1.2	-0.9	0.0
Medication: Cholesterol lowering	0.5	0.9	3.0	0.9	0.6	-1.7	0.3	0.0	-0.7	0.7	-0.0	-1.7	-0.9	-0.8	-0.4	-0.5	-0.7	-1.1	-0.5	-0.6	-1.7
Depression (self-reported)	0.4	0.4	1.5	-0.6	-0.8	-1.2	-0.4	-0.9	0.4	0.3	1.0	0.2	0.5	0.5	0.4	0.6	0.7	0.4	0.7	0.4	0.9
Medication: Lansoprazole	1.5	1.7	5.4	-0.3	1.6	0.0	-0.7	-0.3	0.7	0.9	0.6	2.0	1.7	0.8	1.7	1.5	1.3	1.7	1.2	1.3	2.3
Prospective memory result	0.4	0.5	1.4	0.2	-0.3	0.2	0.6	0.7	-0.9	-0.8	-0.7	0.0	-0.4	-1.2	-0.6	-0.5	-0.8	-0.9	-0.6	-1.0	-0.6
Lung cancer (father)	0.8	1.0	1.9	-0.3	1.2	-0.6	-1.0	-1.2	1.1	0.9	0.1	1.1	0.8	1.0	1.4	1.0	0.8	0.9	1.3	1.2	0.9
Illnesses of mother	1.0	1.2	3.5	0.5	-1.9	1.0	1.1	0.8	-0.6	-1.4	-1.3	-1.1	-1.6	-0.6	-1.2	-1.8	-0.5	-1.0	-0.8	-0.5	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	8.5	0.4	-1.7	2.9	1.3	1.9	-0.1	-2.2	-1.2	-0.3	-1.7	-0.0	-1.7	-1.4	-0.2	-1.0	-1.3	-1.0	-0.2
Pulse wave Arterial Stiffness index	0.8	0.9	4.0	2.0	-0.2	-0.5	1.5	1.4	-1.1	0.6	-0.8	-1.1	-0.3	-0.6	-0.7	-0.7	-0.8	-0.6	-0.9	-0.8	-0.5
Impedance of arm (left)	0.4	1.9	4.7	-0.7	0.5	-0.7	-1.1	-2.2	1.2	1.1	0.7	2.0	1.8	0.7	1.6	1.4	1.4	1.8	1.4	1.7	1.4
Arm fat mass (right)	0.1	0.3	1.9	-0.6	0.4	-1.4	-0.1	0.5	0.1	-0.1	-0.3	-0.8	-0.8	-0.2	-0.2	-0.2	-0.0	-1.0	-0.2	-0.4	-0.8
Trunk predicted mass	0.4	2.3	4.5	1.0	-0.9	1.3	1.8	2.1	-1.0	-1.0	-1.8	-1.3	-2.0	-1.1	-1.7	-1.7	-0.9	-2.1	-1.6	-1.8	-1.3
Standing height	0.3	3.3	6.8	1.1	-2.0	2.6	2.2	1.8	-1.0	-1.8	-2.6	0.1	-1.8	-1.5	-2.3	-1.9	-0.8	-1.9	-2.0	-2.0	-0.9
Length of working week for main job	0.2	0.2	0.6	0.6	0.2	-0.4	0.5	0.2	-0.6	-0.1	-0.7	-0.0	-0.1	-0.8	-0.2	-0.3	-0.6	-0.7	-0.2	-0.6	-0.7
Exposure to tobacco smoke at home	1.4	1.5	4.3	1.9	-1.6	1.5	1.9	2.1	-0.3	-1.9	-0.9	-0.2	-0.8	0.2	-1.4	-1.2	0.4	-0.5	-0.9	-0.9	-0.1
Breastfed as a baby	1.6	2.0	4.1	0.6	-1.3	0.7	1.4	1.7	-0.6	-1.6	-0.7	-1.8	-2.0	-0.5	-2.0	-1.6	-0.8	-1.7	-1.6	-1.5	-1.7
Tense / ‘highly strung’	0.8	1.3	4.0	-0.3	0.3	-0.0	-0.5	-0.5	0.7	0.3	1.3	1.4	1.7	1.4	1.0	1.4	1.0	1.6	1.2	0.9	2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.2	-1.8	-0.9	-0.1	-1.1	-1.2	1.0	-0.2	1.1	1.1	0.9	0.8	0.5	0.8	1.0	1.2	0.9	1.0	1.7
Hair/balding pattern: Pattern 4	0.1	0.1	1.0	-0.1	-0.5	-1.0	0.1	0.1	-0.1	-0.1	0.3	-0.5	-0.3	-0.4	0.0	-0.3	-0.0	-0.6	0.3	-0.2	-0.4
Birth weight of first child	0.2	0.4	2.0	-0.9	-0.6	0.3	-0.1	-0.1	0.8	-0.2	-0.4	1.4	0.4	0.4	-0.3	-0.1	1.4	0.4	0.2	0.3	0.6
Peak expiratory flow (PEF)	0.2	0.4	1.7	0.2	-0.5	0.5	0.3	1.1	0.6	0.1	0.0	0.5	0.1	1.0	0.1	0.2	0.8	0.5	0.3	0.5	1.3
Pulse wave reflection index	2.4	3.0	4.2	1.5	-1.7	-0.5	1.9	1.5	-1.9	-1.1	-1.9	-1.6	-1.6	-2.0	-1.8	-2.1	-1.7	-2.0	-1.7	-1.9	-1.9
Ever highly irritable/argumentative for 2 days	0.2	0.2	1.1	-1.0	-0.3	-0.8	-0.7	-1.1	0.5	0.4	0.0	0.4	0.0	0.1	0.0	0.0	0.1	0.1	0.3	0.2	0.2
Loud music exposure frequency	0.8	0.8	7.8	0.6	0.4	-2.8	0.1	-0.0	-0.9	1.6	0.4	-0.2	0.9	-0.5	0.9	0.6	-0.4	0.0	0.6	-0.1	0.4
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	14.1	-0.0	-0.9	3.8	0.6	0.2	-0.1	-1.7	-0.5	0.6	-0.6	0.2	-1.1	-0.6	-0.6	-0.1	-0.9	-0.7	-0.2
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	5.7	1.3	1.2	-2.4	0.5	-0.2	-0.5	-0.3	1.2	0.0	1.6	0.5	1.1	1.2	0.1	1.1	0.7	0.2	1.1
Blood clot in the leg (DVT)	1.7	2.2	5.6	1.2	-1.9	0.5	0.9	1.8	-0.9	-0.8	-0.3	-2.4	-2.0	-0.2	-1.9	-1.3	-1.4	-1.8	-1.6	-1.8	-1.4
Medication: Paracetamol	0.3	0.5	2.8	0.7	0.9	-0.8	0.1	-0.4	-0.3	1.7	-1.2	0.6	0.4	-0.8	0.1	0.3	-0.4	-0.5	-0.3	-0.7	-0.7
Headache pain in last month	0.5	0.8	3.5	-0.2	0.1	0.5	0.1	-0.5	1.0	-0.0	0.5	1.9	1.3	1.3	0.3	1.3	1.3	1.0	0.6	0.1	1.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	5.3	-1.3	-1.0	0.4	-0.7	-0.2	1.0	-0.6	1.2	1.3	1.4	1.4	0.7	1.0	1.4	1.4	1.2	0.9	2.3
Glaucoma (self-reported)	0.6	0.7	2.2	0.4	-0.4	-0.3	0.8	0.3	-0.8	0.0	-0.9	-0.8	-0.9	-1.5	-0.6	-1.1	-0.8	-1.1	-0.8	-0.4	-1.1
Gout (self-reported)	0.3	0.4	3.4	0.2	0.4	-1.9	0.3	-0.2	-0.3	1.0	0.8	-0.6	0.5	-0.4	0.6	0.4	0.4	-0.1	0.6	0.3	0.4
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	5.3	-1.5	1.0	1.2	-1.1	-1.9	2.0	0.7	-0.1	2.2	1.2	1.4	1.4	1.2	2.3	1.0	1.8	1.4	1.1
Medication: Amlodipine	0.8	1.1	3.1	0.7	-0.0	0.7	0.7	0.1	-1.0	-0.9	-1.5	-0.7	-1.1	-1.3	-0.8	-1.1	-1.4	-1.2	-1.1	-1.1	-1.8
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.7	0.1	0.1	0.3	0.6	0.1	0.0	-0.3	-0.6	-0.7	-1.3	-0.6	-0.2	-1.3	-0.1	-0.4	-0.3	0.7	-0.9
Birth weight	0.7	1.4	4.3	1.3	-1.5	0.9	1.9	2.1	-1.2	-1.8	-1.4	0.4	-0.4	-0.9	-1.2	-1.0	-0.4	-0.6	-1.1	-1.1	0.3
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.9	0.1	-0.6	0.3	0.4	0.1	-0.7	0.6	-1.0	-0.5	-0.7	-1.3	-0.5	-0.8	-1.2	-1.2	-0.5	-1.0	-1.7
High blood pressure (siblings)	0.4	0.6	2.7	-0.7	0.9	-1.0	-0.4	-1.4	0.7	1.6	0.2	0.2	0.0	0.2	0.8	0.4	0.8	0.0	0.8	0.6	0.0
Forced vital capacity (FVC), Best measure	1.4	5.0	13.8	0.5	-3.0	3.7	1.8	2.4	-0.6	-3.2	-1.9	-1.3	-3.0	-0.9	-3.0	-2.7	-1.0	-2.1	-2.2	-1.8	-1.4
Body fat percentage	0.1	0.4	3.7	-0.9	0.7	-1.9	-0.8	-0.4	0.5	0.1	0.1	-0.0	0.0	-0.1	0.5	0.4	0.4	-0.2	0.4	0.4	-0.1
Leg fat percentage (right)	0.1	0.3	1.8	-0.3	1.3	-1.2	-0.5	-0.2	0.4	0.4	0.0	-0.1	0.0	-0.0	0.4	0.3	0.4	-0.1	0.3	0.5	-0.2
Arm fat-free mass (right)	0.2	1.2	3.0	0.3	-0.9	-0.0	1.0	1.7	-0.6	-1.1	-0.9	-1.3	-1.6	-0.5	-1.4	-1.1	-0.6	-1.7	-1.0	-1.3	-0.9
Exposure to tobacco smoke outside home	1.4	1.8	5.9	2.4	1.0	-0.0	2.1	1.3	-1.2	0.7	-1.7	-1.5	-1.5	-1.4	-0.4	-1.6	-0.8	-1.4	-0.9	-0.3	-1.7
Comparative body size at age 10	0.8	2.2	4.7	1.6	-1.4	-0.2	1.7	1.9	-1.3	-1.4	-0.7	-1.4	-1.2	-1.0	-2.2	-1.2	-0.9	-1.4	-2.1	-2.0	-1.4
Number of full brothers	0.6	0.8	3.7	1.4	0.2	1.9	1.4	1.2	-0.6	-0.4	-1.4	-0.0	-0.6	-0.6	-0.4	-1.1	-0.2	-0.3	-0.6	-0.0	-0.3
Worry too long after embarrassment	0.7	1.2	4.5	-1.1	-0.7	-1.4	-1.0	-1.1	-0.1	0.1	2.1	0.4	1.6	0.5	1.0	1.3	0.2	1.3	1.2	0.7	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	3.4	0.4	-1.9	1.2	1.1	1.0	-0.3	-1.8	-1.2	-0.6	-1.6	-0.8	-1.8	-1.4	-0.4	-1.6	-1.2	-1.4	-1.1
Wheeze or whistling in the chest in last year	1.1	2.0	3.9	1.0	-1.6	2.0	1.6	1.7	-1.5	-1.6	-1.3	-0.8	-1.1	-1.6	-1.6	-1.8	-1.1	-1.1	-1.5	-1.1	-0.7
Number of children fathered	2.1	2.4	4.0	-1.5	1.5	0.3	-1.9	-1.7	1.5	1.7	1.4	1.4	1.8	1.5	1.6	2.0	1.3	1.6	1.5	1.3	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.5	1.4	-0.3	-1.0	1.4	1.6	-1.6	-1.1	-0.3	-0.6	0.1	-1.0	-0.3	-0.5	-0.7	-0.2	-0.6	-0.7	0.3
Age at first live birth	0.4	0.7	2.7	-0.9	-1.2	0.4	-0.4	-0.3	0.0	-1.6	0.4	-1.1	-1.4	-0.2	-0.8	-0.9	-0.5	-0.6	-0.4	-0.1	-1.2
Pulse wave peak to peak time	0.6	0.7	3.6	-1.9	-0.1	0.7	-1.4	-1.2	0.9	-0.9	0.6	1.0	0.1	0.4	0.5	0.5	0.6	0.5	0.7	0.6	0.4
Health satisfaction	0.3	0.3	1.4	0.0	1.2	-0.1	-0.3	-0.4	0.4	0.7	0.7	0.5	0.9	0.5	0.3	1.2	0.4	-0.0	0.4	-0.4	0.3
Shortness of breath walking on level ground	0.4	0.5	2.2	0.3	-0.2	0.4	0.9	0.7	-0.3	-0.6	-1.5	0.3	-0.7	-0.8	-0.8	-0.9	0.0	-0.8	-0.7	-0.6	-0.6
Qualifications: College or University degree	0.5	1.5	12.1	-1.6	-3.5	0.2	-0.6	-0.7	0.1	-2.4	1.4	0.1	0.2	0.6	-1.2	-0.0	-0.2	0.3	-0.1	-0.8	0.9
Eye problems/disorders: None of the above	1.8	2.0	4.9	-2.0	-0.7	-0.7	-2.2	-2.0	1.3	-0.3	1.9	1.1	1.4	1.3	1.0	1.6	1.0	1.5	1.3	0.9	1.9
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.1	0.8	-0.0	0.5	1.1	0.4	-1.3	-0.9	-1.0	-0.6	-0.6	-1.4	-0.9	-0.7	-1.1	-1.1	-1.1	-1.2	-0.6
Emphysema/chronic bronchitis	2.0	2.2	5.8	2.4	0.3	-0.0	2.1	1.4	-2.4	-0.3	-2.1	-0.7	-0.8	-2.2	-0.6	-1.5	-2.0	-0.8	-1.5	-0.9	-1.0
Medication for pain relief, constipation, heartburn	0.7	1.1	3.3	-1.8	-0.9	-0.2	-1.4	-0.8	1.2	-0.7	1.4	0.2	0.5	1.4	0.7	0.5	1.0	1.0	1.4	1.3	1.2
Neck or shoulder pain in last month	0.4	0.6	2.5	-1.0	0.5	-0.8	-1.2	-1.6	0.4	0.5	0.4	0.3	0.6	0.2	1.0	0.5	0.0	0.6	1.0	0.8	-0.0
Medication: Blood pressure	0.9	1.5	4.8	1.4	0.4	0.7	1.0	0.3	-1.0	-0.2	-1.6	-0.9	-1.5	-1.4	-1.1	-1.3	-1.4	-1.3	-1.5	-1.1	-2.2
Angina (self-reported)	0.1	0.2	0.7	0.3	-0.1	-0.3	0.3	-0.7	0.2	-0.1	-0.8	0.1	-0.5	-0.3	-0.1	-0.6	-0.1	-0.1	-0.1	0.1	-0.8
Migraine (self-reported)	0.4	0.5	1.8	-1.4	-0.6	-0.7	-0.7	-0.7	0.9	0.1	1.2	-0.2	0.1	0.9	0.1	0.7	0.7	-0.2	0.7	0.0	0.1
Medication: Ibuprofen	1.5	1.8	7.2	0.4	-2.1	1.1	1.0	1.5	-0.9	-2.7	-0.9	-0.7	-1.4	-1.1	-1.6	-1.4	-0.8	-1.2	-1.5	-1.2	-0.7
Medication: Allopurinol	1.4	1.9	5.7	-0.5	1.3	-2.4	-0.7	-1.4	0.7	2.1	1.4	0.4	1.2	0.4	1.9	1.4	1.5	0.8	1.7	1.5	1.3
Medication: Omeprazole	0.3	0.4	1.4	1.2	0.3	-0.5	0.9	0.8	-0.5	0.2	-0.1	-0.7	-0.5	-0.6	-0.5	-0.3	-0.2	-0.8	-0.7	-0.7	-0.7
Medication: Seretide 50 evohaler	1.4	1.6	2.9	1.1	-0.2	1.5	1.7	1.6	-1.3	-0.4	-1.4	-0.7	-1.5	-1.5	-1.3	-1.5	-1.3	-1.3	-1.6	-0.9	-0.8
Mean time to correctly identify matches	0.5	1.0	3.8	0.5	1.9	-1.1	-0.1	-1.0	-0.3	1.7	0.2	0.9	1.5	-0.3	1.5	1.1	0.3	0.9	0.7	0.6	0.2
Heart disease (mother)	1.2	1.4	2.5	-1.2	0.0	-1.4	-1.3	-1.2	1.1	1.6	1.5	1.1	1.4	1.1	0.9	1.3	1.4	1.1	1.3	0.8	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.5	0.8	1.4	-0.4	0.2	0.4	0.1	1.6	-0.4	1.3	1.3	0.1	1.4	0.5	1.0	1.1	0.9	1.3	1.2
Whole body fat mass	0.1	0.3	1.9	-0.5	0.3	-1.4	-0.1	0.3	0.0	-0.4	-0.5	-0.5	-0.7	-0.6	-0.2	-0.3	-0.0	-1.0	-0.2	-0.3	-0.7
Leg fat mass (right)	0.1	0.4	1.2	-0.1	0.3	-0.9	0.2	0.7	-0.1	-0.5	-0.5	-0.9	-1.0	-0.5	-0.6	-0.5	-0.2	-1.1	-0.5	-0.5	-0.9
Arm predicted mass (right)	0.3	1.4	3.3	0.3	-1.0	0.1	1.0	1.8	-0.7	-1.1	-1.0	-1.4	-1.8	-0.7	-1.5	-1.3	-0.7	-1.8	-1.1	-1.4	-1.1
Pulse rate, automated reading	0.6	1.8	8.8	3.0	1.3	1.0	2.1	2.0	-1.0	0.6	-1.3	-1.1	-0.8	-0.3	-0.9	-0.6	-0.9	-1.0	-1.4	-1.2	-1.2
Alcohol intake frequency.	1.6	3.8	9.7	1.4	-0.2	0.9	1.9	1.2	-1.7	-0.3	-2.2	-2.2	-2.4	-2.0	-1.9	-2.2	-1.9	-2.5	-2.3	-1.9	-3.1
Comparative height size at age 10	0.8	4.3	10.6	2.7	-1.0	2.5	3.1	3.3	-1.2	-1.3	-2.7	-0.3	-1.9	-1.3	-2.5	-2.1	-0.8	-1.8	-2.4	-2.3	-1.4
Number of full sisters	0.3	0.4	2.8	0.8	1.0	-0.5	0.3	-0.4	0.0	1.7	-0.9	-0.1	0.1	-0.1	0.6	0.1	0.1	-0.1	0.1	0.2	-0.8
Suffer from ‘nerves’	0.6	0.9	2.0	0.1	-1.4	0.6	1.1	0.3	-0.5	0.0	-1.2	-0.4	-1.2	-1.1	-1.3	-1.4	-0.5	-1.2	-0.9	-0.8	-0.9
Overall health rating	0.8	1.7	5.4	0.2	2.3	-1.1	-0.9	-1.2	0.7	2.2	0.5	1.2	1.6	0.6	1.9	1.7	0.9	1.0	1.3	1.0	0.9
Chest pain or discomfort	0.6	0.8	2.5	-0.5	0.7	-0.3	-0.4	-1.6	0.6	0.2	0.2	1.3	1.3	0.5	1.1	0.9	1.0	1.0	1.1	0.9	0.9
Had major operations	0.7	0.8	3.6	1.2	0.0	1.3	1.9	0.5	-0.8	-1.1	-1.1	1.1	-0.0	-1.0	-0.6	-0.6	-0.1	-0.2	-0.8	-0.5	0.1
Age at last live birth	0.3	0.4	1.8	-0.7	-0.8	-0.2	-0.7	-0.7	-0.1	-1.3	0.7	-0.8	-0.8	-0.1	-0.3	-0.5	-0.6	0.1	-0.2	0.3	-0.8
Family relationship satisfaction	0.8	0.9	2.5	-1.2	0.5	-0.0	-1.1	-1.6	1.4	0.8	0.8	0.8	0.8	1.0	0.9	1.0	1.3	0.5	1.2	0.9	0.1
Leg pain on walking	0.7	0.8	2.5	0.2	0.7	-0.5	-0.4	-0.6	0.4	1.3	0.6	1.3	1.6	0.7	1.0	1.5	0.8	0.9	0.7	0.3	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.2	0.8	1.2	-1.5	0.1	0.7	-1.0	0.7	0.5	-1.2	0.1	-0.5	-0.0	0.5	-0.9	-0.9	-0.3	-0.9	-0.3
Commuting to job workplace: Car/motor vehicle	1.1	1.3	5.7	0.1	0.6	0.5	0.1	-0.1	-0.8	1.2	-1.6	-0.8	-1.3	-1.9	-0.4	-1.4	-1.1	-1.2	-0.7	0.0	-2.4
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.0	-1.7	-0.2	0.5	-1.4	-1.1	1.6	-0.1	1.6	0.4	0.5	1.2	0.4	0.8	1.2	0.9	0.8	1.0	1.0
Medication: Aspirin	0.4	0.6	2.6	0.9	1.3	-0.7	0.0	-0.4	-0.8	1.6	-0.2	-0.8	-0.2	-0.8	0.4	0.0	-1.1	-0.3	-0.4	-0.1	-1.1
Supplements: Vitamin C	0.4	0.5	1.6	0.7	-0.2	0.8	0.2	1.1	-0.2	-0.6	1.1	-0.2	0.8	0.9	-0.1	0.9	-0.1	0.5	-0.3	-0.8	1.3
Knee pain experienced in last month	0.2	0.3	0.9	-0.2	0.1	0.6	0.4	-0.1	-0.3	0.7	-1.0	0.4	-0.4	-0.9	-0.2	-0.2	-0.1	-0.8	-0.5	-0.4	-0.5
Hypertension (Self-reported)	0.1	0.4	5.5	-0.2	-0.3	-2.4	-0.5	-0.1	-0.0	-0.3	0.4	-0.2	0.2	-0.0	0.2	0.5	-0.2	-0.2	0.2	-0.3	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.1	1.1	0.4	-0.6	0.7	1.0	-1.1	-0.0	-0.2	-0.5	-0.1	-0.7	-0.4	-0.1	-0.8	-0.4	-0.8	-0.8	-0.1
Illnesses of father: Heart disease	0.1	0.1	0.4	-0.4	-0.2	-0.1	0.1	-0.6	0.0	0.4	-0.6	0.4	-0.2	-0.5	-0.1	-0.1	0.3	-0.5	-0.0	-0.2	-0.2
Illnesses of siblings: Diabetes	0.9	1.1	3.7	0.4	-0.0	-0.4	0.3	0.1	-1.3	0.2	-0.3	-1.8	-0.9	-1.5	-0.8	-0.7	-1.7	-1.3	-1.1	-1.1	-1.9
Smoking status: Previous	0.1	0.1	0.5	0.5	0.3	0.2	-0.1	0.4	0.5	0.3	-0.6	0.7	0.1	0.0	-0.1	0.3	0.4	-0.1	-0.2	-0.0	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	6.2	-0.4	-2.5	0.4	0.4	1.1	-0.1	-1.9	-0.5	-0.0	-0.9	-0.2	-1.5	-1.1	-0.3	-0.6	-0.7	-0.8	-0.1
Whole body fat-free mass	0.4	2.5	5.4	0.7	-1.2	0.8	1.6	2.1	-1.0	-1.3	-1.6	-1.6	-2.2	-1.1	-1.9	-1.7	-1.0	-2.3	-1.6	-1.9	-1.5
Leg fat-free mass (right)	0.4	2.2	5.5	-0.1	-1.6	-0.1	1.2	1.7	-0.8	-1.6	-1.2	-1.6	-2.2	-1.1	-1.8	-1.5	-0.8	-2.4	-1.4	-1.8	-1.5
Arm fat percentage (left)	0.1	0.5	4.4	-1.1	0.7	-2.1	-0.9	-0.5	0.7	0.2	0.4	-0.3	-0.1	0.2	0.5	0.4	0.5	-0.3	0.6	0.4	-0.3
Average weekly red wine intake	1.3	2.0	3.5	-0.3	1.7	-1.2	-0.7	-0.7	1.1	1.8	0.8	1.6	1.8	1.0	1.9	1.3	1.6	1.8	1.7	1.7	1.4
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.5	0.8	-0.0	0.9	1.0	0.8	-0.3	0.8	-1.6	-0.7	-1.3	-0.6	-0.3	-1.4	-0.2	-0.7	-0.5	0.3	-1.2
Mood swings	0.2	0.4	2.2	-1.4	-0.3	-0.8	-1.0	-1.5	-0.1	-0.4	0.4	0.4	0.1	-0.6	0.1	0.2	-0.7	-0.0	0.1	0.0	0.4
Loneliness, isolation	1.4	1.9	4.0	0.6	-1.9	0.1	1.4	1.1	-0.9	-0.9	-1.6	-0.9	-1.8	-1.3	-1.8	-2.0	-0.9	-1.8	-1.2	-1.5	-1.8
Long-standing illness, disability or infirmity	1.2	1.8	4.6	0.2	1.9	-0.4	-0.0	-1.4	1.3	2.0	-1.1	2.1	1.2	0.4	1.7	0.8	2.1	0.7	1.4	1.5	0.5
Ever had bowel cancer screening	2.5	2.9	5.6	-1.6	0.5	-0.7	-1.7	-1.8	2.1	0.4	1.5	2.3	2.0	1.9	1.4	1.8	2.4	1.8	1.9	1.5	2.0
Diabetes diagnosed by doctor	0.5	0.8	2.7	1.3	0.4	-0.2	1.0	0.8	-0.8	-0.1	-0.4	-0.9	-0.5	-0.4	-1.2	-0.3	-0.9	-1.0	-1.2	-1.6	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.2	0.3	0.9	-0.9	0.3	-0.0	-0.8	1.1	0.4	-0.0	0.8	-0.3	0.9	0.8	-0.4	0.1	0.5	0.0	1.1
Friendships satisfaction	0.3	0.4	1.8	-1.1	0.7	-1.3	-0.5	-0.2	-0.0	0.2	1.2	-1.0	-0.3	-0.1	0.4	0.1	-0.0	-0.1	0.3	0.7	-0.1
Qualifications: nursing, teaching	0.6	0.9	5.2	-0.8	-1.7	2.3	-0.5	-0.9	0.8	-1.4	-0.8	1.2	-0.2	0.1	-0.7	-0.4	0.2	0.2	-0.3	-0.1	-0.6
Commuting to job workplace: Walk	0.5	0.5	3.6	-0.3	-1.9	0.6	-0.2	0.1	0.3	-1.2	1.1	-0.3	-0.2	0.7	-0.6	-0.0	0.2	0.3	-0.1	-0.2	0.9
Eye problems/disorders: Cataract	0.6	0.7	2.0	1.3	1.0	-0.6	1.2	0.9	-0.8	0.9	-0.9	-0.8	-0.4	-0.8	-0.0	-0.6	-0.5	-0.6	-0.4	-0.2	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.1	0.1	0.9	-1.8	0.0	-0.5	0.1	1.3	0.6	1.1	1.6	0.3	1.3	1.5	1.0	0.5	1.2	0.3	1.7
Medication for cholesterol	1.4	2.1	8.6	0.3	-1.7	2.6	1.0	1.2	-0.9	-2.9	-1.2	-0.1	-1.2	-1.0	-2.0	-1.9	-0.9	-0.3	-1.7	-0.8	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.5	0.9	1.1	-1.1	0.5	0.5	0.7	0.0	0.7	1.0	1.1	0.8	0.4	1.0	1.2	0.7	0.5	0.1	1.2
Back pain experienced in last month	0.6	0.8	2.1	-0.2	1.0	-1.4	-0.3	-0.1	0.2	1.1	0.2	1.1	1.4	-0.2	1.2	0.8	1.0	0.8	1.0	1.0	1.0
Mineral and other dietary supplements	0.3	0.4	3.2	-0.2	-0.3	-1.8	-0.7	-1.1	0.3	-0.0	0.4	-0.6	-0.1	0.3	0.4	-0.1	-0.3	0.1	0.6	0.3	-0.9
Breast cancer (self-reported)	0.7	0.9	2.3	-0.5	-0.0	1.5	0.6	0.7	-0.5	-0.6	-1.0	-0.5	-1.3	-0.9	-1.4	-1.1	-0.8	-1.1	-1.3	-0.8	-0.7
Asthma (self-reported)	1.0	2.0	4.3	1.0	-0.8	0.7	1.1	1.0	-1.1	-0.6	-1.4	-1.7	-1.9	-1.8	-1.3	-1.8	-1.6	-1.8	-1.3	-1.0	-2.1
Osteoporosis (self-reported)	0.2	0.2	1.2	0.6	0.4	-1.1	0.5	0.4	-0.2	0.2	0.6	-0.3	0.3	0.0	-0.3	0.5	0.2	-0.3	-0.4	-0.7	0.2
Osteoarthritis (self-reported)	3.3	4.3	8.5	-0.8	2.6	-0.2	-1.9	-1.4	1.7	2.8	1.3	1.9	2.6	1.8	2.9	2.6	1.8	2.4	2.2	2.4	1.7
Medication: Aspirin	0.4	0.6	1.9	1.1	1.2	-0.4	0.4	-0.1	-0.8	1.4	-0.5	-0.7	-0.3	-0.8	0.2	-0.2	-1.1	-0.3	-0.5	-0.2	-1.1
Medication: Gliclazide	0.1	0.1	1.4	-0.0	0.0	-1.2	-0.5	-0.5	0.1	-0.3	0.2	-0.4	-0.1	0.1	-0.0	0.0	-0.3	0.0	-0.0	-0.0	-0.3
Illnesses of father: None of the above (group 1)	0.2	0.3	0.9	-0.8	-0.4	-0.0	-0.5	-0.6	0.9	-0.8	-0.1	0.0	-0.3	0.3	0.4	-0.2	0.8	0.1	0.6	0.9	-0.3
Smoking status: Current	0.1	0.2	0.7	-0.0	-0.3	-0.1	-0.1	0.4	-0.1	-0.9	0.8	-0.8	0.0	0.2	0.1	-0.2	-0.2	0.7	0.0	0.7	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.2	-1.4	-0.5	1.2	-0.9	-0.5	1.2	-0.3	0.7	1.2	0.4	1.5	0.5	0.6	1.1	1.0	0.8	0.8	1.4
Whole body water mass	0.4	2.3	4.9	0.6	-1.2	0.8	1.6	2.1	-0.9	-1.3	-1.6	-1.5	-2.2	-1.0	-1.8	-1.7	-0.9	-2.2	-1.6	-1.8	-1.4
Leg predicted mass (right)	0.4	2.1	5.5	-0.1	-1.6	-0.0	1.1	1.6	-0.7	-1.6	-1.2	-1.6	-2.2	-1.0	-1.8	-1.5	-0.8	-2.3	-1.4	-1.7	-1.5
Arm fat mass (left)	0.1	0.3	2.7	-0.8	0.5	-1.7	-0.4	0.2	0.4	0.1	-0.1	-0.6	-0.5	-0.0	0.1	0.0	0.3	-0.8	0.1	-0.1	-0.6
Number of self-reported non-cancer illnesses	0.5	0.8	3.5	1.4	1.8	0.1	1.1	-0.0	-0.4	1.9	-1.3	0.9	0.7	-0.6	0.7	0.5	0.4	-0.3	0.1	-0.2	0.2
Average weekly champagne plus white wine intake	1.3	1.7	4.8	-1.1	0.3	-2.2	-1.4	-1.1	0.6	0.1	1.6	0.9	1.8	0.9	1.6	1.6	1.1	1.3	1.7	1.1	1.4
Miserableness	0.4	0.6	2.3	-0.7	-1.3	1.0	0.2	-0.1	-0.6	-1.3	-0.1	0.5	0.1	-0.6	-1.2	0.1	-0.6	-0.8	-0.7	-1.5	0.1
Guilty feelings	0.2	0.2	0.8	-0.2	0.5	0.6	0.3	-0.2	0.1	0.2	0.6	0.6	0.5	0.3	0.6	0.2	0.2	0.9	0.5	0.7	0.8
Wears glasses or contact lenses	3.2	3.6	12.7	-1.2	0.7	0.8	-0.6	-1.2	2.7	0.4	0.5	3.6	1.9	2.2	1.0	1.6	3.4	2.1	1.6	1.8	2.7
Ever taken oral contraceptive pill	0.3	0.4	1.5	-0.5	-0.5	-0.7	-0.2	-0.3	0.1	-0.3	0.0	1.0	0.5	-0.2	0.6	0.1	0.3	0.8	0.7	0.9	1.2
Hearing aid user	0.3	0.4	1.3	0.6	1.1	-0.3	1.1	0.4	0.1	1.1	-1.1	0.3	-0.5	-0.4	-0.0	-0.5	0.6	-0.5	-0.2	0.1	-0.0
Mother’s age at death	0.3	0.4	2.5	-0.3	-0.4	1.2	0.3	-0.9	0.3	-1.6	-0.4	1.1	0.1	-0.1	-0.7	-0.2	0.3	0.4	-0.5	-0.2	0.1
Financial situation satisfaction	2.8	3.5	5.7	-1.6	1.6	0.0	-1.8	-2.1	1.9	1.4	1.6	1.8	2.2	2.0	2.2	2.4	2.0	1.9	2.2	1.7	2.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.8	1.2	0.5	-0.2	1.3	0.8	-1.1	0.5	-0.4	-0.6	-0.2	-0.9	-0.7	-0.1	-0.5	-1.0	-0.8	-1.3	-0.1
Commuting to job workplace: Public transport	1.0	1.1	3.6	-0.6	-1.4	-0.7	-0.7	-0.4	0.9	-1.2	1.2	1.1	1.3	1.6	0.2	1.2	0.9	1.3	0.6	0.0	1.9
Eye problems/disorders: Glaucoma	2.1	2.5	4.6	1.2	-1.1	0.7	1.6	1.2	-1.5	-0.4	-1.8	-1.5	-2.0	-2.1	-1.7	-2.1	-1.4	-2.1	-1.6	-1.4	-2.1
Medication: Blood pressure	0.6	1.1	11.9	-0.8	-0.2	-3.4	-1.0	-0.3	0.0	0.5	1.6	-1.3	0.3	0.2	0.8	0.8	-0.2	-0.1	0.8	0.3	-0.1
Pain type(s) experienced in last month: Hip pain	0.8	1.0	4.2	1.8	1.7	-0.1	0.7	0.4	-1.2	2.1	-1.0	-0.0	0.5	-0.9	0.4	0.8	-0.8	-0.7	-0.6	-1.0	-0.5
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.9	0.8	-0.5	1.2	1.4	1.5	-1.3	-0.3	-1.3	-0.6	-1.1	-1.7	-1.1	-1.2	-0.6	-1.3	-1.3	-1.0	-0.4
High cholesterol (Self-reported)	1.0	1.8	7.8	-0.4	2.8	-1.2	-0.8	-1.6	0.9	2.0	0.5	0.7	1.2	0.9	1.9	1.4	0.9	1.2	1.3	1.4	0.2
Medication: Bendroflumethiazide	1.9	2.8	5.9	1.7	-0.8	1.1	1.5	1.7	-1.2	-0.3	-2.0	-1.5	-2.1	-1.7	-1.8	-1.8	-1.2	-2.2	-2.1	-1.7	-2.4
Medication: Paracetamol	0.2	0.3	2.0	0.5	0.1	-0.7	-0.0	-0.4	-0.0	1.4	-1.0	0.6	0.3	-0.5	-0.1	0.1	-0.1	-0.4	-0.2	-0.6	-0.7
Medication: Lisinopril	0.3	0.4	1.8	-1.4	-0.1	-1.0	-1.2	-0.4	0.8	-0.2	1.1	-0.8	-0.4	0.5	-0.0	0.2	0.6	-0.3	0.4	0.1	-0.4
Medication: Atorvastatin	0.4	0.5	1.5	1.2	0.9	0.5	1.1	1.2	-0.5	0.5	-0.5	-0.7	-0.6	-0.3	-0.6	-0.3	-0.5	-0.9	-0.7	-1.0	-0.5
Illnesses of father: High blood pressure	0.2	0.2	0.9	0.2	-0.4	-0.6	-0.2	0.2	-0.2	0.1	0.9	0.3	0.9	0.4	0.0	0.5	0.1	0.7	0.2	-0.2	0.8
Alcohol drinker status: Never	0.3	0.3	1.7	-0.5	-1.1	-0.5	0.1	0.3	-0.3	0.3	0.3	-1.3	-0.8	-0.2	-0.6	-0.5	-0.2	-0.8	-0.3	-0.4	-0.3
Ever smoked	0.1	0.1	0.6	0.2	0.1	0.3	-0.2	0.2	0.1	0.3	-0.4	0.6	0.3	-0.3	0.3	0.1	0.1	0.4	0.0	0.6	0.8
Basal metabolic rate	0.4	1.9	4.8	0.3	-1.0	0.3	1.3	1.8	-0.8	-1.2	-1.4	-1.5	-2.1	-1.0	-1.6	-1.5	-0.8	-2.2	-1.4	-1.6	-1.5
Leg fat percentage (left)	0.1	0.5	2.5	-0.6	1.2	-1.6	-0.9	-0.4	0.6	0.3	0.5	0.1	0.4	0.3	0.7	0.6	0.6	0.3	0.6	0.7	0.3
Arm fat-free mass (left)	0.3	1.5	3.5	0.6	-0.6	0.8	1.3	1.9	-0.7	-0.8	-1.4	-1.2	-1.8	-0.7	-1.5	-1.4	-0.7	-1.8	-1.3	-1.4	-1.2
Number of operations (self-reported)	0.4	0.6	3.3	0.9	1.8	-0.5	0.5	-0.5	0.0	0.9	-0.2	1.0	0.8	0.0	0.9	0.7	0.6	0.4	0.5	0.3	0.7
Average weekly beer plus cider intake	1.1	1.6	3.7	1.7	-1.0	1.9	1.5	1.1	-1.4	-0.7	-1.7	-0.3	-0.9	-1.4	-1.1	-1.3	-1.4	-1.0	-1.4	-1.3	-0.7
Irritability	0.9	1.5	7.0	-1.3	0.2	-2.6	-0.9	-1.4	0.1	0.2	1.1	0.9	1.4	0.1	1.6	1.0	0.6	1.2	1.5	1.4	1.4
Risk taking	0.7	1.0	3.4	0.1	-1.3	-1.0	1.1	0.9	-1.0	-1.3	-0.8	-1.0	-1.2	-1.5	-0.6	-1.9	-0.6	-0.7	-0.4	0.2	-0.7
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.1	0.5	-0.6	0.4	0.8	0.0	-1.2	-0.5	-1.3	0.3	-0.4	-1.4	-0.5	-0.9	-0.9	-0.6	-0.7	-0.8	-0.7
Fractured/broken bones in last 5 years	1.5	1.9	3.5	1.5	0.6	-0.2	1.6	1.4	-1.7	0.3	-1.2	-1.5	-1.1	-1.6	-1.0	-1.0	-1.9	-1.6	-1.6	-1.7	-1.5
Age started oral contraceptive pill	0.3	0.4	0.9	0.4	-0.5	-0.6	0.8	-0.2	-0.5	-0.5	-0.4	-0.9	-0.8	-0.5	-0.9	-0.8	-0.5	-0.8	-0.8	-0.7	-0.7
Diastolic blood pressure, automated reading	0.5	1.7	6.1	2.5	2.0	-0.5	1.3	1.9	-1.5	1.1	-0.6	-1.7	-0.5	-0.7	-0.2	-0.3	-1.2	-1.1	-0.9	-1.1	-1.5
Ever depressed for a whole week	0.3	0.4	1.6	-0.2	0.7	0.4	-0.0	-0.3	0.1	0.4	-0.1	1.3	0.9	-0.0	0.9	0.4	0.3	1.0	0.5	0.8	0.9
Unable to work because of sickness or disability	0.2	0.3	1.1	0.7	0.7	-0.1	-0.2	-0.3	0.2	0.4	-0.4	0.7	0.6	0.3	1.0	0.4	0.3	0.7	0.6	0.8	0.5
Commuting to job workplace: Cycle	1.4	1.7	3.8	0.5	-1.9	1.6	1.6	0.9	-0.6	-1.3	-2.0	0.8	-1.3	-0.7	-1.8	-1.3	-0.7	-1.3	-1.3	-1.7	-0.1
Myopia	0.3	0.5	2.8	-0.7	-1.7	-1.6	-0.6	-0.4	0.0	-0.2	0.5	-0.8	-0.2	-0.2	-0.3	-0.4	0.0	-0.4	0.5	-0.1	-0.4
Vascular/heart problems diagnosed by doctor	0.1	0.4	4.5	-0.1	-0.1	2.1	0.2	0.1	0.2	-0.3	-0.2	0.3	0.0	0.3	0.0	-0.5	0.5	0.6	0.2	0.7	0.4
Cholesterol lowering medication	0.7	1.1	3.1	-0.4	1.8	-0.6	-0.4	-1.1	1.2	1.6	0.7	0.5	1.0	1.4	1.1	1.6	1.3	0.4	1.0	0.4	0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.6	0.7	0.5	-0.4	0.6	0.8	-0.2	0.6	0.2	-0.1	0.1	-0.1	0.0	0.2	0.2	-0.2	-0.1	-0.2	0.2
Pain experienced in last month	0.6	0.9	4.4	-0.1	-2.1	0.6	0.1	0.4	-0.3	-1.8	0.3	-1.3	-1.3	0.0	-1.2	-1.2	-0.8	-0.4	-0.7	-0.4	-0.5
Supplements: Calcium	0.7	0.8	3.5	1.9	0.4	-0.9	1.4	1.1	-0.8	-0.2	0.5	0.4	1.3	0.1	-0.3	0.8	0.1	0.5	-0.5	-1.0	1.0
Basal cell carcinoma (self-reported)	3.5	4.2	11.2	-2.3	0.9	-2.2	-2.9	-3.3	2.3	1.2	2.2	1.7	2.0	1.9	1.9	2.5	1.5	1.9	1.9	1.3	1.2
Heart attack/myocardial infarction (self-reported)	0.2	0.3	2.0	1.4	0.9	-0.0	0.8	0.3	-0.4	1.2	-0.1	-0.0	0.1	0.0	-0.0	0.2	-0.0	0.1	-0.4	-0.3	0.0
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	4.9	1.5	-1.4	0.4	1.1	1.9	-0.8	-0.6	-0.3	-2.2	-1.8	-0.1	-1.8	-1.1	-1.2	-1.8	-1.5	-1.8	-1.3
Heart disease (siblings)	0.8	1.0	2.2	0.0	1.2	-0.6	-0.2	-1.2	0.9	1.5	1.1	0.8	1.2	1.2	0.9	1.2	1.4	1.0	0.9	0.7	0.7
Alcohol drinker status: Previous	0.8	0.9	1.7	0.8	-0.8	1.1	0.8	1.0	-0.7	-0.4	-0.9	-0.9	-0.8	-0.5	-1.1	-0.9	-1.1	-0.9	-1.1	-1.1	-1.3
Pack years of smoking	1.6	2.3	4.1	2.0	-1.6	-0.0	2.0	1.3	-2.0	-1.3	-1.2	-1.4	-1.0	-1.7	-1.6	-1.8	-1.7	-1.2	-1.5	-1.6	-1.3
Impedance of whole body	0.4	1.9	5.8	-0.1	0.7	-0.0	-0.9	-1.8	0.9	1.0	0.6	2.4	2.0	0.7	1.5	1.4	1.2	2.0	1.3	1.5	1.7
Leg fat mass (left)	0.1	0.2	1.4	-0.3	0.4	-1.2	-0.1	0.5	0.1	-0.5	-0.2	-0.6	-0.6	-0.2	-0.3	-0.2	0.1	-0.8	-0.2	-0.3	-0.5
Arm predicted mass (left)	0.3	1.7	3.9	0.6	-0.6	1.1	1.3	2.0	-0.7	-0.9	-1.4	-1.2	-1.9	-0.7	-1.5	-1.4	-0.7	-1.9	-1.3	-1.5	-1.2