[Hub]/) : Traits : Forced vital capacity (FVC) :

chr16:2,510,603-5,510,848

Best TWAS P=1.2e-15 · Best GWAS P=3.88e-14 conditioned to 0.0039

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CLUAP1 0.26 0.17 enet 24 0.17 2.9e-20 -6.7 -7.0 3.4e-12 0.66 0.37 0.63 FALSE
2 CommonMind Brain Pre-frontal Cortex NLRC3 0.44 0.40 lasso 3 0.40 9.3e-53 -6.7 6.5 1.0e-10 -0.73 0.37 0.63 FALSE
3 GTEx Adipose Subcutaneous CLUAP1 0.42 0.32 enet 35 0.35 1.2e-29 -6.7 -8.0 1.2e-15 0.70 0.37 0.63 TRUE
4 GTEx Adipose Visceral Omentum CLUAP1 0.25 0.17 enet 16 0.16 7.7e-09 -6.7 -6.1 1.2e-09 0.69 0.21 0.78 FALSE
5 GTEx Adrenal Gland ZNF500 0.11 0.07 enet 15 0.01 9.6e-02 5.9 6.0 2.5e-09 0.04 0.00 0.96 TRUE
6 GTEx Adrenal Gland NLRC3 0.28 0.06 lasso 3 0.02 6.0e-02 -6.6 6.1 1.4e-09 -0.66 0.05 0.31 FALSE
7 GTEx Artery Aorta CLUAP1 0.40 0.33 enet 18 0.33 5.4e-19 -6.7 -7.5 4.7e-14 0.74 0.37 0.63 FALSE
8 GTEx Artery Coronary CLUAP1 0.31 0.26 enet 13 0.25 6.8e-09 -6.7 -6.3 3.2e-10 0.74 0.11 0.87 FALSE
9 GTEx Artery Tibial CLUAP1 0.45 0.29 enet 47 0.31 5.2e-25 -6.7 -7.0 3.0e-12 0.66 0.37 0.63 FALSE
10 GTEx Artery Tibial NLRC3 0.39 0.26 lasso 7 0.36 1.5e-29 -6.7 5.9 4.9e-09 -0.67 0.37 0.63 FALSE
11 GTEx Brain Caudate basal ganglia NLRC3 0.41 0.11 lasso 4 0.24 2.0e-07 -6.7 6.6 4.9e-11 -0.71 0.16 0.65 FALSE
12 GTEx Brain Cerebellar Hemisphere ZNF500 0.27 0.13 enet 13 0.12 4.4e-04 4.1 5.3 9.7e-08 0.03 0.05 0.86 FALSE
13 GTEx Brain Cerebellar Hemisphere NLRC3 0.40 0.39 lasso 2 0.40 2.1e-11 -6.7 7.0 2.2e-12 -0.76 0.03 0.97 FALSE
14 GTEx Brain Cerebellum NLRC3 0.36 0.36 lasso 4 0.36 1.4e-11 -6.7 7.0 2.1e-12 -0.76 0.05 0.95 FALSE
15 GTEx Brain Cerebellum SLX4 0.33 0.14 lasso 3 0.10 6.8e-04 -6.3 6.7 1.8e-11 -0.75 0.03 0.82 FALSE
16 GTEx Brain Cortex ZNF500 0.18 0.02 enet 8 0.04 2.5e-02 -4.0 5.4 6.5e-08 0.05 0.04 0.50 FALSE
17 GTEx Brain Cortex NLRC3 0.30 0.34 lasso 1 0.31 2.3e-09 -6.7 6.7 2.6e-11 -0.73 0.07 0.92 FALSE
18 GTEx Brain Frontal Cortex BA9 NLRC3 0.50 0.18 enet 30 0.33 1.6e-09 -6.6 5.8 7.9e-09 -0.70 0.01 0.99 FALSE
19 GTEx Brain Hippocampus CLUAP1 0.37 0.10 lasso 5 0.09 4.9e-03 -7.6 -7.6 3.3e-14 0.89 0.00 0.97 FALSE
20 GTEx Brain Hippocampus NLRC3 0.49 0.28 lasso 5 0.34 8.0e-09 -6.7 6.3 3.6e-10 -0.65 0.03 0.84 FALSE
21 GTEx Brain Hypothalamus CLUAP1 0.47 0.31 lasso 8 0.32 3.3e-08 -6.7 -6.6 3.1e-11 0.73 0.06 0.77 FALSE
22 GTEx Brain Hypothalamus NLRC3 0.38 0.15 lasso 6 0.17 8.3e-05 -6.7 6.7 2.1e-11 -0.74 0.06 0.64 FALSE
23 GTEx Brain Nucleus accumbens basal ganglia MGRN1 0.39 0.25 lasso 5 0.26 1.4e-07 5.2 -5.4 8.7e-08 0.01 0.01 0.99 FALSE
24 GTEx Brain Nucleus accumbens basal ganglia NLRC3 0.24 0.14 enet 6 0.22 1.1e-06 -6.7 6.2 5.3e-10 -0.69 0.04 0.88 FALSE
25 GTEx Breast Mammary Tissue ZNF500 0.18 0.10 lasso 3 0.10 5.0e-06 5.9 5.5 4.1e-08 -0.02 0.00 1.00 FALSE
26 GTEx Breast Mammary Tissue CLUAP1 0.26 0.13 lasso 8 0.13 4.6e-07 -6.7 -6.7 1.9e-11 0.79 0.29 0.71 FALSE
27 GTEx Breast Mammary Tissue (Female) CLUAP1 0.35 0.14 lasso 8 0.12 2.3e-04 -6.7 -6.2 7.4e-10 0.69 0.10 0.67 FALSE
28 GTEx Cells Transformed fibroblasts ZNF500 0.17 0.12 enet 19 0.16 3.0e-12 4.4 5.2 1.8e-07 0.02 0.23 0.76 FALSE
29 GTEx Cells Transformed fibroblasts CLUAP1 0.56 0.35 lasso 10 0.39 1.7e-30 -6.7 -6.4 1.7e-10 0.69 0.37 0.63 FALSE
30 GTEx Colon Sigmoid CLUAP1 0.47 0.32 lasso 9 0.34 1.1e-12 -6.6 -7.3 3.9e-13 0.78 0.42 0.58 FALSE
31 GTEx Colon Transverse CLUAP1 0.25 0.09 lasso 3 0.14 2.0e-07 -6.7 -6.0 1.6e-09 0.67 0.14 0.85 FALSE
32 GTEx Esophagus Gastroesophageal Junction CLUAP1 0.58 0.36 lasso 9 0.38 1.5e-14 -6.7 -7.0 1.8e-12 0.73 0.36 0.64 FALSE
33 GTEx Esophagus Gastroesophageal Junction NLRC3 0.29 0.16 lasso 3 0.18 5.1e-07 -6.7 6.8 9.9e-12 -0.75 0.10 0.87 FALSE
34 GTEx Esophagus Mucosa CLUAP1 0.30 0.18 lasso 7 0.19 1.3e-12 -6.7 -6.9 6.0e-12 0.75 0.42 0.58 FALSE
35 GTEx Esophagus Muscularis CLUAP1 0.42 0.42 lasso 2 0.44 4.8e-29 -6.7 -7.0 2.8e-12 0.75 0.37 0.63 FALSE
36 GTEx Esophagus Muscularis NLRC3 0.48 0.29 lasso 6 0.36 5.1e-23 -6.7 6.5 6.9e-11 -0.71 0.38 0.62 FALSE
37 GTEx Heart Atrial Appendage CLUAP1 0.40 0.16 enet 13 0.29 2.3e-13 -6.6 -7.4 1.6e-13 0.79 0.42 0.58 FALSE
38 GTEx Heart Atrial Appendage NLRC3 0.27 0.07 lasso 3 0.08 2.2e-04 -6.7 7.1 1.3e-12 -0.80 0.01 0.98 FALSE
39 GTEx Heart Atrial Appendage NUDT16L1 0.12 0.17 lasso 1 0.17 4.8e-08 5.9 -5.9 4.2e-09 0.02 0.00 1.00 FALSE
40 GTEx Heart Left Ventricle CLUAP1 0.39 0.30 lasso 6 0.34 1.4e-18 -6.7 -7.2 8.6e-13 0.80 0.35 0.65 FALSE
41 GTEx Lung CLUAP1 0.16 0.10 enet 9 0.12 2.1e-09 -6.7 -7.5 7.1e-14 0.81 0.38 0.62 FALSE
42 GTEx Lung ZSCAN32 0.08 0.02 lasso 3 0.02 6.3e-03 -6.3 -6.9 3.8e-12 0.58 0.09 0.25 FALSE
43 GTEx Muscle Skeletal ZNF213 0.17 0.00 enet 22 0.03 1.0e-03 -3.8 -5.2 1.8e-07 0.03 0.43 0.02 TRUE
44 GTEx Muscle Skeletal CLUAP1 0.21 0.19 lasso 6 0.20 3.8e-19 -6.7 -7.2 7.2e-13 0.79 0.37 0.63 FALSE
45 GTEx Muscle Skeletal NLRC3 0.16 0.11 lasso 2 0.11 7.9e-11 -6.7 6.7 2.3e-11 -0.74 0.37 0.63 FALSE
46 GTEx Muscle Skeletal AC006111.1 0.29 0.07 enet 22 0.20 2.2e-19 2.5 -5.5 3.3e-08 0.57 0.24 0.76 FALSE
47 GTEx Nerve Tibial CLUAP1 0.53 0.27 lasso 7 0.42 9.9e-32 -6.7 -7.0 2.6e-12 0.75 0.46 0.54 FALSE
48 GTEx Nerve Tibial NLRC3 0.29 0.24 lasso 3 0.32 8.7e-23 -6.7 6.5 8.5e-11 -0.72 0.38 0.62 FALSE
49 GTEx Nerve Tibial LA16c-306E5.3 0.19 0.12 lasso 2 0.10 2.5e-07 -6.7 6.9 6.8e-12 -0.77 0.05 0.95 FALSE
50 GTEx Ovary CLUAP1 0.29 0.14 lasso 3 0.11 1.4e-03 -6.7 -6.8 1.1e-11 0.74 0.04 0.70 FALSE
51 GTEx Ovary NLRC3 0.40 0.11 lasso 7 0.16 9.5e-05 -6.2 6.3 3.1e-10 -0.70 0.08 0.76 FALSE
52 GTEx Pancreas CLUAP1 0.28 0.21 lasso 3 0.24 2.3e-10 -6.7 -6.7 2.0e-11 0.72 0.29 0.70 FALSE
53 GTEx Pituitary CLUAP1 0.32 0.26 lasso 3 0.17 5.6e-05 -6.2 -6.7 2.9e-11 0.65 0.08 0.61 FALSE
54 GTEx Prostate CLUAP1 0.44 0.36 lasso 3 0.35 1.1e-09 -6.7 -6.8 1.3e-11 0.73 0.21 0.71 FALSE
55 GTEx Skin Not Sun Exposed Suprapubic CLUAP1 0.30 0.13 enet 18 0.23 8.1e-13 -6.6 -6.8 1.2e-11 0.70 0.30 0.70 FALSE
56 GTEx Skin Not Sun Exposed Suprapubic NLRC3 0.29 0.16 lasso 6 0.16 6.2e-09 -6.7 6.8 9.9e-12 -0.73 0.30 0.70 FALSE
57 GTEx Skin Sun Exposed Lower leg CLUAP1 0.34 0.25 lasso 6 0.27 1.1e-22 -6.3 -7.1 9.6e-13 0.79 0.87 0.13 FALSE
58 GTEx Skin Sun Exposed Lower leg NLRC3 0.16 0.17 lasso 3 0.18 1.7e-14 -6.6 7.0 3.0e-12 -0.74 0.45 0.55 FALSE
59 GTEx Stomach ZNF500 0.20 0.11 enet 10 0.08 1.5e-04 4.9 5.4 5.7e-08 0.00 0.06 0.92 FALSE
60 GTEx Stomach CLUAP1 0.19 0.10 enet 14 0.14 5.5e-07 -6.2 -6.2 4.8e-10 0.69 0.12 0.85 FALSE
61 GTEx Testis NUDT16L1 0.38 0.49 enet 16 0.38 5.9e-18 5.9 5.5 4.1e-08 -0.02 0.00 1.00 FALSE
62 GTEx Thyroid CLUAP1 0.37 0.17 lasso 6 0.27 1.1e-20 -6.7 -7.2 4.9e-13 0.76 0.39 0.61 FALSE
63 GTEx Thyroid LA16c-306E5.3 0.11 0.15 lasso 1 0.15 1.0e-11 -6.7 6.7 2.6e-11 -0.73 0.36 0.64 FALSE
64 GTEx Uterus MGRN1 0.31 0.13 enet 7 0.05 3.4e-02 5.9 -5.4 6.8e-08 0.02 0.01 0.95 FALSE
65 GTEx Uterus CLUAP1 0.30 0.34 lasso 3 0.31 3.9e-07 -6.6 -6.9 6.2e-12 0.73 0.10 0.73 FALSE
66 GTEx Uterus NLRC3 0.50 0.28 lasso 4 0.29 8.8e-07 -6.7 6.2 4.7e-10 -0.74 0.11 0.49 FALSE
67 GTEx Vagina CLUAP1 0.34 0.23 enet 17 0.26 9.7e-07 -6.7 -6.0 2.1e-09 0.59 0.06 0.86 FALSE
68 GTEx Whole Blood CLUAP1 0.07 0.02 lasso 3 0.01 6.5e-02 -6.7 -6.8 9.8e-12 0.75 0.07 0.62 FALSE
69 The Cancer Genome Atlas Bladder Urothelial Carcinoma NLRC3 0.05 0.01 blup 39 0.02 9.8e-03 -6.7 6.5 6.1e-11 -0.72 0.01 0.90 FALSE
70 The Cancer Genome Atlas Breast Invasive Carcinoma C16orf71 0.01 0.01 blup 52 0.01 3.1e-03 4.9 5.3 1.3e-07 0.01 0.02 0.89 FALSE
71 The Cancer Genome Atlas Breast Invasive Carcinoma CLUAP1 0.03 0.02 enet 5 0.02 3.3e-05 -6.2 -5.7 1.2e-08 0.51 0.02 0.94 FALSE
72 The Cancer Genome Atlas Breast Invasive Carcinoma NLRC3 0.09 0.07 lasso 5 0.10 2.9e-19 -6.7 6.8 1.3e-11 -0.73 0.00 1.00 FALSE
73 The Cancer Genome Atlas Colon Adenocarcinoma NLRC3 0.14 0.04 blup 39 0.10 1.9e-06 -3.8 5.2 2.1e-07 -0.60 0.03 0.90 FALSE
74 The Cancer Genome Atlas Glioblastoma Multiforme NLRC3 0.32 0.11 lasso 5 0.21 4.3e-07 -6.7 5.9 3.1e-09 -0.68 0.00 0.97 FALSE
75 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NLRC3 0.13 0.12 blup 39 0.13 4.9e-14 -6.7 7.0 2.4e-12 -0.67 0.00 1.00 FALSE
76 The Cancer Genome Atlas Brain Lower Grade Glioma CLUAP1 0.03 0.00 blup 42 0.01 2.1e-02 -3.6 -5.3 9.4e-08 0.56 0.01 0.32 FALSE
77 The Cancer Genome Atlas Brain Lower Grade Glioma DNASE1 0.09 0.00 enet 12 0.05 3.4e-06 2.5 -5.9 4.5e-09 0.51 0.00 0.32 FALSE
78 The Cancer Genome Atlas Brain Lower Grade Glioma NLRC3 0.32 0.28 enet 17 0.35 8.2e-41 -6.7 6.0 2.6e-09 -0.69 0.00 1.00 FALSE
79 The Cancer Genome Atlas Liver Hepatocellular Carcinoma NLRC3 0.10 0.04 lasso 2 0.04 6.2e-03 -6.7 7.0 1.9e-12 -0.75 0.01 0.83 FALSE
80 The Cancer Genome Atlas Lung Adenocarcinoma NLRC3 0.09 0.08 enet 3 0.08 3.5e-09 -6.7 6.8 8.1e-12 -0.74 0.00 1.00 FALSE
81 The Cancer Genome Atlas Lung Squamous Cell Carcinoma NLRC3 0.03 0.01 lasso 3 0.00 3.3e-01 -6.3 7.2 4.2e-13 -0.73 0.01 0.83 FALSE
82 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma NLRC3 0.15 0.05 lasso 2 0.11 1.1e-07 -6.7 5.7 1.3e-08 -0.64 0.00 0.98 FALSE
83 The Cancer Genome Atlas Pancreatic Adenocarcinoma NLRC3 0.14 0.11 enet 7 0.14 2.5e-06 -6.7 6.8 1.1e-11 -0.74 0.00 0.98 FALSE
84 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma NLRC3 0.36 0.20 enet 18 0.25 2.9e-10 -6.7 6.2 4.3e-10 -0.63 0.00 1.00 FALSE
85 The Cancer Genome Atlas Prostate Adenocarcinoma NLRC3 0.42 0.25 lasso 6 0.36 1.2e-38 -6.7 6.1 1.2e-09 -0.68 0.00 1.00 FALSE
86 The Cancer Genome Atlas Soft Tissue Sarcoma NLRC3 0.13 0.09 lasso 1 0.09 8.2e-06 -6.7 6.7 2.6e-11 -0.73 0.00 1.00 FALSE
87 The Cancer Genome Atlas Thyroid Carcinoma NLRC3 0.31 0.21 lasso 3 0.26 8.4e-26 -6.7 6.5 9.3e-11 -0.71 0.00 1.00 FALSE
88 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma NLRC3 0.33 0.00 blup 40 0.02 9.3e-02 -6.7 5.5 4.3e-08 -0.63 0.00 0.76 FALSE