[Hub]/) : Traits : Forced vital capacity (FVC) : ← →

chr15:73,524,629-78,022,087

Best TWAS P=7.45e-21 · Best GWAS P=6.9e-27 conditioned to 9.21e-19

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
57	GTEx	Thyroid	LOXL1-AS1	0.15	0.03	enet	40	0.03	2.6e-03	-8.1	9.4	7.5e-21	-0.33	0.12	0.21	TRUE
14	GTEx	Brain Cerebellar Hemisphere	MAN2C1	0.23	0.15	lasso	5	0.15	1.2e-04	6.8	7.2	6.2e-13	0.11	0.01	0.96	TRUE
25	GTEx	Cells Transformed fibroblasts	LOXL1-AS1	0.28	0.09	lasso	6	0.17	1.7e-12	3.3	6.7	2.4e-11	-0.64	1.00	0.00	TRUE
11	GTEx	Artery Tibial	CLK3	0.06	0.02	lasso	7	0.02	1.8e-02	-6.1	6.1	9.8e-10	0.08	0.05	0.87	TRUE
77	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RCN2	0.25	0.05	lasso	4	0.03	1.6e-02	5.5	-5.6	1.8e-08	0.03	0.00	0.68	TRUE
52	GTEx	Testis	LOXL1-AS1	0.36	0.15	lasso	10	0.13	2.4e-06	-8.1	-8.3	1.2e-16	0.58	0.51	0.07	FALSE
48	GTEx	Skin Sun Exposed Lower leg	LOXL1-AS1	0.11	0.05	enet	11	0.10	7.3e-09	1.8	6.9	4.0e-12	-0.41	0.82	0.08	FALSE
2	GTEx	Adipose Subcutaneous	NEIL1	0.05	0.03	lasso	5	0.02	1.6e-02	6.0	6.6	4.1e-11	0.11	0.11	0.87	FALSE
12	GTEx	Artery Tibial	LOXL1-AS1	0.12	0.11	enet	19	0.12	2.4e-09	-8.1	6.3	2.3e-10	-0.49	0.98	0.01	FALSE
41	GTEx	Nerve Tibial	MAN2C1	0.37	0.52	enet	20	0.53	5.6e-44	6.1	6.2	4.6e-10	0.10	0.13	0.87	FALSE
43	GTEx	Pancreas	MAN2C1	0.39	0.41	lasso	1	0.39	1.0e-17	6.1	6.1	8.0e-10	0.11	0.13	0.87	FALSE
15	GTEx	Brain Frontal Cortex BA9	MAN2C1	0.27	0.25	lasso	3	0.21	2.8e-06	6.1	6.1	8.1e-10	0.10	0.14	0.84	FALSE
34	GTEx	Esophagus Muscularis	MAN2C1	0.55	0.60	lasso	3	0.62	3.6e-47	6.1	6.1	9.6e-10	0.10	0.12	0.88	FALSE
29	GTEx	Colon Transverse	SNUPN	0.15	0.12	lasso	3	0.08	7.7e-05	6.1	6.1	9.9e-10	0.10	0.15	0.84	FALSE
44	GTEx	Pituitary	MAN2C1	0.31	0.37	lasso	5	0.34	2.1e-09	6.0	6.1	1.0e-09	0.09	0.14	0.85	FALSE
10	GTEx	Artery Tibial	MAN2C1	0.33	0.45	lasso	4	0.44	9.2e-38	6.1	6.1	1.2e-09	0.10	0.14	0.86	FALSE
36	GTEx	Heart Left Ventricle	MAN2C1	0.18	0.19	lasso	4	0.16	4.8e-09	6.1	6.1	1.2e-09	0.10	0.14	0.86	FALSE
47	GTEx	Skin Sun Exposed Lower leg	MAN2C1	0.30	0.36	enet	17	0.38	1.6e-32	5.8	6.1	1.2e-09	0.10	0.21	0.79	FALSE
8	GTEx	Artery Aorta	MAN2C1	0.48	0.60	lasso	5	0.59	7.1e-40	6.1	6.1	1.3e-09	0.11	0.12	0.88	FALSE
6	GTEx	Adrenal Gland	MAN2C1	0.20	0.24	lasso	6	0.21	4.3e-08	6.0	6.1	1.4e-09	0.12	0.14	0.86	FALSE
16	GTEx	Brain Hippocampus	MAN2C1	0.21	0.26	lasso	3	0.26	9.4e-07	6.0	6.1	1.4e-09	0.09	0.14	0.79	FALSE
23	GTEx	Cells Transformed fibroblasts	MAN2C1	0.38	0.50	lasso	4	0.49	6.2e-42	6.1	6.1	1.4e-09	0.10	0.15	0.85	FALSE
32	GTEx	Esophagus Mucosa	MAN2C1	0.27	0.38	lasso	2	0.39	9.9e-28	6.1	6.1	1.4e-09	0.10	0.14	0.86	FALSE
50	GTEx	Stomach	MAN2C1	0.36	0.45	lasso	3	0.46	2.0e-24	6.0	6.0	1.4e-09	0.10	0.14	0.86	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	MAN2C1	0.14	0.17	lasso	3	0.12	3.3e-04	6.0	6.0	1.5e-09	0.09	0.13	0.75	FALSE
35	GTEx	Heart Atrial Appendage	MAN2C1	0.30	0.28	lasso	5	0.29	1.8e-13	6.0	6.0	1.5e-09	0.09	0.14	0.86	FALSE
38	GTEx	Lung	MAN2C1	0.33	0.51	lasso	3	0.50	2.1e-43	6.0	6.0	1.5e-09	0.09	0.21	0.79	FALSE
73	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SNUPN	0.14	0.10	lasso	4	0.08	1.1e-04	6.1	6.0	1.6e-09	0.10	0.15	0.79	FALSE
28	GTEx	Colon Transverse	MAN2C1	0.42	0.55	lasso	6	0.54	8.1e-30	6.0	6.0	1.7e-09	0.11	0.13	0.87	FALSE
60	GTEx	Whole Blood	MAN2C1	0.28	0.29	lasso	5	0.29	3.2e-27	6.0	6.0	1.7e-09	0.09	0.17	0.83	FALSE
63	NTR	Blood	MAN2C1	0.02	0.03	lasso	2	0.03	1.5e-10	6.0	6.0	1.7e-09	0.10	0.16	0.84	FALSE
1	CommonMind	Brain Pre-frontal Cortex	MAN2C1	0.13	0.17	lasso	5	0.18	2.5e-21	6.0	6.0	1.8e-09	0.10	0.17	0.83	FALSE
68	The Cancer Genome Atlas	Colon Adenocarcinoma	SNUPN	0.11	0.10	lasso	4	0.11	6.9e-07	6.0	6.0	1.8e-09	0.12	0.14	0.85	FALSE
53	GTEx	Thyroid	NEIL1	0.06	0.06	lasso	2	0.07	9.0e-06	6.0	6.0	2.0e-09	0.11	0.17	0.80	FALSE
62	METSIM	Adipose	MAN2C1	0.22	0.41	lasso	6	0.41	1.1e-66	6.0	6.0	2.0e-09	0.10	0.14	0.86	FALSE
69	The Cancer Genome Atlas	Esophageal Carcinoma	SNUPN	0.18	0.11	lasso	5	0.07	2.6e-03	6.0	6.0	2.0e-09	0.10	0.05	0.45	FALSE
56	GTEx	Thyroid	RP11-817O13.6	0.05	0.05	lasso	1	0.03	1.3e-03	6.0	6.0	2.2e-09	0.11	0.15	0.67	FALSE
5	GTEx	Adipose Visceral Omentum	MAN2C1	0.46	0.52	lasso	5	0.52	1.8e-31	6.0	6.0	2.4e-09	0.09	0.15	0.85	FALSE
31	GTEx	Esophagus Gastroesophageal Junction	MAN2C1	0.37	0.49	lasso	2	0.49	7.3e-20	6.0	6.0	2.4e-09	0.09	0.17	0.83	FALSE
45	GTEx	Prostate	MAN2C1	0.26	0.30	lasso	3	0.33	4.6e-09	6.0	6.0	2.4e-09	0.09	0.18	0.80	FALSE
26	GTEx	Colon Sigmoid	MAN2C1	0.36	0.46	lasso	3	0.45	1.9e-17	6.0	6.0	2.6e-09	0.09	0.14	0.86	FALSE
18	GTEx	Breast Mammary Tissue	MAN2C1	0.42	0.54	lasso	5	0.52	4.6e-31	6.1	6.0	2.7e-09	0.10	0.12	0.88	FALSE
79	The Cancer Genome Atlas	Prostate Adenocarcinoma	NEIL1	0.05	0.05	lasso	3	0.05	9.0e-06	6.0	5.9	2.7e-09	0.11	0.00	1.00	FALSE
20	GTEx	Breast Mammary Tissue (Female)	MAN2C1	0.39	0.41	lasso	6	0.45	7.6e-15	5.8	5.9	2.8e-09	0.10	0.20	0.80	FALSE
30	GTEx	Colon Transverse	CTD-2323K18.1	0.13	0.04	lasso	11	0.05	1.8e-03	6.1	5.9	2.8e-09	0.10	0.13	0.64	FALSE
59	GTEx	Vagina	MAN2C1	0.31	0.30	enet	6	0.27	5.6e-07	6.0	5.9	2.9e-09	0.10	0.14	0.84	FALSE
51	GTEx	Testis	MAN2C1	0.25	0.26	lasso	4	0.28	1.1e-12	6.1	5.9	3.4e-09	0.09	0.13	0.87	FALSE
19	GTEx	Breast Mammary Tissue (Male)	MAN2C1	0.37	0.38	lasso	3	0.34	9.7e-09	6.1	5.9	4.2e-09	0.09	0.15	0.84	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	MAN2C1	0.39	0.44	lasso	4	0.44	1.2e-26	6.0	5.9	4.2e-09	0.09	0.16	0.84	FALSE
9	GTEx	Artery Coronary	MAN2C1	0.54	0.39	lasso	7	0.35	1.7e-12	6.1	5.9	4.3e-09	0.09	0.13	0.87	FALSE
24	GTEx	Cells Transformed fibroblasts	IMP3	0.05	0.06	lasso	2	0.05	1.3e-04	5.8	-5.9	4.3e-09	-0.08	0.20	0.56	FALSE
49	GTEx	Spleen	MAN2C1	0.70	0.62	lasso	5	0.57	1.2e-17	6.1	5.9	4.6e-09	0.10	0.14	0.86	FALSE
4	GTEx	Adipose Visceral Omentum	NEIL1	0.09	0.03	lasso	3	0.05	2.0e-03	6.1	5.8	5.7e-09	0.08	0.13	0.71	FALSE
58	GTEx	Uterus	MAN2C1	0.52	0.56	lasso	2	0.61	1.4e-15	6.0	5.8	6.9e-09	0.09	0.16	0.84	FALSE
80	The Cancer Genome Atlas	Prostate Adenocarcinoma	SNUPN	0.13	0.09	blup	38	0.12	6.0e-13	-3.0	5.8	7.1e-09	0.10	0.94	0.06	FALSE
40	GTEx	Muscle Skeletal	MAN2C1	0.05	0.01	enet	6	0.03	5.6e-04	5.8	5.8	7.4e-09	0.07	0.16	0.74	FALSE
54	GTEx	Thyroid	MAN2C1	0.44	0.53	lasso	6	0.55	3.1e-49	6.0	5.7	9.1e-09	0.10	0.16	0.84	FALSE
76	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MAN2C1	0.08	0.02	blup	14	0.04	1.3e-02	6.0	5.7	1.0e-08	0.10	0.00	0.76	FALSE
83	The Cancer Genome Atlas	Thyroid Carcinoma	SNUPN	0.19	0.12	enet	11	0.20	1.1e-19	-3.0	5.7	1.1e-08	0.09	0.67	0.33	FALSE
39	GTEx	Lung	SNUPN	0.14	0.06	lasso	2	0.07	2.7e-06	5.8	5.7	1.2e-08	0.08	0.20	0.78	FALSE
55	GTEx	Thyroid	SNUPN	0.15	0.10	lasso	7	0.16	6.2e-12	-3.3	5.7	1.3e-08	0.10	0.40	0.60	FALSE
64	YFS	Blood	IMP3	0.02	0.01	enet	9	0.02	5.9e-06	5.2	-5.7	1.4e-08	-0.08	0.31	0.62	FALSE
27	GTEx	Colon Transverse	RCN2	0.20	0.04	enet	21	0.08	1.8e-04	5.1	-5.6	1.9e-08	0.07	0.07	0.59	FALSE
37	GTEx	Liver	MAN2C1	0.37	0.24	lasso	5	0.21	1.6e-06	6.1	5.6	2.1e-08	0.09	0.14	0.80	FALSE
66	The Cancer Genome Atlas	Breast Invasive Carcinoma	TSPAN3	0.03	0.01	blup	43	0.01	8.2e-03	4.0	-5.6	2.8e-08	0.06	0.09	0.08	FALSE
13	GTEx	Brain Caudate basal ganglia	MAN2C1	0.23	0.24	enet	20	0.22	7.9e-07	6.1	5.5	3.0e-08	0.07	0.12	0.85	FALSE
3	GTEx	Adipose Subcutaneous	MAN2C1	0.36	0.54	enet	18	0.54	2.7e-52	6.0	5.5	3.3e-08	0.10	0.17	0.83	FALSE
42	GTEx	Nerve Tibial	RP11-817O13.6	0.05	0.03	lasso	2	0.01	3.5e-02	6.0	5.5	3.3e-08	0.09	0.16	0.60	FALSE
67	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MAN2C1	0.12	0.11	blup	14	0.12	1.4e-06	6.0	5.5	4.3e-08	0.09	0.00	1.00	FALSE
33	GTEx	Esophagus Mucosa	LOXL1-AS1	0.30	0.03	enet	37	0.05	2.0e-04	0.3	5.4	6.7e-08	-0.37	0.18	0.07	FALSE
78	The Cancer Genome Atlas	Prostate Adenocarcinoma	MAN2C1	0.07	0.04	blup	15	0.05	6.6e-06	-2.7	5.4	7.7e-08	0.07	0.12	0.62	FALSE
7	GTEx	Adrenal Gland	SNUPN	0.17	0.05	enet	17	0.11	1.3e-04	-1.9	5.3	8.9e-08	0.07	0.06	0.15	FALSE
71	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAN2C1	0.08	0.06	blup	14	0.09	2.0e-10	6.0	5.3	1.1e-07	0.10	0.00	1.00	FALSE
72	The Cancer Genome Atlas	Brain Lower Grade Glioma	UBL7	0.04	0.00	blup	34	0.01	3.9e-02	-5.9	-5.3	1.2e-07	-0.07	0.01	0.75	FALSE
74	The Cancer Genome Atlas	Lung Adenocarcinoma	SNUPN	0.03	0.03	enet	8	0.02	9.9e-04	5.8	5.3	1.5e-07	0.06	0.12	0.66	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	SNUPN	0.20	0.02	enet	16	0.08	1.4e-03	5.8	5.2	1.7e-07	0.08	0.12	0.60	FALSE
70	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SNUPN	0.11	0.06	blup	38	0.06	3.9e-04	6.1	5.2	1.7e-07	0.12	0.05	0.71	FALSE
81	The Cancer Genome Atlas	Stomach Adenocarcinoma	SCAPER	0.18	0.01	blup	151	0.02	2.2e-02	4.9	-5.2	1.8e-07	0.03	0.01	0.93	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	PSTPIP1	0.13	0.04	enet	13	0.10	4.0e-04	5.5	-5.2	2.1e-07	0.08	0.09	0.70	FALSE
61	GTEx	Whole Blood	LOXL1-AS1	0.10	0.00	enet	33	0.00	5.8e-01	9.1	5.2	2.4e-07	-0.21	0.05	0.11	FALSE
75	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SCAPER	0.06	0.00	enet	5	0.00	3.4e-01	4.9	-5.2	2.5e-07	0.04	0.02	0.24	FALSE
82	The Cancer Genome Atlas	Thyroid Carcinoma	MAN2C1	0.09	0.05	blup	13	0.06	3.1e-06	-2.7	5.2	2.5e-07	0.07	0.08	0.77	FALSE
65	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNUPN	0.04	0.02	lasso	3	0.03	3.3e-06	-3.0	5.1	3.1e-07	0.07	0.34	0.49	FALSE