[Hub]/) : Traits : Forced vital capacity (FVC) : ← →

chr16:2,510,603-5,510,848

Best TWAS P=1.2e-15 · Best GWAS P=3.88e-14 conditioned to 0.0039

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Adipose Subcutaneous	CLUAP1	0.42	0.32	enet	35	0.35	1.2e-29	-6.7	-8.0	1.2e-15	0.70	0.37	0.63	TRUE
5	GTEx	Adrenal Gland	ZNF500	0.11	0.07	enet	15	0.01	9.6e-02	5.9	6.0	2.5e-09	0.04	0.00	0.96	TRUE
43	GTEx	Muscle Skeletal	ZNF213	0.17	0.00	enet	22	0.03	1.0e-03	-3.8	-5.2	1.8e-07	0.03	0.43	0.02	TRUE
19	GTEx	Brain Hippocampus	CLUAP1	0.37	0.10	lasso	5	0.09	4.9e-03	-7.6	-7.6	3.3e-14	0.89	0.00	0.97	FALSE
7	GTEx	Artery Aorta	CLUAP1	0.40	0.33	enet	18	0.33	5.4e-19	-6.7	-7.5	4.7e-14	0.74	0.37	0.63	FALSE
41	GTEx	Lung	CLUAP1	0.16	0.10	enet	9	0.12	2.1e-09	-6.7	-7.5	7.1e-14	0.81	0.38	0.62	FALSE
37	GTEx	Heart Atrial Appendage	CLUAP1	0.40	0.16	enet	13	0.29	2.3e-13	-6.6	-7.4	1.6e-13	0.79	0.42	0.58	FALSE
30	GTEx	Colon Sigmoid	CLUAP1	0.47	0.32	lasso	9	0.34	1.1e-12	-6.6	-7.3	3.9e-13	0.78	0.42	0.58	FALSE
81	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NLRC3	0.03	0.01	lasso	3	0.00	3.3e-01	-6.3	7.2	4.2e-13	-0.73	0.01	0.83	FALSE
62	GTEx	Thyroid	CLUAP1	0.37	0.17	lasso	6	0.27	1.1e-20	-6.7	-7.2	4.9e-13	0.76	0.39	0.61	FALSE
44	GTEx	Muscle Skeletal	CLUAP1	0.21	0.19	lasso	6	0.20	3.8e-19	-6.7	-7.2	7.2e-13	0.79	0.37	0.63	FALSE
40	GTEx	Heart Left Ventricle	CLUAP1	0.39	0.30	lasso	6	0.34	1.4e-18	-6.7	-7.2	8.6e-13	0.80	0.35	0.65	FALSE
57	GTEx	Skin Sun Exposed Lower leg	CLUAP1	0.34	0.25	lasso	6	0.27	1.1e-22	-6.3	-7.1	9.6e-13	0.79	0.87	0.13	FALSE
38	GTEx	Heart Atrial Appendage	NLRC3	0.27	0.07	lasso	3	0.08	2.2e-04	-6.7	7.1	1.3e-12	-0.80	0.01	0.98	FALSE
32	GTEx	Esophagus Gastroesophageal Junction	CLUAP1	0.58	0.36	lasso	9	0.38	1.5e-14	-6.7	-7.0	1.8e-12	0.73	0.36	0.64	FALSE
79	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	NLRC3	0.10	0.04	lasso	2	0.04	6.2e-03	-6.7	7.0	1.9e-12	-0.75	0.01	0.83	FALSE
14	GTEx	Brain Cerebellum	NLRC3	0.36	0.36	lasso	4	0.36	1.4e-11	-6.7	7.0	2.1e-12	-0.76	0.05	0.95	FALSE
13	GTEx	Brain Cerebellar Hemisphere	NLRC3	0.40	0.39	lasso	2	0.40	2.1e-11	-6.7	7.0	2.2e-12	-0.76	0.03	0.97	FALSE
75	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NLRC3	0.13	0.12	blup	39	0.13	4.9e-14	-6.7	7.0	2.4e-12	-0.67	0.00	1.00	FALSE
47	GTEx	Nerve Tibial	CLUAP1	0.53	0.27	lasso	7	0.42	9.9e-32	-6.7	-7.0	2.6e-12	0.75	0.46	0.54	FALSE
35	GTEx	Esophagus Muscularis	CLUAP1	0.42	0.42	lasso	2	0.44	4.8e-29	-6.7	-7.0	2.8e-12	0.75	0.37	0.63	FALSE
9	GTEx	Artery Tibial	CLUAP1	0.45	0.29	enet	47	0.31	5.2e-25	-6.7	-7.0	3.0e-12	0.66	0.37	0.63	FALSE
58	GTEx	Skin Sun Exposed Lower leg	NLRC3	0.16	0.17	lasso	3	0.18	1.7e-14	-6.6	7.0	3.0e-12	-0.74	0.45	0.55	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CLUAP1	0.26	0.17	enet	24	0.17	2.9e-20	-6.7	-7.0	3.4e-12	0.66	0.37	0.63	FALSE
42	GTEx	Lung	ZSCAN32	0.08	0.02	lasso	3	0.02	6.3e-03	-6.3	-6.9	3.8e-12	0.58	0.09	0.25	FALSE
34	GTEx	Esophagus Mucosa	CLUAP1	0.30	0.18	lasso	7	0.19	1.3e-12	-6.7	-6.9	6.0e-12	0.75	0.42	0.58	FALSE
65	GTEx	Uterus	CLUAP1	0.30	0.34	lasso	3	0.31	3.9e-07	-6.6	-6.9	6.2e-12	0.73	0.10	0.73	FALSE
49	GTEx	Nerve Tibial	LA16c-306E5.3	0.19	0.12	lasso	2	0.10	2.5e-07	-6.7	6.9	6.8e-12	-0.77	0.05	0.95	FALSE
80	The Cancer Genome Atlas	Lung Adenocarcinoma	NLRC3	0.09	0.08	enet	3	0.08	3.5e-09	-6.7	6.8	8.1e-12	-0.74	0.00	1.00	FALSE
68	GTEx	Whole Blood	CLUAP1	0.07	0.02	lasso	3	0.01	6.5e-02	-6.7	-6.8	9.8e-12	0.75	0.07	0.62	FALSE
33	GTEx	Esophagus Gastroesophageal Junction	NLRC3	0.29	0.16	lasso	3	0.18	5.1e-07	-6.7	6.8	9.9e-12	-0.75	0.10	0.87	FALSE
56	GTEx	Skin Not Sun Exposed Suprapubic	NLRC3	0.29	0.16	lasso	6	0.16	6.2e-09	-6.7	6.8	9.9e-12	-0.73	0.30	0.70	FALSE
50	GTEx	Ovary	CLUAP1	0.29	0.14	lasso	3	0.11	1.4e-03	-6.7	-6.8	1.1e-11	0.74	0.04	0.70	FALSE
83	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NLRC3	0.14	0.11	enet	7	0.14	2.5e-06	-6.7	6.8	1.1e-11	-0.74	0.00	0.98	FALSE
55	GTEx	Skin Not Sun Exposed Suprapubic	CLUAP1	0.30	0.13	enet	18	0.23	8.1e-13	-6.6	-6.8	1.2e-11	0.70	0.30	0.70	FALSE
54	GTEx	Prostate	CLUAP1	0.44	0.36	lasso	3	0.35	1.1e-09	-6.7	-6.8	1.3e-11	0.73	0.21	0.71	FALSE
72	The Cancer Genome Atlas	Breast Invasive Carcinoma	NLRC3	0.09	0.07	lasso	5	0.10	2.9e-19	-6.7	6.8	1.3e-11	-0.73	0.00	1.00	FALSE
15	GTEx	Brain Cerebellum	SLX4	0.33	0.14	lasso	3	0.10	6.8e-04	-6.3	6.7	1.8e-11	-0.75	0.03	0.82	FALSE
26	GTEx	Breast Mammary Tissue	CLUAP1	0.26	0.13	lasso	8	0.13	4.6e-07	-6.7	-6.7	1.9e-11	0.79	0.29	0.71	FALSE
52	GTEx	Pancreas	CLUAP1	0.28	0.21	lasso	3	0.24	2.3e-10	-6.7	-6.7	2.0e-11	0.72	0.29	0.70	FALSE
22	GTEx	Brain Hypothalamus	NLRC3	0.38	0.15	lasso	6	0.17	8.3e-05	-6.7	6.7	2.1e-11	-0.74	0.06	0.64	FALSE
45	GTEx	Muscle Skeletal	NLRC3	0.16	0.11	lasso	2	0.11	7.9e-11	-6.7	6.7	2.3e-11	-0.74	0.37	0.63	FALSE
17	GTEx	Brain Cortex	NLRC3	0.30	0.34	lasso	1	0.31	2.3e-09	-6.7	6.7	2.6e-11	-0.73	0.07	0.92	FALSE
63	GTEx	Thyroid	LA16c-306E5.3	0.11	0.15	lasso	1	0.15	1.0e-11	-6.7	6.7	2.6e-11	-0.73	0.36	0.64	FALSE
86	The Cancer Genome Atlas	Soft Tissue Sarcoma	NLRC3	0.13	0.09	lasso	1	0.09	8.2e-06	-6.7	6.7	2.6e-11	-0.73	0.00	1.00	FALSE
53	GTEx	Pituitary	CLUAP1	0.32	0.26	lasso	3	0.17	5.6e-05	-6.2	-6.7	2.9e-11	0.65	0.08	0.61	FALSE
21	GTEx	Brain Hypothalamus	CLUAP1	0.47	0.31	lasso	8	0.32	3.3e-08	-6.7	-6.6	3.1e-11	0.73	0.06	0.77	FALSE
11	GTEx	Brain Caudate basal ganglia	NLRC3	0.41	0.11	lasso	4	0.24	2.0e-07	-6.7	6.6	4.9e-11	-0.71	0.16	0.65	FALSE
69	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NLRC3	0.05	0.01	blup	39	0.02	9.8e-03	-6.7	6.5	6.1e-11	-0.72	0.01	0.90	FALSE
36	GTEx	Esophagus Muscularis	NLRC3	0.48	0.29	lasso	6	0.36	5.1e-23	-6.7	6.5	6.9e-11	-0.71	0.38	0.62	FALSE
48	GTEx	Nerve Tibial	NLRC3	0.29	0.24	lasso	3	0.32	8.7e-23	-6.7	6.5	8.5e-11	-0.72	0.38	0.62	FALSE
87	The Cancer Genome Atlas	Thyroid Carcinoma	NLRC3	0.31	0.21	lasso	3	0.26	8.4e-26	-6.7	6.5	9.3e-11	-0.71	0.00	1.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NLRC3	0.44	0.40	lasso	3	0.40	9.3e-53	-6.7	6.5	1.0e-10	-0.73	0.37	0.63	FALSE
29	GTEx	Cells Transformed fibroblasts	CLUAP1	0.56	0.35	lasso	10	0.39	1.7e-30	-6.7	-6.4	1.7e-10	0.69	0.37	0.63	FALSE
51	GTEx	Ovary	NLRC3	0.40	0.11	lasso	7	0.16	9.5e-05	-6.2	6.3	3.1e-10	-0.70	0.08	0.76	FALSE
8	GTEx	Artery Coronary	CLUAP1	0.31	0.26	enet	13	0.25	6.8e-09	-6.7	-6.3	3.2e-10	0.74	0.11	0.87	FALSE
20	GTEx	Brain Hippocampus	NLRC3	0.49	0.28	lasso	5	0.34	8.0e-09	-6.7	6.3	3.6e-10	-0.65	0.03	0.84	FALSE
84	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	NLRC3	0.36	0.20	enet	18	0.25	2.9e-10	-6.7	6.2	4.3e-10	-0.63	0.00	1.00	FALSE
66	GTEx	Uterus	NLRC3	0.50	0.28	lasso	4	0.29	8.8e-07	-6.7	6.2	4.7e-10	-0.74	0.11	0.49	FALSE
60	GTEx	Stomach	CLUAP1	0.19	0.10	enet	14	0.14	5.5e-07	-6.2	-6.2	4.8e-10	0.69	0.12	0.85	FALSE
24	GTEx	Brain Nucleus accumbens basal ganglia	NLRC3	0.24	0.14	enet	6	0.22	1.1e-06	-6.7	6.2	5.3e-10	-0.69	0.04	0.88	FALSE
27	GTEx	Breast Mammary Tissue (Female)	CLUAP1	0.35	0.14	lasso	8	0.12	2.3e-04	-6.7	-6.2	7.4e-10	0.69	0.10	0.67	FALSE
4	GTEx	Adipose Visceral Omentum	CLUAP1	0.25	0.17	enet	16	0.16	7.7e-09	-6.7	-6.1	1.2e-09	0.69	0.21	0.78	FALSE
85	The Cancer Genome Atlas	Prostate Adenocarcinoma	NLRC3	0.42	0.25	lasso	6	0.36	1.2e-38	-6.7	6.1	1.2e-09	-0.68	0.00	1.00	FALSE
6	GTEx	Adrenal Gland	NLRC3	0.28	0.06	lasso	3	0.02	6.0e-02	-6.6	6.1	1.4e-09	-0.66	0.05	0.31	FALSE
31	GTEx	Colon Transverse	CLUAP1	0.25	0.09	lasso	3	0.14	2.0e-07	-6.7	-6.0	1.6e-09	0.67	0.14	0.85	FALSE
67	GTEx	Vagina	CLUAP1	0.34	0.23	enet	17	0.26	9.7e-07	-6.7	-6.0	2.1e-09	0.59	0.06	0.86	FALSE
78	The Cancer Genome Atlas	Brain Lower Grade Glioma	NLRC3	0.32	0.28	enet	17	0.35	8.2e-41	-6.7	6.0	2.6e-09	-0.69	0.00	1.00	FALSE
74	The Cancer Genome Atlas	Glioblastoma Multiforme	NLRC3	0.32	0.11	lasso	5	0.21	4.3e-07	-6.7	5.9	3.1e-09	-0.68	0.00	0.97	FALSE
39	GTEx	Heart Atrial Appendage	NUDT16L1	0.12	0.17	lasso	1	0.17	4.8e-08	5.9	-5.9	4.2e-09	0.02	0.00	1.00	FALSE
77	The Cancer Genome Atlas	Brain Lower Grade Glioma	DNASE1	0.09	0.00	enet	12	0.05	3.4e-06	2.5	-5.9	4.5e-09	0.51	0.00	0.32	FALSE
10	GTEx	Artery Tibial	NLRC3	0.39	0.26	lasso	7	0.36	1.5e-29	-6.7	5.9	4.9e-09	-0.67	0.37	0.63	FALSE
18	GTEx	Brain Frontal Cortex BA9	NLRC3	0.50	0.18	enet	30	0.33	1.6e-09	-6.6	5.8	7.9e-09	-0.70	0.01	0.99	FALSE
71	The Cancer Genome Atlas	Breast Invasive Carcinoma	CLUAP1	0.03	0.02	enet	5	0.02	3.3e-05	-6.2	-5.7	1.2e-08	0.51	0.02	0.94	FALSE
82	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	NLRC3	0.15	0.05	lasso	2	0.11	1.1e-07	-6.7	5.7	1.3e-08	-0.64	0.00	0.98	FALSE
46	GTEx	Muscle Skeletal	AC006111.1	0.29	0.07	enet	22	0.20	2.2e-19	2.5	-5.5	3.3e-08	0.57	0.24	0.76	FALSE
25	GTEx	Breast Mammary Tissue	ZNF500	0.18	0.10	lasso	3	0.10	5.0e-06	5.9	5.5	4.1e-08	-0.02	0.00	1.00	FALSE
61	GTEx	Testis	NUDT16L1	0.38	0.49	enet	16	0.38	5.9e-18	5.9	5.5	4.1e-08	-0.02	0.00	1.00	FALSE
88	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	NLRC3	0.33	0.00	blup	40	0.02	9.3e-02	-6.7	5.5	4.3e-08	-0.63	0.00	0.76	FALSE
59	GTEx	Stomach	ZNF500	0.20	0.11	enet	10	0.08	1.5e-04	4.9	5.4	5.7e-08	0.00	0.06	0.92	FALSE
16	GTEx	Brain Cortex	ZNF500	0.18	0.02	enet	8	0.04	2.5e-02	-4.0	5.4	6.5e-08	0.05	0.04	0.50	FALSE
64	GTEx	Uterus	MGRN1	0.31	0.13	enet	7	0.05	3.4e-02	5.9	-5.4	6.8e-08	0.02	0.01	0.95	FALSE
23	GTEx	Brain Nucleus accumbens basal ganglia	MGRN1	0.39	0.25	lasso	5	0.26	1.4e-07	5.2	-5.4	8.7e-08	0.01	0.01	0.99	FALSE
76	The Cancer Genome Atlas	Brain Lower Grade Glioma	CLUAP1	0.03	0.00	blup	42	0.01	2.1e-02	-3.6	-5.3	9.4e-08	0.56	0.01	0.32	FALSE
12	GTEx	Brain Cerebellar Hemisphere	ZNF500	0.27	0.13	enet	13	0.12	4.4e-04	4.1	5.3	9.7e-08	0.03	0.05	0.86	FALSE
70	The Cancer Genome Atlas	Breast Invasive Carcinoma	C16orf71	0.01	0.01	blup	52	0.01	3.1e-03	4.9	5.3	1.3e-07	0.01	0.02	0.89	FALSE
28	GTEx	Cells Transformed fibroblasts	ZNF500	0.17	0.12	enet	19	0.16	3.0e-12	4.4	5.2	1.8e-07	0.02	0.23	0.76	FALSE
73	The Cancer Genome Atlas	Colon Adenocarcinoma	NLRC3	0.14	0.04	blup	39	0.10	1.9e-06	-3.8	5.2	2.1e-07	-0.60	0.03	0.90	FALSE