Hub : Genes

RP11-46A10.4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Liver	0.195	0.0690	0.00320	0.017	NA	0.061	NA	0.041	1.1e-01	NA	8.9e-03	NA	2.7e-02
2	GTEx	Nerve Tibial	0.200	0.0635	0.00016	0.077	NA	0.046	NA	0.078	3.9e-06	NA	3.1e-04	NA	3.6e-06
3	GTEx	Whole Blood	0.119	0.0380	0.00045	0.117	NA	0.089	NA	0.104	6.3e-11	NA	1.4e-08	NA	8.6e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.8	1.3	2.7	0.9	-0.5	-1.6
Bipolar Disorder or Schizophrenia	0.4	0.9	2.3	1.5	-0.5	-0.3
Depressed Affect (Nagel 2018)	0.6	1.2	2.0	-0.6	1.4	1.1
Depression (Nagel 2018)	0.4	0.6	0.7	0.8	-0.6	0.8
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.7	-1.3	0.8	-0.6
Neuroticism (Nagel 2018)	0.4	0.9	2.1	-0.4	0.7	1.5
Schizophrenia (2018)	0.4	0.8	1.4	1.2	-0.3	1.0
Schizophrenia vs Biploar Disorder	0.4	0.5	0.6	0.6	-0.8	0.7
Worry (Nagel 2018)	0.7	1.5	2.8	-0.5	1.2	1.7
Alzheimer’s Disease (in mother)	3.1	3.7	5.2	2.3	-1.3	2.0
Alzheimer’s Disease (in father)	1.5	1.6	2.4	1.6	-0.8	1.4
Alzheimer’s Disease (including proxy)	6.2	9.0	15.6	4.0	-2.3	2.4
Crohns Disease (2017)	0.3	0.7	1.2	-1.1	-0.0	-0.9
Irritable Bowel Disease (IBD)	0.2	0.5	0.7	-0.8	0.0	-0.9
Ulcerative Colitis (UC)	0.0	0.0	0.0	-0.0	0.1	-0.2
Major Depression (MDD)	0.4	0.5	0.8	-0.8	-0.9	0.1
Reaction Time	1.0	2.0	3.8	1.2	-1.9	0.8
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.4	-0.6	-0.6	-0.5
Breast Cancer	0.3	0.6	0.8	0.8	-0.9	0.7
Ovarian Cancer	0.3	0.4	1.1	-1.1	0.3	0.0
Prostate Cancer	0.4	0.6	0.9	-0.9	0.4	1.0
Age at First Birth	0.9	1.3	2.8	-1.1	1.7	-0.1
Bipolar Disorder (2011)	1.7	1.7	3.5	1.2	-1.9	0.5
Body Mass Index (BMI) (2010)	0.0	0.1	0.2	-0.1	-0.0	-0.4
Coronary Artery Disease (CAD)	0.6	0.7	1.6	0.5	0.4	-1.3
Crohns Disease (2012)	0.1	0.1	0.3	-0.3	-0.5	-0.1
Mean Putamen Volume	1.1	1.2	2.0	-1.2	1.4	0.4
Fasting Glucose	0.9	1.1	3.1	0.2	0.3	1.8
HbA1C	1.1	1.3	1.8	1.3	-1.0	1.0
HDL Cholesterol	0.1	0.2	0.2	-0.5	0.3	-0.5
LDL Cholesterol	0.4	0.7	1.1	1.0	0.1	-1.0
Lupus	3.4	5.1	10.6	-3.3	1.9	-1.0
Neuroticism (2016)	0.5	0.7	1.4	-0.8	-1.2	0.1
Primary Biliary Cirrhosis	0.5	0.7	1.7	1.3	-0.6	0.2
Rheumatoid Arthritis	0.5	0.6	1.5	-0.1	1.2	-0.6
Schizophrenia (2014)	0.1	0.3	0.4	0.4	-0.6	0.6
Triglycerides	0.3	0.6	0.9	0.5	-0.9	0.7
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.4	0.8	-0.5	-1.2
Ulcerative Colitis	0.6	0.9	1.3	0.8	-1.2	0.8
Blood Eosinophil Count	0.8	6.3	13.5	2.3	-3.7	0.5
Blood Platelet Count	0.1	0.8	2.3	-0.4	-1.5	0.0
Blood Red Count	0.1	1.2	3.2	0.7	-1.8	0.1
Blood White Count	0.2	1.2	3.1	-0.5	-1.8	0.4
Heel T-Score	0.3	2.7	6.8	-2.6	0.1	-1.2
BMI	0.1	0.4	0.9	-0.3	0.4	-1.0
Height	0.5	10.3	18.1	-4.3	3.5	0.3
Waist Hip Ratio (WHR)	0.1	0.5	0.9	0.7	-1.0	-0.4
Systolic Blood Pressure	0.8	3.8	9.5	-0.8	-1.1	-3.1
Smoking Status	0.2	0.4	0.9	-0.0	-0.9	-0.6
Allergy or Eczema	0.5	1.4	3.0	0.7	-1.7	0.8
Cardiovascular Disease	0.0	0.1	0.2	-0.1	-0.0	-0.5
Hypothyroidism (self reported)	0.7	1.6	4.0	0.6	0.7	2.0
Respiratory disease	0.1	0.3	0.5	-0.7	0.2	-0.6
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.5	-0.7	0.7	-0.1
Lung FEV1/FVC ratio	2.5	12.8	23.4	4.8	-3.4	1.9
Lung FVC	0.5	2.4	4.1	-2.0	1.6	0.8
Neuroticism	0.4	1.0	1.6	-0.3	1.1	1.3
Chronotype (morning person)	1.2	2.9	5.3	-2.3	1.6	-0.9
Hair Pigment	0.0	1.0	1.6	1.3	-1.0	0.6
Tanning	0.3	3.1	6.4	-2.5	1.6	-0.6
Hand grip strength (left)	1.0	2.7	3.0	-1.7	1.5	-1.7
Number of treatments/medications taken	0.2	0.4	0.8	0.9	0.3	0.5
Average weekly spirits intake	0.7	0.9	1.6	-1.3	-1.0	0.1
Sensitivity / hurt feelings	0.7	1.2	2.2	-1.5	1.1	-0.4
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.3	-0.1	1.1	0.1
Hearing difficulty/problems: Yes	0.3	0.5	1.0	1.0	-0.6	-0.0
Relative age of first facial hair	0.2	0.4	0.6	-0.1	-0.8	-0.8
Other serious medical condition/disability diagnosed by doctor	4.3	5.6	7.3	2.7	-2.1	2.2
Ever used hormone-replacement therapy (HRT)	12.3	15.7	29.4	5.4	-2.9	3.0
Ever had hysterectomy (womb removed)	1.0	1.1	1.9	1.2	-1.4	-0.1
Systolic blood pressure, automated reading	0.2	0.5	0.9	-0.6	0.5	-1.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	0.6	0.8	-0.2
Angina	0.4	0.6	1.1	0.7	-0.3	-1.1
Medication for hormone replacement therapy	5.1	5.7	7.5	2.5	-1.9	2.7
Vitamin and mineral supplements	0.1	0.1	0.2	0.5	-0.3	0.1
Supplements: Zinc	1.6	1.8	4.4	2.1	-0.4	0.8
Medication: Co-codamol	1.1	1.3	2.6	1.6	-1.0	0.7
Medication: Metformin	0.2	0.3	0.5	-0.6	0.0	-0.7
Diabetes (father)	1.4	1.8	2.5	1.5	-1.6	0.7
Diabetes (mother)	2.6	3.4	5.7	2.4	-0.7	1.9
Severe depression (siblings)	1.1	1.2	3.3	0.6	-1.8	0.3
Pack years adult smoking proportion	0.3	0.4	0.5	-0.5	0.7	0.7
Impedance of leg (right)	0.4	1.9	3.8	2.0	-1.4	0.2
Leg fat-free mass (left)	0.5	2.7	4.6	-1.8	2.1	-0.4
Trunk fat percentage	0.1	0.5	1.3	-0.2	0.4	-1.1
Hand grip strength (right)	0.5	1.3	1.8	-1.4	1.0	-1.0
Townsend deprivation index at recruitment	0.2	0.2	0.3	-0.3	0.6	-0.5
Current tobacco smoking	0.5	0.8	1.5	-0.6	-1.2	0.7
Average weekly fortified wine intake	1.3	1.6	3.0	-1.7	-1.3	0.0
Maternal smoking around birth	0.0	0.1	0.1	0.3	-0.3	-0.2
Fed-up feelings	0.2	0.3	0.5	0.5	0.7	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	3.0	4.0	2.0	-2.0	1.0
Relative age voice broke	0.4	0.6	1.3	-1.1	0.3	-0.6
Taking other prescription medications	0.8	1.2	2.1	1.4	-0.3	1.2
Age when periods started (menarche)	0.3	0.6	1.3	-0.6	-0.5	1.1
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.8	0.5	0.0	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.4	-0.7	-0.5	0.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.0	-0.6	1.0	-0.7
Qualifications: CSEs or equivalent	0.7	1.0	2.0	-0.2	1.4	-0.9
Serious illness, injury or assault to yourself	0.3	0.3	0.7	0.2	-0.8	-0.4
High blood pressure	0.2	0.7	1.6	-1.2	0.5	-0.4
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.4	0.5	-0.7	0.4
Multivitamins +/- minerals	0.3	0.4	0.8	-0.6	0.9	-0.1
Stomach or abdominal pain in last month	1.0	1.2	1.9	1.4	-1.2	0.5
Supplements: Glucosamine	0.6	0.8	1.1	0.8	-1.1	0.8
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.6	1.9	0.4	0.1
Medication: Atenolol	0.2	0.3	0.5	-0.3	0.5	0.7
Medication: Levothyroxine sodium	0.4	0.7	1.3	-0.1	1.1	0.9
Sitting height	0.9	6.1	12.4	-2.1	3.5	-1.2
Chronic bronchitis/emphysema (father)	0.5	0.6	1.7	0.1	0.2	1.3
High blood pressure (mother)	0.1	0.2	0.4	0.6	0.4	-0.2
Body mass index (BMI)	0.0	0.1	0.3	-0.3	0.3	-0.5
Impedance of leg (left)	0.3	1.2	2.3	1.5	-1.2	0.2
Leg predicted mass (left)	0.5	2.6	4.5	-1.8	2.1	-0.4
Trunk fat mass	0.2	0.8	1.1	-0.6	1.0	-1.1
Waist circumference	0.0	0.0	0.1	0.2	0.2	-0.3
Number of incorrect matches in round	0.4	0.6	0.9	0.9	0.8	-0.6
Past tobacco smoking	0.8	1.5	3.7	-1.9	0.5	0.8
Alcohol usually taken with meals	1.5	2.4	3.2	1.8	-1.6	1.2
Nervous feelings	1.7	3.2	6.3	-1.4	2.5	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.0	0.0	-1.0	0.2
Hearing difficulty/problems with background noise	0.2	0.4	0.9	1.0	-0.3	-0.4
Hair/balding pattern: Pattern 2	0.6	0.8	2.1	-0.1	-1.4	0.5
Had menopause	7.3	9.1	13.9	3.7	-2.8	2.4
Had other major operations	0.6	0.7	1.3	0.9	0.0	1.1
Forced vital capacity (FVC)	1.1	4.3	6.8	-2.6	2.4	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.8	-1.3	0.5	-0.2
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.7	-1.6	0.2	-0.2
Qualifications: None of the above	0.6	1.3	2.9	1.1	-1.7	-0.1
Financial difficulties in last 2 years	1.0	1.4	2.1	1.2	-1.4	-0.9
Mouth/teeth dental problems	1.8	2.7	5.7	-2.4	1.4	-0.6
Heart attack	1.4	1.8	4.4	2.1	-0.9	0.5
Allergy	0.0	0.0	0.1	0.2	0.1	0.2
Pain all over the body in last month	1.9	2.1	5.2	1.0	-0.1	2.3
Diabetes (self-reported)	0.1	0.1	0.3	-0.4	0.5	-0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	0.4	0.4	0.6
Medication: Ramipril	0.4	0.5	1.3	0.1	-1.1	-0.5
Medication: Simvastatin	0.6	0.8	1.0	0.8	-0.9	1.0
Fluid intelligence score	0.2	0.4	0.5	-0.6	-0.6	-0.7
Illnesses of siblings	0.7	0.9	2.3	-1.5	0.6	-0.4
Neuroticism score	0.4	0.9	2.2	-0.6	1.5	0.3
Weight	0.3	1.4	2.6	-1.1	1.6	-0.5
Impedance of arm (right)	0.1	0.6	1.0	0.9	-1.0	0.1
Arm fat percentage (right)	0.1	0.3	0.7	-0.3	0.3	-0.8
Trunk fat-free mass	0.4	2.1	4.3	-1.4	2.1	-0.1
Hip circumference	0.3	1.3	1.8	-1.4	0.7	-1.2
Time employed in main current job	0.4	0.5	1.3	-0.2	-1.1	-0.3
Alcohol intake versus 10 years previously	1.2	1.7	5.0	2.2	0.3	-0.3
Father’s age at death	1.7	2.3	3.1	1.6	-1.8	1.0
Worrier / anxious feelings	0.2	0.5	1.0	1.0	-0.2	0.6
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.8	5.8	2.2	-2.4	0.9
Falls in the last year	0.5	0.7	1.9	0.2	0.4	1.4
Hair/balding pattern: Pattern 3	0.4	0.7	1.3	0.1	1.2	-0.8
Number of live births	3.0	4.3	8.1	2.2	-2.8	0.4
Forced expiratory volume in 1-second (FEV1)	0.3	1.2	1.8	-1.3	1.3	0.1
Pulse rate	0.5	0.9	2.5	0.4	-1.6	0.2
Happiness	1.4	1.7	4.5	2.1	-0.7	0.1
Noisy workplace	0.3	0.3	0.6	0.6	-0.3	-0.7
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.7	-0.2	-0.4	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.6	1.3	-0.7	0.9
Mouth/teeth dental problems: Dentures	0.6	1.0	1.4	1.2	0.7	1.1
Asthma	0.3	0.6	0.8	-0.6	0.9	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	-0.3	0.1	0.2
Medication: Cholesterol lowering	0.2	0.2	0.4	0.5	-0.2	0.6
Depression (self-reported)	0.1	0.1	0.3	-0.6	0.0	0.1
Medication: Lansoprazole	1.8	2.1	3.1	1.1	-1.4	1.8
Prospective memory result	1.2	1.5	3.2	-0.1	1.2	-1.8
Lung cancer (father)	0.2	0.2	0.3	0.4	-0.6	0.2
Illnesses of mother	2.4	2.9	4.9	-2.2	1.6	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	3.8	-1.9	1.4	0.1
Pulse wave Arterial Stiffness index	0.2	0.2	0.6	0.8	-0.0	-0.3
Impedance of arm (left)	0.2	0.9	1.4	1.0	-1.2	-0.3
Arm fat mass (right)	0.1	0.4	0.5	-0.6	0.5	-0.7
Trunk predicted mass	0.3	1.9	4.0	-1.2	2.0	-0.0
Standing height	0.4	4.2	9.5	-1.8	3.1	-0.1
Length of working week for main job	0.8	0.8	1.1	0.8	0.9	1.1
Exposure to tobacco smoke at home	0.8	0.9	1.6	-0.5	1.3	-0.8
Breastfed as a baby	1.4	1.7	3.2	-1.8	1.3	0.5
Tense / ‘highly strung’	0.5	0.8	1.6	0.5	-0.7	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.0	-0.6	-0.0	1.4
Hair/balding pattern: Pattern 4	0.2	0.4	0.8	-0.6	0.3	-0.9
Birth weight of first child	0.6	1.0	1.6	-1.3	1.2	0.2
Peak expiratory flow (PEF)	0.3	0.7	1.7	-0.5	0.3	1.3
Pulse wave reflection index	1.4	1.7	4.7	-0.3	2.2	-0.5
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	-0.2	0.6	-0.3
Loud music exposure frequency	0.9	0.9	2.5	0.5	-0.3	-1.6
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.1	-0.3	0.4	-0.2
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	2.8	1.2	-1.7	-1.1
Blood clot in the leg (DVT)	0.5	0.7	1.9	-0.4	1.4	-0.1
Medication: Paracetamol	0.3	0.5	0.7	0.8	0.8	-0.6
Headache pain in last month	0.0	0.1	0.2	0.1	0.4	0.2
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	-0.3	0.3	0.4
Glaucoma (self-reported)	0.2	0.2	0.3	-0.4	0.3	0.6
Gout (self-reported)	0.4	0.5	1.5	1.2	-0.2	0.0
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.5	0.8	0.6	1.6
Medication: Amlodipine	0.3	0.4	0.6	-0.4	0.6	0.7
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.6	-0.1	-0.8	0.4
Birth weight	0.5	1.1	2.6	-0.8	1.6	0.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	0.9	-0.7	1.0	0.6
High blood pressure (siblings)	0.6	0.8	2.3	1.5	-0.2	0.4
Forced vital capacity (FVC), Best measure	1.6	5.8	10.1	-3.2	2.6	-0.9
Body fat percentage	0.1	0.3	0.9	-0.1	0.2	-0.9
Leg fat percentage (right)	0.1	0.3	0.6	0.3	-0.4	-0.8
Arm fat-free mass (right)	0.3	1.8	3.1	-1.5	1.8	-0.2
Exposure to tobacco smoke outside home	0.2	0.3	0.9	0.9	-0.3	0.2
Comparative body size at age 10	0.2	0.5	0.8	0.0	0.9	-0.7
Number of full brothers	0.2	0.3	0.4	0.6	-0.2	0.6
Worry too long after embarrassment	0.3	0.5	1.0	-0.2	-1.0	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	2.4	3.1	4.8	-2.1	2.2	-0.5
Wheeze or whistling in the chest in last year	0.6	1.1	1.9	-1.4	1.2	0.1
Number of children fathered	1.5	1.7	2.6	1.4	-1.6	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	-0.8	0.0	-0.2
Age at first live birth	0.3	0.5	1.3	-1.1	0.1	0.4
Pulse wave peak to peak time	0.2	0.3	0.7	-0.8	0.2	0.2
Health satisfaction	1.5	2.0	4.5	2.1	0.3	-1.2
Shortness of breath walking on level ground	0.6	0.7	2.0	0.2	1.4	-0.1
Qualifications: College or University degree	1.1	3.3	6.6	-2.6	1.8	-0.2
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.4	0.2	-0.3
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.7	-0.8	0.9	1.7
Emphysema/chronic bronchitis	0.4	0.5	0.8	-0.8	-0.2	-0.9
Medication for pain relief, constipation, heartburn	0.4	0.6	1.1	-1.0	0.3	0.8
Neck or shoulder pain in last month	0.2	0.3	0.5	0.7	-0.6	-0.1
Medication: Blood pressure	0.1	0.2	0.5	-0.4	-0.2	-0.7
Angina (self-reported)	0.3	0.4	1.2	0.2	-0.1	-1.1
Migraine (self-reported)	1.0	1.3	3.8	-0.2	0.1	-1.9
Medication: Ibuprofen	0.8	1.0	1.9	-1.4	1.0	0.1
Medication: Allopurinol	1.2	1.6	3.2	1.8	-1.1	0.6
Medication: Omeprazole	0.2	0.2	0.7	-0.1	-0.0	-0.8
Medication: Seretide 50 evohaler	0.1	0.1	0.3	0.5	0.2	0.1
Mean time to correctly identify matches	1.7	3.3	4.2	2.0	-1.9	1.4
Heart disease (mother)	0.4	0.5	1.2	0.5	-0.3	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.8	3.3	5.6	2.4	-1.2	1.7
Whole body fat mass	0.2	0.7	1.0	-0.6	0.8	-1.0
Leg fat mass (right)	0.2	0.6	1.0	-0.6	0.6	-1.0
Arm predicted mass (right)	0.4	1.9	3.3	-1.5	1.8	-0.2
Pulse rate, automated reading	0.3	0.9	2.4	0.4	-0.5	1.5
Alcohol intake frequency.	0.2	0.4	0.6	-0.5	0.8	0.6
Comparative height size at age 10	0.2	1.3	3.9	-0.1	2.0	0.1
Number of full sisters	1.1	1.3	2.1	1.5	-0.5	1.2
Suffer from ‘nerves’	1.5	2.4	3.5	-1.9	1.8	0.7
Overall health rating	1.2	2.7	6.2	2.5	-1.3	0.4
Chest pain or discomfort	0.5	0.7	1.8	-0.2	-0.3	1.4
Had major operations	0.4	0.4	1.0	1.0	0.4	-0.3
Age at last live birth	0.1	0.2	0.4	-0.3	-0.6	-0.3
Family relationship satisfaction	0.4	0.4	0.9	1.0	-0.6	0.2
Leg pain on walking	2.3	2.9	8.0	2.8	-0.6	0.6
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	3.4	1.8	0.4	-1.0
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.0	-0.3	0.1	1.0
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.5	-0.7	-0.6	0.0
Medication: Aspirin	0.9	1.2	1.9	1.2	-1.4	-0.7
Supplements: Vitamin C	0.9	1.1	2.8	0.2	-0.7	-1.7
Knee pain experienced in last month	0.3	0.4	0.7	0.8	0.1	0.8
Hypertension (Self-reported)	0.1	0.2	0.6	-0.8	0.3	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.3	-0.0	-0.1	-1.5
Illnesses of father: Heart disease	0.6	0.8	1.2	-0.8	1.1	0.7
Illnesses of siblings: Diabetes	0.2	0.3	0.6	0.4	0.2	-0.8
Smoking status: Previous	1.0	1.6	3.4	1.9	0.1	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	5.2	-2.1	2.3	-1.0
Whole body fat-free mass	0.5	2.6	4.8	-1.7	2.2	-0.1
Leg fat-free mass (right)	0.6	3.2	5.2	-2.1	2.3	-0.3
Arm fat percentage (left)	0.1	0.2	0.7	-0.1	-0.0	-0.8
Average weekly red wine intake	2.1	3.1	6.2	2.5	-1.5	1.0
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.7	0.3	-0.3	0.8
Mood swings	0.3	0.5	1.1	-0.6	0.4	1.0
Loneliness, isolation	2.1	2.8	6.1	-1.5	2.5	0.4
Long-standing illness, disability or infirmity	1.8	2.7	5.2	2.3	-0.5	1.6
Ever had bowel cancer screening	0.3	0.4	1.0	1.0	-0.3	0.2
Diabetes diagnosed by doctor	0.1	0.1	0.3	-0.0	0.5	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.1	1.5	-0.2	0.4
Friendships satisfaction	0.7	0.9	1.4	-0.4	-1.2	-1.0
Qualifications: nursing, teaching	0.4	0.7	1.4	-0.7	1.2	0.3
Commuting to job workplace: Walk	1.3	1.4	2.9	-1.1	0.2	-1.7
Eye problems/disorders: Cataract	0.2	0.3	0.7	0.3	-0.8	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	1.6	1.2	0.2	1.2
Medication for cholesterol	2.6	4.0	6.1	-2.1	1.3	-2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.7	3.5	1.9	-0.4	-1.3
Back pain experienced in last month	0.7	1.1	2.0	1.1	-0.3	1.4
Mineral and other dietary supplements	0.1	0.1	0.2	-0.4	-0.1	-0.1
Breast cancer (self-reported)	1.1	1.3	2.5	-1.6	1.1	0.2
Asthma (self-reported)	0.3	0.6	0.7	-0.6	0.8	-0.8
Osteoporosis (self-reported)	0.2	0.2	0.3	0.5	-0.4	0.4
Osteoarthritis (self-reported)	5.7	7.3	10.8	2.7	-3.3	2.0
Medication: Aspirin	1.0	1.3	1.9	1.3	-1.4	-0.6
Medication: Gliclazide	0.0	0.0	0.0	-0.1	-0.2	-0.1
Illnesses of father: None of the above (group 1)	0.5	0.7	1.7	-0.4	-0.3	-1.3
Smoking status: Current	0.5	0.8	1.7	-0.8	-1.3	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.2	-0.1	-0.1	-0.5
Whole body water mass	0.4	2.5	4.5	-1.7	2.1	-0.2
Leg predicted mass (right)	0.6	3.3	5.3	-2.1	2.3	-0.3
Arm fat mass (left)	0.1	0.3	0.5	-0.4	0.4	-0.7
Number of self-reported non-cancer illnesses	1.2	2.1	5.2	2.3	0.0	1.1
Average weekly champagne plus white wine intake	0.1	0.2	0.6	-0.0	-0.8	0.1
Miserableness	1.1	2.0	4.8	-0.5	2.2	0.9
Guilty feelings	0.5	0.8	1.5	0.2	-1.2	0.9
Wears glasses or contact lenses	0.6	0.7	1.4	1.2	-0.5	-0.6
Ever taken oral contraceptive pill	0.1	0.1	0.1	-0.2	-0.2	-0.3
Hearing aid user	0.5	0.6	0.9	0.9	0.0	-0.9
Mother’s age at death	1.1	1.4	4.1	-2.0	-0.0	-0.2
Financial situation satisfaction	1.7	2.1	4.5	2.1	-1.3	0.1
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.9	-0.4	0.9	-1.4
Commuting to job workplace: Public transport	0.3	0.3	0.7	0.8	0.4	-0.3
Eye problems/disorders: Glaucoma	1.0	1.2	2.3	-1.1	1.5	0.2
Medication: Blood pressure	0.3	0.6	0.6	-0.8	-0.7	0.8
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.8	1.7	-0.7	0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.3	0.0	1.1	-0.1
High cholesterol (Self-reported)	2.6	4.6	6.0	2.5	-2.4	1.5
Medication: Bendroflumethiazide	0.8	1.2	1.8	-1.1	0.9	-1.3
Medication: Paracetamol	0.2	0.4	0.8	0.4	0.9	-0.4
Medication: Lisinopril	0.3	0.4	1.3	-1.1	-0.0	0.3
Medication: Atorvastatin	0.3	0.3	0.9	1.0	0.3	-0.2
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.2	0.2	0.5
Alcohol drinker status: Never	0.3	0.3	0.9	-0.9	0.4	-0.0
Ever smoked	0.4	0.6	1.4	1.2	-0.6	-0.3
Basal metabolic rate	0.4	2.3	4.2	-1.6	2.0	-0.4
Leg fat percentage (left)	0.1	0.2	0.3	0.1	-0.5	-0.5
Arm fat-free mass (left)	0.3	1.5	2.8	-1.3	1.7	0.0
Number of operations (self-reported)	1.1	1.6	3.0	1.7	-0.5	1.3
Average weekly beer plus cider intake	0.3	0.5	0.8	0.1	0.9	-0.8
Irritability	0.4	0.6	1.1	1.1	-0.8	0.3
Risk taking	0.6	0.9	2.5	-1.6	0.3	-0.4
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.5	0.3	0.7	0.5
Fractured/broken bones in last 5 years	0.1	0.1	0.3	-0.2	0.3	0.5
Age started oral contraceptive pill	0.3	0.3	0.6	-0.2	0.8	0.6
Diastolic blood pressure, automated reading	0.1	0.4	0.8	0.9	-0.6	-0.2
Ever depressed for a whole week	1.0	1.2	1.7	1.3	-0.9	1.0
Unable to work because of sickness or disability	0.7	0.9	1.5	0.5	-1.0	1.2
Commuting to job workplace: Cycle	2.8	3.4	7.1	-1.1	2.7	-1.4
Myopia	0.8	1.2	2.1	-0.9	1.4	-0.8
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.1	0.3	-0.4	0.3
Cholesterol lowering medication	1.1	1.6	3.3	1.8	-0.7	1.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	-0.1	-0.3	-0.5
Pain experienced in last month	0.7	1.2	2.8	-1.7	0.3	-0.8
Supplements: Calcium	2.1	2.3	6.0	0.9	-0.1	2.4
Basal cell carcinoma (self-reported)	1.5	1.8	1.9	1.3	-1.4	1.3
Heart attack/myocardial infarction (self-reported)	1.6	2.0	4.7	2.2	-0.9	0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.7	0.1	1.3	-0.0
Heart disease (siblings)	1.3	1.6	2.2	1.5	-1.3	1.0
Alcohol drinker status: Previous	0.2	0.2	0.3	-0.6	0.5	-0.3
Pack years of smoking	0.5	0.7	1.3	-0.8	1.1	0.6
Impedance of whole body	0.2	1.0	2.0	1.4	-1.0	0.2
Leg fat mass (left)	0.1	0.4	0.5	-0.6	0.5	-0.7
Arm predicted mass (left)	0.3	1.6	3.2	-1.2	1.8	-0.0