TWAS hub - METRN

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0533	0.0132	3.9e-10	0.059	0.028	0.055	0.052	0.058	9.1e-19	1.1e-09	2.0e-17	1.2e-16	2.0e-18
2	TCGA	Breast Invasive Carcinoma	0.0201	0.0123	1.9e-03	0.016	0.013	0.007	NA	0.016	1.9e-04	1.0e-03	1.3e-02	NA	2.0e-04
3	TCGA	Colon Adenocarcinoma	0.0520	0.0330	9.5e-03	0.029	0.040	0.028	NA	0.023	8.0e-03	2.3e-03	8.8e-03	NA	1.7e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Comparative height size at age 10	19.2	105.6	112.4	10.3	9.9	10.6
Standing height	18.0	178.1	198.8	13.2	12.7	14.1
Height	17.5	336.5	368.6	18.2	17.6	19.2
Sitting height	14.1	99.8	110.2	9.9	9.5	10.5
Trunk predicted mass	12.8	73.2	78.9	8.6	8.2	8.9
Trunk fat-free mass	12.5	71.9	77.1	8.5	8.1	8.8
Whole body fat-free mass	12.5	71.3	74.1	8.5	8.2	8.6
Whole body water mass	12.0	68.2	70.6	8.3	8.0	8.4
Leg fat-free mass (right)	11.4	60.7	62.3	7.8	7.7	7.9
Leg predicted mass (right)	11.0	58.9	60.7	7.7	7.5	7.8
Basal metabolic rate	10.7	59.0	61.2	7.8	7.5	7.7
Leg fat-free mass (left)	10.4	55.1	55.8	7.5	7.3	7.5
Leg predicted mass (left)	10.4	55.2	56.1	7.5	7.3	7.5
Arm predicted mass (right)	10.1	51.6	53.0	7.3	7.0	7.2
Arm fat-free mass (right)	10.0	51.3	53.3	7.3	7.0	7.2
Arm predicted mass (left)	10.0	50.9	53.4	7.3	7.0	7.1
Smoking status: Previous	9.2	13.8	18.6	-3.4	-3.3	-4.3
Arm fat-free mass (left)	9.2	46.5	48.6	7.0	6.7	6.8
Forced expiratory volume in 1-second (FEV1), predicted	8.3	17.2	18.1	4.2	4.0	4.2
Average weekly champagne plus white wine intake	7.4	10.2	13.5	2.9	3.0	3.7
Past tobacco smoking	7.3	13.5	20.5	3.2	3.1	4.5
Ever smoked	7.3	12.8	20.9	-3.0	-2.9	-4.6
Forced vital capacity (FVC)	7.0	26.9	28.7	5.4	5.1	5.0
Happiness	6.8	8.2	8.4	2.9	2.9	2.8
Qualifications: None of the above	6.5	13.9	22.0	-3.1	-3.1	-4.7
Forced vital capacity (FVC), Best measure	6.4	23.4	25.1	5.0	4.8	4.7
Weight	6.3	31.1	34.1	5.8	5.7	5.2
Alcohol intake frequency.	6.2	14.4	16.3	-3.6	-3.7	-4.0
Number of incorrect matches in round	6.0	9.9	12.9	3.0	2.9	3.6
Hip circumference	5.8	24.9	27.4	5.2	5.1	4.6
Age at First Birth	5.7	8.3	11.4	2.6	2.6	3.4
Peak expiratory flow (PEF)	5.3	12.2	12.8	3.5	3.3	3.6
Loud music exposure frequency	5.3	5.8	8.8	-2.0	-2.1	-3.0
Hearing difficulty/problems with background noise	5.0	8.0	9.5	-3.0	-3.1	-2.3
Forced expiratory volume in 1-second (FEV1)	5.0	16.8	17.6	4.2	4.0	4.1
Age at first live birth	4.9	8.7	12.8	2.6	2.6	3.6
Illnesses of father: None of the above (group 1)	4.8	6.0	7.0	-2.7	-2.6	-2.0
Loneliness, isolation	4.5	6.2	6.5	-2.4	-2.5	-2.5
Commuting to job workplace: Walk	4.5	4.8	5.3	-2.3	-2.2	-2.1
Medication: Blood pressure	4.5	8.5	11.5	2.7	2.6	3.4
Tinnitus: Yes, now most or all of the time	4.4	5.1	5.7	-2.2	-2.2	-2.4
Smoking Status	4.3	10.2	20.1	-2.3	-2.3	-4.5
Knee pain experienced in last month	4.3	6.6	9.1	-2.3	-2.3	-3.0
Hearing aid user	4.3	4.8	6.5	-2.0	-2.0	-2.5
Friendships satisfaction	4.2	5.2	5.8	2.2	2.2	2.4
Forced expiratory volume in 1-second (FEV1), Best measure	4.0	12.7	13.3	3.6	3.5	3.6
Qualifications: O levels/GCSEs or equivalent	3.9	6.3	7.1	2.4	2.4	2.7
Pulse wave Arterial Stiffness index	3.7	4.4	5.3	2.0	1.9	2.3
Fed-up feelings	3.6	6.6	7.1	-2.5	-2.5	-2.7
Blood Platelet Count	3.5	40.3	52.7	-5.9	-5.8	-7.3
Severe depression (siblings)	3.5	3.9	4.5	-2.0	-2.1	-1.8
Townsend deprivation index at recruitment	3.5	4.9	7.1	-1.9	-2.0	-2.7
Health satisfaction	3.4	4.4	4.6	2.2	2.1	2.0
Frequency of tiredness / lethargy in last 2 weeks	3.2	5.2	6.0	-2.0	-2.3	-2.5
Pulse rate	3.2	5.4	6.4	-2.2	-2.2	-2.5
Qualifications: A levels/AS levels or equivalent	3.2	7.2	11.0	2.3	2.3	3.3
Pain experienced in last month	3.1	5.2	6.3	2.1	2.2	2.5
Blood Eosinophil Count	3.0	23.0	23.8	4.9	4.8	4.7
Heart attack/myocardial infarction (self-reported)	3.0	3.8	4.7	-2.2	-2.2	-1.4
Commuting to job workplace: Car/motor vehicle	2.9	3.3	4.0	2.0	2.0	1.4
Mouth/teeth dental problems: Mouth ulcers	2.8	4.5	4.8	-2.2	-2.2	-2.0
Osteoarthritis (self-reported)	2.8	3.6	4.5	-1.8	-1.8	-2.1
High blood pressure	2.7	7.6	10.8	2.5	2.4	3.3
Qualifications: College or University degree	2.7	8.5	18.4	2.0	1.8	4.3
Trunk fat mass	2.6	11.2	13.1	3.6	3.6	2.7
Hearing difficulty/problems: Yes	2.5	3.7	4.7	-2.0	-2.2	-1.5
Neck or shoulder pain in last month	2.4	3.5	4.2	-1.8	-1.8	-2.0
Pulse rate, automated reading	2.4	7.8	9.9	-2.5	-2.7	-3.2
Reaction Time	2.3	4.3	6.2	1.8	1.9	2.5
Heart attack	2.3	3.0	3.8	-1.9	-1.9	-1.2
Pulse wave reflection index	2.3	2.8	4.0	1.6	1.4	2.0
Hypertension (Self-reported)	2.3	6.4	9.2	2.3	2.1	3.0
HbA1C	2.2	2.4	3.1	-1.4	-1.5	-1.8
Number of live births	2.2	3.2	3.5	-1.9	-1.9	-1.6
Exposure to tobacco smoke at home	2.1	2.3	3.1	-1.4	-1.3	-1.8
Unable to work because of sickness or disability	2.1	2.7	4.8	-1.3	-1.3	-2.2
Schizophrenia (2014)	2.0	4.4	5.1	2.2	1.9	2.3
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	2.8	1.7	1.5	1.2
Illnesses of siblings	2.0	2.8	3.0	-1.7	-1.7	-1.6
Ever depressed for a whole week	2.0	2.5	2.7	1.6	1.6	1.4
Waist circumference	1.9	7.0	8.9	3.0	2.9	1.9
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	2.8	1.7	1.6	1.2
Comparative body size at age 10	1.9	5.3	8.2	-2.0	-2.0	-2.9
Mean time to correctly identify matches	1.9	3.7	4.7	1.7	1.9	2.2
Illnesses of father: Heart disease	1.9	2.6	2.8	1.6	1.7	1.6
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	2.8	-1.5	-1.7	-1.4
Depressed Affect (Nagel 2018)	1.8	3.7	4.2	-1.8	-1.9	-2.0
Breast Cancer	1.8	4.3	4.6	-2.1	-2.0	-2.1
HDL Cholesterol	1.8	3.0	8.9	3.0	0.0	0.0
Depression (self-reported)	1.8	2.1	2.6	1.6	1.6	1.1
Medication: Allopurinol	1.8	2.3	2.7	1.4	1.6	1.6
Vascular/heart problems diagnosed by doctor	1.8	5.0	7.4	-2.1	-1.9	-2.7
Age when periods started (menarche)	1.7	4.0	4.2	-2.0	-2.1	-1.9
Qualifications: CSEs or equivalent	1.7	2.3	2.5	-1.6	-1.6	-1.4
Gout (self-reported)	1.7	2.4	2.8	1.4	1.6	1.7
Whole body fat mass	1.7	7.0	8.8	3.0	2.9	1.9
Age at last live birth	1.7	2.5	4.3	1.3	1.2	2.1
Commuting to job workplace: Cycle	1.7	2.1	3.7	1.2	1.0	1.9
Cardiovascular Disease	1.6	5.3	6.0	2.2	2.2	2.5
Hand grip strength (left)	1.6	4.2	4.8	2.2	2.2	1.8
Average weekly spirits intake	1.6	1.9	3.1	1.1	1.2	1.8
Ever highly irritable/argumentative for 2 days	1.6	1.9	3.2	-1.1	-1.1	-1.8
Systolic blood pressure, automated reading	1.5	4.2	5.8	2.2	2.4	1.5
Time employed in main current job	1.5	1.8	2.5	1.2	1.2	1.6
Alcohol intake versus 10 years previously	1.5	2.2	4.5	-1.0	-1.1	-2.1
Tense / ‘highly strung’	1.5	2.4	4.5	1.1	1.2	2.1
Chronic bronchitis/emphysema (mother)	1.5	1.7	1.9	-1.4	-1.4	-1.2
Leg fat percentage (right)	1.5	5.3	9.8	-1.7	-1.7	-3.1
Medication: Bendroflumethiazide	1.5	2.2	3.2	1.4	1.2	1.8
Neuroticism (2016)	1.4	2.0	3.1	-1.6	-1.8	-0.4
Neuroticism	1.4	3.4	4.2	-2.0	-2.0	-1.4
Impedance of leg (left)	1.4	6.8	8.1	-2.5	-2.5	-2.9
Had major operations	1.4	1.6	2.8	-1.0	-1.1	-1.7
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	2.3	1.3	1.5	1.0
Back pain experienced in last month	1.4	2.1	3.6	-1.1	-1.2	-1.9
Irritable Bowel Disease (IBD)	1.3	3.0	3.2	1.7	1.7	1.8
Impedance of leg (right)	1.3	6.5	7.4	-2.4	-2.5	-2.7
Diabetes (self-reported)	1.3	2.0	2.3	1.5	1.4	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.6	1.9	-1.3	-1.2	-1.4
Wheeze or whistling in the chest in last year	1.3	2.3	4.6	-1.1	-1.1	-2.2
Long-standing illness, disability or infirmity	1.3	2.0	2.8	-1.2	-1.4	-1.7
Medication for cholesterol	1.3	1.9	3.0	-1.2	-1.1	-1.7
Ever had prostate specific antigen (PSA) test	1.3	1.5	1.8	-1.3	-1.3	-1.1
Age started oral contraceptive pill	1.3	1.6	1.7	1.2	1.3	1.3
Crohns Disease (2012)	1.2	1.9	3.0	1.7	1.7	0.0
Systolic Blood Pressure	1.2	6.2	7.5	2.5	2.7	2.2
Pulse wave peak to peak time	1.2	1.4	1.8	-1.1	-1.1	-1.3
Leg fat percentage (left)	1.2	4.2	8.1	-1.5	-1.5	-2.8
Diabetes (mother)	1.1	1.4	1.9	1.4	1.2	1.0
Number of full brothers	1.1	1.4	1.5	-1.2	-1.2	-1.1
Shortness of breath walking on level ground	1.1	1.3	1.5	-1.1	-1.2	-1.2
Miserableness	1.1	1.9	3.1	-1.0	-1.2	-1.8
Illnesses of father: High blood pressure	1.1	1.4	1.4	1.2	1.1	1.2
Rheumatoid Arthritis	1.0	1.4	1.5	1.2	1.1	1.1
Medication: Co-codamol	1.0	1.1	1.3	-0.9	-1.1	-1.2
Diabetes (father)	1.0	1.2	1.4	-1.0	-1.1	-1.2
Maternal smoking around birth	1.0	1.5	2.3	-1.1	-1.0	-1.5
Arm fat mass (right)	1.0	4.0	5.2	2.3	2.3	1.3
High blood pressure (siblings)	1.0	1.5	1.7	1.3	1.3	1.0
Breast cancer (self-reported)	1.0	1.2	1.3	1.1	1.2	1.0
Arm fat mass (left)	1.0	4.0	5.2	2.3	2.2	1.3
Bipolar Disorder or Schizophrenia	0.9	2.2	3.4	1.3	1.2	1.8
Crohns Disease (2017)	0.9	2.0	2.1	1.4	1.4	1.4
Fasting Glucose	0.9	1.1	1.1	-1.1	-1.0	-1.0
Supplements: Zinc	0.9	0.9	1.4	1.0	1.2	0.6
Headache pain in last month	0.9	1.6	1.8	-1.2	-1.2	-1.3
Medication: Amlodipine	0.9	1.2	2.5	0.8	0.7	1.6
Worry too long after embarrassment	0.9	1.6	2.4	-1.5	-1.4	-0.5
Medication: Omeprazole	0.9	1.0	1.3	-1.0	-1.2	-0.9
Diabetes diagnosed by doctor	0.9	1.4	1.8	1.3	1.2	1.1
Pain type(s) experienced in last month: Hip pain	0.9	1.2	2.5	-0.6	-0.8	-1.6
Number of operations (self-reported)	0.9	1.3	1.7	-1.1	-1.0	-1.3
Alzheimer’s Disease (including proxy)	0.8	1.1	2.6	-0.7	-0.5	-1.6
Respiratory disease	0.8	1.9	3.5	-1.0	-1.0	-1.9
Relative age of first facial hair	0.8	1.7	1.8	1.3	1.2	1.4
Hand grip strength (right)	0.8	2.3	2.9	1.6	1.7	1.2
Fluid intelligence score	0.8	1.6	3.2	1.0	0.8	1.8
Heart disease (mother)	0.8	0.9	1.7	0.9	0.6	1.3
Leg pain on walking	0.8	1.1	1.3	1.1	1.1	0.9
Ever taken oral contraceptive pill	0.8	0.8	1.2	-0.9	-0.8	-1.1
Medication: Lisinopril	0.8	1.1	1.5	1.1	0.8	1.2
Schizophrenia (2018)	0.7	1.5	2.6	1.1	0.8	1.6
Vitamin and mineral supplements	0.7	1.0	1.4	-0.8	-0.9	-1.2
Hair/balding pattern: Pattern 2	0.7	0.9	1.6	0.8	0.7	1.2
Father’s age at death	0.7	0.9	2.2	0.6	0.3	1.5
Falls in the last year	0.7	0.9	1.1	1.1	1.1	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	1.3	1.1	1.1	0.8
Hair/balding pattern: Pattern 4	0.7	1.7	2.1	1.5	1.3	1.2
Medication: Paracetamol	0.7	1.1	1.4	-1.1	-1.2	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	1.0	-0.9	-0.8	-1.0
Medication for pain relief, constipation, heartburn	0.7	1.2	1.3	1.1	1.1	1.1
Medication: Blood pressure	0.7	1.2	1.9	0.9	0.9	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.8	0.6	0.6	1.3
Supplements: Vitamin C	0.7	0.9	1.2	0.7	0.9	1.1
Handedness (chirality/laterality): Left-handed	0.7	0.9	1.2	1.1	0.9	0.7
Alcohol drinker status: Previous	0.7	0.8	0.9	-0.9	-0.9	-0.9
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.5	1.0	0.9	1.9
Sensitivity / hurt feelings	0.6	1.0	2.4	0.5	0.5	1.6
Medication for hormone replacement therapy	0.6	0.6	1.1	0.7	1.0	0.5
Current tobacco smoking	0.6	0.9	2.6	-0.3	-0.4	-1.6
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	1.1	1.0	0.7	0.8
High blood pressure (mother)	0.6	0.8	1.8	-0.9	-1.3	0.1
Alcohol usually taken with meals	0.6	0.9	2.3	0.5	0.4	1.5
Pain all over the body in last month	0.6	0.7	1.3	-0.6	-0.6	-1.2
Worrier / anxious feelings	0.6	1.2	2.3	0.7	0.8	1.5
Asthma	0.6	1.3	2.2	-0.9	-0.9	-1.5
Suffer from ‘nerves’	0.6	0.9	1.1	-1.1	-1.0	-0.8
Asthma (self-reported)	0.6	1.1	2.1	-0.8	-0.8	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	1.8	1.1	1.4	1.0
Commuting to job workplace: Public transport	0.6	0.8	0.9	0.9	0.9	0.7
Bipolar Disorder (2018)	0.5	0.7	0.9	0.8	0.8	0.9
Neuroticism (Nagel 2018)	0.5	1.3	1.8	-1.3	-1.3	-0.5
Ulcerative Colitis (UC)	0.5	0.9	1.1	0.9	0.9	1.0
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.7	0.8	0.5	1.6
Frequency of depressed mood in last 2 weeks	0.5	0.8	1.0	-0.9	-1.0	-0.6
Ever had hysterectomy (womb removed)	0.5	0.6	0.8	-0.9	-0.9	-0.5
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	0.9	0.9	1.0	0.7
Lung cancer (father)	0.5	0.6	1.0	-0.8	-1.0	-0.4
Breastfed as a baby	0.5	0.6	1.7	0.2	0.2	1.3
Birth weight	0.5	1.1	1.5	-1.2	-1.2	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.5	-0.4	-0.3	-1.2
Mood swings	0.5	0.9	1.0	-0.9	-1.0	-0.9
Osteoporosis (self-reported)	0.5	0.7	1.0	-0.7	-0.7	-1.0
Medication: Gliclazide	0.5	0.6	0.7	-0.8	-0.7	-0.8
Financial situation satisfaction	0.5	0.6	0.9	0.9	0.9	-0.1
Diastolic blood pressure, automated reading	0.5	1.6	1.9	1.4	1.3	1.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.0	-0.7	-0.7	-1.0
Worry (Nagel 2018)	0.4	0.8	2.1	0.4	0.4	1.5
Prostate Cancer	0.4	0.6	1.0	0.7	0.6	1.0
Body Mass Index (BMI) (2010)	0.4	0.6	1.7	-1.3	0.0	0.0
Heel T-Score	0.4	2.8	4.2	-1.6	-1.3	-2.0
Chronotype (morning person)	0.4	1.0	1.2	-1.0	-1.1	-0.9
Trunk fat percentage	0.4	1.6	2.5	1.5	1.6	0.4
Taking other prescription medications	0.4	0.7	1.0	0.9	1.0	0.3
Mouth/teeth dental problems	0.4	0.6	0.6	0.7	0.8	0.8
Neuroticism score	0.4	0.9	1.2	-1.1	-1.1	-0.5
Medication: Lansoprazole	0.4	0.5	0.7	0.7	0.8	0.6
Illnesses of mother	0.4	0.5	1.1	0.7	1.1	0.1
Blood clot in the leg (DVT)	0.4	0.5	0.6	-0.7	-0.7	-0.8
Medication: Aspirin	0.4	0.6	0.6	-0.7	-0.7	-0.8
Guilty feelings	0.4	0.6	0.8	-0.9	-0.9	-0.5
Medication: Atorvastatin	0.4	0.5	0.7	0.8	0.7	0.5
Depression (Nagel 2018)	0.3	0.4	0.5	-0.7	-0.6	-0.6
Alzheimer’s Disease (in mother)	0.3	0.4	0.7	-0.6	-0.4	-0.8
LDL Cholesterol	0.3	0.4	1.3	-1.2	0.0	0.0
Blood White Count	0.3	2.1	4.1	-1.1	-1.0	-2.0
Allergy or Eczema	0.3	0.9	1.7	-0.7	-0.7	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	-0.4	-0.4	-0.9
Multivitamins +/- minerals	0.3	0.4	0.7	0.5	0.5	0.8
Had other major operations	0.3	0.3	0.5	-0.5	-0.5	-0.7
Financial difficulties in last 2 years	0.3	0.4	0.5	-0.5	-0.7	-0.6
Medication: Ramipril	0.3	0.4	1.0	0.2	0.2	1.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.5	0.6	0.6	0.7
Glaucoma (self-reported)	0.3	0.4	0.4	0.6	0.6	0.6
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.7	-0.4	-0.4	-0.8
Exposure to tobacco smoke outside home	0.3	0.5	1.1	-0.4	-0.4	-1.0
Overall health rating	0.3	0.7	1.2	-0.7	-0.6	-1.1
Smoking status: Current	0.3	0.5	1.5	0.1	0.1	-1.2
Wears glasses or contact lenses	0.3	0.4	1.0	0.2	0.3	1.0
Eye problems/disorders: Glaucoma	0.3	0.3	0.4	0.5	0.6	0.6
Leg fat mass (left)	0.3	1.2	1.8	1.4	1.3	0.2
Ovarian Cancer	0.2	0.2	0.3	-0.5	-0.3	-0.5
Mean Putamen Volume	0.2	0.3	0.4	-0.4	-0.6	-0.6
Waist Hip Ratio (WHR)	0.2	0.8	1.6	-0.6	-0.7	-1.3
Lung FEV1/FVC ratio	0.2	1.0	1.4	-1.2	-1.2	-0.6
Lung FVC	0.2	0.9	2.4	-0.3	-0.4	-1.5
Tanning	0.2	2.9	3.3	1.8	1.8	1.5
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.4	0.6	0.5	0.4
Average weekly fortified wine intake	0.2	0.3	0.3	-0.6	-0.6	-0.3
Relative age voice broke	0.2	0.3	0.3	0.5	0.5	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.5	-0.6	-0.6	-0.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.5	0.5	0.3	0.7
Supplements: Glucosamine	0.2	0.3	0.7	-0.3	-0.3	-0.8
Medication: Atenolol	0.2	0.3	0.4	0.5	0.5	0.6
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	-0.1	-0.0	-0.7
Nervous feelings	0.2	0.3	0.8	0.2	0.2	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.0	-0.4	-0.4	-1.0
Arm fat percentage (right)	0.2	0.7	2.0	-0.2	-0.1	-1.4
Noisy workplace	0.2	0.2	0.6	0.2	0.2	-0.8
Prospective memory result	0.2	0.3	0.5	-0.6	-0.7	0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.5	0.6	0.7	0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	-0.5	-0.3	-0.7
Medication: Ibuprofen	0.2	0.3	0.3	0.5	0.4	0.6
Medication: Seretide 50 evohaler	0.2	0.2	0.4	0.6	0.5	0.2
Leg fat mass (right)	0.2	0.9	1.5	1.2	1.1	0.1
Number of full sisters	0.2	0.2	0.6	-0.2	-0.2	-0.8
Average weekly red wine intake	0.2	0.3	0.6	-0.6	-0.8	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	-0.4	-0.1	-0.7
Medication: Aspirin	0.2	0.2	0.3	-0.4	-0.6	-0.4
Number of self-reported non-cancer illnesses	0.2	0.4	0.4	0.6	0.6	0.6
Average weekly beer plus cider intake	0.2	0.3	0.3	0.5	0.5	0.5
Irritability	0.2	0.4	0.6	0.8	0.8	0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.1	0.2	0.4	-0.4
Triglycerides	0.1	0.1	0.4	-0.6	0.0	0.0
Ulcerative Colitis	0.1	0.2	0.3	0.5	0.5	0.2
BMI	0.1	0.8	2.0	-0.4	-0.3	-1.4
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.3	-0.3	-0.4	-0.6
Number of treatments/medications taken	0.1	0.2	0.3	0.5	0.5	-0.0
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.1	0.4	0.3	0.2
Angina	0.1	0.1	0.3	-0.1	-0.2	0.5
Pack years adult smoking proportion	0.1	0.1	0.2	0.2	-0.0	-0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	0.2	0.2	0.5
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.1	-0.2	-0.5
Medication: Levothyroxine sodium	0.1	0.2	0.3	0.4	0.5	0.1
Body mass index (BMI)	0.1	0.3	1.0	0.1	0.2	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	0.3	0.2	0.7
Had menopause	0.1	0.1	0.3	0.1	0.1	0.6
Hair/balding pattern: Pattern 3	0.1	0.1	0.1	0.2	0.4	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.5	0.1	0.1	0.7
Mouth/teeth dental problems: Dentures	0.1	0.2	0.2	-0.4	-0.3	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.4	0.1	0.1	0.6
Medication: Cholesterol lowering	0.1	0.2	0.3	-0.5	-0.4	-0.3
Impedance of arm (left)	0.1	0.3	0.5	0.4	0.5	0.7
Length of working week for main job	0.1	0.1	0.1	0.2	0.3	0.2
Body fat percentage	0.1	0.4	1.1	0.2	0.2	-1.0
Number of children fathered	0.1	0.1	0.1	0.3	0.1	-0.4
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.4	-0.4	0.1
Emphysema/chronic bronchitis	0.1	0.1	0.3	-0.0	0.1	-0.6
Angina (self-reported)	0.1	0.2	0.5	0.0	-0.1	0.7
Chest pain or discomfort	0.1	0.2	0.6	-0.0	-0.1	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.4	0.2	0.1	-0.6
Illnesses of siblings: Diabetes	0.1	0.1	0.3	-0.1	-0.1	-0.5
Arm fat percentage (left)	0.1	0.5	1.6	-0.1	-0.0	-1.2
Ever had bowel cancer screening	0.1	0.2	0.2	0.5	0.5	-0.2
Qualifications: nursing, teaching	0.1	0.2	0.3	-0.3	-0.3	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	0.3	0.4	-0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	-0.3	-0.4	-0.4
Medication: Paracetamol	0.1	0.1	0.2	-0.3	-0.5	-0.3
Supplements: Calcium	0.1	0.1	0.1	-0.3	-0.4	-0.1
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	-0.2	-0.3	-0.3
Heart disease (siblings)	0.1	0.2	0.3	0.5	0.5	0.0
Pack years of smoking	0.1	0.2	0.4	0.6	0.5	0.1
Impedance of whole body	0.1	0.6	0.7	-0.8	-0.8	-0.8
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Lupus	0.0	0.0	0.1	0.1	0.0	0.3
Primary Biliary Cirrhosis	0.0	0.1	0.2	0.1	0.0	-0.4
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Blood Red Count	0.0	0.2	0.3	-0.3	-0.6	0.5
Hypothyroidism (self reported)	0.0	0.0	0.1	-0.2	-0.3	0.1
Hair Pigment	0.0	0.5	1.0	0.3	0.5	1.0
Medication: Metformin	0.0	0.0	0.0	-0.1	-0.2	0.0
Serious illness, injury or assault to yourself	0.0	0.0	0.1	0.0	0.1	-0.3
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.1	0.2	0.3	-0.1
Allergy	0.0	0.1	0.3	0.0	0.0	0.6
Medication: Simvastatin	0.0	0.0	0.1	-0.0	0.1	0.2
Impedance of arm (right)	0.0	0.2	0.2	0.3	0.4	0.4
Birth weight of first child	0.0	0.0	0.0	-0.0	-0.1	0.1
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.0	0.1	0.0	0.0
Migraine (self-reported)	0.0	0.0	0.1	0.1	0.0	0.3
Family relationship satisfaction	0.0	0.0	0.0	-0.1	-0.1	0.2
Eye problems/disorders: Cataract	0.0	0.0	0.1	0.2	0.1	0.3
Mineral and other dietary supplements	0.0	0.0	0.0	-0.1	-0.1	-0.1
Mother’s age at death	0.0	0.0	0.1	0.0	-0.2	-0.3
High cholesterol (Self-reported)	0.0	0.1	0.2	0.1	0.3	0.4
Alcohol drinker status: Never	0.0	0.0	0.0	-0.0	-0.1	0.1
Risk taking	0.0	0.0	0.0	0.0	0.1	0.0
Fractured/broken bones in last 5 years	0.0	0.1	0.1	-0.1	-0.3	-0.3
Myopia	0.0	0.0	0.1	0.1	0.2	0.3
Cholesterol lowering medication	0.0	0.0	0.1	-0.0	-0.3	-0.0

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