Hub : Genes

HAGHL

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1560	0.0500	2.0e-03	0.042	NA	0.005	NA	0.018	2.2e-04	NA	1.1e-01	NA	1.2e-02
2	GTEx	Brain Cerebellar Hemisphere	0.2420	0.0940	3.6e-03	0.029	NA	0.038	NA	0.060	6.1e-02	NA	3.8e-02	NA	1.2e-02
3	GTEx	Heart Left Ventricle	0.2500	0.0753	4.8e-05	0.150	NA	0.084	NA	0.118	2.1e-08	NA	3.1e-05	NA	7.8e-07
4	GTEx	Testis	0.2700	0.0740	6.4e-05	0.161	NA	0.157	NA	0.163	1.3e-07	NA	1.9e-07	NA	1.0e-07
5	METSIM	Adipose	0.0988	0.0304	1.3e-05	0.065	0.046	0.062	NA	0.065	4.6e-10	1.5e-07	1.4e-09	NA	5.6e-10
6	TCGA	Colon Adenocarcinoma	0.0500	0.0290	4.9e-03	0.018	0.037	0.026	NA	0.031	3.2e-02	3.1e-03	1.1e-02	NA	6.6e-03
7	TCGA	Head and Neck Squamous Cell Carcinoma	0.0697	0.0517	9.4e-04	0.016	0.026	0.044	NA	0.006	5.3e-03	6.0e-04	1.1e-05	NA	5.5e-02
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0289	0.0149	7.4e-04	0.036	0.025	0.035	NA	0.030	6.1e-05	7.0e-04	6.6e-05	NA	2.5e-04
9	TCGA	Brain Lower Grade Glioma	0.0572	0.0288	4.7e-03	0.002	0.018	0.001	NA	0.001	1.6e-01	3.8e-03	2.1e-01	NA	2.6e-01
10	TCGA	Lung Squamous Cell Carcinoma	0.0224	0.0119	2.5e-03	0.004	0.015	0.000	NA	0.002	1.2e-01	7.0e-03	2.7e-01	NA	1.8e-01
11	TCGA	Prostate Adenocarcinoma	0.0321	0.0178	4.4e-03	0.006	0.011	0.003	NA	0.010	7.0e-02	2.2e-02	1.5e-01	NA	2.5e-02
12	TCGA	Thyroid Carcinoma	0.0680	0.0310	3.7e-05	0.044	0.043	0.024	NA	0.035	3.8e-05	4.2e-05	2.0e-03	NA	2.0e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.2	0.3	1.1	0.0	-1.1	0.9	-1.0	0.8	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder or Schizophrenia	0.4	1.1	8.8	0.0	-3.0	1.3	-1.1	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Depressed Affect (Nagel 2018)	1.3	2.8	6.6	-0.2	0.8	-1.9	2.2	-1.9	-2.0	-1.1	-2.6	0.0	-1.6	-1.3	-2.0
Depression (Nagel 2018)	0.4	0.6	1.7	-0.5	1.3	-0.6	0.4	-0.6	-0.8	0.5	-1.2	-0.2	-0.8	-0.4	-0.9
Intelligence (Savage-Jansen 2018)	0.4	1.2	6.1	0.5	0.7	0.9	-0.8	1.5	0.1	0.2	0.5	0.2	0.1	2.5	1.9
Neuroticism (Nagel 2018)	0.4	0.9	2.1	-0.4	-0.8	-1.3	1.4	-1.0	-1.1	-0.7	-1.2	0.1	-1.2	0.0	-0.9
Schizophrenia (2018)	0.4	0.9	8.7	0.0	-3.0	0.9	-0.7	0.6	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Worry (Nagel 2018)	0.6	1.3	7.0	1.2	-2.6	0.5	-0.4	0.8	0.6	0.6	0.5	1.1	0.3	1.8	0.6
Alzheimer’s Disease (in mother)	0.5	0.6	2.1	-1.5	0.7	-0.5	0.6	-0.4	-1.1	0.1	-0.8	-0.1	-1.2	-0.3	0.2
Alzheimer’s Disease (in father)	0.6	0.7	3.8	0.2	1.9	0.2	0.0	0.5	-0.6	-0.7	-0.6	1.4	-0.6	0.1	0.5
Alzheimer’s Disease (including proxy)	0.7	1.1	2.4	-1.3	1.5	-0.6	0.8	-0.5	-1.5	-0.4	-1.3	0.6	-1.6	-1.0	-0.0
Crohns Disease (2017)	0.6	1.4	2.4	0.8	-1.0	1.4	-1.3	1.4	1.6	0.7	1.5	1.3	1.1	0.8	1.1
Irritable Bowel Disease (IBD)	0.9	2.0	4.1	0.9	-1.0	1.6	-1.6	1.8	1.6	0.8	1.3	2.0	1.1	1.4	1.5
Ulcerative Colitis (UC)	0.4	0.7	2.9	0.6	-0.1	0.8	-1.0	1.1	0.5	0.5	0.3	1.7	0.2	1.1	0.9
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	1.6	3.1	5.8	1.0	-1.0	1.9	-1.8	2.1	2.0	1.5	2.1	1.0	1.9	2.4	1.4
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.9	1.2	0.5	0.6	-0.4	0.9	0.5	1.4	0.1	-0.6	0.7	1.7	1.2
Breast Cancer	1.7	4.2	7.4	-2.7	2.7	-2.0	2.2	-1.9	-2.4	-0.5	-1.7	-1.9	-2.4	-1.5	-1.5
Ovarian Cancer	0.4	0.6	1.9	-0.7	-0.7	-0.4	0.6	-0.7	0.5	1.4	0.5	-0.2	0.7	-1.0	-1.0
Prostate Cancer	0.9	1.2	4.2	1.1	-2.0	0.6	-0.9	0.6	1.4	0.0	1.7	0.7	1.4	0.5	0.5
Age at First Birth	3.8	5.5	8.9	1.7	-1.9	2.6	-2.7	2.6	2.9	1.7	2.2	0.3	2.8	3.0	2.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.2	2.4	0.0	0.0	0.0	0.0	-1.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.3	0.4	3.1	0.0	-1.5	1.7	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Mean Putamen Volume	0.8	1.0	2.7	0.6	1.6	-0.5	0.5	-0.3	-1.3	-1.5	-1.2	0.4	-1.5	0.1	0.5
Fasting Glucose	0.9	1.0	3.2	-1.0	1.8	-1.0	0.9	-1.1	-0.8	0.3	-0.4	-1.3	-0.8	-0.9	-1.1
HbA1C	1.3	1.4	2.7	-0.4	1.6	-1.4	1.4	-1.4	-1.6	-0.4	-1.2	0.1	-1.6	-1.3	-0.2
HDL Cholesterol	1.3	2.2	9.4	0.0	-0.5	2.8	-3.1	2.9	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.3	0.4	2.0	0.0	1.4	-1.2	0.8	-1.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Lupus	0.1	0.2	1.7	-0.2	0.4	0.0	-0.5	0.0	0.2	1.3	0.1	-0.3	0.0	0.0	-0.2
Neuroticism (2016)	0.8	1.1	2.7	0.0	-0.6	-1.6	1.1	-1.6	-0.8	-0.6	-1.3	-1.2	-1.0	-0.3	-1.1
Primary Biliary Cirrhosis	0.2	0.3	2.7	-0.0	-0.3	-0.1	0.3	-0.1	-0.2	0.5	0.1	1.6	0.2	-0.2	0.5
Rheumatoid Arthritis	0.6	0.8	1.5	0.0	0.1	1.1	-0.6	1.1	1.1	0.0	0.9	1.2	1.2	0.9	1.0
Schizophrenia (2014)	0.7	1.5	9.6	0.0	-3.1	1.9	-1.6	1.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.1	0.1	0.4	0.0	-0.2	-0.6	0.4	-0.6	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.1	0.1	0.4	0.0	-0.6	0.5	-0.4	0.6	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Eosinophil Count	2.4	18.1	23.9	4.7	-3.4	4.9	-4.8	4.8	4.3	2.1	4.5	3.7	4.4	4.4	4.4
Blood Platelet Count	3.1	35.4	52.4	-5.0	6.8	-6.0	6.3	-5.6	-7.2	-5.5	-7.0	-2.4	-7.2	-6.1	-4.6
Blood Red Count	0.3	3.2	19.1	0.4	-4.4	-0.4	-0.1	-0.9	2.2	0.8	0.7	0.1	2.9	-0.8	-1.7
Blood White Count	0.3	2.0	5.3	-1.3	1.2	-1.1	0.8	-1.2	-1.7	-1.3	-1.1	-1.2	-1.9	-2.3	-1.2
Heel T-Score	0.3	2.2	5.2	-2.3	0.9	-1.4	0.8	-1.4	-1.5	-1.7	-0.9	-0.5	-1.9	-2.3	-1.2
BMI	0.2	0.9	4.6	-0.3	0.6	-0.6	0.7	-0.5	-0.7	-2.1	-0.6	-0.8	-0.6	-1.4	-1.2
Height	12.9	248.0	368.6	14.5	-14.3	17.7	-17.4	16.5	19.2	10.7	16.1	11.7	18.6	14.2	15.7
Waist Hip Ratio (WHR)	0.2	1.0	3.8	-0.1	-0.1	-0.7	0.8	-1.1	-0.4	0.4	-0.5	-1.9	-0.2	-1.7	-1.5
Systolic Blood Pressure	0.9	4.3	7.9	1.1	-1.4	2.7	-2.8	2.3	2.6	2.0	2.7	0.1	2.2	1.3	1.8
Smoking Status	3.4	8.1	13.9	-2.0	3.0	-2.5	2.9	-2.3	-3.7	-2.8	-3.0	0.3	-3.7	-3.7	-2.4
Allergy or Eczema	0.7	1.8	8.6	-0.9	2.9	-0.8	1.0	-0.4	-1.9	-1.0	-1.4	-0.2	-1.8	-0.3	-0.4
Cardiovascular Disease	1.1	3.5	6.2	2.0	-2.0	2.2	-2.4	2.0	2.5	0.4	1.7	0.3	2.2	1.6	1.6
Hypothyroidism (self reported)	0.5	1.2	6.6	0.8	2.6	-0.2	0.3	0.4	-1.1	-1.3	-1.2	0.2	-1.0	1.2	0.3
Respiratory disease	1.3	2.8	18.0	-0.0	4.2	-1.1	1.2	-0.5	-2.2	-1.4	-1.6	0.2	-1.6	-0.5	-0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	0.7	0.1	-0.3	0.5	-0.3	-0.5	-0.3	-0.8	-0.2	-0.5	-0.2	-0.1
Lung FEV1/FVC ratio	0.2	0.9	3.6	-0.7	-1.9	-1.1	0.5	-1.4	-0.4	-0.4	-0.9	0.2	-0.6	-1.1	-0.7
Lung FVC	0.5	2.4	8.4	-1.2	2.9	-0.5	0.6	0.1	-2.3	-1.7	-1.1	1.4	-2.5	-0.1	0.9
Neuroticism	1.0	2.4	4.2	-1.5	-0.9	-1.9	2.0	-1.9	-1.6	-0.2	-1.9	-1.1	-1.5	-0.8	-2.1
Chronotype (morning person)	0.9	2.0	7.2	-0.6	-2.7	-1.1	1.3	-1.6	0.7	0.1	0.7	-1.7	1.1	-2.0	-1.4
Hair Pigment	0.0	1.3	7.6	-0.0	-1.4	0.4	-0.8	0.3	1.4	2.8	0.9	-0.7	1.1	0.6	-0.6
Tanning	0.3	3.7	8.2	2.1	-2.6	1.9	-1.5	1.0	2.9	1.6	2.0	1.6	2.6	-0.5	1.2
Hand grip strength (left)	1.1	2.9	5.4	1.4	-0.1	2.1	-2.3	2.2	1.4	0.5	1.6	1.9	1.4	1.8	2.2
Number of treatments/medications taken	0.2	0.4	1.5	0.5	0.6	0.5	-0.7	0.8	-0.4	-0.4	-0.0	1.2	-0.2	0.5	0.6
Average weekly spirits intake	1.2	1.4	4.5	0.1	-1.1	1.2	-1.1	1.4	1.2	1.3	1.2	0.4	1.2	2.1	0.9
Sensitivity / hurt feelings	0.9	1.5	7.0	0.8	-2.6	0.6	-0.8	0.6	1.3	1.3	1.4	-0.1	1.1	1.3	1.1
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.7	-1.6	0.7	-1.0	0.7	-0.8	-1.0	0.6	-0.6	-1.1	-0.9	-0.1	-0.9
Hearing difficulty/problems: Yes	1.6	2.4	5.4	-0.7	-0.1	-2.1	2.3	-2.2	-1.5	-1.0	-1.5	-1.5	-1.3	-1.7	-1.4
Relative age of first facial hair	0.7	1.3	2.9	0.5	-1.2	1.3	-0.9	1.1	1.7	0.8	1.7	0.9	1.4	0.6	1.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.7	0.7	0.8	0.2	0.2	0.5	-0.2	-0.7	-0.7	1.3	-0.1	0.8	0.9
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.5	0.9	0.7	0.6	-0.7	0.6	0.1	-0.4	0.2	1.2	0.1	0.5	1.6
Ever had hysterectomy (womb removed)	0.5	0.6	1.7	-0.2	-0.8	-0.8	1.0	-1.0	-0.1	0.3	-0.1	-1.3	-0.0	-0.6	-1.1
Systolic blood pressure, automated reading	1.0	2.8	6.7	0.6	-1.1	2.3	-2.6	1.9	2.2	0.7	2.2	0.4	1.8	0.2	1.4
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	3.0	1.0	-0.6	1.6	-1.5	1.7	0.7	1.3	0.8	1.5	0.9	1.7	1.5
Angina	0.1	0.2	0.5	0.6	-0.6	-0.1	0.1	-0.3	0.6	0.7	0.4	-0.3	0.2	-0.1	0.2
Medication for hormone replacement therapy	0.5	0.6	1.7	0.0	-0.3	1.0	-0.6	0.9	0.9	0.9	1.0	1.3	0.7	0.0	0.5
Vitamin and mineral supplements	0.7	1.0	3.1	0.3	0.1	-0.8	1.2	-1.0	-0.8	-1.0	-0.9	-0.9	-1.2	-1.8	-0.6
Supplements: Zinc	0.8	0.8	2.8	0.7	1.7	1.1	-0.9	1.4	-0.1	-0.3	0.3	0.8	-0.2	1.1	0.8
Medication: Co-codamol	0.7	0.8	1.8	0.1	0.2	-1.2	1.4	-1.1	-0.8	-0.5	-1.3	-0.3	-0.7	-1.3	-0.9
Medication: Metformin	0.1	0.2	0.9	0.6	-0.9	-0.1	0.2	-0.2	0.1	-0.5	-0.2	-0.5	-0.0	-0.3	-0.0
Diabetes (father)	1.4	1.7	5.2	-0.9	2.3	-1.1	0.9	-0.9	-1.2	-0.8	-2.1	0.6	-1.3	-0.7	-1.5
Diabetes (mother)	1.2	1.5	4.8	2.2	-0.1	1.1	-0.9	1.4	0.6	-1.5	1.2	0.6	0.6	1.4	1.6
Severe depression (siblings)	3.7	4.2	9.7	-1.4	3.1	-2.1	1.9	-1.8	-2.5	-0.9	-3.1	-0.9	-2.3	-1.3	-1.6
Pack years adult smoking proportion	0.2	0.3	2.1	1.0	-0.2	-0.0	0.3	-0.2	0.1	-1.4	-0.1	0.4	0.2	-0.6	0.2
Impedance of leg (right)	0.7	3.4	9.4	-1.0	-0.1	-2.4	3.1	-2.6	-1.7	-0.8	-1.3	-0.5	-1.3	-2.8	-1.9
Leg fat-free mass (left)	6.6	35.0	52.0	5.3	-4.4	7.2	-7.2	7.0	7.2	3.1	5.9	3.9	6.7	5.7	5.7
Trunk fat percentage	0.2	0.8	1.8	0.4	-1.0	1.3	-0.7	1.3	1.3	-0.4	1.0	0.9	1.1	-0.4	0.2
Hand grip strength (right)	0.7	1.8	3.4	1.1	0.1	1.6	-1.8	1.8	0.8	-0.3	1.3	1.6	0.8	1.6	1.8
Townsend deprivation index at recruitment	2.6	3.7	5.9	-1.0	2.3	-2.0	2.0	-2.0	-2.4	-1.0	-2.4	-0.6	-2.2	-2.2	-1.9
Current tobacco smoking	0.8	1.4	3.5	0.9	1.4	-0.5	0.7	-0.4	-1.2	-1.7	-1.1	1.9	-1.3	-1.3	-0.1
Average weekly fortified wine intake	0.4	0.5	2.1	-1.5	-0.4	-0.5	0.6	-0.4	-0.8	-0.8	-0.0	0.0	-1.2	-0.0	0.3
Maternal smoking around birth	1.4	2.0	6.0	-1.8	2.5	-1.1	1.0	-1.0	-1.6	-0.9	-1.3	-0.9	-1.8	-1.2	-1.1
Fed-up feelings	2.6	4.8	7.2	-1.7	1.6	-2.5	2.6	-2.4	-2.7	-1.2	-2.6	-1.0	-2.5	-1.8	-2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	2.7	-1.1	1.6	-0.5	0.3	-0.1	-1.4	0.3	-0.9	0.0	-1.1	0.2	-0.7
Relative age voice broke	0.5	0.7	2.8	1.2	-1.7	0.5	-0.5	0.4	1.0	0.4	1.1	0.7	1.0	0.2	0.4
Taking other prescription medications	0.4	0.6	1.9	0.9	0.5	1.0	-0.9	1.2	0.3	-0.8	0.1	1.4	0.1	0.5	0.8
Age when periods started (menarche)	1.4	3.3	7.8	-1.4	2.5	-2.0	1.9	-1.5	-2.8	-1.5	-2.2	-0.1	-2.5	-0.6	-0.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	1.4	0.4	-1.2	0.2	-0.3	0.1	0.4	-0.1	0.1	0.7	0.3	0.5	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.0	-0.4	0.6	-0.6	0.5	-0.6	-0.6	-1.0	-0.3	-0.3	-0.6	-0.8	-0.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.0	0.9	-1.0	0.5	-0.3	0.5	0.4	0.3	0.3	0.7	0.6	1.0	0.9
Qualifications: CSEs or equivalent	1.5	2.0	3.1	-1.6	1.3	-1.5	1.7	-1.6	-1.1	-0.5	-1.5	-1.8	-1.3	-1.2	-1.6
Serious illness, injury or assault to yourself	0.2	0.3	2.3	-0.1	0.8	0.0	-0.0	0.2	-0.1	0.4	-0.1	1.5	-0.2	0.2	-0.2
High blood pressure	1.8	4.9	8.5	2.5	-2.2	2.4	-2.8	2.2	2.9	0.8	1.8	0.1	2.8	2.2	1.9
Hayfever, allergic rhinitis or eczema	0.4	0.8	5.5	-0.6	2.4	0.2	0.0	0.6	-1.0	-0.8	-0.5	0.2	-1.1	0.7	0.3
Multivitamins +/- minerals	0.7	0.9	4.1	0.2	-0.6	0.4	-0.5	0.5	0.8	2.0	0.4	0.8	1.4	1.1	-0.3
Stomach or abdominal pain in last month	0.4	0.5	2.0	1.2	1.4	-0.2	0.4	-0.1	-0.5	-0.2	-0.6	1.2	-0.4	-0.1	0.4
Supplements: Glucosamine	0.5	0.6	3.6	-0.3	1.9	-0.3	0.3	-0.0	-1.2	-0.3	-0.9	-0.1	-1.0	0.3	-0.1
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	3.6	1.6	0.4	0.7	-0.3	0.9	0.6	-1.0	0.5	1.9	1.1	1.1	1.5
Medication: Atenolol	0.5	0.6	2.0	0.3	-1.4	0.6	-0.6	0.2	1.1	0.3	1.4	-0.6	0.8	-0.5	0.4
Medication: Levothyroxine sodium	0.3	0.4	2.1	-0.0	1.4	0.5	-0.2	0.8	-0.2	-0.6	-0.1	1.0	-0.4	0.6	0.6
Sitting height	10.4	73.7	98.8	7.8	-7.3	9.6	-9.4	9.3	9.9	5.3	8.9	6.8	9.8	8.5	9.1
Chronic bronchitis/emphysema (father)	0.2	0.2	0.8	-0.5	0.4	-0.2	0.4	0.1	-0.9	-0.0	-0.5	-0.4	-0.9	-0.0	-0.1
High blood pressure (mother)	0.6	0.8	2.6	0.2	0.0	-1.2	1.1	-1.4	0.1	-0.2	-1.0	-1.6	0.3	-0.5	-0.9
Body mass index (BMI)	0.2	0.7	2.6	-0.9	0.7	-0.1	0.1	-0.2	-0.1	-1.6	-0.5	-0.6	-0.4	-1.6	-1.2
Impedance of leg (left)	0.7	3.6	9.5	-1.1	0.0	-2.4	3.1	-2.6	-1.9	-0.7	-1.5	-0.4	-1.5	-2.6	-2.0
Leg predicted mass (left)	6.6	35.1	52.1	5.3	-4.4	7.2	-7.2	7.0	7.2	3.1	5.9	3.9	6.7	5.7	5.7
Trunk fat mass	1.6	7.0	12.9	2.2	-2.5	3.4	-2.9	3.2	3.6	0.8	2.8	2.1	3.3	1.4	2.0
Waist circumference	1.1	4.0	7.8	1.9	-1.3	2.7	-2.4	2.4	2.8	0.2	2.2	0.8	2.6	0.8	1.5
Number of incorrect matches in round	4.8	8.0	13.0	2.4	-3.4	3.0	-2.9	2.6	3.6	1.7	3.0	1.9	3.3	2.4	3.1
Past tobacco smoking	5.9	10.8	17.6	3.9	-3.1	3.2	-3.5	2.9	4.2	1.4	3.0	2.5	4.0	3.4	3.5
Alcohol usually taken with meals	0.9	1.5	4.4	1.5	-1.7	0.5	-0.7	0.3	1.8	2.1	1.1	-0.0	1.5	0.6	0.5
Nervous feelings	0.4	0.8	5.5	0.7	-2.3	0.3	-0.5	0.4	0.5	1.1	0.7	0.1	0.2	1.0	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.2	-0.1	-0.7	0.3	-0.4	0.6	0.0	0.4	0.3	1.5	0.1	1.4	0.3
Hearing difficulty/problems with background noise	3.1	5.0	9.1	-1.2	0.8	-3.0	2.7	-2.9	-2.5	-1.1	-2.3	-2.1	-2.5	-2.0	-2.4
Hair/balding pattern: Pattern 2	0.7	0.9	2.7	1.0	-1.7	0.8	-0.6	0.5	1.5	0.6	1.0	-0.6	1.3	0.3	0.4
Had menopause	0.2	0.2	0.7	0.3	-0.7	0.2	-0.5	0.0	0.7	0.8	0.2	0.2	0.7	0.3	0.6
Had other major operations	0.5	0.7	1.9	-0.1	1.4	-0.4	0.3	-0.1	-1.3	-0.1	-0.8	1.3	-1.2	0.6	0.4
Forced vital capacity (FVC)	5.1	19.5	28.9	3.6	-2.8	5.1	-4.8	5.4	4.2	2.9	4.3	4.4	4.1	5.3	5.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.6	-0.7	0.8	-0.5	0.5	-0.4	-0.7	-1.3	-0.0	-0.1	-0.9	-1.0	-0.4
Ever unenthusiastic/disinterested for a whole week	2.1	2.5	7.5	1.3	-1.2	1.6	-1.7	1.8	1.1	0.4	1.3	2.7	1.0	1.7	1.9
Qualifications: None of the above	4.9	10.6	25.6	-2.1	2.5	-3.2	3.4	-3.6	-3.3	-2.7	-3.1	-2.4	-3.1	-5.1	-3.7
Financial difficulties in last 2 years	0.7	0.9	6.7	1.0	0.3	-0.6	0.6	-0.7	-0.5	-2.6	-0.6	-0.2	-0.7	-0.6	-0.1
Mouth/teeth dental problems	0.4	0.7	2.3	-0.1	-0.4	0.7	-0.5	0.6	1.0	0.8	1.5	-0.8	1.1	0.7	0.5
Heart attack	1.6	2.0	3.8	-0.9	1.2	-1.9	1.6	-1.9	-1.4	-0.1	-1.8	-0.9	-1.6	-1.3	-1.2
Allergy	0.7	1.6	10.0	0.1	-3.2	0.1	-0.4	-0.6	1.4	1.4	0.9	-1.0	1.3	-0.8	-0.2
Pain all over the body in last month	0.6	0.6	1.3	-1.1	0.7	-0.6	0.8	-0.6	-1.0	-0.0	-1.1	-0.2	-1.0	-1.0	-0.4
Diabetes (self-reported)	1.2	1.8	3.2	1.8	-0.8	1.6	-1.4	1.4	1.4	0.8	1.4	0.8	1.5	1.2	1.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.4	0.3	0.5	0.9	-0.3	1.2	0.5	-0.1	1.1	0.8	0.2	0.7	1.2
Medication: Ramipril	0.2	0.2	0.9	0.2	-0.5	0.2	-0.3	0.3	0.3	0.3	0.0	0.4	-0.1	0.9	1.0
Medication: Simvastatin	0.0	0.1	0.1	-0.3	-0.2	0.1	-0.2	0.2	0.1	0.2	-0.4	-0.3	-0.1	0.3	0.1
Fluid intelligence score	0.5	1.1	4.1	0.8	-0.6	0.9	-0.8	1.1	0.8	1.3	0.7	-0.2	1.1	2.0	1.2
Illnesses of siblings	2.2	3.1	6.3	-0.5	2.4	-1.6	1.8	-1.4	-2.3	-2.5	-2.0	-0.7	-2.4	-0.9	-0.8
Neuroticism score	0.4	0.8	2.8	-0.6	-1.7	-1.0	1.0	-0.9	-0.7	0.6	-0.7	-0.4	-0.6	-0.0	-1.2
Weight	4.0	19.4	31.5	3.8	-3.4	5.5	-5.3	5.2	5.6	1.8	4.4	3.2	5.3	3.6	4.0
Impedance of arm (right)	0.1	0.5	1.7	0.7	0.1	0.5	0.2	0.8	-0.0	0.5	0.8	1.2	-0.0	1.0	1.3
Arm fat percentage (right)	0.3	1.1	3.7	-1.0	1.3	-0.4	0.7	-0.2	-0.7	-1.9	-0.7	-0.5	-0.9	-1.5	-1.1
Trunk fat-free mass	8.5	48.6	70.1	7.0	-5.2	8.1	-8.3	7.8	8.4	3.7	6.7	5.0	8.0	6.7	7.1
Hip circumference	3.6	15.3	25.0	3.1	-2.7	4.9	-4.7	4.8	5.0	1.1	4.3	2.8	4.6	3.1	3.8
Time employed in main current job	1.3	1.5	3.4	1.3	-0.9	1.3	-0.9	1.0	1.8	0.8	1.3	1.1	1.7	1.0	1.0
Alcohol intake versus 10 years previously	1.4	2.1	5.1	-0.6	2.2	-1.2	1.2	-0.8	-2.3	-1.4	-1.9	0.6	-2.0	-1.1	-0.8
Father’s age at death	0.9	1.2	3.4	1.8	-0.3	0.6	-0.5	0.5	1.1	1.8	0.5	0.4	1.4	1.7	0.9
Worrier / anxious feelings	0.6	1.1	4.4	-0.2	-1.6	0.9	-1.1	1.2	0.5	0.9	0.4	0.8	0.3	2.1	0.9
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.8	7.2	-0.7	2.0	-2.4	2.0	-2.0	-2.7	-1.5	-2.7	-0.4	-2.3	-1.5	-1.9
Falls in the last year	0.5	0.6	2.4	1.6	0.3	0.9	-0.5	1.1	0.3	-0.4	0.0	1.0	-0.2	0.8	0.9
Hair/balding pattern: Pattern 3	0.3	0.5	3.1	0.7	-1.8	0.3	-0.6	0.2	0.6	-0.1	1.0	-0.7	0.4	-0.2	-0.3
Number of live births	1.7	2.4	4.2	-0.9	1.4	-1.7	1.9	-1.7	-2.0	-1.1	-1.7	-1.4	-1.8	-0.9	-1.3
Forced expiratory volume in 1-second (FEV1)	3.8	12.7	19.6	2.6	-2.6	4.1	-3.9	4.3	3.3	2.5	3.3	3.7	3.1	4.4	4.1
Pulse rate	2.3	3.8	6.3	-1.5	2.5	-2.3	2.2	-2.0	-2.1	-1.6	-2.2	-1.0	-2.1	-2.0	-1.4
Happiness	4.9	6.0	10.2	2.2	-1.3	2.9	-3.2	2.9	2.5	1.9	2.5	1.0	2.7	2.7	2.5
Noisy workplace	0.2	0.2	0.5	-0.5	0.7	0.2	0.1	0.2	-0.6	-0.7	-0.6	0.5	-0.3	-0.4	-0.5
Qualifications: A levels/AS levels or equivalent	2.2	4.8	14.2	1.5	-0.0	2.3	-2.2	2.7	2.0	2.1	2.1	0.4	1.9	3.8	2.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.8	0.4	-0.9	0.1	-0.2	-0.0	0.9	-0.5	0.4	0.1	0.7	0.3	0.2
Mouth/teeth dental problems: Dentures	0.5	0.9	4.9	0.7	-1.7	-0.3	0.4	-0.9	0.5	-0.5	0.1	-0.6	0.1	-2.2	-0.8
Asthma	1.0	2.0	8.9	-0.6	3.0	-1.0	1.1	-0.4	-2.0	-2.0	-1.2	0.4	-1.5	-0.2	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.8	0.1	0.7	0.1	-0.2	0.2	-0.0	-0.1	0.2	-0.5	-0.0	0.9	0.2
Medication: Cholesterol lowering	0.2	0.3	0.7	-0.4	-0.5	-0.4	0.3	-0.6	-0.1	0.6	-0.7	-0.8	-0.4	-0.8	-0.7
Depression (self-reported)	1.4	1.7	2.7	1.2	-1.3	1.6	-1.4	1.3	1.6	1.1	1.6	0.9	1.4	0.5	1.2
Medication: Lansoprazole	0.4	0.5	1.5	0.2	0.2	0.8	-0.7	0.8	0.9	0.7	0.7	-1.2	0.7	0.2	-0.3
Prospective memory result	0.5	0.6	3.2	-0.7	-0.3	-0.7	0.5	-0.9	0.3	0.3	-0.2	-1.8	0.3	-0.6	-1.1
Lung cancer (father)	0.5	0.6	1.8	-0.6	-1.1	-0.9	1.3	-0.9	-0.5	0.2	-0.5	-1.0	-0.4	-0.0	-0.9
Illnesses of mother	0.5	0.6	1.5	-0.3	-0.1	1.0	-1.1	1.2	0.0	0.7	1.0	1.2	0.0	0.7	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	2.9	9.1	14.4	2.3	-1.8	3.5	-3.5	3.7	2.8	2.4	2.6	3.0	2.6	3.8	3.5
Pulse wave Arterial Stiffness index	3.3	3.8	10.1	3.2	-1.3	1.9	-2.0	2.1	1.9	0.3	1.9	1.1	1.8	2.5	2.1
Impedance of arm (left)	0.2	0.7	1.7	0.7	-0.7	0.6	0.1	0.9	0.2	0.9	0.9	1.3	0.2	1.3	1.2
Arm fat mass (right)	0.5	1.9	4.1	1.1	-0.6	2.0	-1.7	2.0	1.9	-0.5	1.4	0.9	1.6	0.4	1.0
Trunk predicted mass	8.7	49.7	71.7	7.0	-5.2	8.2	-8.3	7.8	8.5	3.8	6.8	5.1	8.1	6.9	7.2
Standing height	13.1	129.7	176.9	11.0	-9.4	12.8	-12.4	12.4	13.3	7.3	11.3	8.9	13.0	11.4	11.8
Length of working week for main job	0.2	0.3	1.1	0.2	1.0	0.0	-0.3	0.4	0.2	1.0	-0.1	0.8	-0.2	0.2	0.4
Exposure to tobacco smoke at home	1.9	2.2	4.4	-1.9	0.9	-1.4	1.2	-1.4	-1.6	-1.0	-1.4	-1.0	-2.1	-1.9	-1.4
Breastfed as a baby	0.3	0.4	1.4	-0.4	0.1	0.3	-0.4	0.3	0.6	0.2	0.6	-1.2	0.6	1.0	0.3
Tense / ‘highly strung’	2.0	3.3	13.5	1.1	-3.7	1.3	-1.4	1.1	2.3	1.5	1.6	0.9	2.4	1.7	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.6	0.9	0.5	1.1	-0.8	1.5	0.2	-0.5	0.7	1.5	0.2	1.5	1.6
Hair/balding pattern: Pattern 4	0.8	2.1	5.8	1.5	0.8	1.3	-1.1	1.8	-0.0	1.1	0.5	1.9	0.1	2.4	2.2
Birth weight of first child	0.1	0.1	0.4	0.2	0.3	0.1	0.1	0.1	-0.1	-0.6	0.4	-0.6	-0.2	0.5	0.4
Peak expiratory flow (PEF)	3.9	8.9	13.5	2.7	-2.1	3.5	-3.1	3.5	2.9	1.1	3.1	3.1	2.7	3.6	3.7
Pulse wave reflection index	2.2	2.7	8.8	3.0	-1.0	1.5	-1.5	1.4	1.4	1.0	1.5	1.2	1.4	2.2	1.8
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.6	-0.6	0.9	-1.2	1.2	-1.0	-1.6	-0.8	-0.9	0.1	-1.4	-1.0	-0.9
Loud music exposure frequency	5.5	6.0	14.6	-2.1	3.8	-2.3	2.3	-1.8	-3.5	-2.6	-2.5	-0.6	-3.1	-1.6	-1.5
Qualifications: O levels/GCSEs or equivalent	2.5	4.0	7.9	1.7	0.0	2.4	-2.3	2.5	2.0	0.3	2.4	0.8	1.8	2.6	2.8
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	2.5	-0.4	-0.4	0.5	-1.2	0.6	0.6	1.3	0.4	1.6	0.7	0.8	0.8
Blood clot in the leg (DVT)	0.7	0.9	3.2	0.1	1.8	-0.8	0.7	-0.6	-1.2	-0.0	-1.6	0.6	-1.0	-0.1	-0.8
Medication: Paracetamol	0.6	1.0	1.9	-0.9	1.1	-1.1	0.9	-1.0	-0.9	1.4	-0.9	-1.1	-0.8	-0.5	-1.1
Headache pain in last month	0.6	1.0	3.1	-1.1	0.2	-1.2	0.8	-1.0	-1.1	-0.3	-1.1	0.2	-0.9	-0.7	-1.8
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.9	0.2	0.9	-0.0	0.2	0.3	-0.3	-0.2	0.1	0.9	-0.2	0.7	0.3
Glaucoma (self-reported)	0.3	0.4	1.5	0.8	-0.4	0.6	-0.4	0.7	0.4	1.2	-0.2	0.1	0.3	0.7	0.5
Gout (self-reported)	1.3	1.8	3.2	0.0	-1.4	1.7	-1.6	1.4	1.8	1.5	1.5	0.1	1.8	1.3	0.6
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	4.2	0.8	2.1	0.6	-0.5	1.3	-0.7	-0.6	-0.7	1.3	-0.5	1.4	0.8
Medication: Amlodipine	0.9	1.3	4.0	2.0	-1.2	0.8	-1.2	0.4	1.6	0.4	1.1	-1.1	1.2	0.5	1.1
Medication: Ventolin 100micrograms inhaler	0.7	0.9	5.1	-0.0	2.3	-0.5	0.8	-0.0	-1.4	-0.8	-0.8	-0.1	-1.2	0.1	-0.2
Birth weight	0.3	0.6	1.4	-0.5	0.3	-1.2	1.1	-1.0	-0.8	-0.2	-1.0	-0.0	-0.8	-0.3	-0.9
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.6	-0.9	0.6	-1.4	1.4	-1.5	-0.8	-1.3	-0.7	-1.3	-0.9	-1.6	-1.2
High blood pressure (siblings)	1.6	2.4	10.1	-0.1	-2.1	1.3	-1.6	1.0	1.6	3.2	1.2	0.3	2.1	0.6	-0.0
Forced vital capacity (FVC), Best measure	4.4	16.0	24.9	3.4	-1.9	4.8	-4.6	5.0	3.7	2.7	3.6	3.9	3.5	4.8	4.7
Body fat percentage	0.1	0.6	3.2	-0.5	-0.1	0.0	0.5	-0.1	0.2	-1.3	-0.1	-0.2	-0.0	-1.8	-1.1
Leg fat percentage (right)	1.3	4.9	16.5	-1.9	0.7	-1.9	2.3	-2.3	-1.3	-2.5	-1.6	-1.7	-1.3	-4.1	-3.0
Arm fat-free mass (right)	6.6	34.1	52.3	5.5	-4.8	6.9	-6.9	6.5	7.2	3.2	5.5	4.2	6.8	5.2	5.6
Exposure to tobacco smoke outside home	0.3	0.4	1.3	-0.4	1.1	-0.4	0.3	-0.3	-1.0	-0.0	-0.3	-0.4	-1.2	-0.4	0.1
Comparative body size at age 10	1.4	4.0	5.9	-1.7	1.9	-2.1	2.0	-2.1	-2.0	-2.0	-1.8	-1.6	-2.0	-2.4	-2.1
Number of full brothers	0.7	0.8	1.5	0.0	-0.8	-1.2	1.2	-1.2	-0.7	-0.7	-0.5	-0.7	-0.9	-1.1	-1.0
Worry too long after embarrassment	0.8	1.3	2.7	-1.6	-0.6	-1.4	1.1	-1.3	-1.0	0.3	-0.8	-1.7	-1.5	-0.4	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	2.6	-1.1	0.1	-1.2	1.1	-1.3	-0.8	-0.4	-0.9	-0.8	-0.9	-1.5	-1.6
Wheeze or whistling in the chest in last year	1.1	1.9	5.2	-1.3	1.4	-1.1	1.4	-1.1	-1.4	-1.6	-1.0	-0.0	-1.5	-2.3	-1.3
Number of children fathered	0.2	0.2	2.0	-0.0	0.2	0.0	0.0	-0.4	0.6	-0.1	0.1	0.2	0.4	-1.4	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.3	-1.5	-0.2	-0.9	1.1	-1.0	-0.6	0.1	-1.3	-0.0	-0.5	-1.0	-1.4
Age at first live birth	3.4	6.1	9.5	1.7	-2.7	2.7	-2.9	2.6	2.9	1.5	2.7	0.2	2.9	3.1	2.3
Pulse wave peak to peak time	1.3	1.5	6.0	-2.5	0.5	-1.1	1.1	-1.2	-1.0	0.0	-1.1	-0.6	-1.0	-1.7	-1.3
Health satisfaction	2.2	2.9	5.0	1.5	-0.6	2.1	-2.0	1.9	2.2	1.6	1.6	1.3	2.0	1.1	1.6
Shortness of breath walking on level ground	0.7	0.9	1.6	-0.8	0.4	-1.2	1.3	-1.0	-1.0	-1.2	-0.6	0.3	-1.2	-0.8	-0.8
Qualifications: College or University degree	2.0	6.3	16.4	2.0	-2.1	1.9	-2.2	2.1	3.0	2.1	2.5	0.9	2.7	4.1	3.1
Eye problems/disorders: None of the above	0.2	0.2	1.0	0.2	0.8	-0.3	0.5	-0.3	-0.2	-0.5	0.1	-1.0	-0.4	0.2	-0.1
Mouth/teeth dental problems: Loose teeth	1.0	1.2	5.1	-1.6	2.3	-0.3	0.3	0.1	-1.3	-0.3	-1.0	-0.6	-1.5	-0.2	-0.8
Emphysema/chronic bronchitis	0.2	0.2	0.6	-0.7	0.6	-0.1	-0.0	-0.0	-0.2	-0.8	-0.0	0.2	-0.2	-0.6	-0.3
Medication for pain relief, constipation, heartburn	0.6	1.0	2.2	0.8	-0.7	1.0	-0.9	1.0	1.4	0.4	1.2	0.6	1.5	0.7	1.1
Neck or shoulder pain in last month	2.3	3.3	6.3	-1.5	1.9	-1.8	1.8	-1.5	-2.3	-2.1	-2.0	-1.0	-2.5	-1.5	-1.3
Medication: Blood pressure	0.7	1.2	3.8	1.1	-1.9	1.0	-1.2	0.7	1.5	0.7	0.7	-0.2	1.4	0.5	0.7
Angina (self-reported)	0.2	0.2	0.7	0.7	-0.9	-0.1	-0.0	-0.3	0.7	0.7	0.5	-0.3	0.3	0.1	0.4
Migraine (self-reported)	0.2	0.2	0.7	-0.4	0.8	0.2	-0.7	0.2	0.1	-0.8	0.5	-0.5	0.1	0.5	0.4
Medication: Ibuprofen	0.2	0.3	0.6	0.8	0.6	0.4	-0.5	0.5	0.2	-0.1	0.2	0.6	0.2	0.8	0.7
Medication: Allopurinol	1.8	2.4	4.7	0.2	-1.9	1.6	-1.8	1.3	2.2	2.0	1.8	-0.1	2.1	0.9	0.3
Medication: Omeprazole	0.6	0.8	2.0	0.3	-0.9	-1.2	1.2	-1.4	-0.2	-0.0	-0.8	0.5	-0.3	-1.4	-0.6
Medication: Seretide 50 evohaler	0.3	0.3	0.9	0.9	0.6	0.6	-0.5	0.6	0.1	-0.7	0.3	0.4	0.4	0.5	0.2
Mean time to correctly identify matches	1.4	2.6	4.5	1.1	-0.5	1.9	-1.9	1.9	1.7	1.3	1.8	1.2	1.7	2.1	1.5
Heart disease (mother)	0.8	1.0	3.2	1.0	-1.8	0.7	-0.8	0.4	1.5	0.5	1.0	-0.0	1.5	0.4	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.7	0.7	-1.8	0.7	-1.0	0.5	1.4	1.9	1.0	0.5	1.3	1.3	0.3
Whole body fat mass	1.0	4.1	8.4	1.8	-1.8	2.7	-2.3	2.5	2.9	0.2	2.1	1.5	2.6	0.6	1.4
Leg fat mass (right)	0.2	0.8	2.1	0.5	-1.1	1.0	-0.6	0.6	1.4	-0.8	0.8	0.1	1.3	-1.2	-0.4
Arm predicted mass (right)	6.7	34.5	55.2	5.5	-5.1	7.0	-7.0	6.5	7.4	3.3	5.7	3.9	7.0	5.1	5.5
Pulse rate, automated reading	2.0	6.4	10.0	-1.5	3.1	-2.8	2.5	-2.4	-2.9	-2.5	-3.2	-1.3	-2.8	-2.5	-1.8
Alcohol intake frequency.	5.1	11.9	20.4	-0.9	4.1	-3.7	3.7	-3.3	-4.5	-3.2	-4.5	-1.4	-4.3	-2.7	-2.8
Comparative height size at age 10	14.1	77.7	110.2	8.4	-8.0	9.9	-9.5	9.4	10.5	5.7	9.0	7.3	10.2	8.1	8.7
Number of full sisters	0.5	0.6	2.7	0.3	0.9	-0.2	0.2	-0.2	-0.3	-1.6	-0.9	-0.1	-0.1	-1.2	-1.2
Suffer from ‘nerves’	0.6	1.0	2.4	-1.6	-1.4	-1.0	1.1	-0.9	-1.0	-0.7	-0.7	-0.5	-1.2	-0.6	-1.0
Overall health rating	0.4	0.9	1.8	-0.1	1.0	-0.7	0.9	-0.6	-1.1	-1.1	-1.3	0.1	-1.2	-0.7	-1.2
Chest pain or discomfort	0.4	0.6	2.8	-0.1	1.7	-0.1	0.3	0.1	-0.9	-1.1	-0.2	0.6	-1.1	-0.2	0.5
Had major operations	1.2	1.4	4.0	-0.2	1.3	-1.2	1.1	-1.2	-1.0	0.6	-1.8	-0.5	-1.1	-2.0	-1.2
Age at last live birth	1.4	2.0	4.8	1.4	-1.5	1.4	-1.5	1.2	1.5	0.5	1.6	0.2	1.7	2.2	1.5
Family relationship satisfaction	0.1	0.1	0.2	0.2	-0.5	-0.1	-0.3	-0.1	0.4	0.5	0.1	-0.4	0.3	0.1	0.1
Leg pain on walking	0.5	0.7	1.8	0.5	-0.4	1.1	-1.1	0.9	0.7	0.5	0.7	0.6	0.6	0.7	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	4.6	-1.3	1.1	-0.4	0.6	-0.4	-0.7	-2.1	-0.4	-0.1	-0.7	-1.2	-0.7
Commuting to job workplace: Car/motor vehicle	2.5	2.9	6.0	1.7	-0.5	2.0	-2.4	2.0	1.2	0.5	2.0	2.1	1.1	1.6	2.1
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	3.3	-0.4	-0.4	1.4	-1.6	1.5	0.9	1.8	1.2	0.3	1.0	1.3	1.2
Medication: Aspirin	0.5	0.7	2.2	-0.9	0.4	-0.7	0.4	-0.6	-1.1	-1.5	-1.0	0.3	-1.0	-0.6	-0.4
Supplements: Vitamin C	0.6	0.7	2.5	-0.5	0.7	0.8	-1.0	1.0	0.5	0.5	0.8	-0.7	0.4	1.6	0.7
Knee pain experienced in last month	3.7	5.7	10.0	-1.9	1.6	-2.5	2.3	-2.5	-2.2	-2.9	-2.5	-1.4	-2.2	-3.2	-2.9
Hypertension (Self-reported)	1.5	4.2	7.2	2.5	-2.2	2.2	-2.6	2.0	2.7	0.6	1.6	0.0	2.6	2.0	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.9	1.0	0.3	0.2	0.2	-0.1	0.1	0.4	0.3	0.3	0.4	-0.8	-0.0
Illnesses of father: Heart disease	1.8	2.5	4.3	1.5	-2.1	1.7	-2.1	1.7	1.4	1.2	1.6	0.8	1.5	1.7	1.3
Illnesses of siblings: Diabetes	0.3	0.3	1.2	-1.1	0.6	-0.3	0.6	-0.2	-0.1	0.3	-0.5	0.5	-0.3	-0.8	-0.8
Smoking status: Previous	7.1	10.6	15.8	-3.9	2.5	-3.4	3.5	-3.1	-4.0	-0.8	-3.1	-2.9	-3.5	-3.0	-3.9
Forced expiratory volume in 1-second (FEV1), predicted	6.0	12.4	16.6	2.8	-3.3	4.1	-4.0	4.0	3.9	2.1	3.0	3.3	3.7	3.9	3.6
Whole body fat-free mass	8.2	47.1	67.6	6.6	-5.0	8.2	-8.2	7.8	8.2	3.7	6.6	4.9	7.8	6.7	6.9
Leg fat-free mass (right)	7.2	38.6	57.6	5.5	-4.4	7.6	-7.6	7.4	7.4	3.2	6.0	4.3	6.9	6.3	6.1
Arm fat percentage (left)	0.2	0.9	3.3	-1.0	0.8	-0.3	0.7	-0.2	-0.5	-1.8	-0.5	-0.4	-0.7	-1.5	-1.2
Average weekly red wine intake	0.2	0.2	0.7	-0.1	-0.0	-0.8	0.6	-0.7	-0.4	-0.4	-0.4	-0.1	-0.7	-0.3	0.2
Handedness (chirality/laterality): Left-handed	1.2	1.4	7.4	2.7	-0.1	1.0	-0.8	0.9	0.8	0.8	0.4	1.5	1.3	0.9	0.8
Mood swings	0.4	0.6	2.0	-0.5	-0.7	-0.9	0.9	-1.0	-0.5	-0.3	-1.0	-0.6	-0.2	-0.6	-1.4
Loneliness, isolation	3.4	4.7	7.8	-1.5	1.4	-2.5	2.3	-2.7	-2.1	-0.4	-2.8	-2.1	-1.9	-2.4	-2.7
Long-standing illness, disability or infirmity	2.2	3.3	10.0	-0.6	3.1	-1.4	1.3	-0.8	-2.4	-1.9	-3.2	0.8	-2.2	-0.3	-0.8
Ever had bowel cancer screening	0.2	0.3	1.6	0.6	0.2	0.4	-0.4	0.4	-0.2	-0.6	-0.2	1.2	-0.0	0.1	0.7
Diabetes diagnosed by doctor	0.8	1.3	2.6	1.6	-0.8	1.3	-1.2	1.3	0.9	0.2	0.9	0.8	1.1	1.3	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	2.3	-1.5	-0.2	-0.2	0.3	-0.1	-0.5	-0.4	0.1	0.2	-0.7	-0.4	-1.0
Friendships satisfaction	2.7	3.3	5.8	0.7	-0.8	2.3	-2.4	2.3	2.0	1.0	2.0	0.6	1.6	2.1	2.3
Qualifications: nursing, teaching	0.2	0.3	1.9	-0.5	-0.3	-0.3	0.2	-0.1	0.2	0.8	0.3	-1.4	0.1	0.5	0.1
Commuting to job workplace: Walk	4.0	4.3	8.7	-1.9	1.5	-2.1	2.3	-2.1	-2.1	-0.5	-3.0	-1.6	-2.2	-2.1	-2.5
Eye problems/disorders: Cataract	0.3	0.3	1.9	0.7	-1.4	0.0	-0.1	0.0	0.4	-0.2	0.1	0.8	0.4	0.0	0.1
Mouth/teeth dental problems: Mouth ulcers	2.4	3.8	6.5	-1.6	2.5	-2.2	1.9	-1.8	-2.4	-1.3	-2.6	-0.8	-2.2	-1.0	-2.1
Medication for cholesterol	0.8	1.2	2.8	-1.1	0.8	-1.2	0.9	-1.0	-1.7	0.1	-0.8	-0.6	-1.7	-1.1	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	2.2	0.0	0.8	0.3	-0.0	0.5	-0.5	0.4	-0.4	1.5	-0.7	0.1	-0.1
Back pain experienced in last month	1.3	1.9	5.2	0.7	1.2	-1.2	1.2	-1.0	-1.7	-0.8	-2.3	1.0	-1.7	-1.5	-1.4
Mineral and other dietary supplements	0.2	0.2	1.6	-0.4	-1.3	-0.1	-0.1	-0.2	0.3	-0.7	0.5	-0.3	0.3	-0.2	-0.3
Breast cancer (self-reported)	0.9	1.1	2.0	0.2	-0.7	1.3	-1.1	1.2	1.1	1.2	0.8	1.1	1.4	1.3	0.6
Asthma (self-reported)	1.0	2.0	9.9	-0.5	3.1	-0.9	1.1	-0.2	-2.0	-1.8	-1.1	0.4	-1.6	-0.1	-0.5
Osteoporosis (self-reported)	0.5	0.6	1.7	0.1	0.8	-0.7	0.6	-0.7	-0.8	-0.4	-1.3	-1.0	-0.6	-0.8	-0.8
Osteoarthritis (self-reported)	2.7	3.5	6.6	-0.7	2.6	-1.9	1.7	-1.8	-1.8	-1.8	-2.3	-0.2	-2.2	-2.4	-1.5
Medication: Aspirin	0.2	0.3	1.3	-0.3	-0.0	-0.5	0.2	-0.5	-0.7	-1.1	-0.7	0.4	-0.6	-0.4	0.1
Medication: Gliclazide	0.8	0.9	1.8	-1.3	1.3	-0.7	0.5	-0.6	-1.0	-1.4	-0.5	-1.2	-1.2	-0.6	-0.4
Illnesses of father: None of the above (group 1)	3.9	4.8	8.6	-2.5	1.0	-2.6	2.8	-2.8	-1.6	-0.5	-1.4	-2.9	-1.6	-2.5	-2.5
Smoking status: Current	0.7	1.1	4.7	1.1	1.3	-0.0	0.4	0.1	-1.0	-1.6	-0.7	2.2	-1.1	-0.8	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	3.2	-0.5	0.4	1.4	-1.6	1.6	0.1	1.8	0.5	1.3	-0.3	1.7	1.7
Whole body water mass	7.8	44.7	64.6	6.4	-4.8	8.0	-8.0	7.7	8.0	3.5	6.4	4.8	7.5	6.5	6.8
Leg predicted mass (right)	7.0	37.5	55.7	5.5	-4.4	7.5	-7.5	7.3	7.3	3.1	5.9	4.2	6.8	6.2	6.0
Arm fat mass (left)	0.5	1.9	4.0	1.1	-0.8	2.0	-1.7	2.0	1.9	-0.4	1.4	1.1	1.6	0.5	1.0
Number of self-reported non-cancer illnesses	0.3	0.5	1.8	0.7	1.4	0.6	-0.8	0.8	0.3	-1.0	-0.1	0.6	-0.0	0.5	0.9
Average weekly champagne plus white wine intake	6.4	8.9	13.7	2.4	-2.9	3.1	-2.9	2.9	3.5	3.2	3.5	0.7	3.7	3.6	2.3
Miserableness	0.7	1.3	2.6	-0.6	0.8	-1.1	1.4	-1.0	-1.6	-1.1	-1.4	0.4	-1.3	-0.9	-1.2
Guilty feelings	0.4	0.6	1.9	-0.7	-0.1	-0.8	0.9	-0.4	-1.2	-1.3	-0.8	-0.3	-1.4	0.3	-0.1
Wears glasses or contact lenses	0.4	0.5	2.0	-0.6	-0.8	0.4	-0.5	0.4	0.7	0.4	1.4	-1.1	0.3	0.7	0.4
Ever taken oral contraceptive pill	0.8	0.9	3.8	-2.0	1.3	-0.8	1.0	-0.6	-1.4	-0.3	-0.2	-0.3	-1.1	0.0	-0.4
Hearing aid user	4.0	4.5	6.6	-1.8	2.5	-2.1	2.3	-2.1	-2.2	-2.1	-2.6	-1.2	-1.8	-2.1	-2.5
Mother’s age at death	0.3	0.4	2.0	0.9	1.4	-0.2	0.1	-0.0	-0.4	-0.7	-0.1	0.3	-0.3	0.3	0.6
Financial situation satisfaction	0.7	0.9	3.7	0.8	1.6	0.9	-0.8	1.1	-0.4	-0.5	-0.1	1.9	-0.3	0.5	1.0
Tinnitus: Yes, now most or all of the time	3.6	4.2	5.7	-1.5	2.4	-2.2	2.3	-2.3	-2.1	-0.5	-2.3	-1.7	-2.0	-2.2	-2.2
Commuting to job workplace: Public transport	0.5	0.5	1.9	0.8	0.3	0.9	-0.6	1.1	0.2	-0.4	0.1	0.3	0.3	1.4	1.1
Eye problems/disorders: Glaucoma	0.3	0.4	1.7	0.2	-0.7	0.6	-0.5	0.7	0.4	1.3	-0.4	0.4	0.5	0.5	0.1
Medication: Blood pressure	2.6	4.9	9.2	2.3	-1.9	2.7	-2.5	2.4	3.0	0.5	2.0	0.4	2.9	2.2	1.9
Pain type(s) experienced in last month: Hip pain	0.9	1.2	2.4	-0.4	1.5	-1.0	0.8	-0.8	-1.1	-1.6	-0.9	1.1	-1.1	-1.4	-0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.5	-0.0	0.7	-0.4	0.5	-0.4	-0.2	0.3	-0.4	0.2	-0.4	-0.6	-0.5
High cholesterol (Self-reported)	0.1	0.2	0.7	-0.5	-0.8	0.3	-0.3	0.1	0.6	-0.4	0.1	-0.4	0.2	-0.2	-0.2
Medication: Bendroflumethiazide	1.4	2.1	5.0	1.7	-1.9	1.3	-1.5	0.7	2.2	0.9	1.4	-0.6	2.2	0.4	0.9
Medication: Paracetamol	0.2	0.2	1.9	0.3	0.5	-0.4	0.3	-0.4	-0.3	1.4	-0.3	0.1	-0.2	-0.1	-0.2
Medication: Lisinopril	0.8	1.1	3.6	0.5	-1.1	0.9	-1.0	0.8	1.1	1.9	0.4	0.4	1.5	1.1	0.3
Medication: Atorvastatin	0.4	0.6	2.2	1.5	-0.7	0.8	-0.5	0.5	0.7	-0.0	0.6	1.1	0.6	0.2	0.5
Illnesses of father: High blood pressure	1.1	1.3	4.4	1.4	0.3	1.1	-1.0	1.4	0.6	-0.1	0.2	2.1	0.9	1.8	1.1
Alcohol drinker status: Never	0.1	0.2	0.6	0.8	-0.6	0.1	0.1	-0.1	0.2	0.5	0.7	-0.5	0.3	0.2	-0.0
Ever smoked	5.7	9.9	16.3	-3.6	3.0	-3.1	3.4	-2.8	-4.0	-1.6	-3.0	-1.7	-3.9	-3.6	-3.1
Basal metabolic rate	6.9	38.3	56.7	5.8	-4.6	7.5	-7.4	7.2	7.5	3.1	6.0	4.3	7.1	5.8	6.1
Leg fat percentage (left)	1.1	3.9	13.8	-1.8	0.5	-1.6	2.0	-2.0	-1.0	-2.3	-1.4	-1.4	-1.1	-3.7	-2.8
Arm fat-free mass (left)	5.9	29.9	46.4	5.2	-4.1	6.6	-6.6	6.3	6.8	2.6	5.2	3.8	6.3	5.0	5.4
Number of operations (self-reported)	1.0	1.4	2.8	-1.5	1.6	-1.1	0.8	-0.8	-1.5	-1.4	-1.4	0.3	-1.7	-0.9	-0.5
Average weekly beer plus cider intake	0.3	0.5	1.4	-0.3	-0.9	0.5	-0.6	0.5	0.8	1.2	-0.0	1.0	1.0	0.3	-0.2
Irritability	0.3	0.5	1.2	-0.1	-1.0	0.7	-0.5	0.9	0.5	-0.1	1.0	1.1	0.7	0.9	0.5
Risk taking	0.2	0.3	1.7	-0.3	1.3	0.1	0.3	0.1	0.1	-0.3	-0.2	0.9	-0.2	-0.3	0.0
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.6	-1.0	0.6	-1.3	1.3	-1.0	-1.6	-1.9	-1.5	-0.3	-1.5	-0.6	-1.0
Fractured/broken bones in last 5 years	0.3	0.4	2.4	1.5	0.0	-0.4	0.5	-0.4	-0.2	-0.4	-1.0	0.9	-0.2	-0.5	-0.0
Age started oral contraceptive pill	1.3	1.6	4.1	0.8	-0.6	1.3	-1.3	1.0	1.5	1.1	1.3	2.0	1.3	0.6	1.6
Diastolic blood pressure, automated reading	0.5	1.6	4.7	0.9	-1.9	1.2	-1.5	0.8	2.2	0.2	1.3	-0.2	1.9	-0.3	0.4
Ever depressed for a whole week	1.6	2.0	5.4	0.9	-0.7	1.7	-1.6	1.7	1.3	0.1	1.9	1.0	1.3	1.3	2.3
Unable to work because of sickness or disability	2.3	2.9	5.8	-0.8	2.3	-1.3	1.5	-1.2	-2.2	-2.4	-1.9	-0.2	-2.1	-1.5	-1.6
Commuting to job workplace: Cycle	1.0	1.2	3.4	0.7	-0.6	1.1	-1.2	1.2	1.1	0.4	1.1	0.5	1.0	1.8	1.7
Myopia	0.2	0.3	1.9	0.8	-0.3	0.1	-0.0	0.2	0.4	1.4	0.2	-0.4	0.0	0.3	0.0
Vascular/heart problems diagnosed by doctor	1.3	3.5	6.6	-2.6	1.9	-1.9	2.3	-1.7	-2.5	-0.6	-1.4	-0.0	-2.3	-1.9	-1.6
Cholesterol lowering medication	0.2	0.3	1.5	0.9	-0.1	-0.3	0.6	-0.3	-0.1	-1.2	-0.5	0.5	-0.1	-0.1	0.5
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	4.9	-0.3	-0.4	-1.7	1.9	-2.0	-0.5	-0.3	-1.2	0.0	-0.7	-2.2	-1.2
Pain experienced in last month	2.3	3.9	5.9	1.3	-0.7	2.3	-2.1	2.0	2.2	2.4	2.3	0.1	2.2	2.0	2.3
Supplements: Calcium	0.3	0.3	1.4	-0.2	1.2	-0.3	0.4	-0.2	-0.7	0.9	-0.5	-0.3	-0.6	0.2	-0.2
Basal cell carcinoma (self-reported)	0.2	0.2	1.6	0.5	-0.4	-0.4	0.2	-0.3	-0.0	-1.3	0.0	0.2	-0.2	-0.5	0.1
Heart attack/myocardial infarction (self-reported)	2.0	2.5	4.8	-1.0	1.1	-2.2	1.8	-2.2	-1.4	-0.1	-1.9	-1.2	-1.7	-1.6	-1.6
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	5.8	0.1	2.4	-0.7	0.7	-0.5	-1.5	-0.0	-1.8	0.6	-1.2	-0.1	-0.8
Heart disease (siblings)	0.2	0.2	1.0	0.5	0.3	0.5	-0.6	0.2	0.4	1.0	0.1	0.4	0.1	-0.4	0.3
Alcohol drinker status: Previous	1.1	1.2	3.1	-0.0	1.8	-1.0	1.0	-0.6	-1.3	-1.7	-1.6	0.3	-1.4	-0.3	-0.3
Pack years of smoking	0.3	0.5	2.0	1.4	-0.5	0.4	-0.2	0.3	0.7	-0.9	0.5	0.6	0.8	-0.2	0.6
Impedance of whole body	0.1	0.4	2.2	-0.1	-0.8	-0.7	1.5	-0.6	-0.6	0.3	0.1	0.4	-0.4	-0.5	-0.2
Leg fat mass (left)	0.2	1.0	2.6	0.5	-1.2	1.1	-0.8	0.8	1.6	-0.7	0.9	0.3	1.4	-1.0	-0.3
Arm predicted mass (left)	6.5	33.0	49.7	5.7	-4.2	6.9	-6.9	6.5	7.0	2.6	5.5	4.2	6.6	5.2	5.8