TWAS hub - SMEK2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1060	0.0350	3.5e-04	0.064	NA	0.092	NA	0.104	1.5e-05	NA	2.1e-07	NA	3.5e-08
2	GTEx	Esophagus Mucosa	0.0970	0.0420	7.6e-03	-0.003	NA	-0.004	NA	-0.003	6.6e-01	NA	8.8e-01	NA	5.6e-01
3	GTEx	Skin Sun Exposed Lower leg	0.0850	0.0350	1.9e-03	0.086	NA	0.063	NA	0.079	1.3e-07	NA	5.7e-06	NA	4.7e-07
4	GTEx	Stomach	0.1410	0.0480	8.8e-04	0.018	NA	0.043	NA	0.012	4.6e-02	NA	3.9e-03	NA	7.9e-02
5	GTEx	Thyroid	0.1270	0.0410	5.0e-05	0.085	NA	0.060	NA	0.068	4.5e-07	NA	2.3e-05	NA	6.9e-06
6	METSIM	Adipose	0.0537	0.0183	2.1e-05	0.046	0.040	0.041	0.039	0.034	1.9e-07	1.2e-06	7.9e-07	1.6e-06	5.7e-06
7	ROSMAP	Brain Pre-frontal Cortex	0.0651	0.0264	3.6e-03	0.047	0.026	0.026	0.032	0.040	9.1e-07	2.5e-04	2.4e-04	5.4e-05	6.3e-06
8	YFS	Blood	0.0691	0.0172	1.4e-12	0.043	0.046	0.053	0.052	0.052	6.4e-14	5.8e-15	7.1e-17	1.5e-16	1.2e-16
9	TCGA	Head and Neck Squamous Cell Carcinoma	0.0621	0.0369	8.8e-04	0.018	0.029	0.021	NA	0.017	3.6e-03	3.0e-04	1.6e-03	NA	4.6e-03
10	TCGA	Prostate Adenocarcinoma	0.0429	0.0229	8.3e-04	0.029	0.028	0.030	NA	0.034	4.6e-04	5.4e-04	3.8e-04	NA	1.6e-04
11	TCGA	Stomach Adenocarcinoma	0.0620	0.0350	6.5e-03	-0.004	0.009	0.004	NA	0.001	8.2e-01	6.3e-02	1.5e-01	NA	2.4e-01
12	TCGA	Thyroid Carcinoma	0.1420	0.0770	2.0e-05	0.054	0.040	0.048	NA	0.048	5.0e-06	8.6e-05	1.9e-05	NA	1.8e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Ever highly irritable/argumentative for 2 days	4.8	5.8	19.3	-2.8	-2.4	-0.6	-1.1	-1.2	-2.4	-0.9	-2.5	-4.4	-3.2	-2.5	-2.2
Eye problems/disorders: Diabetes related eye disease	3.7	4.1	6.9	2.5	1.6	2.4	1.9	2.6	0.9	1.0	1.3	2.0	2.0	2.6	2.3
Serious illness, injury or assault to yourself	3.3	4.0	7.9	2.2	-0.1	1.4	1.6	2.4	2.6	0.1	2.8	1.7	2.7	1.4	2.4
Qualifications: O levels/GCSEs or equivalent	3.0	4.8	8.3	2.5	0.9	1.6	-0.2	2.5	1.8	2.1	2.3	2.9	2.5	2.8	2.6
Shortness of breath walking on level ground	3.0	3.6	6.4	-1.8	-1.9	-1.0	-1.9	-1.5	-2.0	0.4	-2.1	-2.5	-2.5	-2.0	-1.9
Commuting to job workplace: Car/motor vehicle	2.7	3.1	14.7	0.7	0.6	1.1	1.1	1.6	1.1	3.8	1.3	1.4	0.6	2.7	1.9
Mouth/teeth dental problems: Mouth ulcers	2.6	4.1	9.9	-1.8	-3.1	-2.3	-2.3	-2.1	0.1	-1.1	-1.2	-2.8	-1.6	-2.1	-1.7
Coronary Artery Disease (CAD)	2.5	3.0	7.5	2.1	2.2	0.6	2.7	1.5	1.0	0.0	1.8	2.1	2.7	0.8	0.3
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.6	5.6	-0.8	-1.5	-1.8	-1.4	-2.4	-0.6	-1.4	-2.1	-2.1	-1.4	-1.8	-1.4
Past tobacco smoking	2.3	4.2	7.7	2.7	0.5	1.4	1.5	2.4	1.7	1.6	2.1	2.8	2.0	2.1	2.6
Allergy	2.2	5.2	13.2	-2.6	-0.6	1.7	0.8	0.9	-3.0	-3.6	-1.9	-3.1	-2.2	-2.7	-1.7
LDL Cholesterol	2.1	3.2	5.5	1.4	1.5	1.5	1.6	2.4	1.6	1.4	1.6	2.1	2.2	2.0	2.0
Neuroticism (2016)	2.1	3.0	5.4	-1.6	-1.1	-1.0	-0.7	-1.8	-1.9	-0.9	-1.6	-2.1	-2.3	-2.3	-2.2
Leg pain on walking	2.1	2.6	10.6	-1.7	-2.8	-1.0	-3.3	-1.2	0.7	1.1	-0.9	-0.9	-1.5	0.2	-1.2
Mood swings	2.1	3.8	8.3	-2.3	-0.9	-0.7	-1.2	-1.6	-1.6	-1.7	-1.8	-2.5	-2.3	-2.6	-2.9
Eye problems/disorders: Cataract	2.1	2.5	4.4	1.9	0.9	1.7	1.2	1.8	0.8	1.4	1.2	1.8	1.4	1.9	2.1
Crohns Disease (2012)	2.0	3.2	6.8	0.8	0.8	0.9	0.3	1.6	2.5	2.2	2.6	1.8	1.9	2.2	1.9
Hayfever, allergic rhinitis or eczema	2.0	4.4	14.4	2.1	-0.2	-1.4	-0.7	-0.7	2.9	3.8	1.2	3.2	1.5	2.6	1.6
Breastfed as a baby	2.0	2.5	6.6	2.3	0.5	0.2	0.4	0.6	1.8	2.3	1.1	1.3	1.1	2.6	2.2
Risk taking	2.0	2.9	8.2	-2.0	-0.5	0.1	-1.9	-0.7	-1.8	-1.0	-1.6	-2.9	-2.2	-1.2	-2.3
Ulcerative Colitis	1.9	2.8	6.0	1.7	-0.0	-0.4	-1.2	0.8	2.4	1.4	2.2	1.8	1.8	2.4	1.9
Impedance of arm (left)	1.9	8.9	24.8	2.1	3.5	5.0	1.5	5.0	2.3	-1.7	4.5	0.6	2.2	1.1	1.8
Age at first live birth	1.9	3.4	7.5	2.7	1.0	0.1	0.2	0.9	2.3	0.9	2.3	2.1	2.6	2.0	2.2
Prostate Cancer	1.8	2.5	5.1	-1.9	-1.6	-0.1	-0.9	-0.3	-1.5	-1.8	-1.0	-2.1	-1.5	-2.2	-2.2
Smoking Status	1.8	4.4	10.6	-2.3	0.1	-0.3	-1.1	-1.3	-3.1	-1.2	-2.8	-3.3	-2.3	-2.0	-2.4
Townsend deprivation index at recruitment	1.8	2.6	5.8	-2.2	-0.6	-0.4	-0.7	-1.0	-2.3	-1.0	-1.9	-1.5	-1.6	-1.8	-2.4
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	6.8	-1.8	-1.7	-0.7	-0.8	-1.2	-0.8	1.5	-2.0	-1.7	-2.6	-0.7	-1.0
Impedance of arm (right)	1.8	8.3	22.5	2.3	3.3	4.7	1.2	4.7	2.7	-1.5	4.2	0.3	2.4	1.0	2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.7	5.7	-2.2	-1.4	-0.6	-2.0	-1.2	-0.3	-0.4	-2.4	-2.3	-2.3	-1.4	-1.2
Medication: Blood pressure	1.8	3.2	9.3	-2.4	0.5	0.3	-0.0	-0.7	-3.1	0.3	-2.5	-1.8	-2.4	-1.5	-2.2
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	6.7	-0.7	-2.6	-2.4	-2.0	-1.8	1.4	1.1	1.1	1.1	0.0	0.6	-0.6
Eye problems/disorders: None of the above	1.7	2.0	6.6	-1.7	-1.2	-1.8	-2.6	-1.5	0.3	-0.5	-0.1	-1.6	-0.9	-0.9	-1.7
Comparative height size at age 10	1.7	9.3	31.2	-2.2	-3.6	1.7	-5.6	2.0	2.7	-3.5	4.1	-3.3	-1.5	-0.8	-2.3
Ulcerative Colitis (UC)	1.6	3.0	7.6	1.9	1.7	0.9	0.2	1.8	1.3	0.1	2.8	1.3	2.2	1.9	2.3
Height	1.6	30.5	104.0	-3.4	-4.5	6.3	-8.4	6.2	3.7	-5.5	10.2	-4.8	-1.8	-0.5	-3.1
Hypothyroidism (self reported)	1.6	3.7	13.1	-2.3	-1.4	-0.2	-0.8	-1.3	-1.9	0.3	-1.8	-3.6	-2.8	-1.2	-2.3
Severe depression (siblings)	1.6	1.8	6.8	-1.6	-0.7	-1.4	-2.6	-1.1	1.3	1.7	-1.0	-0.7	-1.3	0.3	-0.6
Medication: Atorvastatin	1.6	1.9	3.3	1.2	1.4	1.1	1.8	1.7	0.4	1.2	1.3	1.6	1.6	1.5	1.4
Age at First Birth	1.5	2.1	5.4	0.8	-0.6	0.3	-0.6	1.2	2.2	1.9	2.3	1.8	1.4	2.0	0.4
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	3.6	-1.4	0.5	-0.6	-0.5	-1.2	-0.8	-1.1	-1.6	-1.9	-1.4	-1.8	-1.4
Pulse rate	1.5	2.5	4.7	1.3	1.8	1.5	1.8	2.0	1.3	-0.4	1.5	2.1	2.2	0.7	1.4
Depression (self-reported)	1.5	1.8	7.5	-1.2	-0.4	-1.5	0.3	-1.8	0.0	-0.2	-2.7	-0.8	-0.9	-2.0	-1.3
Standing height	1.5	15.2	49.8	-3.2	-4.1	2.9	-7.1	3.1	3.6	-3.1	6.8	-2.9	-1.3	0.0	-2.7
Birth weight of first child	1.5	2.8	14.4	-1.2	-3.8	-1.4	-2.3	-0.9	1.8	1.3	0.9	-1.4	-0.8	0.9	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	5.6	0.5	1.8	2.4	1.7	2.4	-0.4	0.7	0.5	0.7	0.2	1.1	1.3
Average weekly spirits intake	1.4	1.8	4.7	-1.1	0.9	2.2	1.4	1.8	-1.8	-1.3	-0.5	-1.6	-0.7	-1.0	-0.6
Systolic blood pressure, automated reading	1.4	4.1	24.6	0.7	0.8	-0.5	1.2	-0.7	-2.3	5.0	-0.7	2.7	-0.5	2.8	0.2
Supplements: Zinc	1.4	1.5	4.6	-1.8	-2.1	-0.7	-0.9	-0.8	-0.5	-1.3	-0.9	-0.8	-1.3	-1.3	-1.2
Forced vital capacity (FVC)	1.4	5.4	26.4	-1.0	-0.4	2.4	-3.0	2.2	3.3	-1.8	5.1	-0.2	0.4	-0.2	-1.7
Neuroticism score	1.4	3.0	7.3	-1.7	-0.7	-1.0	-1.0	-1.7	-1.1	-1.4	-2.2	-1.9	-2.2	-2.7	-2.0
Tense / ‘highly strung’	1.4	2.4	4.6	-1.7	-1.1	-2.0	-1.1	-2.2	0.1	-0.1	-2.1	-0.7	-1.7	-1.7	-1.9
Pulse wave reflection index	1.4	1.7	6.1	-1.8	-0.6	0.7	-0.2	-0.0	-2.5	0.2	-1.0	-2.0	-2.2	-0.4	-0.6
Forced vital capacity (FVC), Best measure	1.4	5.1	22.8	-1.4	-1.1	1.6	-3.4	1.6	3.3	-2.2	4.8	-0.4	0.2	-0.6	-1.4
Age at last live birth	1.4	2.1	4.2	1.8	1.1	1.0	0.1	1.4	0.8	0.1	2.1	1.7	2.1	1.7	1.6
Ever taken oral contraceptive pill	1.4	1.6	6.4	-0.4	0.6	1.1	-0.1	0.7	-2.5	-0.9	-0.4	-2.5	-1.1	-1.2	-0.7
Eye problems/disorders: Glaucoma	1.4	1.7	3.7	-0.3	0.6	1.5	1.6	1.3	-1.6	-1.6	-1.8	-1.0	-0.7	-1.9	0.1
Irritability	1.4	2.4	5.0	-2.1	0.2	-0.5	0.2	-1.4	-1.8	-0.1	-2.0	-1.6	-2.2	-1.7	-2.1
Ever depressed for a whole week	1.4	1.7	5.0	-2.2	-2.1	-0.3	-0.7	-0.5	0.1	0.6	-1.3	-1.7	-2.2	-0.6	-0.4
Alzheimer’s Disease (in father)	1.3	1.4	5.3	-1.1	0.9	-0.3	-0.2	-0.9	-0.4	-2.0	-1.1	-1.6	-0.6	-2.3	-0.8
Allergy or Eczema	1.3	3.3	10.9	2.1	0.2	-1.6	-0.5	-1.2	2.3	3.3	0.9	2.6	1.4	2.1	1.2
Multivitamins +/- minerals	1.3	1.6	3.4	-1.3	-1.5	-1.3	-0.4	-1.5	-0.5	-1.8	-0.8	-1.3	-1.0	-1.8	-1.3
Alcohol usually taken with meals	1.3	2.1	4.9	-1.8	-2.2	-0.4	-1.5	-0.5	-1.0	-0.3	-0.8	-1.4	-2.0	-1.7	-2.1
Trunk fat-free mass	1.3	7.3	31.1	-3.4	-4.5	-1.5	-5.6	-1.3	1.2	-0.5	1.4	-2.2	-2.1	-0.5	-2.7
Trunk predicted mass	1.3	7.3	31.8	-3.4	-4.4	-1.5	-5.6	-1.3	1.2	-0.5	1.5	-2.1	-2.1	-0.5	-2.7
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	10.1	-1.8	-0.5	-0.1	-0.1	-1.1	-1.8	-0.6	-0.7	-3.2	-1.9	-1.3	-2.3
Medication: Amlodipine	1.3	1.8	4.7	-1.8	-1.1	0.3	-0.8	-0.1	-1.9	-0.6	-1.6	-1.4	-2.2	-1.2	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	6.8	0.1	-0.5	1.4	-0.1	1.6	-0.9	1.5	2.6	0.8	0.2	1.6	-0.0
Ever smoked	1.3	2.3	5.4	-2.3	0.1	-0.7	-0.7	-1.6	-1.6	-1.2	-1.2	-2.1	-1.6	-1.5	-2.0
Impedance of whole body	1.3	6.4	19.5	1.6	3.6	4.4	2.0	4.1	0.9	-2.2	3.5	-0.2	1.6	0.0	0.8
Ever used hormone-replacement therapy (HRT)	1.2	1.5	4.3	-1.2	0.1	-1.4	-1.1	-2.1	-0.8	0.1	-1.0	-1.3	-1.3	-0.8	-1.8
Diabetes (mother)	1.2	1.5	6.8	-0.6	0.4	1.7	-0.1	1.0	-2.6	0.2	-1.4	-1.4	-1.6	-0.2	-0.5
Suffer from ‘nerves’	1.2	1.8	4.3	-1.1	-1.2	-1.9	-1.4	-2.1	0.9	-0.8	-1.1	-0.4	-0.8	-1.5	-1.9
Whole body fat-free mass	1.2	6.7	30.7	-3.3	-4.3	-1.4	-5.5	-1.1	1.4	-0.4	1.4	-1.8	-1.9	-0.3	-2.5
Whole body water mass	1.2	7.0	31.2	-3.4	-4.4	-1.5	-5.6	-1.2	1.3	-0.4	1.3	-1.9	-2.0	-0.4	-2.6
Guilty feelings	1.2	1.8	4.1	-1.8	-1.7	1.3	-0.4	1.0	-0.8	-1.1	-1.1	-1.9	-2.0	-1.6	-0.4
Arm fat-free mass (left)	1.2	6.2	24.1	-3.4	-4.0	-1.6	-4.9	-1.4	0.5	-0.4	0.8	-1.9	-2.1	-0.8	-2.9
Ever had prostate specific antigen (PSA) test	1.2	1.4	4.2	-2.1	-1.7	0.0	-1.4	-0.6	-1.3	-0.2	-0.5	-0.5	-1.8	-0.1	-1.3
Triglycerides	1.1	1.7	3.4	1.5	1.6	0.6	1.0	1.2	1.7	0.3	0.4	1.8	1.8	0.9	1.6
Blood Platelet Count	1.1	12.5	21.9	4.5	4.7	2.6	4.1	3.1	1.8	-0.7	3.3	3.3	4.7	2.4	4.6
Neuroticism	1.1	2.7	6.1	-1.5	-1.1	-0.5	-0.6	-1.3	-1.6	-0.7	-2.3	-2.1	-2.5	-2.2	-1.7
Sensitivity / hurt feelings	1.1	2.0	4.9	-1.6	0.3	-0.1	0.0	-0.9	-0.9	-1.2	-0.9	-2.2	-1.8	-2.2	-2.0
Qualifications: CSEs or equivalent	1.1	1.5	7.0	-0.9	0.5	-1.0	-2.6	-0.8	0.8	2.2	0.0	1.4	-0.1	0.5	-0.7
Medication: Levothyroxine sodium	1.1	1.8	7.0	-0.9	0.5	1.1	1.2	0.2	-2.2	-1.2	-0.2	-2.6	-1.3	-1.0	-1.3
Nervous feelings	1.1	2.1	5.6	-1.4	-0.4	-0.9	-0.7	-1.2	-1.1	-0.9	-2.4	-1.1	-1.7	-1.9	-2.2
Happiness	1.1	1.4	3.9	-1.1	-0.9	-0.6	0.6	-0.8	-0.6	-1.7	-0.9	-2.0	-0.7	-1.8	-1.1
Prospective memory result	1.1	1.3	4.9	-0.7	-1.4	-2.2	-1.5	-1.6	1.7	0.8	-0.3	0.6	-0.3	-0.3	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	10.6	-1.1	-1.2	1.1	-3.2	1.4	2.9	-1.9	3.2	-0.5	0.1	-0.8	-1.0
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.5	1.3	0.1	-0.2	0.5	0.5	1.5	1.3	1.9	1.1	1.4	1.2	1.1
Arm fat-free mass (right)	1.1	5.8	22.3	-3.5	-4.0	-1.5	-4.7	-1.2	0.6	-0.1	0.9	-1.4	-2.1	-0.4	-2.7
Exposure to tobacco smoke outside home	1.1	1.5	4.8	-2.2	-1.3	-0.3	-1.1	-0.9	-0.7	-0.0	-1.1	-1.1	-1.8	-0.8	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	5.2	1.1	1.2	2.3	0.6	2.1	-0.4	0.1	0.4	0.0	0.2	1.3	0.9
Leg fat-free mass (right)	1.1	5.6	27.5	-2.9	-4.1	-1.2	-5.2	-0.7	1.8	-0.5	1.2	-1.5	-1.4	-0.2	-2.0
Leg predicted mass (right)	1.1	5.8	28.1	-2.9	-4.1	-1.3	-5.3	-0.8	1.7	-0.6	1.2	-1.7	-1.5	-0.3	-2.0
Basal metabolic rate	1.1	6.3	28.6	-3.3	-4.0	-1.2	-5.3	-0.9	1.3	-0.4	1.3	-1.9	-1.9	-0.4	-2.5
Arm predicted mass (left)	1.1	5.4	21.7	-3.2	-3.7	-1.5	-4.7	-1.3	0.5	-0.4	0.7	-1.6	-1.9	-0.7	-2.8
Bipolar Disorder (2018)	1.0	1.5	4.4	0.2	1.0	-0.1	-0.2	0.4	1.6	2.1	1.3	1.9	0.8	1.8	0.9
Impedance of leg (right)	1.0	5.0	16.7	1.3	4.1	3.8	2.5	3.1	0.0	-1.3	2.7	0.1	1.2	0.1	0.3
Supplements: Glucosamine	1.0	1.3	5.9	0.9	-0.4	-0.2	0.3	0.1	2.4	1.1	1.6	1.4	1.0	1.3	0.5
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	5.1	-0.4	0.1	2.3	1.2	2.1	-0.3	-0.2	0.7	-1.1	-0.4	0.4	0.4
Heart attack	1.0	1.2	4.5	0.4	0.6	2.1	-0.1	2.1	0.7	0.8	0.6	-0.1	0.2	1.4	1.4
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	11.0	-1.0	-0.9	1.4	-3.1	1.3	2.8	-1.7	3.3	-0.6	-0.0	-0.7	-1.5
Arm predicted mass (right)	1.0	5.2	20.2	-3.2	-3.7	-1.7	-4.5	-1.3	0.8	0.0	1.3	-1.1	-1.7	-0.4	-2.7
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.2	6.2	-0.8	-2.2	0.6	-2.5	1.1	1.9	-1.1	2.4	-1.2	0.1	0.4	-0.1
Alcohol drinker status: Never	1.0	1.2	6.0	-0.8	-0.4	-0.5	-2.4	-0.5	1.2	1.0	1.1	1.2	-0.5	0.3	-1.2
Commuting to job workplace: Cycle	1.0	1.2	4.4	-0.5	-0.1	2.0	-0.8	1.9	-0.2	-0.0	2.1	0.3	-0.2	1.0	-0.2
Systolic Blood Pressure	0.9	4.3	26.5	-0.3	0.7	-0.5	0.0	-1.2	-3.2	5.2	-1.2	2.1	-1.4	1.9	-0.9
Vitamin and mineral supplements	0.9	1.2	4.4	1.0	1.3	0.6	-0.1	0.9	0.8	2.1	0.5	1.1	0.9	1.5	1.1
Qualifications: A levels/AS levels or equivalent	0.9	1.9	6.3	0.3	-0.4	0.2	-1.0	0.9	2.0	1.9	1.4	1.8	0.9	2.5	0.6
Mouth/teeth dental problems: Dentures	0.9	1.4	3.5	1.1	1.5	1.8	1.1	1.8	0.6	-0.4	1.9	0.4	1.1	0.6	0.7
High blood pressure (siblings)	0.9	1.4	8.4	0.4	0.4	0.2	-0.0	0.3	0.2	2.9	0.5	2.4	0.6	1.1	0.3
Comparative body size at age 10	0.9	2.4	7.9	-0.6	-0.8	-2.8	0.6	-2.8	-0.4	-1.0	-2.6	-1.1	-0.5	-1.5	0.2
Migraine (self-reported)	0.9	1.1	6.4	-0.2	-1.1	-1.5	-1.3	-1.0	2.5	0.6	-0.2	0.4	-0.1	0.0	-0.0
Medication: Allopurinol	0.9	1.2	2.7	-1.0	-1.3	-1.3	-1.4	-1.6	0.5	0.5	-1.3	-1.0	-1.3	-0.2	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.9	0.1	1.3	0.5	1.1	0.7	1.4	1.1	0.0	1.7	1.1	0.9	1.0
Supplements: Vitamin C	0.9	1.1	3.1	1.2	0.2	1.6	0.6	1.8	-0.2	0.3	1.4	0.6	0.5	1.3	1.2
Average weekly red wine intake	0.9	1.4	3.4	-1.5	-1.8	-1.5	-1.1	-1.5	0.3	1.2	-0.3	-0.8	-1.4	-0.1	-0.8
Medication: Gliclazide	0.9	1.0	2.8	-1.0	-1.1	-0.1	-1.1	-0.2	-1.0	-0.1	-1.6	-1.7	-1.2	-0.6	-0.9
Smoking status: Current	0.9	1.5	5.5	-0.7	-0.3	0.1	0.6	-0.1	-2.2	-1.0	-2.3	-1.4	-0.9	-1.4	-0.6
Illnesses of father: High blood pressure	0.9	1.1	6.6	-0.0	1.5	0.9	2.6	0.5	-1.0	1.1	0.3	0.1	0.4	0.4	0.5
Diastolic blood pressure, automated reading	0.9	2.9	10.2	-0.8	1.0	2.7	0.6	1.7	-2.2	3.2	1.5	1.0	-0.9	1.6	-1.0
Myopia	0.9	1.3	4.8	-0.9	0.6	2.2	0.3	1.8	1.2	-0.2	1.8	0.5	0.1	-0.2	-0.9
Alcohol drinker status: Previous	0.9	1.1	3.1	-0.4	0.4	1.4	-0.9	1.1	0.4	1.3	1.6	0.9	-0.1	1.8	0.3
Irritable Bowel Disease (IBD)	0.8	2.0	4.7	1.1	1.5	0.9	0.6	1.4	1.3	0.9	2.2	1.2	1.9	1.7	1.6
Ovarian Cancer	0.8	1.1	3.2	1.2	0.4	1.0	0.3	1.3	0.8	-0.3	1.8	-0.3	1.0	0.9	1.8
Lupus	0.8	1.2	4.9	-0.0	-1.6	-0.8	-1.7	-0.4	0.8	2.2	0.5	0.3	0.2	1.6	0.2
Pack years adult smoking proportion	0.8	1.2	4.5	0.2	1.8	1.4	2.1	1.7	-0.4	0.1	0.3	0.5	0.6	0.5	1.0
Leg fat-free mass (left)	0.8	4.5	23.7	-2.5	-3.3	-0.8	-4.9	-0.4	2.1	0.0	1.9	-0.9	-0.9	0.4	-1.6
Average weekly fortified wine intake	0.8	0.9	2.4	-1.2	-1.4	-0.2	-0.6	-0.6	-1.3	-0.3	-0.7	-1.1	-1.6	-0.8	-0.8
Sitting height	0.8	5.6	23.0	-0.2	-0.8	3.8	-2.6	4.0	2.0	-1.0	4.8	-0.4	0.3	1.3	-0.4
Leg predicted mass (left)	0.8	4.3	22.8	-2.4	-3.2	-0.8	-4.8	-0.3	2.2	-0.0	1.9	-0.9	-0.8	0.5	-1.5
Hair/balding pattern: Pattern 3	0.8	1.2	3.2	0.9	-1.0	-1.0	-1.6	-0.7	1.5	1.8	-0.2	1.1	0.3	1.1	0.4
Illnesses of mother	0.8	1.0	2.8	0.8	0.6	-0.6	-1.1	0.0	1.7	-1.1	0.8	1.5	1.4	-0.2	0.3
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.1	1.5	-0.4	-0.5	-0.7	0.2	1.7	-0.5	1.5	1.4	1.5	0.6	1.5
Glaucoma (self-reported)	0.8	0.9	2.2	0.3	0.7	1.5	1.4	1.5	-0.9	-0.9	-1.1	-0.1	0.1	-1.0	0.6
Medication: Ventolin 100micrograms inhaler	0.8	1.1	5.3	0.7	-0.7	-2.3	-0.6	-1.9	0.3	0.5	-1.3	-0.2	0.0	-0.6	-0.3
Pulse rate, automated reading	0.8	2.4	6.8	1.9	2.2	0.5	2.4	0.5	1.3	-0.1	1.7	1.6	2.6	0.9	0.4
Alcohol intake frequency.	0.8	1.9	4.8	0.8	-0.3	-0.4	-2.0	0.5	2.2	2.0	1.4	1.6	0.8	1.6	0.8
Long-standing illness, disability or infirmity	0.8	1.2	3.8	-0.4	-0.5	2.0	-0.6	1.4	-0.2	1.9	0.6	-0.9	-1.2	1.2	-0.1
Back pain experienced in last month	0.8	1.1	3.8	0.5	-1.3	-0.7	-0.3	-0.4	1.9	1.9	0.8	1.1	0.4	0.9	0.7
Medication: Lisinopril	0.8	1.1	5.2	1.1	1.5	0.7	2.3	0.7	-0.7	-0.0	-0.1	0.3	1.1	-0.1	1.1
Unable to work because of sickness or disability	0.8	1.1	6.6	0.8	-0.1	0.0	-0.8	0.3	2.6	1.3	0.8	0.7	0.6	1.3	0.6
Pain experienced in last month	0.8	1.4	5.5	-0.2	1.3	0.3	2.0	0.2	-1.2	-2.4	-1.4	-0.4	0.3	-1.4	-0.4
Basal cell carcinoma (self-reported)	0.8	1.0	2.1	0.5	1.1	0.3	-0.3	0.9	1.4	1.4	1.2	0.8	1.4	0.8	0.9
Heart attack/myocardial infarction (self-reported)	0.8	1.0	4.0	0.3	0.3	1.9	-0.1	2.0	0.7	0.6	0.5	-0.1	0.2	1.2	1.3
Pack years of smoking	0.8	1.2	4.0	0.3	1.7	1.4	2.0	1.6	-0.1	0.6	0.6	0.6	0.5	0.8	1.1
Alzheimer’s Disease (in mother)	0.7	0.8	2.7	-0.9	-1.2	0.3	0.6	-0.2	-0.2	-0.9	-1.6	-1.3	-1.2	-0.7	-0.3
Reaction Time	0.7	1.3	4.0	-0.9	-2.0	-1.5	-0.4	-1.2	0.6	-1.2	-0.0	-0.9	-0.8	-1.5	-0.8
Rheumatoid Arthritis	0.7	0.9	3.1	0.4	1.8	-0.0	0.7	0.2	-0.2	-1.5	0.6	0.6	1.1	-1.5	-0.8
Blood White Count	0.7	4.9	13.1	2.6	2.7	2.1	3.6	2.7	0.2	-0.0	0.6	2.2	2.5	0.6	2.8
Diabetes (father)	0.7	0.8	2.2	-0.2	0.5	1.2	0.4	1.5	0.8	1.1	1.2	1.0	0.5	1.2	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	3.9	-2.0	-0.5	-0.7	-0.2	-0.9	-0.6	0.5	-1.1	-0.7	-1.4	-1.0	-0.6
Stomach or abdominal pain in last month	0.7	0.8	2.2	0.7	1.5	0.3	1.5	0.2	0.6	-0.4	1.3	0.9	1.2	-0.5	0.4
High blood pressure (mother)	0.7	0.9	3.2	-0.7	-1.3	0.6	-0.1	0.0	-1.4	1.8	-0.7	-0.6	-1.3	0.8	-0.3
Impedance of leg (left)	0.7	3.4	9.7	0.5	3.1	3.1	2.0	2.4	-0.9	-2.4	1.5	-1.1	0.2	-1.3	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.9	-0.8	-0.8	-2.0	0.1	-1.9	-0.3	-0.1	-1.2	-0.1	-0.8	-0.9	-0.9
Illnesses of siblings	0.7	0.9	4.6	-0.2	-0.3	0.6	0.6	0.5	0.6	-2.1	-0.4	-2.1	-0.5	-0.6	0.1
Weight	0.7	3.3	15.8	-2.3	-3.1	-0.5	-4.0	-0.2	1.4	0.0	1.3	-1.4	-1.2	0.2	-1.4
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	4.1	-2.0	-0.8	-0.5	-0.7	-0.3	-0.2	-0.6	-0.4	-0.6	-1.0	-1.0	-1.4
Pulse wave peak to peak time	0.7	0.8	5.1	0.5	-0.5	0.0	-0.2	0.6	1.0	-2.3	1.3	-0.2	0.9	-0.8	-0.3
Illnesses of father: Heart disease	0.7	1.0	3.6	1.9	0.9	-0.8	1.8	-0.8	-1.0	-0.2	0.2	0.6	1.2	-0.4	-0.2
Smoking status: Previous	0.7	1.1	2.3	-1.3	0.3	-0.8	-1.3	-1.5	-0.2	-0.9	-0.5	-1.2	-0.7	-0.9	-1.5
Handedness (chirality/laterality): Left-handed	0.7	0.8	4.1	-0.1	0.4	0.1	1.3	0.5	1.0	-0.3	2.0	0.9	1.1	0.3	0.3
Medication for cholesterol	0.7	1.1	3.2	-1.7	-0.8	0.4	0.4	0.4	-0.0	-1.8	-0.6	-0.9	-0.8	-1.6	-1.0
Illnesses of father: None of the above (group 1)	0.7	0.8	5.2	-1.0	-1.1	-0.1	-2.3	-0.1	1.0	-0.5	-0.5	-0.4	-0.9	-0.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	8.0	1.1	1.2	-0.2	0.5	0.2	2.8	-0.4	1.3	1.5	1.5	0.2	0.8
Average weekly champagne plus white wine intake	0.7	0.9	1.7	1.2	1.0	0.5	1.1	0.7	0.4	0.8	1.2	1.1	1.3	0.8	0.9
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.6	-1.2	-0.6	1.0	0.2	0.9	-1.0	-1.1	-0.3	-1.2	-1.1	-0.9	-0.5
Medication: Blood pressure	0.7	1.3	5.3	1.4	-0.1	-0.1	-0.4	-0.0	0.4	2.3	0.3	1.9	0.5	1.7	0.9
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	3.0	-0.8	0.8	1.7	-0.3	1.1	-0.9	-0.1	0.3	-1.1	-0.7	-0.4	-1.3
Heart disease (siblings)	0.7	0.8	2.3	-0.7	-0.3	-1.5	-1.5	-1.5	-0.4	0.7	-0.9	0.5	-0.4	-0.5	-0.9
Neuroticism (Nagel 2018)	0.6	1.3	3.9	-1.1	-0.6	-0.8	-0.3	-1.5	-1.1	0.1	-1.1	-1.6	-2.0	-1.2	-1.1
Major Depression (MDD)	0.6	0.7	3.2	-0.4	-1.2	0.0	-1.8	0.1	0.6	1.6	0.0	0.1	-0.8	0.5	-0.1
HbA1C	0.6	0.6	3.5	-0.5	-0.5	-0.2	-0.7	-0.3	-0.5	-0.2	-1.9	-0.4	-0.9	-1.2	-0.6
Primary Biliary Cirrhosis	0.6	0.8	2.0	-0.5	0.4	1.4	-1.3	1.2	-1.2	1.0	0.7	0.5	-0.6	0.8	-0.4
Angina	0.6	0.7	2.0	0.8	-1.4	-1.4	0.3	-1.1	0.6	0.7	-0.5	-1.2	-0.2	-0.2	0.6
Maternal smoking around birth	0.6	0.8	2.3	-1.4	-0.2	-1.0	-1.4	-1.0	0.7	0.1	0.1	-0.9	-0.5	-0.5	-1.5
Fed-up feelings	0.6	1.1	3.7	-0.6	0.4	-0.8	0.8	-1.2	0.0	-1.6	-0.7	-1.5	-0.5	-1.9	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	3.6	0.4	0.2	1.3	-0.6	1.9	1.3	0.6	1.5	0.9	0.5	1.7	1.6
High blood pressure	0.6	1.7	6.4	-0.8	-0.5	-0.8	-0.4	-1.4	-1.8	2.5	-1.8	0.6	-1.1	0.1	-1.5
Mouth/teeth dental problems	0.6	1.0	3.2	1.0	1.8	1.1	0.9	0.8	-0.2	0.8	-0.4	1.3	0.7	0.9	0.9
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.9	0.8	0.5	-0.9	-0.0	-0.9	0.6	2.0	0.5	1.2	0.1	0.8	0.4
Worrier / anxious feelings	0.6	1.1	3.3	-0.9	-0.4	0.6	-0.5	0.1	-1.6	-0.4	-1.0	-1.4	-1.8	-1.3	-1.1
Noisy workplace	0.6	0.7	2.6	0.4	0.1	-1.1	-1.0	-1.0	0.7	1.6	0.0	0.3	0.5	1.1	0.8
Medication: Lansoprazole	0.6	0.7	2.0	0.3	1.4	1.3	-0.4	0.8	-0.4	-1.4	0.7	-0.6	0.2	-0.5	-0.4
Lung cancer (father)	0.6	0.8	2.4	-0.1	-1.0	-1.5	-0.7	-1.4	-0.5	-1.0	0.1	-0.9	0.0	-0.9	-0.7
Pulse wave Arterial Stiffness index	0.6	0.7	3.5	-0.7	0.4	0.3	-0.5	-0.4	-1.0	1.9	-0.9	-0.1	-1.1	0.7	-0.1
Length of working week for main job	0.6	0.6	1.9	-0.5	-0.5	-0.6	-1.4	-0.8	-0.8	-0.4	-0.4	-1.1	-0.6	-0.7	-1.0
Worry too long after embarrassment	0.6	1.0	2.9	-0.8	-0.5	-0.0	-1.7	-0.6	-0.5	-0.8	-1.1	-1.3	-1.3	-1.2	-0.7
Qualifications: College or University degree	0.6	1.8	11.0	-1.4	-3.3	-1.4	-1.6	-0.8	0.4	-0.2	-0.4	-1.0	-1.0	-0.5	-1.1
Emphysema/chronic bronchitis	0.6	0.7	2.5	0.3	1.6	1.5	1.4	0.9	-0.1	0.4	-0.1	-0.0	0.0	-0.0	0.7
Medication for pain relief, constipation, heartburn	0.6	1.1	3.3	1.6	0.2	-1.2	0.2	-0.5	0.4	-1.0	0.6	1.4	1.8	0.3	1.3
Angina (self-reported)	0.6	0.8	2.0	1.0	-1.4	-1.4	0.4	-1.0	0.9	1.0	-0.3	-0.9	0.1	0.1	0.7
Number of full sisters	0.6	0.8	2.3	1.3	0.9	-0.7	0.2	-0.1	1.5	0.4	0.4	1.3	1.1	0.0	0.7
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	3.0	-0.6	0.9	0.8	-0.3	-0.1	-1.7	0.2	-1.1	-0.3	-1.2	0.2	-1.0
Knee pain experienced in last month	0.6	0.9	4.8	-0.6	-0.2	-0.2	-2.2	-0.4	0.4	1.9	0.3	0.4	-0.6	1.0	-0.4
Hypertension (Self-reported)	0.6	1.6	8.8	-0.6	-0.2	-0.6	-0.2	-1.2	-1.8	3.0	-1.5	0.8	-1.0	0.4	-1.3
Illnesses of siblings: Diabetes	0.6	0.8	2.0	-0.3	0.1	-1.4	-0.5	-1.4	-0.9	-0.0	-1.2	-0.8	-0.5	-1.2	-0.8
Commuting to job workplace: Walk	0.6	0.6	1.6	1.2	0.4	0.4	-0.0	0.8	0.9	-0.5	0.1	0.1	1.3	0.6	1.3
Osteoporosis (self-reported)	0.6	0.7	2.3	-0.7	-0.6	0.2	-0.7	-0.4	-0.3	-0.7	-1.1	-1.5	-1.1	-0.6	-1.2
High cholesterol (Self-reported)	0.6	1.1	4.3	1.4	1.8	1.1	2.1	0.6	-0.2	0.1	0.8	0.1	1.1	0.7	0.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	4.1	-0.0	0.0	-0.5	-2.0	-0.3	1.9	-0.4	-0.1	-0.7	0.5	-0.3	0.1
Crohns Disease (2017)	0.5	1.1	2.2	0.1	1.4	0.7	1.3	0.8	0.8	1.5	1.2	0.8	1.2	1.0	0.8
Type 2 Diabetes (T2D) (2018)	0.5	0.9	4.0	0.6	0.8	1.1	0.8	0.9	0.3	2.0	0.1	0.9	0.3	1.3	0.6
Lung FEV1/FVC ratio	0.5	2.5	9.7	-0.1	-1.8	-3.1	0.2	-2.2	-0.4	-0.7	-3.0	-1.0	-0.1	-0.9	1.2
Lung FVC	0.5	2.5	11.2	-0.0	1.4	1.5	-1.1	1.0	2.9	-1.3	3.4	0.9	1.0	0.1	-0.6
Medication for hormone replacement therapy	0.5	0.6	2.9	0.6	-0.1	-1.7	-0.7	-1.6	0.5	0.2	0.3	-0.6	0.5	0.1	0.4
Current tobacco smoking	0.5	0.8	3.2	-0.1	-0.0	0.5	0.9	0.4	-1.8	-0.9	-1.7	-0.8	-0.3	-0.9	-0.1
Number of incorrect matches in round	0.5	0.8	3.4	0.7	-1.2	-1.8	-0.5	-1.7	0.5	-0.9	-0.4	-0.3	0.3	-0.5	-0.0
Hearing difficulty/problems with background noise	0.5	0.8	3.1	-1.1	0.3	1.0	0.6	1.0	-0.6	-1.0	-0.5	-0.9	-0.6	-1.8	-0.4
Qualifications: None of the above	0.5	1.1	4.3	0.3	0.7	0.6	1.0	0.0	-2.1	-1.4	-0.7	-1.6	-0.6	-0.9	-0.4
Diabetes (self-reported)	0.5	0.7	3.6	0.2	0.6	1.1	0.9	0.8	-0.4	1.9	-0.1	0.5	0.0	1.2	-0.1
Medication: Ramipril	0.5	0.6	2.6	-0.7	0.1	0.8	-1.2	0.4	-1.6	-0.6	-0.3	-0.2	-0.8	-0.4	-0.9
Medication: Simvastatin	0.5	0.7	2.1	1.2	1.0	-0.4	0.9	-0.9	0.6	1.4	0.1	0.4	0.5	1.0	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.6	0.4	-0.7	-0.4	1.0	0.2	1.3	-1.0	0.3	0.3	1.2	-0.3	0.6
Loud music exposure frequency	0.5	0.5	1.5	0.9	-0.1	-0.4	0.4	-0.0	1.2	0.3	0.9	0.7	0.9	0.3	0.9
Blood clot in the leg (DVT)	0.5	0.6	3.0	-0.2	-0.0	-0.4	-1.7	-0.2	1.6	-0.5	-0.0	-0.7	0.3	-0.4	-0.1
Number of children fathered	0.5	0.6	1.9	0.7	-0.2	-0.6	-0.8	-0.3	1.4	0.3	0.3	1.2	0.6	0.9	0.6
Medication: Omeprazole	0.5	0.6	1.9	-0.8	1.2	1.4	-0.3	0.6	-0.6	0.5	0.7	-0.7	-0.6	-0.1	-1.2
Medication: Seretide 50 evohaler	0.5	0.6	2.3	0.4	-1.5	-0.3	-1.2	-0.1	1.3	0.4	0.2	-0.5	-0.0	0.7	0.9
Family relationship satisfaction	0.5	0.6	2.8	-0.1	0.9	1.2	0.3	1.1	-0.1	0.4	1.7	0.1	0.5	0.6	-0.4
Loneliness, isolation	0.5	0.7	2.0	-0.4	0.4	-1.4	0.3	-1.0	1.2	-0.5	1.1	-0.4	0.4	-1.1	-0.5
Diabetes diagnosed by doctor	0.5	0.8	5.1	0.0	0.8	1.0	0.8	0.7	0.1	2.2	-0.2	0.4	-0.0	1.3	-0.2
Friendships satisfaction	0.5	0.6	1.7	1.2	-0.1	-1.0	-1.0	-0.8	1.3	0.5	0.3	0.9	0.9	0.3	0.1
Asthma (self-reported)	0.5	1.0	2.7	1.5	1.4	0.5	0.2	0.5	-0.2	1.6	1.3	0.8	0.6	1.4	0.4
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.0	1.0	0.9	0.7	0.8	0.6	1.0	0.2	1.4	1.0	0.6	0.6	0.1
Age started oral contraceptive pill	0.5	0.6	2.3	-0.4	-0.2	0.2	-0.9	-0.1	-0.7	1.3	-1.5	-0.1	-0.8	0.9	0.1
Vascular/heart problems diagnosed by doctor	0.5	1.5	8.7	0.6	0.5	0.7	0.3	1.1	1.5	-2.9	1.2	-0.9	0.9	-0.6	1.1
Supplements: Calcium	0.5	0.5	1.8	0.9	-0.9	-0.1	-0.4	0.1	0.7	1.3	1.0	0.3	0.2	0.9	0.3
Bipolar Disorder or Schizophrenia	0.4	1.0	4.0	0.1	0.2	0.1	-1.6	0.6	1.4	0.8	1.1	2.0	0.6	1.0	0.2
Depression (Nagel 2018)	0.4	0.6	1.8	-0.4	-0.2	-1.3	0.6	-1.2	0.4	1.3	0.6	0.7	-0.3	-0.1	0.0
Worry (Nagel 2018)	0.4	0.9	2.7	-0.9	-0.6	-0.7	-0.1	-1.0	-0.8	0.0	-1.4	-0.2	-1.6	-1.0	-1.2
Body Mass Index (BMI) (2010)	0.4	0.5	2.2	0.4	0.1	-1.2	-0.7	-1.1	0.4	0.7	-1.5	-0.3	0.0	0.3	0.3
Mean Putamen Volume	0.4	0.5	1.2	0.5	1.1	-0.1	0.2	-0.6	0.9	1.1	-0.4	0.8	1.1	0.3	0.2
Schizophrenia (2014)	0.4	0.8	4.6	0.4	-0.7	-0.5	-2.1	0.2	1.3	0.2	0.6	1.4	0.4	0.2	-0.2
Blood Eosinophil Count	0.4	3.4	10.0	1.6	2.8	3.2	1.4	3.0	-0.3	1.2	1.8	1.4	0.8	1.3	0.4
BMI	0.4	2.1	8.5	-0.7	-1.2	-2.9	-0.7	-2.3	1.5	1.8	-1.6	0.6	0.1	0.2	0.0
Cardiovascular Disease	0.4	1.2	9.7	-0.1	0.3	-0.0	-0.3	-0.8	-1.1	3.1	-0.6	0.6	-0.5	0.8	-1.1
Number of treatments/medications taken	0.4	0.8	3.8	0.0	0.6	1.5	0.3	0.8	-0.3	2.0	0.1	0.6	-0.5	1.1	-0.3
Ever had hysterectomy (womb removed)	0.4	0.4	1.2	-0.6	0.3	0.6	-1.1	0.6	0.6	-1.0	0.9	0.2	0.2	-0.6	0.1
Medication: Co-codamol	0.4	0.5	1.4	-0.2	-1.0	-1.2	-0.6	-1.2	0.1	-0.0	-0.8	-0.5	-0.3	-0.3	-0.7
Relative age voice broke	0.4	0.6	2.4	0.8	0.7	-0.2	-0.1	0.2	-0.1	0.3	0.9	1.6	1.3	0.9	0.8
Age when periods started (menarche)	0.4	1.0	2.4	-0.5	-1.6	-0.7	-1.4	-0.8	-0.7	-1.1	-0.5	-1.2	-0.9	-1.0	-1.0
Medication: Atenolol	0.4	0.5	4.0	0.2	0.5	0.5	-0.2	0.2	-0.7	2.0	-0.6	0.2	-0.6	0.5	-0.4
Waist circumference	0.4	1.5	6.6	-1.4	-1.7	-1.3	-2.6	-1.2	0.9	0.9	-0.4	-0.4	-0.6	0.4	-0.5
Had other major operations	0.4	0.5	2.6	-0.7	-0.8	-0.5	-1.6	-0.6	0.5	-0.4	-0.1	-0.6	-0.6	-0.3	-0.5
Hip circumference	0.4	1.7	8.1	-1.1	-1.9	-0.4	-2.9	0.2	1.9	0.9	1.2	-0.2	-0.1	0.9	-0.5
Time employed in main current job	0.4	0.5	0.9	0.1	-0.7	1.0	0.8	0.5	-0.9	0.8	-0.0	-0.6	-0.8	0.5	0.6
Asthma	0.4	0.9	2.3	1.5	1.5	0.4	0.4	0.3	-0.3	1.3	1.3	0.6	0.7	1.1	0.3
Exposure to tobacco smoke at home	0.4	0.5	1.4	-0.5	-0.5	-1.2	0.2	-0.9	0.4	0.8	-1.0	-0.0	-0.5	-0.0	-0.9
Medication: Paracetamol	0.4	0.6	2.1	-1.3	-0.1	0.6	-0.4	-0.1	-0.7	0.2	-0.4	-0.8	-1.5	-0.6	-1.2
Headache pain in last month	0.4	0.7	1.6	-0.1	0.6	1.0	-1.2	1.0	0.3	1.3	1.2	0.4	-0.2	1.1	0.5
Number of full brothers	0.4	0.6	2.2	1.1	1.5	0.7	-1.5	-0.0	-0.1	-0.1	-0.5	-0.1	0.4	0.4	0.3
Medication: Ibuprofen	0.4	0.5	2.5	-1.6	-0.8	-0.5	-0.8	-0.1	0.1	0.2	-0.6	-0.5	-0.8	-0.4	-0.8
Heart disease (mother)	0.4	0.5	2.8	-0.5	0.5	0.5	-0.3	0.1	-1.0	1.7	-0.4	-0.6	-0.7	0.4	-0.3
Chest pain or discomfort	0.4	0.6	2.7	0.1	-0.6	-0.7	-1.6	-0.4	1.0	1.3	0.3	-0.3	-0.0	0.3	-0.3
Had major operations	0.4	0.5	2.7	0.1	0.1	0.7	0.6	0.8	0.4	-0.2	1.6	1.2	0.5	0.3	0.1
Ever had bowel cancer screening	0.4	0.5	1.1	0.1	-0.5	-0.7	0.7	-0.4	0.8	1.0	0.7	-0.2	0.6	1.1	1.0
Breast cancer (self-reported)	0.4	0.5	1.6	0.7	-0.9	-0.3	-0.6	-0.1	1.3	-0.7	0.7	0.6	0.5	0.8	0.7
Medication: Aspirin	0.4	0.5	2.7	0.1	-0.2	0.8	0.5	0.3	0.0	1.6	-0.8	-0.5	-0.8	0.5	0.3
Hearing aid user	0.4	0.5	2.0	-0.8	0.5	0.5	0.3	0.3	-0.2	-1.4	-0.1	0.3	-0.5	-1.4	-0.1
Mother’s age at death	0.4	0.5	1.9	0.0	-1.1	0.0	-0.3	0.8	1.4	0.9	0.2	0.7	0.2	0.9	0.6
Medication: Paracetamol	0.4	0.7	2.4	-1.5	-1.0	0.2	-0.7	-0.4	-0.3	0.2	-0.5	-0.6	-1.5	-0.3	-0.9
Number of operations (self-reported)	0.4	0.6	1.8	-1.4	-0.6	0.2	-1.0	-0.3	-0.2	-0.8	0.3	-0.7	-1.0	-0.5	-1.0
Cholesterol lowering medication	0.4	0.5	1.9	0.6	0.7	0.1	1.3	-0.5	-1.4	0.2	-1.1	-0.7	-0.3	0.0	-0.5
Alzheimer’s Disease (including proxy)	0.3	0.5	1.3	-0.9	-0.6	0.1	0.4	-0.5	0.1	-0.8	-1.1	-1.1	-0.6	-0.9	-0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.3	0.5	-1.1	-0.9	-1.1	-0.8	0.6	1.1	0.3	1.1	-0.0	0.9	0.2
Breast Cancer	0.3	0.7	2.7	-0.3	-1.3	-0.7	-0.3	-0.8	0.1	-0.4	-0.2	-1.6	-1.2	-0.7	-0.2
Blood Red Count	0.3	3.1	19.8	-0.2	-0.1	-0.5	-2.6	-0.6	0.9	4.5	0.6	2.1	-0.3	2.2	0.2
Respiratory disease	0.3	0.6	2.6	0.5	1.6	0.9	0.3	0.6	-0.8	1.2	1.0	0.3	-0.1	0.4	-0.2
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.6	-0.3	0.2	-1.2	0.4	-1.2	0.0	-0.5	0.2	-0.2	0.1	-0.9	-0.2
Relative age of first facial hair	0.3	0.6	1.7	0.1	1.0	0.6	0.2	0.6	-1.1	0.8	-0.4	1.3	0.4	1.2	0.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	2.6	0.3	-0.9	-0.0	-0.3	0.0	1.6	0.7	0.5	-0.4	0.3	0.7	0.2
Body mass index (BMI)	0.3	1.2	3.5	-0.8	-1.2	-1.9	-0.7	-1.6	-0.2	1.6	-1.8	-0.0	-0.5	0.4	-0.1
Hair/balding pattern: Pattern 2	0.3	0.4	1.4	-0.4	-0.2	-0.5	-0.1	-1.0	-0.5	-0.1	-0.5	-1.2	-0.8	-0.5	-0.0
Had menopause	0.3	0.3	1.1	0.3	0.0	-0.9	0.5	-1.1	0.0	-0.6	-0.8	-0.4	0.1	-0.5	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	3.3	-0.4	-0.1	1.3	-0.8	1.8	0.7	-0.7	1.2	-0.3	-0.1	0.6	0.7
Financial difficulties in last 2 years	0.3	0.4	1.2	-0.3	0.1	0.9	-0.1	1.1	0.3	-0.7	1.1	-0.7	0.2	0.2	0.5
Pain all over the body in last month	0.3	0.4	1.2	1.0	0.3	-0.1	0.5	0.1	0.3	-0.0	0.1	1.1	1.0	0.8	0.1
Falls in the last year	0.3	0.4	2.2	-0.4	0.6	0.4	-0.5	0.6	0.5	0.5	1.5	0.4	0.4	1.0	0.3
Hair/balding pattern: Pattern 4	0.3	0.6	1.6	0.4	1.1	-0.5	0.4	-0.2	1.1	-1.3	0.8	1.0	1.1	-0.5	0.0
Peak expiratory flow (PEF)	0.3	0.8	2.3	-0.5	-0.6	1.1	-1.1	0.6	0.3	-0.9	1.5	-0.6	-0.4	-0.7	-1.3
Birth weight	0.3	0.6	2.3	-0.8	-1.2	-0.6	-1.5	-0.7	-0.2	-0.5	0.6	-1.2	-0.6	-0.2	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.1	-0.9	0.2	-0.4	-0.5	-0.4	0.6	0.3	-1.0	-0.8	-0.6	-0.3	0.4
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.9	-0.4	-0.8	-0.5	-0.5	-0.6	-0.6	0.3	-0.8	-0.2	-1.0	-0.2	-0.9
Neck or shoulder pain in last month	0.3	0.5	2.6	0.5	-0.1	0.4	-0.6	0.4	0.1	1.6	0.3	0.1	-0.1	1.0	0.9
Medication: Aspirin	0.3	0.3	1.4	0.0	0.1	0.9	0.9	0.2	-0.0	1.2	-0.6	-0.4	-0.6	0.2	0.1
Qualifications: nursing, teaching	0.3	0.5	1.7	0.0	-1.1	-0.4	-1.3	0.4	1.2	0.2	0.3	0.8	0.2	0.7	0.0
Mineral and other dietary supplements	0.3	0.4	1.6	0.1	0.7	0.5	0.4	0.6	-1.2	-0.5	-0.8	-0.4	0.4	-0.1	0.9
Osteoarthritis (self-reported)	0.3	0.3	1.1	-0.9	-0.8	-0.4	0.1	-0.6	1.1	0.3	0.1	-0.4	-0.5	-0.2	-0.5
Number of self-reported non-cancer illnesses	0.3	0.5	3.0	-0.3	0.5	0.3	0.1	-0.6	-0.2	1.7	-1.0	-0.1	-0.8	0.0	-1.1
Financial situation satisfaction	0.3	0.4	1.9	-0.0	0.7	0.4	1.4	0.3	-1.2	-0.2	-0.2	-0.4	0.4	-0.3	0.4
Commuting to job workplace: Public transport	0.3	0.4	1.3	0.1	1.1	0.8	0.4	0.4	0.4	-1.0	0.2	0.4	0.5	-0.6	-0.3
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.3	-0.1	-1.2	0.6	-0.8	0.4	0.8	0.6	0.6	-0.5	-0.5	0.7	0.5
Medication: Bendroflumethiazide	0.3	0.4	1.9	0.8	1.4	0.5	0.1	0.1	-0.5	0.9	0.0	1.1	0.2	0.1	-0.2
Depressed Affect (Nagel 2018)	0.2	0.5	1.1	-0.7	0.4	-0.2	0.4	-0.8	-0.9	0.1	-0.1	-1.0	-1.0	-0.8	-0.6
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.8	0.4	-0.8	0.1	-0.8	0.3	0.9	1.3	1.1	1.1	0.4	1.0	0.1
Schizophrenia (2018)	0.2	0.5	3.2	-0.0	-0.6	0.1	-1.8	0.4	0.4	-0.7	0.3	1.0	0.1	-0.2	-0.5
Schizophrenia vs Biploar Disorder	0.2	0.2	1.2	0.8	-1.1	0.2	-0.5	0.1	0.0	0.5	-0.1	0.2	-0.1	0.2	0.1
Bipolar Disorder (2011)	0.2	0.2	0.9	-0.6	-0.5	-0.1	-0.9	-0.2	-0.2	0.3	0.2	0.2	-0.4	0.4	-0.1
Fasting Glucose	0.2	0.3	1.0	0.8	0.5	0.3	1.0	0.2	-0.7	-0.4	-0.5	0.3	-0.1	-0.2	0.6
Chronotype (morning person)	0.2	0.5	2.7	0.1	0.6	0.8	0.8	1.0	0.2	0.7	0.2	1.6	0.1	0.2	-0.4
Hand grip strength (left)	0.2	0.6	2.6	-0.6	-1.6	0.1	-0.6	0.8	0.9	-0.9	0.9	-0.4	-0.1	0.2	0.0
Hearing difficulty/problems: Yes	0.2	0.3	1.6	0.0	1.3	0.0	0.1	0.5	0.4	-0.9	-0.2	-0.0	0.5	-1.0	-0.3
Trunk fat percentage	0.2	0.6	2.1	-0.4	0.5	1.2	-0.6	1.4	1.0	-0.1	1.4	-0.3	0.4	0.6	-0.1
Hand grip strength (right)	0.2	0.7	2.8	-0.6	-1.7	0.5	-1.0	0.9	0.6	0.8	0.4	-0.5	-0.5	1.0	0.5
Taking other prescription medications	0.2	0.3	1.2	-0.2	0.4	1.1	0.1	0.5	0.2	0.8	-0.2	-0.6	-0.6	0.0	-0.6
Trunk fat mass	0.2	1.0	3.5	-1.4	-0.7	0.7	-1.9	0.9	1.1	-0.3	1.5	-0.8	-0.2	0.4	-0.9
Alcohol intake versus 10 years previously	0.2	0.3	1.0	-0.1	-0.6	-0.1	-0.6	0.4	-0.1	0.9	1.0	0.1	0.1	0.8	0.1
Father’s age at death	0.2	0.3	1.0	0.3	-0.6	-0.3	0.6	-0.0	0.8	0.4	-0.5	0.6	0.2	0.7	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.9	0.2	-0.8	0.7	-0.5	0.7	0.4	0.9	0.7	-0.1	-0.2	-0.3	-0.5
Number of live births	0.2	0.4	1.5	0.8	-0.3	-1.1	-0.0	-1.2	-0.1	-0.0	-0.4	0.4	0.5	0.5	-0.1
Medication: Cholesterol lowering	0.2	0.4	2.0	0.4	0.4	-0.0	0.3	-0.1	0.7	1.4	0.0	0.1	0.2	1.0	0.4
Health satisfaction	0.2	0.2	1.1	-0.6	0.3	0.7	0.4	0.3	-0.4	-0.0	1.0	-0.5	0.1	-0.1	-0.4
Mean time to correctly identify matches	0.2	0.4	1.1	-0.4	-0.6	-1.0	0.6	-0.8	0.7	-0.7	-0.0	-0.4	-0.1	-0.7	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.9	0.3	0.0	-0.6	0.5	-0.5	-0.1	-0.2	1.0	0.5	0.8	0.1	0.4
Overall health rating	0.2	0.4	1.1	-0.3	0.6	1.0	0.1	1.0	-0.1	0.6	1.1	-0.3	-0.0	0.8	0.1
Miserableness	0.2	0.4	1.4	-0.2	0.1	1.0	-0.2	0.4	-1.0	-0.1	-0.4	-1.2	-1.0	-0.5	-0.1
Wears glasses or contact lenses	0.2	0.3	0.6	-0.7	-0.5	0.1	0.0	-0.2	-0.1	-0.7	-0.7	-0.5	-0.7	-0.3	-0.8
Fractured/broken bones in last 5 years	0.2	0.3	0.6	-0.6	0.1	0.4	0.4	0.1	-0.4	-0.7	-0.7	-0.8	-0.4	-0.6	-0.7
HDL Cholesterol	0.1	0.1	0.5	-0.0	-0.0	-0.3	-0.0	-0.2	-0.3	0.1	0.7	-0.5	-0.1	-0.2	0.4
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.4	-0.4	-0.2	-0.2	-0.4	0.2	0.7	-0.5	-0.2	0.5	0.4	0.1	-0.5
Heel T-Score	0.1	1.2	8.9	-0.3	-1.4	-0.6	-0.9	0.2	3.0	-0.5	1.0	0.6	-0.1	0.1	0.6
Hair Pigment	0.1	1.7	6.4	1.1	1.5	0.6	2.5	0.9	1.3	-1.1	1.3	0.4	1.7	0.8	1.2
Tanning	0.1	1.7	7.7	-1.0	0.8	-2.8	-0.4	-2.6	0.4	-1.0	0.4	0.5	0.7	-0.6	-1.0
Medication: Metformin	0.1	0.2	1.3	-0.1	-0.3	0.0	0.5	-0.1	-0.2	1.2	-0.5	-0.0	0.0	0.1	-0.7
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.6	0.2	-0.2	0.1	-0.1	0.1	-0.4	0.7	-0.2	-0.0	-0.5	0.8	0.5
Chronic bronchitis/emphysema (father)	0.1	0.1	0.6	-0.2	0.4	-0.1	-0.1	0.0	-0.4	-0.2	-0.7	-0.8	-0.4	-0.1	-0.2
Fluid intelligence score	0.1	0.2	0.6	0.1	-0.5	0.8	0.1	0.4	-0.6	-0.3	0.4	0.0	-0.5	-0.0	-0.5
Arm fat percentage (right)	0.1	0.3	0.7	0.2	0.8	0.0	0.1	0.2	0.8	0.8	-0.2	0.0	0.6	0.9	0.7
Arm fat mass (right)	0.1	0.6	2.5	-1.3	-1.0	-0.5	-1.6	-0.4	0.6	0.4	-0.2	-0.7	-0.4	0.2	-0.7
Gout (self-reported)	0.1	0.1	0.6	0.0	-0.2	-0.2	0.2	-0.5	0.5	0.2	-0.8	0.1	-0.2	0.3	-0.3
Body fat percentage	0.1	0.3	0.7	-0.2	0.8	0.7	0.0	0.8	0.5	0.1	0.7	-0.2	0.4	0.6	0.1
Leg fat percentage (right)	0.1	0.3	1.6	0.1	1.2	-0.2	0.6	-0.4	-0.3	0.7	-0.4	0.0	0.3	0.6	0.1
Wheeze or whistling in the chest in last year	0.1	0.3	0.8	-0.0	0.6	0.7	-0.2	0.7	-0.9	0.2	0.2	-0.7	-0.3	0.3	0.4
Whole body fat mass	0.1	0.6	2.3	-1.4	-0.7	0.2	-1.5	0.4	0.8	-0.0	0.9	-0.7	-0.2	0.3	-0.8
Leg fat mass (right)	0.1	0.3	0.8	-0.9	-0.2	-0.2	-0.9	-0.1	0.6	0.6	0.4	-0.2	0.0	0.6	-0.4
Arm fat mass (left)	0.1	0.5	2.0	-1.2	-0.9	-0.3	-1.4	-0.0	0.7	0.4	0.1	-0.5	-0.3	0.3	-0.5
Leg fat percentage (left)	0.1	0.3	1.2	-0.3	0.7	-0.7	0.5	-0.8	-0.8	0.1	-1.1	-0.5	-0.1	-0.1	-0.2
Average weekly beer plus cider intake	0.1	0.1	0.4	-0.1	-0.0	-0.2	-0.6	0.1	0.2	0.3	0.5	0.4	0.3	0.6	-0.1
Leg fat mass (left)	0.1	0.3	1.0	-1.0	-0.5	-0.5	-1.0	-0.4	0.4	0.1	0.0	-0.4	-0.1	0.2	-0.6
Waist Hip Ratio (WHR)	0.0	0.2	0.9	-0.1	0.9	-0.2	0.1	-1.0	-0.5	0.0	-0.3	0.0	-0.0	-0.4	-0.0
Arm fat percentage (left)	0.0	0.2	0.5	-0.1	0.7	0.2	0.2	0.3	0.5	0.6	-0.1	0.1	0.5	0.7	0.5

Hub : Genes

SMEK2

Models

Trait associations