Best TWAS P=4.1e-11 · Best GWAS P=2.23e-09 conditioned to 0.856
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | MYO9A | 0.06 | 0.03 | lasso | 2 | 0.01 | 4.7e-02 | 5.9 | -5.8 | 4.9e-09 | -0.98 | 0.04 | 0.89 | FALSE |
| 2 | GTEx | Artery Tibial | MYO9A | 0.07 | 0.08 | enet | 11 | 0.09 | 2.5e-07 | 6.0 | -5.8 | 5.0e-09 | -0.98 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | MYO9A | 0.19 | 0.02 | lasso | 8 | 0.03 | 9.4e-03 | 5.9 | -6.6 | 4.1e-11 | -0.89 | 0.04 | 0.89 | TRUE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | MYO9A | 0.13 | 0.08 | lasso | 3 | 0.08 | 1.7e-03 | 5.7 | -5.6 | 2.8e-08 | -0.93 | 0.06 | 0.91 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | MYO9A | 0.06 | 0.04 | lasso | 5 | 0.03 | 3.8e-03 | 5.1 | -5.3 | 1.4e-07 | -0.90 | 0.21 | 0.68 | FALSE |
| 6 | GTEx | Nerve Tibial | MYO9A | 0.13 | 0.13 | lasso | 3 | 0.11 | 2.1e-08 | 6.0 | -6.4 | 1.9e-10 | -0.93 | 0.01 | 0.99 | FALSE |
| 7 | GTEx | Stomach | MYO9A | 0.17 | 0.06 | lasso | 5 | 0.01 | 1.1e-01 | 5.8 | -6.1 | 9.9e-10 | -0.93 | 0.02 | 0.96 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NR2E3 | 0.03 | 0.06 | lasso | 1 | 0.05 | 3.8e-06 | 5.2 | -5.2 | 2.1e-07 | -0.87 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | NR2E3 | 0.07 | 0.02 | blup | 38 | 0.05 | 4.4e-03 | 5.7 | -5.6 | 2.1e-08 | -0.80 | 0.01 | 0.65 | FALSE |