TWAS
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Traits
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Forced vital capacity (FVC)
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chr2:55,079,242-56,843,605
Best TWAS P=4.84e-53 · Best GWAS P=3.1e-69 conditioned to 1.5e-09
55M
55.2M
55.4M
55.6M
55.8M
56M
56.2M
56.4M
56.6M
56.8M
0
20
40
60
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Brain Frontal Cortex BA9
EFEMP1
0.19
0.10
lasso
8
0.08
3.7e-03
-15.32
-15.3
4.8e-53
0.78
0.04
0.70
TRUE
2
GTEx
Cells Transformed fibroblasts
EFEMP1
0.11
0.00
enet
22
0.05
1.1e-04
-0.50
-6.9
4.1e-12
0.39
0.16
0.57
TRUE
5
The Cancer Genome Atlas
Breast Invasive Carcinoma
EFEMP1
0.02
0.01
blup
79
0.02
3.9e-05
-17.59
11.9
1.0e-32
-0.73
0.00
1.00
FALSE
3
ROSMAP
Brain Pre-frontal Cortex
EFEMP1
0.29
0.14
enet
37
0.19
2.2e-24
-10.36
-9.9
3.2e-23
0.64
1.00
0.00
FALSE
4
YFS
Blood
SMEK2
0.07
0.04
enet
34
0.05
7.1e-17
0.95
5.1
2.8e-07
-0.24
1.00
0.00
FALSE