Best TWAS P=4.84e-53 · Best GWAS P=3.1e-69 conditioned to 1.5e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Frontal Cortex BA9 | EFEMP1 | 0.19 | 0.10 | lasso | 8 | 0.08 | 3.7e-03 | -15.32 | -15.3 | 4.8e-53 | 0.78 | 0.04 | 0.70 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | EFEMP1 | 0.11 | 0.00 | enet | 22 | 0.05 | 1.1e-04 | -0.50 | -6.9 | 4.1e-12 | 0.39 | 0.16 | 0.57 | TRUE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | EFEMP1 | 0.29 | 0.14 | enet | 37 | 0.19 | 2.2e-24 | -10.36 | -9.9 | 3.2e-23 | 0.64 | 1.00 | 0.00 | FALSE |
| 4 | YFS | Blood | SMEK2 | 0.07 | 0.04 | enet | 34 | 0.05 | 7.1e-17 | 0.95 | 5.1 | 2.8e-07 | -0.24 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EFEMP1 | 0.02 | 0.01 | blup | 79 | 0.02 | 3.9e-05 | -17.59 | 11.9 | 1.0e-32 | -0.73 | 0.00 | 1.00 | FALSE |