[Hub]/) : Traits : Forced vital capacity (FVC) :

chr2:134,794,256-137,435,625

Best TWAS P=3.73e-12 · Best GWAS P=2.37e-11 conditioned to 0.000146

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CCNT2 0.12 0.11 lasso 2 0.10 9.8e-13 5.4 5.4 6.7e-08 0.34 0.06 0.94 FALSE
2 CommonMind Brain Pre-frontal Cortex LOC100129961 0.17 0.14 enet 9 0.14 2.6e-17 -5.1 -5.5 2.9e-08 -0.36 0.22 0.78 FALSE
3 GTEx Artery Aorta CCNT2 0.12 0.12 lasso 3 0.11 1.9e-06 5.4 5.4 5.6e-08 0.34 0.06 0.92 FALSE
4 GTEx Esophagus Mucosa DARS 0.12 0.05 lasso 4 0.04 9.0e-04 5.7 5.9 2.9e-09 0.42 0.16 0.66 FALSE
5 GTEx Esophagus Muscularis DARS 0.12 0.11 lasso 3 0.09 3.5e-06 5.7 5.9 3.9e-09 0.40 0.22 0.78 FALSE
6 GTEx Lung DARS 0.07 0.05 lasso 4 0.05 5.8e-05 5.7 5.8 4.8e-09 0.40 0.22 0.76 FALSE
7 GTEx Nerve Tibial DARS 0.13 0.06 lasso 5 0.05 3.2e-04 6.0 6.0 2.4e-09 0.41 0.19 0.72 FALSE
8 GTEx Skin Not Sun Exposed Suprapubic DARS 0.15 0.11 enet 4 0.10 3.0e-06 5.7 6.0 1.8e-09 0.41 0.20 0.78 FALSE
9 GTEx Skin Sun Exposed Lower leg DARS 0.10 0.12 lasso 1 0.11 1.7e-09 5.7 5.7 1.5e-08 0.39 0.41 0.59 FALSE
10 GTEx Testis AC016725.4 0.18 0.09 lasso 6 0.09 6.3e-05 -5.2 5.3 1.1e-07 0.37 0.03 0.96 FALSE
11 GTEx Thyroid DARS 0.20 0.13 lasso 3 0.15 1.3e-11 5.7 6.1 1.0e-09 0.42 0.27 0.73 FALSE
12 NTR Blood CCNT2 0.01 0.00 blup 370 0.00 6.7e-02 5.1 5.2 1.5e-07 0.35 0.11 0.59 FALSE
13 NTR Blood MCM6 0.02 0.02 lasso 2 0.03 1.2e-08 5.4 6.3 3.9e-10 0.47 0.26 0.74 FALSE
14 ROSMAP Brain Pre-frontal Cortex CCNT2 0.06 0.03 enet 27 0.05 1.6e-06 5.5 6.0 2.2e-09 0.41 0.03 0.97 FALSE
15 YFS Blood DARS 0.17 0.19 enet 36 0.19 8.2e-60 6.0 7.0 3.7e-12 0.48 0.18 0.82 TRUE
16 YFS Blood MCM6 0.18 0.15 enet 20 0.20 8.5e-64 5.8 5.7 1.2e-08 0.55 0.45 0.55 FALSE
17 The Cancer Genome Atlas Breast Invasive Carcinoma LCT 0.02 0.02 enet 3 0.03 7.6e-07 5.8 -6.3 2.2e-10 -0.47 0.02 0.98 FALSE
18 The Cancer Genome Atlas Glioblastoma Multiforme LCT 0.16 0.08 blup 36 0.10 5.3e-04 5.4 -5.2 2.1e-07 -0.45 0.03 0.36 FALSE
19 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma DARS 0.04 0.05 lasso 2 0.05 3.5e-06 5.4 5.6 2.6e-08 0.39 0.02 0.98 FALSE
20 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ACMSD 0.04 0.01 blup 46 0.02 2.2e-03 5.0 5.6 2.0e-08 0.37 0.04 0.71 FALSE
21 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DARS 0.10 0.08 enet 14 0.11 5.5e-12 6.0 5.6 2.0e-08 0.39 0.02 0.98 FALSE
22 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma LCT 0.04 0.02 blup 36 0.02 1.9e-03 5.4 -6.1 8.6e-10 -0.50 0.05 0.83 FALSE
23 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma DARS 0.09 0.07 blup 40 0.06 1.6e-04 6.1 5.5 2.9e-08 0.27 0.02 0.97 FALSE
24 The Cancer Genome Atlas Lung Squamous Cell Carcinoma DARS 0.02 0.02 lasso 2 0.02 3.9e-03 6.0 6.1 1.4e-09 0.39 0.01 0.94 FALSE
25 The Cancer Genome Atlas Pancreatic Adenocarcinoma DARS 0.08 0.10 lasso 4 0.09 8.8e-05 6.0 6.0 1.7e-09 0.41 0.02 0.94 FALSE
26 The Cancer Genome Atlas Prostate Adenocarcinoma DARS 0.04 0.02 blup 40 0.01 2.1e-02 5.7 6.7 1.8e-11 0.44 0.02 0.93 FALSE
27 The Cancer Genome Atlas Soft Tissue Sarcoma DARS 0.04 0.04 blup 40 0.04 1.6e-03 6.0 6.3 3.9e-10 0.45 0.02 0.93 FALSE
28 The Cancer Genome Atlas Thyroid Carcinoma DARS 0.22 0.15 enet 13 0.19 4.1e-18 5.6 5.9 4.3e-09 0.33 0.03 0.97 FALSE