Best TWAS P=3.58e-08 · Best GWAS P=5.76e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | NARFL | 0.20 | 0.30 | lasso | 2 | 0.29 | 2.6e-15 | 5.4 | 5.4 | 7.1e-08 | 1.00 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Artery Aorta | NARFL | 0.41 | 0.36 | lasso | 7 | 0.35 | 4.6e-20 | 5.4 | 5.4 | 5.2e-08 | 1.00 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Artery Coronary | NARFL | 0.26 | 0.16 | lasso | 6 | 0.05 | 1.1e-02 | 5.4 | 5.3 | 9.4e-08 | 0.98 | 0.00 | 0.98 | FALSE |
| 4 | GTEx | Artery Tibial | NARFL | 0.14 | 0.16 | lasso | 2 | 0.15 | 1.2e-11 | 5.4 | 5.4 | 5.7e-08 | 1.00 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Brain Cerebellum | NARFL | 0.23 | 0.27 | lasso | 2 | 0.24 | 1.3e-07 | 5.4 | 5.4 | 7.8e-08 | 1.00 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Colon Sigmoid | NARFL | 0.40 | 0.40 | lasso | 2 | 0.33 | 1.9e-12 | 5.4 | 5.4 | 5.3e-08 | 1.00 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Esophagus Gastroesophageal Junction | NARFL | 0.24 | 0.20 | lasso | 2 | 0.16 | 1.9e-06 | 5.4 | 5.4 | 5.8e-08 | 1.00 | 0.00 | 0.99 | FALSE |
| 8 | GTEx | Esophagus Muscularis | NARFL | 0.24 | 0.30 | lasso | 3 | 0.26 | 9.3e-16 | 5.4 | 5.4 | 6.5e-08 | 1.00 | 0.00 | 1.00 | FALSE |
| 9 | GTEx | Heart Atrial Appendage | NARFL | 0.42 | 0.18 | lasso | 3 | 0.15 | 2.1e-07 | 5.4 | 5.2 | 1.5e-07 | 0.89 | 0.00 | 1.00 | FALSE |
| 10 | GTEx | Heart Left Ventricle | HAGHL | 0.25 | 0.15 | lasso | 4 | 0.12 | 7.7e-07 | 5.1 | 5.1 | 2.8e-07 | 0.86 | 0.01 | 0.99 | FALSE |
| 11 | GTEx | Lung | NARFL | 0.36 | 0.32 | lasso | 7 | 0.31 | 3.4e-24 | 5.4 | 5.4 | 6.3e-08 | 0.99 | 0.00 | 1.00 | FALSE |
| 12 | GTEx | Nerve Tibial | NARFL | 0.44 | 0.35 | lasso | 5 | 0.34 | 2.9e-25 | 5.4 | 5.5 | 4.6e-08 | 0.99 | 0.00 | 1.00 | FALSE |
| 13 | GTEx | Ovary | NARFL | 0.51 | 0.44 | lasso | 6 | 0.43 | 9.3e-12 | 5.4 | 5.2 | 2.0e-07 | 0.99 | 0.00 | 1.00 | FALSE |
| 14 | GTEx | Spleen | NARFL | 0.45 | 0.34 | enet | 7 | 0.37 | 2.4e-10 | 5.3 | 5.4 | 5.9e-08 | 0.94 | 0.00 | 0.99 | FALSE |
| 15 | GTEx | Stomach | NARFL | 0.16 | 0.19 | lasso | 4 | 0.17 | 1.5e-08 | 5.4 | 5.5 | 4.4e-08 | 1.00 | 0.00 | 1.00 | FALSE |
| 16 | GTEx | Testis | NARFL | 0.41 | 0.45 | lasso | 4 | 0.44 | 1.4e-21 | 5.4 | 5.3 | 1.3e-07 | 0.99 | 0.00 | 1.00 | FALSE |
| 17 | GTEx | Thyroid | NARFL | 0.32 | 0.38 | lasso | 1 | 0.38 | 4.1e-30 | 5.4 | 5.4 | 5.8e-08 | 1.00 | 0.00 | 1.00 | FALSE |
| 18 | GTEx | Uterus | NARFL | 0.41 | 0.34 | lasso | 1 | 0.32 | 2.7e-07 | 5.4 | 5.4 | 5.8e-08 | 1.00 | 0.00 | 0.98 | FALSE |
| 19 | GTEx | Whole Blood | NARFL | 0.11 | 0.06 | lasso | 3 | 0.06 | 7.4e-06 | 5.4 | 5.5 | 3.6e-08 | 0.99 | 0.00 | 1.00 | TRUE |
| 20 | METSIM | Adipose | HAGHL | 0.10 | 0.07 | lasso | 2 | 0.06 | 5.6e-10 | 5.1 | 5.4 | 7.5e-08 | 0.84 | 0.01 | 0.99 | FALSE |
| 21 | YFS | Blood | METRN | 0.05 | 0.06 | lasso | 2 | 0.06 | 2.0e-18 | 5.1 | 5.4 | 8.5e-08 | 0.91 | 0.01 | 0.99 | FALSE |
| 22 | YFS | Blood | NARFL | 0.16 | 0.19 | lasso | 3 | 0.19 | 1.1e-60 | 5.4 | 5.5 | 4.2e-08 | 0.97 | 0.00 | 1.00 | FALSE |
| 23 | The Cancer Genome Atlas | Breast Invasive Carcinoma | METRN | 0.02 | 0.02 | lasso | 1 | 0.02 | 2.0e-04 | 5.1 | 5.1 | 2.8e-07 | 0.85 | 0.01 | 0.96 | FALSE |
| 24 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HAGHL | 0.03 | 0.01 | blup | 41 | 0.01 | 2.2e-02 | 5.1 | 5.3 | 1.0e-07 | 0.78 | 0.02 | 0.75 | FALSE |